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Wikipedia

Mephedrone

January 01, 1970

Not to be confused with methedrine, methedrone, mephedrene, methadone, methylone, methcathinone, or ephedrone.

Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone,[5] M-CAT,[6] White Magic,[7] meow meow and bubble.[8] It is chemically similar to the cathinone compounds found in the Khat plant of eastern Africa.[5][9] It comes in the form of tablets or crystals,[10] which users can swallow, snort or inject, producing effects similar to those of MDMA, amphetamines and cocaine.

Mephedrone
Clinical data
Other names4-methyl-N-methylcathinone; 2-methylamino-1-p-tolylpropan-1-one[1]
Routes of
administration		Oral, insufflation, IV, rectal
ATC code
  • none
Legal status
Legal status
Identifiers
  • (RS)-2-Methylamino-1-(4-methylphenyl)propan-1-one[4]: 5 
CAS Number
  • 1189805-46-6 N
    1189726-22-4 (HCl)[4]: 5 
PubChem CID
  • 29982893
ChemSpider
  • 21485694 Y
UNII
  • 8BA8T27317
KEGG
  • C22785
ChEBI
  • CHEBI:59331 Y
CompTox Dashboard (EPA)
  • DTXSID20891437
ECHA InfoCard100.189.720
Chemical and physical data
FormulaC11H15NO
Molar mass177.247 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC1=CC=C(C(C(NC)C)=O)C=C1
  • InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3 Y
  • Key:YELGFTGWJGBAQU-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

In addition to its stimulant effects, mephedrone produces side effects, of which bruxism is the most common. The metabolism of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage.

Mephedrone was first synthesised in 1929, but did not become widely known until it was rediscovered in 1999–2000 at which point it was legal to produce and possess in many countries. By 2000, mephedrone was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010, it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. Mephedrone was first made illegal in Israel in 2008, followed by Sweden later that year. In 2010, it was made illegal in many European countries and in December 2010, the EU ruled it illegal. In Australia, New Zealand and the United States, it is considered an analog of other illegal drugs and can be controlled by laws similar to the US Federal Analog Act. In September 2011, the US temporarily classified mephedrone as a Schedule I drug, effective October 2011. This classification was made permanent in July 2012 with the passage of the Synthetic Drug Abuse Prevention Act (SDAPA).

Uses edit

Recreational edit

Users have reported that mephedrone causes euphoria, stimulation, an enhanced appreciation for music, an elevated mood, decreased hostility, improved mental function and mild sexual stimulation; these effects are similar to the effects of cocaine, amphetamines and MDMA, and last different lengths of time depending on the way the drug is taken. Of 70 Dutch users of mephedrone, 58 described it as an overall pleasant experience and 12 described it as an unpleasant experience.[11] In a survey of UK users who had previously taken cocaine, most users found it produced a better-quality and longer-lasting high and was less addictive. The users were also asked to compare the "risk", and they answered that it was equal.[12] A study of users in Northern Ireland found they did not equate the fact that mephedrone was legal with it being safe to use. This was contrary to another study in New Zealand, where users of benzylpiperazine thought that because it was legal, it was safe.[13]

Available forms edit

Mephedrone can come in the form of capsules, tablets or white powder that users may swallow, snort, inject, smoke or use rectally.[4]: 12 [12][14] When taken orally, users reported they could feel the effects within 15–45 minutes; when snorted, the effects were felt within minutes and peaked within half an hour. The effects last for between two and three hours when taken orally or nasally, but only half an hour if taken intravenously.[4]: 12  It is sometimes sold mixed with methylone in a product called bubbles in the UK[15] and also mixed with other cathinones, including ethcathinone, butylone, fluoromethcathinone and methedrone.[4]: 9 

Purity edit

One published study that analysed samples of mephedrone bought using the internet in the UK in 2010 found it was racemic (a mixture of both stereoisomers) and of high purity.[16] An unpublished study of six samples also ordered off the internet in the UK in 2010 found they contained very few organic impurities.[17] Four products sold in Irish head shops were tested in 2010 and were found to contain between 82% and 14% mephedrone, with some products containing benzocaine and caffeine.[18]

Adverse effects edit

 
Table from the 2010 ISCD study ranking various drugs (legal and illegal) based on statements by drug-harm experts. Mephedrone was found to be the 13th overall most dangerous drug.[19]

Short-term effects edit

The EMCDDA reported mephedrone can cause various unintended side effects including: dilated pupils,[20] poor concentration, teeth grinding, problems focusing visually, poor short-term memory, hallucinations, delusions, and erratic behaviour.[4]: 13  They noted the most severe effects appear anecdotally to be linked with high doses or prolonged use, and the effects may be due to users taking other intoxicants at the same time. Other effects users in internet forums have noted include changes in body temperature, increased heart rate, breathing difficulties, loss of appetite, increased sweating, discolouration of extremities, anxiety, paranoia and depression.[4]: 13  When snorted, it can also cause nose bleeds and nose burns.[4]: 13 [21] A survey conducted by the UK National Addiction Centre found 67% of mephedrone users experienced sweating, 51% suffered from headaches, 43% from heart palpitations, 27% from nausea and 15% from cold or blue fingers,[22] indicative of vasoconstriction occurring.[23] Doctors at Guy's Hospital in London reported that of 15 patients they treated after taking mephedrone in 2009, 53% were agitated, 40% had increased heart rates, 20% had systolic hypertension and 20% had seizures; three required treatment with benzodiazepines, predominantly to control their agitation. They reported none of their patients suffered from cold or blue peripheries, contrary to other reports. Nine of the 15 of patients had a Glasgow coma scale (GCS) of 15, indicating they were in a normal mental state, four had a GCS below 8, but these patients all reported using a central nervous system depressant, most commonly GHB, with mephedrone. The patients also reported polydrug use of a variety of compounds.[24]

Neurotoxicity edit

Mephedrone is neurotoxic and induces injury to the 5-HT neurons.[25][26][27] Although some studies in animal models reported no damage to DA nerve endings in the striatum and no significant changes in brain monoamine levels, some others suggested a rapid reduction in 5-HT and DA transporter function. Persistent serotonergic deficits were observed after binge like treatment in a warm environment and in both serotonergic and dopaminergic nerve endings at high ambient temperature. Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported.[26][28]

Reinforcement disorders edit

There have been reports of users craving mephedrone, suggesting it may be addictive.[4]: 13 [11]

Overdose edit

Toxicity edit

In 2009, one case of sympathomimetic toxicity was reported in the UK after a person took 0.2 g of mephedrone orally, and after this did not achieve the desired effect, intramuscularly injected 3.8 g mixed with water into his thighs. Shortly afterwards, the user "developed palpitations, blurred tunnel vision, chest pressure and sweating". The patient was treated with 1 mg of lorazepam and the sympathomimetic features decreased and the user was discharged within six hours of arrival.[29] One case of serotonin syndrome has been reported, where the patient was already prescribed fluoxetine and olanzapine, and then took 40 tablets containing mephedrone in one night. He was treated with lorazepam and discharged 15 hours after admission.[30] Both enantiomers of methcathinone, which differs only in the lack of the methyl group on the aryl ring when compared to mephedrone, have been shown to be toxic to rat dopamine neurons, and the S-enantiomer was also toxic against serotonin neurons. Simon Gibbons and Mire Zloh of the School of Pharmacy, University of London stated, based on the chemical similarities between methcathinone and mephedrone, "it is highly likely that mephedrone will display neurotoxicity".[16] However, Brunt and colleagues stated, "extreme caution" should be used when inferring the toxicity of mephedrone from methcathinone, noting some of the toxicity associated with methcathinone is due to manganese impurities related to its synthesis, rather than the compound itself. They concluded more experimental research is needed to investigate the toxicity of mephedrone.[11]

Doctors who treated a 15-year-old female suffering from mephedrone intoxication suggested in The Lancet that, like MDMA, mephedrone may promote serotonin-mediated release of antidiuretic hormone, resulting in hyponatraemia and an altered mental state.[31] In another case, a 19-year-old male was admitted to hospital suffering from inflammation of the heart, 20 hours after taking one gram of mephedrone. The doctors treating the patient stated it was caused by either a direct toxic effect of mephedrone on the heart muscle, or by an immune response.[32] One case of acquired methaemoglobinaemia, where a patient had "bluish lips and fingers", has also been reported, after the user snorted one gram of mephedrone. The patient started to recover after arriving at the hospital and it was not necessary to administer any medication.[33]

Deaths edit

Sweden edit

In 2008, an 18-year-old Swedish woman died in Stockholm after taking mephedrone. The newspaper Svenska Dagbladet reported the woman went into convulsions and turned blue in the face.[34] Doctors reported she was comatose and suffering from hyponatremia and severe hypokalemia; the woman died one and a half days after the onset of symptoms. An autopsy showed severe brain swelling.[35] Mephedrone was scheduled to be classified as a "dangerous substance" in Sweden even before the woman's death at Karolinska University Hospital on 14 December, but the death brought more media attention to the drug. The possession of mephedrone became classified as a criminal offence in Sweden on 15 December 2008.[34]

United Kingdom edit

In 2010, unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK. By July 2010, mephedrone had been alleged to be involved in 52 fatalities in the UK, but detected in only 38 of these cases. Of the nine that coroners had finished investigating, two were caused directly by mephedrone.[36] The first death reported to be caused by mephedrone use was that of 46-year-old, John Sterling Smith,[37] who had underlying health problems and repeatedly injected the drug.[38] A report in Forensic Science International in August 2010 stated mephedrone intoxication has been recorded as the cause of death in two cases in Scotland. Post mortem samples showed the concentration of mephedrone in their blood was 22 mg/L in one case and 3.3 mg/L in the other.[39] The death of a teenager in the UK in November 2009 was widely reported as being caused by mephedrone, but a report by the coroner concluded she had died from natural causes.[40] In March 2010, the deaths of two teenagers in Scunthorpe were widely reported by the media to be caused by mephedrone. Toxicology reports showed the teenagers had not taken any mephedrone and had died as a result of consuming alcohol and the synthetic opioid agonist methadone.[38][41] According to Fiona Measham, a criminologist who is a member of the ACMD, the reporting of the unconfirmed deaths by newspapers followed "the usual cycle of 'exaggeration, distortion, inaccuracy and sensationalism'" associated with the reporting of recreational drug use.[42]

United States edit

Mephedrone has been implicated in the death of a 22-year-old man, who had also injected black tar heroin. Mephedrone was found in his blood at a concentration of 0.50 mg/L and in his urine at a concentration of 198 mg/L. The blood concentration of morphine, a metabolite of heroin, was 0.06 mg/L.[43] For comparison, the average blood morphine concentration resulting from deadly overdoses involving only heroin is around 0.34 mg/L.[44]

Pharmacology edit

Pharmacodynamics edit

Mephedrone is a monoamine releasing agent. It is a chiral compound and both of its enantiomers display similar potency as substrates at dopamine transporters. R-Mephedrone is much less potent than S-mephedrone as a substrate at serotonin transporters.[45]

The keto oxygen renders mephedrone more hydrophilic than the corresponding amphetamine 4-Methylmethamphetamine, which may account for the higher doses required to achieve a similar effect, because mephedrone is less able to cross the blood–brain barrier.[4]: 12 [16]

Mephedrone is often consumed with alcohol. A study in mice investigated the interrelation between these two substances, focusing on the psychostimulant and rewarding properties of mephedrone. It found that at low (non-stimulant) doses alcohol significantly enhanced the psychostimulant effects of mephedrone. This effect was mediated by an increase in synaptic dopamine, as haloperidol, but not ketanserin, was able to block the potentiation by alcohol. Similarly, the rewarding properties of mephedrone were enhanced by a low non-rewarding dose of alcohol.[46]

Pharmacokinetics edit

Several articles published near the end of 2011 examined the effects of mephedrone, compared to the similar drugs MDMA and amphetamine in the nucleus accumbens of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured using HPLC. Reward and drug seeking are linked to increases in dopamine concentrations in the nucleus accumbens, and drug half-life plays a role in drug seeking, as well. Based on histological examination, most of the author's probes were in the nucleus accumbens shell. Mephedrone administration caused about a 500% increase in dopamine, and about a 950% increase in serotonin. They reached their peak concentrations at 40 minutes and 20 minutes, respectively, and returned to baseline by 120 minutes after injection. In comparison, MDMA caused a roughly 900% increase in serotonin at 40 minutes, with an insignificant increase in dopamine. Amphetamine administration resulted in about a 400% increase in dopamine, peaking at 40 minutes, with an insignificant increase in serotonin. Analysis of the ratio of the AUC for dopamine (DA) and serotonin (5-HT) indicated mephedrone was preferentially a serotonin releaser, with a ratio of 1.22:1 (serotonin vs. dopamine). Additionally, half-lives for the decrease in DA and 5-HT were calculated for each drug. Mephedrone had decay rates of 24.5 minutes and 25.5 minutes, respectively. MDMA had decay values of 302.5 minutes and 47.9 minutes, respectively, while amphetamine values were 51 minutes and 84.1 minutes, respectively. Taken together, these findings show mephedrone induces a massive increase in both DA and 5-HT, combined with rapid clearance. The rapid rise and subsequent fall of DA levels could explain some of the addictive properties mephedrone displays in some users.[47][48]

Metabolism edit

Based on the analysis of rat and human urine by gas chromatography and mass spectrometry, mephedrone is thought to be metabolised by three phase 1 pathways. It can be demethylated to the primary amine (producing compounds 2, 3 and 5), the ketone group can be reduced (producing 3) or the tolyl group can be oxidised (producing 6). Both 5 and 6 are thought to be further metabolised by conjugation to the glucuronide and sulfate derivatives. Knowledge of the primary routes of metabolism should allow the intake of mephedrone to be confirmed by drug tests, as well as more accurate determination of the causes of side effects and potential for toxicity.[49]

 
Proposed scheme for the metabolism of mephedrone (1) based on the analysis of rat and human urine[49]

Detection in body fluids edit

Mephedrone may be quantitated in blood, plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalised patients or to provide evidence in a medicolegal death investigation. Blood or plasma mephedrone concentrations are expected to be in a range of 50–100 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients and >500 μg/L in victims of acute overdosage.[50][51]

Chemistry edit

Appearance and odour edit

Mephedrone is a white substance. It is sold most commonly as crystals or a powder, but also in the form of capsules or pills.[52][53] It can have a distinctive odour, reported to range the smell of vanilla and bleach, stale urine, or electric circuit boards.[54] Synthesis byproducts or other contaminants are likely responsible for this, as the molecule itself is not an odorant.

Synthesis edit

Mephedrone can be synthesised in several ways. The simplest method, due to the availability of the compounds,[4]: 17  is to add 4-methylpropiophenone dissolved in glacial acetic acid to bromine, creating an oil fraction of 4'-methyl-2-bromopropiophenone. The oil fraction can then be dissolved in dichloromethane (CH2Cl2) and drops of the solution added to another solution of CH2Cl2-containing methylamine hydrochloride and triethylamine. Hydrochloric acid (HCl) is then added and the aqueous layer is removed and turned alkaline using sodium hydroxide before the amine is extracted using CH2Cl2. The CH2Cl2 is then evaporated using a vacuum, creating an oil which is then dissolved in a nonaqueous ether. Finally, HCl gas is bubbled through the mixture to produce 4-methylmethcathinone hydrochloride.[55] This method produces a mixture of both enantiomers and requires similar knowledge to that required to synthesise amphetamines and MDMA.[4]: 17 

 
Mephedrone synthesis scheme from 4-methylpropiophenone

It can also be produced by oxidising the ephedrine analogue 4-methylephedrine using potassium permanganate dissolved in sulfuric acid. Because 4-methylephedrine can be obtained in a specific enantiomeric form, mephedrone consisting of only one enantiomer can be produced. The danger associated with this method is it may cause manganese poisoning if the product is not correctly purified.[4]: 17 

Analysis edit

Mephedrone does not react with most reagent testing kits. The exception is the Liebermann reagent, which gives a bright yellow reaction.[56]

History edit

 
Mephedrone. "Not for human consumption. For technical use only. Purity: 99+ %"

Mephedrone is one of hundreds of designer drugs or legal highs that have been reported in recent years, including artificial chemicals such as synthetic cannabis and semisynthetic substances such as methylhexanamine. These drugs are primarily developed to avoid being controlled by laws against illegal drugs, thus giving them the label of designer drugs.[13] According to the European Monitoring Centre for Drugs and Drug Addiction, the synthesis of mephedrone was first reported in 1929 by Saem de Burnaga Sanchez in the Bulletin de la Société Chimique de France, under the name "toluyl-alpha-monomethylaminoethylcetone",[4]: 17 [57] but the compound remained an obscure product of academia until 2003, when it was "re-discovered" and publicised by an underground chemist on The Hive website, registered to a Portuguese IP working under the pseudonym "Kinetic".[58] Kinetic posted on the site, "I've been bored over the last couple of days and had a few fun reagents lying around, so I thought I'd try and make some 1-(4-methylphenyl)-2-methylaminopropanone hydrochloride, or 4-methylmethcathinone." before going on to describe that after consuming it, the user had a "fantastic sense of well-being that I haven't got from any drug before except my beloved Ecstasy."[59] After the initial description of mephedrone's qualitative effects by Kinetic, the drug was commercially introduced in Israel by a mathematician named Ezekiel Golan or "Dr. Z".[60][61]

A drug similar to mephedrone, containing cathinone, was sold legally in Israel from around 2004, under the name hagigat. When this was made illegal, the cathinone was modified and the new products were sold by the Israeli company, Neorganics.[62][63][64] The products had names such as Neodoves pills, but the range was discontinued in January 2008 after the Israeli government made mephedrone illegal.[5][55][65] The Psychonaut Research Project, an EU organisation that searches the internet for information regarding new drugs, first identified mephedrone in 2008. Their research suggested the drug first became available to purchase on the internet in 2007, made available through British contacts, contact unknown, when it was also discussed on internet forums.[13][66] Mephedrone was first seized in France in May 2007, after police sent a tablet they assumed to be ecstasy to be analysed, with the discovery published in a paper titled "Is 4-methylephedrone, an "Ecstasy" of the twenty-first century?"[53] Mephedrone was reported as having been sold as ecstasy in the Australian city of Cairns, along with ethylcathinone, in 2008.[67][68] An annual survey of regular ecstasy users in Australia in 2010 found 21% of those surveyed had used mephedrone, with 17% having done so in the previous six months. The price they paid per gram varied from A$16 to $320.[14]

Europol noted they became aware of it in 2008, after it was found in Denmark, Finland and the UK.[69] The Drug Enforcement Administration noted it was present in the United States in July 2009.[70] By May 2010, mephedrone had been detected in all 22 EU member states that reported to Europol, as well as in Croatia and Norway.[4]: 21  The Daily Telegraph reported in April 2009 that it was manufactured in China, but it has since been made illegal there.[71][72] In March 2009, Druglink magazine reported it only cost a "couple of hundred pounds" to synthesise a kilogram of mephedrone,[62] the same month, The Daily Telegraph reported manufacturers were making "huge amounts of money" from selling it.[73] In January 2010, Druglink magazine reported dealers in Britain spent £2,500 to ship one kilogram from China, but could sell it for £10 a gram, making a profit of £7,500.[59][74] A later report, in March 2010, stated the wholesale price of mephedrone was £4000 per kilogram.[75]

In March 2011, the International Narcotics Control Board published a report about designer drugs, noting mephedrone was by then being used recreationally in Europe, North America, Southeast Asia, New Zealand and Australia.[76][77]

United Kingdom edit

 
The number of samples analysed by the Forensic Science Service of seized MDMA, piperazines and cathinones between the third quarter of 2005 and the first quarter of 2010: MDMA seizures in blue, piperazine seizures in orange and cathinone seizures in purple[78]

Between the summer of 2009 and March 2010, the use of mephedrone grew rapidly in the UK, with it becoming readily available at music festivals, head shops and on the internet.[42] A survey of Mixmag readers in 2009, found it was the fourth most popular street drug in the United Kingdom, behind cannabis, cocaine, and ecstasy.[75] The drug was used by a diverse range of social groups. Whilst the evidence was anecdotal, researchers, charity workers, teachers and users reported widespread and increasing use of the drug in 2009. The drug's rapid growth in popularity was believed to be related to both its availability and legality.[42] In a book about drugs[79] David Nutt reports the re-popularization story of mephedrone in a way that can be cross referenced with a report by Chemistry World in an article.[80]

Fiona Measham, a criminologist at The University of Lancaster, thought the emergence of mephedrone was also related to the decreasing purity of ecstasy and cocaine on sale in the UK,[42] a view reinforced in a report by the National Treatment Agency for Substance Misuse.[81] The average cocaine purity fell from 60% in 1999 to 22% in 2009 and about half of ecstasy pills seized in 2009 contained no MDMA,[82] and by June 2010 almost all ecstasy pills seized in the UK contained no MDMA.[83] A similar pattern was observed in the Netherlands, with the number of ecstasy tablets containing no MDMA rising from 10% in mid-2008 to 60% by mid-2009, with mephedrone being detected in 20% of ecstasy tablets by mid-2009.[11] The decrease of MDMA was thought to be partly due to the seizure of 33 tonnes of sassafras oil, the precursor to MDMA, in Cambodia in June 2008, which could have been used to make 245 million doses of MDMA.[59] According to John Ramsey, a toxicologist at St George's, University of London, the emergence of mephedrone was also related to the UK government banning the benzylpiperazine class of drugs in December 2009.[62][84] gamma-Butyrolactone (GBL), another previously "legal high", was also banned in August 2009 despite concerns it would be replaced by other drugs.[85]

By December 2009 mephedrone was available on at least 31 websites based in the UK and by March 2010 there were at least 78 online shops, half of which sold amounts of less than 200 grams and half that also sold bulk quantities. The price per gram varied from £9.50 to £14.[4]: 11  Between July 2009 and February 2010, UK health professionals accessed the National Poisons Information Service's (NPIS) entry on mephedrone 1664 times and made 157 telephone inquiries; the requests increased month on month over this period. In comparison, over a similar time period, the entries for cocaine and MDMA were accessed approximately 2400 times.[23] After mephedrone was made illegal the number of inquiries to the NPIS fell substantially, to only 19 in June 2010.[86]

Media organisations including the BBC and The Guardian incorrectly reported mephedrone was commonly used as a plant fertiliser. In fact sellers of the drug described it as "plant food" because it was illegal to sell the compound for human consumption.[82] In late 2009 UK newspapers began referring to the drug as meow or miaow (sometimes doubled as meow meow or miaow miaow), a name that was almost unknown on the street at the time.[87] In November 2009, the tabloid newspaper, The Sun published a story stating that a man had ripped off his own scrotum whilst using mephedrone. The story was later shown to be an online joke posted on mephedrone.com, later included in a police report with the caveat that it could be unreliable. The police report was used as a source for the story in The Sun.[40][88] Other myths the media often repeated during 2010 were that mephedrone had led to the deaths of over 20 people, teachers were unable to confiscate the drug from pupils and the government was too slow to ban the drug.[89] Parallels were drawn between the media coverage of mephedrone and a piece of satire by Chris Morris in 1997 on Brass Eye when he tricked public figures into talking of the dangers of taking the fictional legal drug "cake".[40] The Advisory Council on the Misuse of Drugs (ACMD) have suggested that the media coverage of the drug led to its increased usage.[90] Jon Silverman, a former BBC Home Affairs Correspondent, has written two articles discussing how the media had a strong influence over the UK government's drugs policy, particularly in that the government wished to demonstrate they were being "tough" on drugs.[85][91]

A survey of 1000 secondary school pupils and university students in Tayside conducted in February 2010 found 20% of them had previously taken mephedrone. Although at the time it was available legally over the internet, only 10% of users reported purchasing it online, with most purchasing it from street dealers. Of those who had used mephedrone, 97% said it was easy or very easy to obtain. Around 50% of users reported at least one negative effect associated with the use of mephedrone, of which teeth grinding is the most common.[92] Detailed interviews with users in Northern Ireland similarly found that few purchased mephedrone online, with most interviewees citing concerns that their address would be traced or that family members could intercept the package.[13]

On 30 March 2010, Alan Johnson, the then Home Secretary, announced mephedrone would be made illegal "within weeks" after the ACMD sent him a report on the use of cathinones.[9][93] The legislation would make all cathinones illegal, which Johnson said would "stop unscrupulous manufacturers and others peddling different but similarly harmful drugs".[94] The ACMD had run into problems with the UK Government in 2009 regarding drugs policy, after the government did not follow the advice of the ACMD to reclassify ecstasy and cannabis, culminating in the dismissal of the ACMD chairman, David Nutt, after he reiterated the ACMD's findings in an academic lecture.[95] Several members resigned after he was sacked, and prior to the announcement that mephedrone was to be banned, the trend continued when Dr Polly Taylor resigned, saying she "did not have trust" in the way the government would use the advice given by the ACMD.[96] Eric Carlin, a member of the ACMD and former chairman of the English Drug Education Forum, also resigned after the announcement. He said the decision by the Home Secretary was "unduly based on media and political pressure" and there was "little or no discussion about how our recommendation to classify this drug would be likely to impact on young people's behaviour."[97] Some former members of the ACMD and various charity groups expressed concern over the banning of the drug, arguing it would inevitably criminalise users, particularly young people.[98] Others expressed concern that the drug would be left in the hands of black market dealers, who will only compound the problem.[99] Carlin's resignation was specifically linked to the criminalisation of mephedrone; he stated: "We need to review our entire approach to drugs, dumping the idea that legally-sanctioned punishments for drug users should constitute a main part of the armoury in helping to solve our country's drug problems. We need to stop harming people who need help and support".[100]

The parliamentary debate was held on 8 April, one day after the 2010 general election had been announced, meaning it was during the so-called "wash-up period" when legislation is passed with little scrutiny. Only one hour was spent debating the ban and all three parties agreed, meaning no vote was required.[101] In an interview conducted in July 2010, when he was no longer a minister, Johnson admitted the decision to ban mephedrone was sped up after widespread reporting of deaths caused by the drug, and because the government wished to pass the law before parliament was dissolved prior to the upcoming general election.[85] In January 2011, however, Johnson told the Scunthorpe Telegraph that the decision was based only on information from the ACMD.[102] An editorial in the April 2010 edition of The Lancet questioned the decision to ban mephedrone, saying the ACMD did not have enough evidence to judge the potential harms caused by mephedrone and arguing that policy makers should have sought to understand why young people took it and how they could be influenced to not take it.[90] Evan Harris, then the Liberal Democrat science spokesman, stated the ACMD "was not 'legally constituted'" as required by the Misuse of Drugs Act, when the report on cathinones was published, since after Taylor resigned, it lacked a veterinary surgeon.[94] In the rush to make mephedrone illegal, the act that was passed specified the inactive enantiomer of mephedrone, leaving the active form legal until the loophole was closed in February 2011 by another act of parliament.[103] In Chemistry World, John Mann, professor of chemistry at Queen's University Belfast, suggested the UK create a law similar to the Federal Analog Act of the United States, which would have made mephedrone illegal as an analog of cathinone.[104] In August 2010, James Brokenshire, the Home Office drugs minister, announced plans to create a new category in the Misuse of Drugs Act, through the Police Reform and Social Responsibility Bill, that would allow new legal highs to be made temporarily illegal, without the need for a vote in parliament or advice from the ACMD, as was required to categorise mephedrone.[105][106][107]

According to the Independent Scientific Committee on Drugs, after mephedrone was made illegal, a street trade in the drug emerged, with prices around double those prior to the ban, at £20–£25 per gram.[108] In September 2010, Druglink reported the ban had a mixed effect on mephedrone use, with it decreasing in some areas, remaining similar in others and becoming more prevalent in some areas.[109] In an online survey of 150 users after the ban, 63% said they were continuing to use mephedrone; of those, half claimed unchanged usage amounts (as to dosage and frequency) and half claimed decreased usage. Compared to previous surveys, more users purchased it from dealers, rather than the internet. The average price per gram was £16, compared to around £10 before the ban.[110] The 2010 Mixmag survey of 2,500 nightclubbers found one quarter had used mephedrone in the previous month, the price had roughly doubled since it was made illegal, and it was more likely to be cut with other substances.[111] Of those who had already used mephedrone prior to the ban, 75% had continued to use it after the ban. Of the various drugs used by the survey participants, users were more likely to have concerns about it.[112] Interviews with users in Northern Ireland also found the price had roughly doubled since it was made illegal, to around £30 a gram. Rather than the price rising due to increased scarcity of the drug, it is thought to have risen for two other reasons. Firstly, dealers knew there was still demand for mephedrone, but were aware the supplies may be exhausted in the future. Secondly, the dealers perceived customers were likely to be willing to pay more for an illegal substance.[13]

Professor Shiela Bird, a statistician at the Medical Research Council, suggested the ban of mephedrone may lead to more cocaine-related deaths. In the first six months of 2009, the number of cocaine-related deaths fell for the first time in four years, and fewer soldiers tested positive for cocaine in 2009 than in 2008. She suggested this may have been due to users switching to mephedrone from cocaine, but cautioned that before full figures are available for 2009 and 2010, it will be difficult to determine whether mephedrone saved lives, rather than cost them.[113][114] Other supposedly legal drugs have filled the gap in the market since mephedrone was made illegal, including naphyrone (NRG-1) (since made illegal)[115] and Ivory Wave, which has been found to contain MDPV, a compound made illegal at the same time as mephedrone. However, some products branded as Ivory Wave possibly do not contain MDPV.[116] When tested, some products sold six weeks after mephedrone was banned, advertised as NRG-1, NRG-2 and MDAI, were found to be mephedrone.[117] A Drugscope survey of drugs workers at the end of 2012 reported that mephedrone use was still widespread in the UK and that there increasing reports of problematic users. It was being taken as not only a "poor man's cocaine" but also amongst users of heroin and crack cocaine. Cases of intravenous use were also reported to be on the increase.[118]

Society and culture edit

Legal status edit

 
A sample of mephedrone that was confiscated in Oregon, US, 2009

When mephedrone was rediscovered in 2003, it was not specifically illegal to possess in any country. As its use has increased, many countries have passed legislation making its possession, sale and manufacture illegal. It was first made illegal in Israel, where it had been found in products such as Neodoves pills, in January 2008.[5] After the death of a young woman in Sweden in December 2008 was linked to the use of mephedrone, it was classified as a hazardous substance a few days later, making it illegal to sell in Sweden. In June 2009, it was classified as a narcotic with the possession of 15 grams or more resulting in a minimum of two years in prison—a longer sentence, gram for gram than given for the possession of cocaine or heroin.[119][120] In December 2008, Denmark also made it illegal[121] and through the Medicines Act of Finland, it was made illegal to possess without a prescription.[122] In November 2009, it was classified as a "narcotic or psychotropic" substance and added to the list of controlled substances in Estonia[123] and made illegal to import into Guernsey along with other legal highs,[124] before being classified as a Class B drug in April 2010.[125] It was classified as a Class C drug in Jersey in December 2009.[126]

In 2010, as its use became more prevalent, many countries passed legislation prohibiting mephedrone. It became illegal in Croatia[127] and Germany[128] in January, followed by Romania[129] and the Isle of Man in February.[130] In March 2010, it was classified as an unregulated medicine in the Netherlands, making the sale and distribution of it illegal.[131][132] The importation of mephedrone into the UK was banned on 29 March 2010.[133] The next day, the ACMD in the UK published a report on the cathinones, including mephedrone, and recommended they be classified as Class B drugs. On 7 April 2010, the Misuse of Drugs Act 1971 (Amendment) Order 2010 was passed by parliament, making mephedrone and other substituted cathinones, Class B drugs from 16 April 2010.[134][135] Prior to the ban taking effect, mephedrone was not covered by the Misuse of Drugs Act 1971.[71] It was, though, an offence under the Medicines Act to sell it for human consumption, so it was often sold as "plant food" or "bath salts", although it has no use as these products; this, too, was possibly illegal under the Trade Descriptions Act 1968.[21][22][9] In the US, similar descriptions have been used to describe mephedrone, as well as methylenedioxypyrovalerone (MDPV).[136] In May 2010, the Republic of Ireland made mephedrone illegal,[137][138][139] followed by Belgium,[140] Italy,[141] Lithuania,[142] France[143][144] and Norway[145] in June and Russia in July.[146] In August 2010, Austria[147] and Poland[148] made it illegal and China announced it would be illegal as of 1 September 2010.[72] Mephedrone had been reported to be used in Singapore in February 2010,[149] but it was made illegal in November 2010.[150] In December 2010, following the advice of the EMCDDA, mephedrone was made illegal throughout the EU, a move Switzerland also made shortly afterwards.[151][152] Countries which have not already banned it, such as the Netherlands, Greece and Portugal, will need to change legislation to comply with the EU ruling.[152] In Hungary, a government advisory body recommended mephedrone should be made illegal in August 2010, which was followed, making it illegal in January 2011;[153][154] Spain followed in February 2011.[155] Mexico, by decree,[156] outlawed mephedrone as a substance "with low or no therapeutical use which pose a serious threat to public health"[157] in 2014.

In some countries, mephedrone is not specifically listed as illegal, but is controlled under legislation that makes compounds illegal if they are analogs of drugs already listed. In Australia during 2010, it was not specifically listed as prohibited,[55] but the Australian Federal Police stated it is an analogue to methcathinone and therefore illegal. It is now listed as a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[158] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[158] In February 2010, 22 men were arrested in connection with importing mephedrone.[159] By January 2011, every state in Australia, other than Victoria, had listed it as a controlled drug.[160]

In New Zealand, it is not included in the Misuse of Drugs Act 1975,[161] but is illegal, as it is similar to controlled substances.[162]

In Canada, mephedrone is not explicitly listed in any schedule of the Controlled Drugs and Substances Act, but "amphetamines, their salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues" are included in Section 19 of Schedule I of the act. Cathinone and methcathinone are listed in separate sections of Schedule III, while diethylpropion and pyrovalerone (also cathinones), are listed in separate sections of Schedule IV, each without language to capture analogues, isomers, etc.[163] Mephedrone is considered a controlled substance by Health Canada.[164] In a report by the Canadian Medical Association in 2010, one lawyer was quoted as suggesting that mephedrone was less popular in Canada than in the U.K. because "there's a provision in the substance act that says analogues of certain drugs and other similar drugs may be illegal too,"; on the other hand, the assistant director of the Centre for Addictions Research of British Columbia suggested there was a lack of "clear illegality".[165] There have been several media reports of the Canadian police seizing mephedrone,[166][167][168] but no reports of any successful prosecution of a Controlled Drugs and Substances Act offence implicating mephedrone.

Mephedrone is also currently scheduled in the United States as of 2011. The Drug Enforcement Administration (DEA) states, as an analogue of methcathinone, possession of mephedrone can be controlled by the Federal Analog Act, but according to the Los Angeles Times, this only applies if it is sold for human consumption.[169][170][171] Several cities and states, such as New York state,[172] have passed legislation to specifically list mephedrone as illegal, but in most areas it remained legal, so long as it is not sold for human consumption, so retailers described it as 'bath salts'.[171] In September 2011, The DEA began using its emergency scheduling authority to temporarily control mephedrone. Except as authorised by law, this action made possessing and selling mephedrone or the products that contain it illegal in the US for at least one year while the DEA and the United States Department of Health and Human Services conduct further study.[173] Control of these compounds became permanent on 9 July 2012, via passage of the Synthetic Drug Abuse Prevention Act of 2012.[174]

Usage edit

A survey conducted in late 2009 by the National Addiction Centre (UK) found 41.3% of readers of Mixmag had used mephedrone in the last month, making it the fourth-most popular drug amongst clubbers. Of those, two-thirds snorted the drug and the average dosage per session was 0.9 g; the length of sessions increased as the dosage increased. Users who snorted the drug reported using more per session than those who took it orally (0.97 g compared to 0.74 g) and also reported using it more often (five days per month compared to three days per month).[12] An Irish study of people on a methadone treatment program for heroin addicts found 29 of 209 patients tested positive for mephedrone usage.[175]

Harm assessment edit

Professor David Nutt, former chair of the Advisory Council on the Misuse of Drugs (ACMD) in the UK has said, "people are better off taking ecstasy or amphetamines than those [drugs] we know nothing about" and "Who knows what's in [mephedrone] when you buy it? We don't have a testing system. It could be very dangerous, we just don't know. These chemicals have never been put into animals, let alone humans."[176] Les King, a former member of the ACMD, has stated mephedrone appears to be less potent than amphetamine and ecstasy, but that any benefit associated with this could be negated by users taking larger amounts. He also told the BBC, "all we can say is [mephedrone] is probably as harmful as ecstasy and amphetamines and wait until we have some better scientific evidence to support that."[52]

See also edit

Notes edit

References edit

  1. ^ Meyer MR, Peters FT, Maurer HH (2009). "Metabolism of the new designer drug mephedrone and toxicological detection of the beta keto designer drugs mephedrone, butylone and methylone in urine" (PDF). Annales de Toxicologie Analytique. 21 (S1): 22.
  2. ^ Anvisa (24 July 2023). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 25 July 2023). from the original on 27 August 2023. Retrieved 27 August 2023.
  3. ^ "Substance Details 4-Methylmethcathinone". Retrieved 22 January 2024.
  4. ^ a b c d e f g h i j k l m n o p . European Monitoring Centre for Drugs and Drug Addiction. 27 May 2010. Archived from the original (PDF) on 26 January 2012. Retrieved 29 January 2011.
  5. ^ a b c d Cumming E (22 April 2010). "Mephedrone: Chemistry lessons". The Daily Telegraph. London. Archived from the original on 12 January 2022. Retrieved 14 September 2010.
  6. ^ "Drugs crackdown hailed a success". BBC News. 8 March 2010. Retrieved 31 March 2010.
  7. ^ Kihara R, Day E (May 2014). "Transient psychotic episodes following recreational use of NRG-3". Progress in Neurology and Psychiatry. 18 (3): 14–18. doi:10.1002/pnp.331. S2CID 70766780.
  8. ^ Schifano F, Albanese A, Fergus S, Stair JL, Deluca P, Corazza O, et al. (April 2011). "Mephedrone (4-methylmethcathinone; 'meow meow'): chemical, pharmacological and clinical issues" (PDF). Psychopharmacology. 214 (3): 593–602. doi:10.1007/s00213-010-2070-x. hdl:2299/16594. PMID 21072502. S2CID 10529974.
  9. ^ a b c . Advisory Council on the Misuse of Drugs. 31 March 2010. p. 25. Archived from the original on 8 December 2010. Retrieved 10 February 2011.
  10. ^ "Mephedrone". Alcohol and Drug Foundation. 10 November 2021. from the original on 18 April 2021. Retrieved 22 November 2021.
  11. ^ a b c d Brunt TM, Poortman A, Niesink RJ, van den Brink W (November 2011). "Instability of the ecstasy market and a new kid on the block: mephedrone". Journal of Psychopharmacology. 25 (11): 1543–7. doi:10.1177/0269881110378370. PMID 20826554. S2CID 7207426.(subscription required)
  12. ^ a b c Winstock AR, Mitcheson LR, Deluca P, Davey Z, Corazza O, Schifano F (January 2011). "Mephedrone, new kid for the chop?". Addiction. 106 (1): 154–61. doi:10.1111/j.1360-0443.2010.03130.x. PMID 20735367.
  13. ^ a b c d e McElrath K, O'Neill C (March 2011). "Experiences with mephedrone pre- and post-legislative controls: perceptions of safety and sources of supply". The International Journal on Drug Policy. 22 (2): 120–7. doi:10.1016/j.drugpo.2010.11.001. PMID 21242082.(subscription required)
  14. ^ a b Matthews AJ, Bruno RB (2010). "Mephedrone use among regular ecstasy consumers in Australia" (PDF). Ecstasy and Related Drug Trends Bulletin. Archived from the original (PDF) on 17 February 2011.
  15. ^ "A joined-up approach to drugs is needed now". Herald Scotland. 21 March 2010. Retrieved 15 September 2010.
  16. ^ a b c Gibbons S, Zloh M (July 2010). "An analysis of the 'legal high' mephedrone". Bioorganic & Medicinal Chemistry Letters. 20 (14): 4135–9. doi:10.1016/j.bmcl.2010.05.065. PMID 20542690.(subscription required)
  17. ^ "Risks of banned drug mephedrone revealed in new research". Science Daily. 15 July 2010. Retrieved 10 February 2011.
  18. ^ Kavanagh PV, McNamara S, Angelov D, McDermott S, Mullan D, Ryder SA (March 2010). "The Characterization of 'Legal Highs' Available from Head Shops in Dublin" (PDF). The Drug Treatment Centre Board. Retrieved 17 February 2011.
  19. ^ Nutt DJ, King LA, Phillips LD (November 2010). "Drug harms in the UK: a multicriteria decision analysis". Lancet. 376 (9752): 1558–1565. CiteSeerX 10.1.1.690.1283. doi:10.1016/S0140-6736(10)61462-6. PMID 21036393. S2CID 5667719.
  20. ^ Winstock AR, Marsden J, Mitcheson L (March 2010). "What should be done about mephedrone?". BMJ. 340: c1605. doi:10.1136/bmj.c1605. PMID 20332508. S2CID 5500659.
  21. ^ a b "Police warning over 'bubble' drug". BBC News. 20 November 2009. Retrieved 27 November 2009.
  22. ^ a b Reed J (13 January 2010). "Clubbers are 'turning to new legal high mephedrone'". BBC News. Retrieved 4 July 2010.
  23. ^ a b James D, Adams RD, Spears R, Cooper G, Lupton DJ, Thompson JP, Thomas SH (August 2011). "Clinical characteristics of mephedrone toxicity reported to the U.K. National Poisons Information Service". Emergency Medicine Journal. 28 (8): 686–9. doi:10.1136/emj.2010.096636. PMC 3143586. PMID 20798084.
  24. ^ Wood DM, Greene SL, Dargan PI (April 2011). "Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone". Emergency Medicine Journal. 28 (4): 280–2. doi:10.1136/emj.2010.092288. PMID 20581379. S2CID 26029573.(subscription required)
  25. ^ Karch SB (January 2015). "Cathinone neurotoxicity (The "3Ms")". Current Neuropharmacology. 13 (1): 21–5. doi:10.2174/1570159X13666141210225009. PMC 4462040. PMID 26074741.
  26. ^ a b Pantano F, Tittarelli R, Mannocchi G, Pacifici R, di Luca A, Busardò FP, Marinelli E (2017). "Neurotoxicity Induced by Mephedrone: An up-to-date Review". Current Neuropharmacology. 15 (5): 738–749. doi:10.2174/1570159X14666161130130718. PMC 5771050. PMID 27908258.
  27. ^ Mead J, Parrott A (May 2020). "Mephedrone and MDMA: A comparative review". Brain Res. 1735: 146740. doi:10.1016/j.brainres.2020.146740. PMID 32087112.
  28. ^ Kamińska K, Noworyta-Sokołowska K, Górska A, Rzemieniec J, Wnuk A, Wojtas A, Kreiner G, Kajta M, Gołembiowska K (October 2018). "The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats". Neurotox Res. 34 (3): 525–537. doi:10.1007/s12640-018-9908-0. PMC 6154178. PMID 29713996.
  29. ^ Wood DM, Davies S, Puchnarewicz M, Button J, Archer R, Ovaska H, et al. (September 2010). "Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity". Journal of Medical Toxicology. 6 (3): 327–30. doi:10.1007/s13181-010-0018-5. PMC 3550484. PMID 20358417.(subscription required)
  30. ^ Garrett G, Sweeney M (September 2010). "The serotonin syndrome as a result of mephedrone toxicity". BMJ Case Reports. 2010: bcr0420102925. doi:10.1136/bcr.04.2010.2925. PMC 3029518. PMID 22778288.(subscription required)
  31. ^ Sammler EM, Foley PL, Lauder GD, Wilson SJ, Goudie AR, O'Riordan JI (August 2010). "A harmless high?". Lancet. 376 (9742): 742. doi:10.1016/S0140-6736(10)60891-4. PMID 20801405. S2CID 205959146.(subscription required)
  32. ^ Nicholson PJ, Quinn MJ, Dodd JD (December 2010). "Headshop heartache: acute mephedrone 'meow' myocarditis". Heart. 96 (24): 2051–2. doi:10.1136/hrt.2010.209338. PMID 21062771. S2CID 36684597.(subscription required)
  33. ^ Ahmed N, Hoy BP, McInerney J (October 2010). "Methaemoglobinaemia due to mephedrone ('snow')". BMJ Case Reports. 2010: bcr0420102879. doi:10.1136/bcr.04.2010.2879. PMC 3027398. PMID 22791577.(subscription required)
  34. ^ a b "Teenager dies of 'net drug' overdose". The Local. 15 December 2008. Retrieved 20 September 2010.
  35. ^ Gustavsson D, Escher C (20 October 2009). [Mephedrone – Internet drug that seems to have come to stay]. Läkartidningen (in Swedish). Archived from the original on 22 October 2009. Retrieved 21 February 2010.
  36. ^ Ghodse H, Corkery J, Ahmed K, Naidoo V, Oyefeso A, Schifano F (July 2010). (PDF). International Centre for Drug Policy, St George's University of London. p. 77. Archived from the original (PDF) on 29 December 2010. Retrieved 2 January 2010.
  37. ^ "Man from Hove died after injecting mephedrone", BBC News website, 27 May 2010; retrieved on 9 June 2012
  38. ^ a b "Teenagers' deaths 'not caused by mephedrone'". BBC News. 28 May 2010. Retrieved 20 September 2010.
  39. ^ Torrance H, Cooper G (October 2010). "The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland". Forensic Science International. 202 (1–3): e62-3. doi:10.1016/j.forsciint.2010.07.014. PMID 20685050.
  40. ^ a b c Fleming N (5 April 2010). "Mephedrone: the anatomy of a media drug scare". The Guardian. London. Retrieved 20 September 2010.
  41. ^ "Scunthorpe community 'awash with methadone'". BBC News. 25 January 2011. Retrieved 10 February 2011.
  42. ^ a b c d Measham F, Moore K, Newcombe R, Welch Z (12 March 2010). "Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition". Drugs and Alcohol Today. 10 (1): 14–21. doi:10.5042/daat.2010.0123. S2CID 56998007.(subscription required)
  43. ^ Dickson AJ, Vorce SP, Levine B, Past MR (April 2010). "Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin". Journal of Analytical Toxicology. 34 (3): 162–8. doi:10.1093/jat/34.3.162. PMID 20406541.(subscription required)
  44. ^ Darke S, Zador D (December 1996). "Fatal heroin 'overdose': a review". Addiction. 91 (12): 1765–72. doi:10.1046/j.1360-0443.1996.911217652.x. PMID 8997759.
  45. ^ Gregg RA, Baumann MH, Partilla JS, Bonano JS, Vouga A, Tallarida CS, et al. (February 2015). "Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats". British Journal of Pharmacology. 172 (3): 883–94. doi:10.1111/bph.12951. PMC 4301696. PMID 25255824.
  46. ^ Ciudad-Roberts A, Camarasa J, Ciudad CJ, Pubill D, Escubedo E (October 2015). "Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition". British Journal of Pharmacology. 172 (20): 4970–84. doi:10.1111/bph.13266. PMC 4621996. PMID 26228024.
  47. ^ Kehr J, Ichinose F, Yoshitake S, Goiny M, Sievertsson T, Nyberg F, Yoshitake T (December 2011). "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats". British Journal of Pharmacology. 164 (8): 1949–58. doi:10.1111/j.1476-5381.2011.01499.x. PMC 3246659. PMID 21615721.
  48. ^ Hadlock GC, Webb KM, McFadden LM, Chu PW, Ellis JD, Allen SC, et al. (November 2011). "4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse". The Journal of Pharmacology and Experimental Therapeutics. 339 (2): 530–6. doi:10.1124/jpet.111.184119. PMC 3200001. PMID 21810934.
  49. ^ a b Meyer MR, Wilhelm J, Peters FT, Maurer HH (June 2010). "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry". Analytical and Bioanalytical Chemistry. 397 (3): 1225–33. doi:10.1007/s00216-010-3636-5. PMID 20333362. S2CID 21471611.(subscription required)
  50. ^ L.J. Marinetti and H.M. Antonides. Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results. J. Anal. Tox. 37: 135–146, 2013.
  51. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 10th edition, Biomedical Publications, Seal Beach, CA, 2014, pp. 1226–1227. ISBN 978-0-9626523-9-4
  52. ^ a b Reed J (13 January 2010). "What is legal high mephedrone?". BBC Newsbeat. Retrieved 20 September 2010.
  53. ^ a b Roussel O, Perrin M, Herard P, Chevance M, Arpino P (2009). "La 4-méthyléphédrone sera-t-elle une "Ecstasy" du XXIème siècle" [Is 4-methylephedrone, an "Ecstasy" of the twenty first century?] (PDF). Annales de Toxicologie Analytique (in French). doi:10.1051/ata/2009048.
  54. ^ Psychonaut WebMapping Research Group (March 2010). (PDF). Institute of Psychiatry, King's College London. Archived from the original (PDF) on 4 July 2011. Retrieved 31 January 2011.
  55. ^ a b c Camilleri A, Johnston MR, Brennan M, Davis S, Caldicott DG (April 2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone". Forensic Science International. 197 (1–3): 59–66. doi:10.1016/j.forsciint.2009.12.048. PMID 20074881.(subscription required)
  56. ^ Toole KE, Fu S, Shimmon RG, Kraymen N (2012). (PDF). Microgram Journal. 9 (1): 27–32. Archived from the original (PDF) on 26 November 2013. Retrieved 29 January 2016.
  57. ^ Saem de Burnaga Sanchez J (1929). "Sur un homologue de l'éphédrine" [On an analogue of ephedrine]. Bulletin de la Société Chimique de France (in French). 45: 284–286.
  58. ^ Morris H (5 April 2010). "Hamilton's Pharmacopeia. Mephedrone: the phantom menace". Vice Magazine. Retrieved 4 July 2010.
  59. ^ a b c Power M (January–February 2010). (PDF). Druglink. Drugscope. pp. 11–13. Archived from the original (PDF) on 21 August 2010. Retrieved 16 September 2010.
  60. ^ Slezak M (10 March 2014). "High as a Kiwi: Inside the nation saying yes to drugs". New Scientist.
  61. ^ Slezak M (11 August 2014). "My recreational drugs can defeat organised crime". New Scientist.
  62. ^ a b c Power M (March–April 2009). (PDF). Druglink. Drugscope. pp. 6–9. Archived from the original (PDF) on 21 August 2010. Retrieved 16 September 2010.
  63. ^ Doward J, Shah O (26 April 2009). "There are many drugs that help people get out of their minds yet stay within the law – they're called 'legal highs'". The Observer. Retrieved 28 October 2010.
  64. ^ Bentur Y, Bloom-Krasik A, Raikhlin-Eisenkraft B (March 2008). "Illicit cathinone ("Hagigat") poisoning". Clinical Toxicology. 46 (3): 206–10. doi:10.1080/15563650701517574. PMID 17852166. S2CID 23603259.(subscription required)
  65. ^ Davies S, Ramsey J, Archer R (November 2009). "Analytical profiles of Methcathinone Related Compounds" (PDF). London Toxicology Group. Retrieved 22 March 2010.
  66. ^ . Psychonaut Web Mapping Project. June–September 2009. Archived from the original on 16 February 2011. Retrieved 19 December 2009.
  67. ^ Guppy D (18 June 2008). "Killer pills hit Cairns". Cairns.com.au. Retrieved 11 August 2009.
  68. ^ . Abc.net.au. 17 June 2008. Archived from the original on 10 February 2010. Retrieved 11 August 2009.
  69. ^ "EMCDDA 2008 Annual Report" (PDF). European Monitoring Centre for Drugs and Drug Addiction. Retrieved 26 November 2009.
  70. ^ "DEA Microgram Bulletin – 4-Methylmethcathinone in Oregon" (PDF). The Drug Enforcement Administration. July 2009. Archived from the original (PDF) on 17 October 2010. Retrieved 29 January 2011.
  71. ^ a b Devlin K (30 April 2009). . The Daily Telegraph. London. Archived from the original on 26 July 2009. Retrieved 16 September 2010.
  72. ^ a b . State Food and Drug Administration, P.R. China. 2 August 2010. Archived from the original on 15 August 2010. Retrieved 12 September 2010.
  73. ^ Gammell C (12 March 2009). . The Daily Telegraph. London. Archived from the original on 12 September 2009. Retrieved 16 September 2010.
  74. ^ Campbell D (17 January 2010). "Fears grow over safety of 'legal high' mephedrone". London: The Observer. Retrieved 19 March 2010.
  75. ^ a b Fleming N (18 March 2010). "Briefing: Should miaow-miaow be banned?". New Scientist. Retrieved 16 September 2010.
  76. ^ "Designer drug abuse out of control: U.N. drugs board; abuse of 4-methyl-methcathinone, or mephedrone". Reuters. 2 March 2011. Retrieved 26 March 2012.
  77. ^ (PDF) (Report). International Narcotics Control Board. March 2011. Archived from the original (PDF) on 2 April 2012. Retrieved 26 March 2012.
  78. ^ Dargan P, Wood D (July 2010). (PDF) (Report). European Monitoring Centre for Drugs and Drug Addiction. Archived from the original (PDF) on 15 July 2011. Retrieved 24 September 2010.
  79. ^ Nutt, David J. (2021). Drugs without the hot air : making sense of legal and illegal drugs (Second ed.). Cambridge. ISBN 9780857844989. Retrieved 27 September 2022.{{cite book}}: CS1 maint: location missing publisher (link)
  80. ^ Extance, Andy. "The rising tide of 'legal highs'". Chemistry World. Retrieved 27 September 2022.
  81. ^ (PDF) (Report). National Treatment Agency for Substance Misuse. October 2010. Archived from the original (PDF) on 1 March 2011. Retrieved 27 October 2010.
  82. ^ a b Fleming N (29 March 2010). "Miaow-miaow on trial: Truth or trumped-up charges?". New Scientist. Retrieved 1 April 2010.
  83. ^ Reed J (20 June 2010). "Newsbeat – Ecstasy 'disappearing' from British clubs". BBC. Retrieved 30 August 2010.
  84. ^ "The Misuse of Drugs Act 1971 (Amendment) Order 2009". UK government. October 2009. Retrieved 31 January 2011.
  85. ^ a b c Silverman J (2010). "Addicted to distortion: the media and UK drugs policy". Safer Communities. 9 (4): 26–31. doi:10.5042/sc.2010.0582.(subscription required)
  86. ^ . Press Association. 4 October 2010. Archived from the original on 15 July 2011. Retrieved 27 October 2010.
  87. ^ Private Eye, "Street of Shame", No. 1259, 2–15 April 2010, p. 6: Way back in January 2009, not long after mephedrone first began to be sold online, members of the web forum attached to the now-defunct "headshop" Champagne Legals discussed what brand name they might attach to the new product, which has the chemical identity dimethylmethcathinone or MM-Cat. "What shall we call this drug? It's called MM-CAT, so why not Miaow?" suggested one. The name did not catch on ... But on 1 November 2009, someone did add the name "Meow" to the Wikipedia entry for Mephedrone at the head of a list of "street names." Three weeks later ... the Sun declared the arrival of a "new party favourite called 'meow meow'" and the world went cat-call crazy. Among a host of recent headlines the Sunday Times has reported on "the rise of Meow", the Times has heralded "Meow Meow arrests", the Sun shrieked about a "Harman snub for Meow Meow Ban" and the Daily Telegraph took a long hard look at the "Meow Meow Menace in Europe." "No one ever called it Meow seriously till the papers picked up on the Wikipedia entry," one drugs expert tells the Eye.
  88. ^ Davey Z, Corazza O, Schifano F, Deluca P (2010). "Mass-information: mephedrone, myths, and the new generation of legal highs". Drugs and Alcohol Today. 10 (3): 24–28. doi:10.5042/daat.2010.0467.(subscription required)
  89. ^ Greenslade R (2 December 2010). "New guide aims to bring sense to the media coverage of drugs". The Guardian. Retrieved 19 December 2010.
  90. ^ a b Anonymous editorial (April 2010). "A collapse in integrity of scientific advice in the UK". Lancet. 375 (9723): 1319. doi:10.1016/S0140-6736(10)60556-9. PMID 20399965. S2CID 39998854.
  91. ^ Silverman J (2010). . British Journalism Review. 21 (4): 31–36. doi:10.1177/0956474810393603. S2CID 143188880. Archived from the original on 12 August 2011.
  92. ^ Dargan PI, Albert S, Wood DM (November 2010). "Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change". QJM. 103 (11): 875–9. doi:10.1093/qjmed/hcq134. PMID 20675396.
  93. ^ "Mephedrone to be made Class B drug 'within weeks'". BBC News. 29 March 2010. Retrieved 31 March 2010.
  94. ^ a b Kmietowicz Z (March 2010). "Home secretary bans mephedrone after taking advice from depleted council". BMJ. 340: c1784. doi:10.1136/bmj.c1784. PMID 20356967. S2CID 8396924.
  95. ^ Taylor P (29 March 2010). "Drug adviser Dr Polly Taylor's full resignation letter". BBC News. Retrieved 15 September 2010.
  96. ^ "Resignation 'threatens drug ban'". BBC News. 29 March 2010. Retrieved 29 March 2010.
  97. ^ "Government adviser Eric Carlin resigns over mephedrone". BBC News. 2 April 2010. Retrieved 2 April 2010.
  98. ^ Rolles S (18 March 2010). . Transform Drug Policy Foundation. Archived from the original on 15 October 2010. Retrieved 13 April 2010.
  99. ^ Doward J (4 April 2010). "Mephedrone row grows as seventh member of drugs panel". London: The Observer. Retrieved 15 September 2010.
  100. ^ Carlin E (2 April 2010). "Eric Carlin's letter of resignation from the ACMD". BBC News. Retrieved 13 April 2010.
  101. ^ Eastwood N (June 2010). "Legal Eye – Mephedrone becomes a class B drug". Drugs and Alcohol Today. 10 (2): 6–9. doi:10.5042/daat.2010.0251.(subscription required)
  102. ^ . The Scunthorpe Telegraph. 27 January 2011. Archived from the original on 8 March 2012. Retrieved 10 February 2011.
  103. ^ Nutt D (April 2011). "Perverse effects of the precautionary principle: how banning mephedrone has unexpected implications for pharmaceutical discovery". Therapeutic Advances in Psychopharmacology. 1 (2): 35–6. doi:10.1177/2045125311406958. PMC 3736901. PMID 23983925.
  104. ^ Mann J (April 2010). "Can we halt the flow of new designer drugs?". Chemistry World. Retrieved 16 September 2010.
  105. ^ Sare J (September–October 2010). (PDF). Druglink. Drugscope. p. 5. Archived from the original (PDF) on 27 September 2011. Retrieved 29 January 2011.
  106. ^ Stratton E (8 December 2010). "Proposals for banning drugs are more draconian than they seem". The Guardian. Retrieved 19 December 2010.
  107. ^ Van Noorden R (6 December 2010). . Nature News. Archived from the original on 28 December 2010. Retrieved 20 December 2010.
  108. ^ . Drugscience.org.uk. Independent Scientific Committee on Drugs. 2010. Archived from the original on 2 July 2012. Retrieved 15 September 2010.
  109. ^ Daly M (September–October 2010). (PDF). Druglink. Drugscope. pp. 6–9. Archived from the original (PDF) on 27 September 2011. Retrieved 29 January 2011.
  110. ^ Winstock A, Mitcheson L, Marsden J (November 2010). "Mephedrone: still available and twice the price". Lancet. 376 (9752): 1537. doi:10.1016/S0140-6736(10)62021-1. PMID 21056754. S2CID 41708575.
  111. ^ "Clubbers 'still using' banned drug mephedrone". BBC News. 8 February 2011. Retrieved 10 February 2011.
  112. ^ Garnett N (9 February 2011). "Mephedrone freely available on the internet despite ban". BBC Radio 5 Live. Retrieved 17 February 2011.
  113. ^ Laurance J (24 November 2010). "Mephedrone ban blamed for rise in cocaine deaths". The Independent. Archived from the original on 12 May 2022. Retrieved 20 December 2010.
  114. ^ Bird S (22 November 2010). "Banned drug may have saved lives, not cost them". Straight Statistics. Retrieved 20 December 2010.
  115. ^ "NRG-1 'legal high' drug is banned". BBC News. 12 July 2010. Retrieved 23 August 2010.
  116. ^ Jones S, Power M (17 August 2010). "Ivory Wave drug implicated in death of 24-year-old man". The Guardian. London. Retrieved 23 August 2010.
  117. ^ Brandt SD, Sumnall HR, Measham F, Cole J (July 2010). "Second generation mephedrone. The confusing case of NRG-1". BMJ. 341: c3564. doi:10.1136/bmj.c3564. PMID 20605894. S2CID 20354123.(subscription required)
  118. ^ Daly M (December 2012). "'Drone Strikes" (PDF). Druglink. Drugscope. pp. 8–11. Retrieved 28 March 2013.
  119. ^ [Swedish Code of Statutes. Regulation amending the Ordinance (1999:58) banning certain hazardous goods] (PDF) (in Swedish). 25 November 2008. Archived from the original (PDF) on 5 July 2011. Retrieved 31 January 2011.
  120. ^ Stigson G (9 June 2010). [15 grams of drugs means two years in prison] (in Swedish). Dala Demokraten. Archived from the original on 19 July 2011. Retrieved 20 September 2010.
  121. ^ (PDF) (Report). 2009. Archived from the original (PDF) on 15 July 2011. Retrieved 14 September 2010.
  122. ^ "Rapujuhlat saaristossa" [Crayfish parties in the archipelago] (in Finnish). City Magazine. September 2009. Retrieved 14 September 2010.
  123. ^ Estonian Ministry of Social Affairs (8 December 2009). [Minister of Social Affairs regulation number 87] (in Estonian). Archived from the original on 20 July 2011. Retrieved 21 September 2010.
  124. ^ "Guernsey mephedrone ban 'only weeks away'". BBC News. 6 April 2010. Retrieved 14 September 2010.
  125. ^ "Guernsey makes Mephedrone class B drug". BBC News. 13 April 2010. Retrieved 14 September 2010.
  126. ^ Campbell A (4 March 2010). "Call to ban legal high mephedrone test change". BBC Newsbeat. Retrieved 17 March 2010.
  127. ^ "Dopuna popisa opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za izradu opojnih droga" [List of narcotic drugs, psychotropic substances and plants from which narcotic drugs and substances that may be used to manufacture drugs can be obtained] (in Croatian). Croatian Ministry of Health and Social Welfare. 28 December 2009. Retrieved 4 July 2010.
  128. ^ "Vierundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" [24th Amendment of narcotics legislation] (in German). Selected laws in Germany – Buzer.de. 22 January 2010. Retrieved 4 July 2010.
  129. ^ Romanian Health Ministry (10 February 2010). "Comunicat de presă Ministerul Sănătăţii a stabilit lista cu plante şi substanţe cu proprietăţi psihoactive care vor fi interzise, după ce s-au dovedit a fi periculoase pentru sănătate" [Press release: The Health Ministry has established a list of plants and other substances with psychoactive properties that will be banned, after it has been proven that they are dangerous to health] (in Romanian). Romanian Health Ministry. Archived from the original on 10 February 2011. Retrieved 21 September 2010.
  130. ^ . Isle of Man Today. 25 February 2010. Archived from the original on 28 February 2010. Retrieved 4 July 2010.
  131. ^ "Club drug mephedrone faces ban in U.K." CBC News. 29 March 2010. Retrieved 18 March 2014.
  132. ^ . Drugtext.org. Archived from the original on 10 December 2014. Retrieved 18 March 2014.
  133. ^ Ilston G (1 April 2010). . Police Professional. Archived from the original on 15 July 2011. Retrieved 21 September 2010.
  134. ^ "BBC – Democracy Live – MPs move to ban mephedrone". BBC News. 7 April 2010. Retrieved 8 April 2010.
  135. ^ . Office of Public Sector Information. 16 April 2010. Archived from the original on 5 January 2011. Retrieved 8 April 2010.
  136. ^ Victoria Cumbow (6 February 2011). "Synthetic form of cocaine and methamphetamine being packaged as bath salts". The Huntsville Times. Retrieved 10 February 2011.
  137. ^ Kelly F (3 March 2010). "Head shop substances to be banned". Irish Independent. Retrieved 21 September 2010.
  138. ^ . Irish Department of Health and Children. 11 May 2010. Archived from the original on 21 February 2011. Retrieved 22 August 2010.
  139. ^ Gartland F (6 November 2009). . The Irish Times. Archived from the original on 23 October 2010. Retrieved 21 September 2010.
  140. ^ "Arrêté royal du 13 Juin 2010 portant modification de l'arrêté royal du 22 janvier 1998 réglementant certaines substances psychotropes, et relatif à la réduction des risques et à l'avis thérapeutique" [Royal Decree of 13 June 2010 amending the Royal Decree of 22 January 1998 regulating certain psychotropic substances, therapeutic advice and on reducing risk] (in French). Belgian Department of Justice. 13 June 2010. Retrieved 5 July 2010.
  141. ^ [Table of drugs and psychotropics] (in Italian). Italian Ministry of Health. 10 June 2010. Archived from the original on 27 June 2011. Retrieved 2 January 2011.
  142. ^ Ministry of Health of the Republic of Lithuania (18 June 2010). [6 January 2000 Order no. 5 of narcotic drugs and psychotropic substances list] (in Lithuanian). Archived from the original on 30 November 2020. Retrieved 21 September 2010.
  143. ^ AFP (11 June 2010). [Classification of mephedrone from khat as a narcotic] (in French). france24.com. Archived from the original on 16 June 2010. Retrieved 4 July 2010.
  144. ^ [Mephedrone classified as a narcotic] (in French). French Ministry of Health and Sports. 11 June 2010. Archived from the original on 20 October 2010. Retrieved 26 October 2010.
  145. ^ [Ten new compounds for drug list] (in Norwegian). Norwegian Broadcasting Corporation (NRK). 11 June 2010. Archived from the original on 14 June 2010. Retrieved 31 August 2010.
  146. ^ Government of the Russian Federation (29 July 2010). [Decree of 29 July 2010 number 578] (in Russian). Archived from the original on 24 July 2011. Retrieved 19 November 2010.
  147. ^ [Fashionable drug mephedrone illegal in Austria] (in German). Die Presse. 22 August 2010. Archived from the original on 11 October 2012. Retrieved 22 August 2010.
  148. ^ "Ustawa z dnia 10 czerwca 2010 r. o zmianie ustawy o przeciwdziałaniu narkomanii" [The Law of 10 June 2010 amending the Act on Counteracting Drug Addiction] (in Polish). Polish Internet Database System of Legal Acts. 10 June 2010. Retrieved 25 August 2010.
  149. ^ Loh L (24 February 2010). "Legal in Singapore – the party drug that's banned everywhere else". Cnngo.com. Retrieved 4 July 2010.
  150. ^ Yeo A (13 November 2010). . Todayonline. Archived from the original on 28 January 2011. Retrieved 16 November 2010.
  151. ^ Hermsmeier K (28 August 2010). [I fell into the party drug "Meow"]. Archived from the original on 19 July 2011. Retrieved 21 September 2010.
  152. ^ a b Impey J (3 December 2010). . Deutsche Welle. Archived from the original on 9 February 2011. Retrieved 19 December 2010.
  153. ^ "Eldőlt: betiltják a katit" [Decided: cathinones banned] (in Hungarian). 2 September 2010. Retrieved 2 January 2011.
  154. ^ "Magyar közlöny 2010. december 15. Kormányrendelet a Mephedrone listáravételéről" [Hungarian Government bans Mephedrone] (PDF) (in Hungarian). 15 December 2010. Retrieved 24 January 2011.
  155. ^ "Documento BOE-A-2011-2490". BOE.es. pp. 13595–13596. Retrieved 18 March 2014.
  156. ^ "DECRETO por el que se reforman las fracciones I y III del artículo 245 de la Ley General de Salud". Diario Oficial de la Federación (in Spanish). Secretaría de Gobernación. 7 January 2014. Retrieved 1 September 2014.
  157. ^ "Mexico: mephedrone, TFMPP and synthetic cannabinoids placed under control". United Nations Office on Drugs and Crime. United Nations. January 2014. Retrieved 1 September 2014.
  158. ^ a b Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
  159. ^ . Sydney Morning Herald. 12 February 2010. Archived from the original on 1 August 2010. Retrieved 21 September 2010.
  160. ^ Levy M (22 January 2011). "Judge puts users of new drug on notice". The Age. Retrieved 17 February 2011.
  161. ^ . New Zealand Ministry of Health. 1 December 2009. Archived from the original on 19 May 2011. Retrieved 4 July 2010.
  162. ^ Edens J (14 September 2010). . The Southland Times. Archived from the original on 16 September 2010. Retrieved 21 September 2010.
  163. ^ . Canadian Department of Justice. 20 June 1996. Archived from the original on 6 January 2011. Retrieved 29 January 2011.
  164. ^ Chan K (18 March 2010). . Globe and Mail. Archived from the original on 29 June 2010. Retrieved 23 March 2010.
  165. ^ Elwell A (June 2010). "Britain moves to curtail new drug craze" (PDF). CMAJ. 182 (9): E393-4. doi:10.1503/cmaj.109-3245. PMC 2882479. PMID 20421358.
  166. ^ "U.K. party drug hits St. John's streets". CBC News. 25 June 2010. Retrieved 22 August 2010.
  167. ^ McCallum J (18 August 2010). . The Montreal Gazette. Archived from the original on 22 August 2010. Retrieved 22 August 2010.
  168. ^ "RNC seizes designer drug". The Telegram. 25 June 2010. Retrieved 22 August 2010.
  169. ^ . Justice.gov. Archived from the original on 7 February 2011. Retrieved 4 July 2010.
  170. ^ . United States Drug Enforcement Administration. July 2010. Archived from the original on 13 December 2010. Retrieved 21 September 2010.
  171. ^ a b Sewell A (28 January 2011). . Los Angeles Times. Archived from the original on 16 February 2011. Retrieved 17 February 2011.
  172. ^ "New York State Health Commissioner Bans Sale and Distribution of Dangerous Substances Marketed as Bath Salts". New York State Health Department. 23 May 2011. Retrieved 22 June 2011.
  173. ^ Ferran L. (7 September 2011). "DEA Announces Emergency Ban on 'Bath Salts'". ABC News. Retrieved 8 September 2011.
  174. ^ Keim B (12 July 2012). "New Federal Ban on Synthetic Drugs Already Obsolete". Wired. Retrieved 18 March 2014.
  175. ^ McNamara S, Stokes S, Coleman N (May 2010). . Irish Medical Journal. 103 (5): 134, 136–7. PMID 20666082. Archived from the original on 21 July 2011.
  176. ^ Saner E (5 December 2009). "Mephedrone and the problem with 'legal highs'". The Guardian. London. Retrieved 20 September 2010.

External links edit

  • European Monitoring Center for Drugs and Drug Addiction (2011). Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances (Report). Publications Office. doi:10.2810/40800.
  • Erowid 4-Methylmethcathinone Vault
  • www.lifeline.org.uk
  • Guardian Daily Podcast: How dangerous is mephedrone?
  • ChemSub Online: Mephedrone

January 01, 1970
mephedrone, confused, with, methedrine, methedrone, mephedrene, methadone, methylone, methcathinone, ephedrone, also, known, methylmethcathinone, methylephedrone, synthetic, stimulant, drug, amphetamine, cathinone, classes, slang, names, include, drone, white,. Not to be confused with methedrine methedrone mephedrene methadone methylone methcathinone or ephedrone Mephedrone also known as 4 methylmethcathinone 4 MMC and 4 methylephedrone is a synthetic stimulant drug of the amphetamine and cathinone classes Slang names include drone 5 M CAT 6 White Magic 7 meow meow and bubble 8 It is chemically similar to the cathinone compounds found in the Khat plant of eastern Africa 5 9 It comes in the form of tablets or crystals 10 which users can swallow snort or inject producing effects similar to those of MDMA amphetamines and cocaine MephedroneClinical dataOther names4 methyl N methylcathinone 2 methylamino 1 p tolylpropan 1 one 1 Routes ofadministrationOral insufflation IV rectalATC codenoneLegal statusLegal statusAU S8 Controlled drug BR Class F2 Prohibited psychotropics 2 DE Anlage I Authorized scientific use only UK Class B US Schedule I UN Psychotropic Schedule II 3 IdentifiersIUPAC name RS 2 Methylamino 1 4 methylphenyl propan 1 one 4 5 CAS Number1189805 46 6 N 1189726 22 4 HCl 4 5 PubChem CID29982893ChemSpider21485694 YUNII8BA8T27317KEGGC22785ChEBICHEBI 59331 YCompTox Dashboard EPA DTXSID20891437ECHA InfoCard100 189 720Chemical and physical dataFormulaC 11H 15N OMolar mass177 247 g mol 13D model JSmol Interactive imageSMILES CC1 CC C C C NC C O C C1InChI InChI 1S C11H15NO c1 8 4 6 10 7 5 8 11 13 9 2 12 3 h4 7 9 12H 1 3H3 YKey YELGFTGWJGBAQU UHFFFAOYSA N Y N Y what is this verify In addition to its stimulant effects mephedrone produces side effects of which bruxism is the most common The metabolism of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage Mephedrone was first synthesised in 1929 but did not become widely known until it was rediscovered in 1999 2000 at which point it was legal to produce and possess in many countries By 2000 mephedrone was reported to be available for sale on the internet by 2008 law enforcement agencies had become aware of the compound and by 2010 it had been reported in most of Europe becoming particularly prevalent in the United Kingdom Mephedrone was first made illegal in Israel in 2008 followed by Sweden later that year In 2010 it was made illegal in many European countries and in December 2010 the EU ruled it illegal In Australia New Zealand and the United States it is considered an analog of other illegal drugs and can be controlled by laws similar to the US Federal Analog Act In September 2011 the US temporarily classified mephedrone as a Schedule I drug effective October 2011 This classification was made permanent in July 2012 with the passage of the Synthetic Drug Abuse Prevention Act SDAPA Contents 1 Uses 1 1 Recreational 1 2 Available forms 1 2 1 Purity 2 Adverse effects 2 1 Short term effects 2 2 Neurotoxicity 2 3 Reinforcement disorders 3 Overdose 3 1 Toxicity 3 2 Deaths 3 2 1 Sweden 3 2 2 United Kingdom 3 2 3 United States 4 Pharmacology 4 1 Pharmacodynamics 4 2 Pharmacokinetics 4 2 1 Metabolism 4 3 Detection in body fluids 5 Chemistry 5 1 Appearance and odour 5 2 Synthesis 5 3 Analysis 6 History 6 1 United Kingdom 7 Society and culture 7 1 Legal status 7 2 Usage 7 3 Harm assessment 8 See also 9 Notes 10 References 11 External linksUses editRecreational edit Users have reported that mephedrone causes euphoria stimulation an enhanced appreciation for music an elevated mood decreased hostility improved mental function and mild sexual stimulation these effects are similar to the effects of cocaine amphetamines and MDMA and last different lengths of time depending on the way the drug is taken Of 70 Dutch users of mephedrone 58 described it as an overall pleasant experience and 12 described it as an unpleasant experience 11 In a survey of UK users who had previously taken cocaine most users found it produced a better quality and longer lasting high and was less addictive The users were also asked to compare the risk and they answered that it was equal 12 A study of users in Northern Ireland found they did not equate the fact that mephedrone was legal with it being safe to use This was contrary to another study in New Zealand where users of benzylpiperazine thought that because it was legal it was safe 13 Available forms edit Mephedrone can come in the form of capsules tablets or white powder that users may swallow snort inject smoke or use rectally 4 12 12 14 When taken orally users reported they could feel the effects within 15 45 minutes when snorted the effects were felt within minutes and peaked within half an hour The effects last for between two and three hours when taken orally or nasally but only half an hour if taken intravenously 4 12 It is sometimes sold mixed with methylone in a product called bubbles in the UK 15 and also mixed with other cathinones including ethcathinone butylone fluoromethcathinone and methedrone 4 9 Purity edit One published study that analysed samples of mephedrone bought using the internet in the UK in 2010 found it was racemic a mixture of both stereoisomers and of high purity 16 An unpublished study of six samples also ordered off the internet in the UK in 2010 found they contained very few organic impurities 17 Four products sold in Irish head shops were tested in 2010 and were found to contain between 82 and 14 mephedrone with some products containing benzocaine and caffeine 18 Adverse effects edit nbsp Table from the 2010 ISCD study ranking various drugs legal and illegal based on statements by drug harm experts Mephedrone was found to be the 13th overall most dangerous drug 19 Short term effects edit The EMCDDA reported mephedrone can cause various unintended side effects including dilated pupils 20 poor concentration teeth grinding problems focusing visually poor short term memory hallucinations delusions and erratic behaviour 4 13 They noted the most severe effects appear anecdotally to be linked with high doses or prolonged use and the effects may be due to users taking other intoxicants at the same time Other effects users in internet forums have noted include changes in body temperature increased heart rate breathing difficulties loss of appetite increased sweating discolouration of extremities anxiety paranoia and depression 4 13 When snorted it can also cause nose bleeds and nose burns 4 13 21 A survey conducted by the UK National Addiction Centre found 67 of mephedrone users experienced sweating 51 suffered from headaches 43 from heart palpitations 27 from nausea and 15 from cold or blue fingers 22 indicative of vasoconstriction occurring 23 Doctors at Guy s Hospital in London reported that of 15 patients they treated after taking mephedrone in 2009 53 were agitated 40 had increased heart rates 20 had systolic hypertension and 20 had seizures three required treatment with benzodiazepines predominantly to control their agitation They reported none of their patients suffered from cold or blue peripheries contrary to other reports Nine of the 15 of patients had a Glasgow coma scale GCS of 15 indicating they were in a normal mental state four had a GCS below 8 but these patients all reported using a central nervous system depressant most commonly GHB with mephedrone The patients also reported polydrug use of a variety of compounds 24 Neurotoxicity edit Mephedrone is neurotoxic and induces injury to the 5 HT neurons 25 26 27 Although some studies in animal models reported no damage to DA nerve endings in the striatum and no significant changes in brain monoamine levels some others suggested a rapid reduction in 5 HT and DA transporter function Persistent serotonergic deficits were observed after binge like treatment in a warm environment and in both serotonergic and dopaminergic nerve endings at high ambient temperature Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported 26 28 Reinforcement disorders edit There have been reports of users craving mephedrone suggesting it may be addictive 4 13 11 Overdose editToxicity edit In 2009 one case of sympathomimetic toxicity was reported in the UK after a person took 0 2 g of mephedrone orally and after this did not achieve the desired effect intramuscularly injected 3 8 g mixed with water into his thighs Shortly afterwards the user developed palpitations blurred tunnel vision chest pressure and sweating The patient was treated with 1 mg of lorazepam and the sympathomimetic features decreased and the user was discharged within six hours of arrival 29 One case of serotonin syndrome has been reported where the patient was already prescribed fluoxetine and olanzapine and then took 40 tablets containing mephedrone in one night He was treated with lorazepam and discharged 15 hours after admission 30 Both enantiomers of methcathinone which differs only in the lack of the methyl group on the aryl ring when compared to mephedrone have been shown to be toxic to rat dopamine neurons and the S enantiomer was also toxic against serotonin neurons Simon Gibbons and Mire Zloh of the School of Pharmacy University of London stated based on the chemical similarities between methcathinone and mephedrone it is highly likely that mephedrone will display neurotoxicity 16 However Brunt and colleagues stated extreme caution should be used when inferring the toxicity of mephedrone from methcathinone noting some of the toxicity associated with methcathinone is due to manganese impurities related to its synthesis rather than the compound itself They concluded more experimental research is needed to investigate the toxicity of mephedrone 11 Doctors who treated a 15 year old female suffering from mephedrone intoxication suggested in The Lancet that like MDMA mephedrone may promote serotonin mediated release of antidiuretic hormone resulting in hyponatraemia and an altered mental state 31 In another case a 19 year old male was admitted to hospital suffering from inflammation of the heart 20 hours after taking one gram of mephedrone The doctors treating the patient stated it was caused by either a direct toxic effect of mephedrone on the heart muscle or by an immune response 32 One case of acquired methaemoglobinaemia where a patient had bluish lips and fingers has also been reported after the user snorted one gram of mephedrone The patient started to recover after arriving at the hospital and it was not necessary to administer any medication 33 Deaths edit Sweden edit In 2008 an 18 year old Swedish woman died in Stockholm after taking mephedrone The newspaper Svenska Dagbladet reported the woman went into convulsions and turned blue in the face 34 Doctors reported she was comatose and suffering from hyponatremia and severe hypokalemia the woman died one and a half days after the onset of symptoms An autopsy showed severe brain swelling 35 Mephedrone was scheduled to be classified as a dangerous substance in Sweden even before the woman s death at Karolinska University Hospital on 14 December but the death brought more media attention to the drug The possession of mephedrone became classified as a criminal offence in Sweden on 15 December 2008 34 United Kingdom edit In 2010 unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK By July 2010 mephedrone had been alleged to be involved in 52 fatalities in the UK but detected in only 38 of these cases Of the nine that coroners had finished investigating two were caused directly by mephedrone 36 The first death reported to be caused by mephedrone use was that of 46 year old John Sterling Smith 37 who had underlying health problems and repeatedly injected the drug 38 A report in Forensic Science International in August 2010 stated mephedrone intoxication has been recorded as the cause of death in two cases in Scotland Post mortem samples showed the concentration of mephedrone in their blood was 22 mg L in one case and 3 3 mg L in the other 39 The death of a teenager in the UK in November 2009 was widely reported as being caused by mephedrone but a report by the coroner concluded she had died from natural causes 40 In March 2010 the deaths of two teenagers in Scunthorpe were widely reported by the media to be caused by mephedrone Toxicology reports showed the teenagers had not taken any mephedrone and had died as a result of consuming alcohol and the synthetic opioid agonist methadone 38 41 According to Fiona Measham a criminologist who is a member of the ACMD the reporting of the unconfirmed deaths by newspapers followed the usual cycle of exaggeration distortion inaccuracy and sensationalism associated with the reporting of recreational drug use 42 United States edit Mephedrone has been implicated in the death of a 22 year old man who had also injected black tar heroin Mephedrone was found in his blood at a concentration of 0 50 mg L and in his urine at a concentration of 198 mg L The blood concentration of morphine a metabolite of heroin was 0 06 mg L 43 For comparison the average blood morphine concentration resulting from deadly overdoses involving only heroin is around 0 34 mg L 44 Pharmacology editThis section needs to be updated Please help update this article to reflect recent events or newly available information March 2015 Pharmacodynamics edit Mephedrone is a monoamine releasing agent It is a chiral compound and both of its enantiomers display similar potency as substrates at dopamine transporters R Mephedrone is much less potent than S mephedrone as a substrate at serotonin transporters 45 The keto oxygen renders mephedrone more hydrophilic than the corresponding amphetamine 4 Methylmethamphetamine which may account for the higher doses required to achieve a similar effect because mephedrone is less able to cross the blood brain barrier 4 12 16 Mephedrone is often consumed with alcohol A study in mice investigated the interrelation between these two substances focusing on the psychostimulant and rewarding properties of mephedrone It found that at low non stimulant doses alcohol significantly enhanced the psychostimulant effects of mephedrone This effect was mediated by an increase in synaptic dopamine as haloperidol but not ketanserin was able to block the potentiation by alcohol Similarly the rewarding properties of mephedrone were enhanced by a low non rewarding dose of alcohol 46 Pharmacokinetics edit Several articles published near the end of 2011 examined the effects of mephedrone compared to the similar drugs MDMA and amphetamine in the nucleus accumbens of rats as well as examining the reinforcing potential of mephedrone Dopamine and serotonin were collected using microdialysis and increases in dopamine and serotonin were measured using HPLC Reward and drug seeking are linked to increases in dopamine concentrations in the nucleus accumbens and drug half life plays a role in drug seeking as well Based on histological examination most of the author s probes were in the nucleus accumbens shell Mephedrone administration caused about a 500 increase in dopamine and about a 950 increase in serotonin They reached their peak concentrations at 40 minutes and 20 minutes respectively and returned to baseline by 120 minutes after injection In comparison MDMA caused a roughly 900 increase in serotonin at 40 minutes with an insignificant increase in dopamine Amphetamine administration resulted in about a 400 increase in dopamine peaking at 40 minutes with an insignificant increase in serotonin Analysis of the ratio of the AUC for dopamine DA and serotonin 5 HT indicated mephedrone was preferentially a serotonin releaser with a ratio of 1 22 1 serotonin vs dopamine Additionally half lives for the decrease in DA and 5 HT were calculated for each drug Mephedrone had decay rates of 24 5 minutes and 25 5 minutes respectively MDMA had decay values of 302 5 minutes and 47 9 minutes respectively while amphetamine values were 51 minutes and 84 1 minutes respectively Taken together these findings show mephedrone induces a massive increase in both DA and 5 HT combined with rapid clearance The rapid rise and subsequent fall of DA levels could explain some of the addictive properties mephedrone displays in some users 47 48 Metabolism edit Based on the analysis of rat and human urine by gas chromatography and mass spectrometry mephedrone is thought to be metabolised by three phase 1 pathways It can be demethylated to the primary amine producing compounds 2 3 and 5 the ketone group can be reduced producing 3 or the tolyl group can be oxidised producing 6 Both 5 and 6 are thought to be further metabolised by conjugation to the glucuronide and sulfate derivatives Knowledge of the primary routes of metabolism should allow the intake of mephedrone to be confirmed by drug tests as well as more accurate determination of the causes of side effects and potential for toxicity 49 nbsp Proposed scheme for the metabolism of mephedrone 1 based on the analysis of rat and human urine 49 Detection in body fluids edit Mephedrone may be quantitated in blood plasma or urine by gas chromatography mass spectrometry or liquid chromatography mass spectrometry to confirm a diagnosis of poisoning in hospitalised patients or to provide evidence in a medicolegal death investigation Blood or plasma mephedrone concentrations are expected to be in a range of 50 100 mg L in persons using the drug recreationally gt 100 mg L in intoxicated patients and gt 500 mg L in victims of acute overdosage 50 51 Chemistry editAppearance and odour edit Mephedrone is a white substance It is sold most commonly as crystals or a powder but also in the form of capsules or pills 52 53 It can have a distinctive odour reported to range the smell of vanilla and bleach stale urine or electric circuit boards 54 Synthesis byproducts or other contaminants are likely responsible for this as the molecule itself is not an odorant Synthesis edit Mephedrone can be synthesised in several ways The simplest method due to the availability of the compounds 4 17 is to add 4 methylpropiophenone dissolved in glacial acetic acid to bromine creating an oil fraction of 4 methyl 2 bromopropiophenone The oil fraction can then be dissolved in dichloromethane CH2Cl2 and drops of the solution added to another solution of CH2Cl2 containing methylamine hydrochloride and triethylamine Hydrochloric acid HCl is then added and the aqueous layer is removed and turned alkaline using sodium hydroxide before the amine is extracted using CH2Cl2 The CH2Cl2 is then evaporated using a vacuum creating an oil which is then dissolved in a nonaqueous ether Finally HCl gas is bubbled through the mixture to produce 4 methylmethcathinone hydrochloride 55 This method produces a mixture of both enantiomers and requires similar knowledge to that required to synthesise amphetamines and MDMA 4 17 nbsp Mephedrone synthesis scheme from 4 methylpropiophenone It can also be produced by oxidising the ephedrine analogue 4 methylephedrine using potassium permanganate dissolved in sulfuric acid Because 4 methylephedrine can be obtained in a specific enantiomeric form mephedrone consisting of only one enantiomer can be produced The danger associated with this method is it may cause manganese poisoning if the product is not correctly purified 4 17 Analysis edit Mephedrone does not react with most reagent testing kits The exception is the Liebermann reagent which gives a bright yellow reaction 56 History edit nbsp Mephedrone Not for human consumption For technical use only Purity 99 Mephedrone is one of hundreds of designer drugs or legal highs that have been reported in recent years including artificial chemicals such as synthetic cannabis and semisynthetic substances such as methylhexanamine These drugs are primarily developed to avoid being controlled by laws against illegal drugs thus giving them the label of designer drugs 13 According to the European Monitoring Centre for Drugs and Drug Addiction the synthesis of mephedrone was first reported in 1929 by Saem de Burnaga Sanchez in the Bulletin de la Societe Chimique de France under the name toluyl alpha monomethylaminoethylcetone 4 17 57 but the compound remained an obscure product of academia until 2003 when it was re discovered and publicised by an underground chemist on The Hive website registered to a Portuguese IP working under the pseudonym Kinetic 58 Kinetic posted on the site I ve been bored over the last couple of days and had a few fun reagents lying around so I thought I d try and make some 1 4 methylphenyl 2 methylaminopropanone hydrochloride or 4 methylmethcathinone before going on to describe that after consuming it the user had a fantastic sense of well being that I haven t got from any drug before except my beloved Ecstasy 59 After the initial description of mephedrone s qualitative effects by Kinetic the drug was commercially introduced in Israel by a mathematician named Ezekiel Golan or Dr Z 60 61 A drug similar to mephedrone containing cathinone was sold legally in Israel from around 2004 under the name hagigat When this was made illegal the cathinone was modified and the new products were sold by the Israeli company Neorganics 62 63 64 The products had names such as Neodoves pills but the range was discontinued in January 2008 after the Israeli government made mephedrone illegal 5 55 65 The Psychonaut Research Project an EU organisation that searches the internet for information regarding new drugs first identified mephedrone in 2008 Their research suggested the drug first became available to purchase on the internet in 2007 made available through British contacts contact unknown when it was also discussed on internet forums 13 66 Mephedrone was first seized in France in May 2007 after police sent a tablet they assumed to be ecstasy to be analysed with the discovery published in a paper titled Is 4 methylephedrone an Ecstasy of the twenty first century 53 Mephedrone was reported as having been sold as ecstasy in the Australian city of Cairns along with ethylcathinone in 2008 67 68 An annual survey of regular ecstasy users in Australia in 2010 found 21 of those surveyed had used mephedrone with 17 having done so in the previous six months The price they paid per gram varied from A 16 to 320 14 Europol noted they became aware of it in 2008 after it was found in Denmark Finland and the UK 69 The Drug Enforcement Administration noted it was present in the United States in July 2009 70 By May 2010 mephedrone had been detected in all 22 EU member states that reported to Europol as well as in Croatia and Norway 4 21 The Daily Telegraph reported in April 2009 that it was manufactured in China but it has since been made illegal there 71 72 In March 2009 Druglink magazine reported it only cost a couple of hundred pounds to synthesise a kilogram of mephedrone 62 the same month The Daily Telegraph reported manufacturers were making huge amounts of money from selling it 73 In January 2010 Druglink magazine reported dealers in Britain spent 2 500 to ship one kilogram from China but could sell it for 10 a gram making a profit of 7 500 59 74 A later report in March 2010 stated the wholesale price of mephedrone was 4000 per kilogram 75 In March 2011 the International Narcotics Control Board published a report about designer drugs noting mephedrone was by then being used recreationally in Europe North America Southeast Asia New Zealand and Australia 76 77 United Kingdom edit nbsp The number of samples analysed by the Forensic Science Service of seized MDMA piperazines and cathinones between the third quarter of 2005 and the first quarter of 2010 MDMA seizures in blue piperazine seizures in orange and cathinone seizures in purple 78 Between the summer of 2009 and March 2010 the use of mephedrone grew rapidly in the UK with it becoming readily available at music festivals head shops and on the internet 42 A survey of Mixmag readers in 2009 found it was the fourth most popular street drug in the United Kingdom behind cannabis cocaine and ecstasy 75 The drug was used by a diverse range of social groups Whilst the evidence was anecdotal researchers charity workers teachers and users reported widespread and increasing use of the drug in 2009 The drug s rapid growth in popularity was believed to be related to both its availability and legality 42 In a book about drugs 79 David Nutt reports the re popularization story of mephedrone in a way that can be cross referenced with a report by Chemistry World in an article 80 Fiona Measham a criminologist at The University of Lancaster thought the emergence of mephedrone was also related to the decreasing purity of ecstasy and cocaine on sale in the UK 42 a view reinforced in a report by the National Treatment Agency for Substance Misuse 81 The average cocaine purity fell from 60 in 1999 to 22 in 2009 and about half of ecstasy pills seized in 2009 contained no MDMA 82 and by June 2010 almost all ecstasy pills seized in the UK contained no MDMA 83 A similar pattern was observed in the Netherlands with the number of ecstasy tablets containing no MDMA rising from 10 in mid 2008 to 60 by mid 2009 with mephedrone being detected in 20 of ecstasy tablets by mid 2009 11 The decrease of MDMA was thought to be partly due to the seizure of 33 tonnes of sassafras oil the precursor to MDMA in Cambodia in June 2008 which could have been used to make 245 million doses of MDMA 59 According to John Ramsey a toxicologist at St George s University of London the emergence of mephedrone was also related to the UK government banning the benzylpiperazine class of drugs in December 2009 62 84 gamma Butyrolactone GBL another previously legal high was also banned in August 2009 despite concerns it would be replaced by other drugs 85 By December 2009 mephedrone was available on at least 31 websites based in the UK and by March 2010 there were at least 78 online shops half of which sold amounts of less than 200 grams and half that also sold bulk quantities The price per gram varied from 9 50 to 14 4 11 Between July 2009 and February 2010 UK health professionals accessed the National Poisons Information Service s NPIS entry on mephedrone 1664 times and made 157 telephone inquiries the requests increased month on month over this period In comparison over a similar time period the entries for cocaine and MDMA were accessed approximately 2400 times 23 After mephedrone was made illegal the number of inquiries to the NPIS fell substantially to only 19 in June 2010 86 Media organisations including the BBC and The Guardian incorrectly reported mephedrone was commonly used as a plant fertiliser In fact sellers of the drug described it as plant food because it was illegal to sell the compound for human consumption 82 In late 2009 UK newspapers began referring to the drug as meow or miaow sometimes doubled as meow meow or miaow miaow a name that was almost unknown on the street at the time 87 In November 2009 the tabloid newspaper The Sun published a story stating that a man had ripped off his own scrotum whilst using mephedrone The story was later shown to be an online joke posted on mephedrone com later included in a police report with the caveat that it could be unreliable The police report was used as a source for the story in The Sun 40 88 Other myths the media often repeated during 2010 were that mephedrone had led to the deaths of over 20 people teachers were unable to confiscate the drug from pupils and the government was too slow to ban the drug 89 Parallels were drawn between the media coverage of mephedrone and a piece of satire by Chris Morris in 1997 on Brass Eye when he tricked public figures into talking of the dangers of taking the fictional legal drug cake 40 The Advisory Council on the Misuse of Drugs ACMD have suggested that the media coverage of the drug led to its increased usage 90 Jon Silverman a former BBC Home Affairs Correspondent has written two articles discussing how the media had a strong influence over the UK government s drugs policy particularly in that the government wished to demonstrate they were being tough on drugs 85 91 A survey of 1000 secondary school pupils and university students in Tayside conducted in February 2010 found 20 of them had previously taken mephedrone Although at the time it was available legally over the internet only 10 of users reported purchasing it online with most purchasing it from street dealers Of those who had used mephedrone 97 said it was easy or very easy to obtain Around 50 of users reported at least one negative effect associated with the use of mephedrone of which teeth grinding is the most common 92 Detailed interviews with users in Northern Ireland similarly found that few purchased mephedrone online with most interviewees citing concerns that their address would be traced or that family members could intercept the package 13 On 30 March 2010 Alan Johnson the then Home Secretary announced mephedrone would be made illegal within weeks after the ACMD sent him a report on the use of cathinones 9 93 The legislation would make all cathinones illegal which Johnson said would stop unscrupulous manufacturers and others peddling different but similarly harmful drugs 94 The ACMD had run into problems with the UK Government in 2009 regarding drugs policy after the government did not follow the advice of the ACMD to reclassify ecstasy and cannabis culminating in the dismissal of the ACMD chairman David Nutt after he reiterated the ACMD s findings in an academic lecture 95 Several members resigned after he was sacked and prior to the announcement that mephedrone was to be banned the trend continued when Dr Polly Taylor resigned saying she did not have trust in the way the government would use the advice given by the ACMD 96 Eric Carlin a member of the ACMD and former chairman of the English Drug Education Forum also resigned after the announcement He said the decision by the Home Secretary was unduly based on media and political pressure and there was little or no discussion about how our recommendation to classify this drug would be likely to impact on young people s behaviour 97 Some former members of the ACMD and various charity groups expressed concern over the banning of the drug arguing it would inevitably criminalise users particularly young people 98 Others expressed concern that the drug would be left in the hands of black market dealers who will only compound the problem 99 Carlin s resignation was specifically linked to the criminalisation of mephedrone he stated We need to review our entire approach to drugs dumping the idea that legally sanctioned punishments for drug users should constitute a main part of the armoury in helping to solve our country s drug problems We need to stop harming people who need help and support 100 The parliamentary debate was held on 8 April one day after the 2010 general election had been announced meaning it was during the so called wash up period when legislation is passed with little scrutiny Only one hour was spent debating the ban and all three parties agreed meaning no vote was required 101 In an interview conducted in July 2010 when he was no longer a minister Johnson admitted the decision to ban mephedrone was sped up after widespread reporting of deaths caused by the drug and because the government wished to pass the law before parliament was dissolved prior to the upcoming general election 85 In January 2011 however Johnson told the Scunthorpe Telegraph that the decision was based only on information from the ACMD 102 An editorial in the April 2010 edition of The Lancet questioned the decision to ban mephedrone saying the ACMD did not have enough evidence to judge the potential harms caused by mephedrone and arguing that policy makers should have sought to understand why young people took it and how they could be influenced to not take it 90 Evan Harris then the Liberal Democrat science spokesman stated the ACMD was not legally constituted as required by the Misuse of Drugs Act when the report on cathinones was published since after Taylor resigned it lacked a veterinary surgeon 94 In the rush to make mephedrone illegal the act that was passed specified the inactive enantiomer of mephedrone leaving the active form legal until the loophole was closed in February 2011 by another act of parliament 103 In Chemistry World John Mann professor of chemistry at Queen s University Belfast suggested the UK create a law similar to the Federal Analog Act of the United States which would have made mephedrone illegal as an analog of cathinone 104 In August 2010 James Brokenshire the Home Office drugs minister announced plans to create a new category in the Misuse of Drugs Act through the Police Reform and Social Responsibility Bill that would allow new legal highs to be made temporarily illegal without the need for a vote in parliament or advice from the ACMD as was required to categorise mephedrone 105 106 107 According to the Independent Scientific Committee on Drugs after mephedrone was made illegal a street trade in the drug emerged with prices around double those prior to the ban at 20 25 per gram 108 In September 2010 Druglink reported the ban had a mixed effect on mephedrone use with it decreasing in some areas remaining similar in others and becoming more prevalent in some areas 109 In an online survey of 150 users after the ban 63 said they were continuing to use mephedrone of those half claimed unchanged usage amounts as to dosage and frequency and half claimed decreased usage Compared to previous surveys more users purchased it from dealers rather than the internet The average price per gram was 16 compared to around 10 before the ban 110 The 2010 Mixmag survey of 2 500 nightclubbers found one quarter had used mephedrone in the previous month the price had roughly doubled since it was made illegal and it was more likely to be cut with other substances 111 Of those who had already used mephedrone prior to the ban 75 had continued to use it after the ban Of the various drugs used by the survey participants users were more likely to have concerns about it 112 Interviews with users in Northern Ireland also found the price had roughly doubled since it was made illegal to around 30 a gram Rather than the price rising due to increased scarcity of the drug it is thought to have risen for two other reasons Firstly dealers knew there was still demand for mephedrone but were aware the supplies may be exhausted in the future Secondly the dealers perceived customers were likely to be willing to pay more for an illegal substance 13 Professor Shiela Bird a statistician at the Medical Research Council suggested the ban of mephedrone may lead to more cocaine related deaths In the first six months of 2009 the number of cocaine related deaths fell for the first time in four years and fewer soldiers tested positive for cocaine in 2009 than in 2008 She suggested this may have been due to users switching to mephedrone from cocaine but cautioned that before full figures are available for 2009 and 2010 it will be difficult to determine whether mephedrone saved lives rather than cost them 113 114 Other supposedly legal drugs have filled the gap in the market since mephedrone was made illegal including naphyrone NRG 1 since made illegal 115 and Ivory Wave which has been found to contain MDPV a compound made illegal at the same time as mephedrone However some products branded as Ivory Wave possibly do not contain MDPV 116 When tested some products sold six weeks after mephedrone was banned advertised as NRG 1 NRG 2 and MDAI were found to be mephedrone 117 A Drugscope survey of drugs workers at the end of 2012 reported that mephedrone use was still widespread in the UK and that there increasing reports of problematic users It was being taken as not only a poor man s cocaine but also amongst users of heroin and crack cocaine Cases of intravenous use were also reported to be on the increase 118 Society and culture editLegal status edit nbsp A sample of mephedrone that was confiscated in Oregon US 2009 When mephedrone was rediscovered in 2003 it was not specifically illegal to possess in any country As its use has increased many countries have passed legislation making its possession sale and manufacture illegal It was first made illegal in Israel where it had been found in products such as Neodoves pills in January 2008 5 After the death of a young woman in Sweden in December 2008 was linked to the use of mephedrone it was classified as a hazardous substance a few days later making it illegal to sell in Sweden In June 2009 it was classified as a narcotic with the possession of 15 grams or more resulting in a minimum of two years in prison a longer sentence gram for gram than given for the possession of cocaine or heroin 119 120 In December 2008 Denmark also made it illegal 121 and through the Medicines Act of Finland it was made illegal to possess without a prescription 122 In November 2009 it was classified as a narcotic or psychotropic substance and added to the list of controlled substances in Estonia 123 and made illegal to import into Guernsey along with other legal highs 124 before being classified as a Class B drug in April 2010 125 It was classified as a Class C drug in Jersey in December 2009 126 In 2010 as its use became more prevalent many countries passed legislation prohibiting mephedrone It became illegal in Croatia 127 and Germany 128 in January followed by Romania 129 and the Isle of Man in February 130 In March 2010 it was classified as an unregulated medicine in the Netherlands making the sale and distribution of it illegal 131 132 The importation of mephedrone into the UK was banned on 29 March 2010 133 The next day the ACMD in the UK published a report on the cathinones including mephedrone and recommended they be classified as Class B drugs On 7 April 2010 the Misuse of Drugs Act 1971 Amendment Order 2010 was passed by parliament making mephedrone and other substituted cathinones Class B drugs from 16 April 2010 134 135 Prior to the ban taking effect mephedrone was not covered by the Misuse of Drugs Act 1971 71 It was though an offence under the Medicines Act to sell it for human consumption so it was often sold as plant food or bath salts although it has no use as these products this too was possibly illegal under the Trade Descriptions Act 1968 21 22 9 In the US similar descriptions have been used to describe mephedrone as well as methylenedioxypyrovalerone MDPV 136 In May 2010 the Republic of Ireland made mephedrone illegal 137 138 139 followed by Belgium 140 Italy 141 Lithuania 142 France 143 144 and Norway 145 in June and Russia in July 146 In August 2010 Austria 147 and Poland 148 made it illegal and China announced it would be illegal as of 1 September 2010 72 Mephedrone had been reported to be used in Singapore in February 2010 149 but it was made illegal in November 2010 150 In December 2010 following the advice of the EMCDDA mephedrone was made illegal throughout the EU a move Switzerland also made shortly afterwards 151 152 Countries which have not already banned it such as the Netherlands Greece and Portugal will need to change legislation to comply with the EU ruling 152 In Hungary a government advisory body recommended mephedrone should be made illegal in August 2010 which was followed making it illegal in January 2011 153 154 Spain followed in February 2011 155 Mexico by decree 156 outlawed mephedrone as a substance with low or no therapeutical use which pose a serious threat to public health 157 in 2014 In some countries mephedrone is not specifically listed as illegal but is controlled under legislation that makes compounds illegal if they are analogs of drugs already listed In Australia during 2010 it was not specifically listed as prohibited 55 but the Australian Federal Police stated it is an analogue to methcathinone and therefore illegal It is now listed as a Schedule 9 prohibited substance in Australia under the Poisons Standard October 2015 158 A Schedule 9 substance is a substance which may be abused or misused the manufacture possession sale or use of which should be prohibited by law except when required for medical or scientific research or for analytical teaching or training purposes with approval of Commonwealth and or State or Territory Health Authorities 158 In February 2010 22 men were arrested in connection with importing mephedrone 159 By January 2011 every state in Australia other than Victoria had listed it as a controlled drug 160 In New Zealand it is not included in the Misuse of Drugs Act 1975 161 but is illegal as it is similar to controlled substances 162 In Canada mephedrone is not explicitly listed in any schedule of the Controlled Drugs and Substances Act but amphetamines their salts derivatives isomers and analogues and salts of derivatives isomers and analogues are included in Section 19 of Schedule I of the act Cathinone and methcathinone are listed in separate sections of Schedule III while diethylpropion and pyrovalerone also cathinones are listed in separate sections of Schedule IV each without language to capture analogues isomers etc 163 Mephedrone is considered a controlled substance by Health Canada 164 In a report by the Canadian Medical Association in 2010 one lawyer was quoted as suggesting that mephedrone was less popular in Canada than in the U K because there s a provision in the substance act that says analogues of certain drugs and other similar drugs may be illegal too on the other hand the assistant director of the Centre for Addictions Research of British Columbia suggested there was a lack of clear illegality 165 There have been several media reports of the Canadian police seizing mephedrone 166 167 168 but no reports of any successful prosecution of a Controlled Drugs and Substances Act offence implicating mephedrone Mephedrone is also currently scheduled in the United States as of 2011 The Drug Enforcement Administration DEA states as an analogue of methcathinone possession of mephedrone can be controlled by the Federal Analog Act but according to the Los Angeles Times this only applies if it is sold for human consumption 169 170 171 Several cities and states such as New York state 172 have passed legislation to specifically list mephedrone as illegal but in most areas it remained legal so long as it is not sold for human consumption so retailers described it as bath salts 171 In September 2011 The DEA began using its emergency scheduling authority to temporarily control mephedrone Except as authorised by law this action made possessing and selling mephedrone or the products that contain it illegal in the US for at least one year while the DEA and the United States Department of Health and Human Services conduct further study 173 Control of these compounds became permanent on 9 July 2012 via passage of the Synthetic Drug Abuse Prevention Act of 2012 174 Usage edit A survey conducted in late 2009 by the National Addiction Centre UK found 41 3 of readers of Mixmag had used mephedrone in the last month making it the fourth most popular drug amongst clubbers Of those two thirds snorted the drug and the average dosage per session was 0 9 g the length of sessions increased as the dosage increased Users who snorted the drug reported using more per session than those who took it orally 0 97 g compared to 0 74 g and also reported using it more often five days per month compared to three days per month 12 An Irish study of people on a methadone treatment program for heroin addicts found 29 of 209 patients tested positive for mephedrone usage 175 Harm assessment edit Professor David Nutt former chair of the Advisory Council on the Misuse of Drugs ACMD in the UK has said people are better off taking ecstasy or amphetamines than those drugs we know nothing about and Who knows what s in mephedrone when you buy it We don t have a testing system It could be very dangerous we just don t know These chemicals have never been put into animals let alone humans 176 Les King a former member of the ACMD has stated mephedrone appears to be less potent than amphetamine and ecstasy but that any benefit associated with this could be negated by users taking larger amounts He also told the BBC all we can say is mephedrone is probably as harmful as ecstasy and amphetamines and wait until we have some better scientific evidence to support that 52 See also editBath salts 4 Methylamphetamine 4 Methylbuphedrone 4 Methylcathinone 4 Methylpentedrone 4 Methylthioamphetamine Methylenedioxyamphetamine Methamphetamine para MethoxyamphetamineNotes editReferences edit Meyer MR Peters FT Maurer HH 2009 Metabolism of the new designer drug mephedrone and toxicological detection of the beta keto designer drugs mephedrone butylone and methylone in urine PDF Annales de Toxicologie Analytique 21 S1 22 Anvisa 24 July 2023 RDC Nº 804 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 804 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 25 July 2023 Archived from the original on 27 August 2023 Retrieved 27 August 2023 Substance Details 4 Methylmethcathinone Retrieved 22 January 2024 a b c d e f g h i j k l m n o p Europol EMCDDA Joint Report on a new psychoactive substance 4 methylmethcathinone mephedrone European Monitoring Centre for Drugs and Drug Addiction 27 May 2010 Archived from the original PDF on 26 January 2012 Retrieved 29 January 2011 a b c d Cumming E 22 April 2010 Mephedrone Chemistry lessons The Daily Telegraph London Archived from the original on 12 January 2022 Retrieved 14 September 2010 Drugs crackdown hailed a success BBC News 8 March 2010 Retrieved 31 March 2010 Kihara R Day E May 2014 Transient psychotic episodes following recreational use of NRG 3 Progress in Neurology and Psychiatry 18 3 14 18 doi 10 1002 pnp 331 S2CID 70766780 Schifano F Albanese A Fergus S Stair JL Deluca P Corazza O et al April 2011 Mephedrone 4 methylmethcathinone meow meow chemical pharmacological and clinical issues PDF Psychopharmacology 214 3 593 602 doi 10 1007 s00213 010 2070 x hdl 2299 16594 PMID 21072502 S2CID 10529974 a b c Consideration of the cathinones Advisory Council on the Misuse of Drugs 31 March 2010 p 25 Archived from the original on 8 December 2010 Retrieved 10 February 2011 Mephedrone Alcohol and Drug Foundation 10 November 2021 Archived from the original on 18 April 2021 Retrieved 22 November 2021 a b c d Brunt TM Poortman A Niesink RJ van den Brink W November 2011 Instability of the ecstasy market and a new kid on the block mephedrone Journal of Psychopharmacology 25 11 1543 7 doi 10 1177 0269881110378370 PMID 20826554 S2CID 7207426 subscription required a b c Winstock AR Mitcheson LR Deluca P Davey Z Corazza O Schifano F January 2011 Mephedrone new kid for the chop Addiction 106 1 154 61 doi 10 1111 j 1360 0443 2010 03130 x PMID 20735367 a b c d e McElrath K O Neill C March 2011 Experiences with mephedrone pre and post legislative controls perceptions of safety and sources of supply The International Journal on Drug Policy 22 2 120 7 doi 10 1016 j drugpo 2010 11 001 PMID 21242082 subscription required a b Matthews AJ Bruno RB 2010 Mephedrone use among regular ecstasy consumers in Australia PDF Ecstasy and Related Drug Trends Bulletin Archived from the original PDF on 17 February 2011 A joined up approach to drugs is needed now Herald Scotland 21 March 2010 Retrieved 15 September 2010 a b c Gibbons S Zloh M July 2010 An analysis of the legal high mephedrone Bioorganic amp Medicinal Chemistry Letters 20 14 4135 9 doi 10 1016 j bmcl 2010 05 065 PMID 20542690 subscription required Risks of banned drug mephedrone revealed in new research Science Daily 15 July 2010 Retrieved 10 February 2011 Kavanagh PV McNamara S Angelov D McDermott S Mullan D Ryder SA March 2010 The Characterization of Legal Highs Available from Head Shops in Dublin PDF The Drug Treatment Centre Board Retrieved 17 February 2011 Nutt DJ King LA Phillips LD November 2010 Drug harms in the UK a multicriteria decision analysis Lancet 376 9752 1558 1565 CiteSeerX 10 1 1 690 1283 doi 10 1016 S0140 6736 10 61462 6 PMID 21036393 S2CID 5667719 Winstock AR Marsden J Mitcheson L March 2010 What should be done about mephedrone BMJ 340 c1605 doi 10 1136 bmj c1605 PMID 20332508 S2CID 5500659 a b Police warning over bubble drug BBC News 20 November 2009 Retrieved 27 November 2009 a b Reed J 13 January 2010 Clubbers are turning to new legal high mephedrone BBC News Retrieved 4 July 2010 a b James D Adams RD Spears R Cooper G Lupton DJ Thompson JP Thomas SH August 2011 Clinical characteristics of mephedrone toxicity reported to the U K National Poisons Information Service Emergency Medicine Journal 28 8 686 9 doi 10 1136 emj 2010 096636 PMC 3143586 PMID 20798084 Wood DM Greene SL Dargan PI April 2011 Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone Emergency Medicine Journal 28 4 280 2 doi 10 1136 emj 2010 092288 PMID 20581379 S2CID 26029573 subscription required Karch SB January 2015 Cathinone neurotoxicity The 3Ms Current Neuropharmacology 13 1 21 5 doi 10 2174 1570159X13666141210225009 PMC 4462040 PMID 26074741 a b Pantano F Tittarelli R Mannocchi G Pacifici R di Luca A Busardo FP Marinelli E 2017 Neurotoxicity Induced by Mephedrone An up to date Review Current Neuropharmacology 15 5 738 749 doi 10 2174 1570159X14666161130130718 PMC 5771050 PMID 27908258 Mead J Parrott A May 2020 Mephedrone and MDMA A comparative review Brain Res 1735 146740 doi 10 1016 j brainres 2020 146740 PMID 32087112 Kaminska K Noworyta Sokolowska K Gorska A Rzemieniec J Wnuk A Wojtas A Kreiner G Kajta M Golembiowska K October 2018 The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats Neurotox Res 34 3 525 537 doi 10 1007 s12640 018 9908 0 PMC 6154178 PMID 29713996 Wood DM Davies S Puchnarewicz M Button J Archer R Ovaska H et al September 2010 Recreational use of mephedrone 4 methylmethcathinone 4 MMC with associated sympathomimetic toxicity Journal of Medical Toxicology 6 3 327 30 doi 10 1007 s13181 010 0018 5 PMC 3550484 PMID 20358417 subscription required Garrett G Sweeney M September 2010 The serotonin syndrome as a result of mephedrone toxicity BMJ Case Reports 2010 bcr0420102925 doi 10 1136 bcr 04 2010 2925 PMC 3029518 PMID 22778288 subscription required Sammler EM Foley PL Lauder GD Wilson SJ Goudie AR O Riordan JI August 2010 A harmless high Lancet 376 9742 742 doi 10 1016 S0140 6736 10 60891 4 PMID 20801405 S2CID 205959146 subscription required Nicholson PJ Quinn MJ Dodd JD December 2010 Headshop heartache acute mephedrone meow myocarditis Heart 96 24 2051 2 doi 10 1136 hrt 2010 209338 PMID 21062771 S2CID 36684597 subscription required Ahmed N Hoy BP McInerney J October 2010 Methaemoglobinaemia due to mephedrone snow BMJ Case Reports 2010 bcr0420102879 doi 10 1136 bcr 04 2010 2879 PMC 3027398 PMID 22791577 subscription required a b Teenager dies of net drug overdose The Local 15 December 2008 Retrieved 20 September 2010 Gustavsson D Escher C 20 October 2009 Mefedron Internetdrog som tycks ha kommit for att stanna Mephedrone Internet drug that seems to have come to stay Lakartidningen in Swedish Archived from the original on 22 October 2009 Retrieved 21 February 2010 Ghodse H Corkery J Ahmed K Naidoo V Oyefeso A Schifano F July 2010 Drug related deaths in the UK Annual Report 2010 PDF International Centre for Drug Policy St George s University of London p 77 Archived from the original PDF on 29 December 2010 Retrieved 2 January 2010 Man from Hove died after injecting mephedrone BBC News website 27 May 2010 retrieved on 9 June 2012 a b Teenagers deaths not caused by mephedrone BBC News 28 May 2010 Retrieved 20 September 2010 Torrance H Cooper G October 2010 The detection of mephedrone 4 methylmethcathinone in 4 fatalities in Scotland Forensic Science International 202 1 3 e62 3 doi 10 1016 j forsciint 2010 07 014 PMID 20685050 a b c Fleming N 5 April 2010 Mephedrone the anatomy of a media drug scare The Guardian London Retrieved 20 September 2010 Scunthorpe community awash with methadone BBC News 25 January 2011 Retrieved 10 February 2011 a b c d Measham F Moore K Newcombe R Welch Z 12 March 2010 Tweaking bombing dabbing and stockpiling the emergence of mephedrone and the perversity of prohibition Drugs and Alcohol Today 10 1 14 21 doi 10 5042 daat 2010 0123 S2CID 56998007 subscription required Dickson AJ Vorce SP Levine B Past MR April 2010 Multiple drug toxicity caused by the coadministration of 4 methylmethcathinone mephedrone and heroin Journal of Analytical Toxicology 34 3 162 8 doi 10 1093 jat 34 3 162 PMID 20406541 subscription required Darke S Zador D December 1996 Fatal heroin overdose a review Addiction 91 12 1765 72 doi 10 1046 j 1360 0443 1996 911217652 x PMID 8997759 Gregg RA Baumann MH Partilla JS Bonano JS Vouga A Tallarida CS et al February 2015 Stereochemistry of mephedrone neuropharmacology enantiomer specific behavioural and neurochemical effects in rats British Journal of Pharmacology 172 3 883 94 doi 10 1111 bph 12951 PMC 4301696 PMID 25255824 Ciudad Roberts A Camarasa J Ciudad CJ Pubill D Escubedo E October 2015 Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice postulation of unique roles of D3 receptors and BDNF in place preference acquisition British Journal of Pharmacology 172 20 4970 84 doi 10 1111 bph 13266 PMC 4621996 PMID 26228024 Kehr J Ichinose F Yoshitake S Goiny M Sievertsson T Nyberg F Yoshitake T December 2011 Mephedrone compared with MDMA ecstasy and amphetamine rapidly increases both dopamine and 5 HT levels in nucleus accumbens of awake rats British Journal of Pharmacology 164 8 1949 58 doi 10 1111 j 1476 5381 2011 01499 x PMC 3246659 PMID 21615721 Hadlock GC Webb KM McFadden LM Chu PW Ellis JD Allen SC et al November 2011 4 Methylmethcathinone mephedrone neuropharmacological effects of a designer stimulant of abuse The Journal of Pharmacology and Experimental Therapeutics 339 2 530 6 doi 10 1124 jpet 111 184119 PMC 3200001 PMID 21810934 a b Meyer MR Wilhelm J Peters FT Maurer HH June 2010 Beta keto amphetamines studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone butylone and methylone in urine using gas chromatography mass spectrometry Analytical and Bioanalytical Chemistry 397 3 1225 33 doi 10 1007 s00216 010 3636 5 PMID 20333362 S2CID 21471611 subscription required L J Marinetti and H M Antonides Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology method development drug distribution and interpretation of results J Anal Tox 37 135 146 2013 R Baselt Disposition of Toxic Drugs and Chemicals in Man 10th edition Biomedical Publications Seal Beach CA 2014 pp 1226 1227 ISBN 978 0 9626523 9 4 a b Reed J 13 January 2010 What is legal high mephedrone BBC Newsbeat Retrieved 20 September 2010 a b Roussel O Perrin M Herard P Chevance M Arpino P 2009 La 4 methylephedrone sera t elle une Ecstasy du XXIeme siecle Is 4 methylephedrone an Ecstasy of the twenty first century PDF Annales de Toxicologie Analytique in French doi 10 1051 ata 2009048 Psychonaut WebMapping Research Group March 2010 Mephedrone Report PDF Institute of Psychiatry King s College London Archived from the original PDF on 4 July 2011 Retrieved 31 January 2011 a b c Camilleri A Johnston MR Brennan M Davis S Caldicott DG April 2010 Chemical analysis of four capsules containing the controlled substance analogues 4 methylmethcathinone 2 fluoromethamphetamine alpha phthalimidopropiophenone and N ethylcathinone Forensic Science International 197 1 3 59 66 doi 10 1016 j forsciint 2009 12 048 PMID 20074881 subscription required Toole KE Fu S Shimmon RG Kraymen N 2012 Color Tests for the Preliminary Identification of Methcathinone and Analogues of Methcathinone PDF Microgram Journal 9 1 27 32 Archived from the original PDF on 26 November 2013 Retrieved 29 January 2016 Saem de Burnaga Sanchez J 1929 Sur un homologue de l ephedrine On an analogue of ephedrine Bulletin de la Societe Chimique de France in French 45 284 286 Morris H 5 April 2010 Hamilton s Pharmacopeia Mephedrone the phantom menace Vice Magazine Retrieved 4 July 2010 a b c Power M January February 2010 How mephedrone shook the drug world World Wired Web PDF Druglink Drugscope pp 11 13 Archived from the original PDF on 21 August 2010 Retrieved 16 September 2010 Slezak M 10 March 2014 High as a Kiwi Inside the nation saying yes to drugs New Scientist Slezak M 11 August 2014 My recreational drugs can defeat organised crime New Scientist a b c Power M March April 2009 Mephedrone the future of drug dealing PDF Druglink Drugscope pp 6 9 Archived from the original PDF on 21 August 2010 Retrieved 16 September 2010 Doward J Shah O 26 April 2009 There are many drugs that help people get out of their minds yet stay within the law they re called legal highs The Observer Retrieved 28 October 2010 Bentur Y Bloom Krasik A Raikhlin Eisenkraft B March 2008 Illicit cathinone Hagigat poisoning Clinical Toxicology 46 3 206 10 doi 10 1080 15563650701517574 PMID 17852166 S2CID 23603259 subscription required Davies S Ramsey J Archer R November 2009 Analytical profiles of Methcathinone Related Compounds PDF London Toxicology Group Retrieved 22 March 2010 Psychonaut Web Mapping Project Newsletter Psychonaut Web Mapping Project June September 2009 Archived from the original on 16 February 2011 Retrieved 19 December 2009 Guppy D 18 June 2008 Killer pills hit Cairns Cairns com au Retrieved 11 August 2009 Police warn of potentially fatal fake ecstasy Abc net au 17 June 2008 Archived from the original on 10 February 2010 Retrieved 11 August 2009 EMCDDA 2008 Annual Report PDF European Monitoring Centre for Drugs and Drug Addiction Retrieved 26 November 2009 DEA Microgram Bulletin 4 Methylmethcathinone in Oregon PDF The Drug Enforcement Administration July 2009 Archived from the original PDF on 17 October 2010 Retrieved 29 January 2011 a b Devlin K 30 April 2009 Psychiatrists call for legal high drug 4 MMC to be banned The Daily Telegraph London Archived from the original on 26 July 2009 Retrieved 16 September 2010 a b Mephedrone regulated as psychotropic substances State Food and Drug Administration P R China 2 August 2010 Archived from the original on 15 August 2010 Retrieved 12 September 2010 Gammell C 12 March 2009 Legal online drugs providing real alternative to Class A substances The Daily Telegraph London Archived from the original on 12 September 2009 Retrieved 16 September 2010 Campbell D 17 January 2010 Fears grow over safety of legal high mephedrone London The Observer Retrieved 19 March 2010 a b Fleming N 18 March 2010 Briefing Should miaow miaow be banned New Scientist Retrieved 16 September 2010 Designer drug abuse out of control U N drugs board abuse of 4 methyl methcathinone or mephedrone Reuters 2 March 2011 Retrieved 26 March 2012 INCB Annual Report 2010 PDF Report International Narcotics Control Board March 2011 Archived from the original PDF on 2 April 2012 Retrieved 26 March 2012 Dargan P Wood D July 2010 Annex 1 to the Risk assessment report Technical report on mephedrone PDF Report European Monitoring Centre for Drugs and Drug Addiction Archived from the original PDF on 15 July 2011 Retrieved 24 September 2010 Nutt David J 2021 Drugs without the hot air making sense of legal and illegal drugs Second ed Cambridge ISBN 9780857844989 Retrieved 27 September 2022 a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link Extance Andy The rising tide of legal highs Chemistry World Retrieved 27 September 2022 Drug Treatment in 2009 10 PDF Report National Treatment Agency for Substance Misuse October 2010 Archived from the original PDF on 1 March 2011 Retrieved 27 October 2010 a b Fleming N 29 March 2010 Miaow miaow on trial Truth or trumped up charges New Scientist Retrieved 1 April 2010 Reed J 20 June 2010 Newsbeat Ecstasy disappearing from British clubs BBC Retrieved 30 August 2010 The Misuse of Drugs Act 1971 Amendment Order 2009 UK government October 2009 Retrieved 31 January 2011 a b c Silverman J 2010 Addicted to distortion the media and UK drugs policy Safer Communities 9 4 26 31 doi 10 5042 sc 2010 0582 subscription required Inquiries over mephedrone effects Press Association 4 October 2010 Archived from the original on 15 July 2011 Retrieved 27 October 2010 Private Eye Street of Shame No 1259 2 15 April 2010 p 6 Way back in January 2009 not long after mephedrone first began to be sold online members of the web forum attached to the now defunct headshop Champagne Legals discussed what brand name they might attach to the new product which has the chemical identity dimethylmethcathinone or MM Cat What shall we call this drug It s called MM CAT so why not Miaow suggested one The name did not catch on But on 1 November 2009 someone did add the name Meow to the Wikipedia entry for Mephedrone at the head of a list of street names Three weeks later the Sun declared the arrival of a new party favourite called meow meow and the world went cat call crazy Among a host of recent headlines the Sunday Times has reported on the rise of Meow the Times has heralded Meow Meow arrests the Sun shrieked about a Harman snub for Meow Meow Ban and the Daily Telegraph took a long hard look at the Meow Meow Menace in Europe No one ever called it Meow seriously till the papers picked up on the Wikipedia entry one drugs expert tells the Eye Davey Z Corazza O Schifano F Deluca P 2010 Mass information mephedrone myths and the new generation of legal highs Drugs and Alcohol Today 10 3 24 28 doi 10 5042 daat 2010 0467 subscription required Greenslade R 2 December 2010 New guide aims to bring sense to the media coverage of drugs The Guardian Retrieved 19 December 2010 a b Anonymous editorial April 2010 A collapse in integrity of scientific advice in the UK Lancet 375 9723 1319 doi 10 1016 S0140 6736 10 60556 9 PMID 20399965 S2CID 39998854 Silverman J 2010 Addicted to getting drugs wrong British Journalism Review 21 4 31 36 doi 10 1177 0956474810393603 S2CID 143188880 Archived from the original on 12 August 2011 Dargan PI Albert S Wood DM November 2010 Mephedrone use and associated adverse effects in school and college university students before the UK legislation change QJM 103 11 875 9 doi 10 1093 qjmed hcq134 PMID 20675396 Mephedrone to be made Class B drug within weeks BBC News 29 March 2010 Retrieved 31 March 2010 a b Kmietowicz Z March 2010 Home secretary bans mephedrone after taking advice from depleted council BMJ 340 c1784 doi 10 1136 bmj c1784 PMID 20356967 S2CID 8396924 Taylor P 29 March 2010 Drug adviser Dr Polly Taylor s full resignation letter BBC News Retrieved 15 September 2010 Resignation threatens drug ban BBC News 29 March 2010 Retrieved 29 March 2010 Government adviser Eric Carlin resigns over mephedrone BBC News 2 April 2010 Retrieved 2 April 2010 Rolles S 18 March 2010 Mephredone and the ACMD lessons from BZP and New Zealand s Class D experiment Transform Drug Policy Foundation Archived from the original on 15 October 2010 Retrieved 13 April 2010 Doward J 4 April 2010 Mephedrone row grows as seventh member of drugs panel London The Observer Retrieved 15 September 2010 Carlin E 2 April 2010 Eric Carlin s letter of resignation from the ACMD BBC News Retrieved 13 April 2010 Eastwood N June 2010 Legal Eye Mephedrone becomes a class B drug Drugs and Alcohol Today 10 2 6 9 doi 10 5042 daat 2010 0251 subscription required Decision to outlaw mephedrone drug not connected to teen deaths The Scunthorpe Telegraph 27 January 2011 Archived from the original on 8 March 2012 Retrieved 10 February 2011 Nutt D April 2011 Perverse effects of the precautionary principle how banning mephedrone has unexpected implications for pharmaceutical discovery Therapeutic Advances in Psychopharmacology 1 2 35 6 doi 10 1177 2045125311406958 PMC 3736901 PMID 23983925 Mann J April 2010 Can we halt the flow of new designer drugs Chemistry World Retrieved 16 September 2010 Sare J September October 2010 An unchartered course PDF Druglink Drugscope p 5 Archived from the original PDF on 27 September 2011 Retrieved 29 January 2011 Stratton E 8 December 2010 Proposals for banning drugs are more draconian than they seem The Guardian Retrieved 19 December 2010 Van Noorden R 6 December 2010 Science advice not mandatory on drugs council proposes UK government Nature News Archived from the original on 28 December 2010 Retrieved 20 December 2010 Mephedrone harm reduction advice Drugscience org uk Independent Scientific Committee on Drugs 2010 Archived from the original on 2 July 2012 Retrieved 15 September 2010 Daly M September October 2010 Booze bans and bite size bags PDF Druglink Drugscope pp 6 9 Archived from the original PDF on 27 September 2011 Retrieved 29 January 2011 Winstock A Mitcheson L Marsden J November 2010 Mephedrone still available and twice the price Lancet 376 9752 1537 doi 10 1016 S0140 6736 10 62021 1 PMID 21056754 S2CID 41708575 Clubbers still using banned drug mephedrone BBC News 8 February 2011 Retrieved 10 February 2011 Garnett N 9 February 2011 Mephedrone freely available on the internet despite ban BBC Radio 5 Live Retrieved 17 February 2011 Laurance J 24 November 2010 Mephedrone ban blamed for rise in cocaine deaths The Independent Archived from the original on 12 May 2022 Retrieved 20 December 2010 Bird S 22 November 2010 Banned drug may have saved lives not cost them Straight Statistics Retrieved 20 December 2010 NRG 1 legal high drug is banned BBC News 12 July 2010 Retrieved 23 August 2010 Jones S Power M 17 August 2010 Ivory Wave drug implicated in death of 24 year old man The Guardian London Retrieved 23 August 2010 Brandt SD Sumnall HR Measham F Cole J July 2010 Second generation mephedrone The confusing case of NRG 1 BMJ 341 c3564 doi 10 1136 bmj c3564 PMID 20605894 S2CID 20354123 subscription required Daly M December 2012 Drone Strikes PDF Druglink Drugscope pp 8 11 Retrieved 28 March 2013 Svensk forfattningssamling Forordning om andring i forordningen 1999 58 om forbud mot vissa halsofarliga varor Swedish Code of Statutes Regulation amending the Ordinance 1999 58 banning certain hazardous goods PDF in Swedish 25 November 2008 Archived from the original PDF on 5 July 2011 Retrieved 31 January 2011 Stigson G 9 June 2010 15 gram narkotika ger tva ars fangelse 15 grams of drugs means two years in prison in Swedish Dala Demokraten Archived from the original on 19 July 2011 Retrieved 20 September 2010 2009 National Report 2008 data To the EMCDDA by the Reitox National Focal Point Denmark PDF Report 2009 Archived from the original PDF on 15 July 2011 Retrieved 14 September 2010 Rapujuhlat saaristossa Crayfish parties in the archipelago in Finnish City Magazine September 2009 Retrieved 14 September 2010 Estonian Ministry of Social Affairs 8 December 2009 Sotsiaalministri 27 11 2009 maarus number 87 Minister of Social Affairs regulation number 87 in Estonian Archived from the original on 20 July 2011 Retrieved 21 September 2010 Guernsey mephedrone ban only weeks away BBC News 6 April 2010 Retrieved 14 September 2010 Guernsey makes Mephedrone class B drug BBC News 13 April 2010 Retrieved 14 September 2010 Campbell A 4 March 2010 Call to ban legal high mephedrone test change BBC Newsbeat Retrieved 17 March 2010 Dopuna popisa opojnih droga psihotropnih tvari i biljaka iz kojih se moze dobiti opojna droga te tvari koje se mogu uporabiti za izradu opojnih droga List of narcotic drugs psychotropic substances and plants from which narcotic drugs and substances that may be used to manufacture drugs can be obtained in Croatian Croatian Ministry of Health and Social Welfare 28 December 2009 Retrieved 4 July 2010 Vierundzwanzigste Verordnung zur Anderung betaubungsmittelrechtlicher Vorschriften 24th Amendment of narcotics legislation in German Selected laws in Germany Buzer de 22 January 2010 Retrieved 4 July 2010 Romanian Health Ministry 10 February 2010 Comunicat de presă Ministerul Sănătăţii a stabilit lista cu plante si substanţe cu proprietăţi psihoactive care vor fi interzise după ce s au dovedit a fi periculoase pentru sănătate Press release The Health Ministry has established a list of plants and other substances with psychoactive properties that will be banned after it has been proven that they are dangerous to health in Romanian Romanian Health Ministry Archived from the original on 10 February 2011 Retrieved 21 September 2010 Now illegal to import drug plant food to Isle of Man Isle of Man Today 25 February 2010 Archived from the original on 28 February 2010 Retrieved 4 July 2010 Club drug mephedrone faces ban in U K CBC News 29 March 2010 Retrieved 18 March 2014 8 Description of the control measures that are applicable to mephedrone in the Member States Drugtext org Archived from the original on 10 December 2014 Retrieved 18 March 2014 Ilston G 1 April 2010 Mephedrone to be classified a Class B drug Police Professional Archived from the original on 15 July 2011 Retrieved 21 September 2010 BBC Democracy Live MPs move to ban mephedrone BBC News 7 April 2010 Retrieved 8 April 2010 The Misuse of Drugs Amendment England Wales and Scotland Regulations 2010 No 1144 Office of Public Sector Information 16 April 2010 Archived from the original on 5 January 2011 Retrieved 8 April 2010 Victoria Cumbow 6 February 2011 Synthetic form of cocaine and methamphetamine being packaged as bath salts The Huntsville Times Retrieved 10 February 2011 Kelly F 3 March 2010 Head shop substances to be banned Irish Independent Retrieved 21 September 2010 Minister for Health and Children announces immediate criminal ban on list of head shop products Irish Department of Health and Children 11 May 2010 Archived from the original on 21 February 2011 Retrieved 22 August 2010 Gartland F 6 November 2009 Irish youth are fourth highest cocaine users in Europe The Irish Times Archived from the original on 23 October 2010 Retrieved 21 September 2010 Arrete royal du 13 Juin 2010 portant modification de l arrete royal du 22 janvier 1998 reglementant certaines substances psychotropes et relatif a la reduction des risques et a l avis therapeutique Royal Decree of 13 June 2010 amending the Royal Decree of 22 January 1998 regulating certain psychotropic substances therapeutic advice and on reducing risk in French Belgian Department of Justice 13 June 2010 Retrieved 5 July 2010 Tabelle sostanze stupefacenti e psicotrope Table of drugs and psychotropics in Italian Italian Ministry of Health 10 June 2010 Archived from the original on 27 June 2011 Retrieved 2 January 2011 Ministry of Health of the Republic of Lithuania 18 June 2010 2000 m sausio 6 d įsakymo nr 5 del narkotiniu ir psichotropiniu medziagu sarasu patvirtinimo pakeitimo 6 January 2000 Order no 5 of narcotic drugs and psychotropic substances list in Lithuanian Archived from the original on 30 November 2020 Retrieved 21 September 2010 AFP 11 June 2010 Classement comme stupefiant de la mephedrone derivee du khat Classification of mephedrone from khat as a narcotic in French france24 com Archived from the original on 16 June 2010 Retrieved 4 July 2010 La mephedrone classee comme stupefiant Mephedrone classified as a narcotic in French French Ministry of Health and Sports 11 June 2010 Archived from the original on 20 October 2010 Retrieved 26 October 2010 Ti nye stoffer pa narkotikalisten Ten new compounds for drug list in Norwegian Norwegian Broadcasting Corporation NRK 11 June 2010 Archived from the original on 14 June 2010 Retrieved 31 August 2010 Government of the Russian Federation 29 July 2010 Postanovlenie ot 29 iyulya 2010 g 578 Decree of 29 July 2010 number 578 in Russian Archived from the original on 24 July 2011 Retrieved 19 November 2010 Mode Droge Mephedron in Osterreich verboten Fashionable drug mephedrone illegal in Austria in German Die Presse 22 August 2010 Archived from the original on 11 October 2012 Retrieved 22 August 2010 Ustawa z dnia 10 czerwca 2010 r o zmianie ustawy o przeciwdzialaniu narkomanii The Law of 10 June 2010 amending the Act on Counteracting Drug Addiction in Polish Polish Internet Database System of Legal Acts 10 June 2010 Retrieved 25 August 2010 Loh L 24 February 2010 Legal in Singapore the party drug that s banned everywhere else Cnngo com Retrieved 4 July 2010 Yeo A 13 November 2010 Three synthetic drugs to be banned Todayonline Archived from the original on 28 January 2011 Retrieved 16 November 2010 Hermsmeier K 28 August 2010 Ich verfiel der Partydroge Meow I fell into the party drug Meow Archived from the original on 19 July 2011 Retrieved 21 September 2010 a b Impey J 3 December 2010 EU bans meow meow party drug Deutsche Welle Archived from the original on 9 February 2011 Retrieved 19 December 2010 Eldolt betiltjak a katit Decided cathinones banned in Hungarian 2 September 2010 Retrieved 2 January 2011 Magyar kozlony 2010 december 15 Kormanyrendelet a Mephedrone listaravetelerol Hungarian Government bans Mephedrone PDF in Hungarian 15 December 2010 Retrieved 24 January 2011 Documento BOE A 2011 2490 BOE es pp 13595 13596 Retrieved 18 March 2014 DECRETO por el que se reforman las fracciones I y III del articulo 245 de la Ley General de Salud Diario Oficial de la Federacion in Spanish Secretaria de Gobernacion 7 January 2014 Retrieved 1 September 2014 Mexico mephedrone TFMPP and synthetic cannabinoids placed under control United Nations Office on Drugs and Crime United Nations January 2014 Retrieved 1 September 2014 a b Poisons Standard October 2015 https www comlaw gov au Details F2015L01534 Miaow drug seized in mail busts Sydney Morning Herald 12 February 2010 Archived from the original on 1 August 2010 Retrieved 21 September 2010 Levy M 22 January 2011 Judge puts users of new drug on notice The Age Retrieved 17 February 2011 Misuse of Drugs Act 1975 No 116 Public Act New Zealand Legislation New Zealand Ministry of Health 1 December 2009 Archived from the original on 19 May 2011 Retrieved 4 July 2010 Edens J 14 September 2010 Low quality drugs prompt risk warning The Southland Times Archived from the original on 16 September 2010 Retrieved 21 September 2010 Controlled Drugs and Substances Act 1996 c 19 Canadian Department of Justice 20 June 1996 Archived from the original on 6 January 2011 Retrieved 29 January 2011 Chan K 18 March 2010 Mephedrone From plant food to Britain s party drug Globe and Mail Archived from the original on 29 June 2010 Retrieved 23 March 2010 Elwell A June 2010 Britain moves to curtail new drug craze PDF CMAJ 182 9 E393 4 doi 10 1503 cmaj 109 3245 PMC 2882479 PMID 20421358 U K party drug hits St John s streets CBC News 25 June 2010 Retrieved 22 August 2010 McCallum J 18 August 2010 Legal ecstasy causing concern in Quebec The Montreal Gazette Archived from the original on 22 August 2010 Retrieved 22 August 2010 RNC seizes designer drug The Telegram 25 June 2010 Retrieved 22 August 2010 United States Drug Enforcement Administration Drug Scheduling Justice gov Archived from the original on 7 February 2011 Retrieved 4 July 2010 Drugs and Chemicals of Concern 4 Methylmethcathinone United States Drug Enforcement Administration July 2010 Archived from the original on 13 December 2010 Retrieved 21 September 2010 a b Sewell A 28 January 2011 Bath salts latest drug to raise alarms Los Angeles Times Archived from the original on 16 February 2011 Retrieved 17 February 2011 New York State Health Commissioner Bans Sale and Distribution of Dangerous Substances Marketed as Bath Salts New York State Health Department 23 May 2011 Retrieved 22 June 2011 Ferran L 7 September 2011 DEA Announces Emergency Ban on Bath Salts ABC News Retrieved 8 September 2011 Keim B 12 July 2012 New Federal Ban on Synthetic Drugs Already Obsolete Wired Retrieved 18 March 2014 McNamara S Stokes S Coleman N May 2010 Head shop compound abuse amongst attendees of the Drug Treatment Centre Board Irish Medical Journal 103 5 134 136 7 PMID 20666082 Archived from the original on 21 July 2011 Saner E 5 December 2009 Mephedrone and the problem with legal highs The Guardian London Retrieved 20 September 2010 External links editEuropean Monitoring Center for Drugs and Drug Addiction 2011 Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances Report Publications Office doi 10 2810 40800 Erowid 4 Methylmethcathinone Vault Mephedrone Frequently asked questions www lifeline org uk Guardian Daily Podcast How dangerous is mephedrone ChemSub Online Mephedrone Retrieved from https en wikipedia org w index php title Mephedrone amp oldid 1223928710, wikipedia, wiki, book, books, library,

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