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Wikipedia

FCGR2A

December 15, 2023

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[5][6]

FCGR2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDsOMIM: 146790 MGI: 95500 HomoloGene: 47936 GeneCards: FCGR2A
Orthologs
SpeciesHumanMouse
Entrez

2212

14131

Ensembl

ENSG00000143226

ENSMUSG00000059498

UniProt

P12318

P08508

RefSeq (mRNA)

NM_001136219
NM_021642
NM_001375296
NM_001375297

NM_010188
NM_001356511

RefSeq (protein)

NP_001129691
NP_067674
NP_001362225
NP_001362226

n/a

Location (UCSC)Chr 1: 161.51 – 161.52 MbChr 1: 170.88 – 170.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

FCGR2A has been shown to interact with PIK3R1[7][8] and Syk.[8][9]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143226 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059498 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
  6. ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
  7. ^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
  8. ^ a b Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
  9. ^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Further reading edit

  • McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID 11913983.
  • Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J. Biol. Chem. 267 (22): 15692–700. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
  • Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor". Immunogenetics. 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077. S2CID 23208039.
  • Hessian PA, Highton J, Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. PMC 1541930. PMID 2527651.
  • Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
  • Lanier LL, Cwirla S, Yu G, et al. (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. 246 (4937): 1611–3. Bibcode:1989Sci...246.1611L. doi:10.1126/science.2531919. PMID 2531919.
  • Stuart SG, Trounstine ML, Vaux DJ, et al. (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. doi:10.1084/jem.166.6.1668. PMC 2188792. PMID 2824655.
  • Hibbs ML, Bonadonna L, Scott BM, et al. (1988). "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. Bibcode:1988PNAS...85.2240H. doi:10.1073/pnas.85.7.2240. PMC 279966. PMID 2965389.
  • Huizinga TW, van der Schoot CE, Jost C, et al. (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature. 333 (6174): 667–9. Bibcode:1988Natur.333..667H. doi:10.1038/333667a0. PMID 2967437. S2CID 4342856.
  • Sammartino L, Webber LM, Hogarth PM, et al. (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics. 28 (5): 380–1. doi:10.1007/BF00364238. PMID 2971615. S2CID 35705081.
  • Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. doi:10.1002/j.1460-2075.1988.tb02913.x. PMC 454434. PMID 3402431.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. PMID 8631888.
  • Salmon JE, Millard S, Schachter LA, et al. (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. doi:10.1172/JCI118552. PMC 507190. PMID 8636449.
  • Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi:10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631.
  • Sármay G, Koncz G, Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. doi:10.1074/jbc.271.48.30499. PMID 8940017.
  • Ibarrola I, Vossebeld PJ, Homburg CH, et al. (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi:10.1182/blood.V91.6.2108. PMID 9490697.

External links edit

  • FCGR2A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

 

This immunology article is a stub. You can help Wikipedia by expanding it.

December 15, 2023
fcgr2a, affinity, immunoglobulin, gamma, region, receptor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1fcg, 1h9v, 3d5o, 3ry4, 3ry5, 3ry6identifiersaliases, cd32, cd32a, cdw32, fcg2, fcgr2, fcgr, igfr2, . Low affinity immunoglobulin gamma Fc region receptor II a is a protein that in humans is encoded by the FCGR2A gene 5 6 FCGR2AAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1FCG 1H9V 3D5O 3RY4 3RY5 3RY6IdentifiersAliasesFCGR2A CD32 CD32A CDw32 FCG2 FCGR2 FCGR2A1 FcGR IGFR2 Fc fragment of IgG receptor IIa FcgammaRIIa Fc gamma receptor IIaExternal IDsOMIM 146790 MGI 95500 HomoloGene 47936 GeneCards FCGR2AGene location Human Chr Chromosome 1 human 1 Band1q23 3Start161 505 430 bp 1 End161 524 013 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H3 1 78 8 cMStart170 878 743 bp 2 End170 892 504 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbloodmonocyteplacentaappendixright lungmetanephric glomerulusspleenupper lobe of left lunggallbladdersynovial membraneTop expressed inspermatocytebloodcalvariabelly cordseminiferous tubuledermisright lung lobemorulaspermatidcervixMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding IgG bindingCellular componentintegral component of membrane plasma membrane membrane secretory granule membrane cell wallBiological processFc gamma receptor signaling pathway involved in phagocytosis immune system process neutrophil degranulation cell adhesionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez221214131EnsemblENSG00000143226ENSMUSG00000059498UniProtP12318P08508RefSeq mRNA NM 001136219NM 021642NM 001375296NM 001375297NM 010188NM 001356511RefSeq protein NP 001129691NP 067674NP 001362225NP 001362226n aLocation UCSC Chr 1 161 51 161 52 MbChr 1 170 88 170 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editFCGR2A has been shown to interact with PIK3R1 7 8 and Syk 8 9 See also editCD32References edit a b c GRCh38 Ensembl release 89 ENSG00000143226 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000059498 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Qiu WQ de Bruin D Brownstein BH Pearse R Ravetch JV June 1990 Organization of the human and mouse low affinity Fc gamma R genes duplication and recombination Science 248 4956 732 5 Bibcode 1990Sci 248 732Q doi 10 1126 science 2139735 PMID 2139735 Entrez Gene FCGR2A Fc fragment of IgG low affinity IIa receptor CD32 Chacko G W Brandt J T Coggeshall K M Anderson C L May 1996 Phosphoinositide 3 kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine based activation motif Reconstitution with synthetic phosphopeptides J Biol Chem 271 18 10775 81 doi 10 1074 jbc 271 18 10775 ISSN 0021 9258 PMID 8631888 a b Ibarrola I Vossebeld P J Homburg C H Thelen M Roos D Verhoeven A J July 1997 Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa Biochim Biophys Acta 1357 3 348 58 doi 10 1016 S0167 4889 97 00034 7 ISSN 0006 3002 PMID 9268059 Kim M K Pan X Q Huang Z Y Hunter S Hwang P H Indik Z K Schreiber A D January 2001 Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis Clin Immunol 98 1 125 32 doi 10 1006 clim 2000 4955 ISSN 1521 6616 PMID 11141335 Further reading editMcKenzie SE 2002 Humanized mouse models of FcR clearance in immune platelet disorders Blood Rev 16 1 3 5 doi 10 1054 blre 2001 0170 PMID 11913983 Ernst LK van de Winkel JG Chiu IM Anderson CL 1992 Three genes for the human high affinity Fc receptor for IgG Fc gamma RI encode four distinct transcription products J Biol Chem 267 22 15692 700 doi 10 1016 S0021 9258 19 49591 4 PMID 1379234 Seki T 1989 Identification of multiple isoforms of the low affinity human IgG Fc receptor Immunogenetics 30 1 5 12 doi 10 1007 BF02421463 PMID 2526077 S2CID 23208039 Hessian PA Highton J Palmer DG 1989 Quantification of macrophage cell surface molecules in rheumatoid arthritis Clin Exp Immunol 77 1 47 51 PMC 1541930 PMID 2527651 Brooks DG Qiu WQ Luster AD Ravetch JV 1989 Structure and expression of human IgG FcRII CD32 Functional heterogeneity is encoded by the alternatively spliced products of multiple genes J Exp Med 170 4 1369 85 doi 10 1084 jem 170 4 1369 PMC 2189488 PMID 2529342 Lanier LL Cwirla S Yu G et al 1990 Membrane anchoring of a human IgG Fc receptor CD16 determined by a single amino acid Science 246 4937 1611 3 Bibcode 1989Sci 246 1611L doi 10 1126 science 2531919 PMID 2531919 Stuart SG Trounstine ML Vaux DJ et al 1987 Isolation and expression of cDNA clones encoding a human receptor for IgG Fc gamma RII J Exp Med 166 6 1668 84 doi 10 1084 jem 166 6 1668 PMC 2188792 PMID 2824655 Hibbs ML Bonadonna L Scott BM et al 1988 Molecular cloning of a human immunoglobulin G Fc receptor Proc Natl Acad Sci U S A 85 7 2240 4 Bibcode 1988PNAS 85 2240H doi 10 1073 pnas 85 7 2240 PMC 279966 PMID 2965389 Huizinga TW van der Schoot CE Jost C et al 1988 The PI linked receptor FcRIII is released on stimulation of neutrophils Nature 333 6174 667 9 Bibcode 1988Natur 333 667H doi 10 1038 333667a0 PMID 2967437 S2CID 4342856 Sammartino L Webber LM Hogarth PM et al 1988 Assignment of the gene coding for human FcRII CD32 to bands q23q24 on chromosome 1 Immunogenetics 28 5 380 1 doi 10 1007 BF00364238 PMID 2971615 S2CID 35705081 Stengelin S Stamenkovic I Seed B 1988 Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning EMBO J 7 4 1053 9 doi 10 1002 j 1460 2075 1988 tb02913 x PMC 454434 PMID 3402431 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Chacko GW Brandt JT Coggeshall KM Anderson CL 1996 Phosphoinositide 3 kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine based activation motif Reconstitution with synthetic phosphopeptides J Biol Chem 271 18 10775 81 doi 10 1074 jbc 271 18 10775 PMID 8631888 Salmon JE Millard S Schachter LA et al 1996 Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans J Clin Invest 97 5 1348 54 doi 10 1172 JCI118552 PMC 507190 PMID 8636449 Bewarder N Weinrich V Budde P et al 1996 In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor FcgammaRII phosphorylation Mol Cell Biol 16 9 4735 43 doi 10 1128 MCB 16 9 4735 PMC 231474 PMID 8756631 Sarmay G Koncz G Gergely J 1997 Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21 ras dependent pathway J Biol Chem 271 48 30499 504 doi 10 1074 jbc 271 48 30499 PMID 8940017 Ibarrola I Vossebeld PJ Homburg CH et al 1997 Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa Biochim Biophys Acta 1357 3 348 58 doi 10 1016 S0167 4889 97 00034 7 PMID 9268059 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 De SK Venkateshan CN Seth P et al 1998 Adenovirus mediated human immunodeficiency virus 1 Nef expression in human monocytes macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines Blood 91 6 2108 17 doi 10 1182 blood V91 6 2108 PMID 9490697 External links editFCGR2A protein human at the U S National Library of Medicine Medical Subject Headings MeSH PDBe KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II a FCGR2A This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte nbsp This immunology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FCGR2A amp oldid 1188048871, wikipedia, wiki, book, books, library,

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