fbpx
Wikipedia

LILRB4

April 12, 2024

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.[5][6][7]

LILRB4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLILRB4, CD85K, ILT-3, ILT3, LIR-5, LIR5, leukocyte immunoglobulin like receptor B4, B4
External IDsOMIM: 604821 MGI: 102702 HomoloGene: 86756 GeneCards: LILRB4
Orthologs
SpeciesHumanMouse
Entrez

11006

14727

Ensembl

ENSMUSG00000112023

UniProt

Q8NHJ6

Q61450

RefSeq (mRNA)

NM_001291892
NM_001291893
NM_008147

RefSeq (protein)

NP_001265355
NP_001265356
NP_001265357
NP_001265358
NP_001265359

NP_001278821
NP_001278822
NP_032173

Location (UCSC)Chr 19: 54.64 – 54.67 MbChr 10: 51.36 – 51.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. LILRB4 has also been proposed to be a potential target for tumor immunotherapy. It has been shown to express on tumor-associated macrophages and negatively regulate immune response in tumor.[8] The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions edit

LILRB4 has been shown to interact with PTPN6[9] and INPP5D (SHIP-1).[10]

See also edit

References edit

  1. ^ a b c ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 GRCh38: Ensembl release 89: ENSG00000275730, ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000112023 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
  6. ^ Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
  7. ^ a b "Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4".
  8. ^ Sharma N, Atolagbe OT, Ge Z, Allison JP (July 2021). "LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy". The Journal of Experimental Medicine. 218 (7). doi:10.1084/jem.20201811. PMC 8117208. PMID 33974041.
  9. ^ Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. doi:10.4049/jimmunol.162.3.1318. PMID 9973385.
  10. ^ Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, et al. (November 2017). "Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia". Blood. 130 (18): 2006–2017. doi:10.1182/blood-2017-03-775858. PMID 28931525.

Further reading edit

  • Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. (October 2018). "LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration". Nature. 562 (7728): 605–609. Bibcode:2018Natur.562..605D. doi:10.1038/s41586-018-0615-z. PMC 6296374. PMID 30333625.
  • John S, Chen H, Deng M, Gui X, Wu G, Chen W, Li Z, Zhang N, An Z, Zhang CC (October 2018). "A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML". Molecular Therapy. 26 (10): 2487–2495. doi:10.1016/j.ymthe.2018.08.001. PMC 6171100. PMID 30131301.
  • Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, et al. (August 2019). "Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development". Cancer Immunology Research. 7 (8): 1244–1257. doi:10.1158/2326-6066.CIR-19-0036. PMC 6677629. PMID 31213474.
  • Suciu-Foca N, Cortesini R (July 2007). "Central role of ILT3 in the T suppressor cell cascade". Cellular Immunology. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
  • Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324.
  • Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, et al. (January 1998). "Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene". The Journal of Biological Chemistry. 273 (2): 1070–4. doi:10.1074/jbc.273.2.1070. PMID 9422771.
  • Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
  • Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (December 1998). "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex". European Journal of Immunology. 28 (12): 3959–67. doi:10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2. PMID 9862332.
  • Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. doi:10.4049/jimmunol.162.3.1318. PMID 9973385.
  • Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, et al. (April 2000). "Plasticity in the organization and sequences of human KIR/ILT gene families". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4778–83. Bibcode:2000PNAS...97.4778W. doi:10.1073/pnas.080588597. PMC 18309. PMID 10781084.
  • Heinzmann A, Blattmann S, Forster J, Kuehr J, Deichmann KA (June 2000). "Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy". European Journal of Immunogenetics. 27 (3): 121–7. doi:10.1046/j.1365-2370.2000.00214.x. PMID 10940079.
  • Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP (July 2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". Immunogenetics. 51 (8–9): 659–69. doi:10.1007/s002510000183. PMID 10941837. S2CID 23687483.
  • Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.
  • Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature Immunology. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462. S2CID 35400503.
  • LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED (April 2005). "HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells". FASEB Journal. 19 (6): 662–4. doi:10.1096/fj.04-1617fje. PMID 15670976. S2CID 24608530.
  • Garner LI, Salim M, Mohammed F, Willcox BE (June 2006). "Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies". Protein Expression and Purification. 47 (2): 490–7. doi:10.1016/j.pep.2005.11.020. PMID 16406677.
  • Kim-Schulze S, Seki T, Vlad G, Scotto L, Fan J, Colombo PC, et al. (January 2006). "Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells". American Journal of Transplantation. 6 (1): 76–82. doi:10.1111/j.1600-6143.2005.01162.x. PMID 16433759. S2CID 7662795.
  • Kim-Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, et al. (March 2006). "Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells". Journal of Immunology. 176 (5): 2790–8. doi:10.4049/jimmunol.176.5.2790. PMID 16493035.
  • Vlad G, Liu Z, Zhang QY, Cortesini R, Suciu-Foca N (December 2006). "Immunosuppressive activity of recombinant ILT3". International Immunopharmacology. 6 (13–14): 1889–94. doi:10.1016/j.intimp.2006.07.017. PMID 17161342.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This immunology article is a stub. You can help Wikipedia by expanding it.

 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

April 12, 2024
lilrb4, leukocyte, immunoglobulin, like, receptor, subfamily, member, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3p2tidentifiersaliases, cd85k, ilt3, lir5, leukocyte, immunoglobulin, like, receptor, b4e. Leukocyte immunoglobulin like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene 5 6 7 LILRB4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3P2TIdentifiersAliasesLILRB4 CD85K ILT 3 ILT3 LIR 5 LIR5 leukocyte immunoglobulin like receptor B4 B4External IDsOMIM 604821 MGI 102702 HomoloGene 86756 GeneCards LILRB4Gene location Human Chr Chromosome 19 human 1 Band19q13 42Start54 643 889 bp 1 End54 670 359 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 B3Start51 356 728 bp 2 End51 362 799 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inappendixmonocytelymph nodebloodspleengallbladderplacentabone marrowsubstantia nigraupper lobe of left lungTop expressed inbone marrowzone of skinovarywhite adipose tissueliveruteruslungspleenlipjejunumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionantigen binding protein binding signaling receptor activityCellular componentextracellular exosome plasma membrane membrane integral component of membraneBiological processnegative regulation of pri miRNA transcription by RNA polymerase II immune system process adaptive immune response signal transduction negative regulation of osteoclast differentiation positive regulation of regulatory T cell differentiation negative regulation of T cell receptor signaling pathway negative regulation of protein localization to nucleusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1100614727EnsemblENSG00000275730ENSG00000186818ENSG00000276042ENSG00000278279ENSG00000278555n aENSMUSG00000112023UniProtQ8NHJ6Q61450RefSeq mRNA NM 001081438NM 001278426NM 001278427NM 001278428NM 001278429NM 001278430NM 006847NM 001394933NM 001394934NM 001394935NM 001394936NM 001394937NM 001394938NM 001394939NM 001291892NM 001291893NM 008147RefSeq protein NP 001265355NP 001265356NP 001265357NP 001265358NP 001265359NP 001278821NP 001278822NP 032173Location UCSC Chr 19 54 64 54 67 MbChr 10 51 36 51 36 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is a member of the leukocyte immunoglobulin like receptor LIR family which is found in a gene cluster at chromosomal region 19q13 4 The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains a transmembrane domain and two to four cytoplasmic immunoreceptor tyrosine based inhibitory motifs ITIMs The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response The receptor can also function in antigen capture and presentation It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity LILRB4 has also been proposed to be a potential target for tumor immunotherapy It has been shown to express on tumor associated macrophages and negatively regulate immune response in tumor 8 The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation Multiple transcript variants encoding different isoforms have been found for this gene 7 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editLILRB4 has been shown to interact with PTPN6 9 and INPP5D SHIP 1 10 See also editCluster of differentiation Immunoglobulin superfamilyReferences edit a b c ENSG00000186818 ENSG00000276042 ENSG00000278279 ENSG00000278555 GRCh38 Ensembl release 89 ENSG00000275730 ENSG00000186818 ENSG00000276042 ENSG00000278279 ENSG00000278555 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000112023 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cella M Dohring C Samaridis J Dessing M Brockhaus M Lanzavecchia A Colonna M May 1997 A novel inhibitory receptor ILT3 expressed on monocytes macrophages and dendritic cells involved in antigen processing The Journal of Experimental Medicine 185 10 1743 51 doi 10 1084 jem 185 10 1743 PMC 2196312 PMID 9151699 Samaridis J Colonna M March 1997 Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells structural evidence for new stimulatory and inhibitory pathways European Journal of Immunology 27 3 660 5 doi 10 1002 eji 1830270313 PMID 9079806 S2CID 2212182 a b Entrez Gene LILRB4 leukocyte immunoglobulin like receptor subfamily B with TM and ITIM domains member 4 Sharma N Atolagbe OT Ge Z Allison JP July 2021 LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy The Journal of Experimental Medicine 218 7 doi 10 1084 jem 20201811 PMC 8117208 PMID 33974041 Wang LL Blasioli J Plas DR Thomas ML Yokoyama WM February 1999 Specificity of the SH2 domains of SHP 1 in the interaction with the immunoreceptor tyrosine based inhibitory motif bearing receptor gp49B Journal of Immunology 162 3 1318 23 doi 10 4049 jimmunol 162 3 1318 PMID 9973385 Zurli V Wimmer G Cattaneo F Candi V Cencini E Gozzetti A et al November 2017 Ectopic ILT3 controls BCR dependent activation of Akt in B cell chronic lymphocytic leukemia Blood 130 18 2006 2017 doi 10 1182 blood 2017 03 775858 PMID 28931525 Further reading editDeng M Gui X Kim J Xie L Chen W Li Z et al October 2018 LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration Nature 562 7728 605 609 Bibcode 2018Natur 562 605D doi 10 1038 s41586 018 0615 z PMC 6296374 PMID 30333625 John S Chen H Deng M Gui X Wu G Chen W Li Z Zhang N An Z Zhang CC October 2018 A Novel Anti LILRB4 CAR T Cell for the Treatment of Monocytic AML Molecular Therapy 26 10 2487 2495 doi 10 1016 j ymthe 2018 08 001 PMC 6171100 PMID 30131301 Gui X Deng M Song H Chen Y Xie J Li Z et al August 2019 Disrupting LILRB4 APOE Interaction by an Efficacious Humanized Antibody Reverses T cell Suppression and Blocks AML Development Cancer Immunology Research 7 8 1244 1257 doi 10 1158 2326 6066 CIR 19 0036 PMC 6677629 PMID 31213474 Suciu Foca N Cortesini R July 2007 Central role of ILT3 in the T suppressor cell cascade Cellular Immunology 248 1 59 67 doi 10 1016 j cellimm 2007 01 013 PMID 17923119 Arm JP Nwankwo C Austen KF September 1997 Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor Journal of Immunology 159 5 2342 9 doi 10 4049 jimmunol 159 5 2342 PMID 9278324 Kuroiwa A Yamashita Y Inui M Yuasa T Ono M Nagabukuro A et al January 1998 Association of tyrosine phosphatases SHP 1 and SHP 2 inositol 5 phosphatase SHIP with gp49B1 and chromosomal assignment of the gene The Journal of Biological Chemistry 273 2 1070 4 doi 10 1074 jbc 273 2 1070 PMID 9422771 Borges L Hsu ML Fanger N Kubin M Cosman D December 1997 A family of human lymphoid and myeloid Ig like receptors some of which bind to MHC class I molecules Journal of Immunology 159 11 5192 6 doi 10 4049 jimmunol 159 11 5192 PMID 9548455 Torkar M Norgate Z Colonna M Trowsdale J Wilson MJ December 1998 Isotypic variation of novel immunoglobulin like transcript killer cell inhibitory receptor loci in the leukocyte receptor complex European Journal of Immunology 28 12 3959 67 doi 10 1002 SICI 1521 4141 199812 28 12 lt 3959 AID IMMU3959 gt 3 0 CO 2 2 PMID 9862332 Wang LL Blasioli J Plas DR Thomas ML Yokoyama WM February 1999 Specificity of the SH2 domains of SHP 1 in the interaction with the immunoreceptor tyrosine based inhibitory motif bearing receptor gp49B Journal of Immunology 162 3 1318 23 doi 10 4049 jimmunol 162 3 1318 PMID 9973385 Wilson MJ Torkar M Haude A Milne S Jones T Sheer D et al April 2000 Plasticity in the organization and sequences of human KIR ILT gene families Proceedings of the National Academy of Sciences of the United States of America 97 9 4778 83 Bibcode 2000PNAS 97 4778W doi 10 1073 pnas 080588597 PMC 18309 PMID 10781084 Heinzmann A Blattmann S Forster J Kuehr J Deichmann KA June 2000 Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy European Journal of Immunogenetics 27 3 121 7 doi 10 1046 j 1365 2370 2000 00214 x PMID 10940079 Liu WR Kim J Nwankwo C Ashworth LK Arm JP July 2000 Genomic organization of the human leukocyte immunoglobulin like receptors within the leukocyte receptor complex on chromosome 19q13 4 Immunogenetics 51 8 9 659 69 doi 10 1007 s002510000183 PMID 10941837 S2CID 23687483 Young NT Canavez F Uhrberg M Shum BP Parham P 2001 Conserved organization of the ILT LIR gene family within the polymorphic human leukocyte receptor complex Immunogenetics 53 4 270 8 doi 10 1007 s002510100332 PMID 11491530 S2CID 2819935 Chang CC Ciubotariu R Manavalan JS Yuan J Colovai AI Piazza F et al March 2002 Tolerization of dendritic cells by T S cells the crucial role of inhibitory receptors ILT3 and ILT4 Nature Immunology 3 3 237 43 doi 10 1038 ni760 PMID 11875462 S2CID 35400503 LeMaoult J Zafaranloo K Le Danff C Carosella ED April 2005 HLA G up regulates ILT2 ILT3 ILT4 and KIR2DL4 in antigen presenting cells NK cells and T cells FASEB Journal 19 6 662 4 doi 10 1096 fj 04 1617fje PMID 15670976 S2CID 24608530 Garner LI Salim M Mohammed F Willcox BE June 2006 Expression purification and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin like receptor 5 for structural and ligand identification studies Protein Expression and Purification 47 2 490 7 doi 10 1016 j pep 2005 11 020 PMID 16406677 Kim Schulze S Seki T Vlad G Scotto L Fan J Colombo PC et al January 2006 Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells American Journal of Transplantation 6 1 76 82 doi 10 1111 j 1600 6143 2005 01162 x PMID 16433759 S2CID 7662795 Kim Schulze S Scotto L Vlad G Piazza F Lin H Liu Z et al March 2006 Recombinant Ig like transcript 3 Fc modulates T cell responses via induction of Th anergy and differentiation of CD8 T suppressor cells Journal of Immunology 176 5 2790 8 doi 10 4049 jimmunol 176 5 2790 PMID 16493035 Vlad G Liu Z Zhang QY Cortesini R Suciu Foca N December 2006 Immunosuppressive activity of recombinant ILT3 International Immunopharmacology 6 13 14 1889 94 doi 10 1016 j intimp 2006 07 017 PMID 17161342 External links editLILRB4 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This immunology article is a stub You can help Wikipedia by expanding it vte nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LILRB4 amp oldid 1217393948, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.