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London flu

March 10, 2023

During the 1972–1973 flu season in the Northern Hemisphere, a new variant of influenza, dubbed the 'London flu' by the press in the United States, was responsible for epidemics in many countries. 'London flu' was caused by a variant of influenza A/H3N2 that was first isolated in India in mid-1971 but only identified as a distinct strain in England in January, 1972.[1]

History

Background

In July 1968, a novel subtype of influenza A, H3N2, caused a massive epidemic in Hong Kong and subsequently spread to other countries, leading to the global Hong Kong flu pandemic that lasted until 1970. Through April 1972, little antigenic difference from the original Hong Kong virus was noted on the whole among circulating strains.[2] In July 1971, "a fairly extensive outbreak" occurred in Coonoor, India, though it did not immediately spread to other countries. Although the virus was originally isolated in India, it was not identified by the World Health Organization as a "drift" variant until January 1972, when a single strain, ultimately classified as A/England/42/72, was isolated among over 700 others collected during an epidemic in England.[1] It was not until May 1972, however, as the winter flu season began in the Southern Hemisphere, that it resulted in outbreaks in Malaysia, Singapore, and Australia.[3]

In the 1971–1972 flu season, influenza activity in the United States was reported in 49 of the 50 states and became widespread in 21. Pneumonia and influenza excess mortality remained above the epidemic threshold for seven consecutive weeks[4] and ultimately was the highest since the initial introduction of the pandemic virus into the country in the 1968–1969 season.[5] Despite the identification of the novel variant in January, the Center for Disease Control (today the Centers for Disease Control and Prevention) in June announced that the influenza A strain to be used in the vaccines for the 1972–1973 season would remain the same, albeit its potency increased.[6] Although it was recognized that the variant could spread globally similar to the original virus,[7] experts did not anticipate a serious epidemic after the widespread outbreak the year before.[8] (The England variant was also not the only one to have emerged and caused outbreaks in the past year, and it was not until the middle of 1972 that it really took off.)[1] In October, the CDC warned of the likely appearance of "new strains" of influenza A in the upcoming flu season.[9]

Progression within the United States

Similar to the introduction of the original pandemic virus into the country in 1968, the first cases of the new variant appeared among military personnel. On 21 October, just a couple of weeks after the CDC's warning, an outbreak began at the Air Force Academy in Colorado Springs, lasting into early November. A total of 870 were reported sick.[10] During the first week of November, another outbreak developed at Lowry Air Force Base, east of Denver. Doctors reported seeing 35 new cases per day for at least 10 days.[11] The Colorado Department of Health identified the variant as the cause of the outbreak,[11] and this was for a time considered the first to occur in the continental US,[12] though strains from the Academy outbreak were soon found to be highly related to those from the Base.[13] In late November and early December, outbreaks were reported at two other military installations, one in Arizona and another near Colorado Springs.[14]

The first major civilian outbreak developed in Baltimore the last week of November. Isolated cases and outbreaks were reported around the same time and into the weeks of December.[10] On 12 December, the CDC reported cases in five cities: Memphis; Kansas City, Kansas; Baltimore; Anchorage; and Seattle.[15] By 23 December, influenza had been documented in 14 states, and significant outbreaks were occurring in New York City, Baltimore, and the San Francisco Bay Area.[10]

By 13 January 1973, 18 states had documented cases of influenza, with only sporadic cases occurring elsewhere. Activity peaked in the mid-Atlantic and Pacific areas in early January, with a subsequent rise in excess mortality above the epidemic threshold for two or more weeks in mid-January.[10] California was evidently the hardest-hit state by this point, with mortality approaching the epidemic threshold in the 11 largest cities of northern California.[4]

The epidemic reportedly aggravated an ongoing shortage of blood at this time in places such as Baltimore and New York City.[16][17]

As activity in the northeast declined in the second half of January, cases began to rise in the Southeastern United States and the Midwestern United States, peaking in the middle of February.[10] On 2 February, the CDC reported that the country had surpassed 1,000 deaths from influenza and pneumonia;[18] by 9 February, the figure had risen to over 4,300 deaths since the beginning of the year.[19]

The epidemic had begun to wane by the first week of March, with excess mortality declining throughout February and falling below the epidemic threshold for the first time by 9 March. In total, excess mortality from pneumonia and influenza was the highest since the 1968–1969 flu season and the initial introduction of the pandemic virus into the US.[10] California alone reported at least 1,083 deaths in its major cities.[20] The National Center for Health Statistics attributed 18,300 all-cause excess deaths to this flu season, though subsequent studies identified at least 21,400 and as many as 29,200 all-cause excess deaths.[21]

International reports

The World Health Organization reported outbreaks also in the Soviet Union, the Netherlands, Switzerland, Morocco and Lebanon, with localized outbreaks in four other countries.[18]

Analysis

Subsequent statistical analysis indicated that by the following season (1973–1974), influenza type B was predominating over type A strains by a factor approaching 4:1.[22]

References

  1. ^ a b c Cockburn, W. C. (2 June 1973). "Influenza — The World Problem". Medical Journal of Australia. 1 (SP1): 8. doi:10.5694/j.1326-5377.1973.tb111167.x. PMID 4717620.
  2. ^ World Health Organization (1972). "INFLUENZA IN THE WORLD: OCTOBER 1971 - SEPTEMBER 1972*". Weekly Epidemiological Record. 47: 430. hdl:10665/219147 – via IRIS.
  3. ^ World Health Organization (1972). "ANTIGENIC VARIATION IN INFLUENZA A VIRUSES". Weekly Epidemiological Record. 47: 381. hdl:10665/219102 – via IRIS.
  4. ^ a b FLU NOW EXCEEDS EPIDEMIC LEVEL 13 January 1973, www.nytimes.com, accessed 13 February 2020
  5. ^ Center for Disease Control (January 1973). "Influenza-respiratory disease surveillance report no. 88, January, 1973". Influenza Surveillance Reports: 5 – via CDC.
  6. ^ Center for Disease Control (17 June 1972). "Morbidity and mortality weekly report, Vol. 21, no. 24, For week ending June 17, 1972". Morbidity and Mortality Weekly Report. 21: 207 – via CDC.
  7. ^ Sousa, V. O.; Graves, I. L.; Pyakural, S. (1974). "Spread of influenzaviruses A/England/42/72 and A/Hong Kong/1/68". Bulletin of the World Health Organization. 50 (6): 477. hdl:10665/263788. PMC 2481177. PMID 4549196.
  8. ^ Influenza Outbreak In ‘Critical’ Period For Impact on U.S. 22 December 1972, www.nytimes.com, accessed 13 February 2020
  9. ^ "NEW STRAINS OF FLU EXPECTED IN WINTER". The New York Times. 7 October 1972. p. 40. Retrieved 9 May 2022.
  10. ^ a b c d e f Center for Disease Control (February 1974). "Influenza-respiratory disease surveillance report no. 89, 1972-1973". Influenza Surveillance Report: 6 – via CDC.
  11. ^ a b "New Flu Strain Turns Up At Air Base in Colorado". The New York Times. 18 November 1972. p. 19. Retrieved 10 May 2022.
  12. ^ "Morbidity and mortality weekly report, Vol. 21, no. 45, For week ending November 11, 1972". Morbidity and Mortality Weekly Report. 21: 387. 11 November 1972 – via CDC.
  13. ^ "Morbidity and mortality weekly report, Vol. 21, no. 48, For week ending December 2, 1972". Morbidity and Mortality Weekly Report. 21: 410. 2 December 1972 – via CDC.
  14. ^ Center for Disease Control (February 1974). "Influenza-respiratory disease surveillance report no. 89, 1972-1973". Influenza Surveillance Report: 6 – via CDC.
  15. ^ "FLU CASES REPORTED IN 5 BIG U.S. CITIES". The New York Times. 13 December 1972. p. 45. Retrieved 10 May 2022.
  16. ^ Altman, Lawrence K. (1 January 1973). "BLOOD SHORTAGE DELAYS SURGERY IN MAJOR CITIES". The New York Times. p. 1. Retrieved 10 May 2022.
  17. ^ "Metropolitan Briefs". The New York Times. 3 January 1973. p. 43. Retrieved 10 May 2022.
  18. ^ a b London-Flu Deaths Exceed 1,000 Mark 3 February 1973 Desert Sun via cdnc.ucr.edu, accessed 13 February 2020
  19. ^ "Flu and Pneumonia Deaths Continue to Rise in Nation". The New York Times. 10 February 1973. p. 37. Retrieved 10 May 2022.
  20. ^ "Flu Epidemic Over". The Desert Sun. 16 March 1973. pp. A2. Retrieved 10 May 2022.
  21. ^ Simonsen, L.; Clarke, M. J.; Williamson, G. D.; Stroup, D. F.; Arden, N. H.; Schonberger, L. B. (December 1997). "The impact of influenza epidemics on mortality: introducing a severity index". American Journal of Public Health. 87 (12): 1947. doi:10.2105/ajph.87.12.1944. PMC 1381234. PMID 9431281.
  22. ^ Influenza surveillance report no. 90, 1973-1974 and 1974-1975 February 1976 stacks.cdc.gov/view/cdc/286, accessed 13 February 2020

March 10, 2023
london, during, 1972, 1973, season, northern, hemisphere, variant, influenza, dubbed, press, united, states, responsible, epidemics, many, countries, caused, variant, influenza, h3n2, that, first, isolated, india, 1971, only, identified, distinct, strain, engl. During the 1972 1973 flu season in the Northern Hemisphere a new variant of influenza dubbed the London flu by the press in the United States was responsible for epidemics in many countries London flu was caused by a variant of influenza A H3N2 that was first isolated in India in mid 1971 but only identified as a distinct strain in England in January 1972 1 Contents 1 History 1 1 Background 1 2 Progression within the United States 1 3 International reports 2 Analysis 3 ReferencesHistory EditBackground Edit In July 1968 a novel subtype of influenza A H3N2 caused a massive epidemic in Hong Kong and subsequently spread to other countries leading to the global Hong Kong flu pandemic that lasted until 1970 Through April 1972 little antigenic difference from the original Hong Kong virus was noted on the whole among circulating strains 2 In July 1971 a fairly extensive outbreak occurred in Coonoor India though it did not immediately spread to other countries Although the virus was originally isolated in India it was not identified by the World Health Organization as a drift variant until January 1972 when a single strain ultimately classified as A England 42 72 was isolated among over 700 others collected during an epidemic in England 1 It was not until May 1972 however as the winter flu season began in the Southern Hemisphere that it resulted in outbreaks in Malaysia Singapore and Australia 3 In the 1971 1972 flu season influenza activity in the United States was reported in 49 of the 50 states and became widespread in 21 Pneumonia and influenza excess mortality remained above the epidemic threshold for seven consecutive weeks 4 and ultimately was the highest since the initial introduction of the pandemic virus into the country in the 1968 1969 season 5 Despite the identification of the novel variant in January the Center for Disease Control today the Centers for Disease Control and Prevention in June announced that the influenza A strain to be used in the vaccines for the 1972 1973 season would remain the same albeit its potency increased 6 Although it was recognized that the variant could spread globally similar to the original virus 7 experts did not anticipate a serious epidemic after the widespread outbreak the year before 8 The England variant was also not the only one to have emerged and caused outbreaks in the past year and it was not until the middle of 1972 that it really took off 1 In October the CDC warned of the likely appearance of new strains of influenza A in the upcoming flu season 9 Progression within the United States Edit Similar to the introduction of the original pandemic virus into the country in 1968 the first cases of the new variant appeared among military personnel On 21 October just a couple of weeks after the CDC s warning an outbreak began at the Air Force Academy in Colorado Springs lasting into early November A total of 870 were reported sick 10 During the first week of November another outbreak developed at Lowry Air Force Base east of Denver Doctors reported seeing 35 new cases per day for at least 10 days 11 The Colorado Department of Health identified the variant as the cause of the outbreak 11 and this was for a time considered the first to occur in the continental US 12 though strains from the Academy outbreak were soon found to be highly related to those from the Base 13 In late November and early December outbreaks were reported at two other military installations one in Arizona and another near Colorado Springs 14 The first major civilian outbreak developed in Baltimore the last week of November Isolated cases and outbreaks were reported around the same time and into the weeks of December 10 On 12 December the CDC reported cases in five cities Memphis Kansas City Kansas Baltimore Anchorage and Seattle 15 By 23 December influenza had been documented in 14 states and significant outbreaks were occurring in New York City Baltimore and the San Francisco Bay Area 10 By 13 January 1973 18 states had documented cases of influenza with only sporadic cases occurring elsewhere Activity peaked in the mid Atlantic and Pacific areas in early January with a subsequent rise in excess mortality above the epidemic threshold for two or more weeks in mid January 10 California was evidently the hardest hit state by this point with mortality approaching the epidemic threshold in the 11 largest cities of northern California 4 The epidemic reportedly aggravated an ongoing shortage of blood at this time in places such as Baltimore and New York City 16 17 As activity in the northeast declined in the second half of January cases began to rise in the Southeastern United States and the Midwestern United States peaking in the middle of February 10 On 2 February the CDC reported that the country had surpassed 1 000 deaths from influenza and pneumonia 18 by 9 February the figure had risen to over 4 300 deaths since the beginning of the year 19 The epidemic had begun to wane by the first week of March with excess mortality declining throughout February and falling below the epidemic threshold for the first time by 9 March In total excess mortality from pneumonia and influenza was the highest since the 1968 1969 flu season and the initial introduction of the pandemic virus into the US 10 California alone reported at least 1 083 deaths in its major cities 20 The National Center for Health Statistics attributed 18 300 all cause excess deaths to this flu season though subsequent studies identified at least 21 400 and as many as 29 200 all cause excess deaths 21 International reports Edit The World Health Organization reported outbreaks also in the Soviet Union the Netherlands Switzerland Morocco and Lebanon with localized outbreaks in four other countries 18 Analysis EditSubsequent statistical analysis indicated that by the following season 1973 1974 influenza type B was predominating over type A strains by a factor approaching 4 1 22 References Edit a b c Cockburn W C 2 June 1973 Influenza The World Problem Medical Journal of Australia 1 SP1 8 doi 10 5694 j 1326 5377 1973 tb111167 x PMID 4717620 World Health Organization 1972 INFLUENZA IN THE WORLD OCTOBER 1971 SEPTEMBER 1972 Weekly Epidemiological Record 47 430 hdl 10665 219147 via IRIS World Health Organization 1972 ANTIGENIC VARIATION IN INFLUENZA A VIRUSES Weekly Epidemiological Record 47 381 hdl 10665 219102 via IRIS a b FLU NOW EXCEEDS EPIDEMIC LEVEL 13 January 1973 www nytimes com accessed 13 February 2020 Center for Disease Control January 1973 Influenza respiratory disease surveillance report no 88 January 1973 Influenza Surveillance Reports 5 via CDC Center for Disease Control 17 June 1972 Morbidity and mortality weekly report Vol 21 no 24 For week ending June 17 1972 Morbidity and Mortality Weekly Report 21 207 via CDC Sousa V O Graves I L Pyakural S 1974 Spread of influenzaviruses A England 42 72 and A Hong Kong 1 68 Bulletin of the World Health Organization 50 6 477 hdl 10665 263788 PMC 2481177 PMID 4549196 Influenza Outbreak In Critical Period For Impact on U S 22 December 1972 www nytimes com accessed 13 February 2020 NEW STRAINS OF FLU EXPECTED IN WINTER The New York Times 7 October 1972 p 40 Retrieved 9 May 2022 a b c d e f Center for Disease Control February 1974 Influenza respiratory disease surveillance report no 89 1972 1973 Influenza Surveillance Report 6 via CDC a b New Flu Strain Turns Up At Air Base in Colorado The New York Times 18 November 1972 p 19 Retrieved 10 May 2022 Morbidity and mortality weekly report Vol 21 no 45 For week ending November 11 1972 Morbidity and Mortality Weekly Report 21 387 11 November 1972 via CDC Morbidity and mortality weekly report Vol 21 no 48 For week ending December 2 1972 Morbidity and Mortality Weekly Report 21 410 2 December 1972 via CDC Center for Disease Control February 1974 Influenza respiratory disease surveillance report no 89 1972 1973 Influenza Surveillance Report 6 via CDC FLU CASES REPORTED IN 5 BIG U S CITIES The New York Times 13 December 1972 p 45 Retrieved 10 May 2022 Altman Lawrence K 1 January 1973 BLOOD SHORTAGE DELAYS SURGERY IN MAJOR CITIES The New York Times p 1 Retrieved 10 May 2022 Metropolitan Briefs The New York Times 3 January 1973 p 43 Retrieved 10 May 2022 a b London Flu Deaths Exceed 1 000 Mark 3 February 1973 Desert Sun via cdnc ucr edu accessed 13 February 2020 Flu and Pneumonia Deaths Continue to Rise in Nation The New York Times 10 February 1973 p 37 Retrieved 10 May 2022 Flu Epidemic Over The Desert Sun 16 March 1973 pp A2 Retrieved 10 May 2022 Simonsen L Clarke M J Williamson G D Stroup D F Arden N H Schonberger L B December 1997 The impact of influenza epidemics on mortality introducing a severity index American Journal of Public Health 87 12 1947 doi 10 2105 ajph 87 12 1944 PMC 1381234 PMID 9431281 Influenza surveillance report no 90 1973 1974 and 1974 1975 February 1976 stacks cdc gov view cdc 286 accessed 13 February 2020 Retrieved from https en wikipedia org w index php title London flu amp oldid 1113057984, wikipedia, wiki, book, books, library,

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