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Kivu Ebola epidemic

December 21, 2023

This article is about an Ebola virus outbreak in the Democratic Republic of the Congo and Uganda. For the prior Ebola outbreak in DRC, see 2018 Équateur province Ebola outbreak.

The Kivu Ebola epidemic[note 2] was an outbreak of Ebola virus disease (EVD) mainly in eastern Democratic Republic of the Congo (DRC), and in other parts of Central Africa, from 2018 to 2020.[10] Between 1 August 2018 and 25 June 2020 it resulted in 3,470 reported cases.[11] The Kivu outbreak also affected Ituri Province, whose first case was confirmed on 13 August 2018.[9] In November 2018, the outbreak became the biggest Ebola outbreak in the DRC's history,[12][13][14] and had become the second-largest Ebola outbreak in recorded history worldwide,[11][15] behind only the 2013–2016 Western Africa epidemic.[11][16] In June 2019, the virus reached Uganda, having infected a 5-year-old Congolese boy who entered Uganda with his family,[17] but was contained.[11]

Kivu Ebola epidemic
Democratic Republic of the Congo & Uganda; areas affected by the epidemic.
Date1 August 2018 (2018-08-01) – 25 June 2020 (2020-06-25)[1]
Casualties
Country Cases (conf./prob./susp.) Deaths Last update
DRC 3,313 / 153 / 0 2,266[1][2]
Uganda 4 / 0 / 0 4[3][4][5][6][7]
Total 3,470
[note 1]		 2,280
[note 1]		 As of 25 June 2020

A military conflict in the region that had begun in January 2015 hindered treatment and prevention efforts. The World Health Organization (WHO) described the combination of military conflict and civilian distress as a potential "perfect storm" that could lead to a rapid worsening of the outbreak.[18][19] In May 2019, the WHO reported that since January, 85 health workers had been wounded or killed in 42 attacks on health facilities. In some areas, aid organizations had to stop their work due to violence.[20] Health workers also had to deal with misinformation spread by opposing politicians.[21]

Due to the deteriorating security situation in North Kivu and surrounding areas, the WHO raised the risk assessment at the national and regional level from "high" to "very high" in September 2018.[22] In October, the United Nations Security Council stressed that all armed hostility in the DRC should come to a stop to better fight the ongoing EVD outbreak.[23][24][25] A confirmed case in Goma triggered the decision by the WHO to convene an emergency committee for the fourth time,[26][27] and on 17 July 2019, the WHO announced a Public Health Emergency of International Concern (PHEIC), the highest level of alarm the WHO can sound.[28]

On 15 September 2019, some slowdown of EVD cases was noted by the WHO in DRC.[29] However, contact tracing continued to be less than 100%; at the time, it was at 89%.[29] As of mid-October the transmission of the virus had significantly reduced; by then it was confined to the Mandima region near where the outbreak began, and was only affecting 27 health zones in the DRC (down from a peak of 207).[30] New cases dwindled to zero by 17 February 2020,[31] but after 52 days without a case, surveillance and response teams on the ground confirmed three new cases of Ebola in Beni health zone in mid-April.[32][33][34] On 25 June 2020, the outbreak was declared ended.[1][16]

As a new and separate outbreak, the Congolese health ministry reported on 1 June 2020 that there were cases of Ebola in Équateur Province in north-western DRC, described as the eleventh Ebola outbreak since records began.[35] This separate outbreak was declared over as of 18 November following no reported cases for 42 days,[36] and caused 130 cases and 55 deaths.[37]

Epidemiology edit

As indicated below and per numbers offered by the United Nations the final death toll was 2,280 with a total of 3,470 cases in DRC in almost a two-year period. This was made very difficult due to the ongoing military attacks in the region which created a perfect storm for the virus, despite there being a vaccine.[38] rVSV-ZEBOV or Ebola Zaire vaccine live, is a vaccine that prevents Ebola caused by the Zaire ebolavirus.[39] The graph of reported cases reflects cases that were not able to have a laboratory test sample before burial as probable cases.[40]

 
Note Above graph begins in Aug. 2018 at one month intervals, then progresses to two month intervals as the outbreak intensifies at beginning of 2019, then finally has a four month interval until it is declared over (due to a flare up just days prior to the first two 21 day period to call the outbreak over per WHO, which caused a restart of the coutdown)
*2018–19 Kivu Ebola epidemic (total cases-deaths as of 25 June 2020)[1]
*x indicates (2) 21 day periods have passed and outbreak is over

Democratic Republic of the Congo edit

 
Map of the Democratic Republic of the Congo; North Kivu (orange, middle) South Kivu (dark red, bottom) and Ituri (green, top)

On 1 August 2018, the North Kivu health division notified Congo's health ministry of 26 cases of hemorrhagic fever, including 20 deaths. Four of the six samples that were sent for analysis to the National Institute of Biological Research in Kinshasa came back positive for Ebola and an outbreak was declared on that date.[41][42] The index case is believed to have been the death and unsafe burial of a 65-year-old woman on 25 July in Mangina, quickly followed by the deaths of seven close family members.[43] This outbreak started just days after the end of the outbreak in Équateur province.[44][45] On 1 August, just after the Ebola epidemic had been declared, Doctors Without Borders/Médecins Sans Frontières (MSF) arrived in Mangina, the point of origin of the outbreak, to mount a response.[46] On 2 August, Oxfam indicated it would be taking part in the response to this latest outbreak in the DRC.[47] On 4 August, the WHO indicated that the current situation in the DRC, due to several factors, warranted a "high risk assessment" at the national and regional level for public health.[48]

By 3 August, the virus had developed in multiple locations; cases were reported in five health zones – Beni, Butembo, Oicha, Musienene and Mabalako – in North Kivu province as well as Mandima and Mambasa in Ituri Province.[49] However, one month later there had been confirmed cases only in the Mabalako, Mandima, Beni and Oicha health zones. The five suspected cases in the Mambasa Health Zone proved not to be EVD; it was not possible to confirm the one probable case in the Musienene Health Zone and the two probable cases in the Butembo Health Zone. No new cases had been recorded in any of those health zones.[50]

WHO chief Tedros Adhanom Ghebreyesu indicated on 15 August that the outbreak then in the DRC might be worse than the West African outbreak of 2013–2016,[51] with the IRC connecting this to the ongoing Kivu conflict.[52] The Kivu outbreak was the biggest of the ten recorded outbreaks recorded in the DRC.[53] The first confirmed case in Butembo was announced on 4 September, the same day that it was announced that one of the cases registered at Beni had actually come from the Kalunguta Health Zone.[50]

In November, it was reported that the EVD outbreak ran across two provinces and 14 health zones.[40] By 23 December, the EVD outbreak had spread to more health zones, and at that time 18 such areas had been affected.[54]

Becoming the 2nd biggest EVD outbreak edit

On 7 August 2018, the DRC Ministry of Public Health indicated that the total count had climbed to almost 90 cases,[55] and the Uganda Ministry of Health issued an alert for extra surveillance as the outbreak was just 100 kilometres (62 mi) away from its border.[56] Two days later the total count was nearly 100 cases.[57] On 16 August, the United Kingdom indicated it would help with EVD diagnosis and monitoring in the DRC.[58] On 17 August 2018, the WHO reported that there were around 1,500 "contacts", while noting that certain conflict zones in the DRC that could not be reached might have contained more contacts.[59] Some 954 contacts were successfully followed up on 18 August; however, Mandima Health Zone indicated resistance, so contacts were not followed up there.[60] On 4 September, Butembo, a city with almost one million people and an international airport, recorded its first fatality in the Ebola outbreak. The city of Butembo, in the DRC, has trade links to nearby Uganda.[61][50]

On 24 September, it was reported that all contact tracing and vaccinations would stop for the foreseeable future in Beni due to a deadly attack by rebel groups the day before.[62] On 25 September, Peter Salama of the WHO indicated that insecurity was obstructing efforts to stop the virus and believed a combination of factors could establish conditions for an epidemic.[63] On 18 October, the U.S. Centers for Disease Control and Prevention (CDC) raised its travelers' alert to the DRC from a level 1 to level 2 for all U.S. travelers.[64] On 26 October, the WHO indicated that half of confirmed cases were not showing any fever symptoms, thus making diagnosis more difficult.[65]

According to a September 2018 Lancet survey, 25% of respondents in Beni and Butembo believed the Ebola outbreak to be a hoax. These beliefs correlated with decreased likelihood of seeking healthcare or accepting vaccination.[66]

On 6 November 2018, the CDC indicated that the current outbreak in the east region of the DRC was potentially non-containable. This would be the first time since 1976 that an outbreak was not able to be curbed.[67] On 13 November, the WHO indicated that the viral outbreak would last at least six months.[68]

On 29 December 2018, the DRC Ministry of Public Health announced that there had been "0 new confirmed cases detected because of the paralysis of the activities of the response in Beni, Butembo, Komanda and Mabalako" and no vaccination had occurred for three consecutive days.[69] On 22 January, the total case count approached 1,000 cases, (951 suspected) in the DRC Ministry of Public Health situation report.[70] The graphs below demonstrate the EVD intensity in different locations in the DRC, as well as in the West African epidemic of 2014–15 as a comparison:

  •  
    Mabalako between 16 July and 31 December 2018[71]
  •  
    Beni between 23 July 2018 and 28 January 2019[72]
  •  
    Katwa (orange) and Butembo (purple) between 23 July 2018 and 4 February 2019[73]
  •  
    Western Africa Ebola Epidemic (for comparison with current outbreak).[74]

On 16 March 2019, the director of the CDC indicated that the outbreak in the DRC could last another year, additionally suggesting that vaccine supplies could run out.[75] According to the WHO, resistance to vaccination in the Kaniyi Health Zone was ongoing as of March 2019.[76] There was still a belief by some in surrounding areas that the epidemic was a hoax.[77]

 
Democratic Republic of the Congo EVD outbreaks 1976-9 November 2018
(Note: total cases for this date does not reflect 52 suspected cases nor does it reflect the final case numbers)[12][78]
(Uganda has second most EVD cases '00–'01/425[79]
West African Ebola virus epidemic '13-'16/ >28,000[80])

Until the outbreak in North Kivu in 2018, no outbreak had surpassed 320 total cases in the Democratic Republic of the Congo. By 24 February 2019, the epidemic had surpassed 1,000 total cases (1,048).[81][82]

On 10 May 2019, the U.S. Centers for Disease Control and Prevention indicated that the outbreak could eventually surpass the West African epidemic.[83]

The 12 May 2019 issue of WHO Weekly Bulletin on Outbreaks and Other Emergencies, indicates that "continued increase in the number of new EVD cases in the Democratic Republic of the Congo is worrying...no end in sight to the difficult security situation".[84] On 25 November 2019, it was reported that violence had broken out in Beni again, to such a degree that some aid agencies had evacuated. According to the same report, around 300 individuals might have been exposed to EVD via an infected individual.[85]

Spread to Goma edit

On 14 July 2019, the first case of EVD was confirmed in the capital of North Kivu, Goma, a city with an international airport and a highly mobile population of 2 million people located near the DRC's eastern border with Rwanda.[86][87][88][89] This case was a man who had passed through three health checkpoints, with different names on traveller lists.[27] The WHO stated that he died in a treatment centre,[90] whereas according to Reuters he died en route to a treatment centre.[91] This case triggered the decision by the WHO to again reconvene an emergency committee,[26][27] where the situation was officially declared a Public Health Emergency of International Concern.[28]

On 30 July, a second case of EVD was confirmed in the city of Goma, apparently not linked to the first case.[92] Across the border from Goma in the country of Rwanda, Ebola simulation drills were being conducted at health facilities.[93] A third case of EVD was confirmed in Goma on 1 August.[94] On 22 August 2019, Nyiragongo Health Zone, the affected area on the outskirts of Goma, reached 21 days without further cases being confirmed.[95]

Spread to South Kivu Province edit

On 16 August 2019, it was reported that the Ebola virus disease had spread to a third province – South Kivu – via two new cases who had travelled from Beni, North Kivu.[96][97] By 22 August the number of cases in Mwenga had risen to four, including one person at a health facility visited by the first case.[98]

Uganda edit

Further information: Refugees of Uganda
 
Map of Uganda; District Kasese in Western Region

In August 2018 a UN agency indicated that active screening was deployed to ensure that those leaving the DRC into Uganda were not infected with Ebola.[99] The government of Uganda opened two Ebola treatment centers at the border with the DRC, though there had not yet been any confirmed cases in the country of Uganda.[100][101] By 13 June 2019, nine treatment units were in place near the affected border.[102]

According to the International Red Cross, a "most likely scenario" entailed an asymptomatic case entering the country of Uganda undetected among the numerous refugees then coming from the DRC.[103] On 20 September, Uganda indicated it was ready for immediate vaccination, should the Ebola virus be detected in any individual.[104][105]

On 21 September, officials of the DRC indicated a confirmed case of EVD at Lake Albert, an entry point into Uganda, though no cases were then confirmed within Ugandan territory.[106][107]

On 2 November, it was reported that the Ugandan government would start vaccinating health workers along the border with the DRC as a proactive measure against the virus.[108] Vaccinations started on 7 November, and by 13 June 2019, 4,699 health workers at 165 sites had been vaccinated.[102] Proactive vaccination was also carried out in South Sudan, with 1,471 health workers vaccinated by 7 May 2019.[109]

On 2 January 2019, it was reported that refugee movement from the DRC to Uganda had increased after the presidential elections.[110] On 12 February, it was reported that 13 individuals had been isolated due to their contact with a suspected Ebola case in Uganda;[111] lab results came back negative several hours later.[112]

On 11 June 2019, the WHO reported that the virus had spread to Uganda. A 5-year-old Congolese boy entered Uganda on the previous Sunday with his family to seek medical care. On 12 June, the WHO reported that the 5-year-old patient had died, while 2 more cases of Ebola infection within the same family were also confirmed.[17][113] On 14 June it was reported that there were 112 contacts since EVD was first detected in Uganda.[114] Ring vaccination of Ugandan contacts was scheduled to start on 15 June.[25] As of 18 June 2019, 275 contacts had been vaccinated per the Uganda Ministry of Health.[115]

On 14 July, an individual entered the country of Uganda from DRC while symptomatic for EVD; a search for contacts in Mpondwe followed.[116] On 24 July, Uganda marked the needed 42 day period without any EVD cases to be declared Ebola-free.[117] On 29 August, a 9-year-old Congolese girl became the fourth individual in Uganda to test positive for EVD when she crossed from the DRC into the district of Kasese.[118]

Tanzania edit

 
Map of United Republic of Tanzania

In regards to possible EVD cases in Tanzania, the WHO stated on 21 September 2019 that "to date, the clinical details and the results of the investigation, including laboratory tests performed for differential diagnosis of these patients, have not been shared with WHO. The insufficient information received by WHO does not allow for a formulation of a hypotheses regarding the possible cause of the illness".[119][120][121] On 27 September, the CDC and U.S. State Department alerted potential travellers to the possibility of unreported EVD cases within Tanzania.[122]

The Tanzanian Health Minister Ummy Mwalimu stated on 3 October 2019 that there was no Ebola outbreak in Tanzania.[123] The WHO were provided with a preparedness update on 18 October which outlined a range of actions, and included commentary that since the outbreak commenced, there had been "29 alerts of Ebola suspect cases reported, 17 samples tested and were negative for Ebola (including 2 in September 2019)".[124]

Countries with medically evacuated individuals edit

On 29 December, an American physician who was exposed to the Ebola virus (and who was non-symptomatic) was evacuated, and taken to the University of Nebraska Medical Center.[125][126] On 12 January, the individual was released after 21 days without symptoms.[127]

The table which follows indicates confirmed, probable and suspected cases, as well as deaths; the table also indicates the multiple countries where these cases took place, during this outbreak.

Table 1. Timeline of reported cases[78]
Date Cases # Deaths CFR Contacts Sources
Confirmed Probable Suspected Totals
DRC.2018-08-01†DRC 4 22 0 26 20 - - [128]
2018-08-03 13 30 33 76 33 0.76.7%‡ 879 [129][130]
2018-08-05 16 27 31 74 34 79%‡ 966 [131][132]
2018-08-10 25 27 48 100 39 75%‡ 953 [133]
2018-08-12 30 27 58 115 41 - 997 [134]
2018-08-17 64 27 12 103 50 0.55.6%‡ 1,609 [60]
2018-08-20 75 27 9 111 59 - 2,408 [135]
2018-08-24 83 28 6 117 72 65%‡ 3,421 [136]
2018-08-26 83 28 10 121 75 0.67.6%‡ 2,445 [137]
2018-08-31 90 30 8 128 78 65%‡ 2,462 [138]
2018-09-02 91 31 9 131 82 - 2,512 [139]
2018-09-07 100 31 14 145 89 68%‡ 2,426 [140]
2018-09-09 101 31 9 141 91 - 2,265 [141][142]
2018-09-14 106 31 17 154 92 0.67.2%‡ 1,751 [143]
2018-09-16 111 31 7 149 97 - 2,173 [144][145]
2018-09-21 116 31 n/a 147 99 0.67.3%‡ 1,641 [146]
2018-09-23 119 31 9 159 100 67%‡ 1,836 [147]
2018-09-28 126 31 23 180 102 65%‡ 1,410 [148]
2018-10-02 130 32 17 179 106 0.65.4%‡ 1,463 [149]
2018-10-05 142 35 11 188 113 0.63.8%‡ 2,045 [150]
2018-10-07 146 35 21 202 115 0.63.5%‡ 2,115 [151]
2018-10-12 176 35 32 243 135 64%‡ 2,663 [152]
2018-10-15 181 35 32 248 139 64%‡ 4,707 [153]
2018-10-19 202 35 33 270 153 65%‡ 5,518 [154]
2018-10-21 203 35 14 252 155 65%‡ 5,341 [155]
2018-10-26 232 35 43 310 170 64%‡ 6,026 [65]
2018-10-28 239 35 32 306 174 0.63.5%‡ 5,991 [156]
2018-11-02 263 35 70 368 186 0.62.4%‡ 5,036 [157]
2018-11-04 265 35 61 361 186 62%‡ 4,971 [158]
2018-11-09 294 35 60 389 205 62%‡ 4,779 [159]
2018-11-11 295 38 n/a 333 209 - 4,803 [160]
2018-11-16 319 47 49 415 214 59%‡ 4,430 [161]
2018-11-21 326 47 90 463 217 - 4,668 [162]
2018-11-23 365 47 45 457 236 57%‡ 4,354 [163]
2018-11-26 374 47 74 495 241 57%‡ 4,767 [164]
2018-11-30 392 48 63 503 255 58%‡ 4,820 [165]
2018-12-03 405 48 79 532 268 59%‡ 5,335 [166]
2018-12-07 446 48 95 589 283 57%‡ 6,417 [167]
2018-12-10 452 48 n/a 500 289 58%‡ 6,509 [168]
2018-12-14 483 48 111 642 313 59%‡ 6,695 [169]
2018-12-21 526 48 118 692 347 60%‡ 8,422 [170]
2018-12-28 548 48 52 648 361 61%‡ 7,007 [171]
2019-01-04 575 48 118 741 374 60%‡ 5,047 [172]
2019-01-11 595 49 n/a 644 390 61%‡ 4,937 [173]
2019-01-18 636 49 209 894 416 61%‡ 4,971 [174][175]
2019-01-25 679 54 204 937 459 63%‡ 6,241 [176][177]
2019-02-01 720 54 168 942 481 62%‡ >7,000 [178][179]
2019-02-10 750 61 148 959 510 63%‡ 7,846 [180][181]
2019-02-18 773 65 135 973 534 64%‡ 6,772 [182][183]
2019-02-24 804 65 219 1,088 546 63%‡ 5,739 [184][185]
2019-03-03 830 65 182 1,077 561 63%‡ 5,613 [186][187]
2019-03-10 856 65 191 1,112 582 63%‡ 4,830 [188][189]
2019-03-17 886 65 231 1,182 598 63%‡ 4,158 [190][191]
2019-03-25 944 65 226 1,235 629 62%‡ 4,132 [192][193]
2019-03-31 1,016 66 279 1,361 676 62%‡ 6,989 [76][194]
2019-04-07 1,080 66 282 1,428 721 63%‡ 7,099 [195]
2019-04-14 1,185 66 269 1,520 803 64%‡ 10,461 [196]
2019-04-21 1,270 66 92 1,428 870 65%‡ 5,183 [197]
2019-04-28 1,373 66 176 1,615 930 65%‡ 11,841 [198]
2019-05-05 1,488 66 205 1,759 1,028 66%‡ 12,969 [199]
2019-05-12 1,592 88 534 2,214 1,117 67%‡ 13,174 [84]
2019-05-19 1,728 88 278 2,094 1,209 67%‡ 12,608 [200]
2019-05-26 1,818 94 277 2,189 1,277 67%‡ 20,415 [201]
2019-06-02 1,900 94 316 2,310 1,339 67%‡ 19,465 [202]
2019-06-09 1,962 94 271 2,327 1,384 67%‡ 15,045 [203]
2019-06-16
DRC & Uganda		 2,051 / 3 94 / 0 319 / 1 2,468 1,440 67%‡/100%‡ 15,992 / 90 [204][note 1]
2019-06-23 2,145 / 3 94 / 0 276 / 0 2,515 1,506 67%‡/100%‡ 15,903 / 110 [205][6]
2019-06-30 2,231 / 3 94 / 0 309 / 0 2,634 1,563 67%‡/100%‡ 18,088 / 108 [206][207]
2019-07-07 2,314 / 3 94 / 0 323 / 0 2,731 1,625 68%‡/100%‡ 19,227 / 0 [208][209]
2019-07-14 2,407 / 3 94 / 0 335 / 0 2,836 1,665 67%‡/100%‡ 19,118 / 0 [210][209]
2019-07-21 2,484 / 3 94 / 0 361 / 0 2,939 1,737 67%‡/100%‡ 20,505 / 19 [211][212]
DRC.2019-07-28 DRC 2,565 94 358 3,017 1,782 67%‡ 20,072 [213]
2019-08-04 2,659 94 397 3,150 1,843 67%‡ 19,156 [214]
2019-08-11 2,722 94 326 3,142 1,888 67%‡ 15,988 [215]
2019-08-19 2,783 94 387 3,264 1,934 67%‡ 15,817 [216]
2019-08-25 2,863 105 396 3,364 1,986 67%‡ 17,293 [217]
2019-09-01 2,926 105 365 3,396 2,031 67%‡ 16,370 [218]
2019-09-08 2,968 111 403 3,486 2,064 67%‡ 14,737 [219]
2019-09-15 3,005 111 497 3,613 2,090 67%‡ 13,294 [29]
2019-09-22 3,053 111 415 3,583 2,115 67%‡ 11,335 [220]
2019-09-29 3,074 114 426 3,618 2,133 67%‡ 7,775 [221]
2019-10-06 3,090 114 414 3,622 2,146 67%‡ 7,807 [222]
2019-10-13 3,104 114 429 3,647 2,150 67%‡ 5,622 [223]
2019-10-20 3,123 116 420 3,659 2,169 67%‡ 5,570 [224]
2019-10-28 3,146 117 357 3,624 2,180 67%‡ 4,437 [225]
2019-11-03 3,157 117 513 3,787 2,185 67%‡ 6,078 [226]
2019-11-10 3,169 118 482 3,769 2,193 67%‡ 6,137 [227]
2019-11-17 3,174 118 422 3,714 2,195 67%‡ 4,857 [228]
2019-11-24 3,183 118 349 3,650 2,198 67%‡ 3,371 [229]
2019-12-08 3,202 118 391 3,711 2,209 67%‡ 2,955 [230]
2019-12-22 3,240 118 446 3,804 2,224 66%‡ 5,137 [231]
2020-01-05 3,270 118 464 3,852 2,233 66%‡ 4,133 [232]
2020-01-19 3,293 119 438 3,854 2,241 66%‡ 5,018 [233]
2020-02-02 3,305 123 447 3,879 2,250 66%‡ 2,374 [234]
2020-02-16 3,309 123 504 3,936 2,253 66%‡ 1,972 [235]
2020-03-29 3,310 143 232 3,685 2,273 66%‡ - [236]
02020-06-25x 3,313 153 0 3,470 2,280 66%‡ - [1]

# These figures may increase when new cases are discovered, and fall consequently, when tests show cases were not Ebola-related.
† DRC Ministry of Public Health
‡ indicates suspected cases were not counted towards CFR
x indicates 42 days have passed since the last case and outbreak is declared over

Outbreak and military conflict edit

Further information: Second Congo War
Further information: Kivu conflict
 
Goma, the capital of North Kivu province

At the time of the epidemic, there were about 70 armed military groups, among them the Alliance of Patriots for a Free and Sovereign Congo and the Mai-Mayi Nduma défense du Congo-Rénové, in North Kivu. The fighting displaced thousands of individuals[237] and seriously affected the response to the outbreak.[238][239] According to the WHO, health care workers were to be accompanied by military personnel for protection and ring vaccination may not be possible.[240] On 11 August 2018, it was reported that seven individuals were killed in Mayi-Moya due to a militant group, about 24 miles from the city of Beni where there were several EVD cases.[241][242][243]

On 24 August 2018, it was reported that an Ebola-stricken physician had been in contact with 97 individuals in an inaccessible military area, who hence could not be diagnosed.[244][245] In September, it was reported that 2 peacekeepers were attacked and wounded by rebel groups in Beni,[246] and 14 individuals were killed in a military attack.[247] In September 2018, the WHO's Deputy Director-General for Emergency Preparedness and Response described the combination of military conflict and civilian distress as a potential "perfect storm" that could lead to a rapid worsening of the outbreak.[18][19]

On 20 October 2018, an armed rebel group in the DRC killed 13 civilians and took 12 children as hostages in Beni, which was then experiencing one of the worst outbreaks.[248][249] On 11 November, six people were killed in an attack by an armed rebel group in Beni; as a consequence vaccinations were suspended there.[250][251] Yet another attack reported on 17 November, in Beni by an armed rebel group forced the cessation of EVD containment efforts and WHO staff to evacuate to another DRC city for the time being.[252] Beni continued to be the site of attacks by militant groups as 18 civilians were killed on 6 December.[253] On 22 December, it was reported that elections for the President of the DRC would go forward despite the EVD outbreak, including in the Ebola-stricken area of Beni.[254] Four days later, on 26 December, the DRC government reversed itself to indicate those Ebola-stricken areas, such as Beni, would not vote for several months;[255] as a consequence election protesters ransacked an Ebola assessment center in Beni.[256][257][258] Post election tensions continued when it was reported that the DRC government had cut off internet connectivity for the population, as the vote results were yet to be released.[259]

On 29 December 2018, Oxfam said it would suspend its work due to the ongoing violence in the DRC;[260] on the same day, the International Rescue Committee suspended their Ebola support efforts as well.[261] On 18 January, the African Union indicated that presidential election results announcements should be suspended in the DRC.[262]

Pathogen edit

 
Fruit bats (group of Rousettus aegyptiacus)
Further information: Ebola virus
See also: Ebola virus disease § Pathophysiology

The DRC Ministry of Public Health confirmed that the new Ebola outbreak was caused by the Zaire ebolavirus species – the same strain involved in the early 2018 outbreak in western DRC, but different genetic coding.[263][264] The most lethal of the six known strains (including the newly discovered Bombali strain),[265] Zaire ebolavirus strain is fatal in up to 90% of cases.[266] Both Ebola and Marburg virus are part of the Filoviridae family,[267] which is a virus family that causes severe hemorrhagic fever.[268]

The natural reservoir of the virus is thought to be the African fruit bat,[269] which is used in many parts of Africa as bushmeat.[270]

Viral mechanism edit

See also: Ebola virus disease § Virology

A significant part of the actual EVD infection is based on immune suppression along with systemic inflammation, leading to multiple organ failure and shock.[271] Systemic inflammation and fever may damage many types of tissues in the body but the consequences are especially profound in the liver where Ebola wipes out cells required to produce coagulation. In the gastrointestinal tract damaged cells lead to diarrhea putting patients at risk of dehydration. And in the adrenal gland the virus cripples the cells that make steroids which regulate blood pressure, resulting in circulatory collapse.[272]

Genetic epidemiology edit

Genetic epidemiology is a medical field that studies how genetic factors and the environment interact, in this case the outbreak affecting the populations of the Democratic Republic of the Congo and the neighboring country of Uganda. Genetic sequencing had already identified another unrelated strain of Zaire ebolavirus that was implicated in the 2018 outbreak in Équateur province which had ended only a week previously. This was the first time two epidemiologically and genetically distinct outbreaks of Ebola had emerged within weeks of each other.[273][274] In 2020 a third outbreak of Zaire ebolavirus occurred in the DRC. Genome sequencing suggests that this outbreak – the 11th outbreak since the virus was first discovered in the country in 1976 – is related to neither the one in North Kivu Province nor the previous outbreak in the same area in 2018.[275]

 
Genomic epidemiology from July 2018 to Oct. 2019 of the Kivu Ebola epidemic.[276] (One of the first sequence:[277] BEN164, health zone: Mabalako, divergence: 5.285e-5, date: 10/08/18, no nucleotide mutations, to its spread to Goma, sequence: GOM1887, health zone: [aforementioned] Goma, divergence: 2.062e-3, date: 7/13/19, nucleotide mutations: A3376G T3378C C3380A T3386A G3388C G3389T T3391C G3398A C3399A, AA mutations: VP35 V87A Q88K L901 to the more recent sequence: MAN9501, health zone: Mandima, divergence: 1.4803-4, date: 10/10/19, no nucleotide mutations[278] This does not reflect the possible final sequence or information, however as of Oct. 2019 the outbreak was slowing down.[279])

Transmission edit

Ebola virus is found in a variety of bodily fluids, such as breast milk, saliva, stool, blood, and semen, rendering it highly contagious due to ease of contact. Although a few transmission methods are known, there is a possibility that many other methods are unknown and must be further researched. Here are some potential routes of transmission:[280][281]

  • Droplets: Droplet transmission occurs when contact is made with virus-containing droplets.
  • Fomites: Occurs when an individual comes in contact with a pathogen-containing surface.
  • Bodily fluids: The most common way of transmitting the Ebola virus in humans is through contact with infected bodily fluids.

Those infected by EVD generally gain immunity, although it is considered possible that such immunity is only temporary.[282] On 31 October 2019, it was reported that an EVD survivor who had been assisting at a treatment center in Beni had been reinfected with EVD and died; such an incident was unprecedented.[283]

Containment and control edit

Even with the advances made in vaccine technology and treatment options during previous Ebola outbreaks, effective control of the North Kivu Epidemic continued to rely on traditional public health efforts including the timely identification and isolation of cases, control measures in hospital settings, identification and follow-up of contacts, community engagement, and safe burials.[284] Data from the West African Ebola Outbreak showed that response strategies that achieved 60% efficacy for sanitary burial, case isolation, and contact-tracing combined, could have greatly reduced the daily number of Ebola cases and ended the outbreak after only 6 months.[285]

Surveillance and contact tracing edit

Contact tracing is defined as the identification and follow-up of persons who may have been in contact with a person infected with Ebola. Ideally, close contacts are observed for 21 days after their last known exposure to a case and isolated if they become symptomatic. The volume of contacts and the duration of monitoring presented challenges in Ebola surveillance as it required careful record-keeping by properly trained and equipped staff.[286] To strengthen surveillance activities, the DRC Ministry of Health began disseminating standardized Ebola case definitions, developed reporting tools, and communication strategies, and began distribution of daily situation reports.[277] Rapid response teams were deployed to affected health zones to strengthen Ebola case management and infection prevention and control in health care facilities and treatment centers.[277] Similar to the West African Ebola Outbreak, relatively few (less than 10%) Ebola cases presented with hemorrhagic symptoms.[287]

In North Kivu and Ituri, outbreaks of sporadic violence and suspicion of the response in parts of some affected communities impacted heavily on disease surveillance. Poor record keeping by local health facilities also made it difficult or impossible to identify and trace contacts that might have been exposed to the disease while they were undergoing treatment for other illness at health centers. Additionally, the high degree of mobility of affected populations, combined with occasional mistrust of the response has meant that contacts that had been identified have sometimes been lost to follow-up for extended periods.[288] Initially, it was estimated that 30-50% of contacts may not have originally been registered by contact tracing teams.[289]

Community engagement and awareness edit

Surveys among the affected population in North Kivu and Ituri showed both general mistrust with the Ebola response, partly related to years of mistrust of any governmental or external action, and specific opposition to the response because of conflicts with local cultural practices.[290] Some of the cultural practices which complicated the Ebola response included eating bush meat, regular gatherings at family or village events, and traditional funeral practices, which were events that were particularly high risk for Ebola transmission.[290] Additionally, people from the affected region reported that their perception of security and trust in the government, as well as humanitarian workers, declined over the course of the outbreak, complicating an already complex response.[291]

Misinformation edit

See also: Ebola conspiracy theories

Combatting misinformation was a key element in overcoming Ebola in North Kivu. One study using surveys found that low institutional trust coupled with a belief in misinformation about Ebola were inversely associated with preventive behaviors in individuals, including Ebola vaccine acceptance.[292] Belief in misinformation regarding Ebola was widespread, with 25% of respondents reporting that they did not believe the Ebola outbreak was real. Some of the rumors that were being circulated included statements that the outbreak did not exist, it was fabricated by the authorities for financial gains, or was fabricated to destabilize the region.[292] Approximately 68% of respondents reported that they did not trust the local authorities to represent their interest, and community trust in the Ebola response was often further undermined by misinformation spread by local politicians.[292]

Delay in seeking treatment edit

Early in the epidemic there were delays in patients seeking care for Ebola because the initial cases were misdiagnosed. Ebola symptoms were similar to symptoms of more common infectious diseases such as malaria, flu, and typhoid fever so patients would wait until their clinical situation deteriorated dangerously, usually after failure to respond to anti-malarial and/or antibiotic regimens, before reporting to the hospitals.[293]

Burials edit

The IFRC has called funerals "super-spreading events" as burial traditions include kissing and generally touching bodies. Safe burial teams formed by health workers are subject to suspicion.[294]

Travel restrictions and border closings edit

On 26 July 2019, it was reported that the country of Saudi Arabia would not allow visas from the DRC after the WHO declared it an international emergency due to EVD.[295] On 1 August 2019, the country of Rwanda closed its border with the DRC after multiple cases in the city of Goma, which borders the country in the upper Northwestern region.[296]

To minimize the risk of the spread to neighboring countries, screening points which consisted of temperature and symptom monitoring were established at many border crossings. Over 2 million screenings were undertaken during the outbreak which no doubt contributed to the containment of the epidemic within DRC.[297]

Treatment edit

Further information: Ebola virus disease treatment research

In August 2018, the WHO evaluated several drugs used to treat EVD, including Remdesivir, ZMapp, atoltivimab/maftivimab/odesivimab, ansuvimab and favipiravir.[298] The drug ansuvimab (which is a monoclonal antibody) was deployed for the first time to treat infected individuals during this EVD outbreak.[299]

In November 2018, the DRC gave approval to start randomized clinical trials for EVD treatment.[300] On 12 August 2019, it was announced that two clinical trial medications were found to improve the rate of survival in those infected by EVD: atoltivimab/maftivimab/odesivimab, a cocktail of three monoclonal Ebola antibodies, and ansuvimab. These two will be further used in therapy; when used shortly after infection they were found to have a 90% survival rate. ZMapp and Remdesivir were subsequently discontinued.[301][302][303][304]

In October 2020, the U.S. Food and Drug Administration (FDA) approved atoltivimab/maftivimab/odesivimab with an indication for the treatment of infection caused by Zaire ebolavirus.[305]

Vaccination edit

 
Number of vaccinated people in the epidemic area DRC[306]

On 8 August 2018, the process of vaccination began with rVSV-ZEBOV Ebola vaccine.[307] While several studies have shown the vaccine to be safe and protective against the virus, additional research is needed before it can be licensed. Consequently, the WHO reported that it was being used under a ring vaccination strategy with what is known as "compassionate use" to protect persons at highest risk of the Ebola outbreak, i.e. contacts of those infected, contacts of those contacts, and front-line medical personnel.[308] As of 15 September, according to the WHO, almost a quarter of a million individuals had been vaccinated in the outbreak.[29]

On 20 September 2019 it was reported that a second vaccine by Johnson & Johnson would be introduced in the current EVD epidemic in the DRC.[309]

In November 2019, the World Health Organization prequalified an Ebola vaccine, rVSV-ZEBOV, for the first time.[310] As of 22 February 2020, a total of 297,275 people had been vaccinated since the start of the outbreak.[311] By 21 June 2020, 303,905 people had been vaccinated with rVSV-ZEBOV and 20,339 were given the initial dose of Ad26-ZEBOV/MVA-BN-FILO.[312]

Vaccination has helped to contain the epidemic, though military attacks and community resistance have complicated distribution of the vaccines.[313]

Pregnant and lactating women edit

Based on a lack of evidence about the safety of the vaccine during pregnancy, the DRC ministry of health and the WHO decided to cease vaccinating women who were pregnant or lactating. Some authorities criticized this decision as ethically "utterly indefensible". They noted that as caregivers of the sick, pregnant and lactating women are more likely to contract Ebola. They also noted that since it is known that almost 100% of pregnant women who contract Ebola will die, a safety concern should not be a deciding factor.[314] As of June 2019, pregnant and lactating women were also being vaccinated.[315]

Vaccine stockpile edit

The DRC Ministry of Public Health reported on 16 August 2018 that 316 individuals had been vaccinated.[316] On 24 August, the DRC indicated it had vaccinated 2,957 individuals, including 1,422 in Mabalako against the Ebola virus.[317] By late October, more than 20,000 individuals had been vaccinated.[318] In December, Dr. Peter Salama, who is Deputy Director-General of Emergency Preparedness and Response for WHO, reported that the current 300,000 vaccine stockpile might not be enough to contain the EVD outbreak, especially since it takes several months to make more of the Zaire EVD vaccine (rVSV-ZEBOV).[319][320] On 11 December, it was reported that Beni only had 4,290 doses of vaccine in stock.[169]

As of August 2019, Merck & Co, the producers of the vaccine in use, reported a stockpile sufficient for 500,000 individuals, with more in production.[321]

Effectiveness edit

In April 2019, the WHO published the preliminary results of its research, in association with the DRC's Institut National pour la Recherche Biomedicale, into the effectiveness of the ring vaccination program, including data from 93,965 at-risk people who had been vaccinated. WHO stated that the rVSV-ZEBOV-GP vaccine had been 97.5% effective at stopping Ebola transmission.[322][323] The vaccine had also reduced mortality among those who were infected after vaccination. The ring vaccination strategy was effective at reducing EVD in contacts of contacts (tertiary cases), with only two such cases being reported.[323]

Treatment centres edit

In August 2018, the Mangina Ebola Treatment Center was reported to be operational.[324][325] A fourth Ebola Treatment Center (after those in Mangina, Beni and Butembo) was inaugurated in September in Makeke in the Mandima Health Zone of Ituri Province.[326] Makeke is less than five kilometers from Mangina along a well-traveled local road; the site had been proposed in August when it appeared that a second Ebola Treatment Center would be needed in the area, and space was insufficient in Mangina itself to accommodate one.[327] By mid-September, however, there had been only two additional cases in the Mandima Health Zone, and only sporadic cases were being reported in the Mabalako Health Zone.[328]

In February 2019, it was reported that attacks at treatment centers had been carried out in Butembo and Katwa. The motives behind the attacks were unclear. Due to the violence, international aid organizations had to stop their work in the two communities.[329][330] In April, an epidemiologist from WHO was killed and two health workers injured in a militia attack on Butembo University Hospital in Katwa.[331] In May, WHO's health emergencies chief said insecurity had become a "major impediment" to controlling the outbreak. He reported that since January there had been 42 attacks on health facilities and 85 health workers had been wounded or killed. "Every time we have managed to regain control over the virus and contain its spread, we have suffered major, major security events. We are anticipating a scenario of continued intense transmission".[20]

Healthcare workers edit

Health workers must wear personal protection equipment during treatment of those affected by the virus.[332] On 3 September 2018, WHO stated that 16 health workers had contracted the virus.[139] On 10 December, the WHO reported that the current DRC outbreak had led to 49 healthcare workers contracting the Ebola virus, and 15 had died.[168] As of 30 April 2019, there have been 92 health care workers in the DRC infected with EVD, of which 33 had died.[333] With false rumors being spread by word-of-mouth and social media, residents remain mistrustful and fearful of health care workers. In January 2020, it was reported that there had been nearly 400 attacks on medical workers since the outbreak began in 2018.[334]

Post-Ebola virus syndrome edit

Main article: Post-Ebola virus syndrome

In terms of prognosis, aside from the possible effects of post-Ebola syndrome,[335] there is also the reality of survivors returning to communities where they might be shunned due to the fear many have towards the Ebola virus,[336][337] hence psychosocial assistance is needed.[338] Many survivors of EVD face serious side effects, including but not limited to the following:[339][340]

History edit

 
Colorized scanning electron micrograph of Ebola virus particles (green)
Further information: List of Ebola outbreaks and List of epidemics

The Ebola virus disease outbreak in Zaire (Yambuku) started in late 1976, and was the second outbreak ever after the earlier one in Sudan the same year.[341][342] On 1 August 2018, the tenth Ebola outbreak was declared in the DRC, only a few days after a prior outbreak in the same country had been declared over on 24 July.[44][45]

Table 2.
Timeline of Ebola outbreaks in the Democratic Republic of the Congo (formerly Zaire) since 1976
V・T
Date		 Country Major location Outbreak information Source
Strain Cases Deaths CFR
Aug 1976 Zaire Yambuku EBOV 318 280 88% [343]
Jun 1977 Zaire Tandala EBOV 1 1 100% [82][344]
May–Jul 1995 Zaire Kikwit EBOV 315 254 81% [345]
Aug–Nov 2007 Democratic Republic of the Congo Kasai-Occidental EBOV 264 187 71% [346]
Dec 2008–Feb 2009 Democratic Republic of the Congo Kasai-Occidental EBOV 32 14 45% [347]
Jun–Nov 2012 Democratic Republic of the Congo Orientale BDBV 77 36 47% [82]
Aug–Nov 2014 Democratic Republic of the Congo Tshuapa EBOV 66 49 74% [348]
May–Jul 2017 Democratic Republic of the Congo Likati EBOV 8 4 50% [349]
Apr–Jul 2018 Democratic Republic of the Congo Équateur Province EBOV 54 33 61% [350]
Aug 2018–June 2020 Democratic Republic of the Congo Kivu EBOV 3,470 2,280 66% [351]
June–Nov 2020 Democratic Republic of the Congo Équateur Province EBOV 130 55 42% [352]
Feb 2021–May 2021 Democratic Republic of the Congo North Kivu EBOV 12 6 50% [353]
April 2022 Democratic Republic of the Congo Équateur Province EBOV 5 5 100% [354][355]
August 2022 Democratic Republic of the Congo North Kivu EBOV 1 1 100% [356]

Learning from other responses, such as in the 2000 outbreak in Uganda, the WHO established its Global Outbreak Alert and Response Network, and other public health measures were instituted in areas at high risk. Field laboratories were established to confirm cases, instead of shipping samples to South Africa.[357] Additionally, the outbreak was closely monitored by the CDC Special Pathogens Branch.[358]

 
Ebola (and Marburg virus depicted as green squares) outbreaks on the African continent, both from the Filoviridae family[15][359]

Statistical measures edit

One way to measure the outbreak is via the basic reproduction number, R0, a statistical measure of the average number of people expected to be infected by one person with a disease. If the basic reproduction number is less than 1, the infection dies out; if it is greater than 1, the infection continues to spread—with exponential growth in the number of cases.[360] A March 2019 paper by Tariq et al. suggested that R0 was oscillating around 0.9.[361]

Response edit

During the Ebola outbreak in Democratic Republic of the Congo, a number of organizations helped in different capacities: CARITAS DRC, CARE International, Cooperazione Internationale (COOPE), Catholic Organization for Relief and Development Aid (CORDAID/PAP-DRC), International Rescue Committee (IRC), Médecins Sans Frontières (MSF), Oxfam, International Federation of Red Cross and Red Crescent Societies (IFRC), International Committee of the Red Cross (ICRC), and Samaritan's Purse.[141]

WHO edit

 
WHO has only declared six PHEICs in its history.[362]

On 12 April 2019, the WHO Emergency Committee was reconvened by the WHO Director-General after an increase in the rate of new cases, and determined that the outbreak still failed to meet the criteria for a Public Health Emergency of International Concern (PHEIC).[363][364]

Following the confirmation of Ebola crossing into Uganda, a third review by the WHO on 14 June 2019[24] concluded that while the outbreak was a health emergency in the DRC and the region, it did not meet all three criteria required for a PHEIC.[25] Following a case in Goma, the reconvening of a fourth review was announced on 15 July 2019.[27] The WHO officially declared the situation a PHEIC on 17 July 2019,[28] and as of 12 February 2020, it continues to be a PHEIC.[365]

Sex abuse accusations edit

In September 2021, a commission found that between 2018 and 2020, WHO staff had engaged in sex abuse and rape. The report prompted WHO's chief Tedros Adhanom to issue a formal apology to those women and girls affected.[366][367]

World Bank edit

The World Bank was criticised when its Pandemic Emergency Financing Facility, intended to support countries affected by pandemic diseases, had only paid out $31 million of a potential total of $425 million by August 2019 while generating substantial returns for investors. The conditions used to decide when the fund should pay out to disease-affected countries were criticised as too stringent.[368]

International governments edit

Financial support has been contributed by the governments of the US and the UK, among others. The UK DfID minister, Rory Stewart, visited the area in July 2019, and called for other western countries, including Canada, France and Germany, to donate more financial aid. He identified a funding deficit of $100–300 million to continue responding to the outbreak until December. He urged WHO to classify the situation as a PHEIC, to facilitate the release of international aid.[369][370]

Subsequent outbreaks and other regional health issues edit

2020 Équateur province edit

On 1 June 2020, the Congolese health ministry announced a new DRC outbreak of Ebola in Mbandaka, Équateur Province, a region along the Congo River. This area was the site of the 2018 Équateur province Ebola outbreak, which infected 53 people and resulted in 29 deaths. That outbreak was quickly brought under control with the use of the Ebola vaccine.

Genome sequencing suggested that this 2020 outbreak, the 11th outbreak since the virus was first discovered in the country in 1976, was unrelated to the one in North Kivu Province or the previous outbreak in the same area in 2018. It was reported that six cases had been identified with four fatalities. It was expected that more people would be identified as surveillance activities increased.[275]

The WHO assisted with the response to this outbreak in part using the structures put in place for the 2018 outbreak. Testing and contact tracing was used and additional medical staff had been sent in.[371] Médecins Sans Frontières was also on hand to give assistance if needed. The outbreak added to an already difficult time for the Congo due to both COVID-19 cases and a large measles outbreak that has caused more than 7,000 deaths as of August 2020.[35]

By 8 June, a total of 12 cases had been identified in and around Mbandaka and 6 deaths due to the virus. The WHO said 300 people in Mbandaka and the surrounding Équateur province had been vaccinated.[372] By 15 June the case count had increased to 17 with 11 deaths, with more than 2,500 people having been vaccinated.[373] On 17 October, it had increased to 128 cases and 53 deaths, despite an effective vaccine being available.[374] As of 18 November, the World Health Organization has had no reported cases of Ebola in Équateur province for 42 days; therefore the outbreak is over.[36] In the end there were 130 cases and 55 dead due to the virus.[37]

Notes edit

  1. ^ a b c ...in the Congolese statistics cases of Mabalako. Uganda's index case and 7 other family members were classified in Mabalako, the health zone where they started to develop symptoms. Of these 8 confirmed cases of the same family, 5 remained in the DRC and 3 had crossed the border. [...] The 2 deaths of Bwera are the 5-year-old boy and the 50-year-old grandmother who were classified...[8]
  2. ^ Ituri province was added to N. Kivu province, in terms of viral infection, when the first case of EVD was confirmed on 13 August.[9]

References edit

  This article was submitted to WikiJournal of Medicine for external academic peer review in 2021 (reviewer reports). The updated content was reintegrated into the Wikipedia page under a CC-BY-SA-3.0 license (2022). The version of record as reviewed is: Osmin Anis; et al. (13 April 2022). "The Kivu Ebola epidemic" (PDF). WikiJournal of Medicine. 9 (1): 1. doi:10.15347/WJM/2022.001. ISSN 2002-4436. Wikidata Q105411509.

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December 21, 2023
kivu, ebola, epidemic, this, article, about, ebola, virus, outbreak, democratic, republic, congo, uganda, prior, ebola, outbreak, 2018, Équateur, province, ebola, outbreak, note, outbreak, ebola, virus, disease, mainly, eastern, democratic, republic, congo, ot. This article is about an Ebola virus outbreak in the Democratic Republic of the Congo and Uganda For the prior Ebola outbreak in DRC see 2018 Equateur province Ebola outbreak The Kivu Ebola epidemic note 2 was an outbreak of Ebola virus disease EVD mainly in eastern Democratic Republic of the Congo DRC and in other parts of Central Africa from 2018 to 2020 10 Between 1 August 2018 and 25 June 2020 it resulted in 3 470 reported cases 11 The Kivu outbreak also affected Ituri Province whose first case was confirmed on 13 August 2018 9 In November 2018 the outbreak became the biggest Ebola outbreak in the DRC s history 12 13 14 and had become the second largest Ebola outbreak in recorded history worldwide 11 15 behind only the 2013 2016 Western Africa epidemic 11 16 In June 2019 the virus reached Uganda having infected a 5 year old Congolese boy who entered Uganda with his family 17 but was contained 11 Kivu Ebola epidemicDemocratic Republic of the Congo amp Uganda areas affected by the epidemic Date1 August 2018 2018 08 01 25 June 2020 2020 06 25 1 CasualtiesCountryCases conf prob susp DeathsLast updateDRC3 313 153 02 266 1 2 Uganda4 0 04 3 4 5 6 7 Total3 470 note 1 2 280 note 1 As of 25 June 2020A military conflict in the region that had begun in January 2015 hindered treatment and prevention efforts The World Health Organization WHO described the combination of military conflict and civilian distress as a potential perfect storm that could lead to a rapid worsening of the outbreak 18 19 In May 2019 the WHO reported that since January 85 health workers had been wounded or killed in 42 attacks on health facilities In some areas aid organizations had to stop their work due to violence 20 Health workers also had to deal with misinformation spread by opposing politicians 21 Due to the deteriorating security situation in North Kivu and surrounding areas the WHO raised the risk assessment at the national and regional level from high to very high in September 2018 22 In October the United Nations Security Council stressed that all armed hostility in the DRC should come to a stop to better fight the ongoing EVD outbreak 23 24 25 A confirmed case in Goma triggered the decision by the WHO to convene an emergency committee for the fourth time 26 27 and on 17 July 2019 the WHO announced a Public Health Emergency of International Concern PHEIC the highest level of alarm the WHO can sound 28 On 15 September 2019 some slowdown of EVD cases was noted by the WHO in DRC 29 However contact tracing continued to be less than 100 at the time it was at 89 29 As of mid October the transmission of the virus had significantly reduced by then it was confined to the Mandima region near where the outbreak began and was only affecting 27 health zones in the DRC down from a peak of 207 30 New cases dwindled to zero by 17 February 2020 31 but after 52 days without a case surveillance and response teams on the ground confirmed three new cases of Ebola in Beni health zone in mid April 32 33 34 On 25 June 2020 the outbreak was declared ended 1 16 As a new and separate outbreak the Congolese health ministry reported on 1 June 2020 that there were cases of Ebola in Equateur Province in north western DRC described as the eleventh Ebola outbreak since records began 35 This separate outbreak was declared over as of 18 November following no reported cases for 42 days 36 and caused 130 cases and 55 deaths 37 Contents 1 Epidemiology 1 1 Democratic Republic of the Congo 1 1 1 Becoming the 2nd biggest EVD outbreak 1 1 2 Spread to Goma 1 1 3 Spread to South Kivu Province 1 2 Uganda 1 3 Tanzania 1 4 Countries with medically evacuated individuals 1 5 Outbreak and military conflict 2 Pathogen 2 1 Viral mechanism 2 2 Genetic epidemiology 3 Transmission 4 Containment and control 4 1 Surveillance and contact tracing 4 2 Community engagement and awareness 4 2 1 Misinformation 4 2 2 Delay in seeking treatment 4 3 Burials 4 4 Travel restrictions and border closings 5 Treatment 5 1 Vaccination 5 1 1 Pregnant and lactating women 5 1 2 Vaccine stockpile 5 1 3 Effectiveness 5 2 Treatment centres 5 2 1 Healthcare workers 6 Post Ebola virus syndrome 7 History 8 Statistical measures 9 Response 9 1 WHO 9 1 1 Sex abuse accusations 9 2 World Bank 9 3 International governments 10 Subsequent outbreaks and other regional health issues 10 1 2020 Equateur province 11 Notes 12 References 13 Further reading 14 External links 14 1 VideoEpidemiology editAs indicated below and per numbers offered by the United Nations the final death toll was 2 280 with a total of 3 470 cases in DRC in almost a two year period This was made very difficult due to the ongoing military attacks in the region which created a perfect storm for the virus despite there being a vaccine 38 rVSV ZEBOV or Ebola Zaire vaccine live is a vaccine that prevents Ebola caused by the Zaire ebolavirus 39 The graph of reported cases reflects cases that were not able to have a laboratory test sample before burial as probable cases 40 nbsp Note Above graph begins in Aug 2018 at one month intervals then progresses to two month intervals as the outbreak intensifies at beginning of 2019 then finally has a four month interval until it is declared over due to a flare up just days prior to the first two 21 day period to call the outbreak over per WHO which caused a restart of the coutdown 2018 19 Kivu Ebola epidemic total cases deaths as of 25 June 2020 1 x indicates 2 21 day periods have passed and outbreak is overDemocratic Republic of the Congo edit nbsp Map of the Democratic Republic of the Congo North Kivu orange middle South Kivu dark red bottom and Ituri green top On 1 August 2018 the North Kivu health division notified Congo s health ministry of 26 cases of hemorrhagic fever including 20 deaths Four of the six samples that were sent for analysis to the National Institute of Biological Research in Kinshasa came back positive for Ebola and an outbreak was declared on that date 41 42 The index case is believed to have been the death and unsafe burial of a 65 year old woman on 25 July in Mangina quickly followed by the deaths of seven close family members 43 This outbreak started just days after the end of the outbreak in Equateur province 44 45 On 1 August just after the Ebola epidemic had been declared Doctors Without Borders Medecins Sans Frontieres MSF arrived in Mangina the point of origin of the outbreak to mount a response 46 On 2 August Oxfam indicated it would be taking part in the response to this latest outbreak in the DRC 47 On 4 August the WHO indicated that the current situation in the DRC due to several factors warranted a high risk assessment at the national and regional level for public health 48 By 3 August the virus had developed in multiple locations cases were reported in five health zones Beni Butembo Oicha Musienene and Mabalako in North Kivu province as well as Mandima and Mambasa in Ituri Province 49 However one month later there had been confirmed cases only in the Mabalako Mandima Beni and Oicha health zones The five suspected cases in the Mambasa Health Zone proved not to be EVD it was not possible to confirm the one probable case in the Musienene Health Zone and the two probable cases in the Butembo Health Zone No new cases had been recorded in any of those health zones 50 WHO chief Tedros Adhanom Ghebreyesu indicated on 15 August that the outbreak then in the DRC might be worse than the West African outbreak of 2013 2016 51 with the IRC connecting this to the ongoing Kivu conflict 52 The Kivu outbreak was the biggest of the ten recorded outbreaks recorded in the DRC 53 The first confirmed case in Butembo was announced on 4 September the same day that it was announced that one of the cases registered at Beni had actually come from the Kalunguta Health Zone 50 In November it was reported that the EVD outbreak ran across two provinces and 14 health zones 40 By 23 December the EVD outbreak had spread to more health zones and at that time 18 such areas had been affected 54 Becoming the 2nd biggest EVD outbreak edit On 7 August 2018 the DRC Ministry of Public Health indicated that the total count had climbed to almost 90 cases 55 and the Uganda Ministry of Health issued an alert for extra surveillance as the outbreak was just 100 kilometres 62 mi away from its border 56 Two days later the total count was nearly 100 cases 57 On 16 August the United Kingdom indicated it would help with EVD diagnosis and monitoring in the DRC 58 On 17 August 2018 the WHO reported that there were around 1 500 contacts while noting that certain conflict zones in the DRC that could not be reached might have contained more contacts 59 Some 954 contacts were successfully followed up on 18 August however Mandima Health Zone indicated resistance so contacts were not followed up there 60 On 4 September Butembo a city with almost one million people and an international airport recorded its first fatality in the Ebola outbreak The city of Butembo in the DRC has trade links to nearby Uganda 61 50 On 24 September it was reported that all contact tracing and vaccinations would stop for the foreseeable future in Beni due to a deadly attack by rebel groups the day before 62 On 25 September Peter Salama of the WHO indicated that insecurity was obstructing efforts to stop the virus and believed a combination of factors could establish conditions for an epidemic 63 On 18 October the U S Centers for Disease Control and Prevention CDC raised its travelers alert to the DRC from a level 1 to level 2 for all U S travelers 64 On 26 October the WHO indicated that half of confirmed cases were not showing any fever symptoms thus making diagnosis more difficult 65 According to a September 2018 Lancet survey 25 of respondents in Beni and Butembo believed the Ebola outbreak to be a hoax These beliefs correlated with decreased likelihood of seeking healthcare or accepting vaccination 66 On 6 November 2018 the CDC indicated that the current outbreak in the east region of the DRC was potentially non containable This would be the first time since 1976 that an outbreak was not able to be curbed 67 On 13 November the WHO indicated that the viral outbreak would last at least six months 68 On 29 December 2018 the DRC Ministry of Public Health announced that there had been 0 new confirmed cases detected because of the paralysis of the activities of the response in Beni Butembo Komanda and Mabalako and no vaccination had occurred for three consecutive days 69 On 22 January the total case count approached 1 000 cases 951 suspected in the DRC Ministry of Public Health situation report 70 The graphs below demonstrate the EVD intensity in different locations in the DRC as well as in the West African epidemic of 2014 15 as a comparison nbsp Mabalako between 16 July and 31 December 2018 71 nbsp Beni between 23 July 2018 and 28 January 2019 72 nbsp Katwa orange and Butembo purple between 23 July 2018 and 4 February 2019 73 nbsp Western Africa Ebola Epidemic for comparison with current outbreak 74 On 16 March 2019 the director of the CDC indicated that the outbreak in the DRC could last another year additionally suggesting that vaccine supplies could run out 75 According to the WHO resistance to vaccination in the Kaniyi Health Zone was ongoing as of March 2019 76 There was still a belief by some in surrounding areas that the epidemic was a hoax 77 nbsp Democratic Republic of the Congo EVD outbreaks 1976 9 November 2018 Note total cases for this date does not reflect 52 suspected cases nor does it reflect the final case numbers 12 78 Uganda has second most EVD cases 00 01 425 79 West African Ebola virus epidemic 13 16 gt 28 000 80 Until the outbreak in North Kivu in 2018 no outbreak had surpassed 320 total cases in the Democratic Republic of the Congo By 24 February 2019 the epidemic had surpassed 1 000 total cases 1 048 81 82 On 10 May 2019 the U S Centers for Disease Control and Prevention indicated that the outbreak could eventually surpass the West African epidemic 83 The 12 May 2019 issue of WHO Weekly Bulletin on Outbreaks and Other Emergencies indicates that continued increase in the number of new EVD cases in the Democratic Republic of the Congo is worrying no end in sight to the difficult security situation 84 On 25 November 2019 it was reported that violence had broken out in Beni again to such a degree that some aid agencies had evacuated According to the same report around 300 individuals might have been exposed to EVD via an infected individual 85 Spread to Goma edit On 14 July 2019 the first case of EVD was confirmed in the capital of North Kivu Goma a city with an international airport and a highly mobile population of 2 million people located near the DRC s eastern border with Rwanda 86 87 88 89 This case was a man who had passed through three health checkpoints with different names on traveller lists 27 The WHO stated that he died in a treatment centre 90 whereas according to Reuters he died en route to a treatment centre 91 This case triggered the decision by the WHO to again reconvene an emergency committee 26 27 where the situation was officially declared a Public Health Emergency of International Concern 28 On 30 July a second case of EVD was confirmed in the city of Goma apparently not linked to the first case 92 Across the border from Goma in the country of Rwanda Ebola simulation drills were being conducted at health facilities 93 A third case of EVD was confirmed in Goma on 1 August 94 On 22 August 2019 Nyiragongo Health Zone the affected area on the outskirts of Goma reached 21 days without further cases being confirmed 95 Spread to South Kivu Province edit On 16 August 2019 it was reported that the Ebola virus disease had spread to a third province South Kivu via two new cases who had travelled from Beni North Kivu 96 97 By 22 August the number of cases in Mwenga had risen to four including one person at a health facility visited by the first case 98 Uganda edit Further information Refugees of Uganda nbsp Map of Uganda District Kasese in Western RegionIn August 2018 a UN agency indicated that active screening was deployed to ensure that those leaving the DRC into Uganda were not infected with Ebola 99 The government of Uganda opened two Ebola treatment centers at the border with the DRC though there had not yet been any confirmed cases in the country of Uganda 100 101 By 13 June 2019 nine treatment units were in place near the affected border 102 According to the International Red Cross a most likely scenario entailed an asymptomatic case entering the country of Uganda undetected among the numerous refugees then coming from the DRC 103 On 20 September Uganda indicated it was ready for immediate vaccination should the Ebola virus be detected in any individual 104 105 On 21 September officials of the DRC indicated a confirmed case of EVD at Lake Albert an entry point into Uganda though no cases were then confirmed within Ugandan territory 106 107 On 2 November it was reported that the Ugandan government would start vaccinating health workers along the border with the DRC as a proactive measure against the virus 108 Vaccinations started on 7 November and by 13 June 2019 4 699 health workers at 165 sites had been vaccinated 102 Proactive vaccination was also carried out in South Sudan with 1 471 health workers vaccinated by 7 May 2019 109 On 2 January 2019 it was reported that refugee movement from the DRC to Uganda had increased after the presidential elections 110 On 12 February it was reported that 13 individuals had been isolated due to their contact with a suspected Ebola case in Uganda 111 lab results came back negative several hours later 112 On 11 June 2019 the WHO reported that the virus had spread to Uganda A 5 year old Congolese boy entered Uganda on the previous Sunday with his family to seek medical care On 12 June the WHO reported that the 5 year old patient had died while 2 more cases of Ebola infection within the same family were also confirmed 17 113 On 14 June it was reported that there were 112 contacts since EVD was first detected in Uganda 114 Ring vaccination of Ugandan contacts was scheduled to start on 15 June 25 As of 18 June 2019 275 contacts had been vaccinated per the Uganda Ministry of Health 115 On 14 July an individual entered the country of Uganda from DRC while symptomatic for EVD a search for contacts in Mpondwe followed 116 On 24 July Uganda marked the needed 42 day period without any EVD cases to be declared Ebola free 117 On 29 August a 9 year old Congolese girl became the fourth individual in Uganda to test positive for EVD when she crossed from the DRC into the district of Kasese 118 Tanzania edit nbsp Map of United Republic of TanzaniaIn regards to possible EVD cases in Tanzania the WHO stated on 21 September 2019 that to date the clinical details and the results of the investigation including laboratory tests performed for differential diagnosis of these patients have not been shared with WHO The insufficient information received by WHO does not allow for a formulation of a hypotheses regarding the possible cause of the illness 119 120 121 On 27 September the CDC and U S State Department alerted potential travellers to the possibility of unreported EVD cases within Tanzania 122 The Tanzanian Health Minister Ummy Mwalimu stated on 3 October 2019 that there was no Ebola outbreak in Tanzania 123 The WHO were provided with a preparedness update on 18 October which outlined a range of actions and included commentary that since the outbreak commenced there had been 29 alerts of Ebola suspect cases reported 17 samples tested and were negative for Ebola including 2 in September 2019 124 Countries with medically evacuated individuals edit On 29 December an American physician who was exposed to the Ebola virus and who was non symptomatic was evacuated and taken to the University of Nebraska Medical Center 125 126 On 12 January the individual was released after 21 days without symptoms 127 The table which follows indicates confirmed probable and suspected cases as well as deaths the table also indicates the multiple countries where these cases took place during this outbreak Table 1 Timeline of reported cases 78 Date Cases Deaths CFR Contacts SourcesConfirmed Probable Suspected TotalsDRC 2018 08 01 DRC 4 22 0 26 20 128 2018 08 03 13 30 33 76 33 0 76 7 879 129 130 2018 08 05 16 27 31 74 34 79 966 131 132 2018 08 10 25 27 48 100 39 75 953 133 2018 08 12 30 27 58 115 41 997 134 2018 08 17 64 27 12 103 50 0 55 6 1 609 60 2018 08 20 75 27 9 111 59 2 408 135 2018 08 24 83 28 6 117 72 65 3 421 136 2018 08 26 83 28 10 121 75 0 67 6 2 445 137 2018 08 31 90 30 8 128 78 65 2 462 138 2018 09 02 91 31 9 131 82 2 512 139 2018 09 07 100 31 14 145 89 68 2 426 140 2018 09 09 101 31 9 141 91 2 265 141 142 2018 09 14 106 31 17 154 92 0 67 2 1 751 143 2018 09 16 111 31 7 149 97 2 173 144 145 2018 09 21 116 31 n a 147 99 0 67 3 1 641 146 2018 09 23 119 31 9 159 100 67 1 836 147 2018 09 28 126 31 23 180 102 65 1 410 148 2018 10 02 130 32 17 179 106 0 65 4 1 463 149 2018 10 05 142 35 11 188 113 0 63 8 2 045 150 2018 10 07 146 35 21 202 115 0 63 5 2 115 151 2018 10 12 176 35 32 243 135 64 2 663 152 2018 10 15 181 35 32 248 139 64 4 707 153 2018 10 19 202 35 33 270 153 65 5 518 154 2018 10 21 203 35 14 252 155 65 5 341 155 2018 10 26 232 35 43 310 170 64 6 026 65 2018 10 28 239 35 32 306 174 0 63 5 5 991 156 2018 11 02 263 35 70 368 186 0 62 4 5 036 157 2018 11 04 265 35 61 361 186 62 4 971 158 2018 11 09 294 35 60 389 205 62 4 779 159 2018 11 11 295 38 n a 333 209 4 803 160 2018 11 16 319 47 49 415 214 59 4 430 161 2018 11 21 326 47 90 463 217 4 668 162 2018 11 23 365 47 45 457 236 57 4 354 163 2018 11 26 374 47 74 495 241 57 4 767 164 2018 11 30 392 48 63 503 255 58 4 820 165 2018 12 03 405 48 79 532 268 59 5 335 166 2018 12 07 446 48 95 589 283 57 6 417 167 2018 12 10 452 48 n a 500 289 58 6 509 168 2018 12 14 483 48 111 642 313 59 6 695 169 2018 12 21 526 48 118 692 347 60 8 422 170 2018 12 28 548 48 52 648 361 61 7 007 171 2019 01 04 575 48 118 741 374 60 5 047 172 2019 01 11 595 49 n a 644 390 61 4 937 173 2019 01 18 636 49 209 894 416 61 4 971 174 175 2019 01 25 679 54 204 937 459 63 6 241 176 177 2019 02 01 720 54 168 942 481 62 gt 7 000 178 179 2019 02 10 750 61 148 959 510 63 7 846 180 181 2019 02 18 773 65 135 973 534 64 6 772 182 183 2019 02 24 804 65 219 1 088 546 63 5 739 184 185 2019 03 03 830 65 182 1 077 561 63 5 613 186 187 2019 03 10 856 65 191 1 112 582 63 4 830 188 189 2019 03 17 886 65 231 1 182 598 63 4 158 190 191 2019 03 25 944 65 226 1 235 629 62 4 132 192 193 2019 03 31 1 016 66 279 1 361 676 62 6 989 76 194 2019 04 07 1 080 66 282 1 428 721 63 7 099 195 2019 04 14 1 185 66 269 1 520 803 64 10 461 196 2019 04 21 1 270 66 92 1 428 870 65 5 183 197 2019 04 28 1 373 66 176 1 615 930 65 11 841 198 2019 05 05 1 488 66 205 1 759 1 028 66 12 969 199 2019 05 12 1 592 88 534 2 214 1 117 67 13 174 84 2019 05 19 1 728 88 278 2 094 1 209 67 12 608 200 2019 05 26 1 818 94 277 2 189 1 277 67 20 415 201 2019 06 02 1 900 94 316 2 310 1 339 67 19 465 202 2019 06 09 1 962 94 271 2 327 1 384 67 15 045 203 2019 06 16 DRC amp Uganda 2 051 3 94 0 319 1 2 468 1 440 67 100 15 992 90 204 note 1 2019 06 23 2 145 3 94 0 276 0 2 515 1 506 67 100 15 903 110 205 6 2019 06 30 2 231 3 94 0 309 0 2 634 1 563 67 100 18 088 108 206 207 2019 07 07 2 314 3 94 0 323 0 2 731 1 625 68 100 19 227 0 208 209 2019 07 14 2 407 3 94 0 335 0 2 836 1 665 67 100 19 118 0 210 209 2019 07 21 2 484 3 94 0 361 0 2 939 1 737 67 100 20 505 19 211 212 DRC 2019 07 28 DRC 2 565 94 358 3 017 1 782 67 20 072 213 2019 08 04 2 659 94 397 3 150 1 843 67 19 156 214 2019 08 11 2 722 94 326 3 142 1 888 67 15 988 215 2019 08 19 2 783 94 387 3 264 1 934 67 15 817 216 2019 08 25 2 863 105 396 3 364 1 986 67 17 293 217 2019 09 01 2 926 105 365 3 396 2 031 67 16 370 218 2019 09 08 2 968 111 403 3 486 2 064 67 14 737 219 2019 09 15 3 005 111 497 3 613 2 090 67 13 294 29 2019 09 22 3 053 111 415 3 583 2 115 67 11 335 220 2019 09 29 3 074 114 426 3 618 2 133 67 7 775 221 2019 10 06 3 090 114 414 3 622 2 146 67 7 807 222 2019 10 13 3 104 114 429 3 647 2 150 67 5 622 223 2019 10 20 3 123 116 420 3 659 2 169 67 5 570 224 2019 10 28 3 146 117 357 3 624 2 180 67 4 437 225 2019 11 03 3 157 117 513 3 787 2 185 67 6 078 226 2019 11 10 3 169 118 482 3 769 2 193 67 6 137 227 2019 11 17 3 174 118 422 3 714 2 195 67 4 857 228 2019 11 24 3 183 118 349 3 650 2 198 67 3 371 229 2019 12 08 3 202 118 391 3 711 2 209 67 2 955 230 2019 12 22 3 240 118 446 3 804 2 224 66 5 137 231 2020 01 05 3 270 118 464 3 852 2 233 66 4 133 232 2020 01 19 3 293 119 438 3 854 2 241 66 5 018 233 2020 02 02 3 305 123 447 3 879 2 250 66 2 374 234 2020 02 16 3 309 123 504 3 936 2 253 66 1 972 235 2020 03 29 3 310 143 232 3 685 2 273 66 236 0 2020 06 25x 3 313 153 0 3 470 2 280 66 1 These figures may increase when new cases are discovered and fall consequently when tests show cases were not Ebola related DRC Ministry of Public Health indicates suspected cases were not counted towards CFRx indicates 42 days have passed since the last case and outbreak is declared overOutbreak and military conflict edit Further information Second Congo War Further information Kivu conflict nbsp Goma the capital of North Kivu provinceAt the time of the epidemic there were about 70 armed military groups among them the Alliance of Patriots for a Free and Sovereign Congo and the Mai Mayi Nduma defense du Congo Renove in North Kivu The fighting displaced thousands of individuals 237 and seriously affected the response to the outbreak 238 239 According to the WHO health care workers were to be accompanied by military personnel for protection and ring vaccination may not be possible 240 On 11 August 2018 it was reported that seven individuals were killed in Mayi Moya due to a militant group about 24 miles from the city of Beni where there were several EVD cases 241 242 243 On 24 August 2018 it was reported that an Ebola stricken physician had been in contact with 97 individuals in an inaccessible military area who hence could not be diagnosed 244 245 In September it was reported that 2 peacekeepers were attacked and wounded by rebel groups in Beni 246 and 14 individuals were killed in a military attack 247 In September 2018 the WHO s Deputy Director General for Emergency Preparedness and Response described the combination of military conflict and civilian distress as a potential perfect storm that could lead to a rapid worsening of the outbreak 18 19 On 20 October 2018 an armed rebel group in the DRC killed 13 civilians and took 12 children as hostages in Beni which was then experiencing one of the worst outbreaks 248 249 On 11 November six people were killed in an attack by an armed rebel group in Beni as a consequence vaccinations were suspended there 250 251 Yet another attack reported on 17 November in Beni by an armed rebel group forced the cessation of EVD containment efforts and WHO staff to evacuate to another DRC city for the time being 252 Beni continued to be the site of attacks by militant groups as 18 civilians were killed on 6 December 253 On 22 December it was reported that elections for the President of the DRC would go forward despite the EVD outbreak including in the Ebola stricken area of Beni 254 Four days later on 26 December the DRC government reversed itself to indicate those Ebola stricken areas such as Beni would not vote for several months 255 as a consequence election protesters ransacked an Ebola assessment center in Beni 256 257 258 Post election tensions continued when it was reported that the DRC government had cut off internet connectivity for the population as the vote results were yet to be released 259 On 29 December 2018 Oxfam said it would suspend its work due to the ongoing violence in the DRC 260 on the same day the International Rescue Committee suspended their Ebola support efforts as well 261 On 18 January the African Union indicated that presidential election results announcements should be suspended in the DRC 262 Pathogen edit nbsp Fruit bats group of Rousettus aegyptiacus Further information Ebola virus See also Ebola virus disease Pathophysiology The DRC Ministry of Public Health confirmed that the new Ebola outbreak was caused by the Zaire ebolavirus species the same strain involved in the early 2018 outbreak in western DRC but different genetic coding 263 264 The most lethal of the six known strains including the newly discovered Bombali strain 265 Zaire ebolavirus strain is fatal in up to 90 of cases 266 Both Ebola and Marburg virus are part of the Filoviridae family 267 which is a virus family that causes severe hemorrhagic fever 268 The natural reservoir of the virus is thought to be the African fruit bat 269 which is used in many parts of Africa as bushmeat 270 Viral mechanism edit See also Ebola virus disease Virology A significant part of the actual EVD infection is based on immune suppression along with systemic inflammation leading to multiple organ failure and shock 271 Systemic inflammation and fever may damage many types of tissues in the body but the consequences are especially profound in the liver where Ebola wipes out cells required to produce coagulation In the gastrointestinal tract damaged cells lead to diarrhea putting patients at risk of dehydration And in the adrenal gland the virus cripples the cells that make steroids which regulate blood pressure resulting in circulatory collapse 272 Genetic epidemiology edit Genetic epidemiology is a medical field that studies how genetic factors and the environment interact in this case the outbreak affecting the populations of the Democratic Republic of the Congo and the neighboring country of Uganda Genetic sequencing had already identified another unrelated strain of Zaire ebolavirus that was implicated in the 2018 outbreak in Equateur province which had ended only a week previously This was the first time two epidemiologically and genetically distinct outbreaks of Ebola had emerged within weeks of each other 273 274 In 2020 a third outbreak of Zaire ebolavirus occurred in the DRC Genome sequencing suggests that this outbreak the 11th outbreak since the virus was first discovered in the country in 1976 is related to neither the one in North Kivu Province nor the previous outbreak in the same area in 2018 275 nbsp Genomic epidemiology from July 2018 to Oct 2019 of the Kivu Ebola epidemic 276 One of the first sequence 277 BEN164 health zone Mabalako divergence 5 285e 5 date 10 08 18 no nucleotide mutations to its spread to Goma sequence GOM1887 health zone aforementioned Goma divergence 2 062e 3 date 7 13 19 nucleotide mutations A3376G T3378C C3380A T3386A G3388C G3389T T3391C G3398A C3399A AA mutations VP35 V87A Q88K L901 to the more recent sequence MAN9501 health zone Mandima divergence 1 4803 4 date 10 10 19 no nucleotide mutations 278 This does not reflect the possible final sequence or information however as of Oct 2019 the outbreak was slowing down 279 Transmission editEbola virus is found in a variety of bodily fluids such as breast milk saliva stool blood and semen rendering it highly contagious due to ease of contact Although a few transmission methods are known there is a possibility that many other methods are unknown and must be further researched Here are some potential routes of transmission 280 281 Droplets Droplet transmission occurs when contact is made with virus containing droplets Fomites Occurs when an individual comes in contact with a pathogen containing surface Bodily fluids The most common way of transmitting the Ebola virus in humans is through contact with infected bodily fluids Those infected by EVD generally gain immunity although it is considered possible that such immunity is only temporary 282 On 31 October 2019 it was reported that an EVD survivor who had been assisting at a treatment center in Beni had been reinfected with EVD and died such an incident was unprecedented 283 Containment and control editEven with the advances made in vaccine technology and treatment options during previous Ebola outbreaks effective control of the North Kivu Epidemic continued to rely on traditional public health efforts including the timely identification and isolation of cases control measures in hospital settings identification and follow up of contacts community engagement and safe burials 284 Data from the West African Ebola Outbreak showed that response strategies that achieved 60 efficacy for sanitary burial case isolation and contact tracing combined could have greatly reduced the daily number of Ebola cases and ended the outbreak after only 6 months 285 Surveillance and contact tracing edit Contact tracing is defined as the identification and follow up of persons who may have been in contact with a person infected with Ebola Ideally close contacts are observed for 21 days after their last known exposure to a case and isolated if they become symptomatic The volume of contacts and the duration of monitoring presented challenges in Ebola surveillance as it required careful record keeping by properly trained and equipped staff 286 To strengthen surveillance activities the DRC Ministry of Health began disseminating standardized Ebola case definitions developed reporting tools and communication strategies and began distribution of daily situation reports 277 Rapid response teams were deployed to affected health zones to strengthen Ebola case management and infection prevention and control in health care facilities and treatment centers 277 Similar to the West African Ebola Outbreak relatively few less than 10 Ebola cases presented with hemorrhagic symptoms 287 In North Kivu and Ituri outbreaks of sporadic violence and suspicion of the response in parts of some affected communities impacted heavily on disease surveillance Poor record keeping by local health facilities also made it difficult or impossible to identify and trace contacts that might have been exposed to the disease while they were undergoing treatment for other illness at health centers Additionally the high degree of mobility of affected populations combined with occasional mistrust of the response has meant that contacts that had been identified have sometimes been lost to follow up for extended periods 288 Initially it was estimated that 30 50 of contacts may not have originally been registered by contact tracing teams 289 Community engagement and awareness edit Surveys among the affected population in North Kivu and Ituri showed both general mistrust with the Ebola response partly related to years of mistrust of any governmental or external action and specific opposition to the response because of conflicts with local cultural practices 290 Some of the cultural practices which complicated the Ebola response included eating bush meat regular gatherings at family or village events and traditional funeral practices which were events that were particularly high risk for Ebola transmission 290 Additionally people from the affected region reported that their perception of security and trust in the government as well as humanitarian workers declined over the course of the outbreak complicating an already complex response 291 Misinformation edit See also Ebola conspiracy theories Combatting misinformation was a key element in overcoming Ebola in North Kivu One study using surveys found that low institutional trust coupled with a belief in misinformation about Ebola were inversely associated with preventive behaviors in individuals including Ebola vaccine acceptance 292 Belief in misinformation regarding Ebola was widespread with 25 of respondents reporting that they did not believe the Ebola outbreak was real Some of the rumors that were being circulated included statements that the outbreak did not exist it was fabricated by the authorities for financial gains or was fabricated to destabilize the region 292 Approximately 68 of respondents reported that they did not trust the local authorities to represent their interest and community trust in the Ebola response was often further undermined by misinformation spread by local politicians 292 Delay in seeking treatment edit Early in the epidemic there were delays in patients seeking care for Ebola because the initial cases were misdiagnosed Ebola symptoms were similar to symptoms of more common infectious diseases such as malaria flu and typhoid fever so patients would wait until their clinical situation deteriorated dangerously usually after failure to respond to anti malarial and or antibiotic regimens before reporting to the hospitals 293 Burials edit The IFRC has called funerals super spreading events as burial traditions include kissing and generally touching bodies Safe burial teams formed by health workers are subject to suspicion 294 Travel restrictions and border closings edit On 26 July 2019 it was reported that the country of Saudi Arabia would not allow visas from the DRC after the WHO declared it an international emergency due to EVD 295 On 1 August 2019 the country of Rwanda closed its border with the DRC after multiple cases in the city of Goma which borders the country in the upper Northwestern region 296 To minimize the risk of the spread to neighboring countries screening points which consisted of temperature and symptom monitoring were established at many border crossings Over 2 million screenings were undertaken during the outbreak which no doubt contributed to the containment of the epidemic within DRC 297 Treatment editFurther information Ebola virus disease treatment research In August 2018 the WHO evaluated several drugs used to treat EVD including Remdesivir ZMapp atoltivimab maftivimab odesivimab ansuvimab and favipiravir 298 The drug ansuvimab which is a monoclonal antibody was deployed for the first time to treat infected individuals during this EVD outbreak 299 In November 2018 the DRC gave approval to start randomized clinical trials for EVD treatment 300 On 12 August 2019 it was announced that two clinical trial medications were found to improve the rate of survival in those infected by EVD atoltivimab maftivimab odesivimab a cocktail of three monoclonal Ebola antibodies and ansuvimab These two will be further used in therapy when used shortly after infection they were found to have a 90 survival rate ZMapp and Remdesivir were subsequently discontinued 301 302 303 304 In October 2020 the U S Food and Drug Administration FDA approved atoltivimab maftivimab odesivimab with an indication for the treatment of infection caused by Zaire ebolavirus 305 Vaccination edit nbsp Number of vaccinated people in the epidemic area DRC 306 On 8 August 2018 the process of vaccination began with rVSV ZEBOV Ebola vaccine 307 While several studies have shown the vaccine to be safe and protective against the virus additional research is needed before it can be licensed Consequently the WHO reported that it was being used under a ring vaccination strategy with what is known as compassionate use to protect persons at highest risk of the Ebola outbreak i e contacts of those infected contacts of those contacts and front line medical personnel 308 As of 15 September according to the WHO almost a quarter of a million individuals had been vaccinated in the outbreak 29 On 20 September 2019 it was reported that a second vaccine by Johnson amp Johnson would be introduced in the current EVD epidemic in the DRC 309 In November 2019 the World Health Organization prequalified an Ebola vaccine rVSV ZEBOV for the first time 310 As of 22 February 2020 a total of 297 275 people had been vaccinated since the start of the outbreak 311 By 21 June 2020 303 905 people had been vaccinated with rVSV ZEBOV and 20 339 were given the initial dose of Ad26 ZEBOV MVA BN FILO 312 Vaccination has helped to contain the epidemic though military attacks and community resistance have complicated distribution of the vaccines 313 Pregnant and lactating women edit Based on a lack of evidence about the safety of the vaccine during pregnancy the DRC ministry of health and the WHO decided to cease vaccinating women who were pregnant or lactating Some authorities criticized this decision as ethically utterly indefensible They noted that as caregivers of the sick pregnant and lactating women are more likely to contract Ebola They also noted that since it is known that almost 100 of pregnant women who contract Ebola will die a safety concern should not be a deciding factor 314 As of June 2019 pregnant and lactating women were also being vaccinated 315 Vaccine stockpile edit The DRC Ministry of Public Health reported on 16 August 2018 that 316 individuals had been vaccinated 316 On 24 August the DRC indicated it had vaccinated 2 957 individuals including 1 422 in Mabalako against the Ebola virus 317 By late October more than 20 000 individuals had been vaccinated 318 In December Dr Peter Salama who is Deputy Director General of Emergency Preparedness and Response for WHO reported that the current 300 000 vaccine stockpile might not be enough to contain the EVD outbreak especially since it takes several months to make more of the Zaire EVD vaccine rVSV ZEBOV 319 320 On 11 December it was reported that Beni only had 4 290 doses of vaccine in stock 169 As of August 2019 Merck amp Co the producers of the vaccine in use reported a stockpile sufficient for 500 000 individuals with more in production 321 Effectiveness edit In April 2019 the WHO published the preliminary results of its research in association with the DRC s Institut National pour la Recherche Biomedicale into the effectiveness of the ring vaccination program including data from 93 965 at risk people who had been vaccinated WHO stated that the rVSV ZEBOV GP vaccine had been 97 5 effective at stopping Ebola transmission 322 323 The vaccine had also reduced mortality among those who were infected after vaccination The ring vaccination strategy was effective at reducing EVD in contacts of contacts tertiary cases with only two such cases being reported 323 Treatment centres edit In August 2018 the Mangina Ebola Treatment Center was reported to be operational 324 325 A fourth Ebola Treatment Center after those in Mangina Beni and Butembo was inaugurated in September in Makeke in the Mandima Health Zone of Ituri Province 326 Makeke is less than five kilometers from Mangina along a well traveled local road the site had been proposed in August when it appeared that a second Ebola Treatment Center would be needed in the area and space was insufficient in Mangina itself to accommodate one 327 By mid September however there had been only two additional cases in the Mandima Health Zone and only sporadic cases were being reported in the Mabalako Health Zone 328 In February 2019 it was reported that attacks at treatment centers had been carried out in Butembo and Katwa The motives behind the attacks were unclear Due to the violence international aid organizations had to stop their work in the two communities 329 330 In April an epidemiologist from WHO was killed and two health workers injured in a militia attack on Butembo University Hospital in Katwa 331 In May WHO s health emergencies chief said insecurity had become a major impediment to controlling the outbreak He reported that since January there had been 42 attacks on health facilities and 85 health workers had been wounded or killed Every time we have managed to regain control over the virus and contain its spread we have suffered major major security events We are anticipating a scenario of continued intense transmission 20 Healthcare workers edit Health workers must wear personal protection equipment during treatment of those affected by the virus 332 On 3 September 2018 WHO stated that 16 health workers had contracted the virus 139 On 10 December the WHO reported that the current DRC outbreak had led to 49 healthcare workers contracting the Ebola virus and 15 had died 168 As of 30 April 2019 there have been 92 health care workers in the DRC infected with EVD of which 33 had died 333 With false rumors being spread by word of mouth and social media residents remain mistrustful and fearful of health care workers In January 2020 it was reported that there had been nearly 400 attacks on medical workers since the outbreak began in 2018 334 Post Ebola virus syndrome editMain article Post Ebola virus syndromeIn terms of prognosis aside from the possible effects of post Ebola syndrome 335 there is also the reality of survivors returning to communities where they might be shunned due to the fear many have towards the Ebola virus 336 337 hence psychosocial assistance is needed 338 Many survivors of EVD face serious side effects including but not limited to the following 339 340 Joint pain Muscle pain Chest pain Hearing loss Hair loss Memory problems Anxiety attacks Vision lossHistory edit nbsp Colorized scanning electron micrograph of Ebola virus particles green Further information List of Ebola outbreaks and List of epidemics The Ebola virus disease outbreak in Zaire Yambuku started in late 1976 and was the second outbreak ever after the earlier one in Sudan the same year 341 342 On 1 August 2018 the tenth Ebola outbreak was declared in the DRC only a few days after a prior outbreak in the same country had been declared over on 24 July 44 45 Table 2 dd Timeline of Ebola outbreaks in the Democratic Republic of the Congo formerly Zaire since 1976 V TDate Country Major location Outbreak information SourceStrain Cases Deaths CFRAug 1976 Zaire Yambuku EBOV 318 280 88 343 Jun 1977 Zaire Tandala EBOV 1 1 100 82 344 May Jul 1995 Zaire Kikwit EBOV 315 254 81 345 Aug Nov 2007 Democratic Republic of the Congo Kasai Occidental EBOV 264 187 71 346 Dec 2008 Feb 2009 Democratic Republic of the Congo Kasai Occidental EBOV 32 14 45 347 Jun Nov 2012 Democratic Republic of the Congo Orientale BDBV 77 36 47 82 Aug Nov 2014 Democratic Republic of the Congo Tshuapa EBOV 66 49 74 348 May Jul 2017 Democratic Republic of the Congo Likati EBOV 8 4 50 349 Apr Jul 2018 Democratic Republic of the Congo Equateur Province EBOV 54 33 61 350 Aug 2018 June 2020 Democratic Republic of the Congo Kivu EBOV 3 470 2 280 66 351 June Nov 2020 Democratic Republic of the Congo Equateur Province EBOV 130 55 42 352 Feb 2021 May 2021 Democratic Republic of the Congo North Kivu EBOV 12 6 50 353 April 2022 Democratic Republic of the Congo Equateur Province EBOV 5 5 100 354 355 August 2022 Democratic Republic of the Congo North Kivu EBOV 1 1 100 356 Learning from other responses such as in the 2000 outbreak in Uganda the WHO established its Global Outbreak Alert and Response Network and other public health measures were instituted in areas at high risk Field laboratories were established to confirm cases instead of shipping samples to South Africa 357 Additionally the outbreak was closely monitored by the CDC Special Pathogens Branch 358 nbsp Ebola and Marburg virus depicted as green squares outbreaks on the African continent both from the Filoviridae family 15 359 Statistical measures editOne way to measure the outbreak is via the basic reproduction number R0 a statistical measure of the average number of people expected to be infected by one person with a disease If the basic reproduction number is less than 1 the infection dies out if it is greater than 1 the infection continues to spread with exponential growth in the number of cases 360 A March 2019 paper by Tariq et al suggested that R0 was oscillating around 0 9 361 Response editDuring the Ebola outbreak in Democratic Republic of the Congo a number of organizations helped in different capacities CARITAS DRC CARE International Cooperazione Internationale COOPE Catholic Organization for Relief and Development Aid CORDAID PAP DRC International Rescue Committee IRC Medecins Sans Frontieres MSF Oxfam International Federation of Red Cross and Red Crescent Societies IFRC International Committee of the Red Cross ICRC and Samaritan s Purse 141 WHO edit nbsp WHO has only declared six PHEICs in its history 362 On 12 April 2019 the WHO Emergency Committee was reconvened by the WHO Director General after an increase in the rate of new cases and determined that the outbreak still failed to meet the criteria for a Public Health Emergency of International Concern PHEIC 363 364 Following the confirmation of Ebola crossing into Uganda a third review by the WHO on 14 June 2019 24 concluded that while the outbreak was a health emergency in the DRC and the region it did not meet all three criteria required for a PHEIC 25 Following a case in Goma the reconvening of a fourth review was announced on 15 July 2019 27 The WHO officially declared the situation a PHEIC on 17 July 2019 28 and as of 12 February 2020 it continues to be a PHEIC 365 Sex abuse accusations edit In September 2021 a commission found that between 2018 and 2020 WHO staff had engaged in sex abuse and rape The report prompted WHO s chief Tedros Adhanom to issue a formal apology to those women and girls affected 366 367 World Bank edit The World Bank was criticised when its Pandemic Emergency Financing Facility intended to support countries affected by pandemic diseases had only paid out 31 million of a potential total of 425 million by August 2019 while generating substantial returns for investors The conditions used to decide when the fund should pay out to disease affected countries were criticised as too stringent 368 International governments edit Financial support has been contributed by the governments of the US and the UK among others The UK DfID minister Rory Stewart visited the area in July 2019 and called for other western countries including Canada France and Germany to donate more financial aid He identified a funding deficit of 100 300 million to continue responding to the outbreak until December He urged WHO to classify the situation as a PHEIC to facilitate the release of international aid 369 370 Subsequent outbreaks and other regional health issues edit2020 Equateur province edit On 1 June 2020 the Congolese health ministry announced a new DRC outbreak of Ebola in Mbandaka Equateur Province a region along the Congo River This area was the site of the 2018 Equateur province Ebola outbreak which infected 53 people and resulted in 29 deaths That outbreak was quickly brought under control with the use of the Ebola vaccine Genome sequencing suggested that this 2020 outbreak the 11th outbreak since the virus was first discovered in the country in 1976 was unrelated to the one in North Kivu Province or the previous outbreak in the same area in 2018 It was reported that six cases had been identified with four fatalities It was expected that more people would be identified as surveillance activities increased 275 The WHO assisted with the response to this outbreak in part using the structures put in place for the 2018 outbreak Testing and contact tracing was used and additional medical staff had been sent in 371 Medecins Sans Frontieres was also on hand to give assistance if needed The outbreak added to an already difficult time for the Congo due to both COVID 19 cases and a large measles outbreak that has caused more than 7 000 deaths as of August 2020 35 By 8 June a total of 12 cases had been identified in and around Mbandaka and 6 deaths due to the virus The WHO said 300 people in Mbandaka and the surrounding Equateur province had been vaccinated 372 By 15 June the case count had increased to 17 with 11 deaths with more than 2 500 people having been vaccinated 373 On 17 October it had increased to 128 cases and 53 deaths despite an effective vaccine being available 374 As of 18 November the World Health Organization has had no reported cases of Ebola in Equateur province for 42 days therefore the outbreak is over 36 In the end there were 130 cases and 55 dead due to the virus 37 Notes edit a b c in the Congolese statistics cases of Mabalako Uganda s index case and 7 other family members were classified in Mabalako the health zone where they started to develop symptoms Of these 8 confirmed cases of the same family 5 remained in the DRC and 3 had crossed the border The 2 deaths of Bwera are the 5 year old boy and the 50 year old grandmother who were classified 8 Ituri province was added to N Kivu province in terms of viral infection when the first case of EVD was confirmed on 13 August 9 References edit nbsp This article was submitted to WikiJournal of Medicine for external academic peer review in 2021 reviewer reports The updated content was reintegrated into the Wikipedia page under a CC BY SA 3 0 license 2022 The version of record as reviewed is Osmin Anis et al 13 April 2022 The Kivu Ebola epidemic PDF WikiJournal of Medicine 9 1 1 doi 10 15347 WJM 2022 001 ISSN 2002 4436 Wikidata Q105411509 a b c d e DR Congo s 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Monoclonal Antibody for Treatment of Ebola Virus Infection Office of Technology Transfer NIH www ott nih gov Archived from the original on 12 June 2018 Retrieved 14 August 2018 EBOLA RDC Evolution de la riposte contre l epidemie d Ebola dans la province du Nord Kivu au Mardi 18 septembre 2018 mailchi mp in French Retrieved 19 September 2018 EBOLA RDC Evolution de la riposte contre l epidemie d Ebola dans la province du Nord Kivu au Lundi 20 aout 2018 mailchi mp in French Retrieved 19 September 2018 Ebola virus disease Democratic Republic of the Congo Disease Outbreak News 14 September 2018 World Health Organization WHO Archived from the original on 17 September 2018 Retrieved 19 September 2018 Congo Ebola Center Set on Fire After Armed Attack VOA 27 February 2019 Retrieved 1 March 2019 cite, wikipedia, wiki, book, books, library,

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