Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,[2] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.[3][4][5]
Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Torkar M, Haude A, Milne S, Beck S, Trowsdale J, Wilson MJ (December 2000). "Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion". European Journal of Immunology. 30 (12): 3655–62. doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y. PMID 11169408. S2CID 38450831.
^Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324. S2CID 45021877.
^Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455. S2CID 36907307.
^"Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3".
^Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (March 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". Journal of Immunology. 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.
Further readingedit
Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC2196312. PMID 9151699.
Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (December 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC2199153. PMID 9382880.
Wiśniewski A, Łuszczek W, Mańczak M, Jasek M, Kubicka W, Cislo M, Kuśnierczyk P (April 2003). "Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls". Human Immunology. 64 (4): 458–61. doi:10.1016/S0198-8859(03)00025-9. PMID 12651072.
Norman PJ, Carey BS, Stephens HA, Vaughan RW (June 2003). "DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3". Immunogenetics. 55 (3): 165–71. doi:10.1007/s00251-003-0561-1. PMID 12750859. S2CID 52863887.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Overview of all the structural information available in the PDB for UniProt: Q8N6C8 (Leukocyte immunoglobulin-like receptor subfamily A member 3) at the PDBe-KB.
lilra3, leukocyte, immunoglobulin, like, receptor, subfamily, member, lilr, also, known, cd85, antigen, like, family, member, cd85e, immunoglobulin, like, transcript, leukocyte, immunoglobulin, like, receptor, protein, that, humans, encoded, gene, located, wit. Leukocyte immunoglobulin like receptor subfamily A member 3 LILR A3 also known as CD85 antigen like family member E CD85e immunoglobulin like transcript 6 ILT 6 and leukocyte immunoglobulin like receptor 4 LIR 4 is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13 4 Unlike many of its family LILRA3 lacks a transmembrane domain The function of LILRA3 is currently unknown however it is highly homologous to other LILR genes 2 and can bind human leukocyte antigen HLA class I Therefore if secreted the LILRA3 might impair interactions of membrane bound LILRs such as LILRB1 an inhibitory receptor expressed on effector and memory CD8 T cells with their HLA ligands thus modulating immune reactions and influencing susceptibility to disease 3 4 5 LILRA3Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes3Q2CIdentifiersAliasesLILRA3 CD85E HM31 HM43 ILT 6 ILT6 LIR 4 LIR4 leukocyte immunoglobulin like receptor A3External IDsOMIM 604818 GeneCards LILRA3RNA expression patternBgeeHumanMouse ortholog n an aBioGPSMore reference expression dataGene ontologyMolecular functionantigen binding signaling receptor activityCellular componentextracellular region plasma membrane specific granule membrane tertiary granule membrane ficolin 1 rich granule membraneBiological processdefense response adaptive immune response signal transduction immune system process neutrophil degranulationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez11026n aEnsembln an aUniProtQ8N6C8n aRefSeq mRNA NM 001172654NM 006865n aRefSeq protein NP 001166125NP 006856n aLocation UCSC n an aPubMed search 1 n aWikidataView Edit Human Like the closely related LILRA1 LILRA3 binds to both normal and unfolded free heavy chains of HLA class I with a preference for free heavy chains of HLA C alleles 6 Contents 1 See also 2 References 3 Further reading 4 External linksSee also editCluster of differentiationReferences edit Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Torkar M Haude A Milne S Beck S Trowsdale J Wilson MJ December 2000 Arrangement of the ILT gene cluster a common null allele of the ILT6 gene results from a 6 7 kbp deletion European Journal of Immunology 30 12 3655 62 doi 10 1002 1521 4141 200012 30 12 lt 3655 aid immu3655 gt 3 0 co 2 y PMID 11169408 S2CID 38450831 Arm JP Nwankwo C Austen KF September 1997 Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor Journal of Immunology 159 5 2342 9 doi 10 4049 jimmunol 159 5 2342 PMID 9278324 S2CID 45021877 Borges L Hsu ML Fanger N Kubin M Cosman D December 1997 A family of human lymphoid and myeloid Ig like receptors some of which bind to MHC class I molecules Journal of Immunology 159 11 5192 6 doi 10 4049 jimmunol 159 11 5192 PMID 9548455 S2CID 36907307 Entrez Gene LILRA3 leukocyte immunoglobulin like receptor subfamily A without TM domain member 3 Jones DC Kosmoliaptsis V Apps R Lapaque N Smith I Kono A Chang C Boyle LH Taylor CJ Trowsdale J Allen RL March 2011 HLA class I allelic sequence and conformation regulate leukocyte Ig like receptor binding Journal of Immunology 186 5 2990 7 doi 10 4049 jimmunol 1003078 PMID 21270408 Further reading editSamaridis J Colonna M March 1997 Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells structural evidence for new stimulatory and inhibitory pathways European Journal of Immunology 27 3 660 5 doi 10 1002 eji 1830270313 PMID 9079806 S2CID 2212182 Cella M Dohring C Samaridis J Dessing M Brockhaus M Lanzavecchia A Colonna M May 1997 A novel inhibitory receptor ILT3 expressed on monocytes macrophages and dendritic cells involved in antigen processing The Journal of Experimental Medicine 185 10 1743 51 doi 10 1084 jem 185 10 1743 PMC 2196312 PMID 9151699 Colonna M Navarro F Bellon T Llano M Garcia P Samaridis J Angman L Cella M Lopez Botet M December 1997 A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells The Journal of Experimental Medicine 186 11 1809 18 doi 10 1084 jem 186 11 1809 PMC 2199153 PMID 9382880 Wisniewski A Luszczek W Manczak M Jasek M Kubicka W Cislo M Kusnierczyk P April 2003 Distribution of LILRA3 ILT6 LIR4 deletion in psoriatic patients and healthy controls Human Immunology 64 4 458 61 doi 10 1016 S0198 8859 03 00025 9 PMID 12651072 Norman PJ Carey BS Stephens HA Vaughan RW June 2003 DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin like receptor LILRA3 Immunogenetics 55 3 165 71 doi 10 1007 s00251 003 0561 1 PMID 12750859 S2CID 52863887 Zhang Z Henzel WJ October 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Science 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 External links editLILRA3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Overview of all the structural information available in the PDB for UniProt Q8N6C8 Leukocyte immunoglobulin like receptor subfamily A member 3 at the PDBe KB This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This immunology article is a stub You can help Wikipedia by expanding it vte nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LILRA3 amp oldid 1193910508, wikipedia, wiki, book, books, library,
