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MYOM1

May 02, 2024

Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.[5][6] Myomesin-1 is expressed in muscle cells and functions to stabilize the three-dimensional conformation of the thick filament. Embryonic forms of Myomesin-1 have been detected in dilated cardiomyopathy.

MYOM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYOM1, SKELEMIN, myomesin 1
External IDsOMIM: 603508 MGI: 1341430 HomoloGene: 31196 GeneCards: MYOM1
Orthologs
SpeciesHumanMouse
Entrez

8736

17929

Ensembl

ENSG00000101605

ENSMUSG00000024049

UniProt

P52179

Q62234

RefSeq (mRNA)

NM_003803
NM_019856

NM_001083934
NM_010867

RefSeq (protein)

NP_003794
NP_062830

NP_001077403
NP_034997

Location (UCSC)Chr 18: 3.07 – 3.22 MbChr 17: 71.31 – 71.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure edit

Alternatively spliced variants of MYOM1, including EH-myomesin,[7] Skelemin[8] and Myomesin-1[8][9][10] have been identified; with Skelemin having an additional 96 amino acids rich in serine and proline residues.[8] Myomesin-1, like myomesin 2 and titin, is a member of a family of myosin-associated proteins containing structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin-1 bears uniqueness within this family in that it has intermediate filament core-like motifs, one near each terminus.[11] Myomesin-1 and Myomesin-2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. Alternatively spliced, tissue-specific transcript variants encoding different isoforms have been identified.[12] Myomesin-1 can dimerize in an anti-parallel fashion via its C-terminal region.[13]

Function edit

Titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to Myomesin-1 and myomesin 2. Skelemin/Myomesin-1 is concentrated at peripheral regions of M-bands, and is postulated to link myofibrils with the intermediate filament cytoskeleton.[11] Skelemin/Myomesin-1 has been detected in the nucleus as well as the cytoskeletal, suggesting that it may play a role in gene expression.[14] Myomesin-1 functions to mediate stretch-induced signaling,[15] and the EH-myomesin splice variant, expressed in embryonic hearts and in dilated cardiomyopathy, can modulate its elasticity.[16]

Clinical Significance edit

The fetal EH-myomesin alternatively spliced form of MYOM1 has been shown to be reexpressed at an early timepoint in the progression of dilated cardiomyopathy, coincident with isoform switches in titin.[17]

MYOM1 has also been shown to be abnormally spliced in patients with myotonic dystrophy type I; specifically, exon 17a.[18]

Interactions edit

Skelemin/Myomesin-1 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101605 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024049 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Speel EJ, van der Ven PF, Albrechts JC, Ramaekers FC, Fürst DO, Hopman AH (Nov 1998). "Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32". Genomics. 54 (1): 184–6. doi:10.1006/geno.1998.5503. PMID 9806852.
  6. ^ "Entrez Gene: MYOM1 myomesin 1 (skelemin) 185kDa".
  7. ^ Agarkova I, Auerbach D, Ehler E, Perriard JC (Apr 2000). "A novel marker for vertebrate embryonic heart, the EH-myomesin isoform". The Journal of Biological Chemistry. 275 (14): 10256–64. doi:10.1074/jbc.275.14.10256. PMID 10744711.
  8. ^ a b c Steiner F, Weber K, Fürst DO (Feb 1999). "M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression". Genomics. 56 (1): 78–89. doi:10.1006/geno.1998.5682. PMID 10036188.
  9. ^ . Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 24 June 2015. Retrieved 24 June 2015.
  10. ^ . Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 24 June 2015. Retrieved 24 June 2015.
  11. ^ a b Price MG, Gomer RH (Oct 1993). "Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins". The Journal of Biological Chemistry. 268 (29): 21800–10. doi:10.1016/S0021-9258(20)80613-9. PMID 8408035.
  12. ^ Bantle S, Keller S, Haussmann I, Auerbach D, Perriard E, Mühlebach S, Perriard JC (Aug 1996). "Tissue-specific isoforms of chicken myomesin are generated by alternative splicing". The Journal of Biological Chemistry. 271 (32): 19042–52. doi:10.1074/jbc.271.32.19042. PMID 8702575.
  13. ^ Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E (Jan 2005). "Dimerisation of myomesin: implications for the structure of the sarcomeric M-band". Journal of Molecular Biology. 345 (2): 289–98. doi:10.1016/j.jmb.2004.10.040. PMID 15571722.
  14. ^ Reddy KB, Fox JE, Price MG, Kulkarni S, Gupta S, Das B, Smith DM (2008). "Nuclear localization of Myomesin-1: possible functions". Journal of Muscle Research and Cell Motility. 29 (1): 1–8. doi:10.1007/s10974-008-9137-x. PMID 18521710. S2CID 12298270.
  15. ^ Agarkova I, Perriard JC (Sep 2005). "The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere". Trends in Cell Biology. 15 (9): 477–85. CiteSeerX 10.1.1.384.2007. doi:10.1016/j.tcb.2005.07.001. PMID 16061384.
  16. ^ Schoenauer R, Bertoncini P, Machaidze G, Aebi U, Perriard JC, Hegner M, Agarkova I (Jun 2005). "Myomesin is a molecular spring with adaptable elasticity". Journal of Molecular Biology. 349 (2): 367–79. doi:10.1016/j.jmb.2005.03.055. PMID 15890201.
  17. ^ Schoenauer R, Emmert MY, Felley A, Ehler E, Brokopp C, Weber B, Nemir M, Faggian GG, Pedrazzini T, Falk V, Hoerstrup SP, Agarkova I (Mar 2011). "EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy". Basic Research in Cardiology. 106 (2): 233–47. doi:10.1007/s00395-010-0131-2. PMC 3032906. PMID 21069531.
  18. ^ Koebis M, Ohsawa N, Kino Y, Sasagawa N, Nishino I, Ishiura S (Sep 2011). "Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1". Genes to Cells. 16 (9): 961–72. doi:10.1111/j.1365-2443.2011.01542.x. PMID 21794030. S2CID 3272510.
  19. ^ a b Reddy KB, Gascard P, Price MG, Negrescu EV, Fox JE (Dec 1998). "Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells". The Journal of Biological Chemistry. 273 (52): 35039–47. doi:10.1074/jbc.273.52.35039. PMID 9857037.
  20. ^ a b Deshmukh L, Tyukhtenko S, Liu J, Fox JE, Qin J, Vinogradova O (Nov 2007). "Structural insight into the interaction between platelet integrin alphaIIbbeta3 and cytoskeletal protein skelemin". The Journal of Biological Chemistry. 282 (44): 32349–56. doi:10.1074/jbc.M704666200. PMID 17804417.
  21. ^ a b Obermann WM, Gautel M, Weber K, Fürst DO (Jan 1997). "Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin". The EMBO Journal. 16 (2): 211–20. doi:10.1093/emboj/16.2.211. PMC 1169628. PMID 9029142.
  22. ^ Obermann WM, van der Ven PF, Steiner F, Weber K, Fürst DO (Apr 1998). "Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band". Molecular Biology of the Cell. 9 (4): 829–40. doi:10.1091/mbc.9.4.829. PMC 25310. PMID 9529381.
  23. ^ Auerbach D, Bantle S, Keller S, Hinderling V, Leu M, Ehler E, Perriard JC (May 1999). "Different domains of the M-band protein myomesin are involved in myosin binding and M-band targeting". Molecular Biology of the Cell. 10 (5): 1297–308. doi:10.1091/mbc.10.5.1297. PMC 25262. PMID 10233145.
  24. ^ Li TB, Liu XH, Feng S, Hu Y, Yang WX, Han Y, Wang YG, Gong LM (Jun 2004). (PDF). Acta Biochimica et Biophysica Sinica. 36 (6): 412–8. doi:10.1093/abbs/36.6.412. PMID 15188056. S2CID 18331104. Archived from the original (PDF) on 2019-02-22.

Further reading edit

  • Grove BK, Kurer V, Lehner C, Doetschman TC, Perriard JC, Eppenberger HM (Feb 1984). "A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies". The Journal of Cell Biology. 98 (2): 518–24. doi:10.1083/jcb.98.2.518. PMC 2113097. PMID 6537951.
  • Vinkemeier U, Obermann W, Weber K, Fürst DO (Sep 1993). "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins". Journal of Cell Science. 106 (1): 319–30. doi:10.1242/jcs.106.1.319. PMID 7505783.
  • Obermann WM, Plessmann U, Weber K, Fürst DO (Oct 1995). "Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle". European Journal of Biochemistry. 233 (1): 110–5. doi:10.1111/j.1432-1033.1995.110_1.x. PMID 7588733.
  • Steiner F, Weber K, Fürst DO (Feb 1999). "M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression". Genomics. 56 (1): 78–89. doi:10.1006/geno.1998.5682. PMID 10036188.
  • Agarkova I, Auerbach D, Ehler E, Perriard JC (Apr 2000). "A novel marker for vertebrate embryonic heart, the EH-myomesin isoform". The Journal of Biological Chemistry. 275 (14): 10256–64. doi:10.1074/jbc.275.14.10256. PMID 10744711.
  • Porter JD, Merriam AP, Gong B, Kasturi S, Zhou X, Hauser KF, Andrade FH, Cheng G (Sep 2003). "Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle". The Journal of Experimental Biology. 206 (Pt 17): 3101–12. doi:10.1242/jeb.00511. PMID 12878677. S2CID 21867785.
  • Hornemann T, Kempa S, Himmel M, Hayess K, Fürst DO, Wallimann T (Sep 2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein". Journal of Molecular Biology. 332 (4): 877–87. doi:10.1016/S0022-2836(03)00921-5. PMID 12972258.
  • Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E (Jan 2005). "Dimerisation of myomesin: implications for the structure of the sarcomeric M-band". Journal of Molecular Biology. 345 (2): 289–98. doi:10.1016/j.jmb.2004.10.040. PMID 15571722.
  • Schoenauer R, Bertoncini P, Machaidze G, Aebi U, Perriard JC, Hegner M, Agarkova I (Jun 2005). "Myomesin is a molecular spring with adaptable elasticity". Journal of Molecular Biology. 349 (2): 367–79. doi:10.1016/j.jmb.2005.03.055. PMID 15890201.

May 02, 2024
myom1, myomesin, protein, that, humans, encoded, gene, myomesin, expressed, muscle, cells, functions, stabilize, three, dimensional, conformation, thick, filament, embryonic, forms, myomesin, have, been, detected, dilated, cardiomyopathy, available, structures. Myomesin 1 is a protein that in humans is encoded by the MYOM1 gene 5 6 Myomesin 1 is expressed in muscle cells and functions to stabilize the three dimensional conformation of the thick filament Embryonic forms of Myomesin 1 have been detected in dilated cardiomyopathy MYOM1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2R15 2Y23 2Y25 3RBSIdentifiersAliasesMYOM1 SKELEMIN myomesin 1External IDsOMIM 603508 MGI 1341430 HomoloGene 31196 GeneCards MYOM1Gene location Human Chr Chromosome 18 human 1 Band18p11 31Start3 066 807 bp 1 End3 219 968 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 E1 3Start71 309 628 bp 2 End71 433 851 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscletriceps brachii muscleleft ventriclevastus lateralis muscledeltoid musclethoracic diaphragmtibialis anterior muscleright ventriclebody of tongueright coronary arteryTop expressed intriceps brachii muscletemporal musclesternocleidomastoid muscledigastric muscletriceps suraegastrocnemius musclevastus lateralis muscletibialis anterior muscleextensor digitorum longus musclesoleus muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionstructural constituent of muscle protein binding protein homodimerization activity identical protein binding actin filament binding muscle alpha actinin binding structural molecule activity conferring elasticity kinase bindingCellular componentcytoplasm myosin filament sarcomere striated muscle myosin thick filament Z disc M band striated muscle thin filamentBiological processmuscle contraction extraocular skeletal muscle development striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly positive regulation of gene expression protein kinase A signaling positive regulation of protein secretion skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac myofibril assembly cardiac muscle tissue morphogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez873617929EnsemblENSG00000101605ENSMUSG00000024049UniProtP52179Q62234RefSeq mRNA NM 003803NM 019856NM 001083934NM 010867RefSeq protein NP 003794NP 062830NP 001077403NP 034997Location UCSC Chr 18 3 07 3 22 MbChr 17 71 31 71 43 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Structure 2 Function 3 Clinical Significance 4 Interactions 5 References 6 Further readingStructure editAlternatively spliced variants of MYOM1 including EH myomesin 7 Skelemin 8 and Myomesin 1 8 9 10 have been identified with Skelemin having an additional 96 amino acids rich in serine and proline residues 8 Myomesin 1 like myomesin 2 and titin is a member of a family of myosin associated proteins containing structural modules with strong homology to either fibronectin type III motif I or immunoglobulin C2 motif II domains Myomesin 1 bears uniqueness within this family in that it has intermediate filament core like motifs one near each terminus 11 Myomesin 1 and Myomesin 2 each have a unique N terminal region followed by 12 modules of motif I or motif II in the arrangement II II I I I I I II II II II II The two proteins share 50 sequence identity in this repeat containing region The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band Alternatively spliced tissue specific transcript variants encoding different isoforms have been identified 12 Myomesin 1 can dimerize in an anti parallel fashion via its C terminal region 13 Function editTitin together with its associated proteins interconnects the major structure of sarcomeres the M bands and Z discs The C terminal end of the titin string extends into the M line where it binds tightly to Myomesin 1 and myomesin 2 Skelemin Myomesin 1 is concentrated at peripheral regions of M bands and is postulated to link myofibrils with the intermediate filament cytoskeleton 11 Skelemin Myomesin 1 has been detected in the nucleus as well as the cytoskeletal suggesting that it may play a role in gene expression 14 Myomesin 1 functions to mediate stretch induced signaling 15 and the EH myomesin splice variant expressed in embryonic hearts and in dilated cardiomyopathy can modulate its elasticity 16 Clinical Significance editThe fetal EH myomesin alternatively spliced form of MYOM1 has been shown to be reexpressed at an early timepoint in the progression of dilated cardiomyopathy coincident with isoform switches in titin 17 MYOM1 has also been shown to be abnormally spliced in patients with myotonic dystrophy type I specifically exon 17a 18 Interactions editSkelemin Myomesin 1 has been shown to interact with ITGB1 19 ITGB3 19 20 ITGA2B 20 MYH7 21 22 23 Titin 21 PNKD 24 References edit a b c GRCh38 Ensembl release 89 ENSG00000101605 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024049 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Speel EJ van der Ven PF Albrechts JC Ramaekers FC Furst DO Hopman AH Nov 1998 Assignment of the human gene for the sarcomeric M band protein myomesin MYOM1 to 18p11 31 p11 32 Genomics 54 1 184 6 doi 10 1006 geno 1998 5503 PMID 9806852 Entrez Gene MYOM1 myomesin 1 skelemin 185kDa Agarkova I Auerbach D Ehler E Perriard JC Apr 2000 A novel marker for vertebrate embryonic heart the EH myomesin isoform The Journal of Biological Chemistry 275 14 10256 64 doi 10 1074 jbc 275 14 10256 PMID 10744711 a b c Steiner F Weber K Furst DO Feb 1999 M band proteins myomesin and skelemin are encoded by the same gene analysis of its organization and expression Genomics 56 1 78 89 doi 10 1006 geno 1998 5682 PMID 10036188 Protein sequence of human MYOM1 Uniprot ID P52179 Cardiac Organellar Protein Atlas Knowledgebase COPaKB Archived from the original on 24 June 2015 Retrieved 24 June 2015 Protein sequence of human MYOM1 Uniprot ID P52179 2 Cardiac Organellar Protein Atlas Knowledgebase COPaKB Archived from the original on 24 June 2015 Retrieved 24 June 2015 a b Price MG Gomer RH Oct 1993 Skelemin a cytoskeletal M disc periphery protein contains motifs of adhesion recognition and intermediate filament proteins The Journal of Biological Chemistry 268 29 21800 10 doi 10 1016 S0021 9258 20 80613 9 PMID 8408035 Bantle S Keller S Haussmann I Auerbach D Perriard E Muhlebach S Perriard JC Aug 1996 Tissue specific isoforms of chicken myomesin are generated by alternative splicing The Journal of Biological Chemistry 271 32 19042 52 doi 10 1074 jbc 271 32 19042 PMID 8702575 Lange S Himmel M Auerbach D Agarkova I Hayess K Furst DO Perriard JC Ehler E Jan 2005 Dimerisation of myomesin implications for the structure of the sarcomeric M band Journal of Molecular Biology 345 2 289 98 doi 10 1016 j jmb 2004 10 040 PMID 15571722 Reddy KB Fox JE Price MG Kulkarni S Gupta S Das B Smith DM 2008 Nuclear localization of Myomesin 1 possible functions Journal of Muscle Research and Cell Motility 29 1 1 8 doi 10 1007 s10974 008 9137 x PMID 18521710 S2CID 12298270 Agarkova I Perriard JC Sep 2005 The M band an elastic web that crosslinks thick filaments in the center of the sarcomere Trends in Cell Biology 15 9 477 85 CiteSeerX 10 1 1 384 2007 doi 10 1016 j tcb 2005 07 001 PMID 16061384 Schoenauer R Bertoncini P Machaidze G Aebi U Perriard JC Hegner M Agarkova I Jun 2005 Myomesin is a molecular spring with adaptable elasticity Journal of Molecular Biology 349 2 367 79 doi 10 1016 j jmb 2005 03 055 PMID 15890201 Schoenauer R Emmert MY Felley A Ehler E Brokopp C Weber B Nemir M Faggian GG Pedrazzini T Falk V Hoerstrup SP Agarkova I Mar 2011 EH myomesin splice isoform is a novel marker for dilated cardiomyopathy Basic Research in Cardiology 106 2 233 47 doi 10 1007 s00395 010 0131 2 PMC 3032906 PMID 21069531 Koebis M Ohsawa N Kino Y Sasagawa N Nishino I Ishiura S Sep 2011 Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1 Genes to Cells 16 9 961 72 doi 10 1111 j 1365 2443 2011 01542 x PMID 21794030 S2CID 3272510 a b Reddy KB Gascard P Price MG Negrescu EV Fox JE Dec 1998 Identification of an interaction between the m band protein skelemin and beta integrin subunits Colocalization of a skelemin like protein with beta1 and beta3 integrins in non muscle cells The Journal of Biological Chemistry 273 52 35039 47 doi 10 1074 jbc 273 52 35039 PMID 9857037 a b Deshmukh L Tyukhtenko S Liu J Fox JE Qin J Vinogradova O Nov 2007 Structural insight into the interaction between platelet integrin alphaIIbbeta3 and cytoskeletal protein skelemin The Journal of Biological Chemistry 282 44 32349 56 doi 10 1074 jbc M704666200 PMID 17804417 a b Obermann WM Gautel M Weber K Furst DO Jan 1997 Molecular structure of the sarcomeric M band mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin The EMBO Journal 16 2 211 20 doi 10 1093 emboj 16 2 211 PMC 1169628 PMID 9029142 Obermann WM van der Ven PF Steiner F Weber K Furst DO Apr 1998 Mapping of a myosin binding domain and a regulatory phosphorylation site in M protein a structural protein of the sarcomeric M band Molecular Biology of the Cell 9 4 829 40 doi 10 1091 mbc 9 4 829 PMC 25310 PMID 9529381 Auerbach D Bantle S Keller S Hinderling V Leu M Ehler E Perriard JC May 1999 Different domains of the M band protein myomesin are involved in myosin binding and M band targeting Molecular Biology of the Cell 10 5 1297 308 doi 10 1091 mbc 10 5 1297 PMC 25262 PMID 10233145 Li TB Liu XH Feng S Hu Y Yang WX Han Y Wang YG Gong LM Jun 2004 Characterization of MR 1 a novel myofibrillogenesis regulator in human muscle PDF Acta Biochimica et Biophysica Sinica 36 6 412 8 doi 10 1093 abbs 36 6 412 PMID 15188056 S2CID 18331104 Archived from the original PDF on 2019 02 22 Further reading editGrove BK Kurer V Lehner C Doetschman TC Perriard JC Eppenberger HM Feb 1984 A new 185 000 dalton skeletal muscle protein detected by monoclonal antibodies The Journal of Cell Biology 98 2 518 24 doi 10 1083 jcb 98 2 518 PMC 2113097 PMID 6537951 Vinkemeier U Obermann W Weber K Furst DO Sep 1993 The globular head domain of titin extends into the center of the sarcomeric M band cDNA cloning epitope mapping and immunoelectron microscopy of two titin associated proteins Journal of Cell Science 106 1 319 30 doi 10 1242 jcs 106 1 319 PMID 7505783 Obermann WM Plessmann U Weber K Furst DO Oct 1995 Purification and biochemical characterization of myomesin a myosin binding and titin binding protein from bovine skeletal muscle European Journal of Biochemistry 233 1 110 5 doi 10 1111 j 1432 1033 1995 110 1 x PMID 7588733 Steiner F Weber K Furst DO Feb 1999 M band proteins myomesin and skelemin are encoded by the same gene analysis of its organization and expression Genomics 56 1 78 89 doi 10 1006 geno 1998 5682 PMID 10036188 Agarkova I Auerbach D Ehler E Perriard JC Apr 2000 A novel marker for vertebrate embryonic heart the EH myomesin isoform The Journal of Biological Chemistry 275 14 10256 64 doi 10 1074 jbc 275 14 10256 PMID 10744711 Porter JD Merriam AP Gong B Kasturi S Zhou X Hauser KF Andrade FH Cheng G Sep 2003 Postnatal suppression of myomesin muscle creatine kinase and the M line in rat extraocular muscle The Journal of Experimental Biology 206 Pt 17 3101 12 doi 10 1242 jeb 00511 PMID 12878677 S2CID 21867785 Hornemann T Kempa S Himmel M Hayess K Furst DO Wallimann T Sep 2003 Muscle type creatine kinase interacts with central domains of the M band proteins myomesin and M protein Journal of Molecular Biology 332 4 877 87 doi 10 1016 S0022 2836 03 00921 5 PMID 12972258 Lange S Himmel M Auerbach D Agarkova I Hayess K Furst DO Perriard JC Ehler E Jan 2005 Dimerisation of myomesin implications for the structure of the sarcomeric M band Journal of Molecular Biology 345 2 289 98 doi 10 1016 j jmb 2004 10 040 PMID 15571722 Schoenauer R Bertoncini P Machaidze G Aebi U Perriard JC Hegner M Agarkova I Jun 2005 Myomesin is a molecular spring with adaptable elasticity Journal of Molecular Biology 349 2 367 79 doi 10 1016 j jmb 2005 03 055 PMID 15890201 Retrieved from https en wikipedia org w index php title MYOM1 amp oldid 1212949242, wikipedia, wiki, book, books, library,

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