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List of epidemics and pandemics

February 15, 2024

This is a list of the largest known epidemics and pandemics caused by an infectious disease. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included. An epidemic is the rapid spread of disease to a large number of people in a given population within a short period of time; in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.[1] Due to the long time spans, the first plague pandemic (6th century – 8th century) and the second plague pandemic (14th century – early 19th century) are shown by individual outbreaks, such as the Plague of Justinian (first pandemic) and the Black Death (second pandemic).

Pandemics timeline death tolls

Infectious diseases with high prevalence are listed separately (sometimes in addition to their epidemics), such as malaria, which may have killed 50–60 billion people throughout history, or about half of all humans that have ever lived.[2]

Major epidemics and pandemics

By death toll

Ongoing epidemics and pandemics are in boldface. For a given epidemic or pandemic, the average of its estimated death toll range is used for ranking. If the death toll averages of two or more epidemics or pandemics are equal, then the smaller the range, the higher the rank. For the historical records of major changes in the world population, see world population.[3][4]

Epidemics and pandemics with at least 1 million deaths
Rank Epidemics/pandemics Disease Death toll Global population lost Regional population lost Years Location
1 Black Death Bubonic plague 25-50 million 17–54%[a] 30–60% of European population[5] 1346–1353 Europe, Asia, and North Africa
2 Spanish flu Influenza A/H1N1 17–100 million 1–5.4%[6][7] – 1918–1920 Worldwide
3 Plague of Justinian Bubonic plague 15–100 million 7–56%[a] 25–60% of European population[8] 541–549 North Africa, Europe, and Western Asia
4 HIV/AIDS epidemic HIV/AIDS 43 million (as of 2024) [b] – 1981–present[9] Worldwide
5 COVID-19 pandemic COVID-19 7–21 million[10][11] (as of January 2024) 0.1–0.46%[3][better source needed] – 2019–present[12] Worldwide
6 Third plague pandemic Bubonic plague 12–15 million [b] – 1855–1960 Worldwide
7 Cocoliztli epidemic of 1545–1548 Cocoliztli, caused by an unidentified pathogen 5–15 million 1–3%[a] 27–80% of Mexican population[13] 1545–1548 Mexico
8 Antonine Plague Smallpox or measles 5–10 million 3–6%[4] 25–33% of Roman population[14] 165–180 (possibly up to 190) Roman Empire
9 1520 Mexico smallpox epidemic Smallpox 5–8 million 1–2%[a] 23–37% of Mexican population[13] 1519–1520 Mexico
10 1918–1922 Russia typhus epidemic Typhus 2–3 million 0.1–0.16%[7][c] 1–1.6% of Russian population[15] 1918–1922 Russia
11 1957–1958 influenza pandemic Influenza A/H2N2 1–4 million 0.03–0.1%[3] – 1957–1958 Worldwide
12 Hong Kong flu Influenza A/H3N2 1–4 million 0.03–0.1%[3] – 1968–1969 Worldwide
13 Cocoliztli epidemic of 1576 Cocoliztli 2–2.5 million 0.4–0.5%[4] 50% of Mexican population[13] 1576–1580 Mexico
14 735–737 Japanese smallpox epidemic Smallpox 2 million 1%[4] 33% of Japanese population[16] 735–737 Japan
15 1772–1773 Persian Plague Bubonic plague 2 million 0.2–0.3%[4] [d] 1772–1773 Persia
16 Naples Plague Bubonic plague 1.25 million 0.2%[4] [d] 1656–1658 Southern Italy
17 1846–1860 cholera pandemic Cholera 1 million+ 0.08%[4] – 1846–1860 Worldwide
18 1629–1631 Italian plague Bubonic plague 1 million 0.2%[4] [d] 1629–1631 Italy
19 1889–1890 flu pandemic Influenza (disputed)[17][18] 1 million 0.07%[4] – 1889−1890 Worldwide

Depopulation of the Americas

Main article: Population history of Indigenous peoples of the Americas § Depopulation by Old World diseases

Not included in the above table are many waves of deadly diseases brought by Europeans to the Americas and Caribbean. Western Hemisphere populations were ravaged mostly by smallpox, but also typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever, and pertussis. The lack of written records in many places and the destruction of many native societies by disease, war, and colonization make estimates uncertain. Deaths probably numbered in the tens or perhaps over a hundred million, with perhaps 90% of the population dead in the worst-hit areas. Lack of scientific knowledge about microorganisms and lack of surviving medical records for many areas makes attribution of specific numbers to specific diseases uncertain.

Infectious diseases with high prevalence

Further information: List of causes of death by rate

There have been various major infectious diseases with high prevalence worldwide, but they are currently not listed in the above table as epidemics/pandemics due to the lack of definite data, such as time span and death toll.

 
An Ethiopian child with malaria, a disease with an annual death rate of 619,000 as of 2021.[19]
  • Malaria has had multiple documented temporary epidemics in otherwise non-affected or low-prevalence areas, but the vast majority of its deaths are due to its constant prevalence in affected areas.[2]
  • Tuberculosis (TB) became epidemic in Europe in the 18th and 19th century, showing a seasonal pattern, and is still taking place globally.[20][21][22] The morbidity and mortality of TB and HIV/AIDS have been closely linked, known as "TB/HIV syndemic".[22][23] According to the World Health Organization, approximately 10 million new TB infections occur every year, and 1.5 million people die from it each year – making it the world's top infectious killer (before COVID-19 pandemic).[22] However, there is a lack of sources which describe major TB epidemics with definite time spans and death tolls.
  • Hepatitis B: According to the World Health Organization, as of 2019 there are about 296 million people living with chronic hepatitis B, with 1.5 million new infections each year. In 2019, hepatitis B caused about 820,000 deaths, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer).[24] In many places of Asia and Africa, hepatitis B has become endemic.[25] In addition, a person is sometimes infected with both hepatitis B virus (HBV) and HIV, and this population (about 2.7 million) accounts for about 1% of the total HBV infections.[24]
  • Hepatitis C: According to the World Health Organization, there are approximately 58 million people with chronic hepatitis C, with about 1.5 million new infections occurring per year. In 2019, approximately 290,000 people died from the disease, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer).[26] There have been many hepatitis C virus (HCV) epidemics in history.[27][28][29]

Chronology

Events in boldface are ongoing.

Chronological table of epidemic and pandemic events in human history
Event Years Location Disease Death toll (estimate) Ref.
1350 BC plague of Megiddo 1350 BC Megiddo, land of Canaan Amarna letters EA 244, Biridiya, mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust" Unknown [30]
Plague of Athens 430–426 BC Greece, Libya, Egypt, Ethiopia Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever 75,000–100,000 [31][32][33][34]
412 BC epidemic 412 BC Greece (Northern Greece, Roman Republic) Unknown, possibly influenza 473,000 (10% of the Roman Population) [35]
Antonine Plague 165–180 (possibly up to 190) Roman Empire Unknown, possibly smallpox 5–10 million [36][37]
Jian'an Plague 217 Han Dynasty Unknown, possibly typhoid fever or viral hemorrhagic fever 2 Million [38][39]
Plague of Cyprian 249–262 Europe Unknown, possibly smallpox 310,000 [40][41]
Plague of Justinian (beginning of first plague pandemic) 541–549 Europe and West Asia Bubonic plague 15–100 million [8][42][43]
580 Dysentery Epidemic in Gaul 580 Gaul Dysentery or possibly smallpox 450,000 (10% of the Gaul population) [44]
Roman Plague of 590 (part of first plague pandemic) 590 Rome, Byzantine Empire Bubonic plague Unknown [45]
Plague of Sheroe (part of first plague pandemic) 627–628 Bilad al-Sham Bubonic plague 25,000+
Plague of Amwas (part of first plague pandemic) 638–639 Byzantine Empire, West Asia, Africa Bubonic plague 25,000+ [46]
Plague of 664 (part of first plague pandemic) 664–689 British Isles Bubonic plague Unknown [47]
Plague of 698–701 (part of first plague pandemic) 698–701 Byzantine Empire, West Asia, Syria, Mesopotamia Bubonic plague Unknown [48]
735–737 Japanese smallpox epidemic 735–737 Japan Smallpox 2 million (approx. 1⁄3 of Japanese population) [16][49]
Plague of 746–747 (part of first plague pandemic) 746–747 Byzantine Empire, West Asia, Africa Bubonic plague Unknown [46]
Black Death (start of the second plague pandemic) 1346–1353 Eurasia and North Africa Bubonic plague 75–200 million (30–60% of European population and 33% percent of the Middle Eastern population) [50]
Sweating sickness (multiple outbreaks) 1485–1551 Britain (England) and later continental Europe Unknown, possibly an unknown species of hantavirus 10,000+ [51]
1489 Spain typhus epidemic 1489 Spain Typhus 17,000 [52]
1510 influenza pandemic 1510 Asia, North Africa, Europe Influenza Unknown, around 1% of those infected [53]
1520 Mexico smallpox epidemic 1519–1520 Mexico Smallpox 5–8 million (40% of population) [13]
Cocoliztli epidemic of 1545–1548 1545–1548 Mexico Possibly Salmonella enterica 5–15 million (80% of population) [54][55][56][57]
1557 influenza pandemic 1557–1559 Asia, Africa, Europe, and Americas Influenza 2.5–5 Million (10% of the infected)
1561 Chile smallpox epidemic 1561–1562 Chile Smallpox 120,000–150,000 (20–25% of native population) [58]
1563 London plague (part of the second plague pandemic) 1563–1564 London, England Bubonic plague 20,100+ [59]
Cocoliztli epidemic of 1576 1576–1580 Mexico Possibly Salmonella enterica 2–2.5 million (50% of population) [54][55][56][57]
1582 Tenerife plague epidemic (part of the second plague pandemic) 1582–1583 Tenerife, Spain Bubonic plague 5,000–9,000 [60]
1592–1596 Seneca nation measles epidemic 1592–1596 Seneca nation, North America Measles Unknown [61]
1592–1593 Malta plague epidemic (part of the second plague pandemic) 1592–1593 Malta Bubonic plague 3,000 [62]
1592–1593 London plague (part of the second plague pandemic) 1592–1593 London, England Bubonic plague 19,900+ [63]
1596–1602 Spain plague epidemic (part of the second plague pandemic) 1596–1602 Spain Bubonic plague 600,000–700,000 [64]
1600–1650 South America malaria epidemic 1600–1650 South America Malaria Unknown [citation needed]
1603 London plague (part of the second plague pandemic) 1603 London, England Bubonic plague 40,000 [65][66][67]
1616 New England infections epidemic 1616–1620 Southern New England, British North America, especially the Wampanoag people Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D 1,143,000–3,429,000 (estimated 30–90% of population) [68][69]
1629–1631 Italian plague (part of the second plague pandemic) 1629–1631 Italy Bubonic plague 1 million [70]
1632–1635 Augsburg plague epidemic (part of the second plague pandemic) 1632–1635 Augsburg, Germany Bubonic plague 13,712 [71]
Massachusetts smallpox epidemic 1633–1634 Massachusetts Bay Colony, Thirteen Colonies Smallpox 1,000 [72]
1634–1640 Wyandot people epidemic 1634–1640 Wyandot people, North America Smallpox and Influenza 15,000–25,000 [73]
1637 London plague epidemic (part of the second plague pandemic) 1636–1637 London and Westminster, England Bubonic plague 10,400 [74]
Great Plague in the late Ming dynasty (part of the second plague pandemic) 1633–1644 China Bubonic plague 200,000+ [75][76]
Great Plague of Seville (part of the second plague pandemic) 1647–1652 Spain Bubonic plague 500,000 [77]
1648 Central America yellow fever epidemic 1648 Central America Yellow fever Unknown [78]
Naples Plague (part of the second plague pandemic) 1656–1658 Italy Bubonic plague 1,250,000 [79]
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic) 1663–1664 Amsterdam, Netherlands Bubonic plague 24,148 [80]
Great Plague of London (part of the second plague pandemic) 1665–1666 England Bubonic plague 100,000 [81][82]
1668 France plague (part of the second plague pandemic) 1668 France Bubonic plague 40,000 [83]
1675–1676 Malta plague epidemic (part of the second plague pandemic) 1675–1676 Malta Bubonic plague 11,300 [84]
1676–1685 Spain plague (part of the second plague pandemic) 1676–1685 Spain Bubonic plague Unknown [85]
1677–1678 Boston smallpox epidemic 1677–1678 Massachusetts Bay Colony, British North America Smallpox 750–1,000 [86]
Great Plague of Vienna (part of the second plague pandemic) 1679 Vienna, Austria Bubonic plague 76,000 [87]
1681 Prague plague epidemic (part of the second plague pandemic) 1681 Prague, Czech Kingdom Bubonic plague 83,000 [88]
1687 South Africa influenza outbreak 1687 South Africa Unknown, possibly influenza Unknown [89]
1693 Boston yellow fever epidemic 1693 Boston, Massachusetts Bay Colony, British North America Yellow fever 3,100+ [90]
1699 Charleston and Philadelphia yellow fever epidemic 1699 Charleston and Philadelphia, British North America Yellow fever 520 (300 in Charleston, 220 in Philadelphia) [91]
1702 New York City yellow fever epidemic 1702 New York City, British North America Yellow fever 500 [92]
1702–1703 St. Lawrence Valley smallpox epidemic 1702–1703 New France, Canada Smallpox 1,300 [93]
1707–1708 Iceland smallpox epidemic 1707–1709 Iceland Smallpox 18,000+ (36% of population) [94]
Great Northern War plague outbreak (part of the second plague pandemic) 1710–1712 Denmark, Sweden, Lithuania Bubonic plague 164,000 [95][96]
1713–1715 North America measles epidemic 1713–1715 Thirteen Colonies and New France, Canada Measles Unknown [97][98]
Great Plague of Marseille (part of the second plague pandemic) 1720–1722 France Bubonic plague 100,000+ [99]
1721 Boston smallpox outbreak 1721–1722 Massachusetts Bay Colony Smallpox 844 [100]
1730 Cádiz yellow fever epidemic 1730 Cádiz, Spain Yellow fever 2,200 [101]
1732–1733 Thirteen Colonies influenza epidemic 1732–1733 Thirteen Colonies Influenza Unknown [102]
1733 New France smallpox epidemic 1733 New France, Canada Smallpox Unknown [103]
1735–1741 diphtheria epidemic 1735–1741 New England, Province of New York, Province of New Jersey, British North America Diphtheria 20,000 [104]
Great Plague of 1738 (part of the second plague pandemic) 1738 Balkans Bubonic plague 50,000 [105]
1738–1739 North Carolina smallpox epidemic 1738–1739 Province of Carolina, Thirteen Colonies Smallpox 7,700–11,700 [106]
1741 Cartagena yellow fever epidemic 1741 Cartagena, Colombia Yellow fever 20,000 [107]
1743 Sicily plague epidemic (part of the second plague pandemic) 1743 Messina, Sicily, Italy Bubonic plague 40,000–50,000 [108][109]
1759 North America measles outbreak 1759 North America Measles Unknown [110]
1760 Charleston smallpox epidemic 1760 Charleston, British North America Smallpox 730–940 [111][112]
1762 Havana yellow fever epidemic 1762 Havana, Cuba Yellow fever 8,000 [107]
1763 Pittsburgh area smallpox outbreak 1763 North America, present-day Pittsburgh area Smallpox Unknown [113]
1770–1772 Russian plague (part of the second plague pandemic) 1770–1772 Russia Bubonic plague 50,000 [114]
1772 North America measles epidemic 1772 North America Measles 1,080 [115]
1772–1773 Persian Plague (part of the second plague pandemic) 1772–1773 Persia Bubonic plague 2 million [116]
1775–1776 England influenza outbreak 1775–1776 England Influenza Unknown [117]
1775–1782 North American smallpox epidemic 1775–1782 Native populations in what is now the Pacific Northwest of the United States Smallpox 11,000+ [118][119]
1778 Spain dengue fever outbreak 1778 Spain Dengue fever Unknown [120]
1782 Influenza pandemic 1782 Worldwide Influenza Unknown
1788 Pueblo Indians smallpox epidemic 1788 Pueblo Indians in northern New Spain (what is now the Southwestern United States) Smallpox Unknown [121]
1789–1790 New South Wales smallpox epidemic 1789–1790 New South Wales, Australia Smallpox 125,251–175,351 (50–70% of native population) [122][123]
1793 Philadelphia yellow fever epidemic 1793 Philadelphia, United States Yellow fever 5,000+ [124]
1800–1803 Spain yellow fever epidemic 1800–1803 Spain Yellow fever 60,000+ [125]
1801 Ottoman Empire and Egypt bubonic plague epidemic 1801 Ottoman Empire, Egypt Bubonic plague Unknown [126]
1802–1803 Saint-Domingue yellow fever epidemic 1802–1803 Saint-Domingue Yellow fever 29,000–55,000 [127]
1812 Russia typhus epidemic 1812 Russia Typhus 300,000 [52]
1812–1819 Ottoman plague epidemic (part of the second plague pandemic) 1812–1819 Ottoman Empire Bubonic plague 300,000+ [128]
1813–1814 Malta plague epidemic (part of the second plague pandemic) 1813–1814 Malta Bubonic plague 4,500 [129]
Caragea's plague (part of the second plague pandemic) 1813 Romania Bubonic plague 60,000 [130]
1817–1819 Ireland typhus epidemic 1817–1819 Ireland Typhus 65,000 [131]
First cholera pandemic 1817–1824 Asia, Europe Cholera 100,000+ [132]
1820 Savannah yellow fever epidemic 1820 Savannah, Georgia, United States Yellow fever 700 [133]
1821 Barcelona yellow fever epidemic 1821 Barcelona, Spain Yellow fever 5,000–20,000 [134][135]
Second cholera pandemic 1826–1837 Asia, Europe, North America Cholera 100,000+ [136]
1828–1829 New South Wales smallpox epidemic 1828–1829 New South Wales, Australia Smallpox 19,000 [137][138]
Groningen epidemic 1829 Netherlands Malaria 2,800 [139]
1829–1833 Pacific Northwest malaria epidemic 1829–1833 Pacific Northwest, United States Malaria, possibly other diseases too 150,000 [140][141]
1829–1835 Iran plague outbreak 1829–1835 Iran Bubonic plague Unknown [142]
1834–1836 Egypt plague epidemic 1834–1836 Egypt Bubonic plague Unknown [143]
1837 Great Plains smallpox epidemic 1837–1838 Great Plains, United States and Canada Smallpox 17,000+ [144]
1841 Southern United States yellow fever epidemic 1841 Southern United States (especially Louisiana and Florida) Yellow fever 3,498 [145]
1847 North American typhus epidemic 1847–1848 Canada Typhus 20,000+ [146]
1847 Southern United States yellow fever epidemic 1847 Southern United States (especially New Orleans) Yellow fever 3,400 [147]
1847–1848 influenza epidemic 1847–1848 Worldwide Influenza Unknown [148]
1848–1849 Hawaii epidemic of infections 1848–1849 Hawaiian Kingdom Measles, whooping cough, dysentery and influenza 10,000 [149]
1853 New Orleans yellow fever epidemic 1853 New Orleans, United States Yellow fever 7,970 [134]
Third cholera pandemic 1846–1860 Worldwide Cholera 1 million+ [150]
1853 Ottoman Empire plague epidemic 1853 Ottoman Empire Bubonic plague Unknown [151]
1853 Copenhagen cholera outbreak 1853 Copenhagen, Denmark Cholera 4,737 [152]
1854 Broad Street cholera outbreak 1854 London, England Cholera 616 [153]
1855 Norfolk yellow fever epidemic 1855 Norfolk and Portsmouth, England Yellow fever 3,000 (2,000 in Norfolk, 1,000 in Portsmouth) [154]
Third plague pandemic 1855–1960 Worldwide Bubonic plague 12–15 million (India and China) [155][156]
1855–1857 Montevideo yellow fever epidemic 1855–1857 Montevideo, Uruguay Yellow fever 3,400 (first wave; 900, second wave; 2,500) [157]
1857 Lisbon yellow fever epidemic 1857 Lisbon, Portugal Yellow fever 6,000 [134]
1857 Victoria smallpox epidemic 1857 Victoria, Australia Smallpox Unknown [158]
1857–1859 Europe and the Americas influenza epidemic 1857–1859 Europe, North America, South America Influenza Unknown [159]
1862 Pacific Northwest smallpox epidemic 1862–1863 Pacific Northwest, Canada and United States Smallpox 20,000+ [160][161][162]
1861–1865 United States typhoid fever epidemic 1861–1865 United States Typhoid fever 80,000 [163]
Fourth cholera pandemic 1863–1875 Middle East Cholera 600,000 [164]
1867 Sydney measles epidemic 1867 Sydney, Australia Measles 748 [165]
1871 Buenos Aires yellow fever epidemic 1871 Buenos Aires, Argentina Yellow fever 13,500–26,200 [166]
1870–1875 Europe smallpox epidemic 1870–1875 Europe Smallpox 500,000 [167][168]
1875 Fiji measles outbreak 1875 Fiji Measles 40,000 [169]
1875–1876 Australia scarlet fever epidemic 1875–1876 Australia Scarlet fever 8,000 [165]
1876 Ottoman Empire plague epidemic 1876 Ottoman Empire Bubonic plague 20,000 [170]
1878 New Orleans yellow fever epidemic 1878 New Orleans, United States Yellow fever 4,046 [127]
1878 Mississippi Valley yellow fever epidemic 1878 Mississippi Valley, United States Yellow fever 13,000 [127]
Fifth cholera pandemic 1881–1896 Asia, Africa, Europe, South America Cholera 298,600 [171]
1885 Montreal smallpox epidemic 1885 Montreal, Canada Smallpox 3,164 [172]
1889–1890 pandemic 1889–1890 Worldwide Influenza or Human coronavirus OC43 / HCoV-OC43[18][173] (disputed) 1 million [174]
1894 Hong Kong plague (part of the third plague pandemic) 1894–1929 Hong Kong Bubonic plague 20,000+ [175]
Bombay plague epidemic (part of the third plague pandemic) 1896–1905 Bombay, India Bubonic plague 20,788 [176]
1896–1906 Congo Basin African trypanosomiasis epidemic 1896–1906 Congo Basin African trypanosomiasis 500,000 [177]
1899 Porto plague outbreak (part of the third plague pandemic) 1899 Porto, Portugal Bubonic plague 132 [178]
Sixth cholera pandemic 1899–1923 Europe, Asia, Africa Cholera 800,000+ [179]
San Francisco plague of 1900–1904 (part of the third plague pandemic) 1900–1904 San Francisco, United States Bubonic plague 119 [180]
1900 Sydney bubonic plague epidemic (part of the third plague pandemic) 1900 Australia Bubonic plague 103 [181]
1900–1920 Uganda African trypanosomiasis epidemic 1900–1920 Uganda African trypanosomiasis 200,000–300,000 [177]
Papua New Guinea kuru epidemic 1901–2009 Papua New Guinea Kuru 2,700–3,000+ [182][183]
1903 Fremantle plague epidemic (part of the third plague pandemic) 1903 Fremantle, Western Australia Bubonic plague 4 [184]
1906 malaria outbreak in Ceylon 1906–1936 Ceylon Malaria 80,000 [185]
Manchurian plague (part of the third plague pandemic) 1910–1911 China Pneumonic plague 60,000 [186]
1916 United States polio epidemic 1916 United States Poliomyelitis 7,130 [187]
1918 influenza pandemic ('Spanish flu') 1918–1920 Worldwide Influenza A virus subtype H1N1
 
H1N1 virus
 17–100 million [188][189][190]
1918–1922 Russia typhus epidemic 1918–1922 Russia Typhus 2–3 million [191]
1919–1930 encephalitis lethargica epidemic 1919–1930 Worldwide Encephalitis lethargica 500,000 [192][193][194]
1924 Los Angeles pneumonic plague outbreak 1924 Los Angeles, United States Pneumonic plague 30 [195]
1924–1925 Minnesota smallpox epidemic 1924–1925 Minnesota, United States Smallpox 500 [196]
1927 Montreal typhoid fever epidemic 1927 Montreal, Canada Typhoid fever 538 [197]
1929–1930 psittacosis pandemic 1929–1930 Worldwide Psittacosis 100+ [198]
Croydon typhoid outbreak of 1937 1937 Croydon, United Kingdom Typhoid fever 43 [199]
1937 Australia polio epidemic 1937 Australia Poliomyelitis Unknown [200]
1940 Sudan yellow fever epidemic 1940 Sudan Yellow fever 1,627 [201]
1942–1944 Egypt malaria epidemic 1942–1944 Egypt Malaria Unknown [143][202]
1946 Egypt relapsing fever epidemic 1946 Egypt Relapsing fever Unknown [143][202]
1947 Egypt cholera epidemic 1947 Egypt Cholera 10,277 [143][202][203]
1948–1952 United States polio epidemic 1948–1952 United States Poliomyelitis 9,000 [187]
1957–1958 influenza pandemic ('Asian flu') 1957–1958 Worldwide Influenza A virus subtype H2N2 1–4 million [188][204][205]
1960–1962 Ethiopia yellow fever epidemic 1960–1962 Ethiopia Yellow fever 30,000 [206]
Seventh cholera pandemic 1961–1975 Worldwide Cholera (El Tor strain) 36,000[citation needed] [207]
Hong Kong flu 1968–1970 Worldwide Influenza A virus subtype H3N2
 
H3N2 virus
 1–4 million [188][204][205]
1971 Staphorst polio epidemic 1971 Staphorst, Netherlands Poliomyelitis 5 [208]
1972 Yugoslav smallpox outbreak 1972 Yugoslavia Smallpox 35 [209]
London flu 1972–1973 United States Influenza A virus subtype H3N2 1,027 [210]
1973 Italy cholera epidemic 1973 Italy Cholera (El Tor strain) 24 [211]
1974 smallpox epidemic in India 1974 India Smallpox 15,000 [212]
1977 Russian flu 1977–1979 Worldwide Influenza A virus subtype H1N1 700,000 [213][214]
Sverdlovsk anthrax leak 1979 Russia Anthrax 105 [215]
HIV/AIDS epidemic 1981–present Worldwide HIV/AIDS
 
Human immunodeficiency virus
 42 million (as of 2023) [216]
1984 Western Sahara plague 1984 Western Sahara Bubonic plague 64 [citation needed]
1986 Oju yellow fever epidemic 1986 Oju, Nigeria Yellow fever 5,600+ [217]
1987 Mali yellow fever epidemic 1987 Mali Yellow fever 145 [218]
1988 Shanghai hepatitis A epidemic 1988 Shanghai, China Hepatitis A 31–47 [219][220][221]
1991 Bangladesh cholera epidemic 1991 Bangladesh Cholera 8,410–9,432 [222]
1991 Latin America cholera epidemic 1991–1993 Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala Cholera 8,000 [223][224]
1994 plague in India 1994 India Bubonic plague and Pneumonic plague 56 [225]
United Kingdom BSE outbreak 1996–2001 United Kingdom Variant Creutzfeldt–Jakob disease / vCJD 178 [226][227]
1996 West Africa meningitis epidemic 1996 West Africa Meningitis 10,000 [228]
1998–1999 Malaysia Nipah virus outbreak 1998–1999 Malaysia Nipah virus infection 105 [229]
1998–2000 Democratic Republic of the Congo Marburg virus outbreak 1998–2000 Democratic Republic of the Congo Marburg virus 128 [230]
2000 Central America dengue epidemic 2000 Central America Dengue fever 40+ [231]
2001 Nigeria cholera epidemic 2001 Nigeria Cholera 400+ [232]
2001 South Africa cholera epidemic 2001 South Africa Cholera 139 [233][234]
2002–2004 SARS outbreak 2002–2004 Worldwide Severe acute respiratory syndrome / SARS 774 [235]
2003–2019 Asia and Egypt avian influenza epidemic 2003–2019 China, Southeast Asia and Egypt Influenza A virus subtype H5N1 455 [236]
2004 Indonesia dengue epidemic 2004 Indonesia Dengue fever 658 [237]
2004 Sudan Ebola outbreak 2004 Sudan Ebola 7 [238]
2004–2005 Angola Marburg virus outbreak 2004–2005 Angola Marburg virus 227 [230]
2005 dengue outbreak in Singapore 2005 Singapore Dengue fever 27 [239]
2006 Luanda cholera epidemic 2006 Luanda, Angola Cholera 1,200+ [240]
2006 Ituri Province plague epidemic 2006 Ituri Province, Democratic Republic of the Congo Bubonic plague 61 [241][242]
2006 India malaria outbreak 2006 India Malaria 17 [243]
2006 dengue outbreak in India 2006 India Dengue fever 50+ [244]
2006 dengue outbreak in Pakistan 2006 Pakistan Dengue fever 50+ [245]
2006 Philippines dengue epidemic 2006 Philippines Dengue fever 1,000 [246]
2006–2007 East Africa Rift Valley fever outbreak 2006–2007 East Africa Rift Valley fever 394 [247]
Mweka Ebola epidemic 2007 Democratic Republic of the Congo Ebola 187 [248]
2007 Ethiopia cholera epidemic 2007 Ethiopia Cholera 684 [249]
2007 Iraq cholera outbreak 2007 Iraq Cholera 10 [250]
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic 2007 Puerto Rico, Dominican Republic, Mexico Dengue fever 183 [251]
2007 Uganda Ebola outbreak 2007 Uganda Ebola 37 [238]
2007 Netherlands Q-fever epidemic 2007–2018 Netherlands Q-fever 95 [252]
2008 Brazil dengue epidemic 2008 Brazil Dengue fever 67 [253]
2008 Cambodia dengue epidemic 2008 Cambodia Dengue fever 407 [254]
2008 Chad cholera epidemic 2008 Chad Cholera 123 [255]
2008–2017 China hand, foot, and mouth disease epidemic 2008–2017 China Hand, foot, and mouth disease 3,322+ [256]
2008 India cholera epidemic 2008 India Cholera 115 [257]
2008 Madagascar plague outbreak 2008 Madagascar Bubonic plague 18+ [258]
2008 Philippines dengue epidemic 2008 Philippines Dengue fever 172 [259]
2008 Zimbabwean cholera outbreak 2008–2009 Zimbabwe Cholera 4,293 [260]
2009 Bolivian dengue fever epidemic 2009 Bolivia Dengue fever 18 [261]
2009 Gujarat hepatitis outbreak 2009 India Hepatitis B 49 [262]
Queensland 2009 dengue outbreak 2009 Queensland, Australia Dengue fever 1+ (503 cases) [263]
2009–2010 West African meningitis outbreak 2009–2010 West Africa Meningitis 1,100 [264]
2009 swine flu pandemic 2009–2010 Worldwide Influenza A virus subtype H1N1 Lab confirmed deaths: 18,449 (reported to the WHO) [265]
Estimated death toll: 284,000 (possible range 151,700–575,400) [266]
2010s Haiti cholera outbreak 2010–2019 Haiti Cholera (strain serogroup O1, serotype Ogawa) 10,075 [267]
2010–2014 Democratic Republic of the Congo measles outbreak 2010–2014 Democratic Republic of the Congo Measles 4,500+ [268][269]
2011 Vietnam hand, foot, and mouth disease epidemic 2011 Vietnam Hand, foot, and mouth disease 170 [270][271]
2011 dengue outbreak in Pakistan 2011 Pakistan Dengue fever 350+ [272]
2012 yellow fever outbreak in Darfur, Sudan 2012 Darfur, Sudan Yellow fever 171 [273]
2012 Middle East respiratory syndrome coronavirus outbreak 2012–2021 Worldwide Middle East respiratory syndrome / MERS-CoV 941 (as of 8 May 2021) [274][275]
2013 dengue outbreak in Singapore 2013 Singapore Dengue fever 8
2013 Vietnam measles outbreak 2013–2014 Vietnam Measles 142 [276]
Western African Ebola virus epidemic 2013–2016 Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone Ebola
 
Ebola virus virion
 11,323+ [277][278][279]
2013–2014 chikungunya outbreak 2013–2015 Americas Chikungunya 183 [280]
2013–19 avian influenza epidemic 2013–2019 China Influenza A virus subtype H7N9 616 [281]
21st century Madagascar plague outbreaks 2014–2017 Madagascar Bubonic plague 292 [282]
Flint water crisis 2014–2015 Flint, Michigan, United States Legionnaires' disease 12 [283]
2014 Odisha hepatitis outbreak 2014–2015 India Primarily Hepatitis E, but also Hepatitis A 36 [284]
2015 Indian swine flu outbreak 2015 India Influenza A virus subtype H1N1 2,035 [285][286][287]
2015–16 Zika virus epidemic 2015–2016 Worldwide Zika virus 53 [288]
2016 Angola and Democratic Republic of the Congo yellow fever outbreak 2016 Angola and Democratic Republic of the Congo Yellow fever 498 (377 in Angola, 121 in Congo) [289]
2016–2022 Yemen cholera outbreak 2016–2023 Yemen Cholera 4,004 (as of June 11, 2023) [290]
2017 Nigeria Lassa fever epidemic 2017–2023 Nigeria Lassa fever 1103 (as of April 2023) [291]
2017 dengue outbreak in Peshawar 2017 Peshawar, Pakistan Dengue fever 69 [292]
2017 Gorakhpur hospital deaths 2017 India Japanese encephalitis 1,317 [293]
2017 dengue outbreak in Sri Lanka 2017 Sri Lanka Dengue fever 440 [294]
2018 Nipah virus outbreak in Kerala 2018 India Nipah virus infection 17 [295]
Kivu Ebola epidemic 2018–2020 Democratic Republic of the Congo and Uganda Ebola 2,280 [296][297][298]
2018 NDM-CRE outbreak in Italy 2018–2019 Italy New Delhi metallo-beta-lactamase-producing Carbapenem-resistant enterobacteriaceae 31 (as of September 2019) [299]
2019–2020 measles outbreak in the Democratic Republic of the Congo 2019–2020 Democratic Republic of the Congo Measles 7,018+ [300]
2019–2020 New Zealand measles outbreak 2019–2020 New Zealand Measles 2 [301]
2019 measles outbreak in the Philippines 2019 Philippines Measles 415 [302]
2019 Kuala Koh measles outbreak 2019 Kuala Koh, Malaysia Measles 15 [303]
2019 Samoa measles outbreak 2019 Samoa Measles 83 [304]
2019–2020 dengue fever epidemic 2019–2020 Asia-Pacific, Latin America Dengue fever 3,931 [305]
COVID-19 pandemic 2019[e]–present Worldwide COVID-19
 
SARS-CoV-2 virus
 7–36.6 million [307][308][309][310]
2020 Democratic Republic of the Congo Ebola outbreak 2020 Democratic Republic of the Congo Ebola 55 [311]
2020 dengue outbreak in Singapore 2020 Singapore Dengue fever 32 [312]
2020 Nigeria yellow fever epidemic 2020 Nigeria Yellow fever 296 (as of 31 December 2020) [313]
2021 India black fungus epidemic 2021–2022 India Black fungus (COVID-19 condition) 4,332 [314]
2022 hepatitis of unknown origin in children 2021–2022 Worldwide Hepatitis by Adenovirus variant AF41 (Unconfirmed) 18 [315][316][317]
2022–2023 mpox outbreak 2022–2023 Worldwide Monkeypox virus 280 [318][319][320][321]
2022 Uganda Ebola outbreak 2022–2023 Uganda Sudan ebolavirus 77 [322]
2023 South Poland Legionellosis outbreak 2023 Poland Legionella 23 [323][324]

See also

Explanatory notes

  1. ^ a b c d The estimates of global population at the time vary non-trivially (no consensus). The current estimates are based on the available population data from estimates of historical world population and the sources in these footnotes:[3][4]
  2. ^ a b Global population changed significantly (not due to the epidemic) during the period of this epidemic.
  3. ^ Epidemic typhus was not limited to Russia and several million citizens died in Poland and Romania. However, due to lack of exact data, only the Russian epidemic is included.
  4. ^ a b c No accurate data about the local population at the time of this epidemic
  5. ^ The COVID-19 pandemic started as a regional outbreak/epidemic of COVID-19 in China in late 2019. The World Health Organization referred to it as a "pandemic" on 11 March 2020.[306] The starting time of this epidemic is thus 2019, regardless of the time when it was formally recognized as a pandemic.

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February 15, 2024
list, epidemics, pandemics, this, list, largest, known, epidemics, pandemics, caused, infectious, disease, widespread, communicable, diseases, such, cardiovascular, disease, cancer, included, epidemic, rapid, spread, disease, large, number, people, given, popu. This is a list of the largest known epidemics and pandemics caused by an infectious disease Widespread non communicable diseases such as cardiovascular disease and cancer are not included An epidemic is the rapid spread of disease to a large number of people in a given population within a short period of time in meningococcal infections an attack rate in excess of 15 cases per 100 000 people for two consecutive weeks is considered an epidemic 1 Due to the long time spans the first plague pandemic 6th century 8th century and the second plague pandemic 14th century early 19th century are shown by individual outbreaks such as the Plague of Justinian first pandemic and the Black Death second pandemic Pandemics timeline death tollsInfectious diseases with high prevalence are listed separately sometimes in addition to their epidemics such as malaria which may have killed 50 60 billion people throughout history or about half of all humans that have ever lived 2 Contents 1 Major epidemics and pandemics 1 1 By death toll 1 2 Depopulation of the Americas 1 3 Infectious diseases with high prevalence 2 Chronology 3 See also 4 Explanatory notes 5 References 6 Further reading 7 External linksMajor epidemics and pandemicsBy death toll Ongoing epidemics and pandemics are in boldface For a given epidemic or pandemic the average of its estimated death toll range is used for ranking If the death toll averages of two or more epidemics or pandemics are equal then the smaller the range the higher the rank For the historical records of major changes in the world population see world population 3 4 Epidemics and pandemics with at least 1 million deaths Rank Epidemics pandemics Disease Death toll Global population lost Regional population lost Years Location1 Black Death Bubonic plague 25 50 million 17 54 a 30 60 of European population 5 1346 1353 Europe Asia and North Africa2 Spanish flu Influenza A H1N1 17 100 million 1 5 4 6 7 1918 1920 Worldwide3 Plague of Justinian Bubonic plague 15 100 million 7 56 a 25 60 of European population 8 541 549 North Africa Europe and Western Asia4 HIV AIDS epidemic HIV AIDS 43 million as of 2024 update b 1981 present 9 Worldwide5 COVID 19 pandemic COVID 19 7 21 million 10 11 as of January 2024 update 0 1 0 46 3 better source needed 2019 present 12 Worldwide6 Third plague pandemic Bubonic plague 12 15 million b 1855 1960 Worldwide7 Cocoliztli epidemic of 1545 1548 Cocoliztli caused by an unidentified pathogen 5 15 million 1 3 a 27 80 of Mexican population 13 1545 1548 Mexico8 Antonine Plague Smallpox or measles 5 10 million 3 6 4 25 33 of Roman population 14 165 180 possibly up to 190 Roman Empire9 1520 Mexico smallpox epidemic Smallpox 5 8 million 1 2 a 23 37 of Mexican population 13 1519 1520 Mexico10 1918 1922 Russia typhus epidemic Typhus 2 3 million 0 1 0 16 7 c 1 1 6 of Russian population 15 1918 1922 Russia11 1957 1958 influenza pandemic Influenza A H2N2 1 4 million 0 03 0 1 3 1957 1958 Worldwide12 Hong Kong flu Influenza A H3N2 1 4 million 0 03 0 1 3 1968 1969 Worldwide13 Cocoliztli epidemic of 1576 Cocoliztli 2 2 5 million 0 4 0 5 4 50 of Mexican population 13 1576 1580 Mexico14 735 737 Japanese smallpox epidemic Smallpox 2 million 1 4 33 of Japanese population 16 735 737 Japan15 1772 1773 Persian Plague Bubonic plague 2 million 0 2 0 3 4 d 1772 1773 Persia16 Naples Plague Bubonic plague 1 25 million 0 2 4 d 1656 1658 Southern Italy17 1846 1860 cholera pandemic Cholera 1 million 0 08 4 1846 1860 Worldwide18 1629 1631 Italian plague Bubonic plague 1 million 0 2 4 d 1629 1631 Italy19 1889 1890 flu pandemic Influenza disputed 17 18 1 million 0 07 4 1889 1890 WorldwideDepopulation of the Americas Main article Population history of Indigenous peoples of the Americas Depopulation by Old World diseases Not included in the above table are many waves of deadly diseases brought by Europeans to the Americas and Caribbean Western Hemisphere populations were ravaged mostly by smallpox but also typhus measles influenza bubonic plague cholera malaria tuberculosis mumps yellow fever and pertussis The lack of written records in many places and the destruction of many native societies by disease war and colonization make estimates uncertain Deaths probably numbered in the tens or perhaps over a hundred million with perhaps 90 of the population dead in the worst hit areas Lack of scientific knowledge about microorganisms and lack of surviving medical records for many areas makes attribution of specific numbers to specific diseases uncertain Infectious diseases with high prevalence Further information List of causes of death by rate There have been various major infectious diseases with high prevalence worldwide but they are currently not listed in the above table as epidemics pandemics due to the lack of definite data such as time span and death toll nbsp An Ethiopian child with malaria a disease with an annual death rate of 619 000 as of 2021 19 Malaria has had multiple documented temporary epidemics in otherwise non affected or low prevalence areas but the vast majority of its deaths are due to its constant prevalence in affected areas 2 Tuberculosis TB became epidemic in Europe in the 18th and 19th century showing a seasonal pattern and is still taking place globally 20 21 22 The morbidity and mortality of TB and HIV AIDS have been closely linked known as TB HIV syndemic 22 23 According to the World Health Organization approximately 10 million new TB infections occur every year and 1 5 million people die from it each year making it the world s top infectious killer before COVID 19 pandemic 22 However there is a lack of sources which describe major TB epidemics with definite time spans and death tolls Hepatitis B According to the World Health Organization as of 2019 update there are about 296 million people living with chronic hepatitis B with 1 5 million new infections each year In 2019 hepatitis B caused about 820 000 deaths mostly from cirrhosis and hepatocellular carcinoma primary liver cancer 24 In many places of Asia and Africa hepatitis B has become endemic 25 In addition a person is sometimes infected with both hepatitis B virus HBV and HIV and this population about 2 7 million accounts for about 1 of the total HBV infections 24 Hepatitis C According to the World Health Organization there are approximately 58 million people with chronic hepatitis C with about 1 5 million new infections occurring per year In 2019 approximately 290 000 people died from the disease mostly from cirrhosis and hepatocellular carcinoma primary liver cancer 26 There have been many hepatitis C virus HCV epidemics in history 27 28 29 ChronologyEvents in boldface are ongoing Chronological table of epidemic and pandemic events in human history Event Years Location Disease Death toll estimate Ref 1350 BC plague of Megiddo 1350 BC Megiddo land of Canaan Amarna letters EA 244 Biridiya mayor of Megiddo complains to Amenhotep III of his area being consumed by death plague and dust Unknown 30 Plague of Athens 430 426 BC Greece Libya Egypt Ethiopia Unknown possibly typhus typhoid fever or viral hemorrhagic fever 75 000 100 000 31 32 33 34 412 BC epidemic 412 BC Greece Northern Greece Roman Republic Unknown possibly influenza 473 000 10 of the Roman Population 35 Antonine Plague 165 180 possibly up to 190 Roman Empire Unknown possibly smallpox 5 10 million 36 37 Jian an Plague 217 Han Dynasty Unknown possibly typhoid fever or viral hemorrhagic fever 2 Million 38 39 Plague of Cyprian 249 262 Europe Unknown possibly smallpox 310 000 40 41 Plague of Justinian beginning of first plague pandemic 541 549 Europe and West Asia Bubonic plague 15 100 million 8 42 43 580 Dysentery Epidemic in Gaul 580 Gaul Dysentery or possibly smallpox 450 000 10 of the Gaul population 44 Roman Plague of 590 part of first plague pandemic 590 Rome Byzantine Empire Bubonic plague Unknown 45 Plague of Sheroe part of first plague pandemic 627 628 Bilad al Sham Bubonic plague 25 000 Plague of Amwas part of first plague pandemic 638 639 Byzantine Empire West Asia Africa Bubonic plague 25 000 46 Plague of 664 part of first plague pandemic 664 689 British Isles Bubonic plague Unknown 47 Plague of 698 701 part of first plague pandemic 698 701 Byzantine Empire West Asia Syria Mesopotamia Bubonic plague Unknown 48 735 737 Japanese smallpox epidemic 735 737 Japan Smallpox 2 million approx 1 3 of Japanese population 16 49 Plague of 746 747 part of first plague pandemic 746 747 Byzantine Empire West Asia Africa Bubonic plague Unknown 46 Black Death start of the second plague pandemic 1346 1353 Eurasia and North Africa Bubonic plague 75 200 million 30 60 of European population and 33 percent of the Middle Eastern population 50 Sweating sickness multiple outbreaks 1485 1551 Britain England and later continental Europe Unknown possibly an unknown species of hantavirus 10 000 51 1489 Spain typhus epidemic 1489 Spain Typhus 17 000 52 1510 influenza pandemic 1510 Asia North Africa Europe Influenza Unknown around 1 of those infected 53 1520 Mexico smallpox epidemic 1519 1520 Mexico Smallpox 5 8 million 40 of population 13 Cocoliztli epidemic of 1545 1548 1545 1548 Mexico Possibly Salmonella enterica 5 15 million 80 of population 54 55 56 57 1557 influenza pandemic 1557 1559 Asia Africa Europe and Americas Influenza 2 5 5 Million 10 of the infected 1561 Chile smallpox epidemic 1561 1562 Chile Smallpox 120 000 150 000 20 25 of native population 58 1563 London plague part of the second plague pandemic 1563 1564 London England Bubonic plague 20 100 59 Cocoliztli epidemic of 1576 1576 1580 Mexico Possibly Salmonella enterica 2 2 5 million 50 of population 54 55 56 57 1582 Tenerife plague epidemic part of the second plague pandemic 1582 1583 Tenerife Spain Bubonic plague 5 000 9 000 60 1592 1596 Seneca nation measles epidemic 1592 1596 Seneca nation North America Measles Unknown 61 1592 1593 Malta plague epidemic part of the second plague pandemic 1592 1593 Malta Bubonic plague 3 000 62 1592 1593 London plague part of the second plague pandemic 1592 1593 London England Bubonic plague 19 900 63 1596 1602 Spain plague epidemic part of the second plague pandemic 1596 1602 Spain Bubonic plague 600 000 700 000 64 1600 1650 South America malaria epidemic 1600 1650 South America Malaria Unknown citation needed 1603 London plague part of the second plague pandemic 1603 London England Bubonic plague 40 000 65 66 67 1616 New England infections epidemic 1616 1620 Southern New England British North America especially the Wampanoag people Unknown possibly leptospirosis with Weil syndrome Classic explanations include yellow fever bubonic plague influenza smallpox chickenpox typhus and syndemic infection of hepatitis B and hepatitis D 1 143 000 3 429 000 estimated 30 90 of population 68 69 1629 1631 Italian plague part of the second plague pandemic 1629 1631 Italy Bubonic plague 1 million 70 1632 1635 Augsburg plague epidemic part of the second plague pandemic 1632 1635 Augsburg Germany Bubonic plague 13 712 71 Massachusetts smallpox epidemic 1633 1634 Massachusetts Bay Colony Thirteen Colonies Smallpox 1 000 72 1634 1640 Wyandot people epidemic 1634 1640 Wyandot people North America Smallpox and Influenza 15 000 25 000 73 1637 London plague epidemic part of the second plague pandemic 1636 1637 London and Westminster England Bubonic plague 10 400 74 Great Plague in the late Ming dynasty part of the second plague pandemic 1633 1644 China Bubonic plague 200 000 75 76 Great Plague of Seville part of the second plague pandemic 1647 1652 Spain Bubonic plague 500 000 77 1648 Central America yellow fever epidemic 1648 Central America Yellow fever Unknown 78 Naples Plague part of the second plague pandemic 1656 1658 Italy Bubonic plague 1 250 000 79 1663 1664 Amsterdam plague epidemic part of the second plague pandemic 1663 1664 Amsterdam Netherlands Bubonic plague 24 148 80 Great Plague of London part of the second plague pandemic 1665 1666 England Bubonic plague 100 000 81 82 1668 France plague part of the second plague pandemic 1668 France Bubonic plague 40 000 83 1675 1676 Malta plague epidemic part of the second plague pandemic 1675 1676 Malta Bubonic plague 11 300 84 1676 1685 Spain plague part of the second plague pandemic 1676 1685 Spain Bubonic plague Unknown 85 1677 1678 Boston smallpox epidemic 1677 1678 Massachusetts Bay Colony British North America Smallpox 750 1 000 86 Great Plague of Vienna part of the second plague pandemic 1679 Vienna Austria Bubonic plague 76 000 87 1681 Prague plague epidemic part of the second plague pandemic 1681 Prague Czech Kingdom Bubonic plague 83 000 88 1687 South Africa influenza outbreak 1687 South Africa Unknown possibly influenza Unknown 89 1693 Boston yellow fever epidemic 1693 Boston Massachusetts Bay Colony British North America Yellow fever 3 100 90 1699 Charleston and Philadelphia yellow fever epidemic 1699 Charleston and Philadelphia British North America Yellow fever 520 300 in Charleston 220 in Philadelphia 91 1702 New York City yellow fever epidemic 1702 New York City British North America Yellow fever 500 92 1702 1703 St Lawrence Valley smallpox epidemic 1702 1703 New France Canada Smallpox 1 300 93 1707 1708 Iceland smallpox epidemic 1707 1709 Iceland Smallpox 18 000 36 of population 94 Great Northern War plague outbreak part of the second plague pandemic 1710 1712 Denmark Sweden Lithuania Bubonic plague 164 000 95 96 1713 1715 North America measles epidemic 1713 1715 Thirteen Colonies and New France Canada Measles Unknown 97 98 Great Plague of Marseille part of the second plague pandemic 1720 1722 France Bubonic plague 100 000 99 1721 Boston smallpox outbreak 1721 1722 Massachusetts Bay Colony Smallpox 844 100 1730 Cadiz yellow fever epidemic 1730 Cadiz Spain Yellow fever 2 200 101 1732 1733 Thirteen Colonies influenza epidemic 1732 1733 Thirteen Colonies Influenza Unknown 102 1733 New France smallpox epidemic 1733 New France Canada Smallpox Unknown 103 1735 1741 diphtheria epidemic 1735 1741 New England Province of New York Province of New Jersey British North America Diphtheria 20 000 104 Great Plague of 1738 part of the second plague pandemic 1738 Balkans Bubonic plague 50 000 105 1738 1739 North Carolina smallpox epidemic 1738 1739 Province of Carolina Thirteen Colonies Smallpox 7 700 11 700 106 1741 Cartagena yellow fever epidemic 1741 Cartagena Colombia Yellow fever 20 000 107 1743 Sicily plague epidemic part of the second plague pandemic 1743 Messina Sicily Italy Bubonic plague 40 000 50 000 108 109 1759 North America measles outbreak 1759 North America Measles Unknown 110 1760 Charleston smallpox epidemic 1760 Charleston British North America Smallpox 730 940 111 112 1762 Havana yellow fever epidemic 1762 Havana Cuba Yellow fever 8 000 107 1763 Pittsburgh area smallpox outbreak 1763 North America present day Pittsburgh area Smallpox Unknown 113 1770 1772 Russian plague part of the second plague pandemic 1770 1772 Russia Bubonic plague 50 000 114 1772 North America measles epidemic 1772 North America Measles 1 080 115 1772 1773 Persian Plague part of the second plague pandemic 1772 1773 Persia Bubonic plague 2 million 116 1775 1776 England influenza outbreak 1775 1776 England Influenza Unknown 117 1775 1782 North American smallpox epidemic 1775 1782 Native populations in what is now the Pacific Northwest of the United States Smallpox 11 000 118 119 1778 Spain dengue fever outbreak 1778 Spain Dengue fever Unknown 120 1782 Influenza pandemic 1782 Worldwide Influenza Unknown1788 Pueblo Indians smallpox epidemic 1788 Pueblo Indians in northern New Spain what is now the Southwestern United States Smallpox Unknown 121 1789 1790 New South Wales smallpox epidemic 1789 1790 New South Wales Australia Smallpox 125 251 175 351 50 70 of native population 122 123 1793 Philadelphia yellow fever epidemic 1793 Philadelphia United States Yellow fever 5 000 124 1800 1803 Spain yellow fever epidemic 1800 1803 Spain Yellow fever 60 000 125 1801 Ottoman Empire and Egypt bubonic plague epidemic 1801 Ottoman Empire Egypt Bubonic plague Unknown 126 1802 1803 Saint Domingue yellow fever epidemic 1802 1803 Saint Domingue Yellow fever 29 000 55 000 127 1812 Russia typhus epidemic 1812 Russia Typhus 300 000 52 1812 1819 Ottoman plague epidemic part of the second plague pandemic 1812 1819 Ottoman Empire Bubonic plague 300 000 128 1813 1814 Malta plague epidemic part of the second plague pandemic 1813 1814 Malta Bubonic plague 4 500 129 Caragea s plague part of the second plague pandemic 1813 Romania Bubonic plague 60 000 130 1817 1819 Ireland typhus epidemic 1817 1819 Ireland Typhus 65 000 131 First cholera pandemic 1817 1824 Asia Europe Cholera 100 000 132 1820 Savannah yellow fever epidemic 1820 Savannah Georgia United States Yellow fever 700 133 1821 Barcelona yellow fever epidemic 1821 Barcelona Spain Yellow fever 5 000 20 000 134 135 Second cholera pandemic 1826 1837 Asia Europe North America Cholera 100 000 136 1828 1829 New South Wales smallpox epidemic 1828 1829 New South Wales Australia Smallpox 19 000 137 138 Groningen epidemic 1829 Netherlands Malaria 2 800 139 1829 1833 Pacific Northwest malaria epidemic 1829 1833 Pacific Northwest United States Malaria possibly other diseases too 150 000 140 141 1829 1835 Iran plague outbreak 1829 1835 Iran Bubonic plague Unknown 142 1834 1836 Egypt plague epidemic 1834 1836 Egypt Bubonic plague Unknown 143 1837 Great Plains smallpox epidemic 1837 1838 Great Plains United States and Canada Smallpox 17 000 144 1841 Southern United States yellow fever epidemic 1841 Southern United States especially Louisiana and Florida Yellow fever 3 498 145 1847 North American typhus epidemic 1847 1848 Canada Typhus 20 000 146 1847 Southern United States yellow fever epidemic 1847 Southern United States especially New Orleans Yellow fever 3 400 147 1847 1848 influenza epidemic 1847 1848 Worldwide Influenza Unknown 148 1848 1849 Hawaii epidemic of infections 1848 1849 Hawaiian Kingdom Measles whooping cough dysentery and influenza 10 000 149 1853 New Orleans yellow fever epidemic 1853 New Orleans United States Yellow fever 7 970 134 Third cholera pandemic 1846 1860 Worldwide Cholera 1 million 150 1853 Ottoman Empire plague epidemic 1853 Ottoman Empire Bubonic plague Unknown 151 1853 Copenhagen cholera outbreak 1853 Copenhagen Denmark Cholera 4 737 152 1854 Broad Street cholera outbreak 1854 London England Cholera 616 153 1855 Norfolk yellow fever epidemic 1855 Norfolk and Portsmouth England Yellow fever 3 000 2 000 in Norfolk 1 000 in Portsmouth 154 Third plague pandemic 1855 1960 Worldwide Bubonic plague 12 15 million India and China 155 156 1855 1857 Montevideo yellow fever epidemic 1855 1857 Montevideo Uruguay Yellow fever 3 400 first wave 900 second wave 2 500 157 1857 Lisbon yellow fever epidemic 1857 Lisbon Portugal Yellow fever 6 000 134 1857 Victoria smallpox epidemic 1857 Victoria Australia Smallpox Unknown 158 1857 1859 Europe and the Americas influenza epidemic 1857 1859 Europe North America South America Influenza Unknown 159 1862 Pacific Northwest smallpox epidemic 1862 1863 Pacific Northwest Canada and United States Smallpox 20 000 160 161 162 1861 1865 United States typhoid fever epidemic 1861 1865 United States Typhoid fever 80 000 163 Fourth cholera pandemic 1863 1875 Middle East Cholera 600 000 164 1867 Sydney measles epidemic 1867 Sydney Australia Measles 748 165 1871 Buenos Aires yellow fever epidemic 1871 Buenos Aires Argentina Yellow fever 13 500 26 200 166 1870 1875 Europe smallpox epidemic 1870 1875 Europe Smallpox 500 000 167 168 1875 Fiji measles outbreak 1875 Fiji Measles 40 000 169 1875 1876 Australia scarlet fever epidemic 1875 1876 Australia Scarlet fever 8 000 165 1876 Ottoman Empire plague epidemic 1876 Ottoman Empire Bubonic plague 20 000 170 1878 New Orleans yellow fever epidemic 1878 New Orleans United States Yellow fever 4 046 127 1878 Mississippi Valley yellow fever epidemic 1878 Mississippi Valley United States Yellow fever 13 000 127 Fifth cholera pandemic 1881 1896 Asia Africa Europe South America Cholera 298 600 171 1885 Montreal smallpox epidemic 1885 Montreal Canada Smallpox 3 164 172 1889 1890 pandemic 1889 1890 Worldwide Influenza or Human coronavirus OC43 HCoV OC43 18 173 disputed 1 million 174 1894 Hong Kong plague part of the third plague pandemic 1894 1929 Hong Kong Bubonic plague 20 000 175 Bombay plague epidemic part of the third plague pandemic 1896 1905 Bombay India Bubonic plague 20 788 176 1896 1906 Congo Basin African trypanosomiasis epidemic 1896 1906 Congo Basin African trypanosomiasis 500 000 177 1899 Porto plague outbreak part of the third plague pandemic 1899 Porto Portugal Bubonic plague 132 178 Sixth cholera pandemic 1899 1923 Europe Asia Africa Cholera 800 000 179 San Francisco plague of 1900 1904 part of the third plague pandemic 1900 1904 San Francisco United States Bubonic plague 119 180 1900 Sydney bubonic plague epidemic part of the third plague pandemic 1900 Australia Bubonic plague 103 181 1900 1920 Uganda African trypanosomiasis epidemic 1900 1920 Uganda African trypanosomiasis 200 000 300 000 177 Papua New Guinea kuru epidemic 1901 2009 Papua New Guinea Kuru 2 700 3 000 182 183 1903 Fremantle plague epidemic part of the third plague pandemic 1903 Fremantle Western Australia Bubonic plague 4 184 1906 malaria outbreak in Ceylon 1906 1936 Ceylon Malaria 80 000 185 Manchurian plague part of the third plague pandemic 1910 1911 China Pneumonic plague 60 000 186 1916 United States polio epidemic 1916 United States Poliomyelitis 7 130 187 1918 influenza pandemic Spanish flu 1918 1920 Worldwide Influenza A virus subtype H1N1 nbsp H1N1 virus 17 100 million 188 189 190 1918 1922 Russia typhus epidemic 1918 1922 Russia Typhus 2 3 million 191 1919 1930 encephalitis lethargica epidemic 1919 1930 Worldwide Encephalitis lethargica 500 000 192 193 194 1924 Los Angeles pneumonic plague outbreak 1924 Los Angeles United States Pneumonic plague 30 195 1924 1925 Minnesota smallpox epidemic 1924 1925 Minnesota United States Smallpox 500 196 1927 Montreal typhoid fever epidemic 1927 Montreal Canada Typhoid fever 538 197 1929 1930 psittacosis pandemic 1929 1930 Worldwide Psittacosis 100 198 Croydon typhoid outbreak of 1937 1937 Croydon United Kingdom Typhoid fever 43 199 1937 Australia polio epidemic 1937 Australia Poliomyelitis Unknown 200 1940 Sudan yellow fever epidemic 1940 Sudan Yellow fever 1 627 201 1942 1944 Egypt malaria epidemic 1942 1944 Egypt Malaria Unknown 143 202 1946 Egypt relapsing fever epidemic 1946 Egypt Relapsing fever Unknown 143 202 1947 Egypt cholera epidemic 1947 Egypt Cholera 10 277 143 202 203 1948 1952 United States polio epidemic 1948 1952 United States Poliomyelitis 9 000 187 1957 1958 influenza pandemic Asian flu 1957 1958 Worldwide Influenza A virus subtype H2N2 1 4 million 188 204 205 1960 1962 Ethiopia yellow fever epidemic 1960 1962 Ethiopia Yellow fever 30 000 206 Seventh cholera pandemic 1961 1975 Worldwide Cholera El Tor strain 36 000 citation needed 207 Hong Kong flu 1968 1970 Worldwide Influenza A virus subtype H3N2 nbsp H3N2 virus 1 4 million 188 204 205 1971 Staphorst polio epidemic 1971 Staphorst Netherlands Poliomyelitis 5 208 1972 Yugoslav smallpox outbreak 1972 Yugoslavia Smallpox 35 209 London flu 1972 1973 United States Influenza A virus subtype H3N2 1 027 210 1973 Italy cholera epidemic 1973 Italy Cholera El Tor strain 24 211 1974 smallpox epidemic in India 1974 India Smallpox 15 000 212 1977 Russian flu 1977 1979 Worldwide Influenza A virus subtype H1N1 700 000 213 214 Sverdlovsk anthrax leak 1979 Russia Anthrax 105 215 HIV AIDS epidemic 1981 present Worldwide HIV AIDS nbsp Human immunodeficiency virus 42 million as of 2023 update 216 1984 Western Sahara plague 1984 Western Sahara Bubonic plague 64 citation needed 1986 Oju yellow fever epidemic 1986 Oju Nigeria Yellow fever 5 600 217 1987 Mali yellow fever epidemic 1987 Mali Yellow fever 145 218 1988 Shanghai hepatitis A epidemic 1988 Shanghai China Hepatitis A 31 47 219 220 221 1991 Bangladesh cholera epidemic 1991 Bangladesh Cholera 8 410 9 432 222 1991 Latin America cholera epidemic 1991 1993 Peru Chile Bolivia Ecuador Colombia Mexico El Salvador Guatemala Cholera 8 000 223 224 1994 plague in India 1994 India Bubonic plague and Pneumonic plague 56 225 United Kingdom BSE outbreak 1996 2001 United Kingdom Variant Creutzfeldt Jakob disease vCJD 178 226 227 1996 West Africa meningitis epidemic 1996 West Africa Meningitis 10 000 228 1998 1999 Malaysia Nipah virus outbreak 1998 1999 Malaysia Nipah virus infection 105 229 1998 2000 Democratic Republic of the Congo Marburg virus outbreak 1998 2000 Democratic Republic of the Congo Marburg virus 128 230 2000 Central America dengue epidemic 2000 Central America Dengue fever 40 231 2001 Nigeria cholera epidemic 2001 Nigeria Cholera 400 232 2001 South Africa cholera epidemic 2001 South Africa Cholera 139 233 234 2002 2004 SARS outbreak 2002 2004 Worldwide Severe acute respiratory syndrome SARS 774 235 2003 2019 Asia and Egypt avian influenza epidemic 2003 2019 China Southeast Asia and Egypt Influenza A virus subtype H5N1 455 236 2004 Indonesia dengue epidemic 2004 Indonesia Dengue fever 658 237 2004 Sudan Ebola outbreak 2004 Sudan Ebola 7 238 2004 2005 Angola Marburg virus outbreak 2004 2005 Angola Marburg virus 227 230 2005 dengue outbreak in Singapore 2005 Singapore Dengue fever 27 239 2006 Luanda cholera epidemic 2006 Luanda Angola Cholera 1 200 240 2006 Ituri Province plague epidemic 2006 Ituri Province Democratic Republic of the Congo Bubonic plague 61 241 242 2006 India malaria outbreak 2006 India Malaria 17 243 2006 dengue outbreak in India 2006 India Dengue fever 50 244 2006 dengue outbreak in Pakistan 2006 Pakistan Dengue fever 50 245 2006 Philippines dengue epidemic 2006 Philippines Dengue fever 1 000 246 2006 2007 East Africa Rift Valley fever outbreak 2006 2007 East Africa Rift Valley fever 394 247 Mweka Ebola epidemic 2007 Democratic Republic of the Congo Ebola 187 248 2007 Ethiopia cholera epidemic 2007 Ethiopia Cholera 684 249 2007 Iraq cholera outbreak 2007 Iraq Cholera 10 250 2007 Puerto Rico Dominican Republic and Mexico dengue fever epidemic 2007 Puerto Rico Dominican Republic Mexico Dengue fever 183 251 2007 Uganda Ebola outbreak 2007 Uganda Ebola 37 238 2007 Netherlands Q fever epidemic 2007 2018 Netherlands Q fever 95 252 2008 Brazil dengue epidemic 2008 Brazil Dengue fever 67 253 2008 Cambodia dengue epidemic 2008 Cambodia Dengue fever 407 254 2008 Chad cholera epidemic 2008 Chad Cholera 123 255 2008 2017 China hand foot and mouth disease epidemic 2008 2017 China Hand foot and mouth disease 3 322 256 2008 India cholera epidemic 2008 India Cholera 115 257 2008 Madagascar plague outbreak 2008 Madagascar Bubonic plague 18 258 2008 Philippines dengue epidemic 2008 Philippines Dengue fever 172 259 2008 Zimbabwean cholera outbreak 2008 2009 Zimbabwe Cholera 4 293 260 2009 Bolivian dengue fever epidemic 2009 Bolivia Dengue fever 18 261 2009 Gujarat hepatitis outbreak 2009 India Hepatitis B 49 262 Queensland 2009 dengue outbreak 2009 Queensland Australia Dengue fever 1 503 cases 263 2009 2010 West African meningitis outbreak 2009 2010 West Africa Meningitis 1 100 264 2009 swine flu pandemic 2009 2010 Worldwide Influenza A virus subtype H1N1 Lab confirmed deaths 18 449 reported to the WHO 265 Estimated death toll 284 000 possible range 151 700 575 400 266 2010s Haiti cholera outbreak 2010 2019 Haiti Cholera strain serogroup O1 serotype Ogawa 10 075 267 2010 2014 Democratic Republic of the Congo measles outbreak 2010 2014 Democratic Republic of the Congo Measles 4 500 268 269 2011 Vietnam hand foot and mouth disease epidemic 2011 Vietnam Hand foot and mouth disease 170 270 271 2011 dengue outbreak in Pakistan 2011 Pakistan Dengue fever 350 272 2012 yellow fever outbreak in Darfur Sudan 2012 Darfur Sudan Yellow fever 171 273 2012 Middle East respiratory syndrome coronavirus outbreak 2012 2021 Worldwide Middle East respiratory syndrome MERS CoV 941 as of 8 May 2021 update 274 275 2013 dengue outbreak in Singapore 2013 Singapore Dengue fever 82013 Vietnam measles outbreak 2013 2014 Vietnam Measles 142 276 Western African Ebola virus epidemic 2013 2016 Worldwide primarily concentrated in Guinea Liberia Sierra Leone Ebola nbsp Ebola virus virion 11 323 277 278 279 2013 2014 chikungunya outbreak 2013 2015 Americas Chikungunya 183 280 2013 19 avian influenza epidemic 2013 2019 China Influenza A virus subtype H7N9 616 281 21st century Madagascar plague outbreaks 2014 2017 Madagascar Bubonic plague 292 282 Flint water crisis 2014 2015 Flint Michigan United States Legionnaires disease 12 283 2014 Odisha hepatitis outbreak 2014 2015 India Primarily Hepatitis E but also Hepatitis A 36 284 2015 Indian swine flu outbreak 2015 India Influenza A virus subtype H1N1 2 035 285 286 287 2015 16 Zika virus epidemic 2015 2016 Worldwide Zika virus 53 288 2016 Angola and Democratic Republic of the Congo yellow fever outbreak 2016 Angola and Democratic Republic of the Congo Yellow fever 498 377 in Angola 121 in Congo 289 2016 2022 Yemen cholera outbreak 2016 2023 Yemen Cholera 4 004 as of June 11 2023 update 290 2017 Nigeria Lassa fever epidemic 2017 2023 Nigeria Lassa fever 1103 as of April 2023 291 2017 dengue outbreak in Peshawar 2017 Peshawar Pakistan Dengue fever 69 292 2017 Gorakhpur hospital deaths 2017 India Japanese encephalitis 1 317 293 2017 dengue outbreak in Sri Lanka 2017 Sri Lanka Dengue fever 440 294 2018 Nipah virus outbreak in Kerala 2018 India Nipah virus infection 17 295 Kivu Ebola epidemic 2018 2020 Democratic Republic of the Congo and Uganda Ebola 2 280 296 297 298 2018 NDM CRE outbreak in Italy 2018 2019 Italy New Delhi metallo beta lactamase producing Carbapenem resistant enterobacteriaceae 31 as of September 2019 299 2019 2020 measles outbreak in the Democratic Republic of the Congo 2019 2020 Democratic Republic of the Congo Measles 7 018 300 2019 2020 New Zealand measles outbreak 2019 2020 New Zealand Measles 2 301 2019 measles outbreak in the Philippines 2019 Philippines Measles 415 302 2019 Kuala Koh measles outbreak 2019 Kuala Koh Malaysia Measles 15 303 2019 Samoa measles outbreak 2019 Samoa Measles 83 304 2019 2020 dengue fever epidemic 2019 2020 Asia Pacific Latin America Dengue fever 3 931 305 COVID 19 pandemic 2019 e present Worldwide COVID 19 nbsp SARS CoV 2 virus 7 36 6 million 307 308 309 310 2020 Democratic Republic of the Congo Ebola outbreak 2020 Democratic Republic of the Congo Ebola 55 311 2020 dengue outbreak in Singapore 2020 Singapore Dengue fever 32 312 2020 Nigeria yellow fever epidemic 2020 Nigeria Yellow fever 296 as of 31 December 2020 313 2021 India black fungus epidemic 2021 2022 India Black fungus COVID 19 condition 4 332 314 2022 hepatitis of unknown origin in children 2021 2022 Worldwide Hepatitis by Adenovirus variant AF41 Unconfirmed 18 315 316 317 2022 2023 mpox outbreak 2022 2023 Worldwide Monkeypox virus 280 318 319 320 321 2022 Uganda Ebola outbreak 2022 2023 Uganda Sudan ebolavirus 77 322 2023 South Poland Legionellosis outbreak 2023 Poland Legionella 23 323 324 See also nbsp Pandemic portalGlobalization and disease Overview of globalization and disease transmission History of smallpox Impact of smallpox on world history List of Ebola outbreaks Cases and outbreaks of Ebola virus disease List of infectious diseases List of natural disasters by death toll Deadliest epidemics Timeline of plague Human and animal diseasePages displaying short descriptions of redirect targetsExplanatory notes a b c d The estimates of global population at the time vary non trivially no consensus The current estimates are based on the available population data from estimates of historical world population and the sources in these footnotes 3 4 a b Global population changed significantly not due to the epidemic during the period of this epidemic Epidemic 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