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Origin of COVID-19

December 18, 2023

Since the beginning of the COVID-19 pandemic, there have been efforts by scientists, governments, and others to determine the origin of the SARS-CoV-2 virus. Similar to other outbreaks,[1][2][3] the virus derived from a bat-borne virus and most likely was transmitted to humans via another animal in nature or during wildlife trade such as that in food markets.[11] While other explanations such as speculations that SARS-CoV-2 was accidentally released from a laboratory have been proposed,[12][13][14] such explanations are not supported by evidence.[15] Conspiracy theories about the virus's origin have also proliferated.[16]

SARS-CoV-2 has close genetic similarity to multiple previously identified bat coronaviruses, suggesting it crossed over into humans from bats.[7][17][18][19][20] Research is ongoing as to whether SARS-CoV-2 came directly from bats or indirectly through an intermediate host, such as pangolins,[21] civets,[22] treeshrews,[23] or raccoon dogs.[24][25] Genomic sequence evidence indicates the spillover event introducing SARS-CoV-2 to humans likely occurred in late 2019.[26][27] As with the 2002–2004 SARS-CoV-1 outbreak, efforts to trace the specific geographic and taxonomic origins of SARS-CoV-2 could take years, and results may be inconclusive.[28]

In July 2022, two papers published in Science described novel epidemiological and genetic evidence that suggested the pandemic likely began at the Huanan Seafood Wholesale Market and did not come from a laboratory.[29][30][31]

Zoonosis

See also: COVID-19 pandemic in Hubei
Main article: Zoonotic origins of COVID-19

While there are multiple proposed explanations for how SARS-CoV-2 was introduced into and evolved adaptations suited to human populations, there is significant evidence and agreement that the most likely original viral reservoir for SARS-CoV-2 is horseshoe bats. The closest known viral relatives of SARS-CoV-2 are RaTG13 and BANAL-52, sampled from horseshoe bat droppings in Yunnan province in China and Feuang, Laos, respectively. The evolutionary distance between SARS-CoV-2 and RaTG13 is estimated to be about 50 years (between 38 and 72 years).[32][33]

Bats are a significant reservoir species for a diverse range of coronaviruses, and humans have been found with antibodies for them suggesting that direct infection by bats is common. The zoonotic transmission of SARS-CoV-2 virus to humans took place in the context of exacerbating factors that could make such spillovers more likely. Human contact with bats has increased as human population centers encroach on bat habitats. [4][34] Several social and environmental factors including climate change, natural ecosystem destruction and wildlife trade have also increased the likelihood for the emergences of zoonosis.[35][36] One study made with the support of the European Union found climate change increased the likelihood of the pandemic by influencing distribution of bat species.[37][38]

The earliest human cases of SARS-CoV-2 were identified in Wuhan, but the index case remains unknown. RaTG13 was sampled from bats in a mine in Mojiang County, Yunnan,[4][39] located roughly 1,500 km (930 mi) away from Wuhan,[40] and there are relatively few bat coronaviruses from Hubei province, where Wuhan is located.[41]

Intermediate host

In addition to direct spillover, another pathway, considered highly likely by scientists, is that of transmission through an intermediate host.[10][42] Specifically, this implies that a cross species transmission occurred prior to the human outbreak and that it had pathogenic results on the animal. This pathway has the potential to allow for greater adaptation to human transmission via animals with more similar protein shapes to humans, though this is not required for the scenario to occur. The evolutionary separation from bat viruses is explained in this case by the virus' presence in an unknown species with less viral surveillance than bats.[43] The virus' ability to easily infect and adapt to additional species (including mink) provides evidence that such a route of transmission is possible.[4][42]

Unlikely scenarios

While the scientific consensus is that SARS-CoV-2 derived from viruses hosted in bats, the precise means by which this occurred has been sometimes subject to speculation. Below are some judged to be unlikely scenarios.

Cold/food chain

Another proposed introduction to humans is through fresh or frozen food products, referred to as the cold/food chain.[44] Scientists do not consider this to be a likely origin of SARS-CoV-2 in humans.[45] This scenario's source animal could be either a direct or intermediary species as described above. Many investigations centered around the Huanan Seafood Wholesale Market in Wuhan, which had an early cluster of cases. While there have been food-borne outbreaks of human viruses in the past, and evidence of re-introduction of SARS-CoV-2 into China through imported frozen foods, investigations found no conclusive evidence of viral contamination in products at the Huanan Market.[4][46]

Lab leak theory

This section is an excerpt from COVID-19 lab leak theory.[edit]
 
The Wuhan Institute of Virology in Wuhan, China

The COVID-19 lab leak theory, or lab leak hypothesis, is the idea that SARS-CoV-2, the virus that caused the COVID-19 pandemic, came from a laboratory. This claim is highly controversial; most scientists believe the virus spilled into human populations through natural zoonosis (transfer directly from an infected non-human animal), similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history.[47] Available evidence suggests that the SARS-CoV-2 virus was originally harbored by bats, and spread to humans from infected wild animals, functioning as an intermediate host, at the Huanan Seafood Market in Wuhan, Hubei, China, in December 2019.[51][52] Several candidate animal species have been identified as potential intermediate hosts.[59] There is no evidence SARS-CoV-2 existed in any laboratory prior to the pandemic,[60][61][62] or that any suspicious biosecurity incidents happened in any laboratory.[63]

Many scenarios proposed for a lab leak are characteristic of conspiracy theories.[64] Central to many is a misplaced suspicion about the proximity of the outbreak to a virology institute that studies coronaviruses, the Wuhan Institute of Virology (WIV). Most large Chinese cities have laboratories that study coronaviruses,[60][65] and virus outbreaks typically begin in rural areas, but are first noticed in large cities.[66] If a coronavirus outbreak occurs in China, there is a high likelihood it will occur near a large city, and therefore near a laboratory studying coronaviruses.[66][67] The idea of a leak at the WIV also gained support due to secrecy during the Chinese government's response.[60][68] The lab leak theory has been described as racist and xenophobic; belief in the lab leak theory is correlated with distrust of government and anti-China sentiment, and has kindled the latter.[citation needed] Scientists from WIV had previously collected SARS-related coronaviruses from bats in the wild, and allegations that they also performed undisclosed risky work on such viruses are central to some versions of the idea.[69][70] Some versions, particularly those alleging genome engineering, are based on misinformation or misrepresentations of scientific evidence.[71][72][73]

Investigations

Chinese government

See also: COVID-19 misinformation by China § Origin disinformation

The first investigation conducted in China was by the Wuhan Municipal Health Commission, responding to hospitals reporting cases of pneumonia of unknown etiology, resulting in the closure of the Huanan Seafood Wholesale Market on 1 January 2020 for sanitation and disinfection.[74] The Chinese Center for Disease Control and Prevention (CCDC) entered the market the same day and took samples; as the animals had been removed before public-health authorities came in, no animals were sampled, although that would have been more conclusive.[75][76]

In April 2020, China imposed restrictions on publishing academic research on the novel coronavirus. Investigations into the origin of the virus would receive extra scrutiny and must be approved by Central Government officials.[77][78] The restrictions do not ban research or publication, including with non-Chinese researchers; Ian Lipkin, a US scientist, has been working with a team of Chinese researchers under the auspices of the Chinese Center for Disease Control and Prevention, a Chinese government agency, to investigate the origin of the virus. Lipkin has long-standing relationships with Chinese officials, including premier Li Keqiang, because of his contributions to rapid testing for SARS in 2003.[79]

The Huanan live-animal market was suspected of being the source of the virus, as there was a major, early cluster of cases there. On 31 January 2021, a team of scientists led by the World Health Organization visited the market to investigate the origins of COVID-19.[80] Based on the existing evidence, the WHO concluded that the origin of the virus was still unknown, and the Chinese government insisted that the market was not the origin.[81][82][83] The Chinese government has long insisted that the virus originated outside China,[75] and until June 2021 denied that live animals were traded at the Huanan market.[84]

Some Chinese researchers had published a preprint analysis of the Huanan swab samples in February 2022, concluding that the coronavirus in the samples had likely been brought in by humans, not the animals on sale,[75] but omissions in the analysis had raised questions,[84] and the raw sample data had not yet been released.[85][75]

On March 4, 2023, the data from the swab samples of the Huanan live-animal market were released, or possibly leaked;[85] a preliminary analysis of this data was reviewed by the international research community, which said that it made an animal origin much more likely.[84][75] Although the samples do not definitively prove that the raccoon dog is the "missing" intermediate animal host in the bat-to-human transmission chain, it does show that common raccoon dogs were present in the Huanan market at the time of the initial SARS-CoV-2 outbreak, in areas that were also positive for SARS-CoV-2 RNA, and substantially strengthens this hypothesis as the proximal origin of the pandemic.[75][85]

An attempt by these researchers to collaborate with the Chinese researchers was not answered, but the raw data was removed from the online database.[84][75] On March 14, an international group of researchers presented a preliminary analysis at a meeting of the World Health Organization's Scientific Advisory Group for Origins of Novel Pathogens, at which Chinese COVID-19 researchers were also present.[75] On the sixteenth, George Gao, the former head of the CCDC and lead author on the February 2022 preprint, told Science that there was "nothing new" in the raw data, and refused to answer questions about why his research team had removed it from the database.[84][85]

On March 17, the WHO director-general said that the data should have been shared three years earlier, and called on China to be more transparent in its data-sharing.[75] There exists further data from further samples which has not yet been made public.[85][86] Maria Van Kerkhove, the WHO's COVID-19 technical lead, called for it to be made public immediately[75] (see Huanan live-animal market#Swabs).

United States government

Trump administration

On 6 February 2020, the director of the White House's Office of Science and Technology Policy requested the National Academies of Sciences, Engineering, and Medicine to convene a meeting of "experts, world class geneticists, coronavirus experts, and evolutionary biologists", to "assess what data, information and samples are needed to address the unknowns, in order to understand the evolutionary origins of COVID-19 and more effectively respond to both the outbreak and any resulting information".[87][88]

In April 2020, it was reported that the US intelligence community was investigating whether the virus came from an accidental leak from a Chinese lab. The hypothesis was one of several possibilities being pursued by the investigators. US Secretary of Defense Mark Esper said the results of the investigation were "inconclusive".[89][90] By the end of April 2020, the Office of the Director of National Intelligence said the US intelligence community believed the coronavirus was not man-made or genetically modified.[91][92]

US officials criticised the "terms of reference" allowing Chinese scientists to do the first phase of preliminary research.[93] On 15 January 2021, US Secretary of State Mike Pompeo said that to assist the WHO investigative team's work and ensure a transparent, thorough investigation of COVID-19's origin, the US was sharing new information and urging the WHO to press the Chinese government to address three specific issues, including the illnesses of several researchers inside the WIV in autumn 2019 "with symptoms consistent with both COVID-19 and common seasonal illnesses", the WIV's research on "RaTG13" and "gain of function", and the WIV's links to the People's Liberation Army.[94][95] On 18 January, the US called on China to allow the WHO's expert team to interview "care givers, former patients and lab workers" in the city of Wuhan, drawing a rebuke from the Chinese government. Australia also called for the WHO team to have access to "relevant data, information and key locations".[96]

A classified report from May 2020 by the Lawrence Livermore National Laboratory, a US government national laboratory, concluded that the hypothesis that the virus leaked from the WIV "is plausible and deserves further investigation", although the report also notes that the virus could have developed naturally, echoing the consensus of the American intelligence community, and provides no "smoking gun" towards either hypothesis.[97][98]

Biden administration

On 13 February 2021, the White House said it had "deep concerns" about both the way the WHO's findings were communicated and the process used to reach them. Mirroring concerns raised by the Trump administration, National Security Adviser Jake Sullivan stated that it was essential that the WHO-convened report be independent and "free from alteration by the Chinese government".[99] On 14 April 2021, the Director of National Intelligence Avril Haines, along with other Biden administration officials, said that they had not ruled out the possibility of a laboratory accident as the origin of the COVID-19 virus.[100]

On 26 May 2021, President Joe Biden directed the U.S. intelligence community to produce a report within 90 days on whether the COVID-19 virus originated from a human contact with an infected animal or from an accidental lab leak,[101] stating his national security staff said there is insufficient evidence to determine either hypothesis to be more likely.[102] On 26 August 2021, the Office of the Director of National Intelligence released an unclassified summary of their findings,[103] with the main point being that the report remained inconclusive as to the origin of the virus, with intelligence agencies divided on the question.[104] The report also concluded that the virus was most likely not genetically engineered, and that China had no foreknowledge of the virus prior to the outbreak. The report concluded that a final determination of the origin was unlikely without cooperation from the Chinese government, saying their prior lack of transparency "reflect[ed] in part China's government's own uncertainty about where an investigation could lead, as well as its frustration that the international community is using the issue to exert political pressure on China."[105] Chinese foreign ministry spokesman Wang Wenbin said that the US intelligence report was "unscientific and has no credibility".[106]

On 23 May 2021, The Wall Street Journal reported that a previously undisclosed US intelligence report stated that three researchers from the Wuhan Institute of Virology became ill enough in November 2019 to seek hospital care. The report did not specify what the illness was. Officials familiar with the intelligence differed as to the strength to which it corroborates the hypothesis that the virus responsible for COVID-19 was leaked from the WIV. The WSJ report notes that it is not unusual for people in China to go to the hospital with uncomplicated influenza or common cold symptoms.[107]

Yuan Zhiming, director of the WIV's Wuhan National Biosafety Laboratory, responded in the Global Times, a Chinese state media outlet, that the "claims are groundless".[108][109] Marion Koopmans, a member of the WHO study team, described the number of flu-like illnesses at the WIV in 2019 as "completely normal".[110] Workers at the WIV must provide yearly serum samples.[4][110] WIV virologist Shi Zhengli said in 2020 that, based on an evaluation of those serum samples, all staff tested negative for COVID-19 antibodies.[107]

The House Foreign Affairs Committee has investigated the origins of the pandemic, and heard classified briefings. The Republican minority issued a report in August 2021 that they believed the origin of the pandemic was an accidental lab escape.[111]

The resurgence of the theory of a laboratory accident was fueled in part by the publication, in May 2021, of early emails between Anthony Fauci and scientists discussing the issue, before deliberate manipulation was ruled out as of March 2020.[112]

On 14 July 2021, the House Committee on Science, Space and Technology held the first congressional hearing on the origins of the virus. Bill Foster, an Illinois Democrat who chaired the hearing, said the Chinese government's lack of transparency is not in itself evidence of a lab leak and cautioned that answers may not be known even after the administration produces its intelligence report.[113] Expert witnesses Stanley Perlman and David Relman presented to the congressman different proposed explanations for the origins of the virus and how to conduct further investigations.[114]

On 16 July 2021, CNN reported that Biden administration officials considered the lab leak theory "as credible" as the natural origins theory.[115] In October 2022, an interim report of a Republican member of a US Senate committee concluded that a lab origin was most likely, but offered "little new evidence", according to The New York Times.[116]

In February 2023, the United States Energy Department updated its assessment on the origins of the virus, shifting from "undecided" to "low confidence" in favor of a laboratory leak.[117] White House National Security Advisor Jake Sullivan responded to the report saying there was still "no definitive answer" to the pandemic origins' question.[118]

On 28 February 2023, the head of the Federal Bureau of Investigation Christopher Wray said the FBI believes Covid-19 most likely originated in the lab.[119]

On 20 March 2023, the COVID-19 Origin Act of 2023 was signed into law. On June 23, 2023, the Biden administration released its report, as required by the Act.[120]

World Health Organization

The World Health Organization has declared that finding where SARS-CoV-2 came from is a priority and that it is "essential for understanding how the pandemic started."[121] In May 2020, the World Health Assembly, which governs the World Health Organization (WHO), passed a motion calling for a "comprehensive, independent and impartial" study into the COVID-19 pandemic. A record 137 countries, including China, co-sponsored the motion, giving overwhelming international endorsement to the study.[122] In mid 2020, the World Health Organization (WHO) began negotiations with the government of China on conducting an official study into the origins of COVID-19.

In November 2020, the WHO published a two-phase study plan. The purpose of the first phase was to better understand how the virus "might have started circulating in Wuhan", and a second phase involves longer-term studies based on the findings of the first phase.[4][123] WHO director-general Tedros Adhanom said "We need to know the origin of this virus because it can help us to prevent future outbreaks," adding, "There is nothing to hide. We want to know the origin, and that's it." He also urged countries not to politicise the origin tracing process, saying that would only create barriers to learning the truth.[124]

In 2021, the World Health Assembly (on behalf of the WHO) commissioned a study conducted jointly between WHO experts and Chinese scientists.[4][93] Echoing the assessment of most virologists,[125][126][127] the study concluded that the virus most likely had a zoonotic origin in bats, possibly via an intermediate host. It also stated that a laboratory origin for the virus was "extremely unlikely".[128][12] WHO director-general Tedros Adhanom Ghebreyesus, in concert with various governments including the US and the EU, responded to the 2021 study report saying the matter still "requires further investigation".[129][130][131] In July 2021, Zeng Yixin, Vice Health Minister of the Chinese National Health Commission, said that China would not participate in a second phase of investigation, denouncing the decision to proceed as "shocking" and "arrogant".[132][133] In June 2022, a second round of investigations concluded that more investigations in the various possible pathways of emergence were necessary.[134][135] In response to the WHO's June 2022 report, Chinese Foreign Ministry spokesperson Zhao Lijian called the lab leak theory "a lie concocted by anti-China forces for political purposes, which has nothing to do with science".[136]

Phase 1

For the first phase, the WHO formed a team of ten researchers with expertise in virology, public health and animals to conduct a thorough study.[137] One of the team's tasks was to retrospectively ascertain what wildlife was being sold in local wet markets in Wuhan.[138] The WHO's phase one team arrived and quarantined in Wuhan, Hubei, China in January 2021.[96][139]

Members of the team included Thea Fisher, John Watson, Marion Koopmans, Dominic Dwyer, Vladimir Dedkov, Hung Nguyen-Viet, Fabian Leendertz, Peter Daszak, Farag El Moubasher, and Ken Maeda. The team also included five WHO experts led by Peter Ben Embarek, two Food and Agriculture Organization representatives, and two representatives from the World Organisation for Animal Health.[4]

The inclusion of Peter Daszak in the team stirred controversy. Daszak is the head of EcoHealth Alliance, a nonprofit that studies spillover events, and has been a longtime collaborator of over 15 years with Shi Zhengli, Wuhan Institute of Virology's director of the Center for Emerging Infectious Diseases.[140][141] While Daszak is highly knowledgeable about Chinese laboratories and the emergence of diseases in the area, his close connection with the WIV was seen by some as a conflict of interest in the WHO's study.[140][142] When a BBC News journalist asked about his relationship with the WIV, Daszak said, "We file our papers, it's all there for everyone to see."[143]

The team was denied access to raw data, including the list of early patients, swabs, and blood samples.[144] It was allowed only a few hours of supervised access to the Wuhan Institute of Virology.[145]

Findings

In February 2021, after conducting part of their study, the WHO stated that the likely origin of COVID-19 was a zoonotic event from a virus circulating in bats, likely through another animal carrier, and that the time of transmission to humans was likely towards the end of 2019.[81]

The Chinese and the international experts who jointly carried out the WHO-convened study consider it "extremely unlikely" that COVID-19 leaked from a lab.[81][146][147][148] No evidence of a lab leak from the Wuhan Institute of Virology was found by the WHO team, with team leader Peter Ben Embarek stating that it was "very unlikely" due to the safety protocols in place.[81] During a 60 Minutes interview with Lesley Stahl, Peter Daszak, another member of the WHO team, described the investigation process to be a series of questions and answers between the WHO team and the Wuhan lab staff. Stahl made the comment that the team was "just taking their word for it", to which Daszak replied, "Well, what else can we do? There's a limit to what you can do and we went right up to that limit. We asked them tough questions. They weren't vetted in advance. And the answers they gave, we found to be believable—correct and convincing."[149]

The investigation also stated that transfer from animals to humans was unlikely to have occurred at the Huanan Seafood Market, since infections without a known epidemiological link were confirmed before the outbreak around the market.[81] In an announcement that surprised some foreign experts, the joint investigation concluded that early transmission via the cold chain of frozen products was "possible".[81]

In March 2021, the WHO published a written report with the results of the study.[150] The joint team stated that there are four scenarios for introduction:[46]

  • direct zoonotic transmission to humans (spillover), assessed as "possible to likely"
  • introduction through an intermediate host followed by a spillover, assessed as "likely to very likely"
  • introduction through the (cold) food chain, assessed as "possible"
  • introduction through a laboratory incident, assessed as "extremely unlikely"

The report mentions that direct zoonotic transmission to humans has a precedent, as most current human coronaviruses originated in animals. Zoonotic transmission is also supported by the fact that RaTG13 binds to hACE2, although the fit is not optimal.[4][151]

The investigative team noted the requirement for further studies, noting that these would "potentially increase knowledge and understanding globally."[152][4]: 9 

Reactions

WHO director-general Tedros Adhanom, who was not directly involved with the investigation, said he was ready to dispatch additional missions involving specialist experts and that further research was required. He said in a statement, "Some explanations may be more probable than others, but for now all possibilities remain on the table."[153] He also said, "We have not yet found the source of the virus, and we must continue to follow the science and leave no stone unturned as we do." Tedros called on China to provide "more timely and comprehensive data sharing" as part of future investigations.[154]

News outlets noted that, though it was unrealistic to expect quick and huge results from the report, it "offered few clear-cut conclusions regarding the start of the pandemic", "failed to audit the Chinese official position at some parts of the report", and was "biased according to critics".[155][156][157][158] Other scientists praised how the report details the pathways that can shed light on the origin, if explored later.[159]

After the publication of the report, politicians, talk show hosts, journalists, and some scientists advanced unsupported claims that SARS-CoV-2 may have come from the WIV.[160] In the United States, calls to investigate a laboratory leak reached "fever pitch", fueling aggressive rhetoric resulting in antipathy towards people of Asian ancestry,[160][161] and the bullying of scientists.[162][163][164] The European Union, United States, and 13 other countries criticised the WHO-convened study, calling for transparency from China and access to the raw data and original samples.[165] Chinese officials described these criticisms as an attempt to politicise the study.[166] Scientists involved in the WHO report, including Liang Wannian, John Watson, and Peter Daszak, objected to the criticism, and said that the report was an example of the collaboration and dialogue required to successfully continue investigations into the matter.[167]

In a letter published in Science, a number of scientists, including Ralph Baric, argued that the accidental laboratory leak hypothesis had not been sufficiently investigated and remained possible, calling for greater clarity and additional data.[168][8] Their letter was criticized by some virologists and public health experts, who said that a "hostile" and "divisive" focus on the WIV was unsupported by evidence, and would cause Chinese scientists and authorities to share less, rather than more data.[160]

Phase 2

See also: Scientific Advisory Group for Origins of Novel Pathogens

On 27 May 2021, Danish epidemiologist Tina Fischer spoke on the This Week in Virology podcast, advocating for a second phase of the study to audit blood samples for COVID-19 antibodies in China.[169][170] WHO-convened study team member Marion Koopmans, on that same broadcast, advocated for WHO member states to make a decision on the second phase of the study, though she also cautioned that an investigatory audit of the laboratory itself may be inconclusive.[169][170] In early July 2021, WHO emergency chief Michael Ryan said the final details of phase 2 were being worked out in negotiations between WHO and its member states, as the WHO works "by persuasion" and cannot compel any member state (including China) to cooperate.[171]

In July 2021 China rejected WHO requests for greater transparency, cooperation, and access to data as part of Phase 2. On 16 July 2021, Foreign Ministry spokesperson Zhao Lijian declared that China's position was that future investigations should be conducted elsewhere and should focus on cold chain transmission and the US military's labs.[172] On 22 July 2021, the Chinese government held a press conference in which Zeng Yixin, Vice Health Minister of the National Health Commission (NHC), said that China would not participate in a second phase of the WHO's investigation, denouncing it as "shocking" and "arrogant".[132] He elaborated "In some aspects, the WHO's plan for next phase of investigation of the coronavirus origin doesn't respect common sense, and it's against science. It's impossible for us to accept such a plan."[133]

On 9 June 2022, the SAGO group, in development of its function of advisor to the WHO, published its first preliminary report. This report summarised existing findings and recommended that further studies be undertaken into possibly pathways of emergence.[134]

The Lancet COVID-19 Commission task force

In November 2020, Richard Horton, editor of The Lancet, appointed economist Jeffrey Sachs as chair of its COVID-19 Commission, with wide-ranging goals relating to the virus and pandemic.[173][174][175][176] Sachs set up a number of task forces, including one on the origins of the virus. Sachs appointed Peter Daszak, a colleague of Sachs' at Columbia, to head this task force, two weeks after the Trump administration prematurely ended an federal grant supporting a project led by Daszak, EcoHealth Alliance, which worked with the Wuhan Institute of Virology.[177] This appointment was criticised as creating a conflict of interest, for instance by Richard Ebright, chemical biologist at Rutgers University, who called the commission an "entirely Potemkin commission" in the National Review.[177]

Daszak stated that the task force was formed to "conduct a thorough and rigorous investigation into the origins and early spread of SARS-CoV-2". The task force has twelve members with backgrounds in One Health, outbreak investigation, virology, lab biosecurity and disease ecology.[178][179] The task force planned to analyse scientific findings and did not plan to visit China.[176] However, as Sachs became increasingly drawn to the lab leak theory, he came into conflict with Daszak and his task force.[177] In June 2021, The Lancet announced that Daszak had recused himself from the commission.[180] On 25 September 2021, the task force work was folded after procedural concerns and a need to broaden its scope to examine transparency and government regulation of risky laboratory research.[181] However, it continued to conduct its work independently.[177]

In September 2022, the Lancet commission published a wide-ranging report on the pandemic, including commentary on the virus origin overseen by the group's chairman, economist Jeffrey Sachs.[182] The report suggested that the virus may have originated from an American laboratory, a notion promoted by Sachs since late 2020, including in 2022 on the podcast of anti-vaxx conspiracy theorist Robert F. Kennedy Jr.[177][183][184] Reacting to the Commission report, virologist Angela Rasmussen commented that this may have been "one of The Lancet's most shameful moments regarding its role as a steward and leader in communicating crucial findings about science and medicine".[184] Virologist David Robertson said the invocation of US laboratory involvement was "wild speculation" and that "it's really disappointing to see such a potentially influential report contributing to further misinformation on such an important topic".[184]

The task force published their own report in October 2022, saying they concluded there was "overwhelming" evidence of a natural spillover, but they also accepted the possibility of a lab leak.[177][185]

Independent investigations

In June 2021, the NIH announced that a set of sequence data had been removed from the Sequence Read Archive (SRA) in June 2020. The removal was performed according to standard practice at the request of the investigators who owned the rights to the sequences, with the investigators' rationale that the sequences would be submitted to another database.[186][187] The investigators subsequently published a paper in an academic journal the same month they were removed from the NIH database which described the sequences in detail and discussed their evolutionary relationship to other sequences, but did not include the raw data.[188] Virologist David Robertson said that it was difficult to conclude it was a cover-up rather than the more likely explanation: a mundane deletion of data without malfeasance.[189][190] The missing genetic sequence data was restored in a correction published 29 July 2021 after it was stated to be a copy-edit error.[191][192]

In March 2023, an international team of virus experts from University of Arizona, Scripps Research Institute, and University of Sydney found genetic evidence that COVID-19 may have originated from the illegal trade of infected raccoon dogs in Wuhan, China, supporting the zoonotic transmission scenario. Swabs taken from the Huanan Seafood Wholesale Market in January 2020, which tested positive for coronavirus, contained large amounts of genetic material from raccoon dogs.[193]

International calls for investigations

In April 2020, Australian foreign minister Marise Payne and Australian prime minister Scott Morrison called for an independent international inquiry into the origins of the coronavirus pandemic.[194][195] A few days later, German chancellor Angela Merkel also pressed China for transparency about the origin of the coronavirus, following similar concerns raised by the French president Emmanuel Macron.[196] The UK also expressed support for an investigation, although both France and UK said the priority at the time was to first fight the virus.[197][198] Some public health experts have also called for an independent examination of COVID-19's origins, "arguing WHO does not have the political clout to conduct such a forensic analysis".[199]

In May 2021, Prime Minister Justin Trudeau told reporters Canada would "support the call by the United States and others to better understand the origins of COVID-19."[200][201] In June 2021, at the G7 summit in Cornwall, the attending leaders issued a joint statement calling for a new investigation, citing China's refusal to cooperate with certain aspects of the original WHO-convened study.[202] This resistance to international pressure was one of the key findings of a Wall Street Journal investigation into the pandemic origin.[203]

The divisive nature of the debate has led scientists to call for less political pressure on the topic.[112] Public health analysts have remarked that the debate over the origins of SARS-CoV-2 is fueling unnecessary confrontation, resulting in bullying and harassment of scientists,[204] and is deepening existing geopolitical tensions and hindering collaboration at a time where such mutual cooperation is required, both to deal with the current pandemic and in preparation for future such outbreaks.[205][206] This comes in the face of scientists having predicted such events for decades: according to Katie Woolaston, researcher at the Queensland University of Technology, "The environmental drivers of pandemics are not being widely discussed". The debate comes at a moment of difficult global relations with Chinese authorities. Researchers have noted that the politicisation of the debate is making the process more difficult, and that words are often twisted to become "fodder for conspiracy theories".[207][208]

A letter published in The Lancet in July 2021 remarked that the atmosphere of speculation surrounding the issue was of no help in making an objective assessment of the situation.[209] In response to this letter, in a communication published in the same journal, a small group of researchers opposed the idea that scientists should promote unity and called for openness to alternative hypotheses.[210] Despite the unlikelihood of the event, and although definitive answers are likely to take years of research, biosecurity experts have called for a review of global biosecurity policies, citing known gaps in international standards for biosafety.[205][207] The situation has also reignited a debate over gain-of-function research, although the intense political rhetoric surrounding the issue has threatened to sideline serious inquiry over policy in this domain.[211]

See also

References

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  47. ^ See numerous reliable sources which support this:
    • Pekar, Jonathan (26 July 2022). "The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2". Science. 377 (6609): 960–966. Bibcode:2022Sci...377..960P. doi:10.1126/science.abp8337. PMC 9348752. PMID 35881005.
    • Jiang, Xiaowei; Wang, Ruoqi (25 August 2022). "Wildlife trade is likely the source of SARS-CoV-2". Science. 377 (6609): 925–926. Bibcode:2022Sci...377..925J. doi:10.1126/science.add8384. PMID 36007033. S2CID 251843410. Retrieved 20 November 2022. Although the most probable reservoir animal for SARS-CoV-2 is Rhinolophus bats (2, 3), zoonotic spillovers likely involve an intermediate animal.
    • Holmes EC, Goldstein SA, Rasmussen AL, Robertson DL, Crits-Christoph A, et al. (September 2021). "The origins of SARS-CoV-2: A critical review". Cell (Review). 184 (19): 4848–4856. doi:10.1016/j.cell.2021.08.017. PMC 8373617. PMID 34480864. As for the vast majority of human viruses, the most parsimonious explanation for the origin of SARS-CoV-2 is a zoonotic event...There is currently no evidence that SARS-CoV-2 has a laboratory origin. There is no evidence that any early cases had any connection to the WIV, in contrast to the clear epidemiological links to animal markets in Wuhan, nor evidence that the WIV possessed or worked on a progenitor of SARS-CoV-2 prior to the pandemic.
    • Bolsen, Toby; Palm, Risa; Kingsland, Justin T. (October 2020). "Framing the Origins of COVID-19". Science Communication. 42 (5): 562–585. doi:10.1177/1075547020953603. ISSN 1075-5470. S2CID 221614695. Retrieved 24 May 2023. Individuals may learn about the origins of COVID-19 through exposure to stories that communicate either what most scientists believe (i.e., zoonotic transmission) or through exposure to conspiratorial claims (e.g., the virus was created in a research laboratory in China).
    • Robertson, Lori (2 March 2023). "Still No Determination on COVID-19 Origin". FactCheck.org. Retrieved 24 May 2023. most scientists suspect a zoonotic spillover in which the virus transferred from bats, or through an intermediate animal, to humans — the same way the SARS and MERS coronaviruses originated.
    • Gajilan, A. Chris (19 September 2021). "Covid-19 origins: Why the search for the source is vital". CNN. Retrieved 24 May 2023. The zoonotic hypothesis hinges on the idea that the virus spilled over from animals to humans, either directly through a bat, or through some other intermediary animal. Most scientists say that this is the likely origin, given that 75% of all emerging diseases have jumped from animals into humans.
    • McDonald •, Jessica (28 June 2021). "Where Did COVID-19 Start? The Facts and Mysteries of Its Origin". NBC 5 Dallas-Fort Worth. Retrieved 24 May 2023. The default answer for most scientists has been that the virus, SARS-CoV-2, probably made the jump to humans from bats, if it was a direct spillover — or, more likely, through one or more intermediate mammals.
    • MCKEEVER, AMY (6 April 2021). "We still don't know the origins of the coronavirus. Here are 4 scenarios". National Geographic. Retrieved 24 May 2023. The most controversial hypothesis for the origin of SARS-CoV-2 is also the one that most scientists agree is the least likely: that the virus somehow leaked out of a laboratory in Wuhan where researchers study bat coronaviruses.
    • Ball, Philip. "Three years on, Covid lab-leak theories aren't going away. This is why". www.prospectmagazine.co.uk. The leading theory now backed by most scientists is that the virus arose in wild bats and found its way into animals (perhaps via a pangolin or a civet cat) sold at the Huanan Seafood Wholesale Market in Wuhan.
    • Jackson, Christina (21 September 2020). "Controversy Aside, Why the Source of COVID-19 Matters". GEN - Genetic Engineering and Biotechnology News. Retrieved 24 May 2023. Most scientists studying the origins of COVID-19 have concluded that the SARS-CoV-2 virus probably evolved naturally and infected humans via incidental contact with a wild or domesticated animal.
    • McCarthy, Simone (16 September 2021). "Bat-human virus spillovers may be very common, study finds". South China Morning Post. Retrieved 24 May 2023. Questions have been raised about whether the virus could have leaked from a laboratory studying related viruses in Wuhan – a scenario most scientists...feel is less likely than a natural spillover.
    • Danner, Chas (26 May 2021). "Biden Joins the COVID Lab-Leak-Theory Debate". Intelligencer. Retrieved 24 May 2023. There continues to be no evidence at all for the conspiracy theory that SARS-CoV-2, the virus that causes COVID-19, was developed as some kind of bioweapon, and most scientists believe that the majority of available evidence indicates the virus jumped from animal to human.
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  51. ^ There were two landmark origins studies published side-by-side in Science in July 2022:[48]
    • Worobey et al. "The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic"[49]
    • Pekar et al. "The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2".[50]
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December 18, 2023
origin, covid, been, suggested, that, zoonotic, origins, covid, merged, into, this, article, discuss, proposed, since, november, 2023, since, beginning, covid, pandemic, there, have, been, efforts, scientists, governments, others, determine, origin, sars, viru. It has been suggested that Zoonotic origins of COVID 19 be merged into this article Discuss Proposed since November 2023 Since the beginning of the COVID 19 pandemic there have been efforts by scientists governments and others to determine the origin of the SARS CoV 2 virus Similar to other outbreaks 1 2 3 the virus derived from a bat borne virus and most likely was transmitted to humans via another animal in nature or during wildlife trade such as that in food markets 11 While other explanations such as speculations that SARS CoV 2 was accidentally released from a laboratory have been proposed 12 13 14 such explanations are not supported by evidence 15 Conspiracy theories about the virus s origin have also proliferated 16 SARS CoV 2 has close genetic similarity to multiple previously identified bat coronaviruses suggesting it crossed over into humans from bats 7 17 18 19 20 Research is ongoing as to whether SARS CoV 2 came directly from bats or indirectly through an intermediate host such as pangolins 21 civets 22 treeshrews 23 or raccoon dogs 24 25 Genomic sequence evidence indicates the spillover event introducing SARS CoV 2 to humans likely occurred in late 2019 26 27 As with the 2002 2004 SARS CoV 1 outbreak efforts to trace the specific geographic and taxonomic origins of SARS CoV 2 could take years and results may be inconclusive 28 In July 2022 two papers published in Science described novel epidemiological and genetic evidence that suggested the pandemic likely began at the Huanan Seafood Wholesale Market and did not come from a laboratory 29 30 31 Contents 1 Zoonosis 1 1 Intermediate host 2 Unlikely scenarios 2 1 Cold food chain 2 2 Lab leak theory 3 Investigations 3 1 Chinese government 3 2 United States government 3 2 1 Trump administration 3 2 2 Biden administration 3 3 World Health Organization 3 3 1 Phase 1 3 3 1 1 Findings 3 3 1 2 Reactions 3 3 2 Phase 2 3 4 The Lancet COVID 19 Commission task force 3 5 Independent investigations 3 6 International calls for investigations 4 See also 5 ReferencesZoonosisSee also COVID 19 pandemic in HubeiMain article Zoonotic origins of COVID 19 While there are multiple proposed explanations for how SARS CoV 2 was introduced into and evolved adaptations suited to human populations there is significant evidence and agreement that the most likely original viral reservoir for SARS CoV 2 is horseshoe bats The closest known viral relatives of SARS CoV 2 are RaTG13 and BANAL 52 sampled from horseshoe bat droppings in Yunnan province in China and Feuang Laos respectively The evolutionary distance between SARS CoV 2 and RaTG13 is estimated to be about 50 years between 38 and 72 years 32 33 Bats are a significant reservoir species for a diverse range of coronaviruses and humans have been found with antibodies for them suggesting that direct infection by bats is common The zoonotic transmission of SARS CoV 2 virus to humans took place in the context of exacerbating factors that could make such spillovers more likely Human contact with bats has increased as human population centers encroach on bat habitats 4 34 Several social and environmental factors including climate change natural ecosystem destruction and wildlife trade have also increased the likelihood for the emergences of zoonosis 35 36 One study made with the support of the European Union found climate change increased the likelihood of the pandemic by influencing distribution of bat species 37 38 The earliest human cases of SARS CoV 2 were identified in Wuhan but the index case remains unknown RaTG13 was sampled from bats in a mine in Mojiang County Yunnan 4 39 located roughly 1 500 km 930 mi away from Wuhan 40 and there are relatively few bat coronaviruses from Hubei province where Wuhan is located 41 Intermediate host In addition to direct spillover another pathway considered highly likely by scientists is that of transmission through an intermediate host 10 42 Specifically this implies that a cross species transmission occurred prior to the human outbreak and that it had pathogenic results on the animal This pathway has the potential to allow for greater adaptation to human transmission via animals with more similar protein shapes to humans though this is not required for the scenario to occur The evolutionary separation from bat viruses is explained in this case by the virus presence in an unknown species with less viral surveillance than bats 43 The virus ability to easily infect and adapt to additional species including mink provides evidence that such a route of transmission is possible 4 42 Unlikely scenariosWhile the scientific consensus is that SARS CoV 2 derived from viruses hosted in bats the precise means by which this occurred has been sometimes subject to speculation Below are some judged to be unlikely scenarios Cold food chain Another proposed introduction to humans is through fresh or frozen food products referred to as the cold food chain 44 Scientists do not consider this to be a likely origin of SARS CoV 2 in humans 45 This scenario s source animal could be either a direct or intermediary species as described above Many investigations centered around the Huanan Seafood Wholesale Market in Wuhan which had an early cluster of cases While there have been food borne outbreaks of human viruses in the past and evidence of re introduction of SARS CoV 2 into China through imported frozen foods investigations found no conclusive evidence of viral contamination in products at the Huanan Market 4 46 Lab leak theory This section is an excerpt from COVID 19 lab leak theory edit nbsp The Wuhan Institute of Virology in Wuhan ChinaThe COVID 19 lab leak theory or lab leak hypothesis is the idea that SARS CoV 2 the virus that caused the COVID 19 pandemic came from a laboratory This claim is highly controversial most scientists believe the virus spilled into human populations through natural zoonosis transfer directly from an infected non human animal similar to the SARS CoV 1 and MERS CoV outbreaks and consistent with other pandemics in human history 47 Available evidence suggests that the SARS CoV 2 virus was originally harbored by bats and spread to humans from infected wild animals functioning as an intermediate host at the Huanan Seafood Market in Wuhan Hubei China in December 2019 51 52 Several candidate animal species have been identified as potential intermediate hosts 59 There is no evidence SARS CoV 2 existed in any laboratory prior to the pandemic 60 61 62 or that any suspicious biosecurity incidents happened in any laboratory 63 Many scenarios proposed for a lab leak are characteristic of conspiracy theories 64 Central to many is a misplaced suspicion about the proximity of the outbreak to a virology institute that studies coronaviruses the Wuhan Institute of Virology WIV Most large Chinese cities have laboratories that study coronaviruses 60 65 and virus outbreaks typically begin in rural areas but are first noticed in large cities 66 If a coronavirus outbreak occurs in China there is a high likelihood it will occur near a large city and therefore near a laboratory studying coronaviruses 66 67 The idea of a leak at the WIV also gained support due to secrecy during the Chinese government s response 60 68 The lab leak theory has been described as racist and xenophobic belief in the lab leak theory is correlated with distrust of government and anti China sentiment and has kindled the latter citation needed Scientists from WIV had previously collected SARS related coronaviruses from bats in the wild and allegations that they also performed undisclosed risky work on such viruses are central to some versions of the idea 69 70 Some versions particularly those alleging genome engineering are based on misinformation or misrepresentations of scientific evidence 71 72 73 InvestigationsChinese government See also COVID 19 misinformation by China Origin disinformation The first investigation conducted in China was by the Wuhan Municipal Health Commission responding to hospitals reporting cases of pneumonia of unknown etiology resulting in the closure of the Huanan Seafood Wholesale Market on 1 January 2020 for sanitation and disinfection 74 The Chinese Center for Disease Control and Prevention CCDC entered the market the same day and took samples as the animals had been removed before public health authorities came in no animals were sampled although that would have been more conclusive 75 76 In April 2020 China imposed restrictions on publishing academic research on the novel coronavirus Investigations into the origin of the virus would receive extra scrutiny and must be approved by Central Government officials 77 78 The restrictions do not ban research or publication including with non Chinese researchers Ian Lipkin a US scientist has been working with a team of Chinese researchers under the auspices of the Chinese Center for Disease Control and Prevention a Chinese government agency to investigate the origin of the virus Lipkin has long standing relationships with Chinese officials including premier Li Keqiang because of his contributions to rapid testing for SARS in 2003 79 The Huanan live animal market was suspected of being the source of the virus as there was a major early cluster of cases there On 31 January 2021 a team of scientists led by the World Health Organization visited the market to investigate the origins of COVID 19 80 Based on the existing evidence the WHO concluded that the origin of the virus was still unknown and the Chinese government insisted that the market was not the origin 81 82 83 The Chinese government has long insisted that the virus originated outside China 75 and until June 2021 denied that live animals were traded at the Huanan market 84 Some Chinese researchers had published a preprint analysis of the Huanan swab samples in February 2022 concluding that the coronavirus in the samples had likely been brought in by humans not the animals on sale 75 but omissions in the analysis had raised questions 84 and the raw sample data had not yet been released 85 75 On March 4 2023 the data from the swab samples of the Huanan live animal market were released or possibly leaked 85 a preliminary analysis of this data was reviewed by the international research community which said that it made an animal origin much more likely 84 75 Although the samples do not definitively prove that the raccoon dog is the missing intermediate animal host in the bat to human transmission chain it does show that common raccoon dogs were present in the Huanan market at the time of the initial SARS CoV 2 outbreak in areas that were also positive for SARS CoV 2 RNA and substantially strengthens this hypothesis as the proximal origin of the pandemic 75 85 An attempt by these researchers to collaborate with the Chinese researchers was not answered but the raw data was removed from the online database 84 75 On March 14 an international group of researchers presented a preliminary analysis at a meeting of the World Health Organization s Scientific Advisory Group for Origins of Novel Pathogens at which Chinese COVID 19 researchers were also present 75 On the sixteenth George Gao the former head of the CCDC and lead author on the February 2022 preprint told Science that there was nothing new in the raw data and refused to answer questions about why his research team had removed it from the database 84 85 On March 17 the WHO director general said that the data should have been shared three years earlier and called on China to be more transparent in its data sharing 75 There exists further data from further samples which has not yet been made public 85 86 Maria Van Kerkhove the WHO s COVID 19 technical lead called for it to be made public immediately 75 see Huanan live animal market Swabs United States government Trump administration On 6 February 2020 the director of the White House s Office of Science and Technology Policy requested the National Academies of Sciences Engineering and Medicine to convene a meeting of experts world class geneticists coronavirus experts and evolutionary biologists to assess what data information and samples are needed to address the unknowns in order to understand the evolutionary origins of COVID 19 and more effectively respond to both the outbreak and any resulting information 87 88 In April 2020 it was reported that the US intelligence community was investigating whether the virus came from an accidental leak from a Chinese lab The hypothesis was one of several possibilities being pursued by the investigators US Secretary of Defense Mark Esper said the results of the investigation were inconclusive 89 90 By the end of April 2020 the Office of the Director of National Intelligence said the US intelligence community believed the coronavirus was not man made or genetically modified 91 92 US officials criticised the terms of reference allowing Chinese scientists to do the first phase of preliminary research 93 On 15 January 2021 US Secretary of State Mike Pompeo said that to assist the WHO investigative team s work and ensure a transparent thorough investigation of COVID 19 s origin the US was sharing new information and urging the WHO to press the Chinese government to address three specific issues including the illnesses of several researchers inside the WIV in autumn 2019 with symptoms consistent with both COVID 19 and common seasonal illnesses the WIV s research on RaTG13 and gain of function and the WIV s links to the People s Liberation Army 94 95 On 18 January the US called on China to allow the WHO s expert team to interview care givers former patients and lab workers in the city of Wuhan drawing a rebuke from the Chinese government Australia also called for the WHO team to have access to relevant data information and key locations 96 A classified report from May 2020 by the Lawrence Livermore National Laboratory a US government national laboratory concluded that the hypothesis that the virus leaked from the WIV is plausible and deserves further investigation although the report also notes that the virus could have developed naturally echoing the consensus of the American intelligence community and provides no smoking gun towards either hypothesis 97 98 Biden administration On 13 February 2021 the White House said it had deep concerns about both the way the WHO s findings were communicated and the process used to reach them Mirroring concerns raised by the Trump administration National Security Adviser Jake Sullivan stated that it was essential that the WHO convened report be independent and free from alteration by the Chinese government 99 On 14 April 2021 the Director of National Intelligence Avril Haines along with other Biden administration officials said that they had not ruled out the possibility of a laboratory accident as the origin of the COVID 19 virus 100 On 26 May 2021 President Joe Biden directed the U S intelligence community to produce a report within 90 days on whether the COVID 19 virus originated from a human contact with an infected animal or from an accidental lab leak 101 stating his national security staff said there is insufficient evidence to determine either hypothesis to be more likely 102 On 26 August 2021 the Office of the Director of National Intelligence released an unclassified summary of their findings 103 with the main point being that the report remained inconclusive as to the origin of the virus with intelligence agencies divided on the question 104 The report also concluded that the virus was most likely not genetically engineered and that China had no foreknowledge of the virus prior to the outbreak The report concluded that a final determination of the origin was unlikely without cooperation from the Chinese government saying their prior lack of transparency reflect ed in part China s government s own uncertainty about where an investigation could lead as well as its frustration that the international community is using the issue to exert political pressure on China 105 Chinese foreign ministry spokesman Wang Wenbin said that the US intelligence report was unscientific and has no credibility 106 On 23 May 2021 The Wall Street Journal reported that a previously undisclosed US intelligence report stated that three researchers from the Wuhan Institute of Virology became ill enough in November 2019 to seek hospital care The report did not specify what the illness was Officials familiar with the intelligence differed as to the strength to which it corroborates the hypothesis that the virus responsible for COVID 19 was leaked from the WIV The WSJ report notes that it is not unusual for people in China to go to the hospital with uncomplicated influenza or common cold symptoms 107 Yuan Zhiming director of the WIV s Wuhan National Biosafety Laboratory responded in the Global Times a Chinese state media outlet that the claims are groundless 108 109 Marion Koopmans a member of the WHO study team described the number of flu like illnesses at the WIV in 2019 as completely normal 110 Workers at the WIV must provide yearly serum samples 4 110 WIV virologist Shi Zhengli said in 2020 that based on an evaluation of those serum samples all staff tested negative for COVID 19 antibodies 107 The House Foreign Affairs Committee has investigated the origins of the pandemic and heard classified briefings The Republican minority issued a report in August 2021 that they believed the origin of the pandemic was an accidental lab escape 111 The resurgence of the theory of a laboratory accident was fueled in part by the publication in May 2021 of early emails between Anthony Fauci and scientists discussing the issue before deliberate manipulation was ruled out as of March 2020 112 On 14 July 2021 the House Committee on Science Space and Technology held the first congressional hearing on the origins of the virus Bill Foster an Illinois Democrat who chaired the hearing said the Chinese government s lack of transparency is not in itself evidence of a lab leak and cautioned that answers may not be known even after the administration produces its intelligence report 113 Expert witnesses Stanley Perlman and David Relman presented to the congressman different proposed explanations for the origins of the virus and how to conduct further investigations 114 On 16 July 2021 CNN reported that Biden administration officials considered the lab leak theory as credible as the natural origins theory 115 In October 2022 an interim report of a Republican member of a US Senate committee concluded that a lab origin was most likely but offered little new evidence according to The New York Times 116 In February 2023 the United States Energy Department updated its assessment on the origins of the virus shifting from undecided to low confidence in favor of a laboratory leak 117 White House National Security Advisor Jake Sullivan responded to the report saying there was still no definitive answer to the pandemic origins question 118 On 28 February 2023 the head of the Federal Bureau of Investigation Christopher Wray said the FBI believes Covid 19 most likely originated in the lab 119 On 20 March 2023 the COVID 19 Origin Act of 2023 was signed into law On June 23 2023 the Biden administration released its report as required by the Act 120 World Health Organization The World Health Organization has declared that finding where SARS CoV 2 came from is a priority and that it is essential for understanding how the pandemic started 121 In May 2020 the World Health Assembly which governs the World Health Organization WHO passed a motion calling for a comprehensive independent and impartial study into the COVID 19 pandemic A record 137 countries including China co sponsored the motion giving overwhelming international endorsement to the study 122 In mid 2020 the World Health Organization WHO began negotiations with the government of China on conducting an official study into the origins of COVID 19 In November 2020 the WHO published a two phase study plan The purpose of the first phase was to better understand how the virus might have started circulating in Wuhan and a second phase involves longer term studies based on the findings of the first phase 4 123 WHO director general Tedros Adhanom said We need to know the origin of this virus because it can help us to prevent future outbreaks adding There is nothing to hide We want to know the origin and that s it He also urged countries not to politicise the origin tracing process saying that would only create barriers to learning the truth 124 In 2021 the World Health Assembly on behalf of the WHO commissioned a study conducted jointly between WHO experts and Chinese scientists 4 93 Echoing the assessment of most virologists 125 126 127 the study concluded that the virus most likely had a zoonotic origin in bats possibly via an intermediate host It also stated that a laboratory origin for the virus was extremely unlikely 128 12 WHO director general Tedros Adhanom Ghebreyesus in concert with various governments including the US and the EU responded to the 2021 study report saying the matter still requires further investigation 129 130 131 In July 2021 Zeng Yixin Vice Health Minister of the Chinese National Health Commission said that China would not participate in a second phase of investigation denouncing the decision to proceed as shocking and arrogant 132 133 In June 2022 a second round of investigations concluded that more investigations in the various possible pathways of emergence were necessary 134 135 In response to the WHO s June 2022 report Chinese Foreign Ministry spokesperson Zhao Lijian called the lab leak theory a lie concocted by anti China forces for political purposes which has nothing to do with science 136 Phase 1 For the first phase the WHO formed a team of ten researchers with expertise in virology public health and animals to conduct a thorough study 137 One of the team s tasks was to retrospectively ascertain what wildlife was being sold in local wet markets in Wuhan 138 The WHO s phase one team arrived and quarantined in Wuhan Hubei China in January 2021 96 139 Members of the team included Thea Fisher John Watson Marion Koopmans Dominic Dwyer Vladimir Dedkov Hung Nguyen Viet Fabian Leendertz Peter Daszak Farag El Moubasher and Ken Maeda The team also included five WHO experts led by Peter Ben Embarek two Food and Agriculture Organization representatives and two representatives from the World Organisation for Animal Health 4 The inclusion of Peter Daszak in the team stirred controversy Daszak is the head of EcoHealth Alliance a nonprofit that studies spillover events and has been a longtime collaborator of over 15 years with Shi Zhengli Wuhan Institute of Virology s director of the Center for Emerging Infectious Diseases 140 141 While Daszak is highly knowledgeable about Chinese laboratories and the emergence of diseases in the area his close connection with the WIV was seen by some as a conflict of interest in the WHO s study 140 142 When a BBC News journalist asked about his relationship with the WIV Daszak said We file our papers it s all there for everyone to see 143 The team was denied access to raw data including the list of early patients swabs and blood samples 144 It was allowed only a few hours of supervised access to the Wuhan Institute of Virology 145 Findings In February 2021 after conducting part of their study the WHO stated that the likely origin of COVID 19 was a zoonotic event from a virus circulating in bats likely through another animal carrier and that the time of transmission to humans was likely towards the end of 2019 81 The Chinese and the international experts who jointly carried out the WHO convened study consider it extremely unlikely that COVID 19 leaked from a lab 81 146 147 148 No evidence of a lab leak from the Wuhan Institute of Virology was found by the WHO team with team leader Peter Ben Embarek stating that it was very unlikely due to the safety protocols in place 81 During a 60 Minutes interview with Lesley Stahl Peter Daszak another member of the WHO team described the investigation process to be a series of questions and answers between the WHO team and the Wuhan lab staff Stahl made the comment that the team was just taking their word for it to which Daszak replied Well what else can we do There s a limit to what you can do and we went right up to that limit We asked them tough questions They weren t vetted in advance And the answers they gave we found to be believable correct and convincing 149 The investigation also stated that transfer from animals to humans was unlikely to have occurred at the Huanan Seafood Market since infections without a known epidemiological link were confirmed before the outbreak around the market 81 In an announcement that surprised some foreign experts the joint investigation concluded that early transmission via the cold chain of frozen products was possible 81 In March 2021 the WHO published a written report with the results of the study 150 The joint team stated that there are four scenarios for introduction 46 direct zoonotic transmission to humans spillover assessed as possible to likely introduction through an intermediate host followed by a spillover assessed as likely to very likely introduction through the cold food chain assessed as possible introduction through a laboratory incident assessed as extremely unlikely The report mentions that direct zoonotic transmission to humans has a precedent as most current human coronaviruses originated in animals Zoonotic transmission is also supported by the fact that RaTG13 binds to hACE2 although the fit is not optimal 4 151 The investigative team noted the requirement for further studies noting that these would potentially increase knowledge and understanding globally 152 4 9 Reactions WHO director general Tedros Adhanom who was not directly involved with the investigation said he was ready to dispatch additional missions involving specialist experts and that further research was required He said in a statement Some explanations may be more probable than others but for now all possibilities remain on the table 153 He also said We have not yet found the source of the virus and we must continue to follow the science and leave no stone unturned as we do Tedros called on China to provide more timely and comprehensive data sharing as part of future investigations 154 News outlets noted that though it was unrealistic to expect quick and huge results from the report it offered few clear cut conclusions regarding the start of the pandemic failed to audit the Chinese official position at some parts of the report and was biased according to critics 155 156 157 158 Other scientists praised how the report details the pathways that can shed light on the origin if explored later 159 After the publication of the report politicians talk show hosts journalists and some scientists advanced unsupported claims that SARS CoV 2 may have come from the WIV 160 In the United States calls to investigate a laboratory leak reached fever pitch fueling aggressive rhetoric resulting in antipathy towards people of Asian ancestry 160 161 and the bullying of scientists 162 163 164 The European Union United States and 13 other countries criticised the WHO convened study calling for transparency from China and access to the raw data and original samples 165 Chinese officials described these criticisms as an attempt to politicise the study 166 Scientists involved in the WHO report including Liang Wannian John Watson and Peter Daszak objected to the criticism and said that the report was an example of the collaboration and dialogue required to successfully continue investigations into the matter 167 In a letter published in Science a number of scientists including Ralph Baric argued that the accidental laboratory leak hypothesis had not been sufficiently investigated and remained possible calling for greater clarity and additional data 168 8 Their letter was criticized by some virologists and public health experts who said that a hostile and divisive focus on the WIV was unsupported by evidence and would cause Chinese scientists and authorities to share less rather than more data 160 Phase 2 See also Scientific Advisory Group for Origins of Novel Pathogens On 27 May 2021 Danish epidemiologist Tina Fischer spoke on the This Week in Virology podcast advocating for a second phase of the study to audit blood samples for COVID 19 antibodies in China 169 170 WHO convened study team member Marion Koopmans on that same broadcast advocated for WHO member states to make a decision on the second phase of the study though she also cautioned that an investigatory audit of the laboratory itself may be inconclusive 169 170 In early July 2021 WHO emergency chief Michael Ryan said the final details of phase 2 were being worked out in negotiations between WHO and its member states as the WHO works by persuasion and cannot compel any member state including China to cooperate 171 In July 2021 China rejected WHO requests for greater transparency cooperation and access to data as part of Phase 2 On 16 July 2021 Foreign Ministry spokesperson Zhao Lijian declared that China s position was that future investigations should be conducted elsewhere and should focus on cold chain transmission and the US military s labs 172 On 22 July 2021 the Chinese government held a press conference in which Zeng Yixin Vice Health Minister of the National Health Commission NHC said that China would not participate in a second phase of the WHO s investigation denouncing it as shocking and arrogant 132 He elaborated In some aspects the WHO s plan for next phase of investigation of the coronavirus origin doesn t respect common sense and it s against science It s impossible for us to accept such a plan 133 On 9 June 2022 the SAGO group in development of its function of advisor to the WHO published its first preliminary report This report summarised existing findings and recommended that further studies be undertaken into possibly pathways of emergence 134 The Lancet COVID 19 Commission task force In November 2020 Richard Horton editor of The Lancet appointed economist Jeffrey Sachs as chair of its COVID 19 Commission with wide ranging goals relating to the virus and pandemic 173 174 175 176 Sachs set up a number of task forces including one on the origins of the virus Sachs appointed Peter Daszak a colleague of Sachs at Columbia to head this task force two weeks after the Trump administration prematurely ended an federal grant supporting a project led by Daszak EcoHealth Alliance which worked with the Wuhan Institute of Virology 177 This appointment was criticised as creating a conflict of interest for instance by Richard Ebright chemical biologist at Rutgers University who called the commission an entirely Potemkin commission in the National Review 177 Daszak stated that the task force was formed to conduct a thorough and rigorous investigation into the origins and early spread of SARS CoV 2 The task force has twelve members with backgrounds in One Health outbreak investigation virology lab biosecurity and disease ecology 178 179 The task force planned to analyse scientific findings and did not plan to visit China 176 However as Sachs became increasingly drawn to the lab leak theory he came into conflict with Daszak and his task force 177 In June 2021 The Lancet announced that Daszak had recused himself from the commission 180 On 25 September 2021 the task force work was folded after procedural concerns and a need to broaden its scope to examine transparency and government regulation of risky laboratory research 181 However it continued to conduct its work independently 177 In September 2022 the Lancet commission published a wide ranging report on the pandemic including commentary on the virus origin overseen by the group s chairman economist Jeffrey Sachs 182 The report suggested that the virus may have originated from an American laboratory a notion promoted by Sachs since late 2020 including in 2022 on the podcast of anti vaxx conspiracy theorist Robert F Kennedy Jr 177 183 184 Reacting to the Commission report virologist Angela Rasmussen commented that this may have been one of The Lancet s most shameful moments regarding its role as a steward and leader in communicating crucial findings about science and medicine 184 Virologist David Robertson said the invocation of US laboratory involvement was wild speculation and that it s really disappointing to see such a potentially influential report contributing to further misinformation on such an important topic 184 The task force published their own report in October 2022 saying they concluded there was overwhelming evidence of a natural spillover but they also accepted the possibility of a lab leak 177 185 Independent investigations In June 2021 the NIH announced that a set of sequence data had been removed from the Sequence Read Archive SRA in June 2020 The removal was performed according to standard practice at the request of the investigators who owned the rights to the sequences with the investigators rationale that the sequences would be submitted to another database 186 187 The investigators subsequently published a paper in an academic journal the same month they were removed from the NIH database which described the sequences in detail and discussed their evolutionary relationship to other sequences but did not include the raw data 188 Virologist David Robertson said that it was difficult to conclude it was a cover up rather than the more likely explanation a mundane deletion of data without malfeasance 189 190 The missing genetic sequence data was restored in a correction published 29 July 2021 after it was stated to be a copy edit error 191 192 In March 2023 an international team of virus experts from University of Arizona Scripps Research Institute and University of Sydney found genetic evidence that COVID 19 may have originated from the illegal trade of infected raccoon dogs in Wuhan China supporting the zoonotic transmission scenario Swabs taken from the Huanan Seafood Wholesale Market in January 2020 which tested positive for coronavirus contained large amounts of genetic material from raccoon dogs 193 International calls for investigations In April 2020 Australian foreign minister Marise Payne and Australian prime minister Scott Morrison called for an independent international inquiry into the origins of the coronavirus pandemic 194 195 A few days later German chancellor Angela Merkel also pressed China for transparency about the origin of the coronavirus following similar concerns raised by the French president Emmanuel Macron 196 The UK also expressed support for an investigation although both France and UK said the priority at the time was to first fight the virus 197 198 Some public health experts have also called for an independent examination of COVID 19 s origins arguing WHO does not have the political clout to conduct such a forensic analysis 199 In May 2021 Prime Minister Justin Trudeau told reporters Canada would support the call by the United States and others to better understand the origins of COVID 19 200 201 In June 2021 at the G7 summit in Cornwall the attending leaders issued a joint statement calling for a new investigation citing China s refusal to cooperate with certain aspects of the original WHO convened study 202 This resistance to international pressure was one of the key findings of a Wall Street Journal investigation into the pandemic origin 203 The divisive nature of the debate has led scientists to call for less political pressure on the topic 112 Public health analysts have remarked that the debate over the origins of SARS CoV 2 is fueling unnecessary confrontation resulting in bullying and harassment of scientists 204 and is deepening existing geopolitical tensions and hindering collaboration at a time where such mutual cooperation is required both to deal with the current pandemic and in preparation for future such outbreaks 205 206 This comes in the face of scientists having predicted such events for decades according to Katie Woolaston researcher at the Queensland University of Technology The environmental drivers of pandemics are not being widely discussed The debate comes at a moment of difficult global relations with Chinese authorities Researchers have noted that the politicisation of the debate is making the process more difficult and that words are often twisted to become fodder for conspiracy theories 207 208 A letter published in The Lancet in July 2021 remarked that the atmosphere of speculation surrounding the issue was of no help in making an objective assessment of the situation 209 In response to this letter in a communication published in the same journal a small group of researchers opposed the idea that scientists should promote unity and called for openness to alternative hypotheses 210 Despite the unlikelihood of the event and although definitive answers are likely to take years of research biosecurity experts have called for a review of global biosecurity policies citing known gaps in international standards for biosafety 205 207 The situation has also reignited a debate over gain of function research although the intense political rhetoric surrounding the issue has threatened to sideline serious inquiry over policy in this domain 211 See alsoAssessment on COVID 19 Origins Proximal Origin Scientific Advisory Group for Origins of Novel Pathogens World Health Organization s response to the COVID 19 pandemicReferences Aguirre A Alonso Catherina Richard Frye Hailey Shelley Louise September 2020 Illicit Wildlife Trade Wet Markets and COVID 19 Preventing Future Pandemics World Medical amp Health Policy 12 3 256 265 doi 10 1002 wmh3 348 ISSN 1948 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S2CID 221614695 Retrieved 24 May 2023 Individuals may learn about the origins of COVID 19 through exposure to stories that communicate either what most scientists believe i e zoonotic transmission or through exposure to conspiratorial claims e g the virus was created in a research laboratory in China Robertson Lori 2 March 2023 Still No Determination on COVID 19 Origin FactCheck org Retrieved 24 May 2023 most scientists suspect a zoonotic spillover in which the virus transferred from bats or through an intermediate animal to humans the same way the SARS and MERS coronaviruses originated Gajilan A Chris 19 September 2021 Covid 19 origins Why the search for the source is vital CNN Retrieved 24 May 2023 The zoonotic hypothesis hinges on the idea that the virus spilled over from animals to humans either directly through a bat or through some other intermediary animal Most scientists say that this is the likely origin given that 75 of all emerging diseases have jumped from animals into humans McDonald Jessica 28 June 2021 Where Did COVID 19 Start The Facts and Mysteries of Its Origin NBC 5 Dallas Fort Worth Retrieved 24 May 2023 The default answer for most scientists has been that the virus SARS CoV 2 probably made the jump to humans from bats if it was a direct spillover or more likely through one or more intermediate mammals MCKEEVER AMY 6 April 2021 We still don t know the origins of the coronavirus Here are 4 scenarios National Geographic Retrieved 24 May 2023 The most controversial hypothesis for the origin of SARS CoV 2 is also the one that most scientists agree is the least likely that the virus somehow leaked out of a laboratory in Wuhan where researchers study bat coronaviruses Ball Philip Three years on Covid lab leak theories aren t going away This is why www prospectmagazine co uk The leading theory now backed by most scientists is that the virus arose in wild bats and found its way into animals perhaps via a pangolin or a civet cat sold at the Huanan Seafood Wholesale Market in Wuhan Jackson Christina 21 September 2020 Controversy Aside Why the Source of COVID 19 Matters GEN Genetic Engineering and Biotechnology News Retrieved 24 May 2023 Most scientists studying the origins of COVID 19 have concluded that the SARS CoV 2 virus probably evolved naturally and infected humans via incidental contact with a wild or domesticated animal McCarthy Simone 16 September 2021 Bat human virus spillovers may be very common study finds South China Morning Post Retrieved 24 May 2023 Questions have been raised about whether the virus could have leaked from a laboratory studying related viruses in Wuhan a scenario most scientists feel is less likely than a natural spillover Danner Chas 26 May 2021 Biden Joins the COVID Lab Leak Theory Debate Intelligencer Retrieved 24 May 2023 There continues to be no evidence at all for the conspiracy theory that SARS CoV 2 the virus that causes COVID 19 was developed as some kind of bioweapon and most scientists 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