Diborane

See also: diborane(2) and diborane(4)

Diborane(6), generally known as diborane, is the chemical compound with the formula B₂H₆. It is a toxic, colorless, and pyrophoric gas with a repulsively sweet odor. Diborane is a key boron compound with a variety of applications. It has attracted wide attention for its electronic structure. Several of its derivatives are useful reagents.

Diborane

Names
IUPAC name Diborane(6)
Identifiers
CAS Number	19287-45-7^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:33590^Y
ChemSpider	17215804^Y
ECHA InfoCard	100.039.021
EC Number	242-940-6
PubChem CID	6328200 incorrect structure
RTECS number	HQ9275000
UNII	BS9K982N24
UN number	1911
CompTox Dashboard (EPA)	DTXSID9024938
InChI InChI=1S/B2H6/c1-3-2-4-1/h1-2H2^Y Key: KLDBIFITUCWVCC-UHFFFAOYSA-N^Y InChI=1/B2H6/c1-3-2-4-1/h1-2H2 Key: KLDBIFITUCWVCC-UHFFFAOYAF
SMILES [BH2]1[H][BH2][H]1
Properties
Chemical formula	B2H6
Molar mass	27.67 g·mol^−1
Appearance	Colorless gas
Odor	repulsive and sweet
Density	1.131 g/L^[1]
Melting point	−164.85 °C (−264.73 °F; 108.30 K)^[1]
Boiling point	−92.49 °C (−134.48 °F; 180.66 K)^[1]
Solubility in water	Reacts^[2]
Solubility in other solvents	Diglyme and Diethyl Ether,^[3]
Vapor pressure	39.5 atm (16.6 °C)^[2]
Structure
Coordination geometry	Tetrahedral (for boron)
Molecular shape	see text
Dipole moment	0 D
Thermochemistry
Heat capacity (C)	56.7 J/(mol·K)^[4]
Std molar entropy (S^⦵298)	232.1 J/(mol·K)^[4]
Std enthalpy of formation (ΔfH^⦵298)	36.4 kJ/mol^[4]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	toxic, highly flammable, reacts with water
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H220, H280, H314, H330, H370, H372
Precautionary statements	P210, P260, P264, P270, P271, P280, P284, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P314, P320, P321, P363, P377, P381, P403, P403+P233, P405, P410+P403, P501
NFPA 704 (fire diamond)	^[6] 4 4 3 W
Autoignition temperature	38 °C (100 °F; 311 K)
Explosive limits	0.8–88%^[2]
Lethal dose or concentration (LD, LC):
LC50 (median concentration)	40 ppm (rat, 4 h) 29 ppm (mouse, 4 h) 40–80 ppm (rat, 4 h) 159–181 ppm (rat, 15 min)^[5]
LCLo (lowest published)	125 ppm (dog, 2 h) 50 ppm (hamster, 8 h)^[5]
NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.1 ppm (0.1 mg/m^3)^[2]
REL (Recommended)	TWA 0.1 ppm (0.1 mg/m^3)^[2]
IDLH (Immediate danger)	15 ppm^[2]
Related compounds
Related boron compounds	Decaborane BF3
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references

Structure and bonding

 

Bonding diagram of diborane (B₂H₆) showing with curved lines a pair of three-center two-electron bonds, each of which consists of a pair of electrons bonding three atoms; two boron atoms and a hydrogen atom in the middle

The structure of diborane has D_2h symmetry. Four hydrides are terminal, while two bridge between the boron centers. The lengths of the B–H_bridge bonds and the B–H_terminal bonds are 1.33 and 1.19 Å respectively. This difference in bond lengths reflects the difference in their strengths, the B–H_bridge bonds being relatively weaker. The weakness of the B–H_bridge compared to B–H_terminal bonds is indicated by their vibrational signatures in the infrared spectrum, being ≈2100 and 2500 cm⁻¹ respectively.^[7]

The model determined by molecular orbital theory describes the bonds between boron and the terminal hydrogen atoms as conventional 2-center 2-electron covalent bonds. The bonding between the boron atoms and the bridging hydrogen atoms is, however, different from that in molecules such as hydrocarbons. Each boron uses two electrons in bonding to the terminal hydrogen atoms and has one valence electron remaining for additional bonding. The bridging hydrogen atoms provide one electron each. The B₂H₂ ring is held together by four electrons forming two 3-center 2-electron bonds. This type of bond is sometimes called a "banana bond".

B₂H₆ is isoelectronic with C₂H₆²⁺, which would arise from the diprotonation of the planar molecule ethylene.^[8] Diborane is one of many compounds with such unusual bonding.^[9]

Of the other elements in group IIIA, gallium is known to form a similar compound digallane, Ga₂H₆. Aluminium forms a polymeric hydride, (AlH₃)_n; although unstable, Al₂H₆ has been isolated in solid hydrogen and is isostructural with diborane.^[10]

Production and synthesis

Extensive studies of diborane have led to the development of multiple synthesis routes. Most preparations entail reactions of hydride donors with boron halides or alkoxides. The industrial synthesis of diborane involves the reduction of BF₃ by sodium hydride (NaH), lithium hydride (LiH) or lithium aluminium hydride (LiAlH₄):^[11]

8 BF₃ + 6 LiH → B₂H₆ + 6 LiBF₄

Two laboratory methods start from boron trichloride with lithium aluminium hydride or from boron trifluoride ether solution with sodium borohydride. Both methods result in as much as 30% yield:

4 BCl₃ + 3 LiAlH₄ → 2 B₂H₆ + 3 LiAlCl₄

4 BF₃ + 3 NaBH₄ → 2 B₂H₆ + 3 NaBF₄

Older methods entail the direct reaction of borohydride salts with a non-oxidizing acid, such as phosphoric acid or dilute sulfuric acid.

2 BH₄⁻ + 2 H⁺ → 2 H₂ + B₂H₆

Similarly, oxidation of borohydride salts has been demonstrated and remains convenient for small-scale preparations. For example, using iodine as an oxidizer:

2 NaBH
₄ + I
₂ → 2 NaI + B
₂H
₆ + H
₂

Another small-scale synthesis uses potassium hydroborate and phosphoric acid as starting materials.^[12]

Reactions

 

Borane dimethylsulfide generally functions equivalently to diborane and is easier to use.^[13]

Diborane is a highly reactive and versatile reagent.^[14]

Air, water, oxygen

As a pyrophoric substance, diborane reacts exothermically with oxygen to form boron trioxide and water:

2 B₂H₆ + 6 O₂ → 2 B₂O₃ + 6 H₂O (ΔH_r = −2035 kJ/mol = −73.47 kJ/g)

Diborane reacts violently with water to form hydrogen and boric acid:

B₂H₆ + 6 H₂O → 2 B(OH)₃ + 6 H₂ (ΔH_r = −466 kJ/mol = −16.82 kJ/g)

Diborane also reacts with alcohols similarly. Methanol for example give hydrogen and trimethylborate:^[15]

B₂H₆ + 6 MeOH → 2 B(OMe)₃ + 6 H₂

Lewis acidity

One dominating reaction pattern involves formation of adducts with Lewis bases. Often such initial adducts proceed rapidly to give other products. For example, borane-tetrahydrofuran, which often behaves as an equivalently to diborane, degrades to borate esters. Its adduct with dimethyl sulfide is an important reagent in organic synthesis.

With ammonia diborane forms the diammoniate of diborane, DADB with small quantities of ammonia borane as byproduct. The ratio depends on the conditions.

Hydroboration

In the hydroboration reaction, diborane also reacts readily with alkenes to form trialkylboranes. This reaction pattern is rather general and the resulting alkyl borates can be readily derivatized, e.g. to alcohols. Although early work on hydroboration relied on diborane, it has been replaced by borane dimethylsulfide, which is more safely handled.

Other

Pyrolysis of diborane gives hydrogen and diverse boron hydride clusters. For example, pentaborane was first prepared by pyrolysis of diborane at about 200 °C.^[16][17] Although this pyrolysis route is rarely employed, it ushered in a large research theme of borane cluster chemistry.

Treating diborane with sodium amalgam gives NaBH₄ and Na[B₃H₈]^[15] When diborane is treated with lithium hydride in diethyl ether, lithium borohydride is formed:^[15]

B₂H₆ + 2 LiH → 2 LiBH₄

Diborane reacts with anhydrous hydrogen chloride or hydrogen bromide gas to give a boron halohydride:^[15]

B₂H₆ + HX → B₂H₅X + H₂ (X = Cl, Br)

Treating diborane with carbon monoxide at 470 K and 20 bar gives H₃BCO.^[15]

Reagent in organic synthesis

Diborane and its variants are central organic synthesis reagents for hydroboration. Alkenes add across the B–H bonds to give trialkylboranes, which can be further elaborated.^[18] Diborane is used as a reducing agent roughly complementary to the reactivity of lithium aluminium hydride. The compound readily reduces carboxylic acids to the corresponding alcohols, whereas ketones react only sluggishly.

History

Diborane was first synthesised in the 19th century by hydrolysis of metal borides, but it was never analysed. From 1912 to 1936, Alfred Stock, the major pioneer in the chemistry of boron hydrides, undertook his research that led to the methods for the synthesis and handling of the highly reactive, volatile, and often toxic boron hydrides. He proposed the first ethane-like structure of diborane.^[19] Electron diffraction measurements by S. H. Bauer initially appeared to support his proposed structure.^[20][21]

Because of a personal communication with L. Pauling (who supported the ethane-like structure), H. I. Schlessinger and A. B. Burg did not specifically discuss 3-center 2-electron bonding in their then classic review in the early 1940s.^[22] The review does, however, discuss the bridged D_2h structure in some depth: "It is to be recognized that this formulation easily accounts for many of the chemical properties of diborane..."

In 1943, H. Christopher Longuet-Higgins, while still an undergraduate at Oxford, was the first to explain the structure and bonding of the boron hydrides. The article reporting the work, written with his tutor R. P. Bell,^[23] also reviews the history of the subject beginning with the work of Dilthey.^[24] Shortly afterwards, the theoretical work of Longuet-Higgins was confirmed in an infrared study of diborane by Price. ^[25] The structure was re-confirmed by electron-diffraction measurement in 1951 by K. Hedberg and V. Schomaker, with the confirmation of the structure shown in the schemes on this page.^[26]

William Nunn Lipscomb Jr. further confirmed the molecular structure of boranes using X-ray crystallography in the 1950s and developed theories to explain their bonding. Later, he applied the same methods to related problems, including the structure of carboranes, on which he directed the research of future 1981 Nobel Prize winner Roald Hoffmann. The 1976 Nobel Prize in Chemistry was awarded to Lipscomb "for his studies on the structure of boranes illuminating problems of chemical bonding".^[27]

Traditionally, diborane has often been described as electron-deficient, because the 12 valence electrons can only form 6 conventional 2-centre 2-electron bonds, which are insufficient to join all 8 atoms.^[28][29] However, the more correct description using 3-centre bonds shows that diborane is really electron-precise, since there are just enough valence electrons to fill the 6 bonding molecular orbitals.^[30] Nevertheless, some leading textbooks still use the term "electron-deficient".^[31]

Other uses

Because of the exothermicity of its reaction with oxygen, diborane has been tested as a rocket propellant.^[32] Complete combustion is strongly exothermic. However, combustion is not complete in the rocket engine, as some boron monoxide, B₂O, is produced. This conversion mirrors the incomplete combustion of hydrocarbons, to produce carbon monoxide (CO). Diborane also proved difficult to handle.^[33][34][35]

Diborane has been investigated as a precursor to metal boride films^[36] and for the p-doping of silicon semiconductors.^[37]

Safety

Diborane is a pyrophoric gas. Commercially available adducts are typically used instead, at least for applications in organic chemistry. These adducts include borane-tetrahydrofuran (borane-THF) and borane-dimethylsulfide.^[14] The toxic effects of diborane are mitigated because the compound is so unstable in air. The toxicity toward laboratory rats has been investigated.^[38]

References

1. Haynes, p. 4.52.
2. NIOSH Pocket Guide to Chemical Hazards. "#0183". National Institute for Occupational Safety and Health (NIOSH).
3. Yerazunis, S., et al. “Solubility of Diborane in the Dimethyl Ether and Diethylene Glycol, in Mixtures of Sodium Borohydride and Dimethyl Ether of Diethylene Glycol, and in Ditertiary Butyl Sulfide.” Journal of Chemical & Engineering Data, vol. 7, no. 3, July 1962, pp. 337–39, doi:10.1021/je60014a004.
4. Haynes, p. 5.6.
5. "Diborane". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
6. "DIBORANE – CAMEO Chemicals - Chemical Datasheet - Database of Hazardous Materials – NOAA". Retrieved 2022-10-26.
7. Cooper, C. B., III; Shriver, D. F.; Onaka, S. (1978). "Ch. 17. Vibrational spectroscopy of hydride-bridged transition metal compounds". Transition Metal Hydrides. Advances in Chemistry. Vol. 167. pp. 232–247. doi:10.1021/ba-1978-0167.ch017. ISBN 9780841203907.{{cite book}}: CS1 maint: multiple names: authors list (link)
8. Rasul, G.; Prakash, G. K. S.; Olah, G. A. (2005). "Comparative ab initio Study of the Structures and Stabilities of the Ethane Dication C₂H₆²⁺ and Its Silicon Analogues Si₂H₆²⁺ and CSiH₆²⁺". Journal of Physical Chemistry A. 109 (5): 798–801. Bibcode:2005JPCA..109..798R. doi:10.1021/jp0404652. PMID 16838949.
9. Laszlo, P. (2000). "A Diborane Story". Angewandte Chemie International Edition. 39 (12): 2071–2072. doi:10.1002/1521-3773(20000616)39:12<2071::AID-ANIE2071>3.0.CO;2-C. PMID 10941018.
10. Andrews, L.; Wang, X. (2003). "The Infrared Spectrum of Al₂H₆ in Solid Hydrogen". Science. 299 (5615): 2049–2052. Bibcode:2003Sci...299.2049A. doi:10.1126/science.1082456. PMID 12663923. S2CID 45856199.
11. Brauer, Georg (1963). Handbook of Preparative Inorganic Chemistry. Vol. 1 (2nd ed.). New York: Academic Press. p. 773. ISBN 978-0121266011.
12. Norman, A. D.; Jolly, W. L.; Saturnino, D.; Shore, S. G. (1968). Diborane. Inorganic Syntheses. Vol. 11. pp. 15–19. doi:10.1002/9780470132425.ch4. ISBN 9780470132425.
13. Hutchins, Robert O.; Cistone, Frank (1981). "Utility and Applications of Borane Dimethylsulfide in Organic Synthesis. A Review". Organic Preparations and Procedures International. 13 (3–4): 225. doi:10.1080/00304948109356130.
14. Mikhailov, B. M. (1962). "The Chemistry of Diborane". Russian Chemical Reviews. 31 (4): 207–224. Bibcode:1962RuCRv..31..207M. doi:10.1070/RC1962v031n04ABEH001281. S2CID 250909492.
15. Housecroft, C. E.; Sharpe, A. G. (2008). "Chapter 13: The Group 13 Elements". Inorganic Chemistry (3rd ed.). Pearson. p. 336. ISBN 978-0-13-175553-6.
16. Stock, A. (1933). The Hydrides of Boron and Silicon. New York: Cornell University Press. ISBN 0-8014-0412-6.
17. Miller, V. R.; Ryschkewitsch, G. E. (1974). Pentaborane(9) (B₅H₉). Inorganic Syntheses. Vol. 15. pp. 118–122. doi:10.1002/9780470132463.ch26. ISBN 9780470132463.
18. Lane, Clinton F. (1976). "Reduction of organic compounds with diborane". Chemical Reviews. 76 (6): 773–799. doi:10.1021/cr60304a005.
19. Stock, A. (1933). The Hydrides of Boron and Silicon. New York: Cornell University Press.
20. Bauer, S. H. (1937). "The Structure of Diborane". Journal of the American Chemical Society. 59 (6): 1096–1103. doi:10.1021/ja01285a041.
21. Bauer, S. H. (1942). "Structures and Physical Properties of the Hydrides of Boron and of their Derivatives". Chemical Reviews. 31 (1): 43–75. doi:10.1021/cr60098a002.
22. Schlesinger, H. I.; Burg, A. B. (1942). "Recent Developments in the Chemistry of the Boron Hydrides". Chemical Reviews. 31 (1): 1–41. doi:10.1021/cr60098a001.
23. Longuet-Higgins, H. C.; Bell, R. P. (1943). "64. The Structure of the Boron Hydrides". Journal of the Chemical Society (Resumed). 1943: 250–255. doi:10.1039/JR9430000250.
24. Dilthey, W. (1921). "Über die Konstitution des Wassers". Angewandte Chemie. 34 (95): 596. doi:10.1002/ange.19210349509.
25. Price, W. C. (1948). "The absorption spectrum of diborane". J. Chem. Phys. 16 (9): 894. Bibcode:1948JChPh..16..894P. doi:10.1063/1.1747028.
26. Hedberg, K.; Schomaker, V. (1951). "A Reinvestigation of the Structures of Diborane and Ethane by Electron Diffraction". Journal of the American Chemical Society. 73 (4): 1482–1487. doi:10.1021/ja01148a022.
27. "The Nobel Prize in Chemistry 1976". Nobelprize.org. Retrieved 2012-02-01.
28. Longuet-Higgins, H. C. (1957). "The structures of electron-deficient molecules". Quarterly Reviews, Chemical Society. 11 (2): 121–133. doi:10.1039/qr9571100121. Retrieved 15 July 2020.
29. Murrell, J. N.; Kettle, S. F. A.; Tedder, J. M. (1965). Valence theory. John Wiley and Sons. p. 243.
30. Lipscomb, William N. (11 December 1976). "The Boranes and their relatives (Nobel lecture)" (PDF). nobelprize.org. Nobel Foundation. pp. 224–245. Retrieved 16 July 2020. One of the simple consequences of these studies was that electron deficient molecules, defined as having more valence orbitals than electrons, are not really electron deficient.
31. Housecroft, Catherine E.; Sharpe, Alan G. (2005). Inorganic Chemistry (2nd ed.). Pearson Prentice-Hall. p. 326. ISBN 0130-39913-2. An electron-deficient species possesses fewer valence electrons than are required for a localized bonding scheme.
32. Bilstein, Roger. "Stages to Saturn". chapter 5: NASA Public Affairs Office. p. 133. Retrieved 14 November 2015.{{cite web}}: CS1 maint: location (link)
33. Gammon, Benson E.; Genco, Russell S.; Gerstein, Melvin (1950). A preliminary experimental and analytical evaluation of diborane as a ram-jet fuel (PDF). National Advisory Committee for Aeronautics.
34. Tower, Leonard K.; Breitwieser, Roland; Gammon, Benson E. (1958). Theoretical Combustion Performance of Several High-Energy Fuels for Ramjet Engines (PDF). National Advisory Committee for Aeronautics.
35. "LIQUID HYDROGEN AS A PROPULSION FUEL, 1945–1959. Part II: 1950–1957. Chapter 5. NACA Research on High-Energy Propellants". history.nasa.gov.
36. Brotherton, Robert J.; Weber, C. Joseph; Guibert, Clarence R.; Little, John L. (2000). Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a04_309.
37. Mehta, Bhavesh; Tao, Meng (2005). "A Kinetic Model for Boron and Phosphorus Doping in Silicon Epitaxy by CVD". Journal of the Electrochemical Society. 152 (4): G309. Bibcode:2005JElS..152G.309M. doi:10.1149/1.1864452.
38. Nomiyama, Tetsuo; Omae, Kazuyuki; Ishizuka, Chizuru; Hosoda, Kanae; Yamano, Yuko; Nakashima, Hiroshi; Uemura, Takamoto; Sakurai, Haruhiko (1996). "Evaluation of the Subacute Pulmonary and Testicular Inhalation Toxicity of Diborane in Rats". Toxicology and Applied Pharmacology. 138 (1): 77–83. doi:10.1006/taap.1996.0100. PMID 8658516.

Cited sources

• Haynes, William M., ed. (2011). CRC Handbook of Chemistry and Physics (92nd ed.). CRC Press. ISBN 978-1439855119.
• Yerazunis, S., et al. “Solubility of Diborane in the Dimethyl Ether and Diethylene Glycol, in Mixtures of Sodium Borohydride and Dimethyl Ether of Diethylene Glycol, and in Ditertiary Butyl Sulfide.” Journal of Chemical & Engineering Data, vol. 7, no. 3, July 1962, pp. 337–39, doi:10.1021/je60014a004.

External links

• International Chemical Safety Card 0432
• NIOSH Pocket Guide to Chemical Hazards
• U.S. EPA Acute Exposure Guideline Levels