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Wikipedia

Obesity

January 26, 2023

For the journal, see Obesity (journal).

Obesity is a medical condition, sometimes considered a disease,[8][9][10] in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's weight divided by the square of the person's height—is over 30 kg/m2; the range 25–30 kg/m2 is defined as overweight.[1] Some East Asian countries use lower values to calculate obesity.[11] Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis.[2][12][13]

Obesity
Silhouettes and waist circumferences representing optimal, overweight, and obese
SpecialtyEndocrinology
SymptomsIncreased fat[1]
ComplicationsCardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, osteoarthritis, depression[2][3]
CausesExcessive consumption of energy-dense foods, sedentary work and lifestyles and lack of physical activity, changes in modes of transportation, urbanization, lack of supportive policies, lack of access to a healthy diet, genetics[1][4]
Diagnostic methodBMI > 30 kg/m2[1]
PreventionSocietal changes, changes in the food industry, access to a healthy lifestyle, personal choices[1]
TreatmentDiet, exercise, medications, surgery[5][6]
PrognosisReduced life expectancy[2]
Frequency700 million / 12% (2015)[7]
Deaths2.8 million people per year

Obesity has individual, socioeconomic, and environmental causes. Some known causes are diet, physical activity, automation, urbanization, genetic susceptibility, medications, mental disorders, economic policies, endocrine disorders, and exposure to endocrine-disrupting chemicals.[1][4][14][15]

While a majority of obese individuals at any given time are attempting to lose weight and are often successful, maintaining weight loss long term is rare.[16] There is no effective, well-defined, evidence-based intervention for preventing obesity. Obesity prevention requires a complex approach, including interventions at societal, community, family, and individual levels.[1][13] Changes to diet and exercising are the main treatments recommended by health professionals.[2] Diet quality can be improved by reducing the consumption of energy-dense foods, such as those high in fat or sugars, and by increasing the intake of dietary fiber, if these dietary choices are available, affordable, and accessible.[1] Medications can be used, along with a suitable diet, to reduce appetite or decrease fat absorption.[5] If diet, exercise, and medication are not effective, a gastric balloon or surgery may be performed to reduce stomach volume or length of the intestines, leading to feeling full earlier, or a reduced ability to absorb nutrients from food.[6][17]

Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children.[18] In 2015, 600 million adults (12%) and 100 million children were obese in 195 countries.[7] Obesity is more common in women than in men.[1] Today, obesity is stigmatized in most of the world. Conversely, some cultures, past and present, have a favorable view of obesity, seeing it as a symbol of wealth and fertility.[2][19] Nevertheless, in 2013, several medical societies, including the American Medical Association and the American Heart Association, classified obesity as a disease.[20][21][22]

Classification

Main article: Classification of obesity
Category[23] BMI (kg/m2)
Underweight < 18.5
Normal weight 18.5 – 24.9
Overweight 25.0 – 29.9
Obese (class I) 30.0 – 34.9
Obese (class II) 35.0 – 39.9
Obese (class III) ≥ 40.0
 
A "super obese" male with a BMI of 53 kg/m2: weight 182 kg (401 lb), height 185 cm (6 ft 1 in). He presents with stretch marks and enlarged breasts.

Obesity is typically defined as a substantial accumulation of body fat that could impact health.[24] Medical organizations tend to classify people as obese based on body mass index (BMI) – a ratio of a person's weight in kilograms to the square of their height in meters. For adults, the World Health Organization (WHO) defines "overweight" as a BMI 25 or higher, and "obese" as a BMI 30 or higher.[24] The U.S. Centers for Disease Control and Prevention (CDC) further subdivides obesity based on BMI, with a BMI 30 to 35 called class 1 obesity; 35 to 40, class 2 obesity; and 40+, class 3 obesity.[25]

For children, obesity measures take age into consideration along with height and weight. For children aged 5–19, the WHO defines obesity as a BMI two standard deviations above the median for their age (a BMI around 18 for a five-year old; around 30 for a 19-year old).[24][26] For children under five, the WHO defines obesity as a weight three standard deviations above the median for their height.[24]

Some modifications to the WHO definitions have been made by particular organizations.[27] The surgical literature breaks down class II and III or only class III obesity into further categories whose exact values are still disputed.[28]

  • Any BMI ≥ 35 or 40 kg/m2 is severe obesity.
  • A BMI of ≥ 35 kg/m2 and experiencing obesity-related health conditions or ≥ 40 or 45 kg/m2 is morbid obesity.
  • A BMI of ≥ 45 or 50 kg/m2 is super obesity.

As Asian populations develop negative health consequences at a lower BMI than Caucasians, some nations have redefined obesity; Japan has defined obesity as any BMI greater than 25 kg/m2[11] while China uses a BMI of greater than 28 kg/m2.[27]

The preferred obesity metric in scholarly circles is the body fat percentage (BF%) – the ratio of the total weight of person's fat to his or her body weight, and BMI is viewed merely as a way to approximate BF%.[29] Levels in excess of 32% for women and 25% for men are generally considered to indicate obesity.

BMI ignores variations between individuals in amounts of lean body mass, particularly muscle mass. Individuals involved in heavy physical labor or sports may have high BMI values despite having little fat. For example, more than half of all NFL players are classified as "obese" (BMI ≥ 30), and 1 in 4 are classified as "extremely obese" (BMI ≥ 35), according to the BMI metric.[30] However, their mean body fat percentage, 14%, is well within what is considered a healthy range.[31] Similarly, Sumo wrestlers may be categorized by BMI as "severely obese" or "very severely obese" but many Sumo wrestlers are not categorized as obese when body fat percentage is used instead (having <25% body fat).[32] Some Sumo wrestlers were found to have no more body fat than a non-Sumo comparison group, with high BMI values resulting from their high amounts of lean body mass.[32]

Effects on health

Obesity increases a person's risk of developing various metabolic diseases, cardiovascular disease, osteoarthritis, Alzheimer disease, depression, and certain types of cancer.[33] Depending on the degree of obesity and the presence of comorbid disorders, obesity is associated with an estimated 2–20 year shorter life expectancy.[34][33] High BMI is a marker of risk for, but not a direct cause of, diseases caused by diet and physical activity.[13]

Mortality

Relative risk of death over 10 years in white people who have never smoked in the United States by BMI. The BMI range 22.5 to 24.9 is set as the reference.[35]

Obesity is one of the leading preventable causes of death worldwide.[36][37][38] The mortality risk is lowest at a BMI of 20–25 kg/m2[39][34][40] in non-smokers and at 24–27 kg/m2 in current smokers, with risk increasing along with changes in either direction.[41][42] This appears to apply in at least four continents.[40] Other research suggests that the association of BMI and waist circumference with mortality is U- or J-shaped, while the association between waist-to-hip ratio and waist-to-height ratio with mortality is more positive.[43] In Asians the risk of negative health effects begins to increase between 22 and 25 kg/m2.[44] In 2021, the World Health Organization estimated that obesity caused at least 2.8 million deaths annually.[45] On average, obesity reduces life expectancy by six to seven years,[2][46] a BMI of 30–35 kg/m2 reduces life expectancy by two to four years,[34] while severe obesity (BMI ≥ 40 kg/m2) reduces life expectancy by ten years.[34]

Morbidity

Main article: Obesity-associated morbidity

Obesity increases the risk of many physical and mental conditions. These comorbidities are most commonly shown in metabolic syndrome,[2] a combination of medical disorders which includes: diabetes mellitus type 2, high blood pressure, high blood cholesterol, and high triglyceride levels.[47] A study from the RAK Hospital found that obese people are at a greater risk of developing long COVID.[48] The CDC has found that obesity is the single strongest risk factor for severe COVID-19 illness.[49]

Complications are either directly caused by obesity or indirectly related through mechanisms sharing a common cause such as a poor diet or a sedentary lifestyle. The strength of the link between obesity and specific conditions varies. One of the strongest is the link with type 2 diabetes. Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women.[50]

Health consequences fall into two broad categories: those attributable to the effects of increased fat mass (such as osteoarthritis, obstructive sleep apnea, social stigmatization) and those due to the increased number of fat cells (diabetes, cancer, cardiovascular disease, non-alcoholic fatty liver disease).[2][51] Increases in body fat alter the body's response to insulin, potentially leading to insulin resistance. Increased fat also creates a proinflammatory state,[52][53] and a prothrombotic state.[51][54]

Medical field Condition Medical field Condition
Cardiology Dermatology
Endocrinology and reproductive medicine Gastroenterology
Neurology Oncology[68]
Psychiatry Respirology
Rheumatology and orthopedics Urology and Nephrology

Metrics of health

Main article: Metabolically healthy obesity

Newer research has focused on methods of identifying healthier obese people by clinicians, and not treating obese people as a monolithic group.[79] Obese people who do not experience medical complications from their obesity are sometimes called (metabolically) healthy obese, but the extent to which this group exists (especially among older people) is in dispute.[80] The number of people considered metabolically healthy depends on the definition used, and there is no universally accepted definition.[81] There are numerous obese people who have relatively few metabolic abnormalities, and a minority of obese people have no medical complications.[81] The guidelines of the American Association of Clinical Endocrinologists call for physicians to use risk stratification with obese patients when considering how to assess their risk of developing type 2 diabetes.[82]: 59–60 

In 2014, the BioSHaRE–EU Healthy Obese Project (sponsored by Maelstrom Research, a team under the Research Institute of the McGill University Health Centre) came up with two definitions for healthy obesity, one more strict and one less so:[80][83]

BioSHaRE Healthy Obese (HOP) Project Criteria (2014)
A patient must have a body mass index ≥ 30, and all of the following:
Less strict More strict
Blood pressure measured as follows, with no pharmaceutical help
Overall (mmHg) ≤ 140 ≤ 130
Systolic (mmHg) N/A ≤ 85
Diastolic (mmHg) ≤ 90 N/A
Blood sugar level measured as follows, with no pharmaceutical help
Blood glucose (mmol/l) ≤ 7.0 ≤ 6.1
Triglycerides measured as follows, with no pharmaceutical help
Fasting (mmol/L) ≤ 1.7
Non-fasting (mmol/L) ≤ 2.1
High-density lipoprotein measured as follows, with no pharmaceutical help
Men (mmol/L) > 1.03
Women (mmol/L) > 1.3
No diagnosis of any cardiovascular disease

To come up with these criteria, BioSHaRE controlled for age and tobacco use, researching how both may effect the metabolic syndrome associated with obesity, but not found to exist in the metabolically healthy obese.[84] Other definitions of metabolically healthy obesity exist, including ones based on waist circumference rather than BMI, which is unreliable in certain individuals.[81]

Another identification metric for health in obese people is calf strength, which is positively correlated with physical fitness in obese people.[85] Body composition in general is hypothesized to help explain the existence of metabolically healthy obesity—the metabolically healthy obese are often found to have low amounts of ectopic fat (fat stored in tissues other than adipose tissue) despite having overall fat mass equivalent in weight to obese people with metabolic syndrome.[86]: 1282 

Survival paradox

See also: Obesity paradox

Although the negative health consequences of obesity in the general population are well supported by the available research evidence, health outcomes in certain subgroups seem to be improved at an increased BMI, a phenomenon known as the obesity survival paradox.[87] The paradox was first described in 1999 in overweight and obese people undergoing hemodialysis,[87] and has subsequently been found in those with heart failure and peripheral artery disease (PAD).[88]

In people with heart failure, those with a BMI between 30.0 and 34.9 had lower mortality than those with a normal weight. This has been attributed to the fact that people often lose weight as they become progressively more ill.[89] Similar findings have been made in other types of heart disease. People with class I obesity and heart disease do not have greater rates of further heart problems than people of normal weight who also have heart disease. In people with greater degrees of obesity, however, the risk of further cardiovascular events is increased.[90][91] Even after cardiac bypass surgery, no increase in mortality is seen in the overweight and obese.[92] One study found that the improved survival could be explained by the more aggressive treatment obese people receive after a cardiac event.[93] Another study found that if one takes into account chronic obstructive pulmonary disease (COPD) in those with PAD, the benefit of obesity no longer exists.[88]

Causes

The "a calorie is a calorie" model of obesity posits a combination of excessive food energy intake and a lack of physical activity as the cause of most cases of obesity.[94] A limited number of cases are due primarily to genetics, medical reasons, or psychiatric illness.[15] In contrast, increasing rates of obesity at a societal level are felt to be due to an easily accessible and palatable diet,[95] increased reliance on cars, and mechanized manufacturing.[96][97]

Other possible contributors to the recent increase of obesity are: (1) insufficient sleep, (2) endocrine disruptors (environmental pollutants that interfere with lipid metabolism), (3) decreased variability in ambient temperature, (4) decreased rates of smoking, because smoking suppresses appetite, (5) increased use of medications that can cause weight gain (e.g., atypical antipsychotics), (6) proportional increases in ethnic and age groups that tend to be heavier, (7) pregnancy at a later age (which may cause susceptibility to obesity in children), (8) epigenetic risk factors passed on generationally, (9) natural selection for higher BMI, and (10) assortative mating leading to increased concentration of obesity risk factors (this would increase the number of obese people by increasing population variance in weight).[98] According to the Endocrine Society, there is "growing evidence suggesting that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight".[99] Societal pressure to diet as a means of maintaining or losing weight has also been suggested as a possible contributor.[100]

Diet

Main article: Diet and obesity
 
1961
 
2001–03
Map of dietary energy availability per person per day in 1961 (left) and 2001–2003 (right)[101] Calories per person per day (kilojoules per person per day)
 
Average per capita energy consumption of the world from 1961 to 2002[101]

Excess appetite for palatable, high-calorie food (especially fat, sugar, and certain animal proteins) is seen as the primary factor driving obesity worldwide, likely because of imbalances in neurotransmitters affecting the drive to eat.[102] Dietary energy supply per capita varies markedly between different regions and countries. It has also changed significantly over time.[101] From the early 1970s to the late 1990s the average food energy available per person per day (the amount of food bought) increased in all parts of the world except Eastern Europe. The United States had the highest availability with 3,654 calories (15,290 kJ) per person in 1996.[101] This increased further in 2003 to 3,754 calories (15,710 kJ).[101] During the late 1990s, Europeans had 3,394 calories (14,200 kJ) per person, in the developing areas of Asia there were 2,648 calories (11,080 kJ) per person, and in sub-Saharan Africa people had 2,176 calories (9,100 kJ) per person.[101][103] Total food energy consumption has been found to be related to obesity.[104]

The widespread availability of dietary guidelines[105] has done little to address the problems of overeating and poor dietary choice.[106] From 1971 to 2000, obesity rates in the United States increased from 14.5% to 30.9%.[107] During the same period, an increase occurred in the average amount of food energy consumed. For women, the average increase was 335 calories (1,400 kJ) per day (1,542 calories (6,450 kJ) in 1971 and 1,877 calories (7,850 kJ) in 2004), while for men the average increase was 168 calories (700 kJ) per day (2,450 calories (10,300 kJ) in 1971 and 2,618 calories (10,950 kJ) in 2004). Most of this extra food energy came from an increase in carbohydrate consumption rather than fat consumption.[108] The primary sources of these extra carbohydrates are sweetened beverages, which now account for almost 25 percent of daily food energy in young adults in America,[109] and potato chips.[110] Consumption of sweetened beverages such as soft drinks, fruit drinks, and iced tea is believed to be contributing to the rising rates of obesity[111][112] and to an increased risk of metabolic syndrome and type 2 diabetes.[113] Vitamin D deficiency is related to diseases associated with obesity.[114]

As societies become increasingly reliant on energy-dense, big-portions, and fast-food meals, the association between fast-food consumption and obesity becomes more concerning.[115] In the United States, consumption of fast-food meals tripled and food energy intake from these meals quadrupled between 1977 and 1995.[116]

Agricultural policy and techniques in the United States and Europe have led to lower food prices. In the United States, subsidization of corn, soy, wheat, and rice through the U.S. farm bill has made the main sources of processed food cheap compared to fruits and vegetables.[117] Calorie count laws and nutrition facts labels attempt to steer people toward making healthier food choices, including awareness of how much food energy is being consumed.

Obese people consistently under-report their food consumption as compared to people of normal weight.[118] This is supported both by tests of people carried out in a calorimeter room[119] and by direct observation.

Sedentary lifestyle

See also: Sedentary lifestyle and Exercise trends

A sedentary lifestyle may play a significant role in obesity.[120] Worldwide there has been a large shift towards less physically demanding work,[121][122][123] and currently at least 30% of the world's population gets insufficient exercise.[122] This is primarily due to increasing use of mechanized transportation and a greater prevalence of labor-saving technology in the home.[121][122][123] In children, there appear to be declines in levels of physical activity (with particularly strong declines in the amount of walking and physical education), likely due to safety concerns, changes in social interaction (such as fewer relationships with neighborhood children), and inadequate urban design (such as too few public spaces for safe physical activity).[124] World trends in active leisure time physical activity are less clear. The World Health Organization indicates people worldwide are taking up less active recreational pursuits, while research from Finland[125] found an increase and research from the United States found leisure-time physical activity has not changed significantly.[126] Physical activity in children may not be a significant contributor.[127]

In both children and adults, there is an association between television viewing time and the risk of obesity.[128][129][130] Increased media exposure increases the rate of childhood obesity, with rates increasing proportionally to time spent watching television.[131]

Genetics

Main article: Genetics of obesity
 
A 1680 painting by Juan Carreno de Miranda of a girl presumed to have Prader–Willi syndrome[132]

Like many other medical conditions, obesity is the result of an interplay between genetic and environmental factors.[133] Polymorphisms in various genes controlling appetite and metabolism predispose to obesity when sufficient food energy is present. As of 2006, more than 41 of these sites on the human genome have been linked to the development of obesity when a favorable environment is present.[134] People with two copies of the FTO gene (fat mass and obesity associated gene) have been found on average to weigh 3–4 kg more and have a 1.67-fold greater risk of obesity compared with those without the risk allele.[135] The differences in BMI between people that are due to genetics varies depending on the population examined from 6% to 85%.[136]

Obesity is a major feature in several syndromes, such as Prader–Willi syndrome, Bardet–Biedl syndrome, Cohen syndrome, and MOMO syndrome. (The term "non-syndromic obesity" is sometimes used to exclude these conditions.)[137] In people with early-onset severe obesity (defined by an onset before 10 years of age and body mass index over three standard deviations above normal), 7% harbor a single point DNA mutation.[138]

Studies that have focused on inheritance patterns rather than on specific genes have found that 80% of the offspring of two obese parents were also obese, in contrast to less than 10% of the offspring of two parents who were of normal weight.[139] Different people exposed to the same environment have different risks of obesity due to their underlying genetics.[140]

The thrifty gene hypothesis postulates that, due to dietary scarcity during human evolution, people are prone to obesity. Their ability to take advantage of rare periods of abundance by storing energy as fat would be advantageous during times of varying food availability, and individuals with greater adipose reserves would be more likely to survive famine. This tendency to store fat, however, would be maladaptive in societies with stable food supplies.[medical citation needed] This theory has received various criticisms, and other evolutionarily-based theories such as the drifty gene hypothesis and the thrifty phenotype hypothesis have also been proposed.[medical citation needed]

Other illnesses

Certain physical and mental illnesses and the pharmaceutical substances used to treat them can increase risk of obesity. Medical illnesses that increase obesity risk include several rare genetic syndromes (listed above) as well as some congenital or acquired conditions: hypothyroidism, Cushing's syndrome, growth hormone deficiency,[141] and some eating disorders such as binge eating disorder and night eating syndrome.[2] However, obesity is not regarded as a psychiatric disorder, and therefore is not listed in the DSM-IVR as a psychiatric illness.[142] The risk of overweight and obesity is higher in patients with psychiatric disorders than in persons without psychiatric disorders.[143] Obesity and depression influence each other mutually, with obesity increasing the risk of clinical depression, and also depression leading to a higher chance of developing obesity.[3]

Drug-induced obesity

Certain medications may cause weight gain or changes in body composition; these include insulin, sulfonylureas, thiazolidinediones, atypical antipsychotics, antidepressants, steroids, certain anticonvulsants (phenytoin and valproate), pizotifen, and some forms of hormonal contraception.[2]

Social determinants

Main article: Social determinants of obesity
 
The disease scroll (Yamai no soshi, late 12th century) depicts a woman moneylender with obesity, considered a disease of the rich.
 
Obesity in developed countries is correlated with economic inequality.

While genetic influences are important to understanding obesity, they cannot explain the current[when?] dramatic increase seen within specific countries or globally.[144][better source needed] Though it is accepted that energy consumption in excess of energy expenditure leads to increases in body weight on an individual basis, the cause of the shifts in these two factors on the societal scale is much debated. There are a number of theories as to the cause but most believe it is a combination of various factors.

The correlation between social class and BMI varies globally. Research in 1989 found that in developed countries women of a high social class were less likely to be obese. No significant differences were seen among men of different social classes. In the developing world, women, men, and children from high social classes had greater rates of obesity.[better source needed][145] In 2007 repeating the same research found the same relationships, but they were weaker. The decrease in strength of correlation was felt to be due to the effects of globalization.[146] Among developed countries, levels of adult obesity, and percentage of teenage children who are overweight, are correlated with income inequality. A similar relationship is seen among US states: more adults, even in higher social classes, are obese in more unequal states.[147]

Many explanations have been put forth for associations between BMI and social class. It is thought that in developed countries, the wealthy are able to afford more nutritious food, they are under greater social pressure to remain slim, and have more opportunities along with greater expectations for physical fitness. In undeveloped countries the ability to afford food, high energy expenditure with physical labor, and cultural values favoring a larger body size are believed to contribute to the observed patterns.[146] Attitudes toward body weight held by people in one's life may also play a role in obesity. A correlation in BMI changes over time has been found among friends, siblings, and spouses.[148] Stress and perceived low social status appear to increase risk of obesity.[147][149][150]

Smoking has a significant effect on an individual's weight. Those who quit smoking gain an average of 4.4 kilograms (9.7 lb) for men and 5.0 kilograms (11.0 lb) for women over ten years.[151] However, changing rates of smoking have had little effect on the overall rates of obesity.[152]

In the United States, the number of children a person has is related to their risk of obesity. A woman's risk increases by 7% per child, while a man's risk increases by 4% per child.[153] This could be partly explained by the fact that having dependent children decreases physical activity in Western parents.[154]

In the developing world urbanization is playing a role in increasing rate of obesity. In China overall rates of obesity are below 5%; however, in some cities rates of obesity are greater than 20%.[155] In part, this may be because of urban design issues (such as inadequate public spaces for physical activity).[124] Time spent in motor vehicles, as opposed to active transportation options such as cycling or walking, is correlated with increased risk of obesity.[156][157]

Malnutrition in early life is believed to play a role in the rising rates of obesity in the developing world.[158] Endocrine changes that occur during periods of malnutrition may promote the storage of fat once more food energy becomes available.[158]

Gut bacteria

See also: Infectobesity

The study of the effect of infectious agents on metabolism is still in its early stages. Gut flora has been shown to differ between lean and obese people. There is an indication that gut flora can affect the metabolic potential. This apparent alteration is believed to confer a greater capacity to harvest energy contributing to obesity. Whether these differences are the direct cause or the result of obesity has yet to be determined unequivocally.[159] The use of antibiotics among children has also been associated with obesity later in life.[160][161]

An association between viruses and obesity has been found in humans and several different animal species. The amount that these associations may have contributed to the rising rate of obesity is yet to be determined.[162]

Other factors

Not getting enough sleep is also associated with obesity.[163][164] Whether one causes the other is unclear.[163] Even if short sleep does increase weight gain it is unclear if this is to a meaningful degree or if increasing sleep would be of benefit.[165]

Some have proposed that chemical compounds called "obesogens" may play a role in obesity.

Certain aspects of personality are associated with being obese.[166] Loneliness,[167] neuroticism, impulsivity, and sensitivity to reward are more common in people who are obese while conscientiousness and self-control are less common in people who are obese.[166][168] Because most of the studies on this topic are questionnaire-based, it is possible that these findings overestimate the relationships between personality and obesity: people who are obese might be aware of the social stigma of obesity and their questionnaire responses might be biased accordingly.[166] Similarly, the personalities of people who are obese as children might be influenced by obesity stigma, rather than these personality factors acting as risk factors for obesity.[166]

Pathophysiology

Main article: Pathophysiology of obesity
 
A comparison of a mouse unable to produce leptin thus resulting in obesity (left) and a normal mouse (right)

Two distinct but related processes are considered to be involved in the development of obesity: sustained positive energy balance (energy intake exceeding energy expenditure) and the resetting of the body weight "set point" at an increased value.[169] The second process explains why finding effective obesity treatments has been difficult. While the underlying biology of this process still remains uncertain, research is beginning to clarify the mechanisms.[169]

At a biological level, there are many possible pathophysiological mechanisms involved in the development and maintenance of obesity.[170] This field of research had been almost unapproached until the leptin gene was discovered in 1994 by J. M. Friedman's laboratory.[171] While leptin and ghrelin are produced peripherally, they control appetite through their actions on the central nervous system. In particular, they and other appetite-related hormones act on the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. There are several circuits within the hypothalamus that contribute to its role in integrating appetite, the melanocortin pathway being the most well understood.[170] The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the brain's feeding and satiety centers, respectively.[172]

The arcuate nucleus contains two distinct groups of neurons.[170] The first group coexpresses neuropeptide Y (NPY) and agouti-related peptide (AgRP) and has stimulatory inputs to the LH and inhibitory inputs to the VMH. The second group coexpresses pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and has stimulatory inputs to the VMH and inhibitory inputs to the LH. Consequently, NPY/AgRP neurons stimulate feeding and inhibit satiety, while POMC/CART neurons stimulate satiety and inhibit feeding. Both groups of arcuate nucleus neurons are regulated in part by leptin. Leptin inhibits the NPY/AgRP group while stimulating the POMC/CART group. Thus a deficiency in leptin signaling, either via leptin deficiency or leptin resistance, leads to overfeeding and may account for some genetic and acquired forms of obesity.[170]

Management

Main article: Management of obesity

The main treatment for obesity consists of weight loss via lifestyle interventions, including prescribed diets and physical exercise.[20][94][173][174] Although it is unclear what diets might support long-term weight loss, and although the effectiveness of low-calorie diets is debated,[175] lifestyle changes that reduce calorie consumption or increase physical exercise over the long term also tend to produce some sustained weight loss, despite slow weight regain over time.[20][175][176][177] Although 87% of participants in the National Weight Control Registry were able to maintain 10% body weight loss for 10 years,[178][clarification needed] the most appropriate dietary approach for long term weight loss maintenance is still unknown.[179] In the US, intensive behavioral interventions combining both dietary changes and exercise are recommended.[20][173][180] Intermittent fasting has no additional benefit of weight loss compared to continuous energy restriction.[179] Adherence is a more important factor in weight loss success than whatever kind of diet an individual undertakes.[179][181]

Several hypo-caloric diets are effective.[20] In the short-term low carbohydrate diets appear better than low fat diets for weight loss.[182] In the long term, however, all types of low-carbohydrate and low-fat diets appear equally beneficial.[182][183] Heart disease and diabetes risks associated with different diets appear to be similar.[184] Promotion of the Mediterranean diets among the obese may lower the risk of heart disease.[182] Decreased intake of sweet drinks is also related to weight-loss.[182] Success rates of long-term weight loss maintenance with lifestyle changes are low, ranging from 2–20%.[185] Dietary and lifestyle changes are effective in limiting excessive weight gain in pregnancy and improve outcomes for both the mother and the child.[186] Intensive behavioral counseling is recommended in those who are both obese and have other risk factors for heart disease.[187]

Health policy

Obesity is a complex public health and policy problem because of its prevalence, costs, and health effects.[188] As such, managing it requires changes in the wider societal context and effort by communities, local authorities, and governments.[180] Public health efforts seek to understand and correct the environmental factors responsible for the increasing prevalence of obesity in the population. Solutions look at changing the factors that cause excess food energy consumption and inhibit physical activity. Efforts include federally reimbursed meal programs in schools, limiting direct junk food marketing to children,[189] and decreasing access to sugar-sweetened beverages in schools.[190] The World Health Organization recommends the taxing of sugary drinks.[191] When constructing urban environments, efforts have been made to increase access to parks and to develop pedestrian routes.[192]

Mass media campaigns seem to have limited effectiveness in changing behaviors that influence obesity, but may increase knowledge and awareness regarding physical activity and diet, which might lead to changes in the long term. Campaigns might also be able to reduce the amount of time spent sitting or lying down and positively affect the intention to be active physically.[193][194] Nutritional labelling with energy information on menus might be able to help reducing energy intake while dining in restaurants.[195]

Medical interventions

Medication

Main article: Anti-obesity medication

Since the introduction of medicines for the management of obesity in the 1930s, many compounds have been tried. Most of them reduce body weight by small amounts, and several of them are no longer marketed for obesity because of their side effects. Out of 25 anti-obesity medications withdrawn from the market between 1964 and 2009, 23 acted by altering the functions of chemical neurotransmitters in the brain. The most common side effects of these drugs that led to withdrawals were mental disturbances, cardiac side effects, and drug abuse or drug dependence. Deaths were reportedly associated with seven products.[196]

Five medications beneficial for long-term use are: orlistat, lorcaserin, liraglutide, phentermine–topiramate, and naltrexone–bupropion.[197] They result in weight loss after one year ranged from 3.0 to 6.7 kg (6.6-14.8 lbs) over placebo.[197] Orlistat, liraglutide, and naltrexone–bupropion are available in both the United States and Europe, phentermine–topiramate is available only in the United States.[198] European regulatory authorities rejected lorcaserin and phentermine-topiramate, in part because of associations of heart valve problems with lorcaserin and more general heart and blood vessel problems with phentermine–topiramate.[198] Lorcaserin was available in the United States and then removed from the market in 2020 due to its association with cancer.[199] Orlistat use is associated with high rates of gastrointestinal side effects[200] and concerns have been raised about negative effects on the kidneys.[201] There is no information on how these drugs affect longer-term complications of obesity such as cardiovascular disease or death,[5] however, liraglutide, when used for type 2 diabetes, does reduce cardiovascular events.[202]

In 2019 a systematic review compared the effects on weight of various doses of fluoxetine (60 mg/d, 40 mg/d, 20 mg/d, 10 mg/d) in obese adults.[203] When compared to placebo, all dosages of fluoxetine appeared to contribute to weight loss but lead to increased risk of experiencing side effects such as dizziness, drowsiness, fatigue, insomnia and nausea during period of treatment. However, these conclusions were from low certainty evidence.[203] When comparing, in the same review, the effects of fluoxetine on weight of obese adults, to other anti-obesity agents, omega-3 gel and not receiving a treatment, the authors could not reach conclusive results due to poor quality of evidence.[203]

Among antipsychotic drugs for treating schizophrenia clozapine is the most effective, but it also has the highest risk of causing the metabolic syndrome, of which obesity is the main feature. For people who gain weight because of clozapine, taking metformin may reportedly improve three of the five components of the metabolic syndrome: waist circumference, fasting glucose, and fasting triglycerides.[204]

Surgery

The most effective treatment for obesity is bariatric surgery.[6][20] The types of procedures include laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass, vertical-sleeve gastrectomy, and biliopancreatic diversion.[197] Surgery for severe obesity is associated with long-term weight loss, improvement in obesity-related conditions,[205] and decreased overall mortality, however, improved metabolic health results from the weight loss, not the surgery.[206] One study found a weight loss of between 14% and 25% (depending on the type of procedure performed) at 10 years, and a 29% reduction in all cause mortality when compared to standard weight loss measures.[207] Complications occur in about 17% of cases and reoperation is needed in 7% of cases.[205]

Epidemiology

Main article: Epidemiology of obesity
 
Share of adults with BMIs > 30 (2016)

See or edit source data.


In earlier historical periods obesity was rare, and achievable only by a small elite, although already recognised as a problem for health. But as prosperity increased in the Early Modern period, it affected increasingly larger groups of the population.[208] Prior to the 1970s, obesity was a relatively rare condition even in the wealthiest of nations, and when it did exist it tended to occur among the wealthy. Then, a confluence of events started to change the human condition. The average BMI of populations in first-world countries started to increase and, consequently, there was a rapid increase in the proportion of people overweight and obese.[209]

In 1997, the WHO formally recognized obesity as a global epidemic.[109] As of 2008, the WHO estimates that at least 500 million adults (greater than 10%) are obese, with higher rates among women than men.[210] The global prevalence of obesity more than doubled between 1980 and 2014. In 2014, more than 600 million adults were obese, equal to about 13 percent of the world's adult population.[211] The percentage of adults affected in the United States as of 2015–2016 is about 39.6% overall (37.9% of males and 41.1% of females).[212] In 2000, the World Health Organization (WHO) stated that overweight and obesity were replacing more traditional public health concerns such as undernutrition and infectious diseases as one of the most significant cause of poor health.[213]

The rate of obesity also increases with age at least up to 50 or 60 years old[214] and severe obesity in the United States, Australia, and Canada is increasing faster than the overall rate of obesity.[28][215][216] The OECD has projected an increase in obesity rates until at least 2030, especially in the United States, Mexico and England with rates reaching 47%, 39% and 35%, respectively.[217]

Once considered a problem only of high-income countries, obesity rates are rising worldwide and affecting both the developed and developing world.[218] These increases have been felt most dramatically in urban settings.[210]

Sex- and gender-based differences also influence the prevalence of obesity. Globally there are more obese women than men, but the numbers differ depending on how obesity is measured.[219][220]

History

Etymology

Obesity is from the Latin obesitas, which means "stout, fat, or plump". Ēsus is the past participle of edere (to eat), with ob (over) added to it.[221] The Oxford English Dictionary documents its first usage in 1611 by Randle Cotgrave.[222]

Historical attitudes

 
During the Middle Ages and the Renaissance obesity was often seen as a sign of wealth, and was relatively common among the elite: The Tuscan General Alessandro del Borro, attributed to Charles Mellin, 1645[223]
 
Venus of Willendorf created 24,000–22,000 BC

Ancient Greek medicine recognizes obesity as a medical disorder, and records that the Ancient Egyptians saw it in the same way.[208] Hippocrates wrote that "Corpulence is not only a disease itself, but the harbinger of others".[2] The Indian surgeon Sushruta (6th century BCE) related obesity to diabetes and heart disorders.[224] He recommended physical work to help cure it and its side effects.[224] For most of human history mankind struggled with food scarcity.[225] Obesity has thus historically been viewed as a sign of wealth and prosperity. It was common among high officials in Europe in the Middle Ages and the Renaissance[223] as well as in Ancient East Asian civilizations.[226] In the 17th century, English medical author Tobias Venner is credited with being one of the first to refer to the term as a societal disease in a published English language book.[208][227]

With the onset of the Industrial Revolution it was realized that the military and economic might of nations were dependent on both the body size and strength of their soldiers and workers.[109] Increasing the average body mass index from what is now considered underweight to what is now the normal range played a significant role in the development of industrialized societies.[109] Height and weight thus both increased through the 19th century in the developed world. During the 20th century, as populations reached their genetic potential for height, weight began increasing much more than height, resulting in obesity.[109] In the 1950s increasing wealth in the developed world decreased child mortality, but as body weight increased heart and kidney disease became more common.[109][228] During this time period, insurance companies realized the connection between weight and life expectancy and increased premiums for the obese.[2]

Many cultures throughout history have viewed obesity as the result of a character flaw. The obesus or fat character in Ancient Greek comedy was a glutton and figure of mockery. During Christian times the food was viewed as a gateway to the sins of sloth and lust.[19] In modern Western culture, excess weight is often regarded as unattractive, and obesity is commonly associated with various negative stereotypes. People of all ages can face social stigmatization, and may be targeted by bullies or shunned by their peers.[229]

Public perceptions in Western society regarding healthy body weight differ from those regarding the weight that is considered ideal  – and both have changed since the beginning of the 20th century. The weight that is viewed as an ideal has become lower since the 1920s. This is illustrated by the fact that the average height of Miss America pageant winners increased by 2% from 1922 to 1999, while their average weight decreased by 12%.[230] On the other hand, people's views concerning healthy weight have changed in the opposite direction. In Britain, the weight at which people considered themselves to be overweight was significantly higher in 2007 than in 1999.[231] These changes are believed to be due to increasing rates of adiposity leading to increased acceptance of extra body fat as being normal.[231]

Obesity is still seen as a sign of wealth and well-being in many parts of Africa. This has become particularly common since the HIV epidemic began.[2]

The arts

The first sculptural representations of the human body 20,000–35,000 years ago depict obese females. Some attribute the Venus figurines to the tendency to emphasize fertility while others feel they represent "fatness" in the people of the time.[19] Corpulence is, however, absent in both Greek and Roman art, probably in keeping with their ideals regarding moderation. This continued through much of Christian European history, with only those of low socioeconomic status being depicted as obese.[19]

During the Renaissance some of the upper class began flaunting their large size, as can be seen in portraits of Henry VIII of England and Alessandro dal Borro.[19] Rubens (1577–1640) regularly depicted heavyset women in his pictures, from which derives the term Rubenesque. These women, however, still maintained the "hourglass" shape with its relationship to fertility.[232] During the 19th century, views on obesity changed in the Western world. After centuries of obesity being synonymous with wealth and social status, slimness began to be seen as the desirable standard.[19] In his 1819 print, The Belle Alliance, or the Female Reformers of Blackburn!!!, artist George Cruikshank criticised the work of female reformers in Blackburn and used fatness as a means to portray them as unfeminine.[233]

Society and culture

Economic impact

In addition to its health impacts, obesity leads to many problems including disadvantages in employment[234][235] and increased business costs. These effects are felt by all levels of society from individuals, to corporations, to governments.

In 2005, the medical costs attributable to obesity in the US were an estimated $190.2 billion or 20.6% of all medical expenditures,[236][237][238] while the cost of obesity in Canada was estimated at CA$2 billion in 1997 (2.4% of total health costs).[94] The total annual direct cost of overweight and obesity in Australia in 2005 was A$21 billion. Overweight and obese Australians also received A$35.6 billion in government subsidies.[239] The estimate range for annual expenditures on diet products is $40 billion to $100 billion in the US alone.[240]

The Lancet Commission on Obesity in 2019 called for a global treaty—modelled on the WHO Framework Convention on Tobacco Control—committing countries to address obesity and undernutrition, explicitly excluding the food industry from policy development. They estimate the global cost of obesity $2 trillion a year, about or 2.8% of world GDP.[241]

Obesity prevention programs have been found to reduce the cost of treating obesity-related disease. However, the longer people live, the more medical costs they incur. Researchers, therefore, conclude that reducing obesity may improve the public's health, but it is unlikely to reduce overall health spending.[242] Sin taxes such as a sugary drink tax have been implemented in certain countries globally to curb dietary and consumer habits, and as an effort to offset the economic tolls.

 
Services accommodate obese people with specialized equipment such as much wider chairs.[243]

Obesity can lead to social stigmatization and disadvantages in employment.[234] When compared to their normal weight counterparts, obese workers on average have higher rates of absenteeism from work and take more disability leave, thus increasing costs for employers and decreasing productivity.[244] A study examining Duke University employees found that people with a BMI over 40 kg/m2 filed twice as many workers' compensation claims as those whose BMI was 18.5–24.9 kg/m2. They also had more than 12 times as many lost work days. The most common injuries in this group were due to falls and lifting, thus affecting the lower extremities, wrists or hands, and backs.[245] The Alabama State Employees' Insurance Board approved a controversial plan to charge obese workers $25 a month for health insurance that would otherwise be free unless they take steps to lose weight and improve their health. These measures started in January 2010 and apply to those state workers whose BMI exceeds 35 kg/m2 and who fail to make improvements in their health after one year.[246]

Some research shows that obese people are less likely to be hired for a job and are less likely to be promoted.[229] Obese people are also paid less than their non-obese counterparts for an equivalent job; obese women on average make 6% less and obese men make 3% less.[247]

Specific industries, such as the airline, healthcare and food industries, have special concerns. Due to rising rates of obesity, airlines face higher fuel costs and pressures to increase seating width.[248] In 2000, the extra weight of obese passengers cost airlines US$275 million.[249] The healthcare industry has had to invest in special facilities for handling severely obese patients, including special lifting equipment and bariatric ambulances.[250] Costs for restaurants are increased by litigation accusing them of causing obesity.[251] In 2005 the US Congress discussed legislation to prevent civil lawsuits against the food industry in relation to obesity; however, it did not become law.[251]

With the American Medical Association's 2013 classification of obesity as a chronic disease,[21] it is thought that health insurance companies will more likely pay for obesity treatment, counseling and surgery, and the cost of research and development of fat treatment pills or gene therapy treatments should be more affordable if insurers help to subsidize their cost.[252] The AMA classification is not legally binding, however, so health insurers still have the right to reject coverage for a treatment or procedure.[252]

In 2014, The European Court of Justice ruled that morbid obesity is a disability. The Court said that if an employee's obesity prevents them from "full and effective participation of that person in professional life on an equal basis with other workers", then it shall be considered a disability and that firing someone on such grounds is discriminatory.[253]

Size acceptance

See also: Fat acceptance movement, Social stigma of obesity, Health at Every Size, and Fat fetishism
 
United States President William Howard Taft was often ridiculed for being overweight.

The principal goal of the fat acceptance movement is to decrease discrimination against people who are overweight and obese.[254][255] However, some in the movement are also attempting to challenge the established relationship between obesity and negative health outcomes.[256]

A number of organizations exist that promote the acceptance of obesity. They have increased in prominence in the latter half of the 20th century.[257] The US-based National Association to Advance Fat Acceptance (NAAFA) was formed in 1969 and describes itself as a civil rights organization dedicated to ending size discrimination.[258]

The International Size Acceptance Association (ISAA) is a non-governmental organization (NGO) which was founded in 1997. It has more of a global orientation and describes its mission as promoting size acceptance and helping to end weight-based discrimination.[259] These groups often argue for the recognition of obesity as a disability under the US Americans With Disabilities Act (ADA). The American legal system, however, has decided that the potential public health costs exceed the benefits of extending this anti-discrimination law to cover obesity.[256]

Industry influence on research

In 2015, the New York Times published an article on the Global Energy Balance Network, a nonprofit founded in 2014 that advocated for people to focus on increasing exercise rather than reducing calorie intake to avoid obesity and to be healthy. The organization was founded with at least $1.5M in funding from the Coca-Cola Company, and the company has provided $4M in research funding to the two founding scientists Gregory A. Hand and Steven N. Blair since 2008.[260][261]

Reports

Many organizations have published reports pertaining to obesity. In 1998, the first US Federal guidelines were published, titled "Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report".[262] In 2006, the Canadian Obesity Network, now known as Obesity Canada published the "Canadian Clinical Practice Guidelines (CPG) on the Management and Prevention of Obesity in Adults and Children". This is a comprehensive evidence-based guideline to address the management and prevention of overweight and obesity in adults and children.[94]

In 2004, the United Kingdom Royal College of Physicians, the Faculty of Public Health and the Royal College of Paediatrics and Child Health released the report "Storing up Problems", which highlighted the growing problem of obesity in the UK.[263] The same year, the House of Commons Health Select Committee published its "most comprehensive inquiry [...] ever undertaken" into the impact of obesity on health and society in the UK and possible approaches to the problem.[264] In 2006, the National Institute for Health and Clinical Excellence (NICE) issued a guideline on the diagnosis and management of obesity, as well as policy implications for non-healthcare organizations such as local councils.[265] A 2007 report produced by Derek Wanless for the King's Fund warned that unless further action was taken, obesity had the capacity to debilitate the National Health Service financially.[266] In 2022 the National Institute for Health and Care Research (NIHR) published a comprehensive review of research on what local authorities can do to reduce obesity.[194]

The Obesity Policy Action (OPA) framework divides measure into upstream policies, midstream policies, and downstream policies. Upstream policies have to do with changing society, while midstream policies try to alter behaviors believed to contribute to obesity at the individual level, while downstream policies treat currently obese people.[267]

Childhood obesity

Main article: Childhood obesity

The healthy BMI range varies with the age and sex of the child. Obesity in children and adolescents is defined as a BMI greater than the 95th percentile.[268] The reference data that these percentiles are based on is from 1963 to 1994 and thus has not been affected by the recent increases in rates of obesity.[269] Childhood obesity has reached epidemic proportions in the 21st century, with rising rates in both the developed and the developing world. Rates of obesity in Canadian boys have increased from 11% in the 1980s to over 30% in the 1990s, while during this same time period rates increased from 4 to 14% in Brazilian children.[270] In the UK, there were 60% more obese children in 2005 compared to 1989.[271] In the US, the percentage of overweight and obese children increased to 16% in 2008, a 300% increase over the prior 30 years.[272]

As with obesity in adults, many factors contribute to the rising rates of childhood obesity. Changing diet and decreasing physical activity are believed to be the two most important causes for the recent increase in the incidence of child obesity.[273] Advertising of unhealthy foods to children also contributes, as it increases their consumption of the product.[274] Antibiotics in the first 6 months of life have been associated with excess weight at age seven to twelve years of age.[161] Because childhood obesity often persists into adulthood and is associated with numerous chronic illnesses, children who are obese are often tested for hypertension, diabetes, hyperlipidemia, and fatty liver disease.[94]

Treatments used in children are primarily lifestyle interventions and behavioral techniques, although efforts to increase activity in children have had little success.[275] In the United States, medications are not FDA approved for use in this age group.[270] Brief weight management interventions in primary care (e.g. delivered by a physician or nurse practitioner) have only a marginal positive effect in reducing childhood overweight or obesity.[276] Multi-component behaviour change interventions that include changes to dietary and physical activity may reduce BMI in the short term in children aged 6 to 11 years, although the benefits are small and quality of evidence is low.[277]

Other animals

Main article: Obesity in pets

Obesity in pets is common in many countries. In the United States, 23–41% of dogs are overweight, and about 5.1% are obese.[278] The rate of obesity in cats was slightly higher at 6.4%.[278] In Australia the rate of obesity among dogs in a veterinary setting has been found to be 7.6%.[279] The risk of obesity in dogs is related to whether or not their owners are obese; however, there is no similar correlation between cats and their owners.[280]

See also

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January 26, 2023
obesity, journal, journal, medical, condition, sometimes, considered, disease, which, excess, body, accumulated, such, extent, that, negatively, affect, health, people, classified, obese, when, their, body, mass, index, person, weight, divided, square, person,. For the journal see Obesity journal Obesity is a medical condition sometimes considered a disease 8 9 10 in which excess body fat has accumulated to such an extent that it may negatively affect health People are classified as obese when their body mass index BMI a person s weight divided by the square of the person s height is over 30 kg m2 the range 25 30 kg m2 is defined as overweight 1 Some East Asian countries use lower values to calculate obesity 11 Obesity is a major cause of disability and is correlated with various diseases and conditions particularly cardiovascular diseases type 2 diabetes obstructive sleep apnea certain types of cancer and osteoarthritis 2 12 13 ObesitySilhouettes and waist circumferences representing optimal overweight and obeseSpecialtyEndocrinologySymptomsIncreased fat 1 ComplicationsCardiovascular diseases type 2 diabetes obstructive sleep apnea certain types of cancer osteoarthritis depression 2 3 CausesExcessive consumption of energy dense foods sedentary work and lifestyles and lack of physical activity changes in modes of transportation urbanization lack of supportive policies lack of access to a healthy diet genetics 1 4 Diagnostic methodBMI gt 30 kg m2 1 PreventionSocietal changes changes in the food industry access to a healthy lifestyle personal choices 1 TreatmentDiet exercise medications surgery 5 6 PrognosisReduced life expectancy 2 Frequency700 million 12 2015 7 Deaths2 8 million people per yearObesity has individual socioeconomic and environmental causes Some known causes are diet physical activity automation urbanization genetic susceptibility medications mental disorders economic policies endocrine disorders and exposure to endocrine disrupting chemicals 1 4 14 15 While a majority of obese individuals at any given time are attempting to lose weight and are often successful maintaining weight loss long term is rare 16 There is no effective well defined evidence based intervention for preventing obesity Obesity prevention requires a complex approach including interventions at societal community family and individual levels 1 13 Changes to diet and exercising are the main treatments recommended by health professionals 2 Diet quality can be improved by reducing the consumption of energy dense foods such as those high in fat or sugars and by increasing the intake of dietary fiber if these dietary choices are available affordable and accessible 1 Medications can be used along with a suitable diet to reduce appetite or decrease fat absorption 5 If diet exercise and medication are not effective a gastric balloon or surgery may be performed to reduce stomach volume or length of the intestines leading to feeling full earlier or a reduced ability to absorb nutrients from food 6 17 Obesity is a leading preventable cause of death worldwide with increasing rates in adults and children 18 In 2015 600 million adults 12 and 100 million children were obese in 195 countries 7 Obesity is more common in women than in men 1 Today obesity is stigmatized in most of the world Conversely some cultures past and present have a favorable view of obesity seeing it as a symbol of wealth and fertility 2 19 Nevertheless in 2013 several medical societies including the American Medical Association and the American Heart Association classified obesity as a disease 20 21 22 Contents 1 Classification 2 Effects on health 2 1 Mortality 2 2 Morbidity 2 2 1 Metrics of health 2 3 Survival paradox 3 Causes 3 1 Diet 3 2 Sedentary lifestyle 3 3 Genetics 3 4 Other illnesses 3 5 Drug induced obesity 3 6 Social determinants 3 7 Gut bacteria 3 8 Other factors 4 Pathophysiology 5 Management 5 1 Health policy 6 Medical interventions 6 1 Medication 6 2 Surgery 7 Epidemiology 8 History 8 1 Etymology 8 2 Historical attitudes 8 3 The arts 9 Society and culture 9 1 Economic impact 9 2 Size acceptance 9 3 Industry influence on research 9 4 Reports 10 Childhood obesity 11 Other animals 12 See also 13 References 13 1 Citations 13 2 General and cited references 14 Further readingClassificationMain article Classification of obesity Category 23 BMI kg m2 Underweight lt 18 5Normal weight 18 5 24 9Overweight 25 0 29 9Obese class I 30 0 34 9Obese class II 35 0 39 9Obese class III 40 0 A super obese male with a BMI of 53 kg m2 weight 182 kg 401 lb height 185 cm 6 ft 1 in He presents with stretch marks and enlarged breasts Obesity is typically defined as a substantial accumulation of body fat that could impact health 24 Medical organizations tend to classify people as obese based on body mass index BMI a ratio of a person s weight in kilograms to the square of their height in meters For adults the World Health Organization WHO defines overweight as a BMI 25 or higher and obese as a BMI 30 or higher 24 The U S Centers for Disease Control and Prevention CDC further subdivides obesity based on BMI with a BMI 30 to 35 called class 1 obesity 35 to 40 class 2 obesity and 40 class 3 obesity 25 For children obesity measures take age into consideration along with height and weight For children aged 5 19 the WHO defines obesity as a BMI two standard deviations above the median for their age a BMI around 18 for a five year old around 30 for a 19 year old 24 26 For children under five the WHO defines obesity as a weight three standard deviations above the median for their height 24 Some modifications to the WHO definitions have been made by particular organizations 27 The surgical literature breaks down class II and III or only class III obesity into further categories whose exact values are still disputed 28 Any BMI 35 or 40 kg m2 is severe obesity A BMI of 35 kg m2 and experiencing obesity related health conditions or 40 or 45 kg m2 is morbid obesity A BMI of 45 or 50 kg m2 is super obesity As Asian populations develop negative health consequences at a lower BMI than Caucasians some nations have redefined obesity Japan has defined obesity as any BMI greater than 25 kg m2 11 while China uses a BMI of greater than 28 kg m2 27 The preferred obesity metric in scholarly circles is the body fat percentage BF the ratio of the total weight of person s fat to his or her body weight and BMI is viewed merely as a way to approximate BF 29 Levels in excess of 32 for women and 25 for men are generally considered to indicate obesity BMI ignores variations between individuals in amounts of lean body mass particularly muscle mass Individuals involved in heavy physical labor or sports may have high BMI values despite having little fat For example more than half of all NFL players are classified as obese BMI 30 and 1 in 4 are classified as extremely obese BMI 35 according to the BMI metric 30 However their mean body fat percentage 14 is well within what is considered a healthy range 31 Similarly Sumo wrestlers may be categorized by BMI as severely obese or very severely obese but many Sumo wrestlers are not categorized as obese when body fat percentage is used instead having lt 25 body fat 32 Some Sumo wrestlers were found to have no more body fat than a non Sumo comparison group with high BMI values resulting from their high amounts of lean body mass 32 Effects on healthObesity increases a person s risk of developing various metabolic diseases cardiovascular disease osteoarthritis Alzheimer disease depression and certain types of cancer 33 Depending on the degree of obesity and the presence of comorbid disorders obesity is associated with an estimated 2 20 year shorter life expectancy 34 33 High BMI is a marker of risk for but not a direct cause of diseases caused by diet and physical activity 13 Mortality Relative risk of death over 10 years in white people who have never smoked in the United States by BMI The BMI range 22 5 to 24 9 is set as the reference 35 Obesity is one of the leading preventable causes of death worldwide 36 37 38 The mortality risk is lowest at a BMI of 20 25 kg m2 39 34 40 in non smokers and at 24 27 kg m2 in current smokers with risk increasing along with changes in either direction 41 42 This appears to apply in at least four continents 40 Other research suggests that the association of BMI and waist circumference with mortality is U or J shaped while the association between waist to hip ratio and waist to height ratio with mortality is more positive 43 In Asians the risk of negative health effects begins to increase between 22 and 25 kg m2 44 In 2021 the World Health Organization estimated that obesity caused at least 2 8 million deaths annually 45 On average obesity reduces life expectancy by six to seven years 2 46 a BMI of 30 35 kg m2 reduces life expectancy by two to four years 34 while severe obesity BMI 40 kg m2 reduces life expectancy by ten years 34 Morbidity Main article Obesity associated morbidity Obesity increases the risk of many physical and mental conditions These comorbidities are most commonly shown in metabolic syndrome 2 a combination of medical disorders which includes diabetes mellitus type 2 high blood pressure high blood cholesterol and high triglyceride levels 47 A study from the RAK Hospital found that obese people are at a greater risk of developing long COVID 48 The CDC has found that obesity is the single strongest risk factor for severe COVID 19 illness 49 Complications are either directly caused by obesity or indirectly related through mechanisms sharing a common cause such as a poor diet or a sedentary lifestyle The strength of the link between obesity and specific conditions varies One of the strongest is the link with type 2 diabetes Excess body fat underlies 64 of cases of diabetes in men and 77 of cases in women 50 Health consequences fall into two broad categories those attributable to the effects of increased fat mass such as osteoarthritis obstructive sleep apnea social stigmatization and those due to the increased number of fat cells diabetes cancer cardiovascular disease non alcoholic fatty liver disease 2 51 Increases in body fat alter the body s response to insulin potentially leading to insulin resistance Increased fat also creates a proinflammatory state 52 53 and a prothrombotic state 51 54 Parts of this article those related to table below need to be updated Please help update this article to reflect recent events or newly available information March 2022 Medical field Condition Medical field ConditionCardiology Coronary heart disease 55 angina and myocardial infarction Congestive heart failure 2 56 High blood pressure 2 Abnormal cholesterol levels 2 Deep vein thrombosis and pulmonary embolism 57 Dermatology Acanthosis nigricans 58 Lymphedema 58 Cellulitis 58 Hirsutism 58 Intertrigo 59 Endocrinology and reproductive medicine Diabetes mellitus 2 Polycystic ovarian syndrome 2 Menstrual disorders 2 Infertility 2 60 Complications during pregnancy 2 60 Birth defects 2 Intrauterine fetal death 60 Gastroenterology Gastroesophageal reflux disease 61 Fatty liver disease 61 Cholelithiasis gallstones 61 Neurology Stroke 2 Meralgia paresthetica 62 Migraines 63 Carpal tunnel syndrome 64 Dementia 65 Idiopathic intracranial hypertension 66 Multiple sclerosis 67 Oncology 68 Esophageal Colorectal Pancreatic Gallbladder Endometrial Kidney Leukemia Hepatocellular carcinoma 61 Malignant melanomaPsychiatry Depression in women 2 Social stigmatization 2 Respirology Obstructive sleep apnea 2 69 Obesity hypoventilation syndrome 2 69 Asthma 2 69 Increased complications during general anaesthesia 2 increased risk of severe COVID 19 70 Rheumatology and orthopedics Gout 71 Poor mobility 72 Osteoarthritis 2 Low back pain 73 Urology and Nephrology Erectile dysfunction 74 Urinary incontinence 75 Chronic renal failure 76 Hypogonadism 77 Buried penis 78 Metrics of health Main article Metabolically healthy obesity Newer research has focused on methods of identifying healthier obese people by clinicians and not treating obese people as a monolithic group 79 Obese people who do not experience medical complications from their obesity are sometimes called metabolically healthy obese but the extent to which this group exists especially among older people is in dispute 80 The number of people considered metabolically healthy depends on the definition used and there is no universally accepted definition 81 There are numerous obese people who have relatively few metabolic abnormalities and a minority of obese people have no medical complications 81 The guidelines of the American Association of Clinical Endocrinologists call for physicians to use risk stratification with obese patients when considering how to assess their risk of developing type 2 diabetes 82 59 60 In 2014 the BioSHaRE EU Healthy Obese Project sponsored by Maelstrom Research a team under the Research Institute of the McGill University Health Centre came up with two definitions for healthy obesity one more strict and one less so 80 83 BioSHaRE Healthy Obese HOP Project Criteria 2014 A patient must have a body mass index 30 and all of the following Less strict More strictBlood pressure measured as follows with no pharmaceutical helpOverall mmHg 140 130Systolic mmHg N A 85Diastolic mmHg 90 N ABlood sugar level measured as follows with no pharmaceutical helpBlood glucose mmol l 7 0 6 1Triglycerides measured as follows with no pharmaceutical helpFasting mmol L 1 7Non fasting mmol L 2 1High density lipoprotein measured as follows with no pharmaceutical helpMen mmol L gt 1 03Women mmol L gt 1 3No diagnosis of any cardiovascular diseaseTo come up with these criteria BioSHaRE controlled for age and tobacco use researching how both may effect the metabolic syndrome associated with obesity but not found to exist in the metabolically healthy obese 84 Other definitions of metabolically healthy obesity exist including ones based on waist circumference rather than BMI which is unreliable in certain individuals 81 Another identification metric for health in obese people is calf strength which is positively correlated with physical fitness in obese people 85 Body composition in general is hypothesized to help explain the existence of metabolically healthy obesity the metabolically healthy obese are often found to have low amounts of ectopic fat fat stored in tissues other than adipose tissue despite having overall fat mass equivalent in weight to obese people with metabolic syndrome 86 1282 Survival paradox See also Obesity paradox Although the negative health consequences of obesity in the general population are well supported by the available research evidence health outcomes in certain subgroups seem to be improved at an increased BMI a phenomenon known as the obesity survival paradox 87 The paradox was first described in 1999 in overweight and obese people undergoing hemodialysis 87 and has subsequently been found in those with heart failure and peripheral artery disease PAD 88 In people with heart failure those with a BMI between 30 0 and 34 9 had lower mortality than those with a normal weight This has been attributed to the fact that people often lose weight as they become progressively more ill 89 Similar findings have been made in other types of heart disease People with class I obesity and heart disease do not have greater rates of further heart problems than people of normal weight who also have heart disease In people with greater degrees of obesity however the risk of further cardiovascular events is increased 90 91 Even after cardiac bypass surgery no increase in mortality is seen in the overweight and obese 92 One study found that the improved survival could be explained by the more aggressive treatment obese people receive after a cardiac event 93 Another study found that if one takes into account chronic obstructive pulmonary disease COPD in those with PAD the benefit of obesity no longer exists 88 CausesThe a calorie is a calorie model of obesity posits a combination of excessive food energy intake and a lack of physical activity as the cause of most cases of obesity 94 A limited number of cases are due primarily to genetics medical reasons or psychiatric illness 15 In contrast increasing rates of obesity at a societal level are felt to be due to an easily accessible and palatable diet 95 increased reliance on cars and mechanized manufacturing 96 97 Other possible contributors to the recent increase of obesity are 1 insufficient sleep 2 endocrine disruptors environmental pollutants that interfere with lipid metabolism 3 decreased variability in ambient temperature 4 decreased rates of smoking because smoking suppresses appetite 5 increased use of medications that can cause weight gain e g atypical antipsychotics 6 proportional increases in ethnic and age groups that tend to be heavier 7 pregnancy at a later age which may cause susceptibility to obesity in children 8 epigenetic risk factors passed on generationally 9 natural selection for higher BMI and 10 assortative mating leading to increased concentration of obesity risk factors this would increase the number of obese people by increasing population variance in weight 98 According to the Endocrine Society there is growing evidence suggesting that obesity is a disorder of the energy homeostasis system rather than simply arising from the passive accumulation of excess weight 99 Societal pressure to diet as a means of maintaining or losing weight has also been suggested as a possible contributor 100 Diet Main article Diet and obesity 1961 2001 03Map of dietary energy availability per person per day in 1961 left and 2001 2003 right 101 Calories per person per day kilojoules per person per day No data lt 1 600 lt 6 700 1 600 1 800 6 700 7 500 1 800 2 000 7 500 8 400 2 000 2 200 8 400 9 200 2 200 2 400 9 200 10 000 2 400 2 600 10 000 10 900 2 600 2 800 10 900 11 700 2 800 3 000 11 700 12 600 3 000 3 200 12 600 13 400 3 200 3 400 13 400 14 200 3 400 3 600 14 200 15 100 gt 3 600 gt 15 100 Average per capita energy consumption of the world from 1961 to 2002 101 Excess appetite for palatable high calorie food especially fat sugar and certain animal proteins is seen as the primary factor driving obesity worldwide likely because of imbalances in neurotransmitters affecting the drive to eat 102 Dietary energy supply per capita varies markedly between different regions and countries It has also changed significantly over time 101 From the early 1970s to the late 1990s the average food energy available per person per day the amount of food bought increased in all parts of the world except Eastern Europe The United States had the highest availability with 3 654 calories 15 290 kJ per person in 1996 101 This increased further in 2003 to 3 754 calories 15 710 kJ 101 During the late 1990s Europeans had 3 394 calories 14 200 kJ per person in the developing areas of Asia there were 2 648 calories 11 080 kJ per person and in sub Saharan Africa people had 2 176 calories 9 100 kJ per person 101 103 Total food energy consumption has been found to be related to obesity 104 The widespread availability of dietary guidelines 105 has done little to address the problems of overeating and poor dietary choice 106 From 1971 to 2000 obesity rates in the United States increased from 14 5 to 30 9 107 During the same period an increase occurred in the average amount of food energy consumed For women the average increase was 335 calories 1 400 kJ per day 1 542 calories 6 450 kJ in 1971 and 1 877 calories 7 850 kJ in 2004 while for men the average increase was 168 calories 700 kJ per day 2 450 calories 10 300 kJ in 1971 and 2 618 calories 10 950 kJ in 2004 Most of this extra food energy came from an increase in carbohydrate consumption rather than fat consumption 108 The primary sources of these extra carbohydrates are sweetened beverages which now account for almost 25 percent of daily food energy in young adults in America 109 and potato chips 110 Consumption of sweetened beverages such as soft drinks fruit drinks and iced tea is believed to be contributing to the rising rates of obesity 111 112 and to an increased risk of metabolic syndrome and type 2 diabetes 113 Vitamin D deficiency is related to diseases associated with obesity 114 As societies become increasingly reliant on energy dense big portions and fast food meals the association between fast food consumption and obesity becomes more concerning 115 In the United States consumption of fast food meals tripled and food energy intake from these meals quadrupled between 1977 and 1995 116 Agricultural policy and techniques in the United States and Europe have led to lower food prices In the United States subsidization of corn soy wheat and rice through the U S farm bill has made the main sources of processed food cheap compared to fruits and vegetables 117 Calorie count laws and nutrition facts labels attempt to steer people toward making healthier food choices including awareness of how much food energy is being consumed Obese people consistently under report their food consumption as compared to people of normal weight 118 This is supported both by tests of people carried out in a calorimeter room 119 and by direct observation Sedentary lifestyle See also Sedentary lifestyle and Exercise trends A sedentary lifestyle may play a significant role in obesity 120 Worldwide there has been a large shift towards less physically demanding work 121 122 123 and currently at least 30 of the world s population gets insufficient exercise 122 This is primarily due to increasing use of mechanized transportation and a greater prevalence of labor saving technology in the home 121 122 123 In children there appear to be declines in levels of physical activity with particularly strong declines in the amount of walking and physical education likely due to safety concerns changes in social interaction such as fewer relationships with neighborhood children and inadequate urban design such as too few public spaces for safe physical activity 124 World trends in active leisure time physical activity are less clear The World Health Organization indicates people worldwide are taking up less active recreational pursuits while research from Finland 125 found an increase and research from the United States found leisure time physical activity has not changed significantly 126 Physical activity in children may not be a significant contributor 127 In both children and adults there is an association between television viewing time and the risk of obesity 128 129 130 Increased media exposure increases the rate of childhood obesity with rates increasing proportionally to time spent watching television 131 Genetics Main article Genetics of obesity This section needs to be updated Please help update this article to reflect recent events or newly available information July 2021 A 1680 painting by Juan Carreno de Miranda of a girl presumed to have Prader Willi syndrome 132 Like many other medical conditions obesity is the result of an interplay between genetic and environmental factors 133 Polymorphisms in various genes controlling appetite and metabolism predispose to obesity when sufficient food energy is present As of 2006 more than 41 of these sites on the human genome have been linked to the development of obesity when a favorable environment is present 134 People with two copies of the FTO gene fat mass and obesity associated gene have been found on average to weigh 3 4 kg more and have a 1 67 fold greater risk of obesity compared with those without the risk allele 135 The differences in BMI between people that are due to genetics varies depending on the population examined from 6 to 85 136 Obesity is a major feature in several syndromes such as Prader Willi syndrome Bardet Biedl syndrome Cohen syndrome and MOMO syndrome The term non syndromic obesity is sometimes used to exclude these conditions 137 In people with early onset severe obesity defined by an onset before 10 years of age and body mass index over three standard deviations above normal 7 harbor a single point DNA mutation 138 Studies that have focused on inheritance patterns rather than on specific genes have found that 80 of the offspring of two obese parents were also obese in contrast to less than 10 of the offspring of two parents who were of normal weight 139 Different people exposed to the same environment have different risks of obesity due to their underlying genetics 140 The thrifty gene hypothesis postulates that due to dietary scarcity during human evolution people are prone to obesity Their ability to take advantage of rare periods of abundance by storing energy as fat would be advantageous during times of varying food availability and individuals with greater adipose reserves would be more likely to survive famine This tendency to store fat however would be maladaptive in societies with stable food supplies medical citation needed This theory has received various criticisms and other evolutionarily based theories such as the drifty gene hypothesis and the thrifty phenotype hypothesis have also been proposed medical citation needed Other illnesses Certain physical and mental illnesses and the pharmaceutical substances used to treat them can increase risk of obesity Medical illnesses that increase obesity risk include several rare genetic syndromes listed above as well as some congenital or acquired conditions hypothyroidism Cushing s syndrome growth hormone deficiency 141 and some eating disorders such as binge eating disorder and night eating syndrome 2 However obesity is not regarded as a psychiatric disorder and therefore is not listed in the DSM IVR as a psychiatric illness 142 The risk of overweight and obesity is higher in patients with psychiatric disorders than in persons without psychiatric disorders 143 Obesity and depression influence each other mutually with obesity increasing the risk of clinical depression and also depression leading to a higher chance of developing obesity 3 Drug induced obesity Certain medications may cause weight gain or changes in body composition these include insulin sulfonylureas thiazolidinediones atypical antipsychotics antidepressants steroids certain anticonvulsants phenytoin and valproate pizotifen and some forms of hormonal contraception 2 Social determinants Main article Social determinants of obesity The disease scroll Yamai no soshi late 12th century depicts a woman moneylender with obesity considered a disease of the rich Obesity in developed countries is correlated with economic inequality While genetic influences are important to understanding obesity they cannot explain the current when dramatic increase seen within specific countries or globally 144 better source needed Though it is accepted that energy consumption in excess of energy expenditure leads to increases in body weight on an individual basis the cause of the shifts in these two factors on the societal scale is much debated There are a number of theories as to the cause but most believe it is a combination of various factors The correlation between social class and BMI varies globally Research in 1989 found that in developed countries women of a high social class were less likely to be obese No significant differences were seen among men of different social classes In the developing world women men and children from high social classes had greater rates of obesity better source needed 145 In 2007 repeating the same research found the same relationships but they were weaker The decrease in strength of correlation was felt to be due to the effects of globalization 146 Among developed countries levels of adult obesity and percentage of teenage children who are overweight are correlated with income inequality A similar relationship is seen among US states more adults even in higher social classes are obese in more unequal states 147 Many explanations have been put forth for associations between BMI and social class It is thought that in developed countries the wealthy are able to afford more nutritious food they are under greater social pressure to remain slim and have more opportunities along with greater expectations for physical fitness In undeveloped countries the ability to afford food high energy expenditure with physical labor and cultural values favoring a larger body size are believed to contribute to the observed patterns 146 Attitudes toward body weight held by people in one s life may also play a role in obesity A correlation in BMI changes over time has been found among friends siblings and spouses 148 Stress and perceived low social status appear to increase risk of obesity 147 149 150 Smoking has a significant effect on an individual s weight Those who quit smoking gain an average of 4 4 kilograms 9 7 lb for men and 5 0 kilograms 11 0 lb for women over ten years 151 However changing rates of smoking have had little effect on the overall rates of obesity 152 In the United States the number of children a person has is related to their risk of obesity A woman s risk increases by 7 per child while a man s risk increases by 4 per child 153 This could be partly explained by the fact that having dependent children decreases physical activity in Western parents 154 In the developing world urbanization is playing a role in increasing rate of obesity In China overall rates of obesity are below 5 however in some cities rates of obesity are greater than 20 155 In part this may be because of urban design issues such as inadequate public spaces for physical activity 124 Time spent in motor vehicles as opposed to active transportation options such as cycling or walking is correlated with increased risk of obesity 156 157 Malnutrition in early life is believed to play a role in the rising rates of obesity in the developing world 158 Endocrine changes that occur during periods of malnutrition may promote the storage of fat once more food energy becomes available 158 Gut bacteria See also Infectobesity The study of the effect of infectious agents on metabolism is still in its early stages Gut flora has been shown to differ between lean and obese people There is an indication that gut flora can affect the metabolic potential This apparent alteration is believed to confer a greater capacity to harvest energy contributing to obesity Whether these differences are the direct cause or the result of obesity has yet to be determined unequivocally 159 The use of antibiotics among children has also been associated with obesity later in life 160 161 An association between viruses and obesity has been found in humans and several different animal species The amount that these associations may have contributed to the rising rate of obesity is yet to be determined 162 Other factors Not getting enough sleep is also associated with obesity 163 164 Whether one causes the other is unclear 163 Even if short sleep does increase weight gain it is unclear if this is to a meaningful degree or if increasing sleep would be of benefit 165 Some have proposed that chemical compounds called obesogens may play a role in obesity Certain aspects of personality are associated with being obese 166 Loneliness 167 neuroticism impulsivity and sensitivity to reward are more common in people who are obese while conscientiousness and self control are less common in people who are obese 166 168 Because most of the studies on this topic are questionnaire based it is possible that these findings overestimate the relationships between personality and obesity people who are obese might be aware of the social stigma of obesity and their questionnaire responses might be biased accordingly 166 Similarly the personalities of people who are obese as children might be influenced by obesity stigma rather than these personality factors acting as risk factors for obesity 166 PathophysiologyMain article Pathophysiology of obesity A comparison of a mouse unable to produce leptin thus resulting in obesity left and a normal mouse right Two distinct but related processes are considered to be involved in the development of obesity sustained positive energy balance energy intake exceeding energy expenditure and the resetting of the body weight set point at an increased value 169 The second process explains why finding effective obesity treatments has been difficult While the underlying biology of this process still remains uncertain research is beginning to clarify the mechanisms 169 At a biological level there are many possible pathophysiological mechanisms involved in the development and maintenance of obesity 170 This field of research had been almost unapproached until the leptin gene was discovered in 1994 by J M Friedman s laboratory 171 While leptin and ghrelin are produced peripherally they control appetite through their actions on the central nervous system In particular they and other appetite related hormones act on the hypothalamus a region of the brain central to the regulation of food intake and energy expenditure There are several circuits within the hypothalamus that contribute to its role in integrating appetite the melanocortin pathway being the most well understood 170 The circuit begins with an area of the hypothalamus the arcuate nucleus that has outputs to the lateral hypothalamus LH and ventromedial hypothalamus VMH the brain s feeding and satiety centers respectively 172 The arcuate nucleus contains two distinct groups of neurons 170 The first group coexpresses neuropeptide Y NPY and agouti related peptide AgRP and has stimulatory inputs to the LH and inhibitory inputs to the VMH The second group coexpresses pro opiomelanocortin POMC and cocaine and amphetamine regulated transcript CART and has stimulatory inputs to the VMH and inhibitory inputs to the LH Consequently NPY AgRP neurons stimulate feeding and inhibit satiety while POMC CART neurons stimulate satiety and inhibit feeding Both groups of arcuate nucleus neurons are regulated in part by leptin Leptin inhibits the NPY AgRP group while stimulating the POMC CART group Thus a deficiency in leptin signaling either via leptin deficiency or leptin resistance leads to overfeeding and may account for some genetic and acquired forms of obesity 170 ManagementMain article Management of obesity The main treatment for obesity consists of weight loss via lifestyle interventions including prescribed diets and physical exercise 20 94 173 174 Although it is unclear what diets might support long term weight loss and although the effectiveness of low calorie diets is debated 175 lifestyle changes that reduce calorie consumption or increase physical exercise over the long term also tend to produce some sustained weight loss despite slow weight regain over time 20 175 176 177 Although 87 of participants in the National Weight Control Registry were able to maintain 10 body weight loss for 10 years 178 clarification needed the most appropriate dietary approach for long term weight loss maintenance is still unknown 179 In the US intensive behavioral interventions combining both dietary changes and exercise are recommended 20 173 180 Intermittent fasting has no additional benefit of weight loss compared to continuous energy restriction 179 Adherence is a more important factor in weight loss success than whatever kind of diet an individual undertakes 179 181 Several hypo caloric diets are effective 20 In the short term low carbohydrate diets appear better than low fat diets for weight loss 182 In the long term however all types of low carbohydrate and low fat diets appear equally beneficial 182 183 Heart disease and diabetes risks associated with different diets appear to be similar 184 Promotion of the Mediterranean diets among the obese may lower the risk of heart disease 182 Decreased intake of sweet drinks is also related to weight loss 182 Success rates of long term weight loss maintenance with lifestyle changes are low ranging from 2 20 185 Dietary and lifestyle changes are effective in limiting excessive weight gain in pregnancy and improve outcomes for both the mother and the child 186 Intensive behavioral counseling is recommended in those who are both obese and have other risk factors for heart disease 187 Health policy Obesity is a complex public health and policy problem because of its prevalence costs and health effects 188 As such managing it requires changes in the wider societal context and effort by communities local authorities and governments 180 Public health efforts seek to understand and correct the environmental factors responsible for the increasing prevalence of obesity in the population Solutions look at changing the factors that cause excess food energy consumption and inhibit physical activity Efforts include federally reimbursed meal programs in schools limiting direct junk food marketing to children 189 and decreasing access to sugar sweetened beverages in schools 190 The World Health Organization recommends the taxing of sugary drinks 191 When constructing urban environments efforts have been made to increase access to parks and to develop pedestrian routes 192 Mass media campaigns seem to have limited effectiveness in changing behaviors that influence obesity but may increase knowledge and awareness regarding physical activity and diet which might lead to changes in the long term Campaigns might also be able to reduce the amount of time spent sitting or lying down and positively affect the intention to be active physically 193 194 Nutritional labelling with energy information on menus might be able to help reducing energy intake while dining in restaurants 195 Medical interventionsMedication Main article Anti obesity medication Since the introduction of medicines for the management of obesity in the 1930s many compounds have been tried Most of them reduce body weight by small amounts and several of them are no longer marketed for obesity because of their side effects Out of 25 anti obesity medications withdrawn from the market between 1964 and 2009 23 acted by altering the functions of chemical neurotransmitters in the brain The most common side effects of these drugs that led to withdrawals were mental disturbances cardiac side effects and drug abuse or drug dependence Deaths were reportedly associated with seven products 196 Five medications beneficial for long term use are orlistat lorcaserin liraglutide phentermine topiramate and naltrexone bupropion 197 They result in weight loss after one year ranged from 3 0 to 6 7 kg 6 6 14 8 lbs over placebo 197 Orlistat liraglutide and naltrexone bupropion are available in both the United States and Europe phentermine topiramate is available only in the United States 198 European regulatory authorities rejected lorcaserin and phentermine topiramate in part because of associations of heart valve problems with lorcaserin and more general heart and blood vessel problems with phentermine topiramate 198 Lorcaserin was available in the United States and then removed from the market in 2020 due to its association with cancer 199 Orlistat use is associated with high rates of gastrointestinal side effects 200 and concerns have been raised about negative effects on the kidneys 201 There is no information on how these drugs affect longer term complications of obesity such as cardiovascular disease or death 5 however liraglutide when used for type 2 diabetes does reduce cardiovascular events 202 In 2019 a systematic review compared the effects on weight of various doses of fluoxetine 60 mg d 40 mg d 20 mg d 10 mg d in obese adults 203 When compared to placebo all dosages of fluoxetine appeared to contribute to weight loss but lead to increased risk of experiencing side effects such as dizziness drowsiness fatigue insomnia and nausea during period of treatment However these conclusions were from low certainty evidence 203 When comparing in the same review the effects of fluoxetine on weight of obese adults to other anti obesity agents omega 3 gel and not receiving a treatment the authors could not reach conclusive results due to poor quality of evidence 203 Among antipsychotic drugs for treating schizophrenia clozapine is the most effective but it also has the highest risk of causing the metabolic syndrome of which obesity is the main feature For people who gain weight because of clozapine taking metformin may reportedly improve three of the five components of the metabolic syndrome waist circumference fasting glucose and fasting triglycerides 204 Surgery The most effective treatment for obesity is bariatric surgery 6 20 The types of procedures include laparoscopic adjustable gastric banding Roux en Y gastric bypass vertical sleeve gastrectomy and biliopancreatic diversion 197 Surgery for severe obesity is associated with long term weight loss improvement in obesity related conditions 205 and decreased overall mortality however improved metabolic health results from the weight loss not the surgery 206 One study found a weight loss of between 14 and 25 depending on the type of procedure performed at 10 years and a 29 reduction in all cause mortality when compared to standard weight loss measures 207 Complications occur in about 17 of cases and reoperation is needed in 7 of cases 205 EpidemiologyMain article Epidemiology of obesity Share of adults with BMIs gt 30 2016 See or edit source data In earlier historical periods obesity was rare and achievable only by a small elite although already recognised as a problem for health But as prosperity increased in the Early Modern period it affected increasingly larger groups of the population 208 Prior to the 1970s obesity was a relatively rare condition even in the wealthiest of nations and when it did exist it tended to occur among the wealthy Then a confluence of events started to change the human condition The average BMI of populations in first world countries started to increase and consequently there was a rapid increase in the proportion of people overweight and obese 209 In 1997 the WHO formally recognized obesity as a global epidemic 109 As of 2008 the WHO estimates that at least 500 million adults greater than 10 are obese with higher rates among women than men 210 The global prevalence of obesity more than doubled between 1980 and 2014 In 2014 more than 600 million adults were obese equal to about 13 percent of the world s adult population 211 The percentage of adults affected in the United States as of 2015 2016 is about 39 6 overall 37 9 of males and 41 1 of females 212 In 2000 the World Health Organization WHO stated that overweight and obesity were replacing more traditional public health concerns such as undernutrition and infectious diseases as one of the most significant cause of poor health 213 The rate of obesity also increases with age at least up to 50 or 60 years old 214 and severe obesity in the United States Australia and Canada is increasing faster than the overall rate of obesity 28 215 216 The OECD has projected an increase in obesity rates until at least 2030 especially in the United States Mexico and England with rates reaching 47 39 and 35 respectively 217 Once considered a problem only of high income countries obesity rates are rising worldwide and affecting both the developed and developing world 218 These increases have been felt most dramatically in urban settings 210 Sex and gender based differences also influence the prevalence of obesity Globally there are more obese women than men but the numbers differ depending on how obesity is measured 219 220 HistoryEtymology Obesity is from the Latin obesitas which means stout fat or plump Esus is the past participle of edere to eat with ob over added to it 221 The Oxford English Dictionary documents its first usage in 1611 by Randle Cotgrave 222 Historical attitudes During the Middle Ages and the Renaissance obesity was often seen as a sign of wealth and was relatively common among the elite The Tuscan General Alessandro del Borro attributed to Charles Mellin 1645 223 Venus of Willendorf created 24 000 22 000 BC Ancient Greek medicine recognizes obesity as a medical disorder and records that the Ancient Egyptians saw it in the same way 208 Hippocrates wrote that Corpulence is not only a disease itself but the harbinger of others 2 The Indian surgeon Sushruta 6th century BCE related obesity to diabetes and heart disorders 224 He recommended physical work to help cure it and its side effects 224 For most of human history mankind struggled with food scarcity 225 Obesity has thus historically been viewed as a sign of wealth and prosperity It was common among high officials in Europe in the Middle Ages and the Renaissance 223 as well as in Ancient East Asian civilizations 226 In the 17th century English medical author Tobias Venner is credited with being one of the first to refer to the term as a societal disease in a published English language book 208 227 With the onset of the Industrial Revolution it was realized that the military and economic might of nations were dependent on both the body size and strength of their soldiers and workers 109 Increasing the average body mass index from what is now considered underweight to what is now the normal range played a significant role in the development of industrialized societies 109 Height and weight thus both increased through the 19th century in the developed world During the 20th century as populations reached their genetic potential for height weight began increasing much more than height resulting in obesity 109 In the 1950s increasing wealth in the developed world decreased child mortality but as body weight increased heart and kidney disease became more common 109 228 During this time period insurance companies realized the connection between weight and life expectancy and increased premiums for the obese 2 Many cultures throughout history have viewed obesity as the result of a character flaw The obesus or fat character in Ancient Greek comedy was a glutton and figure of mockery During Christian times the food was viewed as a gateway to the sins of sloth and lust 19 In modern Western culture excess weight is often regarded as unattractive and obesity is commonly associated with various negative stereotypes People of all ages can face social stigmatization and may be targeted by bullies or shunned by their peers 229 Public perceptions in Western society regarding healthy body weight differ from those regarding the weight that is considered ideal and both have changed since the beginning of the 20th century The weight that is viewed as an ideal has become lower since the 1920s This is illustrated by the fact that the average height of Miss America pageant winners increased by 2 from 1922 to 1999 while their average weight decreased by 12 230 On the other hand people s views concerning healthy weight have changed in the opposite direction In Britain the weight at which people considered themselves to be overweight was significantly higher in 2007 than in 1999 231 These changes are believed to be due to increasing rates of adiposity leading to increased acceptance of extra body fat as being normal 231 Obesity is still seen as a sign of wealth and well being in many parts of Africa This has become particularly common since the HIV epidemic began 2 The arts The first sculptural representations of the human body 20 000 35 000 years ago depict obese females Some attribute the Venus figurines to the tendency to emphasize fertility while others feel they represent fatness in the people of the time 19 Corpulence is however absent in both Greek and Roman art probably in keeping with their ideals regarding moderation This continued through much of Christian European history with only those of low socioeconomic status being depicted as obese 19 During the Renaissance some of the upper class began flaunting their large size as can be seen in portraits of Henry VIII of England and Alessandro dal Borro 19 Rubens 1577 1640 regularly depicted heavyset women in his pictures from which derives the term Rubenesque These women however still maintained the hourglass shape with its relationship to fertility 232 During the 19th century views on obesity changed in the Western world After centuries of obesity being synonymous with wealth and social status slimness began to be seen as the desirable standard 19 In his 1819 print The Belle Alliance or the Female Reformers of Blackburn artist George Cruikshank criticised the work of female reformers in Blackburn and used fatness as a means to portray them as unfeminine 233 Society and cultureEconomic impact In addition to its health impacts obesity leads to many problems including disadvantages in employment 234 235 and increased business costs These effects are felt by all levels of society from individuals to corporations to governments In 2005 the medical costs attributable to obesity in the US were an estimated 190 2 billion or 20 6 of all medical expenditures 236 237 238 while the cost of obesity in Canada was estimated at CA 2 billion in 1997 2 4 of total health costs 94 The total annual direct cost of overweight and obesity in Australia in 2005 was A 21 billion Overweight and obese Australians also received A 35 6 billion in government subsidies 239 The estimate range for annual expenditures on diet products is 40 billion to 100 billion in the US alone 240 The Lancet Commission on Obesity in 2019 called for a global treaty modelled on the WHO Framework Convention on Tobacco Control committing countries to address obesity and undernutrition explicitly excluding the food industry from policy development They estimate the global cost of obesity 2 trillion a year about or 2 8 of world GDP 241 Obesity prevention programs have been found to reduce the cost of treating obesity related disease However the longer people live the more medical costs they incur Researchers therefore conclude that reducing obesity may improve the public s health but it is unlikely to reduce overall health spending 242 Sin taxes such as a sugary drink tax have been implemented in certain countries globally to curb dietary and consumer habits and as an effort to offset the economic tolls Services accommodate obese people with specialized equipment such as much wider chairs 243 Obesity can lead to social stigmatization and disadvantages in employment 234 When compared to their normal weight counterparts obese workers on average have higher rates of absenteeism from work and take more disability leave thus increasing costs for employers and decreasing productivity 244 A study examining Duke University employees found that people with a BMI over 40 kg m2 filed twice as many workers compensation claims as those whose BMI was 18 5 24 9 kg m2 They also had more than 12 times as many lost work days The most common injuries in this group were due to falls and lifting thus affecting the lower extremities wrists or hands and backs 245 The Alabama State Employees Insurance Board approved a controversial plan to charge obese workers 25 a month for health insurance that would otherwise be free unless they take steps to lose weight and improve their health These measures started in January 2010 and apply to those state workers whose BMI exceeds 35 kg m2 and who fail to make improvements in their health after one year 246 Some research shows that obese people are less likely to be hired for a job and are less likely to be promoted 229 Obese people are also paid less than their non obese counterparts for an equivalent job obese women on average make 6 less and obese men make 3 less 247 Specific industries such as the airline healthcare and food industries have special concerns Due to rising rates of obesity airlines face higher fuel costs and pressures to increase seating width 248 In 2000 the extra weight of obese passengers cost airlines US 275 million 249 The healthcare industry has had to invest in special facilities for handling severely obese patients including special lifting equipment and bariatric ambulances 250 Costs for restaurants are increased by litigation accusing them of causing obesity 251 In 2005 the US Congress discussed legislation to prevent civil lawsuits against the food industry in relation to obesity however it did not become law 251 With the American Medical Association s 2013 classification of obesity as a chronic disease 21 it is thought that health insurance companies will more likely pay for obesity treatment counseling and surgery and the cost of research and development of fat treatment pills or gene therapy treatments should be more affordable if insurers help to subsidize their cost 252 The AMA classification is not legally binding however so health insurers still have the right to reject coverage for a treatment or procedure 252 In 2014 The European Court of Justice ruled that morbid obesity is a disability The Court said that if an employee s obesity prevents them from full and effective participation of that person in professional life on an equal basis with other workers then it shall be considered a disability and that firing someone on such grounds is discriminatory 253 Size acceptance See also Fat acceptance movement Social stigma of obesity Health at Every Size and Fat fetishism United States President William Howard Taft was often ridiculed for being overweight The principal goal of the fat acceptance movement is to decrease discrimination against people who are overweight and obese 254 255 However some in the movement are also attempting to challenge the established relationship between obesity and negative health outcomes 256 A number of organizations exist that promote the acceptance of obesity They have increased in prominence in the latter half of the 20th century 257 The US based National Association to Advance Fat Acceptance NAAFA was formed in 1969 and describes itself as a civil rights organization dedicated to ending size discrimination 258 The International Size Acceptance Association ISAA is a non governmental organization NGO which was founded in 1997 It has more of a global orientation and describes its mission as promoting size acceptance and helping to end weight based discrimination 259 These groups often argue for the recognition of obesity as a disability under the US Americans With Disabilities Act ADA The American legal system however has decided that the potential public health costs exceed the benefits of extending this anti discrimination law to cover obesity 256 Industry influence on research In 2015 the New York Times published an article on the Global Energy Balance Network a nonprofit founded in 2014 that advocated for people to focus on increasing exercise rather than reducing calorie intake to avoid obesity and to be healthy The organization was founded with at least 1 5M in funding from the Coca Cola Company and the company has provided 4M in research funding to the two founding scientists Gregory A Hand and Steven N Blair since 2008 260 261 Reports Many organizations have published reports pertaining to obesity In 1998 the first US Federal guidelines were published titled Clinical Guidelines on the Identification Evaluation and Treatment of Overweight and Obesity in Adults The Evidence Report 262 In 2006 the Canadian Obesity Network now known as Obesity Canada published the Canadian Clinical Practice Guidelines CPG on the Management and Prevention of Obesity in Adults and Children This is a comprehensive evidence based guideline to address the management and prevention of overweight and obesity in adults and children 94 In 2004 the United Kingdom Royal College of Physicians the Faculty of Public Health and the Royal College of Paediatrics and Child Health released the report Storing up Problems which highlighted the growing problem of obesity in the UK 263 The same year the House of Commons Health Select Committee published its most comprehensive inquiry ever undertaken into the impact of obesity on health and society in the UK and possible approaches to the problem 264 In 2006 the National Institute for Health and Clinical Excellence NICE issued a guideline on the diagnosis and management of obesity as well as policy implications for non healthcare organizations such as local councils 265 A 2007 report produced by Derek Wanless for the King s Fund warned that unless further action was taken obesity had the capacity to debilitate the National Health Service financially 266 In 2022 the National Institute for Health and Care Research NIHR published a comprehensive review of research on what local authorities can do to reduce obesity 194 The Obesity Policy Action OPA framework divides measure into upstream policies midstream policies and downstream policies Upstream policies have to do with changing society while midstream policies try to alter behaviors believed to contribute to obesity at the individual level while downstream policies treat currently obese people 267 Childhood obesityMain article Childhood obesity The healthy BMI range varies with the age and sex of the child Obesity in children and adolescents is defined as a BMI greater than the 95th percentile 268 The reference data that these percentiles are based on is from 1963 to 1994 and thus has not been affected by the recent increases in rates of obesity 269 Childhood obesity has reached epidemic proportions in the 21st century with rising rates in both the developed and the developing world Rates of obesity in Canadian boys have increased from 11 in the 1980s to over 30 in the 1990s while during this same time period rates increased from 4 to 14 in Brazilian children 270 In the UK there were 60 more obese children in 2005 compared to 1989 271 In the US the percentage of overweight and obese children increased to 16 in 2008 a 300 increase over the prior 30 years 272 As with obesity in adults many factors contribute to the rising rates of childhood obesity Changing diet and decreasing physical activity are believed to be the two most important causes for the recent increase in the incidence of child obesity 273 Advertising of unhealthy foods to children also contributes as it increases their consumption of the product 274 Antibiotics in the first 6 months of life have been associated with excess weight at age seven to twelve years of age 161 Because childhood obesity often persists into adulthood and is associated with numerous chronic illnesses children who are obese are often tested for hypertension diabetes hyperlipidemia and fatty liver disease 94 Treatments used in children are primarily lifestyle interventions and behavioral techniques although efforts to increase activity in children have had little success 275 In the United States medications are not FDA approved for use in this age group 270 Brief weight management interventions in primary care e g delivered by a physician or nurse practitioner have only a marginal positive effect in reducing childhood overweight or obesity 276 Multi component behaviour change interventions that include changes to dietary and physical activity may reduce BMI in the short term in children aged 6 to 11 years although the benefits are small and quality of evidence is low 277 Other animalsMain article Obesity in pets Obesity in pets is common in many countries In the United States 23 41 of dogs are overweight and about 5 1 are obese 278 The rate of obesity in cats was slightly higher at 6 4 278 In Australia the rate of obesity among dogs in a veterinary setting has been found to be 7 6 279 The risk of obesity in dogs is related to whether or not their owners are obese however there is no similar correlation between cats and their owners 280 See alsoPortal visceral hypothesisReferencesCitations a b c d e f g h i Obesity and overweight Fact sheet N 311 WHO January 2015 Retrieved 2 February 2016 a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad Haslam DW James WP October 2005 Obesity Lancet Review 366 9492 1197 1209 doi 10 1016 S0140 6736 05 67483 1 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