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GSK plc

January 01, 1970

GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with global headquarters in London.[3][4] It was established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham,[n 1] which was itself a merger of a number of pharmaceutical companies around the Smith, Kline & French firm.

GSK
Logo since 9 June 2022
FormerlyGlaxoSmithKline (2000–2022)
Company typePublic limited company
Industry
Predecessors
  • Glaxo Wellcome
  • SmithKline Beecham
Founded27 December 2000; 23 years ago (2000-12-27)
HeadquartersLondon, England, UK
Area served
Worldwide
Key people
Products
Revenue £30.328 billion (2023)[1]
£6.745 billion (2023)[1]
£5.308 billion (2023)[1]
Total assets £59.005 billion (2023)[1]
Total equity £12.795 billion (2023)[1]
Number of employees
70,000 (2024)[2]
Subsidiaries
Websitewww.gsk.com

GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck Sharp & Dohme.[5]

The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. As of February 2024, it had a market capitalisation of £69 billion, the eighth largest on the London Stock Exchange.[6]

The company developed the first malaria vaccine, RTS,S, which it said in 2014, it would make available for five per cent above cost.[7] Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such as amoxicillin, mercaptopurine, pyrimethamine and zidovudine.[8]

In 2012, under prosecution by the United States Department of Justice (DoJ) based on combined investigations of the Department of Health and Human Services (HHS-OIG), FDA and FBI, primarily concerning sales and marketing of the drugs Avandia, Paxil and Wellbutrin, GSK pleaded guilty to promotion of drugs for unapproved uses, failure to report safety data and kickbacks to physicians in the United States and agreed to pay a US$3 billion (£1.9bn) settlement. It was the largest health-care fraud case to date in the US and the largest settlement by a Pharmaceutical industry.[9]

History edit

Glaxo Wellcome edit

 
The Glaxo factory built in 1918, in Bunnythorpe, New Zealand, with the Glaxo Laboratories sign still visible

Glaxo edit

Joseph Nathan and Co. was founded in 1873, as a general trading company in Wellington, New Zealand, by a Londoner, Joseph Edward Nathan.[10] In 1904, it began producing a dried-milk baby food from excess milk produced on dairy farms near Bunnythorpe. The resulting product was first known as Defiance, then as Glaxo (from lacto), and sold with the slogan "Glaxo builds bonnie babies."[11][12]: 306 [13] The Glaxo Laboratories sign is still visible on what is now a car repair shop on the main street of Bunnythorpe. The company's first pharmaceutical product, released in 1924, was vitamin D.[12]: 306 

 
Feeder bottle with valve and teat, Glaxo Laboratories, Greenford, Middlesex

Glaxo Laboratories was incorporated as a distinct subsidiary company in London in 1935.[14] Joseph Nathan's shareholders reorganised the group's structure in 1947, making Glaxo the parent[15] and obtained a listing on the London Stock Exchange.[16] Glaxo acquired Allen & Hanburys in 1958. The Scottish pharmacologist David Jack was hired as a researcher for Allen & Hanburys a few years after Glaxo took it over; he went on to lead the company's research and development (R&D) until 1987.[12]: 306  After Glaxo bought Meyer Laboratories in 1978, it began to play an important role in the US market. In 1983, the American arm, Glaxo Inc., moved to Research Triangle Park (US headquarters/research) and Zebulon (US manufacturing) in North Carolina.[13]

Burroughs Wellcome edit

Burroughs Wellcome & Company was founded in 1880, in London by the American pharmacists Henry Wellcome and Silas Burroughs.[17] The Wellcome Tropical Research Laboratories opened in 1902. In the 1920s, Burroughs Wellcome established research and manufacturing facilities in Tuckahoe, New York,[18]: 18 [19][20] which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1971.[21][22] The Nobel Prize winning scientists Gertrude B. Elion and George H. Hitchings worked there and invented drugs still used many years later, such as mercaptopurine.[23] In 1959, the Wellcome Foundation bought Cooper, McDougall & Robertson Inc to become more active in animal health.[13]

When Burroughs Wellcome decided to move its headquarters, the company selected Paul Rudolph to design its new building.[24] The Elion-Hitchings Building "was celebrated worldwide when it was built," according to Paul Rudolph Heritage Foundation president Kelvin Dickinson. Alex Sayf Cummings of Georgia State University wrote in 2016, that the "iconic building helped define the image of RTP," saying, "Love it or hate it, Rudolph's design remains an impressively audacious creative gesture and an important part of the history of both architecture and Research Triangle Park."[25] United Therapeutics, which bought the building in 2012, announced plans in 2020, to tear it down.[25]

Merger edit

Glaxo and Wellcome merged in 1995, to form Glaxo Wellcome plc.[26][12] The merger was then considered the biggest in the UK corporate history.[17] Glaxo Wellcome restructured its R&D operation that year, cutting 10,000 jobs worldwide, closing its R&D facility in Beckenham, Kent, and opening a Medicines Research Centre in Stevenage, Hertfordshire.[27][28][29] Also that year, Glaxo Wellcome acquired the California-based Affymax, a leader in the field of combinatorial chemistry.[30]

By 1999, Glaxo Wellcome had become the world's third-largest pharmaceutical company by revenues (behind Novartis and Merck), with a global market share of around 4 per cent.[31] Its products included Imigran (for the treatment of migraine), salbutamol (Ventolin) (for the treatment of asthma), Zovirax (for the treatment of coldsores), and Retrovir and Epivir (for the treatment of AIDS). In 1999, the company was the world's largest manufacturer of drugs for the treatment of asthma and HIV/AIDS.[32] It employed 59,000 people, including 13,400 in the UK, had 76 operating companies and 50 manufacturing facilities worldwide, and seven of its products were among the world's top 50 best-selling pharmaceuticals. The company had R&D facilities in Hertfordshire, Kent, London and Verona (Italy), and manufacturing plants in Scotland and the north of England. It had R&D centres in the US and Japan, and production facilities in the US, Europe and the Far East.[33]

SmithKline Beecham edit

Beecham edit

Main article: Beecham Group
 
Beecham's Clock Tower, constructed 1877, part of the Beecham's factory, St Helens

In 1848, Thomas Beecham launched his Beecham's Pills laxative in England, giving birth to the Beecham Group. In 1859, Beecham opened its first factory in St Helens, Lancashire. By the 1960s, Beecham was extensively involved in pharmaceuticals and consumer products such as Macleans toothpaste, Lucozade and synthetic penicillin research.[13][34]

SmithKline edit

Main article: SmithKline & French

John K. Smith opened his first pharmacy in Philadelphia in 1830. In 1865, Mahlon Kline joined the business, which 10 years later became Smith, Kline & Co. In 1891, it merged with French, Richard and Company, and in 1929, changed its name to Smith Kline & French Laboratories as it focused more on research. Years later it bought Norden Laboratories, a business doing research into animal health, and Recherche et Industrie Thérapeutiques in Belgium in 1963, to focus on vaccines. The company began to expand globally, buying seven laboratories in Canada and the United States in 1969. In 1982, it bought Allergan, a manufacturer of eye and skincare products.[13]

Smith Kline & French merged with Beckman Inc. in 1982, and changed its name to SmithKline Beckman.[35] In 1988, it bought International Clinical Laboratories.[36]

Merger edit

In 1989, SmithKline Beckman merged with Beecham Group to form SmithKline Beecham P.L.C..[37] The headquarters moved from the United States to England. To expand R&D in the United States, the company bought a new research center in 1995; another opened in 1997, in England at New Frontiers Science Park, Harlow.[13]

2000: Glaxo Wellcome and SmithKline Beecham merger edit

Glaxo Wellcome and SmithKline Beecham announced their intention to merge in January 2000. The merger was completed on 27 December that year, forming GlaxoSmithKline (GSK).[38][39] The company's global headquarters are at GSK House, Brentford, London, officially opened in 2002, by then-Prime Minister Tony Blair. The building was erected at a cost of £300 million and as of 2002 was home to 3,000 administrative staff.[40]

2001–2010 edit

 
Andrew Witty, GSK's CEO from May 2008, to April 2017

GSK completed the acquisition of New Jersey-based Block Drug in 2001, for US$1.24 billion.[41] In 2006, GSK acquired the US-based consumer healthcare company CNS Inc., whose products included Breathe Right nasal strips and FiberChoice dietary supplements, for US$566 million in cash.[42]

Chris Gent, previously CEO of Vodafone, was appointed chairman of the board in 2005.[43] GSK opened its first R&D centre in China in 2007, in Shanghai, initially focused on neurodegenerative diseases.[44] Andrew Witty became the chief executive officer in 2008.[45] Witty joined Glaxo in 1985, and had been president of GSK's Pharmaceuticals Europe since 2003.[46]

In 2009, GSK acquired Stiefel Laboratories, then the world's largest independent dermatology drug company, for US$3.6 billion.[47] In November 2009, the FDA approved GSK's vaccine for 2009 H1N1 influenza protection, manufactured by the company's ID Biomedical Corp in Canada.[48] Also in November 2009, GSK formed a joint venture with Pfizer to create ViiV Healthcare, which specializes in HIV research.[49] In 2010, the company acquired Laboratorios Phoenix, an Argentine pharmaceutical company, for US$253m,[50] and the UK-based sports nutrition company Maxinutrition for £162 million (US$256 million).[51]

2011–2022 edit

In 2011, in a US$660-million deal, Prestige Brands Holdings took over 17 GSK brands with sales of US$210 million, including BC Powder, Beano, Ecotrin, Fiber Choice, Goody's Powder, Sominex and Tagamet.[52] In 2012, the company announced that it would invest £500 million in manufacturing facilities in Ulverston, northern England, designating it as the site for a previously announced biotech plant.[53] In May that year it acquired CellZome, a German biotech company, for US$98 million,[54] and in June, worldwide rights to alitretinoin (Toctino), an eczema drug, for US$302 million.[55] In 2013, GSK acquired Human Genome Sciences (HGS) for US$3 billion; the companies had collaborated on developing the lupus drug Belimumab (Benlysta), albiglutide for type 2 diabetes, and darapladib for atherosclerosis,[56] and in September, sold its beverage division to Suntory. This included the brands Lucozade and Ribena; however, the deal did not include Horlicks.[57]

In March 2014, GSK paid US$1 billion to raise its stake in its Indian pharmaceutical unit, GlaxoSmithKline Pharmaceuticals, to 75 per cent as part of a move to focus on emerging markets.[58] In April 2014, Novartis and Glaxo agreed on more than US$20 billion in deals, with Novartis selling its vaccine business to GSK and buying GSK's cancer business.[59][60] In February 2015, GSK announced that it would acquire GlycoVaxyn, a Swiss pharmaceutical company, for US$190 million,[61] and in June that year that it would sell two meningitis drugs to Pfizer, Nimenrix and Mencevax for around US$130 million.[62]

Philip Hampton, at that time chair of the Royal Bank of Scotland, became GSK chairman in September 2015.[63]

On 31 March 2017, Emma Walmsley became CEO. She is the first female CEO of the company.[64][65]

In December 2017, Reuters reported that Glaxo had increased its stake in its Saudi Arabian unit to 75% (from 49%) taking over control from its Saudi partner Banaja KSA Holding Company.[66]

With respect to rare diseases, the company divested its portfolio of gene therapy drugs to Orchard Therapeutics in April 2018.[67] In November 2018, Reuters reported that Unilever was in prime position to acquire GSK's interest in its Indian unit, GlaxoSmithKline Consumer Healthcare Ltd, in a sale that could generate around US$4 billion for the company.[68] Nestlé and Coca-Cola have also been reported to be interested in the business unit as they look to strengthen their presence in India.[68][69] On 3 December 2018, GSK announced that Unilever would acquire the Indian-listed GlaxoSmithKline Consumer Healthcare business for US$3.8 billion (£2.98 billion). Unilever will pay the majority of the deal in cash, with the remaining being paid in shares in its Indian operation, Hindustan Unilever Limited. Upon completion, GSK will then own around 5.7% of Hindustan Unilever Limited, selling those shares in a number of tranches.[70] The same day, the company also announced it would acquire oncology specialist, Tesaro, for US$5.1 billion. The deal will give GSK control of ovarian cancer treatment, Zejula - a member of the class of poly ADP ribose polymerase (PARP) inhibitors.[71]

In October 2019, GSK agreed to sell its rabies vaccine, RabAvert, and its tick-borne encephalitis vaccine, Encepur, to Bavarian Nordic for US$1.06 billion (€955 million).[72][73]

In July 2020, GSK acquired a 10% stake in German biotech company CureVac.[74]

GSK–Novartis consumer healthcare buy-out edit

In March 2018, GSK announced that it has reached an agreement with Novartis to acquire Novartis's 36.5% stake in their Consumer Healthcare Joint Venture for US$13 billion (£9.2 billion).[75][67]

GSK–Pfizer joint venture edit

In December 2018, GSK announced that it, along with Pfizer, had reached an agreement to merge and combine their consumer healthcare divisions into a single entity. The combined entity would have sales of around £9.8 billion ($12.7 billion), with GSK maintaining a 68% controlling stake in the joint venture. Pfizer would own the remaining 32% shareholding. The deal builds on an earlier 2018 deal where GSK bought out Novartis' stake in the GSK-Novartis consumer healthcare joint business.[76]

Subsequent split edit

 
Prior logo before 9 June 2022

The culmination of the Consumer Healthcare string of deals will result in GSK splitting into two separate companies, via a demerger and subsequent listing of the joint venture. This will create two publicly traded companies, one focusing on pharmaceuticals and research & development, the other on consumer healthcare. On 22 February 2022, GSK announced that the spin-off consumer healthcare company will be called Haleon.[76][77]

In January 2022, the company announced that they had received three unsolicited offers from Unilever to acquire the Consumer Healthcare business unit, with the final proposal valuing the business unit at £50 billion (£41.7 billion in cash, plus £8.3 billion in Unilever shares).[78]

Subsequently, GSK declined all outside offers/attempts to acquire its consumer healthcare business and moved forward with its plan to complete the demerger from the main biopharmaceutical business.[79]

Recent developments edit

In April 2022, the business announced it would acquire Sierra Oncology Inc for $1.9 billion ($55 per share).[80] In May 2022, GSK announced it would acquire Affinivax and its phase II 24-valent pneumococcal vaccine candidate for up to $3.3 billion, strengthening its vaccine business.[81]

On 16 May 2022, the company changed its name from GlaxoSmithKline to GSK.[82]

In April 2023, GSK announced it would acquire Bellus Health Inc. for $2 billion.[83]

In February 2024, the company acquired Aiolos Bio for over $1 billion, adding to its existing asthma business through AIO-001 a long-acting monoclonal antibody that targets the thymic stromal lymphopoietin cytokine.[84][85]

Acquisition-history diagram edit

GlaxoSmithKline Structure
  • GSK
    • GlaxoSmithKline
      • SmithKline Beecham Plc (Renamed 1989)
        • SmithKline Beckman (Renamed 1982)
          • SmithKline-RIT (Renamed 1968)
          • Beckman Instruments, Inc. (Merged 1982, Sold 1989)
            • Specialized Instruments Corp. (Acquired 1954)
            • Offner Electronics (Acquired 1961)
          • International Clinical Laboratories (Acquired 1989)
          • Reckitt & Colman (Acquired 1999)
        • Beecham Group Plc (Merged 1989)
          • Beecham Group Ltd
          • Norcliff Thayer (Acquired 1986)
      • Glaxo Wellcome
        • Glaxo (Merged 1995)
          • Joseph Nathan & Co
          • Allen & Hanburys (Founded 1715, acquired 1958)
          • Meyer Laboratories (Merged 1978)
          • Affymax (Acquired 1995)
        • Wellcome Foundation (Renamed 1924, merged 1995)
          • Burroughs Wellcome & Company (Founded 1880)
          • McDougall & Robertson Inc (Acquired 1959)
    • Block Drug (Acquired 2001)
    • CNS Inc. (Acquired 2006)
    • Stiefel Laboratories (Acquired 2009)
    • Laboratorios Phoenix (Acquired 2010)
    • Maxinutrition (Acquired 2010)
    • CellZome (Acquired 2011)
    • Human Genome Sciences (Acquired 2013)
    • GlycoVaxyn (Acquired 2015)
    • Tesaro (Acquired 2019)
    • Sitari Pharmaceuticals (Acquired 2019)
    • Sierra Oncology (Acquired 2022)
    • Affinivax (Acquired 2022)
    • Bellus Health Inc. (Acquired 2023)
    • Aiolos Bio (Acquired 2024)

Research areas and products edit

Further information: List of GSK plc products

Pharmaceuticals edit

GSK manufactures products for major disease areas such as asthma, cancer, infections, diabetes, and mental health. Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin[86] and amoxicillin-clavulanate,[87] ticarcillin-clavulanate,[88] mupirocin,[89] and ceftazidime[90] for bacterial infections, zidovudine for HIV infection, valacyclovir for herpes virus infections, albendazole for parasitic infections, sumatriptan for migraine, lamotrigine for epilepsy, bupropion and paroxetine for major depressive disorder, cimetidine and ranitidine for gastroesophageal reflux disorder, mercaptopurine[91] and thioguanine[92] for the treatment of leukemia, allopurinol for gout,[93] pyrimethamine for malaria,[94] and the antibacterial trimethoprim.[92]

Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupirocin, pyrimethamine, ranitidine, thioguanine, trimethoprim, and zidovudine are on the World Health Organization's List of Essential Medicines.[8]

Malaria vaccine edit

In 2014, GSK applied for regulatory approval for the first malaria vaccine.[7] Malaria is responsible for over 650,000 deaths annually, mainly in Africa.[95] Known as RTS,S, the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates Foundation. The company has committed to making the vaccine available in developing countries for five per cent above the cost of production.[7]

As of 2013, RTS,S, which uses GSK's proprietary AS01 adjuvant, was being examined in a Phase 3 trial in eight African countries. PATH reported that "[i]n the 12-month period following vaccination, RTS,S conferred approximately 50% protection from clinical Plasmodium falciparum disease in children aged 5-17 months, and approximately 30% protection in children aged 6-12 weeks when administered in conjunction with Expanded Program for Immunization (EPI) vaccines."[96] In 2014, Glaxo said it had spent more than US$350 million and expected to spend an additional US$260 million before seeking regulatory approval.[97][98]

Consumer healthcare edit

GSK's consumer healthcare division, which earned £5.2 billion in 2013, sells oral healthcare, including Aquafresh, Macleans and Sensodyne toothpastes. GSK also previously owned the Lucozade and Ribena brands of soft drinks, but they were sold in 2013, to Suntory for £1.35bn.[57] Other products include Abreva to treat cold sores; Night Nurse, a cold remedy; Breathe Right nasal strips; and Nicoderm and Nicorette nicotine replacements.[99] In March 2014, it recalled Alli, an over-the-counter weight-loss drug, in the United States and Puerto Rico because of possible tampering, following customer complaints.[100]

Facilities edit

As of 2013, GSK had offices in over 115 countries and employed over 99,000 people, 12,500 in R&D. The company's single largest market is the United States. Its US headquarters are in Philadelphia, Pennsylvania and Durham, North Carolina; its consumer-products division is in Moon Township, Pennsylvania.[101]

COVID-19 vaccine edit

Main article: Sanofi–GSK COVID-19 vaccine

In July 2020, the UK government signed up for 60 million doses of a COVID-19 vaccine developed by GSK and Sanofi. It uses a recombinant protein-based technology from Sanofi and GSK's pandemic technology. The companies claimed to be able to produce one billion doses, subject to successful trials and regulatory approval, during the first half of 2021.[102] The company also agreed to a $2.1 billion deal with the United States to produce 100 million doses of the vaccine.[103]

Venture arms edit

SR One was established in 1985, by SmithKline Beecham to invest in new biotechnology companies and continued operating after GSK was formed; by 2003, GSK had formed another subsidiary, GSK Ventures, to out-license or start new companies around drug candidates that it did not intend to develop further.[104] As of 2003, SR One tended to invest only if the company aligned with GSK's business.[104]

In September 2019, Avalon Ventures announced that it entered into a definitive agreement with GlaxoSmithKline (GSK) for the acquisition of Sitari Pharmaceuticals by GSK. This includes its transglutaminase 2 (TG2) small molecule program for the treatment of celiac disease.[105]

Recognition, philanthropy and social responsibility edit

Scientific recognition edit

Four GlaxoSmithKline scientists have been recognized by the Nobel Committee for their contributions to basic medical science and/or therapeutics development.

  • Henry Dale, a former student of Paul Ehrlich, received the 1936 Nobel Prize in Medicine for his work on the chemical transmission of neural impulses. Dale served as a pharmacologist and then as Director of the Wellcome Physiological Research Laboratories from 1904 to 1914, and later served as Trustee and chairman of the board of the Wellcome Trust.[106]
  • John Vane of Wellcome Research Laboratories shared the 1982 Nobel Prize for Medicine for his work on prostaglandin biology and the discovery of prostacyclin. Vane served as group research and development director for The Wellcome Foundation from 1973 to 1985.[107]
  • Gertrude B. Elion and George Hitchings, both of the Wellcome Research Laboratories, shared the 1988 Nobel Prize in Medicine with Sir James W. Black, formerly of Smith Kline & French and the Wellcome Foundation, ""for their discoveries of important principles for drug treatment"." Elion and Hitchings were responsible for the discovery of a plethora of important drugs, including mercaptopurine[91] and thioguanine[92] for the treatment of leukemia, the immunosuppressant azothioprine,[108] allopurinol for gout,[93] pyrimethamine for malaria,[94] the antibacterial trimethoprim,[92] acyclovir for herpes virus infection,[109] and nelarabine for cancer treatment.[110]

Philanthropy and social responsibility edit

Since 2010, GlaxoSmithKline has several times ranked first among pharmaceutical companies on the Global Access to Medicines Index, which is funded by the Bill and Melinda Gates Foundation.[111] In 2014, the Human Rights Campaign, an LGBT-rights advocacy group gave GSK a score of 100 per cent in its Corporate Equality Index.[112]

GSK has been active, with the World Health Organization (WHO), in the Global Alliance to Eliminate Lymphatic Filariasis (GAELF). Around 120 million people globally are believed to be infected with lymphatic filariasis.[113] In 2012, the company endorsed the London Declaration on Neglected Tropical Diseases; it agreed to donate 400 million albendazole tablets to the WHO each year to fight soil-transmitted helminthiasis and to provide 600 million albendazole tablets every year for lymphatic filariasis until the disease is eradicated.[114] As of 2014, over 5 billion treatments had been delivered, and 18 of 73 countries in which the disease is considered endemic had progressed to the surveillance stage.[115]

In 2009, the company said it would cut drug prices by 25 per cent in 50 of the poorest nations, release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development, and invest 20 per cent of profits from the least-developed countries in medical infrastructure for those countries.[116][117] Médecins Sans Frontières welcomed the decision, but criticized GSK for failing to include HIV patents in its patent pool and for not including middle-income countries in the initiative.[118]

In 2013, GSK licensed its HIV portfolio to the Medicines Patent Pool for use in children, and agreed to negotiate a license for dolutegravir, an integrase inhibitor then in clinical development.[119] In 2014, this license was extended to include dolutegravir and adults with HIV. The licenses include countries in which 93 per cent of adults and 99 per cent of children with HIV live.[120] Also in 2013 GSK joined AllTrials, a British campaign to ensure that all clinical trials are registered and the results reported. The company said it would make its past clinical-trial reports available and future ones within a year of the studies' end.[121]

GSK has largely had an access strategy, providing medicines at a subsidized price to lower and middle income markets including Africa under the former CEO Andrew Witty. In 2017, its new CEO, Emma Walmsley,[122] shifted away from this with GSK exiting all Sub-Saharan African markets and there being no plans to provide its newer expensive oncology and genetics pipeline to this population.[123]

Controversies edit

1973 Antitrust case over griseofulvin edit

In the 1960s, Glaxo Group Ltd. (Glaxo) and Imperial Chemical Industries (ICI) each owned patents covering various aspects of the antifungal drug griseofulvin.[124]: 54, nn. 1–2 [125] They created a patent pool by cross-licensing their patents, subject to express licensing restrictions that the chemical from which the "finished" form of the drug (tablets and capsules) was made must not be resold in bulk form, and they licensed other drug companies to sell the drug in finished form and subject to similar restrictions.[124]: 54–55 [125] The effect and intent of the bulk-sale restriction was to keep the drug chemical out of the hands of small companies that might act as price-cutters, and the effect was to maintain stable, uniform prices.[126][127][128]

The United States brought an antitrust suit against the two companies—United States v. Glaxo Group Ltd.—charging them with violation of the Sherman Act and also seeking to have the patents declared invalid.[124]: 55 [125] The trial court found that the defendants had engaged in several unlawful conspiracies, but dismissed the part of the suit seeking invalidation of patents and refused to grant as relief mandatory sales of the bulk drug chemical and compulsory licensing of the patents.[124]: 56 [125] The government appealed to the Supreme Court, which reversed, in United States v. Glaxo Group Ltd., 410 U.S. 52 (1973).[125]

2000s Ribena edit

 
 
Old Ribena bottle, year unknown, made by Beecham Products, Brentford, Middlesex; the label states: "widely used in hospitals and clinics."

There were concerns in the 2000s about the sugar and vitamin content of Ribena, a blackcurrant-based syrup and soft drink owned by GSK until 2013. Produced in England by H.W. Carter & Co from the 1930s, the company's unbranded syrup was distributed to children as a source of vitamin C during World War II, which gave the drink a reputation as good for health. Beecham bought H. W. Carter in 1955.[129]

In 2001, the British Advertising Standards Authority (ASA) required GSK to withdraw its claim that Ribena Toothkind, a lower-sugar variety, did not encourage tooth decay. A company poster showed bottles of Toothkind in place of the bristles on a toothbrush. The ASA's ruling was upheld by the High Court.[130] In 2007, GSK was fined US$217,000 in New Zealand over its claim that ready-to-drink Ribena contained high levels of vitamin C, after it was found to contain no detectable vitamin C.[131] In 2013, GSK sold Ribena and another drink, Lucozade, to the Japanese multinational Suntory for £1.35 billion.[57]

SB Pharmco Puerto Rico edit

In 2010, the US Department of Justice announced that GSK would pay a US$150 million criminal fine and forfeiture, and a civil settlement of US$600 million under the False Claims Act. The fines stemmed from production of improperly made and adulterated drugs from 2001 to 2005, at GSK's subsidiary, SB Pharmco Puerto Rico Inc., in Cidra, Puerto Rico, which at the time produced US$5.5 billion of products each year. The drugs involved were Kytril, an antiemetic; Bactroban, used to treat skin infections; Paxil, the anti-depressant; and Avandamet, a diabetes drug.[132] GSK closed the factory in 2009.[133]

The case began in 2002, when GSK sent experts to fix problems cited by the FDA. The lead inspector recommended recalls of defective products, but they were not authorised; she was fired in 2003, and filed a whistleblower lawsuit. In 2005, federal marshals seized US$2 billion worth of products, the largest such seizure in history. In the 2010 settlement SB Pharmco pleaded guilty to criminal charges, and agreed to pay US$150 million in a criminal fine and forfeiture, at that time the largest such payment ever by a manufacturer of adulterated drugs, and US$600 million in civil penalties to settle the civil lawsuit.[133]

2010 Pandemrix connected with narcolepsy edit

The Pandemrix influenza vaccine was developed by GlaxoSmithKline in 2006. It was used by Finland and Sweden in the H1N1 mass vaccination of the population against the 2009 swine flu pandemic. In August 2010, The Swedish Medical Products Agency (MPA) and The Finnish National Institute for Health and Welfare (THL) launched investigations regarding the development of narcolepsy as a possible side effect to Pandemrix flu vaccination in children,[134] and found a 6.6-fold increased risk among children and youths, resulting in 3.6 additional cases of narcolepsy per 100,000 vaccinated subjects.[135]

In February 2011, The Finnish National Institute for Health and Welfare (THL) concluded that there is a clear connection between the Pandemrix vaccination campaign of 2009 and 2010, and the narcolepsy epidemic in Finland. A total of 152 cases of narcolepsy were found in Finland during 2009–2010, and ninety per cent of them had received the Pandemrix vaccination.[136][137][138] Sweden however observed very few influenza cases totally in 2009 and especially 2010 as compared to most other years.[139] In 2015, it was reported that the British Department of Health was paying for Sodium oxybate medication for 80 patients who are taking legal action over problems linked to the use of the swine flu vaccine, at a cost to the government of £12,000 per patient per year.[140]

2012 criminal and civil settlement edit

Overview edit

In July 2012, GSK pleaded guilty in the United States to criminal charges, and agreed to pay US$3 billion, in what was the largest settlement until then between the Justice Department and a drug company. The US$3 billion included a criminal fine of US$956,814,400 and forfeiture of US$43,185,600. The remaining US$2 billion covered a civil settlement with the government under the False Claims Act. The investigation was launched largely on the basis of information from four whistleblowers who filed qui tam (whistleblower) lawsuits against the company under the False Claims Act.[9]

The charges stemmed from GSK's promotion of the anti-depressants Paxil (paroxetine) and Wellbutrin (bupropion) for unapproved uses from 1998 to 2003, specifically as suitable for patients under the age of 18, and from its failure to report safety data about Avandia (rosiglitazone), both in violation of the Federal Food, Drug, and Cosmetic Act. Other drugs promoted for unapproved uses were two inhalers, Advair (fluticasone/salmeterol) and Flovent (fluticasone propionate), as well as Zofran (ondansetron), Imitrex (sumatriptan), Lotronex (alosetron) and Valtrex (valaciclovir).[9]

The settlement also covered reporting false best prices and underpaying rebates owed under the Medicaid Drug Rebate Program, and kickbacks to physicians to prescribe GSK's drugs. There were all-expenses-paid spa treatments and hunting trips for doctors and their spouses, speakers' fees at conferences, and payment for articles ghostwritten by the company and placed by physicians in medical journals.[9] The company set up a ghostwriting programme called CASPPER, initially to produce articles about Paxil but which was extended to cover Avandia.[141]

As part of the settlement GSK signed a five-year corporate integrity agreement with the Department of Health and Human Services, which obliged the company to make major changes in the way it did business, including changing its compensation programmes for its sales force and executives, and to implement and maintain transparency in its research practices and publication policies.[9] It announced in 2013, that it would no longer pay doctors to promote its drugs or attend medical conferences, and that its sales staff would no longer have prescription targets.[142]

Rosiglitazone (Avandia) edit

Further information: Rosiglitazone § Adverse effects, and Rosiglitazone § Lawsuits
 
Rosiglitazone

The 2012 settlement included a criminal fine of US$242,612,800 for failing to report safety data to the FDA about Avandia (rosiglitazone), a diabetes drug approved in 1999, and a civil settlement of US$657 million for making false claims about it. The Justice Department said GSK had promoted rosiglitazone to physicians with misleading information, including that it conferred cardiovascular benefits despite an FDA-mandated label warning of cardiovascular risks.[9]

In 1999, John Buse, a diabetes specialist, told medical conferences that rosiglitazone might carry an increased risk of cardiovascular problems. GSK threatened to sue him, called his university head of department, and persuaded him to sign a retraction.[143] GSK raised questions internally about the drug's safety in 2000, and in 2002, the company ghostwrote an article in Circulation describing a GSK funded clinical trial that suggested rosiglitazone might have a beneficial effect on cardiovascular risk.[144] From 2001, reports began to link the thiazolidinediones (the class of drugs to which rosiglitazone belongs) to heart failure.[145] In April that year, GSK began a six-year, open-label, randomized trial, known as RECORD, to examine rosiglitazone and cardiovascular events.[146] Two GSK meta-analyses in 2005, and 2006, showed an increased risk of cardiovascular problems with rosiglitazone; the information was passed to the FDA and posted on the company website, but not otherwise published. By December 2006, rosiglitazone had become the top-selling diabetes drug, with annual sales of US$3.3 billion.[145]

In June 2007, The New England Journal of Medicine published a meta-analysis that associated the drug with an increased risk of heart attack.[147] GSK had reportedly tried to persuade one of the authors, Steven Nissen, not to publish it, after receiving an advance copy from one of the journal's peer reviewers, a GSK consultant.[148][149] In July 2007, FDA scientists suggested that rosiglitazone had caused 83,000 excess heart attacks between 1999 and 2007.[150]: 4 [151] The FDA placed restrictions on the drug, including adding a boxed warning, but did not withdraw it.[152] (In 2013, the FDA rejected that the drug had caused excess heart attacks.)[153] A Senate Finance Committee inquiry concluded in 2010, that GSK had sought to intimidate scientists who had concerns about rosiglitazone.[150] In February that year the company tried to halt publication of an editorial about the controversy by Nissen in the European Heart Journal.[154]

The results of GSK's RECORD trial were published in June 2009. It confirmed an association between rosiglitazone and an increased risk of heart failure and fractures, but not of heart attack, and concluded that it "does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose-lowering drugs."[146] Steven Nissan and Kathy Wolkski argued that the study's low event rates reduced its statistical power.[155] In September 2009, rosiglitazone was suspended in Europe.[156] The results of the RECORD study were confirmed in 2013, by the Duke Clinical Research Institute, in an independent review required by the FDA.[157] In November that year the FDA lifted the restrictions it had placed on the drug.[158] The boxed warning about heart attack was removed; the warning about heart failure remained in place.[153]

Paroxetine (Paxil/Seroxat) edit

Main article: Study 329
 
Paroxetine, known as Paxil and Seroxat

GSK was fined for promoting Paxil/Seroxat (paroxetine) for treating depression in the under-18s, although the drug had not been approved for pediatric use.[9] Paxil had US$4.97 billion worldwide sales in 2003.[159] The company conducted nine clinical trials between 1994, and 2002, none of which showed that Paxil helped children with depression.[160] From 1998, to 2003, it promoted the drug for the under-18s, paying physicians to go on all-expenses paid trips, five-star hotels and spas.[9] From 2004, Paxil's label, along with those of similar drugs, included an FDA-mandated boxed warning that it might increase the risk of suicidal ideation and behaviour in patients under 18.[9]

An internal SmithKline Beecham document said in 1998, about withheld data from two GSK studies: "It would be commercially unacceptable to include a statement that [pediatric] efficacy had not been demonstrated, as this would undermine the profile of paroxetine."[159][161] The company ghostwrote an article, published in 2001, in the Journal of the American Academy of Child and Adolescent Psychiatry, that misreported the results of one of its clinical trials, Study 329.[9][162] The article concluded that Paxil was "generally well tolerated and effective for major depression in adolescents."[163] The suppression of the research findings is the subject of the 2008 book Side Effects by Alison Bass.[164][165]

For 10 years GSK marketed Paxil as non-habit forming. In 2001, 35 patients filed a class-action suit alleging they had had withdrawal symptoms, and in 2002, a Los Angeles court issued an injunction preventing GSK from advertising that the drug was not habit forming.[166] The court withdrew the injunction after the FDA objected that the court had no jurisdiction over drug marketing that the FDA had approved.[167] In 2003, a World Health Organization committee reported that Paxil was among the top 30 drugs, and top three antidepressants, for which dependence had been reported.[168][n 2]

Bupropion (Wellbutrin) edit

The company was also fined for promoting Wellbutrin (bupropion) – approved at the time for major depressive disorder and also sold as a smoking-cessation aid, Zyban – for weight loss and the treatment of attention deficit hyperactivity disorder, sexual dysfunction and substance addiction. GSK paid doctors to promote these off-label uses, and set up supposedly independent advisory boards and Continuing Medical Education programmes.[9]

China edit

Main article: GSK China Scandal

In 2013, Chinese authorities announced that, since 2007, GSK had funnelled HK$3.8 billion in kickbacks to GSK managers, doctors, hospitals and others who prescribed their drugs, using over 700 travel agencies and consulting firms.[169] Chinese authorities arrested four GSK executives as part of a four-month investigation into claims that doctors were bribed with cash and sexual favours.[170] In 2014, a Chinese court found the company guilty of bribery and imposed a fine of US$490 million. Mark Reilly, the British head of GSK's Chinese operations, received a three-year suspended prison sentence after a one-day trial held in secret.[171] Reilly was reportedly deported from China and dismissed by the company.[172]

Market manipulation in the UK edit

In February 2016, the company was fined over £37 million in the UK by the Competition and Markets Authority for paying Generics UK, Alpharma and Norton Healthcare more than £50m between 2001, and 2004, to keep generic varieties of paroxetine out of the UK market. The generics companies were fined a further £8 million. At the end of 2003, when generics became available in the UK, the price of paroxetine dropped by 70 per cent.[173]

Miscellaneous edit

Italian police sought bribery charges in May 2004, against 4,400 doctors and 273 GSK employees. GSK and its predecessor were accused of having spent £152m on physicians, pharmacists and others, giving them cameras, computers, holidays and cash. Doctors were alleged to have received cash based on the number of patients they treated with a cancer drug, topotecan (Hycamtin).[174] The following month prosecutors in Munich accused 70–100 doctors of having accepted bribes from SmithKline Beecham between 1997, and 1999. The inquiry was opened over allegations that the company had given over 4,000 hospital doctors money and free trips.[175][176] All charges were dismissed by the Verona court in January 2009.[177]

In 2006, in the United States GSK settled the largest tax dispute in IRS history, agreeing to pay US$3.1 billion. At issue were Zantac and other products sold in 1989–2005. The case revolved around intracompany transfer pricing—determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS.[178][179]

The UK's Serious Fraud Office (SFO) opened a criminal inquiry in 2014 into GSK's sales practices, using powers granted by the Bribery Act 2010.[180] The SFO said it was collaborating with Chinese authorities to investigate bringing charges in the UK related to GSK's activities in China, Europe and the Middle East.[181] Also as of 2014, the US Department of Justice was investigating GSK with reference to the Foreign Corrupt Practices Act.[182]

In October 2020, GSK told some staff that while at work they should disable the contact tracing function of the NHS test-and-trace app which monitors the spread of COVID-19. GSK explained the reason for this was due to social distancing measures in place at their sites rendering the technology unnecessary.[183]

See also edit

51°29′17″N 0°19′1″W / 51.48806°N 0.31694°W / 51.48806; -0.31694

Notes edit

  1. ^ Glaxo Wellcome was formed from Glaxo's 1995 acquisition of The Wellcome Foundation and SmithKline Beecham from the 1989 merger of the Beecham Group and the SmithKline Beckman Corporation.
  2. ^ World Health Organization Expert Committee on Drug Dependence, 2003: "The Committee noted the striking number of reports on paroxetine and 'withdrawal syndrome' ... The representative of Consumers International reported that a number of patients had experienced difficulty in withdrawing from SSRIs in general. It was agreed that withdrawal was indeed a problem in some patients, but there was a difference of opinion on the degree of dependence that was involved, given the possibility that the need for treatment of resistant or relapsing disease could make these drugs indispensable for patient care. The Committee expressed concern about the possibility of inappropriate prescribing resulting in the risk of problems of withdrawal outweighing the benefits of treatment with SSRIs."[168]

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External links edit

  • Official website
  • Business data for GSK plc:
    • Bloomberg
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  • GSK plc companies grouped at OpenCorporates

January 01, 1970
acronym, from, former, name, glaxosmithkline, british, multinational, pharmaceutical, biotechnology, company, with, global, headquarters, london, established, 2000, merger, glaxo, wellcome, smithkline, beecham, which, itself, merger, number, pharmaceutical, co. GSK plc an acronym from its former name GlaxoSmithKline plc is a British multinational pharmaceutical and biotechnology company with global headquarters in London 3 4 It was established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham n 1 which was itself a merger of a number of pharmaceutical companies around the Smith Kline amp French firm GSKLogo since 9 June 2022FormerlyGlaxoSmithKline 2000 2022 Company typePublic limited companyTraded asLSE GSK FTSE 100 ComponentIndustryPharmaceuticalBiotechnologyPredecessorsGlaxo WellcomeSmithKline BeechamFounded27 December 2000 23 years ago 2000 12 27 HeadquartersLondon England UKArea servedWorldwideKey peopleJonathan Symonds Chairperson Emma Walmsley CEO ProductsPharmaceutical drugsvaccinesRevenue 30 328 billion 2023 1 Operating income 6 745 billion 2023 1 Net income 5 308 billion 2023 1 Total assets 59 005 billion 2023 1 Total equity 12 795 billion 2023 1 Number of employees70 000 2024 2 SubsidiariesHaleon 7 4 Stiefel Laboratories Tesaro ViiV Healthcare 76 5 Websitewww wbr gsk wbr com GSK is the tenth largest pharmaceutical company and 294 on the 2022 Fortune Global 500 ranked behind other pharmaceutical companies China Resources Sinopharm Johnson amp Johnson Pfizer Roche AbbVie Novartis Bayer and Merck Sharp amp Dohme 5 The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index As of February 2024 it had a market capitalisation of 69 billion the eighth largest on the London Stock Exchange 6 The company developed the first malaria vaccine RTS S which it said in 2014 it would make available for five per cent above cost 7 Legacy products developed at GSK include several listed in the World Health Organization s List of Essential Medicines such as amoxicillin mercaptopurine pyrimethamine and zidovudine 8 In 2012 under prosecution by the United States Department of Justice DoJ based on combined investigations of the Department of Health and Human Services HHS OIG FDA and FBI primarily concerning sales and marketing of the drugs Avandia Paxil and Wellbutrin GSK pleaded guilty to promotion of drugs for unapproved uses failure to report safety data and kickbacks to physicians in the United States and agreed to pay a US 3 billion 1 9bn settlement It was the largest health care fraud case to date in the US and the largest settlement by a Pharmaceutical industry 9 Contents 1 History 1 1 Glaxo Wellcome 1 1 1 Glaxo 1 1 2 Burroughs Wellcome 1 1 3 Merger 1 2 SmithKline Beecham 1 2 1 Beecham 1 2 2 SmithKline 1 2 3 Merger 1 3 2000 Glaxo Wellcome and SmithKline Beecham merger 1 4 2001 2010 1 5 2011 2022 1 5 1 GSK Novartis consumer healthcare buy out 1 5 2 GSK Pfizer joint venture 1 5 3 Subsequent split 1 6 Recent developments 1 6 1 Acquisition history diagram 2 Research areas and products 2 1 Pharmaceuticals 2 2 Malaria vaccine 2 3 Consumer healthcare 2 4 Facilities 2 5 COVID 19 vaccine 3 Venture arms 4 Recognition philanthropy and social responsibility 4 1 Scientific recognition 4 2 Philanthropy and social responsibility 5 Controversies 5 1 1973 Antitrust case over griseofulvin 5 2 2000s Ribena 5 3 SB Pharmco Puerto Rico 5 4 2010 Pandemrix connected with narcolepsy 5 5 2012 criminal and civil settlement 5 5 1 Overview 5 5 2 Rosiglitazone Avandia 5 5 3 Paroxetine Paxil Seroxat 5 5 4 Bupropion Wellbutrin 5 6 China 5 7 Market manipulation in the UK 5 8 Miscellaneous 6 See also 7 Notes 8 References 9 External linksHistory editGlaxo Wellcome edit nbsp The Glaxo factory built in 1918 in Bunnythorpe New Zealand with the Glaxo Laboratories sign still visible Glaxo edit Joseph Nathan and Co was founded in 1873 as a general trading company in Wellington New Zealand by a Londoner Joseph Edward Nathan 10 In 1904 it began producing a dried milk baby food from excess milk produced on dairy farms near Bunnythorpe The resulting product was first known as Defiance then as Glaxo from lacto and sold with the slogan Glaxo builds bonnie babies 11 12 306 13 The Glaxo Laboratories sign is still visible on what is now a car repair shop on the main street of Bunnythorpe The company s first pharmaceutical product released in 1924 was vitamin D 12 306 nbsp Feeder bottle with valve and teat Glaxo Laboratories Greenford Middlesex Glaxo Laboratories was incorporated as a distinct subsidiary company in London in 1935 14 Joseph Nathan s shareholders reorganised the group s structure in 1947 making Glaxo the parent 15 and obtained a listing on the London Stock Exchange 16 Glaxo acquired Allen amp Hanburys in 1958 The Scottish pharmacologist David Jack was hired as a researcher for Allen amp Hanburys a few years after Glaxo took it over he went on to lead the company s research and development R amp D until 1987 12 306 After Glaxo bought Meyer Laboratories in 1978 it began to play an important role in the US market In 1983 the American arm Glaxo Inc moved to Research Triangle Park US headquarters research and Zebulon US manufacturing in North Carolina 13 Burroughs Wellcome edit Burroughs Wellcome amp Company was founded in 1880 in London by the American pharmacists Henry Wellcome and Silas Burroughs 17 The Wellcome Tropical Research Laboratories opened in 1902 In the 1920s Burroughs Wellcome established research and manufacturing facilities in Tuckahoe New York 18 18 19 20 which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1971 21 22 The Nobel Prize winning scientists Gertrude B Elion and George H Hitchings worked there and invented drugs still used many years later such as mercaptopurine 23 In 1959 the Wellcome Foundation bought Cooper McDougall amp Robertson Inc to become more active in animal health 13 When Burroughs Wellcome decided to move its headquarters the company selected Paul Rudolph to design its new building 24 The Elion Hitchings Building was celebrated worldwide when it was built according to Paul Rudolph Heritage Foundation president Kelvin Dickinson Alex Sayf Cummings of Georgia State University wrote in 2016 that the iconic building helped define the image of RTP saying Love it or hate it Rudolph s design remains an impressively audacious creative gesture and an important part of the history of both architecture and Research Triangle Park 25 United Therapeutics which bought the building in 2012 announced plans in 2020 to tear it down 25 Merger edit Glaxo and Wellcome merged in 1995 to form Glaxo Wellcome plc 26 12 The merger was then considered the biggest in the UK corporate history 17 Glaxo Wellcome restructured its R amp D operation that year cutting 10 000 jobs worldwide closing its R amp D facility in Beckenham Kent and opening a Medicines Research Centre in Stevenage Hertfordshire 27 28 29 Also that year Glaxo Wellcome acquired the California based Affymax a leader in the field of combinatorial chemistry 30 By 1999 Glaxo Wellcome had become the world s third largest pharmaceutical company by revenues behind Novartis and Merck with a global market share of around 4 per cent 31 Its products included Imigran for the treatment of migraine salbutamol Ventolin for the treatment of asthma Zovirax for the treatment of coldsores and Retrovir and Epivir for the treatment of AIDS In 1999 the company was the world s largest manufacturer of drugs for the treatment of asthma and HIV AIDS 32 It employed 59 000 people including 13 400 in the UK had 76 operating companies and 50 manufacturing facilities worldwide and seven of its products were among the world s top 50 best selling pharmaceuticals The company had R amp D facilities in Hertfordshire Kent London and Verona Italy and manufacturing plants in Scotland and the north of England It had R amp D centres in the US and Japan and production facilities in the US Europe and the Far East 33 SmithKline Beecham edit Beecham edit Main article Beecham Group nbsp Beecham s Clock Tower constructed 1877 part of the Beecham s factory St Helens In 1848 Thomas Beecham launched his Beecham s Pills laxative in England giving birth to the Beecham Group In 1859 Beecham opened its first factory in St Helens Lancashire By the 1960s Beecham was extensively involved in pharmaceuticals and consumer products such as Macleans toothpaste Lucozade and synthetic penicillin research 13 34 SmithKline edit Main article SmithKline amp French John K Smith opened his first pharmacy in Philadelphia in 1830 In 1865 Mahlon Kline joined the business which 10 years later became Smith Kline amp Co In 1891 it merged with French Richard and Company and in 1929 changed its name to Smith Kline amp French Laboratories as it focused more on research Years later it bought Norden Laboratories a business doing research into animal health and Recherche et Industrie Therapeutiques in Belgium in 1963 to focus on vaccines The company began to expand globally buying seven laboratories in Canada and the United States in 1969 In 1982 it bought Allergan a manufacturer of eye and skincare products 13 Smith Kline amp French merged with Beckman Inc in 1982 and changed its name to SmithKline Beckman 35 In 1988 it bought International Clinical Laboratories 36 Merger edit In 1989 SmithKline Beckman merged with Beecham Group to form SmithKline Beecham P L C 37 The headquarters moved from the United States to England To expand R amp D in the United States the company bought a new research center in 1995 another opened in 1997 in England at New Frontiers Science Park Harlow 13 2000 Glaxo Wellcome and SmithKline Beecham merger edit Glaxo Wellcome and SmithKline Beecham announced their intention to merge in January 2000 The merger was completed on 27 December that year forming GlaxoSmithKline GSK 38 39 The company s global headquarters are at GSK House Brentford London officially opened in 2002 by then Prime Minister Tony Blair The building was erected at a cost of 300 million and as of 2002 update was home to 3 000 administrative staff 40 2001 2010 edit nbsp Andrew Witty GSK s CEO from May 2008 to April 2017 GSK completed the acquisition of New Jersey based Block Drug in 2001 for US 1 24 billion 41 In 2006 GSK acquired the US based consumer healthcare company CNS Inc whose products included Breathe Right nasal strips and FiberChoice dietary supplements for US 566 million in cash 42 Chris Gent previously CEO of Vodafone was appointed chairman of the board in 2005 43 GSK opened its first R amp D centre in China in 2007 in Shanghai initially focused on neurodegenerative diseases 44 Andrew Witty became the chief executive officer in 2008 45 Witty joined Glaxo in 1985 and had been president of GSK s Pharmaceuticals Europe since 2003 46 In 2009 GSK acquired Stiefel Laboratories then the world s largest independent dermatology drug company for US 3 6 billion 47 In November 2009 the FDA approved GSK s vaccine for 2009 H1N1 influenza protection manufactured by the company s ID Biomedical Corp in Canada 48 Also in November 2009 GSK formed a joint venture with Pfizer to create ViiV Healthcare which specializes in HIV research 49 In 2010 the company acquired Laboratorios Phoenix an Argentine pharmaceutical company for US 253m 50 and the UK based sports nutrition company Maxinutrition for 162 million US 256 million 51 2011 2022 edit In 2011 in a US 660 million deal Prestige Brands Holdings took over 17 GSK brands with sales of US 210 million including BC Powder Beano Ecotrin Fiber Choice Goody s Powder Sominex and Tagamet 52 In 2012 the company announced that it would invest 500 million in manufacturing facilities in Ulverston northern England designating it as the site for a previously announced biotech plant 53 In May that year it acquired CellZome a German biotech company for US 98 million 54 and in June worldwide rights to alitretinoin Toctino an eczema drug for US 302 million 55 In 2013 GSK acquired Human Genome Sciences HGS for US 3 billion the companies had collaborated on developing the lupus drug Belimumab Benlysta albiglutide for type 2 diabetes and darapladib for atherosclerosis 56 and in September sold its beverage division to Suntory This included the brands Lucozade and Ribena however the deal did not include Horlicks 57 In March 2014 GSK paid US 1 billion to raise its stake in its Indian pharmaceutical unit GlaxoSmithKline Pharmaceuticals to 75 per cent as part of a move to focus on emerging markets 58 In April 2014 Novartis and Glaxo agreed on more than US 20 billion in deals with Novartis selling its vaccine business to GSK and buying GSK s cancer business 59 60 In February 2015 GSK announced that it would acquire GlycoVaxyn a Swiss pharmaceutical company for US 190 million 61 and in June that year that it would sell two meningitis drugs to Pfizer Nimenrix and Mencevax for around US 130 million 62 Philip Hampton at that time chair of the Royal Bank of Scotland became GSK chairman in September 2015 63 On 31 March 2017 Emma Walmsley became CEO She is the first female CEO of the company 64 65 In December 2017 Reuters reported that Glaxo had increased its stake in its Saudi Arabian unit to 75 from 49 taking over control from its Saudi partner Banaja KSA Holding Company 66 With respect to rare diseases the company divested its portfolio of gene therapy drugs to Orchard Therapeutics in April 2018 67 In November 2018 Reuters reported that Unilever was in prime position to acquire GSK s interest in its Indian unit GlaxoSmithKline Consumer Healthcare Ltd in a sale that could generate around US 4 billion for the company 68 Nestle and Coca Cola have also been reported to be interested in the business unit as they look to strengthen their presence in India 68 69 On 3 December 2018 GSK announced that Unilever would acquire the Indian listed GlaxoSmithKline Consumer Healthcare business for US 3 8 billion 2 98 billion Unilever will pay the majority of the deal in cash with the remaining being paid in shares in its Indian operation Hindustan Unilever Limited Upon completion GSK will then own around 5 7 of Hindustan Unilever Limited selling those shares in a number of tranches 70 The same day the company also announced it would acquire oncology specialist Tesaro for US 5 1 billion The deal will give GSK control of ovarian cancer treatment Zejula a member of the class of poly ADP ribose polymerase PARP inhibitors 71 In October 2019 GSK agreed to sell its rabies vaccine RabAvert and its tick borne encephalitis vaccine Encepur to Bavarian Nordic for US 1 06 billion 955 million 72 73 In July 2020 GSK acquired a 10 stake in German biotech company CureVac 74 GSK Novartis consumer healthcare buy out edit In March 2018 GSK announced that it has reached an agreement with Novartis to acquire Novartis s 36 5 stake in their Consumer Healthcare Joint Venture for US 13 billion 9 2 billion 75 67 GSK Pfizer joint venture edit In December 2018 GSK announced that it along with Pfizer had reached an agreement to merge and combine their consumer healthcare divisions into a single entity The combined entity would have sales of around 9 8 billion 12 7 billion with GSK maintaining a 68 controlling stake in the joint venture Pfizer would own the remaining 32 shareholding The deal builds on an earlier 2018 deal where GSK bought out Novartis stake in the GSK Novartis consumer healthcare joint business 76 Subsequent split edit nbsp Prior logo before 9 June 2022 The culmination of the Consumer Healthcare string of deals will result in GSK splitting into two separate companies via a demerger and subsequent listing of the joint venture This will create two publicly traded companies one focusing on pharmaceuticals and research amp development the other on consumer healthcare On 22 February 2022 GSK announced that the spin off consumer healthcare company will be called Haleon 76 77 In January 2022 the company announced that they had received three unsolicited offers from Unilever to acquire the Consumer Healthcare business unit with the final proposal valuing the business unit at 50 billion 41 7 billion in cash plus 8 3 billion in Unilever shares 78 Subsequently GSK declined all outside offers attempts to acquire its consumer healthcare business and moved forward with its plan to complete the demerger from the main biopharmaceutical business 79 Recent developments edit In April 2022 the business announced it would acquire Sierra Oncology Inc for 1 9 billion 55 per share 80 In May 2022 GSK announced it would acquire Affinivax and its phase II 24 valent pneumococcal vaccine candidate for up to 3 3 billion strengthening its vaccine business 81 On 16 May 2022 the company changed its name from GlaxoSmithKline to GSK 82 In April 2023 GSK announced it would acquire Bellus Health Inc for 2 billion 83 In February 2024 the company acquired Aiolos Bio for over 1 billion adding to its existing asthma business through AIO 001 a long acting monoclonal antibody that targets the thymic stromal lymphopoietin cytokine 84 85 Acquisition history diagram edit GlaxoSmithKline StructureGSK GlaxoSmithKline SmithKline Beecham Plc Renamed 1989 SmithKline Beckman Renamed 1982 SmithKline RIT Renamed 1968 Smith Kline amp French Reorganized 1929 into Smith Kline and French Laboratories French Richards and Company Acquired 1891 Smith Kline and Company Recherche et Industrie Therapeutiques Acquired 1968 Beckman Instruments Inc Merged 1982 Sold 1989 Specialized Instruments Corp Acquired 1954 Offner Electronics Acquired 1961 International Clinical Laboratories Acquired 1989 Reckitt amp Colman Acquired 1999 Beecham Group Plc Merged 1989 Beecham Group Ltd S E Massengill Company Acquired 1971 C L Bencard Acquired 1953 County Chemicals Norcliff Thayer Acquired 1986 Glaxo Wellcome Glaxo Merged 1995 Joseph Nathan amp Co Allen amp Hanburys Founded 1715 acquired 1958 Meyer Laboratories Merged 1978 Affymax Acquired 1995 Wellcome Foundation Renamed 1924 merged 1995 Burroughs Wellcome amp Company Founded 1880 McDougall amp Robertson Inc Acquired 1959 Block Drug Acquired 2001 CNS Inc Acquired 2006 Stiefel Laboratories Acquired 2009 Laboratorios Phoenix Acquired 2010 Maxinutrition Acquired 2010 CellZome Acquired 2011 Human Genome Sciences Acquired 2013 GlycoVaxyn Acquired 2015 Tesaro Acquired 2019 Sitari Pharmaceuticals Acquired 2019 Sierra Oncology Acquired 2022 Affinivax Acquired 2022 Bellus Health Inc Acquired 2023 Aiolos Bio Acquired 2024 Research areas and products editFurther information List of GSK plc products Pharmaceuticals edit GSK manufactures products for major disease areas such as asthma cancer infections diabetes and mental health Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin 86 and amoxicillin clavulanate 87 ticarcillin clavulanate 88 mupirocin 89 and ceftazidime 90 for bacterial infections zidovudine for HIV infection valacyclovir for herpes virus infections albendazole for parasitic infections sumatriptan for migraine lamotrigine for epilepsy bupropion and paroxetine for major depressive disorder cimetidine and ranitidine for gastroesophageal reflux disorder mercaptopurine 91 and thioguanine 92 for the treatment of leukemia allopurinol for gout 93 pyrimethamine for malaria 94 and the antibacterial trimethoprim 92 Among these albendazole amoxicillin amoxicillin clavulanate allopurinol mercaptopurine mupirocin pyrimethamine ranitidine thioguanine trimethoprim and zidovudine are on the World Health Organization s List of Essential Medicines 8 Malaria vaccine edit In 2014 GSK applied for regulatory approval for the first malaria vaccine 7 Malaria is responsible for over 650 000 deaths annually mainly in Africa 95 Known as RTS S the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates Foundation The company has committed to making the vaccine available in developing countries for five per cent above the cost of production 7 As of 2013 update RTS S which uses GSK s proprietary AS01 adjuvant was being examined in a Phase 3 trial in eight African countries PATH reported that i n the 12 month period following vaccination RTS S conferred approximately 50 protection from clinical Plasmodium falciparum disease in children aged 5 17 months and approximately 30 protection in children aged 6 12 weeks when administered in conjunction with Expanded Program for Immunization EPI vaccines 96 In 2014 Glaxo said it had spent more than US 350 million and expected to spend an additional US 260 million before seeking regulatory approval 97 98 Consumer healthcare edit GSK s consumer healthcare division which earned 5 2 billion in 2013 sells oral healthcare including Aquafresh Macleans and Sensodyne toothpastes GSK also previously owned the Lucozade and Ribena brands of soft drinks but they were sold in 2013 to Suntory for 1 35bn 57 Other products include Abreva to treat cold sores Night Nurse a cold remedy Breathe Right nasal strips and Nicoderm and Nicorette nicotine replacements 99 In March 2014 it recalled Alli an over the counter weight loss drug in the United States and Puerto Rico because of possible tampering following customer complaints 100 Facilities edit As of 2013 update GSK had offices in over 115 countries and employed over 99 000 people 12 500 in R amp D The company s single largest market is the United States Its US headquarters are in Philadelphia Pennsylvania and Durham North Carolina its consumer products division is in Moon Township Pennsylvania 101 COVID 19 vaccine edit Main article Sanofi GSK COVID 19 vaccine In July 2020 the UK government signed up for 60 million doses of a COVID 19 vaccine developed by GSK and Sanofi It uses a recombinant protein based technology from Sanofi and GSK s pandemic technology The companies claimed to be able to produce one billion doses subject to successful trials and regulatory approval during the first half of 2021 102 The company also agreed to a 2 1 billion deal with the United States to produce 100 million doses of the vaccine 103 Venture arms editSR One was established in 1985 by SmithKline Beecham to invest in new biotechnology companies and continued operating after GSK was formed by 2003 GSK had formed another subsidiary GSK Ventures to out license or start new companies around drug candidates that it did not intend to develop further 104 As of 2003 update SR One tended to invest only if the company aligned with GSK s business 104 In September 2019 Avalon Ventures announced that it entered into a definitive agreement with GlaxoSmithKline GSK for the acquisition of Sitari Pharmaceuticals by GSK This includes its transglutaminase 2 TG2 small molecule program for the treatment of celiac disease 105 Recognition philanthropy and social responsibility editScientific recognition edit Four GlaxoSmithKline scientists have been recognized by the Nobel Committee for their contributions to basic medical science and or therapeutics development Henry Dale a former student of Paul Ehrlich received the 1936 Nobel Prize in Medicine for his work on the chemical transmission of neural impulses Dale served as a pharmacologist and then as Director of the Wellcome Physiological Research Laboratories from 1904 to 1914 and later served as Trustee and chairman of the board of the Wellcome Trust 106 John Vane of Wellcome Research Laboratories shared the 1982 Nobel Prize for Medicine for his work on prostaglandin biology and the discovery of prostacyclin Vane served as group research and development director for The Wellcome Foundation from 1973 to 1985 107 Gertrude B Elion and George Hitchings both of the Wellcome Research Laboratories shared the 1988 Nobel Prize in Medicine with Sir James W Black formerly of Smith Kline amp French and the Wellcome Foundation for their discoveries of important principles for drug treatment Elion and Hitchings were responsible for the discovery of a plethora of important drugs including mercaptopurine 91 and thioguanine 92 for the treatment of leukemia the immunosuppressant azothioprine 108 allopurinol for gout 93 pyrimethamine for malaria 94 the antibacterial trimethoprim 92 acyclovir for herpes virus infection 109 and nelarabine for cancer treatment 110 Philanthropy and social responsibility edit Since 2010 GlaxoSmithKline has several times ranked first among pharmaceutical companies on the Global Access to Medicines Index which is funded by the Bill and Melinda Gates Foundation 111 In 2014 the Human Rights Campaign an LGBT rights advocacy group gave GSK a score of 100 per cent in its Corporate Equality Index 112 GSK has been active with the World Health Organization WHO in the Global Alliance to Eliminate Lymphatic Filariasis GAELF Around 120 million people globally are believed to be infected with lymphatic filariasis 113 In 2012 the company endorsed the London Declaration on Neglected Tropical Diseases it agreed to donate 400 million albendazole tablets to the WHO each year to fight soil transmitted helminthiasis and to provide 600 million albendazole tablets every year for lymphatic filariasis until the disease is eradicated 114 As of 2014 update over 5 billion treatments had been delivered and 18 of 73 countries in which the disease is considered endemic had progressed to the surveillance stage 115 In 2009 the company said it would cut drug prices by 25 per cent in 50 of the poorest nations release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development and invest 20 per cent of profits from the least developed countries in medical infrastructure for those countries 116 117 Medecins Sans Frontieres welcomed the decision but criticized GSK for failing to include HIV patents in its patent pool and for not including middle income countries in the initiative 118 In 2013 GSK licensed its HIV portfolio to the Medicines Patent Pool for use in children and agreed to negotiate a license for dolutegravir an integrase inhibitor then in clinical development 119 In 2014 this license was extended to include dolutegravir and adults with HIV The licenses include countries in which 93 per cent of adults and 99 per cent of children with HIV live 120 Also in 2013 GSK joined AllTrials a British campaign to ensure that all clinical trials are registered and the results reported The company said it would make its past clinical trial reports available and future ones within a year of the studies end 121 GSK has largely had an access strategy providing medicines at a subsidized price to lower and middle income markets including Africa under the former CEO Andrew Witty In 2017 its new CEO Emma Walmsley 122 shifted away from this with GSK exiting all Sub Saharan African markets and there being no plans to provide its newer expensive oncology and genetics pipeline to this population 123 Controversies edit1973 Antitrust case over griseofulvin edit In the 1960s Glaxo Group Ltd Glaxo and Imperial Chemical Industries ICI each owned patents covering various aspects of the antifungal drug griseofulvin 124 54 nn 1 2 125 They created a patent pool by cross licensing their patents subject to express licensing restrictions that the chemical from which the finished form of the drug tablets and capsules was made must not be resold in bulk form and they licensed other drug companies to sell the drug in finished form and subject to similar restrictions 124 54 55 125 The effect and intent of the bulk sale restriction was to keep the drug chemical out of the hands of small companies that might act as price cutters and the effect was to maintain stable uniform prices 126 127 128 The United States brought an antitrust suit against the two companies United States v Glaxo Group Ltd charging them with violation of the Sherman Act and also seeking to have the patents declared invalid 124 55 125 The trial court found that the defendants had engaged in several unlawful conspiracies but dismissed the part of the suit seeking invalidation of patents and refused to grant as relief mandatory sales of the bulk drug chemical and compulsory licensing of the patents 124 56 125 The government appealed to the Supreme Court which reversed in United States v Glaxo Group Ltd 410 U S 52 1973 125 2000s Ribena edit nbsp nbsp Old Ribena bottle year unknown made by Beecham Products Brentford Middlesex the label states widely used in hospitals and clinics There were concerns in the 2000s about the sugar and vitamin content of Ribena a blackcurrant based syrup and soft drink owned by GSK until 2013 Produced in England by H W Carter amp Co from the 1930s the company s unbranded syrup was distributed to children as a source of vitamin C during World War II which gave the drink a reputation as good for health Beecham bought H W Carter in 1955 129 In 2001 the British Advertising Standards Authority ASA required GSK to withdraw its claim that Ribena Toothkind a lower sugar variety did not encourage tooth decay A company poster showed bottles of Toothkind in place of the bristles on a toothbrush The ASA s ruling was upheld by the High Court 130 In 2007 GSK was fined US 217 000 in New Zealand over its claim that ready to drink Ribena contained high levels of vitamin C after it was found to contain no detectable vitamin C 131 In 2013 GSK sold Ribena and another drink Lucozade to the Japanese multinational Suntory for 1 35 billion 57 SB Pharmco Puerto Rico edit In 2010 the US Department of Justice announced that GSK would pay a US 150 million criminal fine and forfeiture and a civil settlement of US 600 million under the False Claims Act The fines stemmed from production of improperly made and adulterated drugs from 2001 to 2005 at GSK s subsidiary SB Pharmco Puerto Rico Inc in Cidra Puerto Rico which at the time produced US 5 5 billion of products each year The drugs involved were Kytril an antiemetic Bactroban used to treat skin infections Paxil the anti depressant and Avandamet a diabetes drug 132 GSK closed the factory in 2009 133 The case began in 2002 when GSK sent experts to fix problems cited by the FDA The lead inspector recommended recalls of defective products but they were not authorised she was fired in 2003 and filed a whistleblower lawsuit In 2005 federal marshals seized US 2 billion worth of products the largest such seizure in history In the 2010 settlement SB Pharmco pleaded guilty to criminal charges and agreed to pay US 150 million in a criminal fine and forfeiture at that time the largest such payment ever by a manufacturer of adulterated drugs and US 600 million in civil penalties to settle the civil lawsuit 133 2010 Pandemrix connected with narcolepsy edit The Pandemrix influenza vaccine was developed by GlaxoSmithKline in 2006 It was used by Finland and Sweden in the H1N1 mass vaccination of the population against the 2009 swine flu pandemic In August 2010 The Swedish Medical Products Agency MPA and The Finnish National Institute for Health and Welfare THL launched investigations regarding the development of narcolepsy as a possible side effect to Pandemrix flu vaccination in children 134 and found a 6 6 fold increased risk among children and youths resulting in 3 6 additional cases of narcolepsy per 100 000 vaccinated subjects 135 In February 2011 The Finnish National Institute for Health and Welfare THL concluded that there is a clear connection between the Pandemrix vaccination campaign of 2009 and 2010 and the narcolepsy epidemic in Finland A total of 152 cases of narcolepsy were found in Finland during 2009 2010 and ninety per cent of them had received the Pandemrix vaccination 136 137 138 Sweden however observed very few influenza cases totally in 2009 and especially 2010 as compared to most other years 139 In 2015 it was reported that the British Department of Health was paying for Sodium oxybate medication for 80 patients who are taking legal action over problems linked to the use of the swine flu vaccine at a cost to the government of 12 000 per patient per year 140 2012 criminal and civil settlement edit Overview edit In July 2012 GSK pleaded guilty in the United States to criminal charges and agreed to pay US 3 billion in what was the largest settlement until then between the Justice Department and a drug company The US 3 billion included a criminal fine of US 956 814 400 and forfeiture of US 43 185 600 The remaining US 2 billion covered a civil settlement with the government under the False Claims Act The investigation was launched largely on the basis of information from four whistleblowers who filed qui tam whistleblower lawsuits against the company under the False Claims Act 9 The charges stemmed from GSK s promotion of the anti depressants Paxil paroxetine and Wellbutrin bupropion for unapproved uses from 1998 to 2003 specifically as suitable for patients under the age of 18 and from its failure to report safety data about Avandia rosiglitazone both in violation of the Federal Food Drug and Cosmetic Act Other drugs promoted for unapproved uses were two inhalers Advair fluticasone salmeterol and Flovent fluticasone propionate as well as Zofran ondansetron Imitrex sumatriptan Lotronex alosetron and Valtrex valaciclovir 9 The settlement also covered reporting false best prices and underpaying rebates owed under the Medicaid Drug Rebate Program and kickbacks to physicians to prescribe GSK s drugs There were all expenses paid spa treatments and hunting trips for doctors and their spouses speakers fees at conferences and payment for articles ghostwritten by the company and placed by physicians in medical journals 9 The company set up a ghostwriting programme called CASPPER initially to produce articles about Paxil but which was extended to cover Avandia 141 As part of the settlement GSK signed a five year corporate integrity agreement with the Department of Health and Human Services which obliged the company to make major changes in the way it did business including changing its compensation programmes for its sales force and executives and to implement and maintain transparency in its research practices and publication policies 9 It announced in 2013 that it would no longer pay doctors to promote its drugs or attend medical conferences and that its sales staff would no longer have prescription targets 142 Rosiglitazone Avandia edit Further information Rosiglitazone Adverse effects and Rosiglitazone Lawsuits nbsp Rosiglitazone The 2012 settlement included a criminal fine of US 242 612 800 for failing to report safety data to the FDA about Avandia rosiglitazone a diabetes drug approved in 1999 and a civil settlement of US 657 million for making false claims about it The Justice Department said GSK had promoted rosiglitazone to physicians with misleading information including that it conferred cardiovascular benefits despite an FDA mandated label warning of cardiovascular risks 9 In 1999 John Buse a diabetes specialist told medical conferences that rosiglitazone might carry an increased risk of cardiovascular problems GSK threatened to sue him called his university head of department and persuaded him to sign a retraction 143 GSK raised questions internally about the drug s safety in 2000 and in 2002 the company ghostwrote an article in Circulation describing a GSK funded clinical trial that suggested rosiglitazone might have a beneficial effect on cardiovascular risk 144 From 2001 reports began to link the thiazolidinediones the class of drugs to which rosiglitazone belongs to heart failure 145 In April that year GSK began a six year open label randomized trial known as RECORD to examine rosiglitazone and cardiovascular events 146 Two GSK meta analyses in 2005 and 2006 showed an increased risk of cardiovascular problems with rosiglitazone the information was passed to the FDA and posted on the company website but not otherwise published By December 2006 rosiglitazone had become the top selling diabetes drug with annual sales of US 3 3 billion 145 In June 2007 The New England Journal of Medicine published a meta analysis that associated the drug with an increased risk of heart attack 147 GSK had reportedly tried to persuade one of the authors Steven Nissen not to publish it after receiving an advance copy from one of the journal s peer reviewers a GSK consultant 148 149 In July 2007 FDA scientists suggested that rosiglitazone had caused 83 000 excess heart attacks between 1999 and 2007 150 4 151 The FDA placed restrictions on the drug including adding a boxed warning but did not withdraw it 152 In 2013 the FDA rejected that the drug had caused excess heart attacks 153 A Senate Finance Committee inquiry concluded in 2010 that GSK had sought to intimidate scientists who had concerns about rosiglitazone 150 In February that year the company tried to halt publication of an editorial about the controversy by Nissen in the European Heart Journal 154 The results of GSK s RECORD trial were published in June 2009 It confirmed an association between rosiglitazone and an increased risk of heart failure and fractures but not of heart attack and concluded that it does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose lowering drugs 146 Steven Nissan and Kathy Wolkski argued that the study s low event rates reduced its statistical power 155 In September 2009 rosiglitazone was suspended in Europe 156 The results of the RECORD study were confirmed in 2013 by the Duke Clinical Research Institute in an independent review required by the FDA 157 In November that year the FDA lifted the restrictions it had placed on the drug 158 The boxed warning about heart attack was removed the warning about heart failure remained in place 153 Paroxetine Paxil Seroxat edit Main article Study 329 nbsp Paroxetine known as Paxil and Seroxat GSK was fined for promoting Paxil Seroxat paroxetine for treating depression in the under 18s although the drug had not been approved for pediatric use 9 Paxil had US 4 97 billion worldwide sales in 2003 159 The company conducted nine clinical trials between 1994 and 2002 none of which showed that Paxil helped children with depression 160 From 1998 to 2003 it promoted the drug for the under 18s paying physicians to go on all expenses paid trips five star hotels and spas 9 From 2004 Paxil s label along with those of similar drugs included an FDA mandated boxed warning that it might increase the risk of suicidal ideation and behaviour in patients under 18 9 An internal SmithKline Beecham document said in 1998 about withheld data from two GSK studies It would be commercially unacceptable to include a statement that pediatric efficacy had not been demonstrated as this would undermine the profile of paroxetine 159 161 The company ghostwrote an article published in 2001 in the Journal of the American Academy of Child and Adolescent Psychiatry that misreported the results of one of its clinical trials Study 329 9 162 The article concluded that Paxil was generally well tolerated and effective for major depression in adolescents 163 The suppression of the research findings is the subject of the 2008 book Side Effects by Alison Bass 164 165 For 10 years GSK marketed Paxil as non habit forming In 2001 35 patients filed a class action suit alleging they had had withdrawal symptoms and in 2002 a Los Angeles court issued an injunction preventing GSK from advertising that the drug was not habit forming 166 The court withdrew the injunction after the FDA objected that the court had no jurisdiction over drug marketing that the FDA had approved 167 In 2003 a World Health Organization committee reported that Paxil was among the top 30 drugs and top three antidepressants for which dependence had been reported 168 n 2 Bupropion Wellbutrin edit The company was also fined for promoting Wellbutrin bupropion approved at the time for major depressive disorder and also sold as a smoking cessation aid Zyban for weight loss and the treatment of attention deficit hyperactivity disorder sexual dysfunction and substance addiction GSK paid doctors to promote these off label uses and set up supposedly independent advisory boards and Continuing Medical Education programmes 9 China edit Main article GSK China Scandal In 2013 Chinese authorities announced that since 2007 GSK had funnelled HK 3 8 billion in kickbacks to GSK managers doctors hospitals and others who prescribed their drugs using over 700 travel agencies and consulting firms 169 Chinese authorities arrested four GSK executives as part of a four month investigation into claims that doctors were bribed with cash and sexual favours 170 In 2014 a Chinese court found the company guilty of bribery and imposed a fine of US 490 million Mark Reilly the British head of GSK s Chinese operations received a three year suspended prison sentence after a one day trial held in secret 171 Reilly was reportedly deported from China and dismissed by the company 172 Market manipulation in the UK edit In February 2016 the company was fined over 37 million in the UK by the Competition and Markets Authority for paying Generics UK Alpharma and Norton Healthcare more than 50m between 2001 and 2004 to keep generic varieties of paroxetine out of the UK market The generics companies were fined a further 8 million At the end of 2003 when generics became available in the UK the price of paroxetine dropped by 70 per cent 173 Miscellaneous edit Italian police sought bribery charges in May 2004 against 4 400 doctors and 273 GSK employees GSK and its predecessor were accused of having spent 152m on physicians pharmacists and others giving them cameras computers holidays and cash Doctors were alleged to have received cash based on the number of patients they treated with a cancer drug topotecan Hycamtin 174 The following month prosecutors in Munich accused 70 100 doctors of having accepted bribes from SmithKline Beecham between 1997 and 1999 The inquiry was opened over allegations that the company had given over 4 000 hospital doctors money and free trips 175 176 All charges were dismissed by the Verona court in January 2009 177 In 2006 in the United States GSK settled the largest tax dispute in IRS history agreeing to pay US 3 1 billion At issue were Zantac and other products sold in 1989 2005 The case revolved around intracompany transfer pricing determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS 178 179 The UK s Serious Fraud Office SFO opened a criminal inquiry in 2014 into GSK s sales practices using powers granted by the Bribery Act 2010 180 The SFO said it was collaborating with Chinese authorities to investigate bringing charges in the UK related to GSK s activities in China Europe and the Middle East 181 Also as of 2014 update the US Department of Justice was investigating GSK with reference to the Foreign Corrupt Practices Act 182 In October 2020 GSK told some staff that while at work they should disable the contact tracing function of the NHS test and trace app which monitors the spread of COVID 19 GSK explained the reason for this was due to social distancing measures in place at their sites rendering the technology unnecessary 183 See also edit nbsp Companies portal List of toothpaste brands Galvani Bioelectronics Index of oral health and dental articles Recherche et Industrie Therapeutiques R I T 51 29 17 N 0 19 1 W 51 48806 N 0 31694 W 51 48806 0 31694Notes edit Glaxo Wellcome was formed from Glaxo s 1995 acquisition of The Wellcome Foundation and SmithKline Beecham from the 1989 merger of the Beecham Group and the SmithKline Beckman Corporation World Health Organization Expert Committee on Drug Dependence 2003 The Committee noted the striking number of reports on paroxetine and withdrawal syndrome The representative of Consumers International reported that a number of patients had experienced difficulty in withdrawing from SSRIs in general It was agreed that withdrawal was indeed a problem in some patients but there was a 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