Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.
The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.[6]Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000115590 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026073 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
^Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.
^"Entrez Gene: IL1R2 interleukin 1 receptor, type II".
Further readingedit
McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI (Oct 1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC452992. PMID 1833184.
Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP (Oct 1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry. 266 (30): 20311–5. doi:10.1016/S0021-9258(18)54924-3. PMID 1834644.
Fasano MB, Cousart S, Neal S, McCall CE (Nov 1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation. 88 (5): 1452–9. doi:10.1172/JCI115454. PMC295647. PMID 1834697.
Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J (Sep 1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation. 73 (3): 347–55. PMID 7564267.
Symons JA, Young PR, Duff GW (Feb 1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1714–8. Bibcode:1995PNAS...92.1714S. doi:10.1073/pnas.92.5.1714. PMC42590. PMID 7878046.
Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, Giri JG, Dower SK (Nov 1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology. 153 (10): 4766–74. doi:10.4049/jimmunol.153.10.4766. PMID 7963543. S2CID 23226920.
Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE (Dec 1994). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802–9. doi:10.4049/jimmunol.153.12.5802. PMID 7989776. S2CID 20750506.
Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, Mantovani A, Colotta F (Feb 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMC2191363. PMID 8294881.
Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A (Jul 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
Sambo P, Fadlon EJ, Sironi M, Matteucci C, Introna M, Mantovani A, Colotta F (Mar 1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood. 87 (5): 1682–6. doi:10.1182/blood.V87.5.1682.bloodjournal8751682. PMID 8634411.
Larregina A, Morelli A, Kolkowski E, Fainboim L (Feb 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology. 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMC1384291. PMID 8698397.
Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, De Souza EB (Aug 1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856.
Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M, Mantovani A (Apr 1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology. 156 (7): 2534–41. doi:10.4049/jimmunol.156.7.2534. PMID 8786316. S2CID 7669945.
Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (Aug 1996). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439.
Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Nov 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (Jan 1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases. 175 (1): 118–22. doi:10.1093/infdis/175.1.118. PMID 8985204.
Rauschmayr T, Groves RW, Kupper TS (May 1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America. 94 (11): 5814–9. Bibcode:1997PNAS...94.5814R. doi:10.1073/pnas.94.11.5814. PMC20863. PMID 9159157.
Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, Jégou B (Jun 1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
Cannon JG, Angel JB, Abad LW, Vannier E, Mileno MD, Fagioli L, Wolff SM, Komaroff AL (May 1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406. S2CID 13013291.
Fink GW, Norman JG (Dec 1997). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine. 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814.
interleukin, receptor, type, also, known, cd121b, cluster, differentiation, 121b, interleukin, receptor, il1r2, also, denotes, human, gene, il1r2available, structurespdbortholog, search, pdbe, rcsblist, codes3o4oidentifiersaliasesil1r2, cd121b, cdw121b, 1rt2, . Interleukin 1 receptor type II IL 1R2 also known as CD121b Cluster of Differentiation 121b is an interleukin receptor IL1R2 also denotes its human gene IL1R2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3O4OIdentifiersAliasesIL1R2 CD121b CDw121b IL 1R 2 IL 1RT 2 IL 1RT2 IL1R2c IL1RB Interleukin 1 receptor type II interleukin 1 receptor type 2External IDsOMIM 147811 MGI 96546 HomoloGene 7783 GeneCards IL1R2Gene location Human Chr Chromosome 2 human 1 Band2q11 2Start101 991 960 bp 1 End102 028 544 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 B 1 18 65 cMStart40 113 239 bp 2 End40 164 391 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus epididymisbloodright lunghuman peniscavity of mouthvulvaperiodontal fiberspleenrectumnippleTop expressed inesophaguslipskin of backsubcutaneous adipose tissueskin of abdomencervixbloodsecondary oocytebelly cordbone marrowMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioninterleukin 1 type II blocking receptor activity protein binding interleukin 1 receptor activity interleukin 1 bindingCellular componentintegral component of membrane extracellular region plasma membrane membrane cytoplasmBiological processimmune response negative regulation of protein processing negative regulation of cytokine production involved in inflammatory response negative regulation of interleukin 1 mediated signaling pathway cytokine mediated signaling pathway interleukin 1 mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez785016178EnsemblENSG00000115590ENSMUSG00000026073UniProtP27930P27931RefSeq mRNA NM 001261419NM 004633NM 173343NM 010555NM 001360800NM 001360801RefSeq protein NP 001248348NP 004624NP 034685NP 001347729NP 001347730Location UCSC Chr 2 101 99 102 03 MbChr 1 40 11 40 16 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction editThe protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin 1 receptor family This protein binds interleukin 1a IL1A interleukin 1b IL1B and interleukin 1 receptor antagonist IL1Ra preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling IL 1R2 protein also interacts non productively with the second component of the signaling IL 1 receptor namely IL 1RAcP 5 and a complex of the IL 1R2 and IL 1RAcP extracellular domains with interleukin 1 beta has been solved by X ray crystallography 6 Interleukin 4 IL4 is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12 Two alternatively spliced transcript variants encoding the same protein have been reported 7 See also editCluster of differentiation Interleukin 1 receptor type IReferences edit a b c GRCh38 Ensembl release 89 ENSG00000115590 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026073 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lang D Knop J Wesche H Raffetseder U Kurrie R Boraschi D Martin MU 1998 The type II IL 1 receptor interacts with the IL 1 receptor accessory protein a novel mechanism of regulation of IL 1 responsiveness Journal of Immunology 161 12 6871 6877 doi 10 4049 jimmunol 161 12 6871 PMID 9862719 S2CID 8940186 Wang Dongli Zhang Senyan Li Liang Liu Xi Mei Kunrong Wang Xinquan 29 August 2010 Structural insights into the assembly and activation of IL 1b with its receptors Nature Immunology 11 10 905 911 doi 10 1038 ni 1925 PMID 20802483 S2CID 20315956 Entrez Gene IL1R2 interleukin 1 receptor type II Further reading editMcMahan CJ Slack JL Mosley B Cosman D Lupton SD Brunton LL Grubin CE Wignall JM Jenkins NA Brannan CI Oct 1991 A novel IL 1 receptor cloned from B cells by mammalian expression is expressed in many cell types The EMBO Journal 10 10 2821 32 doi 10 1002 j 1460 2075 1991 tb07831 x PMC 452992 PMID 1833184 Dripps DJ Verderber E Ng RK Thompson RC Eisenberg SP Oct 1991 Interleukin 1 receptor antagonist binds to the type II interleukin 1 receptor on B cells and neutrophils The Journal of Biological Chemistry 266 30 20311 5 doi 10 1016 S0021 9258 18 54924 3 PMID 1834644 Fasano MB Cousart S Neal S McCall CE Nov 1991 Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome The Journal of Clinical Investigation 88 5 1452 9 doi 10 1172 JCI115454 PMC 295647 PMID 1834697 Sadouk MB Pelletier JP Tardif G Kiansa K Cloutier JM Martel Pelletier J Sep 1995 Human synovial fibroblasts coexpress IL 1 receptor type I and type II mRNA The increased level of the IL 1 receptor in osteoarthritic cells is related to an increased level of the type I receptor Laboratory Investigation 73 3 347 55 PMID 7564267 Symons JA Young PR Duff GW Feb 1995 Soluble type II interleukin 1 IL 1 receptor binds and blocks processing of IL 1 beta precursor and loses affinity for IL 1 receptor antagonist Proceedings of the National Academy of Sciences of the United States of America 92 5 1714 8 Bibcode 1995PNAS 92 1714S doi 10 1073 pnas 92 5 1714 PMC 42590 PMID 7878046 Arend WP Malyak M Smith MF Whisenand TD Slack JL Sims JE Giri JG Dower SK Nov 1994 Binding of IL 1 alpha IL 1 beta and IL 1 receptor antagonist by soluble IL 1 receptors and levels of soluble IL 1 receptors in synovial fluids Journal of Immunology 153 10 4766 74 doi 10 4049 jimmunol 153 10 4766 PMID 7963543 S2CID 23226920 Giri JG Wells J Dower SK McCall CE Guzman RN Slack J Bird TA Shanebeck K Grabstein KH Sims JE Dec 1994 Elevated levels of shed type II IL 1 receptor in sepsis Potential role for type II receptor in regulation of IL 1 responses Journal of Immunology 153 12 5802 9 doi 10 4049 jimmunol 153 12 5802 PMID 7989776 S2CID 20750506 Re F Muzio M De Rossi M Polentarutti N Giri JG Mantovani A Colotta F Feb 1994 The type II receptor as a decoy target for interleukin 1 in polymorphonuclear leukocytes characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor The Journal of Experimental Medicine 179 2 739 43 doi 10 1084 jem 179 2 739 PMC 2191363 PMID 8294881 Colotta F Re F Muzio M Bertini R Polentarutti N Sironi M Giri JG Dower SK Sims JE Mantovani A Jul 1993 Interleukin 1 type II receptor a decoy target for IL 1 that is regulated by IL 4 Science 261 5120 472 5 Bibcode 1993Sci 261 472C doi 10 1126 science 8332913 PMID 8332913 Sambo P Fadlon EJ Sironi M Matteucci C Introna M Mantovani A Colotta F Mar 1996 Reactive oxygen intermediates cause rapid release of the interleukin 1 decoy receptor from human myelomonocytic cells Blood 87 5 1682 6 doi 10 1182 blood V87 5 1682 bloodjournal8751682 PMID 8634411 Larregina A Morelli A Kolkowski E Fainboim L Feb 1996 Flow cytometric analysis of cytokine receptors on human Langerhans cells Changes observed after short term culture Immunology 87 2 317 25 doi 10 1046 j 1365 2567 1996 451513 x PMC 1384291 PMID 8698397 Liu C Hart RP Liu XJ Clevenger W Maki RA De Souza EB Aug 1996 Cloning and characterization of an alternatively processed human type II interleukin 1 receptor mRNA The Journal of Biological Chemistry 271 34 20965 72 doi 10 1074 jbc 271 34 20965 PMID 8702856 Colotta F Saccani S Giri JG Dower SK Sims JE Introna M Mantovani A Apr 1996 Regulated expression and release of the IL 1 decoy receptor in human mononuclear phagocytes Journal of Immunology 156 7 2534 41 doi 10 4049 jimmunol 156 7 2534 PMID 8786316 S2CID 7669945 Sebire G Delfraissy JF Demotes Mainard J Oteifeh A Emilie D Tardieu M Aug 1996 Interleukin 13 and interleukin 4 act as interleukin 6 inducers in human microglial cells Cytokine 8 8 636 41 doi 10 1006 cyto 1996 0085 PMID 8894439 Lovenberg TW Crowe PD Liu C Chalmers DT Liu XJ Liaw C Clevenger W Oltersdorf T De Souza EB Maki RA Nov 1996 Cloning of a cDNA encoding a novel interleukin 1 receptor related protein IL 1R rp2 Journal of Neuroimmunology 70 2 113 22 doi 10 1016 S0165 5728 96 00047 1 PMID 8898719 S2CID 53171191 van der Poll T de Waal Malefyt R Coyle SM Lowry SF Jan 1997 Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia sequential measurements of plasma soluble interleukin IL 1 receptor type II IL 10 and IL 13 The Journal of Infectious Diseases 175 1 118 22 doi 10 1093 infdis 175 1 118 PMID 8985204 Rauschmayr T Groves RW Kupper TS May 1997 Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1 mediated inflammation Proceedings of the National Academy of Sciences of the United States of America 94 11 5814 9 Bibcode 1997PNAS 94 5814R doi 10 1073 pnas 94 11 5814 PMC 20863 PMID 9159157 Gomez E Morel G Cavalier A Lienard MO Haour F Courtens JL Jegou B Jun 1997 Type I and type II interleukin 1 receptor expression in rat mouse and human testes Biology of Reproduction 56 6 1513 26 doi 10 1095 biolreprod56 6 1513 PMID 9166705 Cannon JG Angel JB Abad LW Vannier E Mileno MD Fagioli L Wolff SM Komaroff AL May 1997 Interleukin 1 beta interleukin 1 receptor antagonist and soluble interleukin 1 receptor type II secretion in chronic fatigue syndrome Journal of Clinical Immunology 17 3 253 61 doi 10 1023 A 1027314713231 PMID 9168406 S2CID 13013291 Fink GW Norman JG Dec 1997 Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis Cytokine 9 12 1023 7 doi 10 1006 cyto 1997 0260 PMID 9417814 External links editIL1R2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine 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