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Haplogroup M8

In human mitochondrial genetics, Haplogroup M8 is a human mitochondrial DNA (mtDNA) haplogroup.[2][3]

Haplogroup M8
Possible time of origin34,400 YBP[1]
Possible place of originEast Asia
AncestorM
DescendantsM8a, CZ
Defining mutationsA4715G C7196a G8584A A15487t T16298C[1]

Origin edit

Haplogroup M8 is a descendant of haplogroup M. Haplogroup M8 is divided into subclades M8a, C and Z.

Distribution edit

It is an East Asian haplogroup. Today, haplogroup M8 is found at its highest frequency in indigenous populations of East Siberia such as Evenk and Yukaghir. Haplogroup M8 is one of the most common mtDNA haplogroups among Yakut, Tuvan. Haplogroup C, the most major one of three subclades is highly distributed among the Amerindian and Indigienous peoples of East Siberia. Haplogroup Z, the other one of three subclades is highly distributed among Even from Kamchatka (8/39 Z1a2a, 3/39 Z1a3, 11/39 = 28.2% Z total), mtDNA Haplogroup M8a, not well known one of three subclades is highly distributed among Northern Han Chinese from Liaoning (16/317 = 5.0%).

Table of Frequencies by ethnic group edit

Population Frequency Count Source Subclades
Yakut 0.407 378 Pakendorf 2006 C=153, Z=1
Mongolian 0.277 47 Jin 2009 M8a=1, C=10, Z=2
Xibe (Xinjiang) 0.145 137 [citation needed] C=13, Z=7
Han Chinese (Liaoning) 0.120 317 [citation needed] M8a=16, C=14, Z=8
Korean (Chungcheong) 0.103 117 [citation needed] -
Han Chinese (Shandong) 0.099 393 [citation needed] M8a=8, C=14, Z=17
Han Chinese (Shanghai) 0.097 51 [citation needed] M8a=7, C=5, Z=2
Han Chinese (Henan) 0.086 208 [citation needed] M8a=9, C=7, Z=2
Korean (Gangwon) 0.079 114 [citation needed] -
Manchurian 0.075 40 Jin 2009 M8a=1, C=1, Z=1
Korean (Gyeongsang) 0.071 112 [citation needed] -
Korean (Seoul) 0.067 134 [citation needed] -
Korean (Jeolla) 0.059 118 [citation needed] -
Korean (Gwangju) 0.033 60 [citation needed] M8a=2
Japanese 0.032 1312 Tanaka 2004 M8a=18, C=7, Z=17
Vietnamese 0.029 35 [citation needed] -
Han Chinese (South) 0.026 78 [citation needed] -
Korean (Jeju Island) 0.009 113 [citation needed] -
Okinawan 0.003 326 Umetsu 2005 CZ=1
Taiwan Aboriginal 0.000 640 Trejaut 2005 -
Philippines 0.000 59 Tajima 2004 -

Subclades edit

Haplogroup C, the most major one of three subclades is highly distributed among the Amerindian and Indigienous peoples of East Siberia. Haplogroup Z, the other one of three subclades is highly distributed among Even from Kamchatka (8/39 Z1a2a, 3/39 Z1a3, 11/39 = 28.2% Z total), mtDNA Haplogroup M8a, not well known one of three subclades is highly distributed among Northern Han Chinese from Liaoning (16/317 = 5.0%).

Tree edit

This phylogenetic tree of haplogroup M8 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • M8
    • M8a
      • M8a1 - Ulch
        • M8a1a - Japanese
      • M8a2'3
        • M8a2 - Japanese, Han Chinese
        • M8a2-a* - Japanese, Russia
          • M8a2a'b (T152C!) - Japanese
            • M8a2a - Han Chinese
              • M8a2a1 - Japanese, Han Chinese(Hunan)
                • M8a2a1a1
              • M8a2a1b
              • M8a2a1c - Japanese
            • M8a2b - Japanese, Han Chinese (Shandong)
              • M8a2b1
              • M8a2b2 - Russia
          • M8a2c - Japanese, Han Chinese
          • M8a2d - Han Chinese
          • M8a2e - Ami(Taiwan Aborigines), Han Chinese (Taiwan)
        • M8a3 - Japanese, Han Chinese
          • M8a3a - Han Chinese
            • M8a3a1 - Han Chinese
    • CZ
      • C
        • C1
          • C1a - Ulch, Swedish
          • C1b - Amerindian
            • C1b1
            • C1b2
            • C1b3
            • C1b4
            • C1b5
              • C1b5a
              • C1b5b
            • C1b6
            • C1b7'10 (T16311C!)
              • C1b7
                • C1b7a
              • C1b10
            • C1b8
            • C1b9
            • C1b11
            • C1b12
            • C1b13
              • C1b13a
                • C1b13a1
              • C1b13b
              • C1b13c
                • C1b13c1
              • C1b13d
              • C1b13e
            • C1b14
          • C1c - Amerindian
            • C1c1
              • C1c1a
              • C1c1b
            • C1c2
            • C1c3
            • C1c4
            • C1c5
            • C1c6'7
              • C1c6
              • C1c7
            • C1c8
          • C1d - Amerindian
            • C1d1
              • C1d1a
                • C1d1a1
              • C1d1b
                • C1d1b1
              • C1d1c
                • C1d1c1
              • C1d1d
            • C1d2
              • C1d2a
            • C1d3
          • C1e - Amerindian
          • C1f - Amerindian
        • C4 - Siberian, Mongolian, Han Chinese
          • C4a'b'c
            • C4a
              • C4a1
                • C4a1a
                  • C4a1a1
                    • C4a1a1a
                  • C4a1a2'3'4
                    • C4a1a2
                      • C4a1a2a
                    • C4a1a3
                      • C4a1a3a
                        • C4a1a3a1
                      • C4a1a3b
                      • C4a1a3c
                      • C4a1a3d
                    • C4a1a4
                      • C4a1a4a
                  • C4a1a5
                  • C4a1a6
              • C4a2
                • C4a2a
                  • C4a2a1
                    • C4a2a1a
                    • C4a2a1b
                • C4a2b
                  • C4a2b1
                  • C4a2b2
                    • C4a2b2a
                • C4a2c
                  • C4a2c1
                  • C4a2c2
                    • C4a2c2a
            • C4b
              • C4b1
                • C4b1a
                • C4b1b
              • C4b2
                • C4b2a
              • C4b3
                • C4b3a
                  • C4b3a1
                • C4b3b
              • C4b5
              • C4b6
              • C4b7
              • C4b8
                • C4b8a
            • C4c
              • C4c1
                • C4c1a
                • C4c1b
              • C4c2
          • C4d'e
            • C4d
            • C4e
          • C5 - Siberian, Mongolian, Han Chinese
            • C5a
              • C5a1
              • C5a2
                • C5a2a
                • C5a2b
                  • C5a2b1
            • C5b
              • C5b1
                • C5b1a
                  • C5b1a1
                • C5b1b
                  • C5b1b1
            • C5c'd
              • C5c
                • C5c1
                  • C5c1a
              • C5d
                • C5d1
                • C5d2
          • C7 - Han Chinese, Indo-China Penisulan
            • C7a
              • C7a1
                • C7a1a
                  • C7a1a1
                  • C7a1a2
                • C7a1c
                • C7a1d
              • C7a2
                • C7a2a
            • C7b
        • Z
          • Z1'2'3'4'7
            • Z1 - Tofalar
              • Z1a - Tubalar
                • Z1a1
                  • Z1a1a - Saami, Kets
                  • Z1a1b - Nganasan, Estonian
                • Z1a2 - Ulch
                  • Z1a2a - Nivkh
                • Z1a3 - Yakuts, Estonian
            • Z2 - Japanese
            • Z3 - Japanese
      • Z3a
        • Z3a1
          • Z3a1a - Han Chinese, Indian
        • Z3a2 - Indian
      • Z3b - Indian
        • Z3c - Persian(Iranian), Japanese
        • Z3d - Han Chinese, Taiwanese
            • Z4 - Han Chinese
              • Z4a - Japanese
                • Z4a1 - Han Chinese
                  • Z4a1a
                    • Z4a1a1 - Japanese
            • Z7 - Indian
          • Z5 - Japanese

See also edit

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T


References edit

  1. ^ a b c van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.
  2. ^ "Figure 1 Kaplan-Meier plot of haplogroup D4 and M8. A: Kaplan-Meier..." ResearchGate. Retrieved 2020-01-17.
  3. ^ "Figure 2: Phylogenetic network of C, Z and M8 HVR1 sequences revealed..." ResearchGate. Retrieved 2020-01-17.

Bibliography edit

  • Gómez-Carballa, Alberto; Catelli, Laura (November 12, 2015). "The complete mitogenome of a 500-year-old Inca child mummy". Scientific Reports. 5: 16462. Bibcode:2015NatSR...516462G. doi:10.1038/srep16462. PMC 4642457. PMID 26561991.
  • Jin, Han-Jun; Tyler-Smith, Chris; Kim, Wook (2009). Batzer, Mark A (ed.). "The Peopling of Korea Revealed by Analyses of Mitochondrial DNA and Y-Chromosomal Markers". PLOS ONE. 4 (1): e4210. Bibcode:2009PLoSO...4.4210J. doi:10.1371/journal.pone.0004210. PMC 2615218. PMID 19148289.
  • Pakendorf, Brigitte; Novgorodov, Innokentij N.; Osakovskij, Vladimir L.; Danilova, Al’bina P.; Protod’jakonov, Artur P.; Stoneking, Mark (October 2006). "Investigating the effects of prehistoric migrations in Siberia: genetic variation and the origins of Yakuts". Human Genetics. 120 (3): 334–353. doi:10.1007/s00439-006-0213-2. PMID 16845541. S2CID 31651899.
  • Atsushi Tajima; et al. (March 2, 2004). "Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages". Journal of Human Genetics. 49 (4): 187–193. doi:10.1007/s10038-004-0131-x. OCLC 110247689. PMID 14997363.
  • Tanaka, Masashi; Cabrera, Vicente M.; González, Ana M.; Larruga, José M.; Takeyasu, Takeshi; Fuku, Noriyuki; Guo, Li-Jun; Hirose, Raita; Fujita, Yasunori; Kurata, Miyuki; Shinoda, Ken-ichi; Umetsu, Kazuo; Yamada, Yoshiji; Oshida, Yoshiharu; Sato, Yuzo; Hattori, Nobutaka; Mizuno, Yoshikuni; Arai, Yasumichi; Hirose, Nobuyoshi; Ohta, Shigeo; Ogawa, Osamu; Tanaka, Yasushi; Kawamori, Ryuzo; Shamoto-Nagai, Masayo; Maruyama, Wakako; Shimokata, Hiroshi; Suzuki, Ryota; Shimodaira, Hidetoshi (October 2004). "Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan". Genome Research. 14 (10a): 1832–1850. doi:10.1101/gr.2286304. PMC 524407. PMID 15466285.
  • Trejaut, Jean A.; Kivisild, Toomas; Loo, Jun Hun; Lee, Chien Liang; He, Chun Lin; Hsu, Chia Jung; Lee, Zheng Yuan; Lin, Marie (2005). "Traces of Archaic Mitochondrial Lineages Persist in Austronesian-Speaking Formosan Populations". PLOS Biology. 3 (8). e247. doi:10.1371/journal.pbio.0030247. PMC 1166350. PMID 15984912.
  • Umetsu, Kazuo; Tanaka, Masashi; Yuasa, Isao; et al. (2005). "Multiplex amplified product-length polymorphism analysis of 36 mitochondrial single-nucleotide polymorphisms for haplogrouping of East Asian populations". Electrophoresis. 26 (1): 91–98. doi:10.1002/elps.200406129. PMID 15624129. S2CID 44989190.

External links edit

  • General
    • 47z TAT's blog
    • Mannis van Oven's Phylotree
  • Haplogroup M8
    • Ian Logan's Mitochondrial DNA Site: Haplogroup M8

haplogroup, this, article, about, human, mtdna, haplogroup, human, mtdna, haplogroup, haplogroup, mtdna, human, mitochondrial, genetics, human, mitochondrial, mtdna, haplogroup, possible, time, origin34, possible, place, origineast, asiaancestormdescendantsm8a. This article is about the human mtDNA haplogroup For the human mtDNA haplogroup see Haplogroup C mtDNA In human mitochondrial genetics Haplogroup M8 is a human mitochondrial DNA mtDNA haplogroup 2 3 Haplogroup M8Possible time of origin34 400 YBP 1 Possible place of originEast AsiaAncestorMDescendantsM8a CZDefining mutationsA4715G C7196a G8584A A15487t T16298C 1 Contents 1 Origin 2 Distribution 2 1 Table of Frequencies by ethnic group 3 Subclades 3 1 Tree 4 See also 5 References 6 Bibliography 7 External linksOrigin editHaplogroup M8 is a descendant of haplogroup M Haplogroup M8 is divided into subclades M8a C and Z Distribution editIt is an East Asian haplogroup Today haplogroup M8 is found at its highest frequency in indigenous populations of East Siberia such as Evenk and Yukaghir Haplogroup M8 is one of the most common mtDNA haplogroups among Yakut Tuvan Haplogroup C the most major one of three subclades is highly distributed among the Amerindian and Indigienous peoples of East Siberia Haplogroup Z the other one of three subclades is highly distributed among Even from Kamchatka 8 39 Z1a2a 3 39 Z1a3 11 39 28 2 Z total mtDNA Haplogroup M8a not well known one of three subclades is highly distributed among Northern Han Chinese from Liaoning 16 317 5 0 Table of Frequencies by ethnic group edit Population Frequency Count Source SubcladesYakut 0 407 378 Pakendorf 2006 C 153 Z 1Mongolian 0 277 47 Jin 2009 M8a 1 C 10 Z 2Xibe Xinjiang 0 145 137 citation needed C 13 Z 7Han Chinese Liaoning 0 120 317 citation needed M8a 16 C 14 Z 8Korean Chungcheong 0 103 117 citation needed Han Chinese Shandong 0 099 393 citation needed M8a 8 C 14 Z 17Han Chinese Shanghai 0 097 51 citation needed M8a 7 C 5 Z 2Han Chinese Henan 0 086 208 citation needed M8a 9 C 7 Z 2Korean Gangwon 0 079 114 citation needed Manchurian 0 075 40 Jin 2009 M8a 1 C 1 Z 1Korean Gyeongsang 0 071 112 citation needed Korean Seoul 0 067 134 citation needed Korean Jeolla 0 059 118 citation needed Korean Gwangju 0 033 60 citation needed M8a 2Japanese 0 032 1312 Tanaka 2004 M8a 18 C 7 Z 17Vietnamese 0 029 35 citation needed Han Chinese South 0 026 78 citation needed Korean Jeju Island 0 009 113 citation needed Okinawan 0 003 326 Umetsu 2005 CZ 1Taiwan Aboriginal 0 000 640 Trejaut 2005 Philippines 0 000 59 Tajima 2004 Subclades editHaplogroup C the most major one of three subclades is highly distributed among the Amerindian and Indigienous peoples of East Siberia Haplogroup Z the other one of three subclades is highly distributed among Even from Kamchatka 8 39 Z1a2a 3 39 Z1a3 11 39 28 2 Z total mtDNA Haplogroup M8a not well known one of three subclades is highly distributed among Northern Han Chinese from Liaoning 16 317 5 0 Tree edit This phylogenetic tree of haplogroup M8 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation 1 and subsequent published research M8 M8a M8a1 Ulch M8a1a Japanese M8a2 3 M8a2 Japanese Han Chinese M8a2 a Japanese Russia M8a2a b T152C Japanese M8a2a Han Chinese M8a2a1 Japanese Han Chinese Hunan M8a2a1a1 M8a2a1b M8a2a1c Japanese M8a2b Japanese Han Chinese Shandong M8a2b1 M8a2b2 Russia M8a2c Japanese Han Chinese M8a2d Han Chinese M8a2e Ami Taiwan Aborigines Han Chinese Taiwan M8a3 Japanese Han Chinese M8a3a Han Chinese M8a3a1 Han Chinese CZ C C1 C1a Ulch Swedish C1b Amerindian C1b1 C1b2 C1b3 C1b4 C1b5 C1b5a C1b5b C1b6 C1b7 10 T16311C C1b7 C1b7a C1b10 C1b8 C1b9 C1b11 C1b12 C1b13 C1b13a C1b13a1 C1b13b C1b13c C1b13c1 C1b13d C1b13e C1b14 C1c Amerindian C1c1 C1c1a C1c1b C1c2 C1c3 C1c4 C1c5 C1c6 7 C1c6 C1c7 C1c8 C1d Amerindian C1d1 C1d1a C1d1a1 C1d1b C1d1b1 C1d1c C1d1c1 C1d1d C1d2 C1d2a C1d3 C1e Amerindian C1f Amerindian C4 Siberian Mongolian Han Chinese C4a b c C4a C4a1 C4a1a C4a1a1 C4a1a1a C4a1a2 3 4 C4a1a2 C4a1a2a C4a1a3 C4a1a3a C4a1a3a1 C4a1a3b C4a1a3c C4a1a3d C4a1a4 C4a1a4a C4a1a5 C4a1a6 C4a2 C4a2a C4a2a1 C4a2a1a C4a2a1b C4a2b C4a2b1 C4a2b2 C4a2b2a C4a2c C4a2c1 C4a2c2 C4a2c2a C4b C4b1 C4b1a C4b1b C4b2 C4b2a C4b3 C4b3a C4b3a1 C4b3b C4b5 C4b6 C4b7 C4b8 C4b8a C4c C4c1 C4c1a C4c1b C4c2 C4d e C4d C4e C5 Siberian Mongolian Han Chinese C5a C5a1 C5a2 C5a2a C5a2b C5a2b1 C5b C5b1 C5b1a C5b1a1 C5b1b C5b1b1 C5c d C5c C5c1 C5c1a C5d C5d1 C5d2 C7 Han Chinese Indo China Penisulan C7a C7a1 C7a1a C7a1a1 C7a1a2 C7a1c C7a1d C7a2 C7a2a C7b Z Z1 2 3 4 7 Z1 Tofalar Z1a Tubalar Z1a1 Z1a1a Saami Kets Z1a1b Nganasan Estonian Z1a2 Ulch Z1a2a Nivkh Z1a3 Yakuts Estonian Z2 Japanese Z3 Japanese Z3a Z3a1 Z3a1a Han Chinese Indian Z3a2 Indian Z3b Indian Z3c Persian Iranian Japanese Z3d Han Chinese Taiwanese Z4 Han Chinese Z4a Japanese Z4a1 Han Chinese Z4a1a Z4a1a1 Japanese Z7 Indian Z5 JapaneseSee also edit nbsp Wikimedia Commons has media related to Haplogroup C mtDNA Genealogical DNA test Genetic Genealogy Human mitochondrial genetics Population Genetics Human mitochondrial DNA haplogroups Indigenous American genetic studiesPhylogenetic tree of human mitochondrial DNA mtDNA haplogroups Mitochondrial Eve L L0 L1 6 L1 L2 L3 L4 L5 L6M N CZ D E G Q O A S R I W X YC Z B F R0 pre JT P UHV JT KH V J TReferences edit a b c van Oven Mannis Manfred Kayser 13 Oct 2008 Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation Human Mutation 30 2 E386 E394 doi 10 1002 humu 20921 PMID 18853457 S2CID 27566749 Figure 1 Kaplan Meier plot of haplogroup D4 and M8 A Kaplan Meier ResearchGate Retrieved 2020 01 17 Figure 2 Phylogenetic network of C Z and M8 HVR1 sequences revealed ResearchGate Retrieved 2020 01 17 Bibliography editGomez Carballa Alberto Catelli Laura November 12 2015 The complete mitogenome of a 500 year old Inca child mummy Scientific Reports 5 16462 Bibcode 2015NatSR 516462G doi 10 1038 srep16462 PMC 4642457 PMID 26561991 Jin Han Jun Tyler Smith Chris Kim Wook 2009 Batzer Mark A ed The Peopling of Korea Revealed by Analyses of Mitochondrial DNA and Y Chromosomal Markers PLOS ONE 4 1 e4210 Bibcode 2009PLoSO 4 4210J doi 10 1371 journal pone 0004210 PMC 2615218 PMID 19148289 Pakendorf Brigitte Novgorodov Innokentij N Osakovskij Vladimir L Danilova Al bina P Protod jakonov Artur P Stoneking Mark October 2006 Investigating the effects of prehistoric migrations in Siberia genetic variation and the origins of Yakuts Human Genetics 120 3 334 353 doi 10 1007 s00439 006 0213 2 PMID 16845541 S2CID 31651899 Atsushi Tajima et al March 2 2004 Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages Journal of Human Genetics 49 4 187 193 doi 10 1007 s10038 004 0131 x OCLC 110247689 PMID 14997363 Tanaka Masashi Cabrera Vicente M Gonzalez Ana M Larruga Jose M Takeyasu Takeshi Fuku Noriyuki Guo Li Jun Hirose Raita Fujita Yasunori Kurata Miyuki Shinoda Ken ichi Umetsu Kazuo Yamada Yoshiji Oshida Yoshiharu Sato Yuzo Hattori Nobutaka Mizuno Yoshikuni Arai Yasumichi Hirose Nobuyoshi Ohta Shigeo Ogawa Osamu Tanaka Yasushi Kawamori Ryuzo Shamoto Nagai Masayo Maruyama Wakako Shimokata Hiroshi Suzuki Ryota Shimodaira Hidetoshi October 2004 Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan Genome Research 14 10a 1832 1850 doi 10 1101 gr 2286304 PMC 524407 PMID 15466285 Trejaut Jean A Kivisild Toomas Loo Jun Hun Lee Chien Liang He Chun Lin Hsu Chia Jung Lee Zheng Yuan Lin Marie 2005 Traces of Archaic Mitochondrial Lineages Persist in Austronesian Speaking Formosan Populations PLOS Biology 3 8 e247 doi 10 1371 journal pbio 0030247 PMC 1166350 PMID 15984912 Umetsu Kazuo Tanaka Masashi Yuasa Isao et al 2005 Multiplex amplified product length polymorphism analysis of 36 mitochondrial single nucleotide polymorphisms for haplogrouping of East Asian populations Electrophoresis 26 1 91 98 doi 10 1002 elps 200406129 PMID 15624129 S2CID 44989190 External links editGeneral 47z TAT s blog Mannis van Oven s Phylotree Haplogroup M8 Ian Logan s Mitochondrial DNA Site Haplogroup M8 Retrieved from https en wikipedia org w index php title Haplogroup M8 amp oldid 1200987754, wikipedia, wiki, book, books, library,

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