The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000189108 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000059203 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639. S2CID 22262168.
Grundtman C, Salomonsson S, Dorph C, et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies". Arthritis Rheum. 56 (2): 674–87. CiteSeerX10.1.1.489.4969. doi:10.1002/art.22388. PMID 17265504.
Libra M, Mangano K, Anzaldi M, et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders". Oncol. Rep. 15 (5): 1305–8. doi:10.3892/or.15.5.1305. PMID 16596202.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system". Gene. 275 (2): 217–21. doi:10.1016/S0378-1119(01)00659-X. PMID 11587848.
Sana TR, Debets R, Timans JC, et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3". Genomics. 69 (2): 252–62. doi:10.1006/geno.2000.6328. PMID 11031108.
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
Nagaoka H, Ozawa K, Matsuda F, et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16". Genomics. 22 (1): 189–97. doi:10.1006/geno.1994.1360. PMID 7959766.
This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.
il1rapl2, linked, interleukin, receptor, accessory, protein, like, protein, that, humans, encoded, gene, identifiersaliases, il1r9, il1rapl, tigirr, interleukin, receptor, accessory, protein, like, 2external, idsomim, 300277, 1913106, homologene, 9681, genecar. X linked interleukin 1 receptor accessory protein like 2 is a protein that in humans is encoded by the IL1RAPL2 gene 5 6 IL1RAPL2IdentifiersAliasesIL1RAPL2 IL 1R9 IL1R9 IL1RAPL 2 TIGIRR 1 interleukin 1 receptor accessory protein like 2External IDsOMIM 300277 MGI 1913106 HomoloGene 9681 GeneCards IL1RAPL2Gene location Human Chr X chromosome human 1 BandXq22 3Start104 566 199 bp 1 End105 767 829 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X F1Start136 471 357 bp 2 End137 747 695 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inprefrontal cortexright lobe of liverBrodmann area 9placentaurinary bladdergallbladdercingulate gyrusduodenumembryostromal cell of endometriumTop expressed ininternal granular layerPurkinje cellbarrel cortexmedian eminencesuperior frontal gyruspontine nucleineuronpiriform cortextemporal lobeamygdalaMore reference expression dataBioGPSn aGene ontologyMolecular functioninterleukin 1 type II blocking receptor activity interleukin 1 receptor activityCellular componentintegral component of membrane membrane plasma membrane glutamatergic synapseBiological processcentral nervous system development signal transduction cytokine mediated signaling pathway regulation of presynapse assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2628060367EnsemblENSG00000189108ENSMUSG00000059203UniProtQ9NP60Q9ERS6RefSeq mRNA NM 017416NM 030688RefSeq protein NP 059112NP 109613Location UCSC Chr X 104 57 105 77 MbChr X 136 47 137 75 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a member of the interleukin 1 receptor family This protein is similar to the interleukin 1 accessory proteins and is most closely related to interleukin 1 receptor accessory protein like 1 IL1RAPL1 This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X linked non syndromic mental retardation 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000189108 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000059203 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Jin H Gardner RJ Viswesvaraiah R Muntoni F Roberts RG May 2000 Two novel members of the interleukin 1 receptor gene family one deleted in Xp22 1 Xp21 3 mental retardation Eur J Hum Genet 8 2 87 94 doi 10 1038 sj ejhg 5200415 PMID 10757639 S2CID 22262168 a b Entrez Gene IL1RAPL2 interleukin 1 receptor accessory protein like 2 Further reading editGrundtman C Salomonsson S Dorph C et al 2007 Immunolocalization of interleukin 1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies Arthritis Rheum 56 2 674 87 CiteSeerX 10 1 1 489 4969 doi 10 1002 art 22388 PMID 17265504 Libra M Mangano K Anzaldi M et al 2006 Analysis of interleukin IL 1beta IL 1 receptor antagonist soluble IL 1 receptor type II and IL 1 accessory protein in HCV associated lymphoproliferative disorders Oncol Rep 15 5 1305 8 doi 10 3892 or 15 5 1305 PMID 16596202 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ferrante MI Ghiani M Bulfone A Franco B 2001 IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system Gene 275 2 217 21 doi 10 1016 S0378 1119 01 00659 X PMID 11587848 Sana TR Debets R Timans JC et al 2001 Computational identification cloning and characterization of IL 1R9 a novel interleukin 1 receptor like gene encoded over an unusually large interval of human chromosome Xq22 2 q22 3 Genomics 69 2 252 62 doi 10 1006 geno 2000 6328 PMID 11031108 Born TL Smith DE Garka KE et al 2000 Identification and characterization of two members of a novel class of the interleukin 1 receptor IL 1R family Delineation of a new class of IL 1R related proteins based on signaling J Biol Chem 275 39 29946 54 doi 10 1074 jbc M004077200 PMID 10882729 Nagaoka H Ozawa K Matsuda F et al 1994 Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16 Genomics 22 1 189 97 doi 10 1006 geno 1994 1360 PMID 7959766 nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IL1RAPL2 amp oldid 1108535132, wikipedia, wiki, book, books, library,
