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Haplogroup Q-M120

January 01, 1970

Haplogroup Q-M120, also known as Q1a1a1, is a Y-DNA haplogroup. It is the only primary branch of haplogroup Q1a1a (F746/NWT01). The lineage is most common amongst modern populations in eastern Eurasia.

Haplogroup Q-M120
Possible time of origin15 400 ybp
Possible place of originAsia
AncestorQ1a1a (F746/NWT01)
Defining mutationsM120 and M265 (AKA N14)

Distribution edit

The Americas edit

One of the 1K Genomes samples, HG01944, from Peruvians in Lima, Peru belongs to Q-M120.[1][2] Q-M120 is the other branch under Q-F746. It is best known as an East Asian branch of Q. This is intriguing; if it is not a result of post-colonial admixture, it will mark a fourth or fifth Q lineage in the Americas. The branch of Q-M120 including this sample has a calculated TMRCA of 5,000 to 7,000 years,[1] meaning that it may be the result of a later pre-Columbian immigration from North or East Asia.

Asia edit

Q-M120 is present in Eastern Asia and may trace its origin to East Asia.[3][4][5] It has been found at low frequency in samples of Han Chinese,[4][5] Dungans,[6] Hmong Daw in Laos,[7] Japanese,[8] Dörwöd Kalmyks,[9] Koreans,[6] Mongols,[10][11] Tibetans,[5][12][13] Uygurs,[14] and Vietnamese.[1][2] It also has been found among Bhutanese,[15] Murut people in Brunei,[16] and Azerbaijanis.[1] Sengupta et al. (2006) reported finding Q-M120 in the HGDP sample of Pakistani Hazaras,[17] but the Bayesian tree in Supplementary Figure 12 of Lippold et al. (2014) suggests that these HGDP Pakistani Hazara individuals more likely should belong to Q-L275, and that three members of the HGDP Naxi sample and one member of the HGDP Han sample should belong to Q-M120 instead.[18] Di Cristofaro et al. (2013) tested the same sample of Pakistani Hazaras and reported that they belonged to the following Y-DNA haplogroups: 1/25 C-PK2/M386(xM407, M532), 9/25 C-M401, 1/25 I-M223, 1/25 J-M530, 2/25 O-M122(xM134), 1/25 Q-M242(xM120, M25, M346, M378), 1/25 Q-M378, 1/25 R-M124, 8/25 R-M478/M73.[11]

Population Paper N Percentage SNP Tested
Dungan (Kyrgyzstan) Wells 2001[6] 3/40 ~7.5% M120
Han (Henan) Su 2000[5] 2/28 ~7.1% M120
Han (Anhui) Su 2000[5] 1/22 ~4.6% M120
Northern Han Su 2000[5] 1/22 ~4.5% M120
Kinh
(Ho Chi Minh City)		 Poznik 2016[2] 2/46 ~4.3% M120
Han (Shanghai) Su 2000[5] 1/30 ~3.3% M120
Han (Shandong) Su 2000[5] 1/32 ~3.1% M120
Korea Wells 2001[6] 1/45 ~2.2% M120
Tibetan (Lhasa) Su 2000[5] 1/46 ~2.2% M120
Tibet Gayden 2007[12] 2/156 ~1.3% M120
Han (Shanxi) Zhong 2010[14] 1/56 ~1.8% M120
Uygur (Xinjiang) Zhong 2010[14] 1/71 ~1.4% M120
Uygur (Xinjiang) Zhong 2010[14] 1/50 ~2.0% M120
Han (Jiangsu) Su 2000[5] 1/55 ~1.8% M120
Mongolia Di Cristofaro 2013[11] 2/160 ~1.25% M120
Japan Nonaka 2007[8] 1/263 ~0.38% M120

Europe edit

To date, Q-M120 has not been detected in European populations.

Associated SNPs edit

Haplogroup Q-M120 is defined by the presence of the M120 Single Nucleotide Polymorphism (SNP) as well as the M265 (AKA N14) SNP.

Phylogenetic tree edit

This is Thomas Krahn at the Genomic Research Center's for haplogroup Q-M120.

  • Q-MEH2 MEH2, L472, L528
    • Q-M120 M120, N14/M265

See also edit

Y-DNA Q-M242 subclades edit

Y-DNA backbone tree edit

References edit

  1. ^ a b c d YFull Haplogroup YTree v6.03.05 at 20 July 2018. Accessed July 20, 2018.
  2. ^ a b c G. David Poznik, Yali Xue, Fernando L. Mendez, et al. (2016), "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences." Nature Genetics 2016 June ; 48(6): 593–599. doi:10.1038/ng.3559.
  3. ^ Grugni, Viola; Raveane, Alessandro; Ongaro, Linda; Battaglia, Vincenza; Trombetta, Beniamino; Colombo, Giulia; Capodiferro, Marco Rosario; Olivieri, Anna; Achilli, Alessandro; Perego, Ugo A.; Motta, Jorge; Tribaldos, Maribel; Woodward, Scott R.; Ferretti, Luca; Cruciani, Fulvio (2019). "Analysis of the human Y-chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas". BMC Biology. 17 (1): 3. doi:10.1186/s12915-018-0622-4. ISSN 1741-7007. PMC 6345020. PMID 30674303.
  4. ^ a b Wen B; Li H; Lu D; et al. (September 2004). "Genetic evidence supports demic diffusion of Han culture". Nature. 431 (7006): 302–5. Bibcode:2004Natur.431..302W. doi:10.1038/nature02878. PMID 15372031. S2CID 4301581. – Supplementary Table 2: NRY haplogroup distribution in Han populations
  5. ^ a b c d e f g h i j Su, Bing; Xiao, Chunjie; Deka, Ranjan; Seielstad, Mark T.; Kangwanpong, Daoroong; Xiao, Junhua; Lu, Daru; Underhill, Peter; Cavalli-Sforza, Luca (2000). "Y chromosome haplotypes reveal prehistorical migrations to the Himalayas". Human Genetics. 107 (6): 582–90. doi:10.1007/s004390000406. PMID 11153912. S2CID 36788262.
  6. ^ a b c d Wells RS; Yuldasheva N; Ruzibakiev R; et al. (August 2001). "The Eurasian Heartland: A continental perspective on Y-chromosome diversity". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10244–9. Bibcode:2001PNAS...9810244W. doi:10.1073/pnas.171305098. PMC 56946. PMID 11526236. – Table 1: Y-chromosome haplotype frequencies in 49 Eurasian populations, listed according to geographic region
  7. ^ Cai X, Qin Z, Wen B, Xu S, Wang Y, et al. (2011), "Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes." PLoS ONE 6(8): e24282. doi:10.1371/journal.pone.0024282
  8. ^ a b Nonaka, I.; Minaguchi, K.; Takezaki, N. (2007). "Y-chromosomal Binary Haplogroups in the Japanese Population and their Relationship to 16 Y-STR Polymorphisms". Annals of Human Genetics. 71 (4): 480–95. doi:10.1111/j.1469-1809.2006.00343.x. hdl:10130/491. PMID 17274803. S2CID 1041367.
  9. ^ Boris Malyarchuk, Miroslava Derenko, Galina Denisova, Sanj Khoyt, Marcin Woźniak, Tomasz Grzybowski, and Ilya Zakharov, "Y-chromosome diversity in the Kalmyks at the ethnical and tribal levels." Journal of Human Genetics (2013) 58, 804–811; doi:10.1038/jhg.2013.108
  10. ^ Battaglia V, Grugni V, Perego UA, Angerhofer N, Gomez-Palmieri JE, et al. (2013), "The First Peopling of South America: New Evidence from Y-Chromosome Haplogroup Q." PLoS ONE 8(8): e71390. doi:10.1371/journal.pone.0071390
  11. ^ a b c Di Cristofaro J, Pennarun E, Mazières S, Myres NM, Lin AA, et al. (2013) "Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge." PLoS ONE 8(10): e76748. doi:10.1371/journal.pone.0076748
  12. ^ a b Gayden T; Cadenas AM; Regueiro M; et al. (May 2007). "The Himalayas as a Directional Barrier to Gene Flow". Am. J. Hum. Genet. 80 (5): 884–94. doi:10.1086/516757. PMC 1852741. PMID 17436243.
  13. ^ Wang C-C, Wang L-X, Shrestha R, Zhang M, Huang X-Y, et al. (2014), "Genetic Structure of Qiangic Populations Residing in the Western Sichuan Corridor." PLoS ONE 9(8): e103772. doi:10.1371/journal.pone.0103772
  14. ^ a b c d Zhong, H.; Shi, H.; Qi, X.-B.; Duan, Z.-Y.; Tan, P.-P.; Jin, L.; Su, B.; Ma, R. Z. (2010). "Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route". Molecular Biology and Evolution. 28 (1): 717–27. doi:10.1093/molbev/msq247. PMID 20837606.
  15. ^ Pille Hallast, Chiara Batini, Daniel Zadik, et al., "The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades." Molecular Biology and Evolution Advance Access publication December 2, 2014. doi:10.1093/molbev/msu327
  16. ^ Monika Karmin, Lauri Saag, Mário Vicente, et al. (2015), "A recent bottleneck of Y chromosome diversity coincides with a global change in culture." Genome Research 25:1–8. Published by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/15; www.genome.org.
  17. ^ Sengupta, Sanghamitra; Zhivotovsky, Lev A.; King, Roy; Mehdi, S.Q.; Edmonds, Christopher A.; Chow, Cheryl-Emiliane T.; Lin, Alice A.; Mitra, Mitashree; Sil, Samir K. (2006). "Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists". The American Journal of Human Genetics. 78 (2): 202–21. doi:10.1086/499411. PMC 1380230. PMID 16400607.
  18. ^ Sebastian Lippold, Hongyang Xu, Albert Ko, Mingkun Li, Gabriel Renaud, Anne Butthof, Roland Schröder, and Mark Stoneking, "Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences." Investigative Genetics 2014, 5:13. http://www.investigativegenetics.com/content/5/1/13

External links edit

  • The Y-DNA Haplogroup Q Project

January 01, 1970
haplogroup, m120, also, known, q1a1a1, haplogroup, only, primary, branch, haplogroup, q1a1a, f746, nwt01, lineage, most, common, amongst, modern, populations, eastern, eurasia, possible, time, origin15, ybppossible, place, originasiaancestorq1a1a, f746, nwt01,. Haplogroup Q M120 also known as Q1a1a1 is a Y DNA haplogroup It is the only primary branch of haplogroup Q1a1a F746 NWT01 The lineage is most common amongst modern populations in eastern Eurasia Haplogroup Q M120Possible time of origin15 400 ybpPossible place of originAsiaAncestorQ1a1a F746 NWT01 Defining mutationsM120 and M265 AKA N14 Contents 1 Distribution 1 1 The Americas 1 2 Asia 1 3 Europe 2 Associated SNPs 3 Phylogenetic tree 4 See also 4 1 Y DNA Q M242 subclades 4 2 Y DNA backbone tree 5 References 6 External linksDistribution editThe Americas edit One of the 1K Genomes samples HG01944 from Peruvians in Lima Peru belongs to Q M120 1 2 Q M120 is the other branch under Q F746 It is best known as an East Asian branch of Q This is intriguing if it is not a result of post colonial admixture it will mark a fourth or fifth Q lineage in the Americas The branch of Q M120 including this sample has a calculated TMRCA of 5 000 to 7 000 years 1 meaning that it may be the result of a later pre Columbian immigration from North or East Asia Asia edit Q M120 is present in Eastern Asia and may trace its origin to East Asia 3 4 5 It has been found at low frequency in samples of Han Chinese 4 5 Dungans 6 Hmong Daw in Laos 7 Japanese 8 Dorwod Kalmyks 9 Koreans 6 Mongols 10 11 Tibetans 5 12 13 Uygurs 14 and Vietnamese 1 2 It also has been found among Bhutanese 15 Murut people in Brunei 16 and Azerbaijanis 1 Sengupta et al 2006 reported finding Q M120 in the HGDP sample of Pakistani Hazaras 17 but the Bayesian tree in Supplementary Figure 12 of Lippold et al 2014 suggests that these HGDP Pakistani Hazara individuals more likely should belong to Q L275 and that three members of the HGDP Naxi sample and one member of the HGDP Han sample should belong to Q M120 instead 18 Di Cristofaro et al 2013 tested the same sample of Pakistani Hazaras and reported that they belonged to the following Y DNA haplogroups 1 25 C PK2 M386 xM407 M532 9 25 C M401 1 25 I M223 1 25 J M530 2 25 O M122 xM134 1 25 Q M242 xM120 M25 M346 M378 1 25 Q M378 1 25 R M124 8 25 R M478 M73 11 Population Paper N Percentage SNP Tested Dungan Kyrgyzstan Wells 2001 6 3 40 7 5 M120 Han Henan Su 2000 5 2 28 7 1 M120 Han Anhui Su 2000 5 1 22 4 6 M120 Northern Han Su 2000 5 1 22 4 5 M120 Kinh Ho Chi Minh City Poznik 2016 2 2 46 4 3 M120 Han Shanghai Su 2000 5 1 30 3 3 M120 Han Shandong Su 2000 5 1 32 3 1 M120 Korea Wells 2001 6 1 45 2 2 M120 Tibetan Lhasa Su 2000 5 1 46 2 2 M120 Tibet Gayden 2007 12 2 156 1 3 M120 Han Shanxi Zhong 2010 14 1 56 1 8 M120 Uygur Xinjiang Zhong 2010 14 1 71 1 4 M120 Uygur Xinjiang Zhong 2010 14 1 50 2 0 M120 Han Jiangsu Su 2000 5 1 55 1 8 M120 Mongolia Di Cristofaro 2013 11 2 160 1 25 M120 Japan Nonaka 2007 8 1 263 0 38 M120 Europe edit To date Q M120 has not been detected in European populations Associated SNPs editHaplogroup Q M120 is defined by the presence of the M120 Single Nucleotide Polymorphism SNP as well as the M265 AKA N14 SNP Phylogenetic tree editThis is Thomas Krahn at the Genomic Research Center s Draft Tree for haplogroup Q M120 Q MEH2 MEH2 L472 L528 Q M120 M120 N14 M265See also editHuman Y chromosome DNA haplogroup Y DNA Q M242 subclades edit Q M242 Q L275 Q L330 Q L717 Q L940 Q L53 Q L54 Q M120 Q M25 Q M3 Q M323 Q M346 Q NWT01 Q P89 1 Q Z780 Y DNA backbone tree editReferences edit a b c d YFull Haplogroup YTree v6 03 05 at 20 July 2018 Accessed July 20 2018 a b c G David Poznik Yali Xue Fernando L Mendez et al 2016 Punctuated bursts in human male demography inferred from 1 244 worldwide Y chromosome sequences Nature Genetics 2016 June 48 6 593 599 doi 10 1038 ng 3559 Grugni Viola Raveane Alessandro Ongaro Linda Battaglia Vincenza Trombetta Beniamino Colombo Giulia Capodiferro Marco Rosario Olivieri Anna Achilli Alessandro Perego Ugo A Motta Jorge Tribaldos Maribel Woodward Scott R Ferretti Luca Cruciani Fulvio 2019 Analysis of the human Y chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas BMC Biology 17 1 3 doi 10 1186 s12915 018 0622 4 ISSN 1741 7007 PMC 6345020 PMID 30674303 a b Wen B Li H Lu D et al September 2004 Genetic evidence supports demic diffusion of Han culture Nature 431 7006 302 5 Bibcode 2004Natur 431 302W doi 10 1038 nature02878 PMID 15372031 S2CID 4301581 Supplementary Table 2 NRY haplogroup distribution in Han populations a b c d e f g h i j Su Bing Xiao Chunjie Deka Ranjan Seielstad Mark T Kangwanpong Daoroong Xiao Junhua Lu Daru Underhill Peter Cavalli Sforza Luca 2000 Y chromosome haplotypes reveal prehistorical migrations to the Himalayas Human Genetics 107 6 582 90 doi 10 1007 s004390000406 PMID 11153912 S2CID 36788262 a b c d Wells RS Yuldasheva N Ruzibakiev R et al August 2001 The Eurasian Heartland A continental perspective on Y chromosome diversity Proc Natl Acad Sci U S A 98 18 10244 9 Bibcode 2001PNAS 9810244W doi 10 1073 pnas 171305098 PMC 56946 PMID 11526236 Table 1 Y chromosome haplotype frequencies in 49 Eurasian populations listed according to geographic region Cai X Qin Z Wen B Xu S Wang Y et al 2011 Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes PLoS ONE 6 8 e24282 doi 10 1371 journal pone 0024282 a b Nonaka I Minaguchi K Takezaki N 2007 Y chromosomal Binary Haplogroups in the Japanese Population and their Relationship to 16 Y STR Polymorphisms Annals of Human Genetics 71 4 480 95 doi 10 1111 j 1469 1809 2006 00343 x hdl 10130 491 PMID 17274803 S2CID 1041367 Boris Malyarchuk Miroslava Derenko Galina Denisova Sanj Khoyt Marcin Wozniak Tomasz Grzybowski and Ilya Zakharov Y chromosome diversity in the Kalmyks at the ethnical and tribal levels Journal of Human Genetics 2013 58 804 811 doi 10 1038 jhg 2013 108 Battaglia V Grugni V Perego UA Angerhofer N Gomez Palmieri JE et al 2013 The First Peopling of South America New Evidence from Y Chromosome Haplogroup Q PLoS ONE 8 8 e71390 doi 10 1371 journal pone 0071390 a b c Di Cristofaro J Pennarun E Mazieres S Myres NM Lin AA et al 2013 Afghan Hindu Kush Where Eurasian Sub Continent Gene Flows Converge PLoS ONE 8 10 e76748 doi 10 1371 journal pone 0076748 a b Gayden T Cadenas AM Regueiro M et al May 2007 The Himalayas as a Directional Barrier to Gene Flow Am J Hum Genet 80 5 884 94 doi 10 1086 516757 PMC 1852741 PMID 17436243 Wang C C Wang L X Shrestha R Zhang M Huang X Y et al 2014 Genetic Structure of Qiangic Populations Residing in the Western Sichuan Corridor PLoS ONE 9 8 e103772 doi 10 1371 journal pone 0103772 a b c d Zhong H Shi H Qi X B Duan Z Y Tan P P Jin L Su B Ma R Z 2010 Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route Molecular Biology and Evolution 28 1 717 27 doi 10 1093 molbev msq247 PMID 20837606 Pille Hallast Chiara Batini Daniel Zadik et al The Y chromosome tree bursts into leaf 13 000 high confidence SNPs covering the majority of known clades Molecular Biology and Evolution Advance Access publication December 2 2014 doi 10 1093 molbev msu327 Monika Karmin Lauri Saag Mario Vicente et al 2015 A recent bottleneck of Y chromosome diversity coincides with a global change in culture Genome Research 25 1 8 Published by Cold Spring Harbor Laboratory Press ISSN 1088 9051 15 www genome org Sengupta Sanghamitra Zhivotovsky Lev A King Roy Mehdi S Q Edmonds Christopher A Chow Cheryl Emiliane T Lin Alice A Mitra Mitashree Sil Samir K 2006 Polarity and Temporality of High Resolution Y Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists The American Journal of Human Genetics 78 2 202 21 doi 10 1086 499411 PMC 1380230 PMID 16400607 Sebastian Lippold Hongyang Xu Albert Ko Mingkun Li Gabriel Renaud Anne Butthof Roland Schroder and Mark Stoneking Human paternal and maternal demographic histories insights from high resolution Y chromosome and mtDNA sequences Investigative Genetics 2014 5 13 http www investigativegenetics com content 5 1 13External links editThe Y DNA Haplogroup Q Project Retrieved from https en wikipedia org w index php title Haplogroup Q M120 amp oldid 1217622911, wikipedia, wiki, book, books, library,

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