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London Declaration on Neglected Tropical Diseases

January 01, 1970

The London Declaration on Neglected Tropical Diseases was a collaborative disease eradication programme launched on 30 January 2012 in London. It was inspired by the World Health Organization roadmap to eradicate or prevent transmission for neglected tropical diseases by the year 2020.[1] Officials from WHO, the World Bank, the Bill & Melinda Gates Foundation, the world's 13 leading pharmaceutical companies, and government representatives from US, UK, United Arab Emirates, Bangladesh, Brazil, Mozambique and Tanzania participated in a joint meeting at the Royal College of Physicians to launch this project. The meeting was spearheaded by Margaret Chan, Director-General of WHO, and Bill Gates, Co-Chair of the Bill & Melinda Gates Foundation.[2][3]

This declaration was the largest coordinated effort to date in health issues and it aimed to eliminate or control 10 neglected diseases by 2020 by providing more than US$785 million to support research and development. These diseases are most rampant in the economically deprived regions of the world and affect 1.4 billion people.[4]

Neglected tropical diseases edit

Main article: Neglected tropical diseases

The rather ambitious commitment is to eradicate or prevent transmission of Guinea worm disease; eliminate lymphatic filariasis, leprosy, African sleeping sickness and blinding trachoma; and to control schistosomiasis, soil-transmitted helminthiasis, Chagas disease, visceral leishmaniasis and river blindness by 2020.[5]

Endorsements edit

Initial partners edit

The original endorsers with their basic strategies were:[6][7]

  1. Abbott: A US-based global pharmaceutical and health care company works for the prevention, diagnosis and treatment of all major neglected diseases. It provides innovative technologies, drug compounds and scientific expertise, academic research and health education.
  2. AstraZeneca: A British-Swedish multinational pharmaceutical and biologics company headquartered in London.
  3. Bayer HealthCare Pharmaceuticals: A division of Germany's pharmaceutical company supports the fight against Chagas disease and African sleeping sickness. The company will specifically make their products nifurtimox and suramin, the drugs of choice for the disease respectively, doubly accessible in South America and Africa, where the diseases are prevalent.
  4. Bill & Melinda Gates Foundation: The foundation has put up a 5-year US$363 million commitment, the largest funding for the project.
  5. Becton Dickinson: An American medical technology company.
  6. Bristol-Myers Squibb: A New York-based pharmaceutical company.
  7. The Children's Investment Fund Foundation: A UK charitable organisation.
  8. Drugs for Neglected Diseases Initiative (DNDi): A global research and development organisation with headquarters at Geneva will actively work for development of new drugs (such as oxaborole, fexinidazole) and perform clinical trials.
  9. Eisai: A Japanese pharmaceutical company with headquarters at Tokyo manufacture and supply Diethylcarbamazine (up to 2.2 billion 100 mg tablets) free of charge to WHO to combat lymphatic filariasis.
  10. Gilead Sciences: A biopharmaceutical company in California that discovers, develops and commercializes therapeutics will donate 445,000 vials of its AmBisome over five years (equivalent to $8 million) for treatment of visceral leishmaniasis.
  11. GlaxoSmithKline: A London-based multinational pharmaceutical and consumer healthcare company headquartered will donate 400 million albendazole tablets each year to fight soil-transmitted helminthiasis. Further it will continue to provide 600 million tablets albendazole per year for lymphatic filariasis as long as necessary until the disease is eliminated.
  12. Johnson & Johnson: An American multinational medical and consumer packaged goods manufacturer will work through its collaborative project Children Without Worms in the dissemination of drugs and providing health education. It will extend its existing donation of mebendazole (200 million tablets per year) for soil-transmitted helminthiasis.
  13. Lions Clubs International: A secular service club in Illinois supports blindness prevention through its SightFirst programme to fight blinding trachoma. The SightFirst has allocated over US$11 million in 10 countries for eye surgeries, medical training, distribution of Zithromax and tetracycline, and sanitary services. It has also announced US$6.9 million funding to support the Government of China.
  14. Merck KGaA: A German chemical and pharmaceutical company will continue to donate praziquantel for schistosomiasis indefinitely. It will increase its annual donation from 25 million tablets at present to 250 million tablets (worth US$23 million per year).
  15. Merck Sharp & Dohme, MSD: An American pharmaceutical company will run Mectizan Donation Program to provide ivermectin for river blindness and lymphatic filariasis.
  16. Mundo Sano: An international non-profit organization based in Argentina to fight against Chagas disease and STHs. It contributed US$5 million for project expansion and program enhancement for selected sites in the Americas and Africa.
  17. Novartis: a Swiss multinational pharmaceutical company based in Basel will extend its commitment to provide multi-drug therapy (rifampicin, clofazimine and dapsone) to eradicate leprosy.
  18. Pfizer: A New York-based American multinational pharmaceutical corporation will continue its donation of azithromycin for blinding trachoma until at least 2020.
  19. Sanofi: A French multinational pharmaceutical company headquartered in Paris will extend its existing donation of eflornithine, melarsoprol and pentamidine for treating sleeping sickness.
  20. USAID: The US federal government agency will continue support to over 20 countries and the U.S. Congress had appropriated $89 million to USAID.
  21. World Bank: An international financial institution will implement the African Programme for Onchocerciasis Control to completely control river blindness.

Other endorsers edit

There were 71 endorsing organisations, including NGOs, academic institutes and companies. As the programme was launched, the governments of Brazil, Tanzania, Bangladesh and Mozambique announced political and financial commitment to the implementation of the programme.[8]

Progress and achievements edit

The annual progress reports on the London Declaration are reported by the organisation, Uniting to Combat Neglected Tropical Diseases. These reports celebrated progress and identified the issues in achieving the aims of the declaration.[9] In 2017, the Uniting to Combat NTDs received the Guinness World Record of "Most medication donated in 24 hours (multiple venues)" for donating 207,169,292 doses of drugs within 24 hours.[10][11]

The programme did not meet complete success, but millions of lives were saved, the burden of the infections was reduced, and 42 countries eliminated at least one disease.[12] An estimated 500 million people became free from treatments against one or more diseases. One of the biggest successes was the control of Guinea worm disease; by 2018, it was eliminated in 19 of 21 countries.[13] As the London Declaration programme ended, only 15 cases were recorded globally.[14] Lymphatic filariasis was eliminated as public health problems in 16 countries, trachoma in 10 countries, and onchocerciasis in four. Annual cases of African trypanosomiasis were reduced from more than 7000 in 2012 to fewer than 1000 in 2018; the number surpassed the projected 2000 cases by 2020. Cases of leprosy has been reduced to 1% in a year.[15]

In 2019, the Government of the United Arab Emirates announced that it will observe 30 January as the World NTD Day. The next year, WHO formally adopted the day to commemorate the launch of both the first NTD road map and the London Declaration.[16][17]

See also edit

References edit

  1. ^ Crompton DWT, ed. (2012). Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases – A Roadmap for Implementation (PDF). Geneva: WHO Press, World Health Organization.
  2. ^ WHO (3 February 2012). . who.int. World Health Organization, Geneva. Archived from the original on April 7, 2014. Retrieved 2013-05-29.
  3. ^ The Pharma Letter (31 January 2012). "Research-based pharma pledges on neglected tropical diseases". thepharmaletter.com. Retrieved 2013-05-29.
  4. ^ Cohen, Joshua P.; Silva, Lisseth; Cohen, Alisa; Awatin, Josephine; Sturgeon, Robert (2016). "Progress Report on Neglected Tropical Disease Drug Donation Programs". Clinical Therapeutics. 38 (5): 1193–1204. doi:10.1016/j.clinthera.2016.02.031. PMID 27041410.
  5. ^ Mitra, Amal K.; Mawson, Anthony R. (2017-08-05). "Neglected Tropical Diseases: Epidemiology and Global Burden". Tropical Medicine and Infectious Disease. 2 (3): 36. doi:10.3390/tropicalmed2030036. ISSN 2414-6366. PMC 6082091. PMID 30270893.
  6. ^ Bill & Melinda Gates Foundation (30 January 2012). . gatesfoundation.org. Press Room, Bill & Melinda Gates Foundation. Archived from the original on 14 March 2013. Retrieved 2013-05-30.
  7. ^ Uniting to Combat NTDs (2012). . unitingtocombatntds.org. Uniting to Combat Neglected Tropical Diseases. Archived from the original on 2013-05-25. Retrieved 2013-05-30.
  8. ^ "Progress in Combating Neglected Tropical Diseases (NTDs): U.S. and Global Efforts from FY2006 to FY2015". www.everycrsreport.com. 2014-05-28. Retrieved 2022-12-28.
  9. ^ "Progress Reports of the London Declaration". Uniting to Combat NTDs. Retrieved 2022-12-28.
  10. ^ "Uniting to Combat NTDs program tackles infectious diseases with new world record". Guinness World Records. 2017-04-19. Retrieved 2023-01-02.
  11. ^ "Uniting to Combat NTDs programme sets record". BusinessGhana. 2017-04-26. Retrieved 2023-01-02.
  12. ^ The Lancet (2022-01-29). "Neglected tropical diseases: ending the neglect of populations". Lancet. 399 (10323): 411. doi:10.1016/S0140-6736(22)00161-1. PMID 35093213.
  13. ^ Hopkins, Donald R.; Ruiz-Tiben, Ernesto; Eberhard, Mark L.; Weiss, Adam; Withers, P. Craig; Roy, Sharon L.; Sienko, Dean G. (2018). "Dracunculiasis Eradication: Are We There Yet?". The American Journal of Tropical Medicine and Hygiene. 99 (2): 388–395. doi:10.4269/ajtmh.18-0204. ISSN 1476-1645. PMC 6090361. PMID 29869608.
  14. ^ Burki, Talha (2022-07-02). "New declaration on neglected tropical diseases endorsed". Lancet. 400 (10345): 15. doi:10.1016/S0140-6736(22)01237-5. PMID 35780782. S2CID 250150750.
  15. ^ Malecela, Mwelecele N.; Ducker, Camilla (2021-01-28). "A road map for neglected tropical diseases 2021-2030". Transactions of the Royal Society of Tropical Medicine and Hygiene. 115 (2): 121–123. doi:10.1093/trstmh/trab002. ISSN 1878-3503. PMC 7842088. PMID 33508095.
  16. ^ Hotez, Peter J.; Aksoy, Serap; Brindley, Paul J.; Kamhawi, Shaden (2020). "World neglected tropical diseases day". PLOS Neglected Tropical Diseases. 14 (1): e0007999. doi:10.1371/journal.pntd.0007999. ISSN 1935-2735. PMC 6988912. PMID 31995572.
  17. ^ Elphick-Pooley, Thoko; Engels, Dirk; Uniting to Combat NTDs (2022-01-28). "World NTD Day 2022 and a new Kigali Declaration to galvanise commitment to end neglected tropical diseases". Infectious Diseases of Poverty. 11 (1): 2. doi:10.1186/s40249-021-00932-2. PMC 8794616. PMID 35086566.

External links edit

  • Official website
  • End the Neglect
  • London Centre for Neglected Tropical Disease Research

January 01, 1970
london, declaration, neglected, tropical, diseases, collaborative, disease, eradication, programme, launched, january, 2012, london, inspired, world, health, organization, roadmap, eradicate, prevent, transmission, neglected, tropical, diseases, year, 2020, of. The London Declaration on Neglected Tropical Diseases was a collaborative disease eradication programme launched on 30 January 2012 in London It was inspired by the World Health Organization roadmap to eradicate or prevent transmission for neglected tropical diseases by the year 2020 1 Officials from WHO the World Bank the Bill amp Melinda Gates Foundation the world s 13 leading pharmaceutical companies and government representatives from US UK United Arab Emirates Bangladesh Brazil Mozambique and Tanzania participated in a joint meeting at the Royal College of Physicians to launch this project The meeting was spearheaded by Margaret Chan Director General of WHO and Bill Gates Co Chair of the Bill amp Melinda Gates Foundation 2 3 This declaration was the largest coordinated effort to date in health issues and it aimed to eliminate or control 10 neglected diseases by 2020 by providing more than US 785 million to support research and development These diseases are most rampant in the economically deprived regions of the world and affect 1 4 billion people 4 Contents 1 Neglected tropical diseases 2 Endorsements 2 1 Initial partners 2 2 Other endorsers 3 Progress and achievements 4 See also 5 References 6 External linksNeglected tropical diseases editMain article Neglected tropical diseases The rather ambitious commitment is to eradicate or prevent transmission of Guinea worm disease eliminate lymphatic filariasis leprosy African sleeping sickness and blinding trachoma and to control schistosomiasis soil transmitted helminthiasis Chagas disease visceral leishmaniasis and river blindness by 2020 5 Endorsements editInitial partners edit The original endorsers with their basic strategies were 6 7 Abbott A US based global pharmaceutical and health care company works for the prevention diagnosis and treatment of all major neglected diseases It provides innovative technologies drug compounds and scientific expertise academic research and health education AstraZeneca A British Swedish multinational pharmaceutical and biologics company headquartered in London Bayer HealthCare Pharmaceuticals A division of Germany s pharmaceutical company supports the fight against Chagas disease and African sleeping sickness The company will specifically make their products nifurtimox and suramin the drugs of choice for the disease respectively doubly accessible in South America and Africa where the diseases are prevalent Bill amp Melinda Gates Foundation The foundation has put up a 5 year US 363 million commitment the largest funding for the project Becton Dickinson An American medical technology company Bristol Myers Squibb A New York based pharmaceutical company The Children s Investment Fund Foundation A UK charitable organisation Drugs for Neglected Diseases Initiative DNDi A global research and development organisation with headquarters at Geneva will actively work for development of new drugs such as oxaborole fexinidazole and perform clinical trials Eisai A Japanese pharmaceutical company with headquarters at Tokyo manufacture and supply Diethylcarbamazine up to 2 2 billion 100 mg tablets free of charge to WHO to combat lymphatic filariasis Gilead Sciences A biopharmaceutical company in California that discovers develops and commercializes therapeutics will donate 445 000 vials of its AmBisome over five years equivalent to 8 million for treatment of visceral leishmaniasis GlaxoSmithKline A London based multinational pharmaceutical and consumer healthcare company headquartered will donate 400 million albendazole tablets each year to fight soil transmitted helminthiasis Further it will continue to provide 600 million tablets albendazole per year for lymphatic filariasis as long as necessary until the disease is eliminated Johnson amp Johnson An American multinational medical and consumer packaged goods manufacturer will work through its collaborative project Children Without Worms in the dissemination of drugs and providing health education It will extend its existing donation of mebendazole 200 million tablets per year for soil transmitted helminthiasis Lions Clubs International A secular service club in Illinois supports blindness prevention through its SightFirst programme to fight blinding trachoma The SightFirst has allocated over US 11 million in 10 countries for eye surgeries medical training distribution of Zithromax and tetracycline and sanitary services It has also announced US 6 9 million funding to support the Government of China Merck KGaA A German chemical and pharmaceutical company will continue to donate praziquantel for schistosomiasis indefinitely It will increase its annual donation from 25 million tablets at present to 250 million tablets worth US 23 million per year Merck Sharp amp Dohme MSD An American pharmaceutical company will run Mectizan Donation Program to provide ivermectin for river blindness and lymphatic filariasis Mundo Sano An international non profit organization based in Argentina to fight against Chagas disease and STHs It contributed US 5 million for project expansion and program enhancement for selected sites in the Americas and Africa Novartis a Swiss multinational pharmaceutical company based in Basel will extend its commitment to provide multi drug therapy rifampicin clofazimine and dapsone to eradicate leprosy Pfizer A New York based American multinational pharmaceutical corporation will continue its donation of azithromycin for blinding trachoma until at least 2020 Sanofi A French multinational pharmaceutical company headquartered in Paris will extend its existing donation of eflornithine melarsoprol and pentamidine for treating sleeping sickness USAID The US federal government agency will continue support to over 20 countries and the U S Congress had appropriated 89 million to USAID World Bank An international financial institution will implement the African Programme for Onchocerciasis Control to completely control river blindness Other endorsers edit There were 71 endorsing organisations including NGOs academic institutes and companies As the programme was launched the governments of Brazil Tanzania Bangladesh and Mozambique announced political and financial commitment to the implementation of the programme 8 Progress and achievements editThe annual progress reports on the London Declaration are reported by the organisation Uniting to Combat Neglected Tropical Diseases These reports celebrated progress and identified the issues in achieving the aims of the declaration 9 In 2017 the Uniting to Combat NTDs received the Guinness World Record of Most medication donated in 24 hours multiple venues for donating 207 169 292 doses of drugs within 24 hours 10 11 The programme did not meet complete success but millions of lives were saved the burden of the infections was reduced and 42 countries eliminated at least one disease 12 An estimated 500 million people became free from treatments against one or more diseases One of the biggest successes was the control of Guinea worm disease by 2018 it was eliminated in 19 of 21 countries 13 As the London Declaration programme ended only 15 cases were recorded globally 14 Lymphatic filariasis was eliminated as public health problems in 16 countries trachoma in 10 countries and onchocerciasis in four Annual cases of African trypanosomiasis were reduced from more than 7000 in 2012 to fewer than 1000 in 2018 the number surpassed the projected 2000 cases by 2020 Cases of leprosy has been reduced to 1 in a year 15 In 2019 the Government of the United Arab Emirates announced that it will observe 30 January as the World NTD Day The next year WHO formally adopted the day to commemorate the launch of both the first NTD road map and the London Declaration 16 17 See also editSanitation Helminthiasis Kigali Declaration on Neglected Tropical DiseasesReferences edit Crompton DWT ed 2012 Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases A Roadmap for Implementation PDF Geneva WHO Press World Health Organization WHO 3 February 2012 WHO roadmap inspires unprecedented support to defeat neglected tropical diseases who int World Health Organization Geneva Archived from the original on April 7 2014 Retrieved 2013 05 29 The Pharma Letter 31 January 2012 Research based pharma pledges on neglected tropical diseases thepharmaletter com Retrieved 2013 05 29 Cohen Joshua P Silva Lisseth Cohen Alisa Awatin Josephine Sturgeon Robert 2016 Progress Report on Neglected Tropical Disease Drug Donation Programs Clinical Therapeutics 38 5 1193 1204 doi 10 1016 j clinthera 2016 02 031 PMID 27041410 Mitra Amal K Mawson Anthony R 2017 08 05 Neglected Tropical Diseases Epidemiology and Global Burden Tropical Medicine and Infectious Disease 2 3 36 doi 10 3390 tropicalmed2030036 ISSN 2414 6366 PMC 6082091 PMID 30270893 Bill amp Melinda Gates Foundation 30 January 2012 Private and Public Partners Unite to Combat 10 Neglected Tropical Diseases by 2020 gatesfoundation org Press Room Bill amp Melinda Gates Foundation Archived from the original on 14 March 2013 Retrieved 2013 05 30 Uniting to Combat NTDs 2012 Endorsements endorsing organizations unitingtocombatntds org Uniting to Combat Neglected Tropical Diseases Archived from the original on 2013 05 25 Retrieved 2013 05 30 Progress in Combating Neglected Tropical Diseases NTDs U S and Global Efforts from FY2006 to FY2015 www everycrsreport com 2014 05 28 Retrieved 2022 12 28 Progress Reports of the London Declaration Uniting to Combat NTDs Retrieved 2022 12 28 Uniting to Combat NTDs program tackles infectious diseases with new world record Guinness World Records 2017 04 19 Retrieved 2023 01 02 Uniting to Combat NTDs programme sets record BusinessGhana 2017 04 26 Retrieved 2023 01 02 The Lancet 2022 01 29 Neglected tropical diseases ending the neglect of populations Lancet 399 10323 411 doi 10 1016 S0140 6736 22 00161 1 PMID 35093213 Hopkins Donald R Ruiz Tiben Ernesto Eberhard Mark L Weiss Adam Withers P Craig Roy Sharon L Sienko Dean G 2018 Dracunculiasis Eradication Are We There Yet The American Journal of Tropical Medicine and Hygiene 99 2 388 395 doi 10 4269 ajtmh 18 0204 ISSN 1476 1645 PMC 6090361 PMID 29869608 Burki Talha 2022 07 02 New declaration on neglected tropical diseases endorsed Lancet 400 10345 15 doi 10 1016 S0140 6736 22 01237 5 PMID 35780782 S2CID 250150750 Malecela Mwelecele N Ducker Camilla 2021 01 28 A road map for neglected tropical diseases 2021 2030 Transactions of the Royal Society of Tropical Medicine and Hygiene 115 2 121 123 doi 10 1093 trstmh trab002 ISSN 1878 3503 PMC 7842088 PMID 33508095 Hotez Peter J Aksoy Serap Brindley Paul J Kamhawi Shaden 2020 World neglected tropical diseases day PLOS Neglected Tropical Diseases 14 1 e0007999 doi 10 1371 journal pntd 0007999 ISSN 1935 2735 PMC 6988912 PMID 31995572 Elphick Pooley Thoko Engels Dirk Uniting to Combat NTDs 2022 01 28 World NTD Day 2022 and a new Kigali Declaration to galvanise commitment to end neglected tropical diseases Infectious Diseases of Poverty 11 1 2 doi 10 1186 s40249 021 00932 2 PMC 8794616 PMID 35086566 External links editOfficial website End the Neglect NTDs at Helen Keller International London Centre for Neglected Tropical Disease Research Retrieved from https en wikipedia org w index php title London Declaration on Neglected Tropical Diseases amp oldid 1188064859, wikipedia, wiki, book, books, library,

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