Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (June 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
^Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. Bibcode:1995Sci...268..405C. doi:10.1126/science.7716543. PMID 7716543.
^ ab"Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".
^Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A.99 (25): 16180–5. Bibcode:2002PNAS...9916180B. doi:10.1073/pnas.212643199. PMC138585. PMID 12454284.
^Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (December 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
^Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
^Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700. S2CID 24707532.
Further readingedit
Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC (1997). "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors". Nature. 389 (6646): 96–100. Bibcode:1997Natur.389...96F. doi:10.1038/38028. PMID 9288975. S2CID 4365964.
Kim J, Chwae YJ, Kim MY, Choi IH, Park JH, Kim SJ (1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875–82. PMID 9378975.
Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors". Immunity. 7 (6): 739–51. doi:10.1016/S1074-7613(00)80393-3. PMID 9430220.
Rajagopalan S, Long EO (1998). "Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells". J. Immunol. 161 (3): 1299–305. PMID 9686591.
Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
Shilling HG, Lienert-Weidenbach K, Valiante NM, Uhrberg M, Parham P (1998). "Evidence for recombination as a mechanism for KIR diversification". Immunogenetics. 48 (6): 413–6. doi:10.1007/s002510050453. PMID 9799338. S2CID 11887627.
Chwae YJ, Cho SE, Kim SJ, Kim J (1999). "Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual". Immunol. Lett. 68 (2–3): 267–74. doi:10.1016/S0165-2478(99)00062-0. PMID 10424431.
Fan QR, Wiley DC (1999). "Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor". J. Exp. Med. 190 (1): 113–23. doi:10.1084/jem.190.1.113. PMC2195553. PMID 10429675.
Richardson J, Reyburn HT, Luque I, Valés-Gómez M, Strominger JL (2000). "Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site". Eur. J. Immunol. 30 (5): 1480–5. doi:10.1002/(SICI)1521-4141(200005)30:5<1480::AID-IMMU1480>3.0.CO;2-7. PMID 10820396.
Fan QR, Long EO, Wiley DC (2000). "A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer". Eur. J. Immunol. 30 (9): 2692–7. doi:10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0. PMID 11009104.
Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (2001). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens. 57 (1): 22–31. doi:10.1034/j.1399-0039.2001.057001022.x. PMID 11169255.
Fan QR, Long EO, Wiley DC (2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700. S2CID 24707532.
Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard A (2002). "Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction". Blood. 100 (8): 2874–81. doi:10.1182/blood-2002-02-0643. PMID 12351398.
Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A (2003). "Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction". Blood. 100 (12): 4098–107. doi:10.1182/blood-2002-04-1284. PMID 12393468.
Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (2003). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. Bibcode:2002PNAS...9916180B. doi:10.1073/pnas.212643199. PMC138585. PMID 12454284.
kir2dl1, killer, cell, immunoglobulin, like, receptor, 2dl1, protein, that, humans, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1im9, 1nkridentifiersaliases, cd158a, kir221, nkat, nkat, nkat1, killer, cell, immunoglobuli. Killer cell immunoglobulin like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene 3 4 5 KIR2DL1Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1IM9 1NKRIdentifiersAliasesKIR2DL1 CD158A KIR K64 KIR221 NKAT NKAT 1 NKAT1 p58 1 killer cell immunoglobulin like receptor two Ig domains and long cytoplasmic tail 1 KIR2DS1 KIR2DL3External IDsOMIM 604936 HomoloGene 130667 GeneCards KIR2DL1Gene location Human Chr Chromosome 19 human 1 Band19q13 42Start54 769 793 bp 1 End54 784 322 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inbloodspleenright lungupper lobe of left lungbone marrowendometriummonocyteplacentaright lobe of liversubcutaneous adipose tissuen aMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding signaling receptor activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membraneBiological processnatural killer cell inhibitory signaling pathway immune response regulation of immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3802n aEnsemblENSG00000278821ENSG00000275196ENSG00000278805ENSG00000125498ENSG00000284401ENSG00000278755ENSG00000278495ENSG00000278738ENSG00000278248ENSG00000278503ENSG00000284530ENSG00000276820ENSG00000275080ENSG00000275276ENSG00000273794ENSG00000276625ENSG00000277616ENSG00000284100ENSG00000284514ENSG00000283723ENSG00000274926ENSG00000278207ENSG00000274782ENSG00000284347ENSG00000273510ENSG00000274692ENSG00000277833ENSG00000276310ENSG00000284551ENSG00000275750ENSG00000275522ENSG00000277356ENSG00000284145n aUniProtP43626n aRefSeq mRNA NM 014218n aRefSeq protein NP 055033n aLocation UCSC Chr 19 54 77 54 78 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Function 2 Interactions 3 See also 4 References 5 Further readingFunction editKiller cell immunoglobulin like receptors KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13 4 within the 1 Mb leukocyte receptor complex LRC The gene content of the KIR gene cluster varies among haplotypes although several framework genes are found in all haplotypes KIR3DL3 KIR3DP1 KIR2DL4 KIR3DL2 The KIR proteins are classified by the number of extracellular immunoglobulin domains 2D or 3D and by whether they have a long L or short S cytoplasmic domain KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine based inhibitory motif ITIM while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals The ligands for several KIR proteins are subsets of HLA class I molecules thus KIR proteins are thought to play an important role in regulation of the immune response 5 Interactions editKIR2DL1 has been shown to interact with HLA C 6 7 8 9 See also editCluster of differentiationReferences edit a b c ENSG00000275196 ENSG00000278805 ENSG00000125498 ENSG00000284401 ENSG00000278755 ENSG00000278495 ENSG00000278738 ENSG00000278248 ENSG00000278503 ENSG00000284530 ENSG00000276820 ENSG00000275080 ENSG00000275276 ENSG00000273794 ENSG00000276625 ENSG00000277616 ENSG00000284100 ENSG00000284514 ENSG00000283723 ENSG00000274926 ENSG00000278207 ENSG00000274782 ENSG00000284347 ENSG00000273510 ENSG00000274692 ENSG00000277833 ENSG00000276310 ENSG00000284551 ENSG00000275750 ENSG00000275522 ENSG00000277356 ENSG00000284145 GRCh38 Ensembl release 89 ENSG00000278821 ENSG00000275196 ENSG00000278805 ENSG00000125498 ENSG00000284401 ENSG00000278755 ENSG00000278495 ENSG00000278738 ENSG00000278248 ENSG00000278503 ENSG00000284530 ENSG00000276820 ENSG00000275080 ENSG00000275276 ENSG00000273794 ENSG00000276625 ENSG00000277616 ENSG00000284100 ENSG00000284514 ENSG00000283723 ENSG00000274926 ENSG00000278207 ENSG00000274782 ENSG00000284347 ENSG00000273510 ENSG00000274692 ENSG00000277833 ENSG00000276310 ENSG00000284551 ENSG00000275750 ENSG00000275522 ENSG00000277356 ENSG00000284145 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wagtmann N Biassoni R Cantoni C Verdiani S Malnati MS Vitale M Bottino C Moretta L Moretta A Long EO June 1995 Molecular clones of the p58 NK cell receptor reveal immunoglobulin related molecules with diversity in both the extra and intracellular domains Immunity 2 5 439 49 doi 10 1016 1074 7613 95 90025 X PMID 7749980 Colonna M Samaridis J May 1995 Cloning of immunoglobulin superfamily members associated with HLA C and HLA B recognition by human natural killer cells Science 268 5209 405 8 Bibcode 1995Sci 268 405C doi 10 1126 science 7716543 PMID 7716543 a b Entrez Gene KIR2DL1 killer cell immunoglobulin like receptor two domains long cytoplasmic tail 1 Boyson JE Erskine R Whitman MC Chiu M Lau JM Koopman LA Valter MM Angelisova P Horejsi V Strominger JL December 2002 Disulfide bond mediated dimerization of HLA G on the cell surface Proc Natl Acad Sci U S A 99 25 16180 5 Bibcode 2002PNAS 9916180B doi 10 1073 pnas 212643199 PMC 138585 PMID 12454284 Baba E Erskine R Boyson JE Cohen GB Davis DM Malik P Mandelboim O Reyburn HT Strominger JL December 2000 N linked carbohydrate on human leukocyte antigen C and recognition by natural killer cell inhibitory receptors Hum Immunol 61 12 1202 18 doi 10 1016 S0198 8859 00 00184 1 PMID 11163076 Vales Gomez M Reyburn HT Mandelboim M Strominger JL September 1998 Kinetics of interaction of HLA C ligands with natural killer cell inhibitory receptors Immunity 9 3 337 44 doi 10 1016 S1074 7613 00 80616 0 PMID 9768753 Fan QR Long EO Wiley DC May 2001 Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1 HLA Cw4 complex Nat Immunol 2 5 452 60 doi 10 1038 87766 PMID 11323700 S2CID 24707532 Further reading editFan QR Mosyak L Winter CC Wagtmann N Long EO Wiley DC 1997 Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors Nature 389 6646 96 100 Bibcode 1997Natur 389 96F doi 10 1038 38028 PMID 9288975 S2CID 4365964 Kim J Chwae YJ Kim MY Choi IH Park JH Kim SJ 1997 Molecular basis of HLA C recognition by p58 natural killer cell inhibitory receptors J Immunol 159 8 3875 82 PMID 9378975 Valiante NM Uhrberg M Shilling HG Lienert Weidenbach K Arnett KL D Andrea A Phillips JH Lanier LL Parham P 1998 Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors Immunity 7 6 739 51 doi 10 1016 S1074 7613 00 80393 3 PMID 9430220 Uhrberg M Valiante NM Shum BP Shilling HG Lienert Weidenbach K Corliss B Tyan D Lanier LL Parham P 1998 Human diversity in killer cell inhibitory receptor genes Immunity 7 6 753 63 doi 10 1016 S1074 7613 00 80394 5 PMID 9430221 Rajagopalan S Long EO 1998 Zinc bound to the killer cell inhibitory receptor modulates the negative signal in human NK cells J Immunol 161 3 1299 305 PMID 9686591 Vales Gomez M Reyburn HT Mandelboim M Strominger JL 1998 Kinetics of interaction of HLA C ligands with natural killer cell inhibitory receptors Immunity 9 3 337 44 doi 10 1016 S1074 7613 00 80616 0 PMID 9768753 Shilling HG Lienert Weidenbach K Valiante NM Uhrberg M Parham P 1998 Evidence for recombination as a mechanism for KIR diversification Immunogenetics 48 6 413 6 doi 10 1007 s002510050453 PMID 9799338 S2CID 11887627 Chwae YJ Cho SE Kim SJ Kim J 1999 Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual Immunol Lett 68 2 3 267 74 doi 10 1016 S0165 2478 99 00062 0 PMID 10424431 Fan QR Wiley DC 1999 Structure of human histocompatibility leukocyte antigen HLA Cw4 a ligand for the KIR2D natural killer cell inhibitory receptor J Exp Med 190 1 113 23 doi 10 1084 jem 190 1 113 PMC 2195553 PMID 10429675 Richardson J Reyburn HT Luque I Vales Gomez M Strominger JL 2000 Definition of polymorphic residues on killer Ig like receptor proteins which contribute to the HLA C binding site Eur J Immunol 30 5 1480 5 doi 10 1002 SICI 1521 4141 200005 30 5 lt 1480 AID IMMU1480 gt 3 0 CO 2 7 PMID 10820396 Fan QR Long EO Wiley DC 2000 A disulfide linked natural killer cell receptor dimer has higher affinity for HLA C than wild type monomer Eur J Immunol 30 9 2692 7 doi 10 1002 1521 4141 200009 30 9 lt 2692 AID IMMU2692 gt 3 0 CO 2 0 PMID 11009104 Baba E Erskine R Boyson JE Cohen GB Davis DM Malik P Mandelboim O Reyburn HT Strominger JL 2001 N linked carbohydrate on human leukocyte antigen C and recognition by natural killer cell inhibitory receptors Hum Immunol 61 12 1202 18 doi 10 1016 S0198 8859 00 00184 1 PMID 11163076 Rajalingam R Gardiner CM Canavez F Vilches C Parham P 2001 Identification of seventeen novel KIR variants fourteen of them from two non Caucasian donors Tissue Antigens 57 1 22 31 doi 10 1034 j 1399 0039 2001 057001022 x PMID 11169255 Fan QR Long EO Wiley DC 2001 Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1 HLA Cw4 complex Nat Immunol 2 5 452 60 doi 10 1038 87766 PMID 11323700 S2CID 24707532 Guerra N Michel F Gati A Gaudin C Mishal Z Escudier B Acuto O Chouaib S Caignard A 2002 Engagement of the inhibitory receptor CD158a interrupts TCR signaling preventing dynamic membrane reorganization in CTL tumor cell interaction Blood 100 8 2874 81 doi 10 1182 blood 2002 02 0643 PMID 12351398 Spaggiari GM Contini P Dondero A Carosio R Puppo F Indiveri F Zocchi MR Poggi A 2003 Soluble HLA class I induces NK cell apoptosis upon the engagement of killer activating HLA class I receptors through FasL Fas interaction Blood 100 12 4098 107 doi 10 1182 blood 2002 04 1284 PMID 12393468 Boyson JE Erskine R Whitman MC Chiu M Lau JM Koopman LA Valter MM Angelisova P Horejsi V Strominger JL 2003 Disulfide bond mediated dimerization of HLA G on the cell surface Proc Natl Acad Sci U S A 99 25 16180 5 Bibcode 2002PNAS 9916180B doi 10 1073 pnas 212643199 PMC 138585 PMID 12454284 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte nbsp This immunology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title KIR2DL1 amp oldid 1184207150, wikipedia, wiki, book, books, library,
