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SEMA4D

January 01, 1970

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.[5]

SEMA4D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18
External IDsOMIM: 601866; MGI: 109244; HomoloGene: 21282; GeneCards: SEMA4D; OMA:SEMA4D - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10507

20354

Ensembl

ENSG00000187764

ENSMUSG00000021451

UniProt

Q92854

O09126

RefSeq (mRNA)

NM_001281880
NM_013660

RefSeq (protein)
Location (UCSC)Chr 9: 89.36 – 89.5 MbChr 13: 51.69 – 51.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.[6]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.[7][8]

During skin damage repairs, SEMA4D interacts with Plexin B2 on Gamma delta T cells to play a role in the healing process.[9]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187764 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021451 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".
  6. ^ Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports. 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460.
  7. ^ Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity. 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.
  8. ^ Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.
  9. ^ Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity. 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026. PMC 3430606. PMID 22902232.

Further reading edit

  • Bougeret C, Mansur IG, Dastot H, et al. (1992). "Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation". J. Immunol. 148 (2): 318–23. doi:10.4049/jimmunol.148.2.318. PMID 1530858. S2CID 29224711.
  • Hall KT, Boumsell L, Schultze JL, et al. (1996). "Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11780–5. Bibcode:1996PNAS...9311780H. doi:10.1073/pnas.93.21.11780. PMC 38135. PMID 8876214.
  • Herold C, Elhabazi A, Bismuth G, et al. (1997). "CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion". J. Immunol. 157 (12): 5262–8. doi:10.4049/jimmunol.157.12.5262. PMID 8955171. S2CID 36341775.
  • Furuyama T, Inagaki S, Kosugi A, et al. (1997). "Identification of a novel transmembrane semaphorin expressed on lymphocytes". J. Biol. Chem. 271 (52): 33376–81. doi:10.1074/jbc.271.52.33376. PMID 8969198.
  • Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
  • Elhabazi A, Delaire S, Bensussan A, et al. (2001). "Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis". J. Immunol. 166 (7): 4341–7. doi:10.4049/jimmunol.166.7.4341. PMID 11254687.
  • Delaire S, Billard C, Tordjman R, et al. (2001). "Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration". J. Immunol. 166 (7): 4348–54. doi:10.4049/jimmunol.166.7.4348. PMID 11254688.
  • Vikis HG, Li W, Guan KL (2002). "The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
  • Granziero L, Circosta P, Scielzo C, et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood. 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
  • Love CA, Harlos K, Mavaddat N, et al. (2003). "The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D". Nat. Struct. Biol. 10 (10): 843–8. doi:10.1038/nsb977. PMID 12958590. S2CID 24468463.
  • Giraudon P, Vincent P, Vuaillat C, et al. (2004). "Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells". J. Immunol. 172 (2): 1246–55. doi:10.4049/jimmunol.172.2.1246. PMID 14707103.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Deaglio S, Vaisitti T, Bergui L, et al. (2005). "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival". Blood. 105 (8): 3042–50. doi:10.1182/blood-2004-10-3873. PMID 15613544.
  • Conrotto P, Valdembri D, Corso S, et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood. 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.
  • Basile JR, Afkhami T, Gutkind JS (2005). "Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway". Mol. Cell. Biol. 25 (16): 6889–98. doi:10.1128/MCB.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
  • Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell. Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
  • Nkyimbeng-Takwi EH, Chapoval SP (2011). "Biology and function of neuroimmune semaphorins 4A and 4D". Immunol. Res. 50 (1): 10–21. doi:10.1007/s12026-010-8201-y. PMC 3366695. PMID 21203905.
  • Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2011). "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunol. 12: 30. doi:10.1186/1471-2172-12-30. PMC 3118960. PMID 21595947.
  • Shanks K, Nkyimbeng-Takwi EH, Smith EP, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2013). "Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation". Mol. Immunol. 56 (4): 480–7. doi:10.1016/j.molimm.2013.05.228. PMC 3783523. PMID 23911404.

External links edit


 

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January 01, 1970
sema4d, semaphorin, also, known, cluster, differentiation, cd100, protein, semaphorin, family, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1olz, 3ol2identifiersaliases, c9orf164, cd100, sema, semaj, coll, semapho. Semaphorin 4D SEMA4D also known as Cluster of Differentiation 100 CD100 is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene 5 SEMA4DAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1OLZ 3OL2IdentifiersAliasesSEMA4D C9orf164 CD100 M sema G SEMAJ coll 4 semaphorin 4D COLL4 A8 GR3 BB18External IDsOMIM 601866 MGI 109244 HomoloGene 21282 GeneCards SEMA4D OMA SEMA4D orthologsGene location Human Chr Chromosome 9 human 1 Band9q22 2Start89 360 787 bp 1 End89 498 130 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A5Start51 685 529 bp 2 End51 793 747 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosumbloodmonocyteinferior ganglion of vagus nervelymph nodeinternal globus pallidussubstantia nigraspleengastrocnemius musclesubthalamic nucleusTop expressed inthymuscumulus cellbloodspleensubmandibular glandproximal tubulemolarcorpus callosumcerebellar cortexkidneyMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsignaling receptor binding transmembrane signaling receptor activity protein binding semaphorin receptor binding neuropilin binding identical protein binding signaling receptor activity chemorepellent activityCellular componentintegral component of membrane integral component of plasma membrane membrane plasma membrane extracellular spaceBiological processregulation of dendrite morphogenesis negative regulation of apoptotic process positive regulation of phosphatidylinositol 3 kinase signaling multicellular organism development leukocyte aggregation nervous system development negative regulation of cell adhesion positive regulation of peptidyl tyrosine phosphorylation positive regulation of axonogenesis semaphorin plexin signaling pathway involved in bone trabecula morphogenesis regulation of cell projection organization negative regulation of osteoblast differentiation positive regulation of collateral sprouting regulation of cell shape negative regulation of peptidyl tyrosine phosphorylation cell differentiation positive regulation of protein phosphorylation semaphorin plexin signaling pathway cell adhesion immune response ossification involved in bone maturation positive regulation of cell migration negative regulation of transcription by RNA polymerase II positive regulation of GTPase activity negative regulation of alkaline phosphatase activity negative chemotaxis neural crest cell migration negative regulation of axon extension involved in axon guidance positive regulation of inhibitory synapse assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1050720354EnsemblENSG00000187764ENSMUSG00000021451UniProtQ92854O09126RefSeq mRNA NM 001142287NM 006378NM 182635NM 001371194NM 001371195NM 001371196NM 001371197NM 001371198NM 001371199NM 001371200NM 001371201NM 001371202NM 001281880NM 013660RefSeq protein NP 001135759NP 006369NP 001358123NP 001358124NP 001358125NP 001358126NP 001358127NP 001358128NP 001358129NP 001358130NP 001358131NP 001268809NP 038688NP 001365242NP 001365243NP 001365246NP 001365247NP 001365248NP 001365249NP 001365251NP 001365252NP 001365253NP 001365244NP 001365245NP 001365250NP 001365254Location UCSC Chr 9 89 36 89 5 MbChr 13 51 69 51 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction editSemaphorin 4D Sema 4D is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system By binding plexin B1 receptor it functions as an R Ras GTPase activating protein GAP and repels axon growth cones in both the mature central nervous system 6 In the immune system CD100 binds CD72 to activate B cells and dendritic cells though much about this interaction is still under investigation 7 8 During skin damage repairs SEMA4D interacts with Plexin B2 on Gamma delta T cells to play a role in the healing process 9 See also editCluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000187764 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021451 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene SEMA4D sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D Ito Y Oinuma I Katoh H Kaibuchi K Negishi M July 2006 Sema4D plexin B1 activates GSK 3b through R Ras GAP activity inducing growth cone collapse EMBO Reports 7 7 704 9 doi 10 1038 sj embor 7400737 PMC 1500830 PMID 16799460 Kumanogoh A Watanabe C Lee I Wang X Shi W Araki H Hirata H Iwahori K Uchida J Yasui T Matsumoto M Yoshida K Yakura H Pan C Parnes JR Kikutani H November 2000 Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100 a novel mechanism for regulating B cell signaling Immunity 13 5 621 31 doi 10 1016 S1074 7613 00 00062 5 PMID 11114375 Ishida I Kumanogoh A Suzuki K Akahani S Noda K Kikutani H August 2003 Involvement of CD100 a lymphocyte semaphorin in the activation of the human immune system via CD72 implications for the regulation of immune and inflammatory responses Int Immunol 15 8 1027 34 doi 10 1093 intimm dxg098 PMID 12882840 Deborah A Witherden Megumi Watanabe Olivia Garijo Stephanie E Rieder Gor Sarkisyan Shane J F Cronin Petra Verdino Ian A Wilson Atsushi Kumanogoh Hitoshi Kikutani Luc Teyton Wolfgang H Fischer Wendy L Havran August 2012 The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal gd T Cell Function Immunity 37 2 314 25 doi 10 1016 j immuni 2012 05 026 PMC 3430606 PMID 22902232 Further reading editBougeret C Mansur IG Dastot H et al 1992 Increased surface expression of a newly identified 150 kDa dimer early after human T lymphocyte activation J Immunol 148 2 318 23 doi 10 4049 jimmunol 148 2 318 PMID 1530858 S2CID 29224711 Hall KT Boumsell L Schultze JL et al 1996 Human CD100 a novel leukocyte semaphorin that promotes B cell aggregation and differentiation Proc Natl Acad Sci U S A 93 21 11780 5 Bibcode 1996PNAS 9311780H doi 10 1073 pnas 93 21 11780 PMC 38135 PMID 8876214 Herold C Elhabazi A Bismuth G et al 1997 CD100 is associated with CD45 at the surface of human T lymphocytes Role in T cell homotypic adhesion J Immunol 157 12 5262 8 doi 10 4049 jimmunol 157 12 5262 PMID 8955171 S2CID 36341775 Furuyama T Inagaki S Kosugi A et al 1997 Identification of a novel transmembrane semaphorin expressed on lymphocytes J Biol Chem 271 52 33376 81 doi 10 1074 jbc 271 52 33376 PMID 8969198 Tamagnone L Artigiani S Chen H et al 1999 Plexins are a large family of receptors for transmembrane secreted and GPI anchored semaphorins in vertebrates Cell 99 1 71 80 doi 10 1016 S0092 8674 00 80063 X PMID 10520995 S2CID 17386412 Elhabazi A Delaire S Bensussan A et al 2001 Biological activity of soluble CD100 I The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis J Immunol 166 7 4341 7 doi 10 4049 jimmunol 166 7 4341 PMID 11254687 Delaire S Billard C Tordjman R et al 2001 Biological activity of soluble CD100 II Soluble CD100 similarly to H SemaIII inhibits immune cell migration J Immunol 166 7 4348 54 doi 10 4049 jimmunol 166 7 4348 PMID 11254688 Vikis HG Li W Guan KL 2002 The Plexin B1 Rac interaction inhibits PAK activation and enhances Sema4D ligand binding Genes Dev 16 7 836 45 doi 10 1101 gad 966402 PMC 186329 PMID 11937491 Granziero L Circosta P Scielzo C et al 2003 CD100 Plexin B1 interactions sustain proliferation and survival of normal and leukemic CD5 B lymphocytes Blood 101 5 1962 9 doi 10 1182 blood 2002 05 1339 PMID 12406905 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Izmailova E Bertley FM Huang Q et al 2003 HIV 1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages Nat Med 9 2 191 7 doi 10 1038 nm822 PMID 12539042 S2CID 26145639 Love CA Harlos K Mavaddat N et al 2003 The ligand binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D Nat Struct Biol 10 10 843 8 doi 10 1038 nsb977 PMID 12958590 S2CID 24468463 Giraudon P Vincent P Vuaillat C et al 2004 Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells J Immunol 172 2 1246 55 doi 10 4049 jimmunol 172 2 1246 PMID 14707103 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Deaglio S Vaisitti T Bergui L et al 2005 CD38 and CD100 lead a network of surface receptors relaying positive signals for B CLL growth and survival Blood 105 8 3042 50 doi 10 1182 blood 2004 10 3873 PMID 15613544 Conrotto P Valdembri D Corso S et al 2005 Sema4D induces angiogenesis through Met recruitment by Plexin B1 Blood 105 11 4321 9 doi 10 1182 blood 2004 07 2885 PMID 15632204 Basile JR Afkhami T Gutkind JS 2005 Semaphorin 4D Plexin B1 Induces Endothelial Cell Migration through the Activation of PYK2 Src and the Phosphatidylinositol 3 Kinase Akt Pathway Mol Cell Biol 25 16 6889 98 doi 10 1128 MCB 25 16 6889 6898 2005 PMC 1190270 PMID 16055703 Lewandrowski U Moebius J Walter U Sickmann A 2006 Elucidation of N glycosylation sites on human platelet proteins a glycoproteomic approach Mol Cell Proteomics 5 2 226 33 doi 10 1074 mcp M500324 MCP200 PMID 16263699 Nkyimbeng Takwi EH Chapoval SP 2011 Biology and function of neuroimmune semaphorins 4A and 4D Immunol Res 50 1 10 21 doi 10 1007 s12026 010 8201 y PMC 3366695 PMID 21203905 Smith EP Shanks K Lipsky MM DeTolla LJ Keegan AD Chapoval SP 2011 Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor BMC Immunol 12 30 doi 10 1186 1471 2172 12 30 PMC 3118960 PMID 21595947 Shanks K Nkyimbeng Takwi EH Smith EP Lipsky MM DeTolla LJ Keegan AD Chapoval SP 2013 Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation Mol Immunol 56 4 480 7 doi 10 1016 j molimm 2013 05 228 PMC 3783523 PMID 23911404 External links editSEMA4D protein human at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SEMA4D amp oldid 1191550955, wikipedia, wiki, book, books, library,

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