This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[5]
LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury.[6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease.[7][8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, et al. (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–1751. doi:10.1084/jem.185.10.1743. PMC2196312. PMID 9151699.
^Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–665. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
^ ab"Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
^Mi YJ, Chen H, Guo N, Sun MY, Zhao ZH, Gao XC, et al. (2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging Neuroscience. 9: 199. doi:10.3389/fnagi.2017.00199. PMC5476690. PMID 28676756.
^Lao K, Zhang R, Dai Y, Luan J, Guo N, Xu X, et al. (July 2021). "Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease". Molecular and Cellular Neurosciences. 114: 103630. doi:10.1016/j.mcn.2021.103630. PMID 34029694. S2CID 235203153.
^Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, et al. (September 2013). "Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model". Science. 341 (6152): 1399–1404. Bibcode:2013Sci...341.1399K. doi:10.1126/science.1242077. PMC3853120. PMID 24052308.
^Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (November 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–3434. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
^Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. (April 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology. 160 (7): 3096–3100. doi:10.4049/jimmunol.160.7.3096. PMID 9531263. S2CID 255370078.
Further readingedit
Suciu-Foca N, Cortesini R (July 2007). "Central role of ILT3 in the T suppressor cell cascade". Cellular Immunology. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO (August 1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Current Biology. 7 (8): 615–618. Bibcode:1997CBio....7..615W. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559. S2CID 14484039.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, et al. (December 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–1818. doi:10.1084/jem.186.11.1809. PMC2199153. PMID 9382880.
Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. (April 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology. 160 (7): 3096–3100. doi:10.4049/jimmunol.160.7.3096. PMID 9531263. S2CID 255370078.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–5196. doi:10.4049/jimmunol.159.11.5192. PMID 9548455. S2CID 36907307.
Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (November 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–3434. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, et al. (April 1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells". The Journal of Experimental Medicine. 189 (7): 1149–1156. doi:10.1084/jem.189.7.1149. PMC2193000. PMID 10190906.
Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, et al. (December 2000). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". European Journal of Immunology. 30 (12): 3552–3561. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396. S2CID 42462661.
Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–278. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.
Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature Immunology. 3 (3): 237–243. doi:10.1038/ni760. PMID 11875462. S2CID 35400503.
Willcox BE, Thomas LM, Chapman TL, Heikema AP, West AP, Bjorkman PJ (October 2002). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Structural Biology. 2: 6. doi:10.1186/1472-6807-2-6. PMC130215. PMID 12390682.
Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, et al. (July 2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 8856–8861. Bibcode:2003PNAS..100.8856S. doi:10.1073/pnas.1431057100. PMC166403. PMID 12853576.
Nakajima H, Asai A, Okada A, Ping L, Hamajima F, Sata T, et al. (December 2003). "Transcriptional regulation of ILT family receptors". Journal of Immunology. 171 (12): 6611–6620. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
Papanikolaou NA, Vasilescu ER, Suciu-Foca N (July 2004). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Human Immunology. 65 (7): 700–705. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.
lilrb2, leukocyte, immunoglobulin, like, receptor, subfamily, member, protein, that, humans, encoded, gene, identifiersaliases, ilt4, mir10, lir2, leukocyte, immunoglobulin, like, receptor, cd85dexternal, idsomim, 604815, homologene, 136797, genecards, gene, l. Leukocyte immunoglobulin like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene 3 4 5 LILRB2IdentifiersAliasesLILRB2 ILT4 MIR10 LIR2 MIR 10 LIR 2 leukocyte immunoglobulin like receptor B2 ILT 4 CD85DExternal IDsOMIM 604815 HomoloGene 136797 GeneCards LILRB2Gene location Human Chr Chromosome 19 human 1 Band19q13 42Start54 273 812 bp 1 End54 281 184 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodspleenappendixbone marrowbone marrow cellsright lungupper lobe of left lungright coronary arterygallbladdern aMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez10288n aEnsemblENSG00000274513ENSG00000275463ENSG00000131042ENSG00000276146ENSG00000277751n an aUniProtA2IXV5n aRefSeq mRNA NM 001080978NM 001278403NM 001278404NM 001278405NM 001278406NM 005874n aRefSeq protein NP 001074447NP 001265332NP 001265333NP 001265334NP 001265335NP 005865n aLocation UCSC Chr 19 54 27 54 28 Mbn aPubMed search 2 n aWikidataView Edit HumanThis gene is a member of the leukocyte immunoglobulin like receptor LIR family which is found in a gene cluster at chromosomal region 19q13 4 The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains a transmembrane domain and two to four cytoplasmic immunoreceptor tyrosine based inhibitory motifs ITIMs The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen presenting cells and transduces a negative signal that inhibits stimulation of an immune response It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity Multiple transcript variants encoding different isoforms have been found for this gene 5 LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury 6 However recent studies demonstrate that LILRB2 is a b Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer s disease 7 8 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editLILRB2 has been shown to interact with PTPN6 9 10 See also editCluster of differentiationReferences edit a b c ENSG00000275463 ENSG00000131042 ENSG00000276146 ENSG00000277751 GRCh38 Ensembl release 89 ENSG00000274513 ENSG00000275463 ENSG00000131042 ENSG00000276146 ENSG00000277751 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cella M Dohring C Samaridis J Dessing M Brockhaus M Lanzavecchia A et al May 1997 A novel inhibitory receptor ILT3 expressed on monocytes macrophages and dendritic cells involved in antigen processing The Journal of Experimental Medicine 185 10 1743 1751 doi 10 1084 jem 185 10 1743 PMC 2196312 PMID 9151699 Samaridis J Colonna M March 1997 Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells structural evidence for new stimulatory and inhibitory pathways European Journal of Immunology 27 3 660 665 doi 10 1002 eji 1830270313 PMID 9079806 S2CID 2212182 a b Entrez Gene LILRB2 leukocyte immunoglobulin like receptor subfamily B with TM and ITIM domains member 2 Mi YJ Chen H Guo N Sun MY Zhao ZH Gao XC et al 2017 Inhibition of PirB Activity by TAT PEP Improves Mouse Motor Ability and Cognitive Behavior Frontiers in Aging Neuroscience 9 199 doi 10 3389 fnagi 2017 00199 PMC 5476690 PMID 28676756 Lao K Zhang R Dai Y Luan J Guo N Xu X et al July 2021 Identification of novel Ab LilrB2 inhibitors as potential therapeutic agents for Alzheimer s disease Molecular and Cellular Neurosciences 114 103630 doi 10 1016 j mcn 2021 103630 PMID 34029694 S2CID 235203153 Kim T Vidal GS Djurisic M William CM Birnbaum ME Garcia KC et al September 2013 Human LilrB2 is a b amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer s model Science 341 6152 1399 1404 Bibcode 2013Sci 341 1399K doi 10 1126 science 1242077 PMC 3853120 PMID 24052308 Fanger NA Cosman D Peterson L Braddy SC Maliszewski CR Borges L November 1998 The MHC class I binding proteins LIR 1 and LIR 2 inhibit Fc receptor mediated signaling in monocytes European Journal of Immunology 28 11 3423 3434 doi 10 1002 SICI 1521 4141 199811 28 11 lt 3423 AID IMMU3423 gt 3 0 CO 2 2 PMID 9842885 Colonna M Samaridis J Cella M Angman L Allen RL O Callaghan CA et al April 1998 Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules Journal of Immunology 160 7 3096 3100 doi 10 4049 jimmunol 160 7 3096 PMID 9531263 S2CID 255370078 Further reading editSuciu Foca N Cortesini R July 2007 Central role of ILT3 in the T suppressor cell cascade Cellular Immunology 248 1 59 67 doi 10 1016 j cellimm 2007 01 013 PMID 17923119 Maruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 174 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Wagtmann N Rojo S Eichler E Mohrenweiser H Long EO August 1997 A new human gene complex encoding the killer cell inhibitory receptors and related monocyte macrophage receptors Current Biology 7 8 615 618 Bibcode 1997CBio 7 615W doi 10 1016 S0960 9822 06 00263 6 PMID 9259559 S2CID 14484039 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 156 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Colonna M Navarro F Bellon T Llano M Garcia P Samaridis J et al December 1997 A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells The Journal of Experimental Medicine 186 11 1809 1818 doi 10 1084 jem 186 11 1809 PMC 2199153 PMID 9382880 Colonna M Samaridis J Cella M Angman L Allen RL O Callaghan CA et al April 1998 Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules Journal of Immunology 160 7 3096 3100 doi 10 4049 jimmunol 160 7 3096 PMID 9531263 S2CID 255370078 Borges L Hsu ML Fanger N Kubin M Cosman D December 1997 A family of human lymphoid and myeloid Ig like receptors some of which bind to MHC class I molecules Journal of Immunology 159 11 5192 5196 doi 10 4049 jimmunol 159 11 5192 PMID 9548455 S2CID 36907307 Fanger NA Cosman D Peterson L Braddy SC Maliszewski CR Borges L November 1998 The MHC class I binding proteins LIR 1 and LIR 2 inhibit Fc receptor mediated signaling in monocytes European Journal of Immunology 28 11 3423 3434 doi 10 1002 SICI 1521 4141 199811 28 11 lt 3423 AID IMMU3423 gt 3 0 CO 2 2 PMID 9842885 Allan DS Colonna M Lanier LL Churakova TD Abrams JS Ellis SA et al April 1999 Tetrameric complexes of human histocompatibility leukocyte antigen HLA G bind to peripheral blood myelomonocytic cells The Journal of Experimental Medicine 189 7 1149 1156 doi 10 1084 jem 189 7 1149 PMC 2193000 PMID 10190906 Lepin EJ Bastin JM Allan DS Roncador G Braud VM Mason DY et al December 2000 Functional characterization of HLA F and binding of HLA F tetramers to ILT2 and ILT4 receptors European Journal of Immunology 30 12 3552 3561 doi 10 1002 1521 4141 200012 30 12 lt 3552 AID IMMU3552 gt 3 0 CO 2 L PMID 11169396 S2CID 42462661 Young NT Canavez F Uhrberg M Shum BP Parham P 2001 Conserved organization of the ILT LIR gene family within the polymorphic human leukocyte receptor complex Immunogenetics 53 4 270 278 doi 10 1007 s002510100332 PMID 11491530 S2CID 2819935 Chang CC Ciubotariu R Manavalan JS Yuan J Colovai AI Piazza F et al March 2002 Tolerization of dendritic cells by T S cells the crucial role of inhibitory receptors ILT3 and ILT4 Nature Immunology 3 3 237 243 doi 10 1038 ni760 PMID 11875462 S2CID 35400503 Willcox BE Thomas LM Chapman TL Heikema AP West AP Bjorkman PJ October 2002 Crystal structure of LIR 2 ILT4 at 1 8 A differences from LIR 1 ILT2 in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18 BMC Structural Biology 2 6 doi 10 1186 1472 6807 2 6 PMC 130215 PMID 12390682 Shiroishi M Tsumoto K Amano K Shirakihara Y Colonna M Braud VM et al July 2003 Human inhibitory receptors Ig like transcript 2 ILT2 and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA G Proceedings of the National Academy of Sciences of the United States of America 100 15 8856 8861 Bibcode 2003PNAS 100 8856S doi 10 1073 pnas 1431057100 PMC 166403 PMID 12853576 Nakajima H Asai A Okada A Ping L Hamajima F Sata T et al December 2003 Transcriptional regulation of ILT family receptors Journal of Immunology 171 12 6611 6620 doi 10 4049 jimmunol 171 12 6611 PMID 14662864 Papanikolaou NA Vasilescu ER Suciu Foca N July 2004 Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin like T cell receptor type 4 Human Immunology 65 7 700 705 doi 10 1016 j humimm 2004 04 003 PMID 15301858 External links editLILRB2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH LILRB2 human gene location in the UCSC Genome Browser LILRB2 human gene details in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This immunology article is a stub You can help Wikipedia by expanding it vte nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LILRB2 amp oldid 1217088808, wikipedia, wiki, book, books, library,
