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Wikipedia

Immunoglobulin domain

January 01, 1970

The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,[1][2] consisting of about 125 amino acids.

Immunoglobulin domain
Structure of an antigen binding fragment of an antibody.
Identifiers
Symbolig
PfamPF00047
Pfam clanCL0159
InterProIPR013151
PROSITEPDOC00262
SCOP28fab / SCOPe / SUPFAM
OPM superfamily193
OPM protein5f71
CDDcd00096
Membranome2
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions.[3]

Examples edit

Human genes encoding proteins containing the immunoglobulin domain include:

See also edit

References edit

  1. ^ Bork P, Holm L, Sander C (September 1994). "The immunoglobulin fold. Structural classification, sequence patterns and common core". J. Mol. Biol. 242 (4): 309–20. doi:10.1006/jmbi.1994.1582. PMID 7932691.
  2. ^ Brümmendorf T, Rathjen FG (1995). "Cell adhesion molecules 1: immunoglobulin superfamily". Protein Profile. 2 (9): 963–1108. PMID 8574878.
  3. ^ Williams AF, Barclay AN (1988). "The immunoglobulin superfamily—domains for cell surface recognition". Annu. Rev. Immunol. 6: 381–405. doi:10.1146/annurev.iy.06.040188.002121. PMID 3289571.

External links edit

    This article incorporates text from the public domain Pfam and InterPro: IPR013151

    January 01, 1970
    immunoglobulin, domain, immunoglobulin, domain, also, known, immunoglobulin, fold, type, protein, domain, that, consists, layer, sandwich, antiparallel, strands, arranged, sheets, with, greek, topology, consisting, about, amino, acids, structure, antigen, bind. The immunoglobulin domain also known as the immunoglobulin fold is a type of protein domain that consists of a 2 layer sandwich of 7 9 antiparallel b strands arranged in two b sheets with a Greek key topology 1 2 consisting of about 125 amino acids Immunoglobulin domainStructure of an antigen binding fragment of an antibody IdentifiersSymboligPfamPF00047Pfam clanCL0159InterProIPR013151PROSITEPDOC00262SCOP28fab SCOPe SUPFAMOPM superfamily193OPM protein5f71CDDcd00096Membranome2Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary The backbone switches repeatedly between the two b sheets Typically the pattern is N terminal b hairpin in sheet 1 b hairpin in sheet 2 b strand in sheet 1 C terminal b hairpin in sheet 2 The cross overs between sheets form an X so that the N and C terminal hairpins are facing each other Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions Examples include antibodies the giant muscle kinase titin and receptor tyrosine kinases Immunoglobulin like domains may be involved in protein protein and protein ligand interactions 3 Contents 1 Examples 2 See also 3 References 4 External linksExamples editHuman genes encoding proteins containing the immunoglobulin domain include A1BG ACAM ADAMTSL1 ADAMTSL3 AGER ALCAM AMIGO1 AMIGO2 AXL BCAM BOC BSG BTLA C10orf72 C20orf102 CADM1 CADM3 CD200 CD22 CD276 CD33 CD4 CDON CEACAM1 CEACAM16 CEACAM20 CEACAM21 CEACAM5 CEACAM6 CEACAM8 CHL1 CILP CNTFR CNTN1 CNTN2 CNTN3 CNTN4 CNTN5 CNTN6 CSF1R DSCAM DSCAML1 EMB F11R FAIM3 FCAR FCER1A FCGR1A FCGR2A FCGR2B FCGR2C FCGR3A FCGR3B FCRH1 FCRH3 FCRH4 FCRL1 FCRL2 FCRL3 FCRL4 FCRL5 FCRL6 FCRLA FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FLT1 FLT3 FLT4 FSTL4 FSTL5 GP6 GPA33 GPR116 GPR125 HEPACAM HLA DMA HLA DMB HLA DQB HLA DQB1 HMCN1 HNT HSPG2 HYST2477 ICAM3 ICAM5 IGHA1 IGHD IGHE IGSF10 IGSF11 IGSF2 IGSF21 IGSF3 IGSF9 IL11RA IL1R1 IL1R2 IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 IL6R JAM2 JAM3 KIR 123FM KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DL5A KIR2DL5B KIR2DLX KIR2DS1 KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DL2 KIR3DL3 KIR3DS1 KIT L1CAM LAG3 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 LILRA6 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LILRP2 LRIG1 LRIG2 LRIG3 LRIT1 LRRC4 LSAMP MAG MALT1 MCAM MDGA1 MDGA2 MERTK MFAP3 MIR MIR MXRA5 MYBPC3 MYOM1 MYOM3 NCA NCAM1 NCAM2 NEGR1 NEO1 NFASC NOPE NPHS1 NPTN NRCAM NRG1 NT NTRK3 OBSCN OBSL1 OPCML PAPLN PDGFRA PDGFRB PDGFRL PECAM1 PRODH2 PSG1 PSG10 PSG11 PSG11s PSG2 PSG3 PSG4 PSG5 PSG6 PSG7 PSG8 PSG9 PTGFRN PTK7 PTPRD PTPRK PTPRM PTPRS PTPsigma PUNC PVR PVRL1 PVRL2 PVRL4 RAGE SCN1B SDK1 SDK2 SEMA3A SEMA3B SEMA3E SEMA3F SEMA3G SEMA4D SIGLEC1 SIGLEC10 SIGLEC11 SIGLEC12 SIGLEC14 SIGLEC6 SIGLEC7 SIGLEC8 SIRPG THY1 TIE1 TMIGD1 TMIGD2 TTN TYRO3 UNC5D VCAM1 VSIG1 VSIG2 VSIG4 hEMMPRIN kir3dSee also editImmunoglobulin superfamilyReferences edit Bork P Holm L Sander C September 1994 The immunoglobulin fold Structural classification sequence patterns and common core J Mol Biol 242 4 309 20 doi 10 1006 jmbi 1994 1582 PMID 7932691 Brummendorf T Rathjen FG 1995 Cell adhesion molecules 1 immunoglobulin superfamily Protein Profile 2 9 963 1108 PMID 8574878 Williams AF Barclay AN 1988 The immunoglobulin superfamily domains for cell surface recognition Annu Rev Immunol 6 381 405 doi 10 1146 annurev iy 06 040188 002121 PMID 3289571 External links editSCOP listing of immunoglobulin domains of known structure This article incorporates text from the public domain Pfam and InterPro IPR013151 Retrieved from https en wikipedia org w index php title Immunoglobulin domain amp oldid 1214980189, wikipedia, wiki, book, books, library,

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