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GSK plc

May 04, 2023

Coordinates: 51°29′17″N 0°19′01″W / 51.4881°N 0.3169°W / 51.4881; -0.3169

GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England.[3][4] Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham,[n 1] GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck.[5]

GSK plc
Logo since 9 June 2022
Head office in Brentford, London with the former GlaxoSmithKline logo, taken on 30 July 2007
FormerlyGlaxoSmithKline (2000–2022)
TypePublic limited company
Industry
Predecessors
  • Glaxo Wellcome
  • SmithKline Beecham
Founded27 December 2000; 22 years ago (2000-12-27)
HeadquartersLondon, England, UK
Area served
Worldwide
Key people
Products
Revenue £29.324 billion (2022)
£6.433 billion (2022)
£15.621 billion (2022)
Total assets £60.146 billion (2022)
Total equity £10.096 billion (2022)
Number of employees
70,000 (2022)
Subsidiaries
Websitewww.gsk.com
Footnotes / references
[1][2]

The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. As of August 2022, it had a market capitalisation of £70 billion, the eighth largest on the London Stock Exchange.[6] It has a secondary listing on the New York Stock Exchange.

The company developed the first malaria vaccine, RTS,S, which it said in 2014, it would make available for five percent above cost.[7] Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such as amoxicillin, mercaptopurine, pyrimethamine and zidovudine.[8]

In 2012, under prosecution by the United States Department of Justice (DoJ) based on combined investigations of the Department of Health and Human Services (HHS-OIG), FDA and FBI, primarily concerning sales and marketing of the drugs Avandia, Paxil and Wellbutrin, GSK pleaded guilty to promotion of drugs for unapproved uses, failure to report safety data and kickbacks to physicians in the United States and agreed to pay a US$3 billion (£1.9bn) settlement. It was the largest health-care fraud case to date in the US and the largest settlement by a drug company.[9]

History

Glaxo Wellcome

 
The Glaxo factory built in 1918, in Bunnythorpe, New Zealand, with the Glaxo Laboratories sign still visible

Glaxo

Joseph Nathan and Co. was founded in 1873, as a general trading company in Wellington, New Zealand, by a Londoner, Joseph Edward Nathan.[10] In 1904, it began producing a dried-milk baby food from excess milk produced on dairy farms near Bunnythorpe. The resulting product was first known as Defiance, then as Glaxo (from lacto), and sold with the slogan "Glaxo builds bonnie babies."[11][12]: 306 [13] The Glaxo Laboratories sign is still visible (right) on what is now a car repair shop on the main street of Bunnythorpe. The company's first pharmaceutical product, released in 1924, was vitamin D.[12]: 306 

 
Feeder bottle with valve and teat, Glaxo Laboratories, Greenford, Middlesex

Glaxo Laboratories was incorporated as a distinct subsidiary company in London in 1935.[14] Joseph Nathan's shareholders reorganised the group's structure in 1947, making Glaxo the parent[15] and obtained a listing on the London Stock Exchange.[16] Glaxo acquired Allen & Hanburys in 1958. The Scottish pharmacologist David Jack was hired as a researcher for Allen & Hanburys a few years after Glaxo took it over; he went on to lead the company's research and development (R&D) until 1987.[12]: 306  After Glaxo bought Meyer Laboratories in 1978, it began to play an important role in the US market. In 1983, the American arm, Glaxo Inc., moved to Research Triangle Park (US headquarters/research) and Zebulon (US manufacturing) in North Carolina.[13]

Burroughs Wellcome

Burroughs Wellcome & Company was founded in 1880, in London by the American pharmacists Henry Wellcome and Silas Burroughs. The Wellcome Tropical Research Laboratories opened in 1902. In the 1920s, Burroughs Wellcome established research and manufacturing facilities in Tuckahoe, New York,[17]: 18 [18][19] which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1971.[20][21] The Nobel Prize winning scientists Gertrude B. Elion and George H. Hitchings worked there and invented drugs still used many years later, such as mercaptopurine.[22] In 1959, the Wellcome Foundation bought Cooper, McDougall & Robertson Inc to become more active in animal health.[13]

When Burroughs Wellcome decided to move its headquarters, the company selected Paul Rudolph to design its new building. The Elion-Hitchings Building "was celebrated worldwide when it was built," according to Paul Rudolph Heritage Foundation president Kelvin Dickinson. Alex Sayf Cummings of Georgia State University wrote in 2016, that the "iconic building helped define the image of RTP," saying, "Love it or hate it, Rudolph's design remains an impressively audacious creative gesture and an important part of the history of both architecture and Research Triangle Park."[23] United Therapeutics, which bought the building in 2012, announced plans in 2020, to tear it down.[23]

Merger

Glaxo and Wellcome merged in 1995, to form Glaxo Wellcome plc.[24][12] Glaxo Wellcome restructured its R&D operation that year, cutting 10,000 jobs worldwide, closing its R&D facility in Beckenham, Kent, and opening a Medicines Research Centre in Stevenage, Hertfordshire.[25][26][27] Also that year, Glaxo Wellcome acquired the California-based Affymax, a leader in the field of combinatorial chemistry.[28]

By 1999, Glaxo Wellcome had become the world's third-largest pharmaceutical company by revenues (behind Novartis and Merck), with a global market share of around 4 per cent.[29] Its products included Imigran (for the treatment of migraine), salbutamol (Ventolin) (for the treatment of asthma), Zovirax (for the treatment of coldsores), and Retrovir and Epivir (for the treatment of AIDS). In 1999, the company was the world's largest manufacturer of drugs for the treatment of asthma and HIV/AIDS.[30] It employed 59,000 people, including 13,400 in the UK, had 76 operating companies and 50 manufacturing facilities worldwide, and seven of its products were among the world's top 50 best-selling pharmaceuticals. The company had R&D facilities in Hertfordshire, Kent, London and Verona (Italy), and manufacturing plants in Scotland and the north of England. It had R&D centres in the US and Japan, and production facilities in the US, Europe and the Far East.[31]

SmithKline Beecham

Beecham

Main article: Beecham Group
 
Beecham's Clock Tower, constructed 1877, part of the Beecham's factory, St Helens

In 1848, Thomas Beecham launched his Beecham's Pills laxative in England, giving birth to the Beecham Group. In 1859, Beecham opened its first factory in St Helens, Lancashire. By the 1960s, Beecham was extensively involved in pharmaceuticals and consumer products such as Macleans toothpaste, Lucozade and synthetic penicillin research.[13][32]

SmithKline

Main article: SmithKline & French

John K. Smith opened his first pharmacy in Philadelphia in 1830. In 1865, Mahlon Kline joined the business, which 10 years later became Smith, Kline & Co. In 1891, it merged with French, Richard and Company, and in 1929, changed its name to Smith Kline & French Laboratories as it focused more on research. Years later it bought Norden Laboratories, a business doing research into animal health, and Recherche et Industrie Thérapeutiques in Belgium in 1963, to focus on vaccines. The company began to expand globally, buying seven laboratories in Canada and the United States in 1969. In 1982, it bought Allergan, a manufacturer of eye and skincare products.[13]

Smith Kline & French merged with Beckman Inc. in 1982, and changed its name to SmithKline Beckman.[33] In 1988, it bought International Clinical Laboratories.[34]

Merger

In 1989, SmithKline Beckman merged with Beecham Group to form SmithKline Beecham P.L.C..[35] The headquarters moved from the United States to England. To expand R&D in the United States, the company bought a new research center in 1995; another opened in 1997, in England at New Frontiers Science Park, Harlow.[13]

2000: Glaxo Wellcome and SmithKline Beecham merger

Glaxo Wellcome and SmithKline Beecham announced their intention to merge in January 2000. The merger was completed on 27 December that year, forming GlaxoSmithKline (GSK).[36][37] The company's global headquarters are at GSK House, Brentford, London, officially opened in 2002, by then-Prime Minister Tony Blair. The building was erected at a cost of £300 million and as of 2002 was home to 3,000 administrative staff.[38]

2001–2010

 
Andrew Witty, GSK's CEO from May 2008, to April 2017

GSK completed the acquisition of New Jersey-based Block Drug in 2001, for US$1.24 billion.[39] In 2006, GSK acquired the US-based consumer healthcare company CNS Inc., whose products included Breathe Right nasal strips and FiberChoice dietary supplements, for US$566 million in cash.[40]

Chris Gent, previously CEO of Vodafone, was appointed chairman of the board in 2005.[41] GSK opened its first R&D centre in China in 2007, in Shanghai, initially focused on neurodegenerative diseases.[42] Andrew Witty became the chief executive officer in 2008.[43] Witty joined Glaxo in 1985, and had been president of GSK's Pharmaceuticals Europe since 2003.[44]

In 2009, GSK acquired Stiefel Laboratories, then the world's largest independent dermatology drug company, for US$3.6 billion.[45] In November 2009, the FDA approved GSK's vaccine for 2009 H1N1 influenza protection, manufactured by the company's ID Biomedical Corp in Canada.[46] Also in November 2009, GSK formed a joint venture with Pfizer to create ViiV Healthcare, which specializes in HIV research.[47] In 2010, the company acquired Laboratorios Phoenix, an Argentine pharmaceutical company, for US$253m,[48] and the UK-based sports nutrition company Maxinutrition for £162 million (US$256 million).[49]

2011–2022

In 2011, in a US$660-million deal, Prestige Brands Holdings took over 17 GSK brands with sales of US$210 million, including BC Powder, Beano, Ecotrin, Fiber Choice, Goody's Powder, Sominex and Tagamet.[50] In 2012, the company announced that it would invest £500 million in manufacturing facilities in Ulverston, northern England, designating it as the site for a previously announced biotech plant.[51] In May that year it acquired CellZome, a German biotech company, for US$98 million,[52] and in June, worldwide rights to alitretinoin (Toctino), an eczema drug, for US$302 million.[53] In 2013, GSK acquired Human Genome Sciences (HGS) for US$3 billion; the companies had collaborated on developing the lupus drug Belimumab (Benlysta), albiglutide for type 2 diabetes, and darapladib for atherosclerosis,[54] and in September, sold its beverage division to Suntory. This included the brands Lucozade and Ribena; however, the deal did not include Horlicks.[55]

In March 2014, GSK paid US$1 billion to raise its stake in its Indian pharmaceutical unit, GlaxoSmithKline Pharmaceuticals, to 75 percent as part of a move to focus on emerging markets.[56] In April 2014, Novartis and Glaxo agreed on more than US$20 billion in deals, with Novartis selling its vaccine business to GSK and buying GSK's cancer business.[57][58] In February 2015, GSK announced that it would acquire GlycoVaxyn, a Swiss pharmaceutical company, for US$190 million,[59] and in June that year that it would sell two meningitis drugs to Pfizer, Nimenrix and Mencevax for around US$130 million.[60]

Philip Hampton, at that time chair of the Royal Bank of Scotland, became GSK chairman in September 2015.[61]

On 31 March 2017, Emma Walmsley became CEO. She is the first female CEO of the company.[62][63]

In December 2017, Reuters reported that Glaxo had increased its stake in its Saudi Arabian unit to 75% (from 49%) taking over control from its Saudi partner Banaja KSA Holding Company.[64]

With respect to rare diseases, the company divested its portfolio of gene therapy drugs to Orchard Therapeutics in April 2018.[65] In November 2018, Reuters reported that Unilever was in prime position to acquire GSK's interest in its Indian unit, GlaxoSmithKline Consumer Healthcare Ltd, in a sale that could generate around US$4 billion for the company.[66] Nestlé and Coca-Cola have also been reported to be interested in the business unit as they look to strengthen their presence in India.[66][67] On 3 December 2018, GSK announced that Unilever would acquire the Indian-listed GlaxoSmithKline Consumer Healthcare business for US$3.8 billion (£2.98 billion). Unilever will pay the majority of the deal in cash, with the remaining being paid in shares in its Indian operation, Hindustan Unilever Limited. Upon completion, GSK will then own around 5.7% of Hindustan Unilever Limited, selling those shares in a number of tranches.[68] The same day, the company also announced it would acquire oncology specialist, Tesaro, for US$5.1 billion. The deal will give GSK control of ovarian cancer treatment, Zejula - a member of the class of poly ADP ribose polymerase (PARP) inhibitors.[69]

In October 2019, GSK agreed to sell its rabies vaccine, RabAvert, and its tick-borne encephalitis vaccine, Encepur, to Bavarian Nordic for US$1.06 billion (€955 million).[70][71]

In July 2020, GSK acquired a 10% stake in German biotech company CureVac.[72]

GSK–Novartis consumer healthcare buy-out

In March 2018, GSK announced that it has reached an agreement with Novartis to acquire Novartis's 36.5% stake in their Consumer Healthcare Joint Venture for US$13 billion (£9.2 billion).[73][65]

GSK–Pfizer joint venture

In December 2018, GSK announced that it, along with Pfizer, had reached an agreement to merge and combine their consumer healthcare divisions into a single entity. The combined entity would have sales of around £9.8 billion ($12.7 billion), with GSK maintaining a 68% controlling stake in the joint venture. Pfizer would own the remaining 32% shareholding. The deal builds on an earlier 2018 deal where GSK bought out Novartis' stake in the GSK-Novartis consumer healthcare joint business.[74]

Subsequent split

 
GSK's former logo, used until 9 June 2022

The culmination of the Consumer Healthcare string of deals will result in GSK splitting into two separate companies, via a demerger and subsequent listing of the joint venture. This will create two publicly traded companies, one focusing on pharmaceuticals and research & development, the other on consumer healthcare. On 22 February 2022, GSK announced that the spin-off consumer healthcare company will be called Haleon.[74][75]

In January 2022, the company announced that they had received three unsolicited offers from Unilever to acquire the Consumer Healthcare business unit, with the final proposal valuing the business unit at £50 billion (£41.7 billion in cash, plus £8.3 billion in Unilever shares).[76]

Subsequently, GSK declined all outside offers/attempts to acquire its consumer healthcare business and moved forward with its plan to complete the demerger from the main biopharmaceutical business.[77]

Recent developments

In April 2022, the business announced it would acquire Sierra Oncology Inc for $1.9 billion ($55 per share).[78] In May 2022, GSK announced it would acquire Affinivax and its phase II 24-valent pneumococcal vaccine candidate for up to $3.3 billion, strengthening its vaccine business.[79]

On 16 May 2022, the company changed its name from GlaxoSmithKline to GSK.[80]

In April 2023, GSK announced it would acquire BELLUS Health Inc. for $2.0 billion.[81]

Acquisition-history diagram

GlaxoSmithKline Structure
  • GSK
    • GlaxoSmithKline
      • SmithKline Beecham Plc (Renamed 1989)
        • SmithKline Beckman (Renamed 1982)
          • SmithKline-RIT (Renamed 1968)
          • Beckman Instruments, Inc. (Merged 1982, Sold 1989)
            • Specialized Instruments Corp. (Acquired 1954)
            • Offner Electronics (Acquired 1961)
          • International Clinical Laboratories (Acquired 1989)
          • Reckitt & Colman (Acquired 1999)
        • Beecham Group Plc (Merged 1989)
          • Beecham Group Ltd
          • Norcliff Thayer (Acquired 1986)
      • Glaxo Wellcome
        • Glaxo (Merged 1995)
          • Joseph Nathan & Co
          • Allen & Hanburys (Founded 1715, acquired 1958)
          • Meyer Laboratories (Merged 1978)
          • Affymax (Acquired 1995)
        • Wellcome Foundation (Renamed 1924, merged 1995)
          • Burroughs Wellcome & Company (Founded 1880)
          • McDougall & Robertson Inc (Acquired 1959)
    • Block Drug (Acquired 2001)
    • CNS Inc. (Acquired 2006)
    • Stiefel Laboratories (Acquired 2009)
    • Laboratorios Phoenix (Acquired 2010)
    • Maxinutrition (Acquired 2010)
    • CellZome (Acquired 2011)
    • Human Genome Sciences (Acquired 2013)
    • GlycoVaxyn (Acquired 2015)
    • Tesaro (Acquired 2019)
    • Sitari Pharmaceuticals (Acquired 2019)
    • Sierra Oncology (Acquired 2022)
    • Affinivax (Acquired 2022)
    • BELLUS Health Inc.(Acquired 2023)

Research areas and products

Further information: List of GSK plc products

Pharmaceuticals

GSK manufactures products for major disease areas such as asthma, cancer, infections, diabetes, and mental health. Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin[82] and amoxicillin-clavulanate,[83] ticarcillin-clavulanate,[84] mupirocin,[85] and ceftazidime[86] for bacterial infections, zidovudine for HIV infection, valacyclovir for herpes virus infections, albendazole for parasitic infections, sumatriptan for migraine, lamotrigine for epilepsy, bupropion and paroxetine for major depressive disorder, cimetidine and ranitidine for gastroesophageal reflux disorder, mercaptopurine[87] and thioguanine[88] for the treatment of leukemia, allopurinol for gout,[89] pyrimethamine for malaria,[90] and the antibacterial trimethoprim.[88]

Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupirocin, pyrimethamine, ranitidine, thioguanine, trimethoprim, and zidovudine are on the World Health Organization's List of Essential Medicines.[8]

Malaria vaccine

In 2014, GSK applied for regulatory approval for the first malaria vaccine.[7] Malaria is responsible for over 650,000 deaths annually, mainly in Africa.[91] Known as RTS,S, the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates Foundation. The company has committed to making the vaccine available in developing countries for five percent above the cost of production.[7]

As of 2013, RTS,S, which uses GSK's proprietary AS01 adjuvant, was being examined in a Phase 3 trial in eight African countries. PATH reported that "[i]n the 12-month period following vaccination, RTS,S conferred approximately 50% protection from clinical Plasmodium falciparum disease in children aged 5-17 months, and approximately 30% protection in children aged 6-12 weeks when administered in conjunction with Expanded Program for Immunization (EPI) vaccines."[92] In 2014, Glaxo said it had spent more than US$350 million and expected to spend an additional US$260 million before seeking regulatory approval.[93][94]

Consumer healthcare

GSK's consumer healthcare division, which earned £5.2 billion in 2013, sells oral healthcare, including Aquafresh, Macleans and Sensodyne toothpastes. GSK also previously owned the Lucozade and Ribena brands of soft drinks, but they were sold in 2013, to Suntory for £1.35bn.[55] Other products include Abreva to treat cold sores; Night Nurse, a cold remedy; Breathe Right nasal strips; and Nicoderm and Nicorette nicotine replacements.[95] In March 2014, it recalled Alli, an over-the-counter weight-loss drug, in the United States and Puerto Rico because of possible tampering, following customer complaints.[96]

Facilities

As of 2013, GSK had offices in over 115 countries and employed over 99,000 people, 12,500 in R&D. The company's single largest market is the United States. Its US headquarters are in The Navy Yard, Philadelphia, and Research Triangle Park, North Carolina; its consumer-products division is in Moon Township, Pennsylvania.[97]

COVID-19 vaccine

Main article: Sanofi–GSK COVID-19 vaccine

In July 2020, the UK government signed up for 60 million doses of a COVID-19 vaccine developed by GSK and Sanofi. It uses a recombinant protein-based technology from Sanofi and GSK's pandemic technology. The companies claimed to be able to produce one billion doses, subject to successful trials and regulatory approval, during the first half of 2021.[98] The company also agreed to a $2.1 billion deal with the United States to produce 100 million doses of the vaccine.[99]

Venture arms

SR One was established in 1985, by SmithKline Beecham to invest in new biotechnology companies and continued operating after GSK was formed; by 2003, GSK had formed another subsidiary, GSK Ventures, to out-license or start new companies around drug candidates that it did not intend to develop further.[100] As of 2003, SR One tended to invest only if the company aligned with GSK's business.[100]

In September 2019, GSK announced it would acquire Sitari Pharmaceuticals and its transglutaminase 2 small molecule program for the treatment of celiac disease.[101]

Recognition, philanthropy and social responsibility

Scientific recognition

Four GlaxoSmithKline scientists have been recognized by the Nobel Committee for their contributions to basic medical science and/or therapeutics development.

  • Henry Dale, a former student of Paul Ehrlich, received the 1936 Nobel Prize in Medicine for his work on the chemical transmission of neural impulses. Dale served as a pharmacologist and then as Director of the Wellcome Physiological Research Laboratories from 1904 to 1914, and later served as Trustee and chairman of the board of the Wellcome Trust.[102]
  • John Vane of Wellcome Research Laboratories shared the 1982 Nobel Prize for Medicine for his work on prostaglandin biology and the discovery of prostacyclin. Vane served as group research and development director for The Wellcome Foundation from 1973 to 1985.[103]
  • Gertrude B. Elion and George Hitchings, both of the Wellcome Research Laboratories, shared the 1988 Nobel Prize in Medicine with Sir James W. Black, formerly of Smith Kline & French and the Wellcome Foundation, ""for their discoveries of important principles for drug treatment"." Elion and Hitchings were responsible for the discovery of a plethora of important drugs, including mercaptopurine[87] and thioguanine[88] for the treatment of leukemia, the immunosuppressant azothioprine,[104] allopurinol for gout,[89] pyrimethamine for malaria,[90] the antibacterial trimethoprim,[88] acyclovir for herpes virus infection,[105] and nelarabine for cancer treatment.[106]

Philanthropy and social responsibility

Since 2010, GlaxoSmithKline has several times ranked first among pharmaceutical companies on the Global Access to Medicines Index, which is funded by the Bill and Melinda Gates Foundation.[107] In 2014, the Human Rights Campaign, an LGBT-rights advocacy group gave GSK a score of 100 percent in its Corporate Equality Index.[108]

GSK has been active, with the World Health Organization (WHO), in the Global Alliance to Eliminate Lymphatic Filariasis (GAELF). Around 120 million people globally are believed to be infected with lymphatic filariasis.[109] In 2012, the company endorsed the London Declaration on Neglected Tropical Diseases; it agreed to donate 400 million albendazole tablets to the WHO each year to fight soil-transmitted helminthiasis and to provide 600 million albendazole tablets every year for lymphatic filariasis until the disease is eradicated.[110] As of 2014, over 5 billion treatments had been delivered, and 18 of 73 countries in which the disease is considered endemic had progressed to the surveillance stage.[111]

In 2009, the company said it would cut drug prices by 25 percent in 50 of the poorest nations, release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development, and invest 20 percent of profits from the least-developed countries in medical infrastructure for those countries.[112][113] Médecins Sans Frontières welcomed the decision, but criticized GSK for failing to include HIV patents in its patent pool and for not including middle-income countries in the initiative.[114]

In 2013, GSK licensed its HIV portfolio to the Medicines Patent Pool for use in children, and agreed to negotiate a license for dolutegravir, an integrase inhibitor then in clinical development.[115] In 2014, this license was extended to include dolutegravir and adults with HIV. The licenses include countries in which 93 percent of adults and 99 percent of children with HIV live.[116] Also in 2013 GSK joined AllTrials, a British campaign to ensure that all clinical trials are registered and the results reported. The company said it would make its past clinical-trial reports available and future ones within a year of the studies' end.[117]

GSK has largely had an access strategy, providing medicines at a subsidized price to lower and middle income markets including Africa under the former CEO Andrew Witty. In 2017, its new CEO, Emma Walmsley,[118] shifted away from this with GSK exiting all Sub-Saharan African markets and there being no plans to provide its newer expensive oncology and genetics pipeline to this population.[119]

Controversies

1973 Antitrust case over griseofulvin

In the 1960s, Glaxo Group Ltd. (Glaxo) and Imperial Chemical Industries (ICI) each owned patents covering various aspects of the antifungal drug griseofulvin.[120]: 54, nn. 1–2 [121] They created a patent pool by cross-licensing their patents, subject to express licensing restrictions that the chemical from which the "finished" form of the drug (tablets and capsules) was made must not be resold in bulk form, and they licensed other drug companies to sell the drug in finished form and subject to similar restrictions.[120]: 54–55 [121] The effect and intent of the bulk-sale restriction was to keep the drug chemical out of the hands of small companies that might act as price-cutters, and the effect was to maintain stable, uniform prices.[122][123][124]

The United States brought an antitrust suit against the two companies—United States v. Glaxo Group Ltd.—charging them with violation of the Sherman Act and also seeking to have the patents declared invalid.[120]: 55 [121] The trial court found that the defendants had engaged in several unlawful conspiracies, but dismissed the part of the suit seeking invalidation of patents and refused to grant as relief mandatory sales of the bulk drug chemical and compulsory licensing of the patents.[120]: 56 [121] The government appealed to the Supreme Court, which reversed, in United States v. Glaxo Group Ltd., 410 U.S. 52 (1973).[121]

2000s Ribena

 
 
Old Ribena bottle, year unknown, made by Beecham Products, Brentford, Middlesex; the label states: "widely used in hospitals and clinics."

There were concerns in the 2000s about the sugar and vitamin content of Ribena, a blackcurrant-based syrup and soft drink owned by GSK until 2013. Produced in England by H.W. Carter & Co from the 1930s, the company's unbranded syrup was distributed to children as a source of vitamin C during World War II, which gave the drink a reputation as good for health. Beecham bought H. W. Carter in 1955.[125]

In 2001, the British Advertising Standards Authority (ASA) required GSK to withdraw its claim that Ribena Toothkind, a lower-sugar variety, did not encourage tooth decay. A company poster showed bottles of Toothkind in place of the bristles on a toothbrush. The ASA's ruling was upheld by the High Court.[126] In 2007, GSK was fined US$217,000 in New Zealand over its claim that ready-to-drink Ribena contained high levels of vitamin C, after it was found to contain no detectable vitamin C.[127] In 2013, GSK sold Ribena and another drink, Lucozade, to the Japanese multinational Suntory for £1.35 billion.[55]

SB Pharmco Puerto Rico

In 2010, the US Department of Justice announced that GSK would pay a US$150 million criminal fine and forfeiture, and a civil settlement of US$600 million under the False Claims Act. The fines stemmed from production of improperly made and adulterated drugs from 2001 to 2005, at GSK's subsidiary, SB Pharmco Puerto Rico Inc., in Cidra, Puerto Rico, which at the time produced US$5.5 billion of products each year. The drugs involved were Kytril, an antiemetic; Bactroban, used to treat skin infections; Paxil, the anti-depressant; and Avandamet, a diabetes drug.[128] GSK closed the factory in 2009.[129]

The case began in 2002, when GSK sent experts to fix problems cited by the FDA. The lead inspector recommended recalls of defective products, but they were not authorised; she was fired in 2003, and filed a whistleblower lawsuit. In 2005, federal marshals seized US$2 billion worth of products, the largest such seizure in history. In the 2010 settlement SB Pharmco pleaded guilty to criminal charges, and agreed to pay US$150 million in a criminal fine and forfeiture, at that time the largest such payment ever by a manufacturer of adulterated drugs, and US$600 million in civil penalties to settle the civil lawsuit.[129]

2010 Pandemrix connected with narcolepsy

The Pandemrix influenza vaccine was developed by GlaxoSmithKlinefIn in 2006. It was used by Finland and Sweden in the H1N1 mass vaccination of the population against the 2009 swine flu pandemic. In August 2010, The Swedish Medical Products Agency (MPA) and The Finnish National Institute for Health and Welfare (THL) launched investigations regarding the development of narcolepsy as a possible side effect to Pandemrix flu vaccination in children,[130] and found a 6.6-fold increased risk among children and youths, resulting in 3.6 additional cases of narcolepsy per 100,000 vaccinated subjects.[131]

In February 2011, The Finnish National Institute for Health and Welfare (THL) concluded that there is a clear connection between the Pandemrix vaccination campaign of 2009 and 2010, and the narcolepsy epidemic in Finland. A total of 152 cases of narcolepsy were found in Finland during 2009–2010, and ninety percent of them had received the Pandemrix vaccination.[132][133][134] Sweden however observed very few influenza cases totally in 2009 and especially 2010 as compared to most other years.[135] In 2015, it was reported that the British Department of Health was paying for Sodium oxybate medication for 80 patients who are taking legal action over problems linked to the use of the swine flu vaccine, at a cost to the government of £12,000 per patient per year.[136]

2012 criminal and civil settlement

Overview

In July 2012, GSK pleaded guilty in the United States to criminal charges, and agreed to pay US$3 billion, in what was the largest settlement until then between the Justice Department and a drug company. The US$3 billion included a criminal fine of US$956,814,400 and forfeiture of US$43,185,600. The remaining US$2 billion covered a civil settlement with the government under the False Claims Act. The investigation was launched largely on the basis of information from four whistleblowers who filed qui tam (whistleblower) lawsuits against the company under the False Claims Act.[9]

The charges stemmed from GSK's promotion of the anti-depressants Paxil (paroxetine) and Wellbutrin (bupropion) for unapproved uses from 1998 to 2003, specifically as suitable for patients under the age of 18, and from its failure to report safety data about Avandia (rosiglitazone), both in violation of the Federal Food, Drug, and Cosmetic Act. Other drugs promoted for unapproved uses were two inhalers, Advair (fluticasone/salmeterol) and Flovent (fluticasone propionate), as well as Zofran (ondansetron), Imitrex (sumatriptan), Lotronex (alosetron) and Valtrex (valaciclovir).[9]

The settlement also covered reporting false best prices and underpaying rebates owed under the Medicaid Drug Rebate Program, and kickbacks to physicians to prescribe GSK's drugs. There were all-expenses-paid spa treatments and hunting trips for doctors and their spouses, speakers' fees at conferences, and payment for articles ghostwritten by the company and placed by physicians in medical journals.[9] The company set up a ghostwriting programme called CASPPER, initially to produce articles about Paxil but which was extended to cover Avandia.[137]

As part of the settlement GSK signed a five-year corporate integrity agreement with the Department of Health and Human Services, which obliged the company to make major changes in the way it did business, including changing its compensation programmes for its sales force and executives, and to implement and maintain transparency in its research practices and publication policies.[9] It announced in 2013, that it would no longer pay doctors to promote its drugs or attend medical conferences, and that its sales staff would no longer have prescription targets.[138]

Rosiglitazone (Avandia)

Further information: Rosiglitazone § Adverse effects, and Rosiglitazone § Lawsuits

The 2012 settlement included a criminal fine of US$242,612,800 for failing to report safety data to the FDA about Avandia (rosiglitazone), a diabetes drug approved in 1999, and a civil settlement of US$657 million for making false claims about it. The Justice Department said GSK had promoted rosiglitazone to physicians with misleading information, including that it conferred cardiovascular benefits despite an FDA-mandated label warning of cardiovascular risks.[9]

In 1999, John Buse, a diabetes specialist, told medical conferences that rosiglitazone might carry an increased risk of cardiovascular problems. GSK threatened to sue him, called his university head of department, and persuaded him to sign a retraction.[139] GSK raised questions internally about the drug's safety in 2000, and in 2002, the company ghostwrote an article in Circulation describing a GSK funded clinical trial that suggested rosiglitazone might have a beneficial effect on cardiovascular risk.[140] From 2001, reports began to link the thiazolidinediones (the class of drugs to which rosiglitazone belongs) to heart failure.[141] In April that year, GSK began a six-year, open-label, randomized trial, known as RECORD, to examine rosiglitazone and cardiovascular events.[142] Two GSK meta-analyses in 2005, and 2006, showed an increased risk of cardiovascular problems with rosiglitazone; the information was passed to the FDA and posted on the company website, but not otherwise published. By December 2006, rosiglitazone had become the top-selling diabetes drug, with annual sales of US$3.3 billion.[141]

In June 2007, The New England Journal of Medicine published a meta-analysis that associated the drug with an increased risk of heart attack.[143] GSK had reportedly tried to persuade one of the authors, Steven Nissen, not to publish it, after receiving an advance copy from one of the journal's peer reviewers, a GSK consultant.[144][145] In July 2007, FDA scientists suggested that rosiglitazone had caused 83,000 excess heart attacks between 1999 and 2007.[146]: 4 [147] The FDA placed restrictions on the drug, including adding a boxed warning, but did not withdraw it.[148] (In 2013, the FDA rejected that the drug had caused excess heart attacks.)[149] A Senate Finance Committee inquiry concluded in 2010, that GSK had sought to intimidate scientists who had concerns about rosiglitazone.[146] In February that year the company tried to halt publication of an editorial about the controversy by Nissen in the European Heart Journal.[150]

The results of GSK's RECORD trial were published in June 2009. It confirmed an association between rosiglitazone and an increased risk of heart failure and fractures, but not of heart attack, and concluded that it "does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose-lowering drugs."[142] Steven Nissan and Kathy Wolkski argued that the study's low event rates reduced its statistical power.[151] In September 2009, rosiglitazone was suspended in Europe.[152] The results of the RECORD study were confirmed in 2013, by the Duke Clinical Research Institute, in an independent review required by the FDA.[153] In November that year the FDA lifted the restrictions it had placed on the drug.[154] The boxed warning about heart attack was removed; the warning about heart failure remained in place.[149]

Paroxetine (Paxil/Seroxat)

Main article: Study 329
 
Paroxetine, known as Paxil and Seroxat

GSK was fined for promoting Paxil/Seroxat (paroxetine) for treating depression in the under-18s, although the drug had not been approved for pediatric use.[9] Paxil had US$4.97 billion worldwide sales in 2003.[155] The company conducted nine clinical trials between 1994, and 2002, none of which showed that Paxil helped children with depression.[156] From 1998, to 2003, it promoted the drug for the under-18s, paying physicians to go on all-expenses paid trips, five-star hotels and spas.[9] From 2004, Paxil's label, along with those of similar drugs, included an FDA-mandated boxed warning that it might increase the risk of suicidal ideation and behaviour in patients under 18.[9]

An internal SmithKline Beecham document said in 1998, about withheld data from two GSK studies: "It would be commercially unacceptable to include a statement that [pediatric] efficacy had not been demonstrated, as this would undermine the profile of paroxetine."[155][157] The company ghostwrote an article, published in 2001, in the Journal of the American Academy of Child and Adolescent Psychiatry, that misreported the results of one of its clinical trials, Study 329.[9][158] The article concluded that Paxil was "generally well tolerated and effective for major depression in adolescents."[159] The suppression of the research findings is the subject of the 2008 book Side Effects by Alison Bass.[160][161]

For 10 years GSK marketed Paxil as non-habit forming. In 2001, 35 patients filed a class-action suit alleging they had had withdrawal symptoms, and in 2002, a Los Angeles court issued an injunction preventing GSK from advertising that the drug was not habit forming.[162] The court withdrew the injunction after the FDA objected that the court had no jurisdiction over drug marketing that the FDA had approved.[163] In 2003, a World Health Organization committee reported that Paxil was among the top 30 drugs, and top three antidepressants, for which dependence had been reported.[164][n 2]

Bupropion (Wellbutrin)

The company was also fined for promoting Wellbutrin (bupropion) – approved at the time for major depressive disorder and also sold as a smoking-cessation aid, Zyban – for weight loss and the treatment of attention deficit hyperactivity disorder, sexual dysfunction and substance addiction. GSK paid doctors to promote these off-label uses, and set up supposedly independent advisory boards and Continuing Medical Education programmes.[9]

China

Main article: GSK China Scandal

In 2013, Chinese authorities announced that, since 2007, GSK had funnelled HK$3.8 billion in kickbacks to GSK managers, doctors, hospitals and others who prescribed their drugs, using over 700 travel agencies and consulting firms.[165] Chinese authorities arrested four GSK executives as part of a four-month investigation into claims that doctors were bribed with cash and sexual favours.[166] In 2014, a Chinese court found the company guilty of bribery and imposed a fine of US$490 million. Mark Reilly, the British head of GSK's Chinese operations, received a three-year suspended prison sentence after a one-day trial held in secret.[167] Reilly was reportedly deported from China and dismissed by the company.[168]

Market manipulation in the UK

In February 2016, the company was fined over £37 million in the UK by the Competition and Markets Authority for paying Generics UK, Alpharma and Norton Healthcare more than £50m between 2001, and 2004, to keep generic varieties of paroxetine out of the UK market. The generics companies were fined a further £8 million. At the end of 2003, when generics became available in the UK, the price of paroxetine dropped by 70 percent.[169]

Miscellaneous

Italian police sought bribery charges in May 2004, against 4,400 doctors and 273 GSK employees. GSK and its predecessor were accused of having spent £152m on physicians, pharmacists and others, giving them cameras, computers, holidays and cash. Doctors were alleged to have received cash based on the number of patients they treated with a cancer drug, topotecan (Hycamtin).[170] The following month prosecutors in Munich accused 70–100 doctors of having accepted bribes from SmithKline Beecham between 1997, and 1999. The inquiry was opened over allegations that the company had given over 4,000 hospital doctors money and free trips.[171][172] All charges were dismissed by the Verona court in January 2009.[173]

In 2006, in the United States GSK settled the largest tax dispute in IRS history, agreeing to pay US$3.1 billion. At issue were Zantac and other products sold in 1989–2005. The case revolved around intracompany transfer pricing—determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS.[174][175]

The UK's Serious Fraud Office (SFO) opened a criminal inquiry in 2014 into GSK's sales practices, using powers granted by the Bribery Act 2010.[176] The SFO said it was collaborating with Chinese authorities to investigate bringing charges in the UK related to GSK's activities in China, Europe and the Middle East.[177] Also as of 2014, the US Department of Justice was investigating GSK with reference to the Foreign Corrupt Practices Act.[178]

In October 2020, GSK told some staff that while at work they should disable the contact tracing function of the NHS test-and-trace app which monitors the spread of COVID-19. GSK explained the reason for this was due to social distancing measures in place at their sites rendering the technology unnecessary.[179]

See also

Notes

  1. ^ Glaxo Wellcome was formed from Glaxo's 1995 acquisition of The Wellcome Foundation and SmithKline Beecham from the 1989 merger of the Beecham Group and the SmithKline Beckman Corporation.
  2. ^ World Health Organization Expert Committee on Drug Dependence, 2003: "The Committee noted the striking number of reports on paroxetine and 'withdrawal syndrome' ... The representative of Consumers International reported that a number of patients had experienced difficulty in withdrawing from SSRIs in general. It was agreed that withdrawal was indeed a problem in some patients, but there was a difference of opinion on the degree of dependence that was involved, given the possibility that the need for treatment of resistant or relapsing disease could make these drugs indispensable for patient care. The Committee expressed concern about the possibility of inappropriate prescribing resulting in the risk of problems of withdrawal outweighing the benefits of treatment with SSRIs."[164]

References

  1. ^ "Full year and fourth quarter 2022" (PDF). GlaxoSmithKline. Retrieved 14 February 2023.
  2. ^ "New GSK debuts with renewed purpose, strategy and brand identity as it says goodbye to consumer business". End Points News. 9 June 2022. Retrieved 14 February 2023.
  3. ^ "Headquarters | GSK US". us.gsk.com.
  4. ^ "GlaxoSmithKline on the Forbes Top Multinational Performers List". Forbes. Retrieved 11 December 2017.
  5. ^ "Global 500". Fortune. Retrieved 10 August 2022.
  6. ^ "FTSE All-Share Index Ranking". stockchallenge.co.uk. Retrieved 10 August 2022.
  7. ^ a b c Plumridge, Hester (24 July 2014). "Glaxo Files Its Entry in Race for a Malaria Vaccine". The Wall Street Journal.

    Lorenzetti, Laura (24 July 2014). "GlaxoSmithKline seeks approval on first-ever malaria vaccine". Fortune.

  8. ^ a b World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  9. ^ a b c d e f g h i j k "GlaxoSmithKline to Plead Guilty and Pay $3 Billion to Resolve Fraud Allegations and Failure to Report Safety Data", United States Department of Justice, 2 July 2012.
    Katie Thomas and Michael S. Schmidt, "Glaxo Agrees to Pay $3 Billion in Fraud Settlement", The New York Times, 2 July 2012.

    Simon Neville, "GlaxoSmithKline fined $3bn after bribing doctors to increase drugs sales", The Guardian, 3 July 2012.

  10. ^ R. P. T. Davenport-Hines, Judy Slinn, Glaxo: A History to 1962, Cambridge University Press, 1992, pp. 7–13.
  11. ^ David Newton, Trademarked: A History of Well-Known Brands, from Airtex to Wright's Coal Tar, The History Press, 2012, p. 435.
  12. ^ a b c d David J. Ravenscraft, William F. Long, "Paths to Creating Value in Pharmaceutical Mergers," in Steven N. Kaplan (ed.), Mergers and Productivity, University of Chicago Press, 2000.
  13. ^ a b c d e f . GlaxoSmithKline. Archived from the original on 8 June 2011. Retrieved 18 April 2011.
  14. ^ New "Glaxo" Company. The Times, Tuesday, 15 October 1935; pg. 22; Issue 47195
  15. ^ J. Nathan And "Glaxo" Reorganization. The Times, Wednesday, 8 January 1947; pg. 8; Issue 50653
  16. ^ Joseph Nathan & Co. The Times, Thursday, 20 February 1947; pg. 8; Issue 50690
  17. ^ 1664-1964 "The Story of a Town", Tricentennial Committee.
  18. ^ "Addition to Factory", The Eastchester Citizen-Bulletin, 19 November 1924
  19. ^ Peter Pennoyer, Anne Walker, The Architecture of Delano & Aldrich, W. W. Norton & Company, 2003, p. 188.
  20. ^ "Iconic Burroughs Wellcome Headquarters Open for Rare Public Tour" 28 August 2018 at the Wayback Machine, Triangle Modernist Houses, press release, 8 October 2012.
  21. ^ Cummings, Alex Sayf (13 June 2016). "Into the Spaceship: A Visit to the Old Burroughs Wellcome Building". Tropics of Meta historiography for the masses. Retrieved 25 November 2019.
  22. ^ Bouton, Katherine (29 January 1989). "The Nobel Pair". The New York Times. Retrieved 12 March 2020.
  23. ^ a b Stradling, Richard (21 September 2020). "United Therapeutics to demolish an RTP landmark building". News & Observer.
  24. ^ Mark S. Lesney, "The ghosts of pharma past", Modern Drug Discovery, January 2004, pp. 25–26.
  25. ^ "10,000 face Glaxo's axe at Wellcome". The Independent. 15 June 1995.
  26. ^ Grimond, Magnus (21 June 1995). . The Independent. Archived from the original on 26 February 2014.
  27. ^ Grimond, Magnus (7 September 1995). "Glaxo Wellcome plans to axe 7,500 jobs". The Independent.
  28. ^ "Glaxo to Acquire Affymax". The New York Times. 27 January 1995. Retrieved 12 March 2020.
  29. ^ "Outlook: Glaxo Wellcome". The Independent. 30 March 1999.
  30. ^ "Company of the week: Glaxo Wellcome". The Independent. 1 August 1999.
  31. ^ "Profile: Glaxo Wellcome". BBC News. 17 January 2000.
  32. ^ Corely, T.A.B. (2011). Beechams, 1848-2000: from Pills to Pharmaceuticals. Crucible Books. ISBN 978-1905472147.
  33. ^ Kleinfield, N. R. (29 May 1984). "Smithkline: One-Drug Image". The New York Times. ISSN 0362-4331. Retrieved 30 September 2019.
  34. ^ "SmithKline Beckman Corp. and International Clinical Laboratories Inc. announced..." UPI. Retrieved 30 September 2019.
  35. ^ Lohr, Steve (13 April 1989). "SmithKline, Beecham to Merge". The New York Times. ISSN 0362-4331. Retrieved 30 September 2019.
  36. ^ "The new alchemy – The drug industry's flurry of mergers is based on a big gamble". The Economist. 20 January 2000.
  37. ^ Gershon D (May 2000). "Partners resolve their differences and unite at the second attempt". Nature. 405 (6783): 258. doi:10.1038/35012210. PMID 10821289. S2CID 23140509.
  38. ^ "Hall that glitters isn't shareholder gold". The Daily Telegraph. 15 July 2002. Archived from the original on 11 January 2022.
  39. ^ "GlaxoSmithKline Completes the Purchase of Block Drug for $1.24 Billion". PR Newswire. Retrieved 1 August 2010.
  40. ^ Stouffer, Rick (9 October 2006). "Glaxo unit buys Breathe Right maker". Trib Live.
  41. ^ "Sir Christopher Gent to exit GlaxoSmithKline", The Daily Telegraph, 28 October 2012.
  42. ^ Ben Hirschler (24 May 2007). "Glaxo China R&D centre to target neurodegeneration". Reuters.
    Cyranoski, David (29 October 2008). "Pharmaceutical futures: Made in China?". Nature.
  43. ^ "Corporate Executive Team", GlaxoSmithKline. Retrieved 16 November 2013. 14 October 2012 at the Wayback Machine
  44. ^ "Andrew Witty's journey from Graduate to GSK CEO", GlaxoSmithKline, 12 August 2008; "Andrew Philip Witty", Bloomberg.
  45. ^ Ruddick, Graham (20 April 2009). "GlaxoSmithKline buys Stiefel for $3.6bn". The Daily Telegraph. Archived from the original on 11 January 2022.
  46. ^ "FDA Approves Additional Vaccine for 2009 H1N1 Influenza Virus". US Food and Drug Administration (FDA). 16 November 2009.
  47. ^ Jack, Andrew (16 April 2009). "Companies / Pharmaceuticals – GSK and Pfizer to merge HIV portfolios". Financial Times. Archived from the original on 10 December 2022.
  48. ^ , InfoGrok.
  49. ^ Sandle, Paul (13 December 2010). "UPDATE 2-Glaxo buys protein-drinks firm Maxinutrition". Reuters.
  50. ^ Ranii, David (21 December 2011). . News & Observer. Archived from the original on 15 April 2012.
  51. ^ "GSK confirms 500 mln stg UK investment plans", Reuters, 22 March 2012.
  52. ^ European Biotechnology News 16 May 2012. GSK acquires Cellzome 100%: Britain's largest drugmaker GlaxoSmithKline will pay about €75m in cash to acquire Cellzome AG completely 4 June 2016 at the Wayback Machine; John Carroll for FierceBiotech 15 May 2012 GSK snags proteomics platform tech in $98M Cellzome buyout
  53. ^ John Carroll for FiercePharma. 12 June 2012 GSK continues deal spree with $302M pact for Basilea eczema drug; Basilea Pharmaceutica Press Release. 11 June 2012 Basilea enters into global agreement with Stiefel, a GSK company, for Toctino (alitretinoin)
  54. ^ Matthew Herper, "Three Lessons From GlaxoSmithKline's Purchase Of Human Genome Sciences", Forbes, 16 July 2012.
  55. ^ a b c Angela Monaghan "Ribena and Lucozade sold to Japanese drinks giant", The Guardian, 9 September 2013
  56. ^ Hirschler, Ben (10 March 2014). "GSK pays $1 billion to lift Indian unit stake to 75 percent". Reuters. Retrieved 10 March 2014.
  57. ^ Bray, Chad; Jolly, David (23 April 2014). "Novartis and Glaxo Agree to Trade $20 Billion in Assets". The New York Times. Retrieved 12 March 2020.
  58. ^ Rockoff, Jonathan D.; Whalen, Jeanne; Falconi, Marta (22 April 2014). "Deal Flurry Shows Drug Makers' Swing Toward Specialization". The Wall Street Journal. Retrieved 12 March 2020.
  59. ^ "GEN - News Highlights:GSK Acquires GlycoVaxyn for $190M". GEN. 11 February 2015.
  60. ^ "Pfizer Buys Two GSK Meningitis Vaccines for $130M". GEN. 22 June 2015. Retrieved 25 March 2016.
  61. ^ James Quinn, "Sir Philip Hampton to chair Glaxo", The Daily Telegraph, 25 September 2014.
  62. ^ Herper, Matthew. "GlaxoSmithKline Appoints Big Pharma's First Woman Chief Executive". Forbes. Retrieved 11 December 2017.
  63. ^ Yeomans, Jon (20 September 2016). "Emma Walmsley becomes latest female CEO in FTSE 100 as she replaces Sir Andrew Witty at GSK". The Telegraph. Daily Telegraph, London. from the original on 21 September 2016. Retrieved 20 September 2016.
  64. ^ "GlaxoSmithKline boosts stake in Saudi Arabia unit". Reuters. 18 December 2017.
  65. ^ a b "GlaxoSmithKline considers splitting up the group - FT". Reuters. 21 July 2018. Retrieved 23 July 2018.
  66. ^ a b Gruber, Kane Wu (28 November 2018). "Unilever in pole position to swallow GSK's Indian Horlicks business". Reuters. Retrieved 28 November 2018.
  67. ^ "GlaxoSmithKline taps Unilever as lead bidder in Indian Horlicks buyout: report". FiercePharma. Retrieved 28 November 2018.
  68. ^ "Unilever swallows GSK's Indian Horlicks business for $3.8 billion". Reuters. 3 December 2018. Retrieved 3 December 2018.
  69. ^ "GSK slides after buying cancer firm Tesaro for hefty $5.1 billion". Reuters. 3 December 2018. Retrieved 3 December 2018.
  70. ^ Sagonowsky, Eric (21 October 2019). "Zeroing in on fast-growing vaccines, GSK sheds 2 shots to Bavarian Nordic for up to $1.1B". FiercePharma. from the original on 5 January 2020. Retrieved 26 January 2020.
  71. ^ "GSK agrees to divest rabies and tick-borne encephalitis vaccines to Bavarian Nordic". gsk.com. Retrieved 26 January 2020.
  72. ^ Schuetze, Pushkala Aripaka (20 July 2020). "GSK buys 10% of CureVac in vaccine tech deal". Reuters – via uk.reuters.com.
  73. ^ "GSK buys out Novartis in $13 billion consumer healthcare shake-up". Reuters. 27 March 2018. Retrieved 27 March 2018.
  74. ^ a b "Drugmaker GSK to split after striking Pfizer consumer health deal". Reuters. 19 December 2018. Retrieved 19 December 2018.
  75. ^ "Hello, Haleon: GlaxoSmithKline reveals name of £60bn consumer health spin-out". Evening Standard. 22 February 2022. Retrieved 23 February 2022.
  76. ^ Cavale, Siddharth; Burger, Ludwig; Dey, Mrinmay (15 January 2022). "GSK rejects 50-billion-pound Unilever offer for consumer assets". Reuters – via www.reuters.com.
  77. ^ "Pfizer to exit GSK consumer health joint venture after London listing". Financial Times. 1 June 2022. Archived from the original on 10 December 2022. Retrieved 15 June 2022.
  78. ^ Grover, Natalie; Shabong, Yadarisa (13 April 2022). "GSK to buy Sierra Oncology amid pressure to boost drug pipeline". Reuters – via www.reuters.com.
  79. ^ "GSK Bolsters Vaccines Business with $3.3B Affinivax Buy". Biospace. 31 May 2022. Retrieved 9 June 2022.
  80. ^ "Change of name". London Stock Exchange. 16 May 2022. Retrieved 2 June 2022.
  81. ^ "GSK: To Acquire The Late-stage Biopharmaceutical Group For $14.75 Per Share". MarketWatch. Retrieved 18 April 2023.
  82. ^ "Most-recognized brands: Anti-infectives, December 2013". Drugs.com.
  83. ^ Geddes AM, Klugman KP, Rolinson GN (December 2007). "Introduction: historical perspective and development of amoxicillin/clavulanate". Int J Antimicrob Agents. 30 (Suppl 2): S109–12. doi:10.1016/j.ijantimicag.2007.07.015. PMID 17900874.
  84. ^ Brown AG (August 1986). "Clavulanic acid, a novel beta-lactamase inhibitor--a case study in drug discovery and development". Drug Des Deliv. 1 (1): 1–21. PMID 3334541.
  85. ^ "mupirocin search results". DailyMed. Retrieved 12 March 2020.
  86. ^ Richards DM, Brogden RN (February 1985). "Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use". Drugs. 29 (2): 105–61. doi:10.2165/00003495-198529020-00002. PMID 3884319.
  87. ^ a b "6-Mercaptopurine". Chemical & Engineering News.
  88. ^ a b c d "George Hitchings and Gertrude Elion". Science History Institute. June 2016.
  89. ^ a b Elion GB (1989). "The purine path to chemotherapy". Science. 244 (4900): 41–7. Bibcode:1989Sci...244...41E. doi:10.1126/science.2649979. PMID 2649979.
  90. ^ a b Altman, Lawrence K. (23 February 1999). "Gertrude Elion, Drug Developer, Dies at 81". The New York Times.
  91. ^ "Press release: Malaria vaccine candidate reduces disease over 18 months of follow-up in late-stage study of more than 15,000 infants and young children". PATH.
  92. ^ Birkett AJ, Moorthy VS, Loucq C, et al. (April 2013). "Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities". Vaccine. 31 (Supplement 2): B233–43. doi:10.1016/j.vaccine.2013.02.040. PMID 23598488.
  93. ^ . GlaxoSmithKline. Archived from the original on 7 April 2014.
  94. ^ McNeil, Donald G. Jr. (18 October 2011). "Scientists See Promise in Vaccine for Malaria". The New York Times.
  95. ^ Majumdar, Ramanuj (2007). Product management in India (3rd ed.). PHI Learning. p. 242. ISBN 978-81-203-3383-3.
  96. ^ Aaron Smith, "Alli weight-loss drug recalled for tampering", CNN, 27 March 2014.
  97. ^ "About us: what we do", GlaxoSmithKline, accessed 16 November 2013 13 October 2013 at the Wayback Machine
  98. ^ "Coronavirus vaccine: UK signs deal with GSK and Sanofi". BBC News. 29 July 2020.
  99. ^ "U.S. agrees to pay Sanofi and GSK $2.1 billion for 100 million doses of coronavirus vaccine". CNBC. 31 July 2020.
  100. ^ a b Reaume, Andrew (1 January 2003). "Is Corporate Venture Capital a Prescription for Success in the Pharmaceutical Industry?". The Journal of Private Equity. 6 (4): 77–87. doi:10.3905/jpe.2003.320058. JSTOR 43503355. S2CID 154182967.
  101. ^ "GSK to Acquire Celiac-Focused Sitari Pharmaceuticals". BioSpace.
  102. ^ "The Nobel Prize in Physiology or Medicine 1936". NobelPrize.org.
  103. ^ "The Nobel Prize in Physiology or Medicine 1982". NobelPrize.org.
  104. ^ Maltzman JS, Koretzky GA (April 2003). "Azathioprine: old drug, new actions". J. Clin. Invest. 111 (8): 1122–4. doi:10.1172/JCI18384. PMC 152947. PMID 12697731.
  105. ^ Elion GB (1993). "Acyclovir: discovery, mechanism of action, and selectivity". J. Med. Virol. Suppl 1: 2–6. doi:10.1002/jmv.1890410503. PMID 8245887. S2CID 37848199.
  106. ^ Koenig R (2006). "The legacy of great science: the work of Nobel Laureate Gertrude Elion lives on". Oncologist. 11 (9): 961–5. doi:10.1634/theoncologist.11-9-961. PMID 17030634.
  107. ^ (PDF). Archived from the original (PDF) on 7 February 2014.
  108. ^ Human Rights Campaign. Profile: Buyers Guide entry for GlaxoSmithKline 13 May 2016 at the Wayback Machine. Accessed 16 May 2014
  109. ^ . Ifpma.org. Archived from the original on 27 December 2008.
  110. ^ . Bill & Melinda Gates Foundation. 30 January 2012. Archived from the original on 14 March 2013. Retrieved 30 May 2013.

    "Research-based pharma pledges on neglected tropical diseases". The Pharma Letter. 31 January 2012.

  111. ^ "Global programme to eliminate lymphatic filariasis: progress report, 2014" (PDF). World Health Organization. 18 September 2015. p. 490.
  112. ^ Sarah Boseley, "Drug giant GlaxoSmithKline pledges cheap medicine for world's poor", The Guardian, 13 February 2009.
  113. ^ UNITAID 16 February 2009. UNITAID Statement on GSK Patent Pool For Neglected Diseases 27 May 2014 at the Wayback Machine
  114. ^ Tido von Schoen-Angerer, Letter to the editor, The Guardian, 16 February 2009.
  115. ^ "GlaxoSmithKline unit joins patent pool for AIDS drugs | Reuters". Reuters. 27 February 2013.
  116. ^ "Medicines Patent Pool, ViiV Healthcare Sign Licence for the Most Recent HIV Medicine to Have Received Regulatory Approval". Medicines Patent Pool.
  117. ^ Ben Goldacre, Bad Pharma, Fourth Estate, 2013 [2012], p. 387.
  118. ^ Palmer, Eric (17 January 2018). "GSK cutting jobs in sub-Saharan Africa, will rely on distributors". Fierce Pharma. Retrieved 10 January 2023.
  119. ^ "GSK stops Nairobi production as high costs and low sales eat into revenue". The East African. 15 October 2022. Retrieved 9 March 2023.
  120. ^ a b c d United States v. Glaxo Group Ltd., 410 U.S. 52 (1973).
  121. ^ a b c d e LaHatte, Gabrielle (2011). "Reverse Payments: When the Federal Trade Commission can Attack the Validity of Underlying Patents". Case Western Reserve Journal of Law, Technology & the Internet. 2: 37–73. Retrieved 19 June 2015.
  122. ^ Leslie, Christopher R. (2011). Antitrust Law and Intellectual Property Rights: Cases and Materials. Oxford University Press. pp. 574–75. ISBN 9780195337198.
  123. ^ United States v. Glaxo Group Ltd. at 62-63.
  124. ^ Jacobson, Jonathan M. (2007). Antitrust Law Developments. American Bar Association. p. 1162. ISBN 9781590318676.
  125. ^ Oliver Thring, "Consider squash and cordial", The Guardian, 7 September 2010.

    "We have Frank and Vernon to thank for Ribena" 18 April 2015 at the Wayback Machine, The Bristol Post, 17 September 2013.

  126. ^ Linus Gregoriadis, "Makers of Ribena lose fight over anti-decay claims", The Daily Telegraph, 18 January 2001.
  127. ^ Eames, David (28 March 2007). "Judge orders Ribena to fess up". The New Zealand Herald.
    Tony Jaques, "When an Icon Stumbles – The Ribena Issue Mismanaged" 4 March 2016 at the Wayback Machine, Corporate Communications: An International Journal, 13(4), 2008, pp. 394–406.

    Michael Regester, Judy Larkin, Risk Issues and Crisis Management in Public Relations, Kogan Page Publishers, 2008, p. 67ff.

  128. ^ "GlaxoSmithKline to Plead Guilty & Pay $750 Million to Resolve Criminal and Civil Liability Regarding Manufacturing Deficiencies at Puerto Rico Plant", U.S. Department of Justice, 26 October 2010.
  129. ^ a b Harris, Gardiner; Wilson, Duff (26 October 2010). "Glaxo to Pay $750 Million for Sale of Bad Products". The New York Times.
  130. ^ "The MPA investigates reports of narcolepsy in patients vaccinated with Pandemrix". The Swedish Medical Products Agency. 18 August 2010. Retrieved 19 August 2010.
  131. ^ Report from an epidemiological study in Sweden on vaccination with Pandemrix and narcolepsy, Swedish medical product agency, 30 June 2011.
  132. ^ "THL: Pandemrixilla ja narkolepsialla on selvä yhteys". Mtv3.fi. Retrieved 8 September 2018.
  133. ^ . Terveyden ja hyvinvoinnin laitos. Archived from the original on 5 September 2012. Retrieved 8 September 2018.
  134. ^ . Terveyden ja hyvinvoinnin laitos. Archived from the original on 17 May 2013. Retrieved 8 September 2018.
  135. ^ "Statistikdatabas för dödsorsaker (den öppna delen av dödsorsaksregistret)" (in Swedish). Socialstyrelsen. Retrieved 24 March 2020., diagnoskod J09, J10 och J11
  136. ^ "DH funds private prescriptions for drug denied to NHS patients". Health Service Journal. 20 July 2015. Retrieved 20 July 2015.
  137. ^ Max Baucus, Chuck Grassley, "Finance Committee Letter to the FDA Regarding Avandia", United States Senate Finance Committee, 12 July 2010.
    Jim Edwards, "Inside GSK's CASSPER Ghostwriting Program", CBS News, 21 August 2009.
  138. ^ "GSK to stop paying doctors in major marketing overhaul" 28 October 2014 at the Wayback Machine, Thomson/Reuters, 17 December 2013.
  139. ^ "The Intimidation of Dr. John Buse and the Diabetes Drug Avandia", Committee on Finance, United States Senate, November 2007, pp. 2–4.
  140. ^ Max Baucus, Chuck Grassley, "Finance Committee Letter to the FDA Regarding Avandia", United States Senate Finance Committee, 12 July 2010; for internal concerns, p. 2 and attachment E, pp. 20–35; for ghostwriting, p. 3 and attachment H, pp. 58–109; for the ghostwriting, attachment I, p. 110ff; for cover letter to Circulation, attachment I, p. 143; for the ghostwritten article, attachment I, pp. 152–158.

    Haffner SM, Greenberg AS, Weston WM, et al. (August 2002). "Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus". Circulation. 106 (6): 679–84. doi:10.1161/01.CIR.0000025403.20953.23. PMID 12163427.

  141. ^ a b Nissen SE (April 2010). "The rise and fall of rosiglitazone". European Heart Journal. 31 (7): 773–776. doi:10.1093/eurheartj/ehq016. PMID 20154334. see table 1 for timeline.
  142. ^ a b Home PD, Pocock SJ, Beck-Nielsen H, et al. (June 2009). "Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial". Lancet. 373 (9681): 2125–35. doi:10.1016/S0140-6736(09)60953-3. PMID 19501900. S2CID 25939495.
    Home PD, Pocock SJ, Beck-Nielsen H, et al. (September 2005). "Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD): study design and protocol". Diabetologia. 48 (9): 1726–35. doi:10.1007/s00125-005-1869-1. PMID 16025252.

    "RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes - Full Text View". ClinicalTrials.gov. 21 March 2017. Retrieved 12 March 2020.

  143. ^ Nissen SE, Wolski K (2007). "Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes". New England Journal of Medicine. 356 (24): 2457–71. doi:10.1056/NEJMoa072761. PMID 17517853. Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that had borderline significance.
  144. ^ Saul, Stephanie (30 January 2008). "Doctor Accused of Leak to Drug Maker". The New York Times. Retrieved 12 March 2020.
  145. ^ Harris, Gardiner (22 February 2010). "A Face-Off on the Safety of a Drug for Diabetes". The New York Times. Retrieved 12 March 2020.
  146. ^ a b "Staff report on GlaxoSmithKline and the diabetes drug Avandia", Committee on Finance, United States Senate, January 2010.
    "Grassley, Baucus Release Committee Report on Avandia", The United States Senate Committee on Finance, 20 February 2010.

    Andrew Clark, "Glaxo's handling of Avandia concerns damned by US Senate committee", The Guardian, 22 February 2010.

  147. ^ David Graham, "Assessment of the cardiovascular risks and health benefits of rosiglitazone", Office of Surveillance and Epidemiology, Food and Drug Administration, 30 July 2007.
  148. ^ "FDA Adds Boxed Warning for Heart-related Risks to Anti-Diabetes Drug Avandia. Agency says drug to remain on market, while safety assessment continues", Food and Drug Administration, 14 November 2007.
  149. ^ a b "FDA Drug Safety Communication: FDA requires removal of some prescribing and dispensing restrictions for rosiglitazone-containing diabetes medicines". Food and Drug Administration. 25 November 2013.
    Avandia. Prescribing information", Food and Drug Administration.
  150. ^ Thomas F. Lüscher; Ulf Landmesser; Frank Ruschitzka (23 April 2010). "Standing firm—the European Heart Journal, scientific controversies and the industry". European Heart Journal. 31 (10): 1157–1158. doi:10.1093/eurheartj/ehq127.
    Nissen, SE (April 2010). "The rise and fall of rosiglitazone". Eur. Heart J. 31 (7): 773–6. doi:10.1093/eurheartj/ehq016. PMID 20154334.
    Slaoui, M (2010). "The rise and fall of rosiglitazone: reply". Eur. Heart J. 31 (10): 1282–4. doi:10.1093/eurheartj/ehq118. PMID 20499440.

    Komajda, M; McMurray, JJ; Beck-Nielsen, H; Gomis, R; Hanefeld, M; Pocock, SJ; Curtis, PS; Jones, NP; Home, PD (2010). "Heart failure events with rosiglitazone in type 2 diabetes: data from the RECORD clinical trial". Eur. Heart J. 31 (7): 824–31. doi:10.1093/eurheartj/ehp604. PMC 2848325. PMID 20118174.

  151. ^ Nissen, Steven E.; Wolski, Kathy (July 2010). "Rosiglitazone RevisitedAn Updated Meta-analysis of Risk for Myocardial Infarction and Cardiovascular Mortality". Archives of Internal Medicine. 170 (14): 1191–1202. doi:10.1001/archinternmed.2010.207. PMID 20656674. That study was limited by low event rates, which resulted in insufficient statistical power to confirm or refute evidence of an increased risk for ischemic myocardial events.
  152. ^ "European Medicines Agency recommends suspension of Avandia, Avandamet and Avaglim", European Medicines Agency, 23 September 2010.
  153. ^ McHaffey, Kenneth W.; et al. (2013). "Results of a reevaluation of cardiovascular outcomes in the RECORD trial". American Heart Journal. 166 (2): 240–249. doi:10.1016/j.ahj.2013.05.004. PMID 23895806.
  154. ^ "FDA requires removal of certain restrictions on the diabetes drug Avandia", Food and Drug Administration, 25 November 2013.
    "Readjudication of the Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycemia in Diabetes Trial (RECORD)", Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Food and Drug Administration, 5–6 June 2013.
    Steven Nissen, "Steven Nissen: The Hidden Agenda Behind The FDA's New Avandia Hearings", Forbes, 23 May 2013.

    "The FDA Responds To Steve Nissen's Criticism Of Upcoming Avandia Meeting", Forbes, 23 May 2013.

  155. ^ a b W. Kondro; B. Sibbald (March 2004). "Drug company experts advised staff to withhold data about SSRI use in children". Canadian Medical Association Journal. 170 (5): 783. doi:10.1503/cmaj.1040213. PMC 343848. PMID 14993169.
  156. ^ Goldacre 2013, p. 58.
  157. ^ Samson, Kurt (December 2008). "Senate probe seeks industry payment data on individual academic researchers". Annals of Neurology. 64 (6): A7–9. doi:10.1002/ana.21271. PMID 19107985. S2CID 12019559.
  158. ^ Letter showing authorship of Study 239, Drug Industry Document Archive, University of California, San Francisco.
    Isabel Heck, "Controversial Paxil paper still under fire 13 years later", The Brown Daily Herald, 2 April 2014.
    Jureidini, Jon N.; McHenry, Leemon B.; Mansfield, Peter R. (2008). "Clinical trials and drug promotion: Selective reporting of study 329". International Journal of Risk & Safety in Medicine. 20 (1–2): 73–81. doi:10.3233/JRS-2008-0426.

    "Company hid suicide link", BBC News, 29 January 2007; "Secrets of the Drug Trials," BBC Panorama, 29 January 2007; Goldacre 2013, pp. 296–297.

  159. ^ Keller, Martin; et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial" (PDF). Journal of the American Academy of Child and Adolescent Psychiatry. 40 (7): 762–772. doi:10.1097/00004583-200107000-00010. PMID 11437014.
  160. ^ Alison Bass (2008). Side Effects: A Prosecutor, a Whistleblower, and a Bestselling Antidepressant on Trial. Algonquin Books of Chapel Hill.
  161. ^ Angell, Marcia (15 January 2009). "Drug Companies & Doctors: A Story of Corruption". The New York Review of Books. Vol. 56, no. 1.
  162. ^ "Judge: Paxil ads can't say it isn't habit-forming". Associated Press. 20 August 2002.
  163. ^ Drug and Device Law. 14 December 2006 The FDA's Amicus Briefs on Preemption

    Ronald D. White for the Los Angeles Times. 21 August 2002 U.S. Opposes Order to Pull Paxil TV Ads

  164. ^ a b , Thirty-third Report, World Health Organization, 2003, pp. 20, 25.
  165. ^ Alice Yan; Toh Han Shih (16 July 2013). "Shanghai travel agent's revenue surge led to arrests in GSK bribery case". South China Morning Post.
    "GlaxoSmithKline executives face China bribery probe". BBC News. 11 July 2013.
  166. ^ Rupert Neate and Angela Monaghan, "GlaxoSmithKline admits some staff in China involved in bribery", The Guardian, 22 July 2013.
    Rupert Neate, "GSK's China crisis: chief executive Andrew Witty speaks - as it happened", The Guardian, 24 July 2013.

    Philips, Tom (26 July 2013). "Chinese police allege Glaxo sales reps trained to offer sexual bribes". The Daily Telegraph. Archived from the original on 11 January 2022.

  167. ^ Bradsher, Keith; Buckley, Chris (19 September 2014). "China Fines GlaxoSmithKline Nearly $500 Million in Bribery Case". The New York Times.
  168. ^ Malcolm Moore, Denise Roland, "China fines Glaxo £297m for bribery, Mark Reilly sentenced", The Daily Telegraph, 19 September 2014.
  169. ^ Bradshaw, Julia (12 February 2016). "Watchdog fines GSK £37m for paying to keep generic drugs out of UK market". The Daily Telegraph. Archived from the original on 11 January 2022.
  170. ^ Hooper, John; Stewart, Heather (27 May 2004). "Over 4,000 doctors face charges in Italian drugs scandal". The Guardian. Retrieved 31 August 2022.
  171. ^ Burgermeister, J. (2004). "German prosecutors probe again into bribes by drug companies". BMJ. 328 (7452): 1333. doi:10.1136/bmj.328.7452.1333-a. PMC 420312. PMID 15178593.
  172. ^ "Glaxo probed over doctor freebies". BBC News. 12 March 2002. Retrieved 31 August 2022.
  173. ^ "GlaxoSmithKline Annual Report 2008" (PDF). p. 177. Retrieved 8 October 2015.
  174. ^ "GlaxoSmithKline to Settle Tax Dispute With U.S.", Reuters, 12 September 2006
  175. ^ "IRS Accepts Settlement Offer in Largest Transfer Pricing Dispute", IRS, 11 September 2006.
  176. ^ Kollewe, Julia (28 May 2014). "GlaxoSmithKline faces criminal investigation by Serious Fraud Office". The Guardian.
  177. ^ Ridley, Kirstin (23 July 2014). "UK fraud office liaising with China on GSK bribery case". Reuters. Retrieved 31 August 2022.
  178. ^ "GlaxoSmithKline faces bribery claims in Syria". The Telegraph. Reuters. 12 August 2014. Retrieved 31 August 2022.
  179. ^ Davies, Rob (6 October 2020). "GSK tells UK staff: turn off Covid test-and-trace app while at work". TheGuardian.com. Retrieved 6 October 2020.

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May 04, 2023
coordinates, 4881, 3169, 4881, 3169, formerly, glaxosmithkline, british, multinational, pharmaceutical, biotechnology, company, with, global, headquarters, london, england, established, 2000, merger, glaxo, wellcome, smithkline, beecham, tenth, largest, pharma. Coordinates 51 29 17 N 0 19 01 W 51 4881 N 0 3169 W 51 4881 0 3169 GSK plc formerly GlaxoSmithKline plc is a British multinational pharmaceutical and biotechnology company with global headquarters in London England 3 4 Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham n 1 GSK is the tenth largest pharmaceutical company and 294 on the 2022 Fortune Global 500 ranked behind other pharmaceutical companies China Resources Sinopharm Johnson amp Johnson Pfizer Roche AbbVie Novartis Bayer and Merck 5 GSK plcLogo since 9 June 2022Head office in Brentford London with the former GlaxoSmithKline logo taken on 30 July 2007FormerlyGlaxoSmithKline 2000 2022 TypePublic limited companyTraded asLSE GSK NYSE GSK FTSE 100 ComponentIndustryPharmaceuticalBiotechnologyPredecessorsGlaxo WellcomeSmithKline BeechamFounded27 December 2000 22 years ago 2000 12 27 HeadquartersLondon England UKArea servedWorldwideKey peopleJonathan Symonds Chairperson Emma Walmsley CEO ProductsPharmaceutical drugsvaccinesRevenue 29 324 billion 2022 Operating income 6 433 billion 2022 Net income 15 621 billion 2022 Total assets 60 146 billion 2022 Total equity 10 096 billion 2022 Number of employees70 000 2022 SubsidiariesStiefel Laboratories Tesaro ViiV Healthcare 76 5 Websitewww wbr gsk wbr comFootnotes references 1 2 The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index As of August 2022 update it had a market capitalisation of 70 billion the eighth largest on the London Stock Exchange 6 It has a secondary listing on the New York Stock Exchange The company developed the first malaria vaccine RTS S which it said in 2014 it would make available for five percent above cost 7 Legacy products developed at GSK include several listed in the World Health Organization s List of Essential Medicines such as amoxicillin mercaptopurine pyrimethamine and zidovudine 8 In 2012 under prosecution by the United States Department of Justice DoJ based on combined investigations of the Department of Health and Human Services HHS OIG FDA and FBI primarily concerning sales and marketing of the drugs Avandia Paxil and Wellbutrin GSK pleaded guilty to promotion of drugs for unapproved uses failure to report safety data and kickbacks to physicians in the United States and agreed to pay a US 3 billion 1 9bn settlement It was the largest health care fraud case to date in the US and the largest settlement by a drug company 9 Contents 1 History 1 1 Glaxo Wellcome 1 1 1 Glaxo 1 1 2 Burroughs Wellcome 1 1 3 Merger 1 2 SmithKline Beecham 1 2 1 Beecham 1 2 2 SmithKline 1 2 3 Merger 1 3 2000 Glaxo Wellcome and SmithKline Beecham merger 1 4 2001 2010 1 5 2011 2022 1 5 1 GSK Novartis consumer healthcare buy out 1 5 2 GSK Pfizer joint venture 1 5 3 Subsequent split 1 6 Recent developments 1 6 1 Acquisition history diagram 2 Research areas and products 2 1 Pharmaceuticals 2 2 Malaria vaccine 2 3 Consumer healthcare 2 4 Facilities 2 5 COVID 19 vaccine 3 Venture arms 4 Recognition philanthropy and social responsibility 4 1 Scientific recognition 4 2 Philanthropy and social responsibility 5 Controversies 5 1 1973 Antitrust case over griseofulvin 5 2 2000s Ribena 5 3 SB Pharmco Puerto Rico 5 4 2010 Pandemrix connected with narcolepsy 5 5 2012 criminal and civil settlement 5 5 1 Overview 5 5 2 Rosiglitazone Avandia 5 5 3 Paroxetine Paxil Seroxat 5 5 4 Bupropion Wellbutrin 5 6 China 5 7 Market manipulation in the UK 5 8 Miscellaneous 6 See also 7 Notes 8 References 9 External linksHistory EditGlaxo Wellcome Edit The Glaxo factory built in 1918 in Bunnythorpe New Zealand with the Glaxo Laboratories sign still visible Glaxo Edit Joseph Nathan and Co was founded in 1873 as a general trading company in Wellington New Zealand by a Londoner Joseph Edward Nathan 10 In 1904 it began producing a dried milk baby food from excess milk produced on dairy farms near Bunnythorpe The resulting product was first known as Defiance then as Glaxo from lacto and sold with the slogan Glaxo builds bonnie babies 11 12 306 13 The Glaxo Laboratories sign is still visible right on what is now a car repair shop on the main street of Bunnythorpe The company s first pharmaceutical product released in 1924 was vitamin D 12 306 Feeder bottle with valve and teat Glaxo Laboratories Greenford Middlesex Glaxo Laboratories was incorporated as a distinct subsidiary company in London in 1935 14 Joseph Nathan s shareholders reorganised the group s structure in 1947 making Glaxo the parent 15 and obtained a listing on the London Stock Exchange 16 Glaxo acquired Allen amp Hanburys in 1958 The Scottish pharmacologist David Jack was hired as a researcher for Allen amp Hanburys a few years after Glaxo took it over he went on to lead the company s research and development R amp D until 1987 12 306 After Glaxo bought Meyer Laboratories in 1978 it began to play an important role in the US market In 1983 the American arm Glaxo Inc moved to Research Triangle Park US headquarters research and Zebulon US manufacturing in North Carolina 13 Burroughs Wellcome Edit Burroughs Wellcome amp Company was founded in 1880 in London by the American pharmacists Henry Wellcome and Silas Burroughs The Wellcome Tropical Research Laboratories opened in 1902 In the 1920s Burroughs Wellcome established research and manufacturing facilities in Tuckahoe New York 17 18 18 19 which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1971 20 21 The Nobel Prize winning scientists Gertrude B Elion and George H Hitchings worked there and invented drugs still used many years later such as mercaptopurine 22 In 1959 the Wellcome Foundation bought Cooper McDougall amp Robertson Inc to become more active in animal health 13 When Burroughs Wellcome decided to move its headquarters the company selected Paul Rudolph to design its new building The Elion Hitchings Building was celebrated worldwide when it was built according to Paul Rudolph Heritage Foundation president Kelvin Dickinson Alex Sayf Cummings of Georgia State University wrote in 2016 that the iconic building helped define the image of RTP saying Love it or hate it Rudolph s design remains an impressively audacious creative gesture and an important part of the history of both architecture and Research Triangle Park 23 United Therapeutics which bought the building in 2012 announced plans in 2020 to tear it down 23 Merger Edit Glaxo and Wellcome merged in 1995 to form Glaxo Wellcome plc 24 12 Glaxo Wellcome restructured its R amp D operation that year cutting 10 000 jobs worldwide closing its R amp D facility in Beckenham Kent and opening a Medicines Research Centre in Stevenage Hertfordshire 25 26 27 Also that year Glaxo Wellcome acquired the California based Affymax a leader in the field of combinatorial chemistry 28 By 1999 Glaxo Wellcome had become the world s third largest pharmaceutical company by revenues behind Novartis and Merck with a global market share of around 4 per cent 29 Its products included Imigran for the treatment of migraine salbutamol Ventolin for the treatment of asthma Zovirax for the treatment of coldsores and Retrovir and Epivir for the treatment of AIDS In 1999 the company was the world s largest manufacturer of drugs for the treatment of asthma and HIV AIDS 30 It employed 59 000 people including 13 400 in the UK had 76 operating companies and 50 manufacturing facilities worldwide and seven of its products were among the world s top 50 best selling pharmaceuticals The company had R amp D facilities in Hertfordshire Kent London and Verona Italy and manufacturing plants in Scotland and the north of England It had R amp D centres in the US and Japan and production facilities in the US Europe and the Far East 31 SmithKline Beecham Edit Beecham Edit Main article Beecham Group Beecham s Clock Tower constructed 1877 part of the Beecham s factory St Helens In 1848 Thomas Beecham launched his Beecham s Pills laxative in England giving birth to the Beecham Group In 1859 Beecham opened its first factory in St Helens Lancashire By the 1960s Beecham was extensively involved in pharmaceuticals and consumer products such as Macleans toothpaste Lucozade and synthetic penicillin research 13 32 SmithKline Edit Main article SmithKline amp French John K Smith opened his first pharmacy in Philadelphia in 1830 In 1865 Mahlon Kline joined the business which 10 years later became Smith Kline amp Co In 1891 it merged with French Richard and Company and in 1929 changed its name to Smith Kline amp French Laboratories as it focused more on research Years later it bought Norden Laboratories a business doing research into animal health and Recherche et Industrie Therapeutiques in Belgium in 1963 to focus on vaccines The company began to expand globally buying seven laboratories in Canada and the United States in 1969 In 1982 it bought Allergan a manufacturer of eye and skincare products 13 Smith Kline amp French merged with Beckman Inc in 1982 and changed its name to SmithKline Beckman 33 In 1988 it bought International Clinical Laboratories 34 Merger Edit In 1989 SmithKline Beckman merged with Beecham Group to form SmithKline Beecham P L C 35 The headquarters moved from the United States to England To expand R amp D in the United States the company bought a new research center in 1995 another opened in 1997 in England at New Frontiers Science Park Harlow 13 2000 Glaxo Wellcome and SmithKline Beecham merger Edit Glaxo Wellcome and SmithKline Beecham announced their intention to merge in January 2000 The merger was completed on 27 December that year forming GlaxoSmithKline GSK 36 37 The company s global headquarters are at GSK House Brentford London officially opened in 2002 by then Prime Minister Tony Blair The building was erected at a cost of 300 million and as of 2002 update was home to 3 000 administrative staff 38 2001 2010 Edit Andrew Witty GSK s CEO from May 2008 to April 2017 GSK completed the acquisition of New Jersey based Block Drug in 2001 for US 1 24 billion 39 In 2006 GSK acquired the US based consumer healthcare company CNS Inc whose products included Breathe Right nasal strips and FiberChoice dietary supplements for US 566 million in cash 40 Chris Gent previously CEO of Vodafone was appointed chairman of the board in 2005 41 GSK opened its first R amp D centre in China in 2007 in Shanghai initially focused on neurodegenerative diseases 42 Andrew Witty became the chief executive officer in 2008 43 Witty joined Glaxo in 1985 and had been president of GSK s Pharmaceuticals Europe since 2003 44 In 2009 GSK acquired Stiefel Laboratories then the world s largest independent dermatology drug company for US 3 6 billion 45 In November 2009 the FDA approved GSK s vaccine for 2009 H1N1 influenza protection manufactured by the company s ID Biomedical Corp in Canada 46 Also in November 2009 GSK formed a joint venture with Pfizer to create ViiV Healthcare which specializes in HIV research 47 In 2010 the company acquired Laboratorios Phoenix an Argentine pharmaceutical company for US 253m 48 and the UK based sports nutrition company Maxinutrition for 162 million US 256 million 49 2011 2022 Edit In 2011 in a US 660 million deal Prestige Brands Holdings took over 17 GSK brands with sales of US 210 million including BC Powder Beano Ecotrin Fiber Choice Goody s Powder Sominex and Tagamet 50 In 2012 the company announced that it would invest 500 million in manufacturing facilities in Ulverston northern England designating it as the site for a previously announced biotech plant 51 In May that year it acquired CellZome a German biotech company for US 98 million 52 and in June worldwide rights to alitretinoin Toctino an eczema drug for US 302 million 53 In 2013 GSK acquired Human Genome Sciences HGS for US 3 billion the companies had collaborated on developing the lupus drug Belimumab Benlysta albiglutide for type 2 diabetes and darapladib for atherosclerosis 54 and in September sold its beverage division to Suntory This included the brands Lucozade and Ribena however the deal did not include Horlicks 55 In March 2014 GSK paid US 1 billion to raise its stake in its Indian pharmaceutical unit GlaxoSmithKline Pharmaceuticals to 75 percent as part of a move to focus on emerging markets 56 In April 2014 Novartis and Glaxo agreed on more than US 20 billion in deals with Novartis selling its vaccine business to GSK and buying GSK s cancer business 57 58 In February 2015 GSK announced that it would acquire GlycoVaxyn a Swiss pharmaceutical company for US 190 million 59 and in June that year that it would sell two meningitis drugs to Pfizer Nimenrix and Mencevax for around US 130 million 60 Philip Hampton at that time chair of the Royal Bank of Scotland became GSK chairman in September 2015 61 On 31 March 2017 Emma Walmsley became CEO She is the first female CEO of the company 62 63 In December 2017 Reuters reported that Glaxo had increased its stake in its Saudi Arabian unit to 75 from 49 taking over control from its Saudi partner Banaja KSA Holding Company 64 With respect to rare diseases the company divested its portfolio of gene therapy drugs to Orchard Therapeutics in April 2018 65 In November 2018 Reuters reported that Unilever was in prime position to acquire GSK s interest in its Indian unit GlaxoSmithKline Consumer Healthcare Ltd in a sale that could generate around US 4 billion for the company 66 Nestle and Coca Cola have also been reported to be interested in the business unit as they look to strengthen their presence in India 66 67 On 3 December 2018 GSK announced that Unilever would acquire the Indian listed GlaxoSmithKline Consumer Healthcare business for US 3 8 billion 2 98 billion Unilever will pay the majority of the deal in cash with the remaining being paid in shares in its Indian operation Hindustan Unilever Limited Upon completion GSK will then own around 5 7 of Hindustan Unilever Limited selling those shares in a number of tranches 68 The same day the company also announced it would acquire oncology specialist Tesaro for US 5 1 billion The deal will give GSK control of ovarian cancer treatment Zejula a member of the class of poly ADP ribose polymerase PARP inhibitors 69 In October 2019 GSK agreed to sell its rabies vaccine RabAvert and its tick borne encephalitis vaccine Encepur to Bavarian Nordic for US 1 06 billion 955 million 70 71 In July 2020 GSK acquired a 10 stake in German biotech company CureVac 72 GSK Novartis consumer healthcare buy out Edit In March 2018 GSK announced that it has reached an agreement with Novartis to acquire Novartis s 36 5 stake in their Consumer Healthcare Joint Venture for US 13 billion 9 2 billion 73 65 GSK Pfizer joint venture Edit In December 2018 GSK announced that it along with Pfizer had reached an agreement to merge and combine their consumer healthcare divisions into a single entity The combined entity would have sales of around 9 8 billion 12 7 billion with GSK maintaining a 68 controlling stake in the joint venture Pfizer would own the remaining 32 shareholding The deal builds on an earlier 2018 deal where GSK bought out Novartis stake in the GSK Novartis consumer healthcare joint business 74 Subsequent split Edit GSK s former logo used until 9 June 2022 The culmination of the Consumer Healthcare string of deals will result in GSK splitting into two separate companies via a demerger and subsequent listing of the joint venture This will create two publicly traded companies one focusing on pharmaceuticals and research amp development the other on consumer healthcare On 22 February 2022 GSK announced that the spin off consumer healthcare company will be called Haleon 74 75 In January 2022 the company announced that they had received three unsolicited offers from Unilever to acquire the Consumer Healthcare business unit with the final proposal valuing the business unit at 50 billion 41 7 billion in cash plus 8 3 billion in Unilever shares 76 Subsequently GSK declined all outside offers attempts to acquire its consumer healthcare business and moved forward with its plan to complete the demerger from the main biopharmaceutical business 77 Recent developments Edit In April 2022 the business announced it would acquire Sierra Oncology Inc for 1 9 billion 55 per share 78 In May 2022 GSK announced it would acquire Affinivax and its phase II 24 valent pneumococcal vaccine candidate for up to 3 3 billion strengthening its vaccine business 79 On 16 May 2022 the company changed its name from GlaxoSmithKline to GSK 80 In April 2023 GSK announced it would acquire BELLUS Health Inc for 2 0 billion 81 Acquisition history diagram Edit GlaxoSmithKline StructureGSK GlaxoSmithKline SmithKline Beecham Plc Renamed 1989 SmithKline Beckman Renamed 1982 SmithKline RIT Renamed 1968 Smith Kline amp French Reorganized 1929 into Smith Kline and French Laboratories French Richards and Company Acquired 1891 Smith Kline and Company Recherche et Industrie Therapeutiques Acquired 1968 Beckman Instruments Inc Merged 1982 Sold 1989 Specialized Instruments Corp Acquired 1954 Offner Electronics Acquired 1961 International Clinical Laboratories Acquired 1989 Reckitt amp Colman Acquired 1999 Beecham Group Plc Merged 1989 Beecham Group Ltd S E Massengill Company Acquired 1971 C L Bencard Acquired 1953 County Chemicals Norcliff Thayer Acquired 1986 Glaxo Wellcome Glaxo Merged 1995 Joseph Nathan amp Co Allen amp Hanburys Founded 1715 acquired 1958 Meyer Laboratories Merged 1978 Affymax Acquired 1995 Wellcome Foundation Renamed 1924 merged 1995 Burroughs Wellcome amp Company Founded 1880 McDougall amp Robertson Inc Acquired 1959 Block Drug Acquired 2001 CNS Inc Acquired 2006 Stiefel Laboratories Acquired 2009 Laboratorios Phoenix Acquired 2010 Maxinutrition Acquired 2010 CellZome Acquired 2011 Human Genome Sciences Acquired 2013 GlycoVaxyn Acquired 2015 Tesaro Acquired 2019 Sitari Pharmaceuticals Acquired 2019 Sierra Oncology Acquired 2022 Affinivax Acquired 2022 BELLUS Health Inc Acquired 2023 Research areas and products EditFurther information List of GSK plc products Pharmaceuticals Edit GSK manufactures products for major disease areas such as asthma cancer infections diabetes and mental health Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin 82 and amoxicillin clavulanate 83 ticarcillin clavulanate 84 mupirocin 85 and ceftazidime 86 for bacterial infections zidovudine for HIV infection valacyclovir for herpes virus infections albendazole for parasitic infections sumatriptan for migraine lamotrigine for epilepsy bupropion and paroxetine for major depressive disorder cimetidine and ranitidine for gastroesophageal reflux disorder mercaptopurine 87 and thioguanine 88 for the treatment of leukemia allopurinol for gout 89 pyrimethamine for malaria 90 and the antibacterial trimethoprim 88 Among these albendazole amoxicillin amoxicillin clavulanate allopurinol mercaptopurine mupirocin pyrimethamine ranitidine thioguanine trimethoprim and zidovudine are on the World Health Organization s List of Essential Medicines 8 Malaria vaccine Edit In 2014 GSK applied for regulatory approval for the first malaria vaccine 7 Malaria is responsible for over 650 000 deaths annually mainly in Africa 91 Known as RTS S the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates Foundation The company has committed to making the vaccine available in developing countries for five percent above the cost of production 7 As of 2013 update RTS S which uses GSK s proprietary AS01 adjuvant was being examined in a Phase 3 trial in eight African countries PATH reported that i n the 12 month period following vaccination RTS S conferred approximately 50 protection from clinical Plasmodium falciparum disease in children aged 5 17 months and approximately 30 protection in children aged 6 12 weeks when administered in conjunction with Expanded Program for Immunization EPI vaccines 92 In 2014 Glaxo said it had spent more than US 350 million and expected to spend an additional US 260 million before seeking regulatory approval 93 94 Consumer healthcare Edit GSK s consumer healthcare division which earned 5 2 billion in 2013 sells oral healthcare including Aquafresh Macleans and Sensodyne toothpastes GSK also previously owned the Lucozade and Ribena brands of soft drinks but they were sold in 2013 to Suntory for 1 35bn 55 Other products include Abreva to treat cold sores Night Nurse a cold remedy Breathe Right nasal strips and Nicoderm and Nicorette nicotine replacements 95 In March 2014 it recalled Alli an over the counter weight loss drug in the United States and Puerto Rico because of possible tampering following customer complaints 96 Facilities Edit As of 2013 update GSK had offices in over 115 countries and employed over 99 000 people 12 500 in R amp D The company s single largest market is the United States Its US headquarters are in The Navy Yard Philadelphia and Research Triangle Park North Carolina its consumer products division is in Moon Township Pennsylvania 97 COVID 19 vaccine Edit Main article Sanofi GSK COVID 19 vaccine In July 2020 the UK government signed up for 60 million doses of a COVID 19 vaccine developed by GSK and Sanofi It uses a recombinant protein based technology from Sanofi and GSK s pandemic technology The companies claimed to be able to produce one billion doses subject to successful trials and regulatory approval during the first half of 2021 98 The company also agreed to a 2 1 billion deal with the United States to produce 100 million doses of the vaccine 99 Venture arms EditSR One was established in 1985 by SmithKline Beecham to invest in new biotechnology companies and continued operating after GSK was formed by 2003 GSK had formed another subsidiary GSK Ventures to out license or start new companies around drug candidates that it did not intend to develop further 100 As of 2003 update SR One tended to invest only if the company aligned with GSK s business 100 In September 2019 GSK announced it would acquire Sitari Pharmaceuticals and its transglutaminase 2 small molecule program for the treatment of celiac disease 101 Recognition philanthropy and social responsibility EditScientific recognition Edit Four GlaxoSmithKline scientists have been recognized by the Nobel Committee for their contributions to basic medical science and or therapeutics development Henry Dale a former student of Paul Ehrlich received the 1936 Nobel Prize in Medicine for his work on the chemical transmission of neural impulses Dale served as a pharmacologist and then as Director of the Wellcome Physiological Research Laboratories from 1904 to 1914 and later served as Trustee and chairman of the board of the Wellcome Trust 102 John Vane of Wellcome Research Laboratories shared the 1982 Nobel Prize for Medicine for his work on prostaglandin biology and the discovery of prostacyclin Vane served as group research and development director for The Wellcome Foundation from 1973 to 1985 103 Gertrude B Elion and George Hitchings both of the Wellcome Research Laboratories shared the 1988 Nobel Prize in Medicine with Sir James W Black formerly of Smith Kline amp French and the Wellcome Foundation for their discoveries of important principles for drug treatment Elion and Hitchings were responsible for the discovery of a plethora of important drugs including mercaptopurine 87 and thioguanine 88 for the treatment of leukemia the immunosuppressant azothioprine 104 allopurinol for gout 89 pyrimethamine for malaria 90 the antibacterial trimethoprim 88 acyclovir for herpes virus infection 105 and nelarabine for cancer treatment 106 Philanthropy and social responsibility Edit Since 2010 GlaxoSmithKline has several times ranked first among pharmaceutical companies on the Global Access to Medicines Index which is funded by the Bill and Melinda Gates Foundation 107 In 2014 the Human Rights Campaign an LGBT rights advocacy group gave GSK a score of 100 percent in its Corporate Equality Index 108 GSK has been active with the World Health Organization WHO in the Global Alliance to Eliminate Lymphatic Filariasis GAELF Around 120 million people globally are believed to be infected with lymphatic filariasis 109 In 2012 the company endorsed the London Declaration on Neglected Tropical Diseases it agreed to donate 400 million albendazole tablets to the WHO each year to fight soil transmitted helminthiasis and to provide 600 million albendazole tablets every year for lymphatic filariasis until the disease is eradicated 110 As of 2014 update over 5 billion treatments had been delivered and 18 of 73 countries in which the disease is considered endemic had progressed to the surveillance stage 111 In 2009 the company said it would cut drug prices by 25 percent in 50 of the poorest nations release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development and invest 20 percent of profits from the least developed countries in medical infrastructure for those countries 112 113 Medecins Sans Frontieres welcomed the decision but criticized GSK for failing to include HIV patents in its patent pool and for not including middle income countries in the initiative 114 In 2013 GSK licensed its HIV portfolio to the Medicines Patent Pool for use in children and agreed to negotiate a license for dolutegravir an integrase inhibitor then in clinical development 115 In 2014 this license was extended to include dolutegravir and adults with HIV The licenses include countries in which 93 percent of adults and 99 percent of children with HIV live 116 Also in 2013 GSK joined AllTrials a British campaign to ensure that all clinical trials are registered and the results reported The company said it would make its past clinical trial reports available and future ones within a year of the studies end 117 GSK has largely had an access strategy providing medicines at a subsidized price to lower and middle income markets including Africa under the former CEO Andrew Witty In 2017 its new CEO Emma Walmsley 118 shifted away from this with GSK exiting all Sub Saharan African markets and there being no plans to provide its newer expensive oncology and genetics pipeline to this population 119 Controversies Edit1973 Antitrust case over griseofulvin Edit In the 1960s Glaxo Group Ltd Glaxo and Imperial Chemical Industries ICI each owned patents covering various aspects of the antifungal drug griseofulvin 120 54 nn 1 2 121 They created a patent pool by cross licensing their patents subject to express licensing restrictions that the chemical from which the finished form of the drug tablets and capsules was made must not be resold in bulk form and they licensed other drug companies to sell the drug in finished form and subject to similar restrictions 120 54 55 121 The effect and intent of the bulk sale restriction was to keep the drug chemical out of the hands of small companies that might act as price cutters and the effect was to maintain stable uniform prices 122 123 124 The United States brought an antitrust suit against the two companies United States v Glaxo Group Ltd charging them with violation of the Sherman Act and also seeking to have the patents declared invalid 120 55 121 The trial court found that the defendants had engaged in several unlawful conspiracies but dismissed the part of the suit seeking invalidation of patents and refused to grant as relief mandatory sales of the bulk drug chemical and compulsory licensing of the patents 120 56 121 The government appealed to the Supreme Court which reversed in United States v Glaxo Group Ltd 410 U S 52 1973 121 2000s Ribena Edit Old Ribena bottle year unknown made by Beecham Products Brentford Middlesex the label states widely used in hospitals and clinics There were concerns in the 2000s about the sugar and vitamin content of Ribena a blackcurrant based syrup and soft drink owned by GSK until 2013 Produced in England by H W Carter amp Co from the 1930s the company s unbranded syrup was distributed to children as a source of vitamin C during World War II which gave the drink a reputation as good for health Beecham bought H W Carter in 1955 125 In 2001 the British Advertising Standards Authority ASA required GSK to withdraw its claim that Ribena Toothkind a lower sugar variety did not encourage tooth decay A company poster showed bottles of Toothkind in place of the bristles on a toothbrush The ASA s ruling was upheld by the High Court 126 In 2007 GSK was fined US 217 000 in New Zealand over its claim that ready to drink Ribena contained high levels of vitamin C after it was found to contain no detectable vitamin C 127 In 2013 GSK sold Ribena and another drink Lucozade to the Japanese multinational Suntory for 1 35 billion 55 SB Pharmco Puerto Rico Edit In 2010 the US Department of Justice announced that GSK would pay a US 150 million criminal fine and forfeiture and a civil settlement of US 600 million under the False Claims Act The fines stemmed from production of improperly made and adulterated drugs from 2001 to 2005 at GSK s subsidiary SB Pharmco Puerto Rico Inc in Cidra Puerto Rico which at the time produced US 5 5 billion of products each year The drugs involved were Kytril an antiemetic Bactroban used to treat skin infections Paxil the anti depressant and Avandamet a diabetes drug 128 GSK closed the factory in 2009 129 The case began in 2002 when GSK sent experts to fix problems cited by the FDA The lead inspector recommended recalls of defective products but they were not authorised she was fired in 2003 and filed a whistleblower lawsuit In 2005 federal marshals seized US 2 billion worth of products the largest such seizure in history In the 2010 settlement SB Pharmco pleaded guilty to criminal charges and agreed to pay US 150 million in a criminal fine and forfeiture at that time the largest such payment ever by a manufacturer of adulterated drugs and US 600 million in civil penalties to settle the civil lawsuit 129 2010 Pandemrix connected with narcolepsy Edit The Pandemrix influenza vaccine was developed by GlaxoSmithKlinefIn in 2006 It was used by Finland and Sweden in the H1N1 mass vaccination of the population against the 2009 swine flu pandemic In August 2010 The Swedish Medical Products Agency MPA and The Finnish National Institute for Health and Welfare THL launched investigations regarding the development of narcolepsy as a possible side effect to Pandemrix flu vaccination in children 130 and found a 6 6 fold increased risk among children and youths resulting in 3 6 additional cases of narcolepsy per 100 000 vaccinated subjects 131 In February 2011 The Finnish National Institute for Health and Welfare THL concluded that there is a clear connection between the Pandemrix vaccination campaign of 2009 and 2010 and the narcolepsy epidemic in Finland A total of 152 cases of narcolepsy were found in Finland during 2009 2010 and ninety percent of them had received the Pandemrix vaccination 132 133 134 Sweden however observed very few influenza cases totally in 2009 and especially 2010 as compared to most other years 135 In 2015 it was reported that the British Department of Health was paying for Sodium oxybate medication for 80 patients who are taking legal action over problems linked to the use of the swine flu vaccine at a cost to the government of 12 000 per patient per year 136 2012 criminal and civil settlement Edit Overview Edit In July 2012 GSK pleaded guilty in the United States to criminal charges and agreed to pay US 3 billion in what was the largest settlement until then between the Justice Department and a drug company The US 3 billion included a criminal fine of US 956 814 400 and forfeiture of US 43 185 600 The remaining US 2 billion covered a civil settlement with the government under the False Claims Act The investigation was launched largely on the basis of information from four whistleblowers who filed qui tam whistleblower lawsuits against the company under the False Claims Act 9 The charges stemmed from GSK s promotion of the anti depressants Paxil paroxetine and Wellbutrin bupropion for unapproved uses from 1998 to 2003 specifically as suitable for patients under the age of 18 and from its failure to report safety data about Avandia rosiglitazone both in violation of the Federal Food Drug and Cosmetic Act Other drugs promoted for unapproved uses were two inhalers Advair fluticasone salmeterol and Flovent fluticasone propionate as well as Zofran ondansetron Imitrex sumatriptan Lotronex alosetron and Valtrex valaciclovir 9 The settlement also covered reporting false best prices and underpaying rebates owed under the Medicaid Drug Rebate Program and kickbacks to physicians to prescribe GSK s drugs There were all expenses paid spa treatments and hunting trips for doctors and their spouses speakers fees at conferences and payment for articles ghostwritten by the company and placed by physicians in medical journals 9 The company set up a ghostwriting programme called CASPPER initially to produce articles about Paxil but which was extended to cover Avandia 137 As part of the settlement GSK signed a five year corporate integrity agreement with the Department of Health and Human Services which obliged the company to make major changes in the way it did business including changing its compensation programmes for its sales force and executives and to implement and maintain transparency in its research practices and publication policies 9 It announced in 2013 that it would no longer pay doctors to promote its drugs or attend medical conferences and that its sales staff would no longer have prescription targets 138 Rosiglitazone Avandia Edit Further information Rosiglitazone Adverse effects and Rosiglitazone Lawsuits Rosiglitazone The 2012 settlement included a criminal fine of US 242 612 800 for failing to report safety data to the FDA about Avandia rosiglitazone a diabetes drug approved in 1999 and a civil settlement of US 657 million for making false claims about it The Justice Department said GSK had promoted rosiglitazone to physicians with misleading information including that it conferred cardiovascular benefits despite an FDA mandated label warning of cardiovascular risks 9 In 1999 John Buse a diabetes specialist told medical conferences that rosiglitazone might carry an increased risk of cardiovascular problems GSK threatened to sue him called his university head of department and persuaded him to sign a retraction 139 GSK raised questions internally about the drug s safety in 2000 and in 2002 the company ghostwrote an article in Circulation describing a GSK funded clinical trial that suggested rosiglitazone might have a beneficial effect on cardiovascular risk 140 From 2001 reports began to link the thiazolidinediones the class of drugs to which rosiglitazone belongs to heart failure 141 In April that year GSK began a six year open label randomized trial known as RECORD to examine rosiglitazone and cardiovascular events 142 Two GSK meta analyses in 2005 and 2006 showed an increased risk of cardiovascular problems with rosiglitazone the information was passed to the FDA and posted on the company website but not otherwise published By December 2006 rosiglitazone had become the top selling diabetes drug with annual sales of US 3 3 billion 141 In June 2007 The New England Journal of Medicine published a meta analysis that associated the drug with an increased risk of heart attack 143 GSK had reportedly tried to persuade one of the authors Steven Nissen not to publish it after receiving an advance copy from one of the journal s peer reviewers a GSK consultant 144 145 In July 2007 FDA scientists suggested that rosiglitazone had caused 83 000 excess heart attacks between 1999 and 2007 146 4 147 The FDA placed restrictions on the drug including adding a boxed warning but did not withdraw it 148 In 2013 the FDA rejected that the drug had caused excess heart attacks 149 A Senate Finance Committee inquiry concluded in 2010 that GSK had sought to intimidate scientists who had concerns about rosiglitazone 146 In February that year the company tried to halt publication of an editorial about the controversy by Nissen in the European Heart Journal 150 The results of GSK s RECORD trial were published in June 2009 It confirmed an association between rosiglitazone and an increased risk of heart failure and fractures but not of heart attack and concluded that it does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose lowering drugs 142 Steven Nissan and Kathy Wolkski argued that the study s low event rates reduced its statistical power 151 In September 2009 rosiglitazone was suspended in Europe 152 The results of the RECORD study were confirmed in 2013 by the Duke Clinical Research Institute in an independent review required by the FDA 153 In November that year the FDA lifted the restrictions it had placed on the drug 154 The boxed warning about heart attack was removed the warning about heart failure remained in place 149 Paroxetine Paxil Seroxat Edit Main article Study 329 Paroxetine known as Paxil and Seroxat GSK was fined for promoting Paxil Seroxat paroxetine for treating depression in the under 18s although the drug had not been approved for pediatric use 9 Paxil had US 4 97 billion worldwide sales in 2003 155 The company conducted nine clinical trials between 1994 and 2002 none of which showed that Paxil helped children with depression 156 From 1998 to 2003 it promoted the drug for the under 18s paying physicians to go on all expenses paid trips five star hotels and spas 9 From 2004 Paxil s label along with those of similar drugs included an FDA mandated boxed warning that it might increase the risk of suicidal ideation and behaviour in patients under 18 9 An internal SmithKline Beecham document said in 1998 about withheld data from two GSK studies It would be commercially unacceptable to include a statement that pediatric efficacy had not been demonstrated as this would undermine the profile of paroxetine 155 157 The company ghostwrote an article published in 2001 in the Journal of the American Academy of Child and Adolescent Psychiatry that misreported the results of one of its clinical trials Study 329 9 158 The article concluded that Paxil was generally well tolerated and effective for major depression in adolescents 159 The suppression of the research findings is the subject of the 2008 book Side Effects by Alison Bass 160 161 For 10 years GSK marketed Paxil as non habit forming In 2001 35 patients filed a class action suit alleging they had had withdrawal symptoms and in 2002 a Los Angeles court issued an injunction preventing GSK from advertising that the drug was not habit forming 162 The court withdrew the injunction after the FDA objected that the court had no jurisdiction over drug marketing that the FDA had approved 163 In 2003 a World Health Organization committee reported that Paxil was among the top 30 drugs and top three antidepressants for which dependence had been reported 164 n 2 Bupropion Wellbutrin Edit The company was also fined for promoting Wellbutrin bupropion approved at the time for major depressive disorder and also sold as a smoking cessation aid Zyban for weight loss and the treatment of attention deficit hyperactivity disorder sexual dysfunction and substance addiction GSK paid doctors to promote these off label uses and set up supposedly independent advisory boards and Continuing Medical Education programmes 9 China Edit Main article GSK China Scandal In 2013 Chinese authorities announced that since 2007 GSK had funnelled HK 3 8 billion in kickbacks to GSK managers doctors hospitals and others who prescribed their drugs using over 700 travel agencies and consulting firms 165 Chinese authorities arrested four GSK executives as part of a four month investigation into claims that doctors were bribed with cash and sexual favours 166 In 2014 a Chinese court found the company guilty of bribery and imposed a fine of US 490 million Mark Reilly the British head of GSK s Chinese operations received a three year suspended prison sentence after a one day trial held in secret 167 Reilly was reportedly deported from China and dismissed by the company 168 Market manipulation in the UK Edit In February 2016 the company was fined over 37 million in the UK by the Competition and Markets Authority for paying Generics UK Alpharma and Norton Healthcare more than 50m between 2001 and 2004 to keep generic varieties of paroxetine out of the UK market The generics companies were fined a further 8 million At the end of 2003 when generics became available in the UK the price of paroxetine dropped by 70 percent 169 Miscellaneous Edit Italian police sought bribery charges in May 2004 against 4 400 doctors and 273 GSK employees GSK and its predecessor were accused of having spent 152m on physicians pharmacists and others giving them cameras computers holidays and cash Doctors were alleged to have received cash based on the number of patients they treated with a cancer drug topotecan Hycamtin 170 The following month prosecutors in Munich accused 70 100 doctors of having accepted bribes from SmithKline Beecham between 1997 and 1999 The inquiry was opened over allegations that the company had given over 4 000 hospital doctors money and free trips 171 172 All charges were dismissed by the Verona court in January 2009 173 In 2006 in the United States GSK settled the largest tax dispute in IRS history agreeing to pay US 3 1 billion At issue were Zantac and other products sold in 1989 2005 The case revolved around intracompany transfer pricing determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS 174 175 The UK s Serious Fraud Office SFO opened a criminal inquiry in 2014 into GSK s sales practices using powers granted by the Bribery Act 2010 176 The SFO said it was collaborating with Chinese authorities to investigate bringing charges in the UK related to GSK s activities in China Europe and the Middle East 177 Also as of 2014 update the US Department of Justice was investigating GSK with reference to the Foreign Corrupt Practices Act 178 In October 2020 GSK told some staff that while at work they should disable the contact tracing function of the NHS test and trace app which monitors the spread of COVID 19 GSK explained the reason for this was due to social distancing measures in place at their sites rendering the technology unnecessary 179 See also Edit Companies portalList of toothpaste brands Galvani Bioelectronics Index of oral health and dental articles Recherche et Industrie Therapeutiques R I T Notes Edit Glaxo Wellcome was formed from Glaxo s 1995 acquisition of The Wellcome Foundation and SmithKline Beecham from the 1989 merger of the Beecham Group and the SmithKline Beckman Corporation World Health Organization Expert Committee on Drug Dependence 2003 The Committee noted the striking number of reports on paroxetine and withdrawal syndrome The representative of Consumers International reported that a number of patients had experienced difficulty in withdrawing from SSRIs in general It was agreed that withdrawal was indeed a problem in some patients but there was a difference of opinion on the degree of dependence that was involved given the possibility that the need for treatment of resistant or relapsing disease could make these drugs indispensable for patient care The Committee expressed concern about the possibility of inappropriate prescribing resulting in the risk of problems of withdrawal outweighing the benefits of treatment with SSRIs 164 References Edit Full year and fourth quarter 2022 PDF GlaxoSmithKline Retrieved 14 February 2023 New GSK debuts with renewed purpose strategy and brand identity as it says goodbye to consumer business End Points News 9 June 2022 Retrieved 14 February 2023 Headquarters GSK US us gsk com GlaxoSmithKline on the Forbes Top Multinational Performers List Forbes Retrieved 11 December 2017 Global 500 Fortune Retrieved 10 August 2022 FTSE All Share Index Ranking stockchallenge co uk Retrieved 10 August 2022 a b c Plumridge Hester 24 July 2014 Glaxo Files Its Entry in Race for a Malaria Vaccine The Wall Street Journal Lorenzetti Laura 24 July 2014 GlaxoSmithKline seeks approval on first ever malaria vaccine Fortune a b World Health Organization 2019 World Health Organization model list of essential medicines 21st list 2019 Geneva World Health Organization hdl 10665 325771 WHO MVP EMP IAU 2019 06 License CC BY NC SA 3 0 IGO a b c d e f g h i j k GlaxoSmithKline to Plead Guilty and Pay 3 Billion to Resolve Fraud Allegations and Failure to Report Safety Data United States Department of Justice 2 July 2012 Katie Thomas and Michael S Schmidt Glaxo Agrees to Pay 3 Billion in Fraud Settlement The New York Times 2 July 2012 Simon Neville GlaxoSmithKline fined 3bn after bribing doctors to increase drugs sales The Guardian 3 July 2012 R P T Davenport Hines Judy Slinn Glaxo A History to 1962 Cambridge University Press 1992 pp 7 13 David Newton Trademarked A History of Well Known Brands from Airtex to Wright s Coal Tar The History Press 2012 p 435 a b c d David J Ravenscraft William F Long Paths to Creating Value in Pharmaceutical Mergers in Steven N Kaplan ed Mergers and Productivity University of Chicago Press 2000 a b c d e f GSK History GlaxoSmithKline Archived from the original on 8 June 2011 Retrieved 18 April 2011 New Glaxo Company The Times Tuesday 15 October 1935 pg 22 Issue 47195 J Nathan And Glaxo Reorganization The Times Wednesday 8 January 1947 pg 8 Issue 50653 Joseph Nathan amp Co The Times Thursday 20 February 1947 pg 8 Issue 50690 1664 1964 The Story of a Town Tricentennial Committee Addition to Factory The Eastchester Citizen Bulletin 19 November 1924 Peter Pennoyer Anne Walker The Architecture of Delano amp Aldrich W W Norton amp Company 2003 p 188 Iconic Burroughs Wellcome Headquarters Open for Rare Public Tour Archived 28 August 2018 at the Wayback Machine Triangle Modernist Houses press release 8 October 2012 Cummings Alex Sayf 13 June 2016 Into the Spaceship A Visit to the Old Burroughs Wellcome Building Tropics of Meta historiography for the masses Retrieved 25 November 2019 Bouton Katherine 29 January 1989 The Nobel Pair The New York Times Retrieved 12 March 2020 a b Stradling Richard 21 September 2020 United Therapeutics to demolish an RTP landmark building News amp Observer Mark S Lesney The ghosts of pharma past Modern Drug Discovery January 2004 pp 25 26 10 000 face Glaxo s axe at Wellcome The Independent 15 June 1995 Grimond Magnus 21 June 1995 Glaxo warns of redundancies The Independent Archived from the original on 26 February 2014 Grimond Magnus 7 September 1995 Glaxo Wellcome plans to axe 7 500 jobs The Independent Glaxo to Acquire Affymax The New York Times 27 January 1995 Retrieved 12 March 2020 Outlook Glaxo Wellcome The Independent 30 March 1999 Company of the week Glaxo Wellcome The Independent 1 August 1999 Profile Glaxo Wellcome BBC News 17 January 2000 Corely T A B 2011 Beechams 1848 2000 from Pills to Pharmaceuticals Crucible Books ISBN 978 1905472147 Kleinfield N R 29 May 1984 Smithkline One Drug Image The New York Times ISSN 0362 4331 Retrieved 30 September 2019 SmithKline Beckman Corp and International Clinical Laboratories Inc announced UPI Retrieved 30 September 2019 Lohr Steve 13 April 1989 SmithKline Beecham to Merge The New York Times ISSN 0362 4331 Retrieved 30 September 2019 The new alchemy The drug industry s flurry of mergers is based on a big gamble The Economist 20 January 2000 Gershon D May 2000 Partners resolve their differences and unite at the second attempt Nature 405 6783 258 doi 10 1038 35012210 PMID 10821289 S2CID 23140509 Hall that glitters isn t shareholder gold The Daily Telegraph 15 July 2002 Archived from the original on 11 January 2022 GlaxoSmithKline Completes the Purchase of Block Drug for 1 24 Billion PR Newswire Retrieved 1 August 2010 Stouffer Rick 9 October 2006 Glaxo unit buys Breathe Right maker Trib Live Sir Christopher Gent to exit GlaxoSmithKline The Daily Telegraph 28 October 2012 Ben Hirschler 24 May 2007 Glaxo China R amp D centre to target neurodegeneration Reuters Cyranoski David 29 October 2008 Pharmaceutical futures Made in China Nature Corporate Executive Team GlaxoSmithKline Retrieved 16 November 2013 Archived 14 October 2012 at the Wayback Machine Andrew Witty s journey from Graduate to GSK CEO GlaxoSmithKline 12 August 2008 Andrew Philip Witty Bloomberg Ruddick Graham 20 April 2009 GlaxoSmithKline buys Stiefel for 3 6bn The Daily Telegraph Archived from the original on 11 January 2022 FDA Approves Additional Vaccine for 2009 H1N1 Influenza Virus US Food and Drug Administration FDA 16 November 2009 Jack Andrew 16 April 2009 Companies Pharmaceuticals GSK and Pfizer to merge HIV portfolios Financial Times Archived from the original on 10 December 2022 GSK Acquires Laboratorios Phoenix for 253m InfoGrok Sandle Paul 13 December 2010 UPDATE 2 Glaxo buys protein drinks firm Maxinutrition Reuters Ranii David 21 December 2011 GSK sells BC Goody s and other brands News amp Observer Archived from the original on 15 April 2012 GSK confirms 500 mln stg UK investment plans Reuters 22 March 2012 European Biotechnology News 16 May 2012 GSK acquires Cellzome 100 Britain s largest drugmaker GlaxoSmithKline will pay about 75m in cash to acquire Cellzome AG completely Archived 4 June 2016 at the Wayback Machine John Carroll for FierceBiotech 15 May 2012 GSK snags proteomics platform tech in 98M Cellzome buyout John Carroll for FiercePharma 12 June 2012 GSK continues deal spree with 302M pact for Basilea eczema drug Basilea Pharmaceutica Press Release 11 June 2012 Basilea enters into global agreement with Stiefel a GSK company for Toctino alitretinoin Matthew Herper Three Lessons From GlaxoSmithKline s Purchase Of Human Genome Sciences Forbes 16 July 2012 a b c Angela Monaghan Ribena and Lucozade sold to Japanese drinks giant The Guardian 9 September 2013 Hirschler Ben 10 March 2014 GSK pays 1 billion to lift Indian unit stake to 75 percent Reuters Retrieved 10 March 2014 Bray Chad Jolly David 23 April 2014 Novartis and Glaxo Agree to Trade 20 Billion in Assets The New York Times Retrieved 12 March 2020 Rockoff Jonathan D Whalen Jeanne Falconi Marta 22 April 2014 Deal Flurry Shows Drug Makers Swing Toward Specialization The Wall Street Journal Retrieved 12 March 2020 GEN News Highlights GSK Acquires GlycoVaxyn for 190M GEN 11 February 2015 Pfizer Buys Two GSK Meningitis Vaccines for 130M GEN 22 June 2015 Retrieved 25 March 2016 James Quinn Sir Philip Hampton to chair Glaxo The Daily Telegraph 25 September 2014 Herper Matthew GlaxoSmithKline Appoints Big Pharma s First Woman Chief Executive Forbes Retrieved 11 December 2017 Yeomans Jon 20 September 2016 Emma Walmsley becomes latest female CEO in FTSE 100 as she replaces Sir Andrew Witty at GSK The Telegraph Daily Telegraph London Archived from the original on 21 September 2016 Retrieved 20 September 2016 GlaxoSmithKline boosts stake in Saudi Arabia unit Reuters 18 December 2017 a b GlaxoSmithKline considers splitting up the group FT Reuters 21 July 2018 Retrieved 23 July 2018 a b Gruber Kane Wu 28 November 2018 Unilever in pole position to swallow GSK s Indian Horlicks business Reuters Retrieved 28 November 2018 GlaxoSmithKline taps Unilever as lead bidder in Indian Horlicks buyout report FiercePharma Retrieved 28 November 2018 Unilever swallows GSK s Indian Horlicks business for 3 8 billion Reuters 3 December 2018 Retrieved 3 December 2018 GSK slides after buying cancer firm Tesaro for hefty 5 1 billion Reuters 3 December 2018 Retrieved 3 December 2018 Sagonowsky Eric 21 October 2019 Zeroing in on fast growing vaccines GSK sheds 2 shots to Bavarian Nordic for up to 1 1B FiercePharma Archived from the original on 5 January 2020 Retrieved 26 January 2020 GSK agrees to divest rabies and tick borne encephalitis vaccines to Bavarian Nordic gsk com Retrieved 26 January 2020 Schuetze Pushkala Aripaka 20 July 2020 GSK buys 10 of CureVac in vaccine tech deal Reuters via uk reuters com GSK buys out Novartis in 13 billion consumer healthcare shake up Reuters 27 March 2018 Retrieved 27 March 2018 a b Drugmaker GSK to split after striking Pfizer consumer health deal Reuters 19 December 2018 Retrieved 19 December 2018 Hello Haleon GlaxoSmithKline reveals name of 60bn consumer health spin out Evening Standard 22 February 2022 Retrieved 23 February 2022 Cavale Siddharth Burger Ludwig Dey Mrinmay 15 January 2022 GSK rejects 50 billion pound Unilever offer for consumer assets Reuters via www reuters com Pfizer to exit GSK consumer health joint venture after London listing Financial Times 1 June 2022 Archived from the original on 10 December 2022 Retrieved 15 June 2022 Grover Natalie Shabong Yadarisa 13 April 2022 GSK to buy Sierra Oncology amid pressure to boost drug pipeline Reuters via www reuters com GSK Bolsters Vaccines Business with 3 3B Affinivax Buy Biospace 31 May 2022 Retrieved 9 June 2022 Change of name London Stock Exchange 16 May 2022 Retrieved 2 June 2022 GSK To Acquire The Late stage Biopharmaceutical Group For 14 75 Per Share MarketWatch Retrieved 18 April 2023 Most recognized brands Anti infectives December 2013 Drugs com Geddes AM Klugman KP Rolinson GN December 2007 Introduction historical perspective and development of amoxicillin clavulanate Int J Antimicrob Agents 30 Suppl 2 S109 12 doi 10 1016 j ijantimicag 2007 07 015 PMID 17900874 Brown AG August 1986 Clavulanic acid a novel beta lactamase inhibitor a case study in drug discovery and development Drug Des Deliv 1 1 1 21 PMID 3334541 mupirocin search results DailyMed Retrieved 12 March 2020 Richards DM Brogden RN February 1985 Ceftazidime A review of its antibacterial activity pharmacokinetic properties and therapeutic use Drugs 29 2 105 61 doi 10 2165 00003495 198529020 00002 PMID 3884319 a b 6 Mercaptopurine Chemical amp Engineering News a b c d George Hitchings and Gertrude Elion Science History Institute June 2016 a b Elion GB 1989 The purine path to chemotherapy Science 244 4900 41 7 Bibcode 1989Sci 244 41E doi 10 1126 science 2649979 PMID 2649979 a b Altman Lawrence K 23 February 1999 Gertrude Elion Drug Developer Dies at 81 The New York Times Press release Malaria vaccine candidate reduces disease over 18 months of follow up in late stage study of more than 15 000 infants and young children PATH Birkett AJ Moorthy VS Loucq C et al April 2013 Malaria vaccine R amp D in the Decade of Vaccines breakthroughs challenges and opportunities Vaccine 31 Supplement 2 B233 43 doi 10 1016 j vaccine 2013 02 040 PMID 23598488 Malaria vaccine candidate reduces disease over 18 months of follow up in late stage study of more than 15 000 infants and young children GlaxoSmithKline Archived from the original on 7 April 2014 McNeil Donald G Jr 18 October 2011 Scientists See Promise in Vaccine for Malaria The New York Times Majumdar Ramanuj 2007 Product management in India 3rd ed PHI Learning p 242 ISBN 978 81 203 3383 3 Aaron Smith Alli weight loss drug recalled for tampering CNN 27 March 2014 About us what we do GlaxoSmithKline accessed 16 November 2013 Archived 13 October 2013 at the Wayback Machine Coronavirus vaccine UK signs deal with GSK and Sanofi BBC News 29 July 2020 U S agrees to pay Sanofi and GSK 2 1 billion for 100 million doses of coronavirus vaccine CNBC 31 July 2020 a b Reaume Andrew 1 January 2003 Is Corporate Venture Capital a Prescription for Success in the Pharmaceutical Industry The Journal of Private Equity 6 4 77 87 doi 10 3905 jpe 2003 320058 JSTOR 43503355 S2CID 154182967 GSK to Acquire Celiac Focused Sitari Pharmaceuticals BioSpace The Nobel Prize in Physiology or Medicine 1936 NobelPrize org The Nobel Prize in Physiology or Medicine 1982 NobelPrize org Maltzman JS Koretzky GA April 2003 Azathioprine old drug new actions J Clin Invest 111 8 1122 4 doi 10 1172 JCI18384 PMC 152947 PMID 12697731 Elion GB 1993 Acyclovir discovery mechanism of action and selectivity J Med Virol Suppl 1 2 6 doi 10 1002 jmv 1890410503 PMID 8245887 S2CID 37848199 Koenig R 2006 The legacy of great science the work of Nobel Laureate Gertrude Elion lives on Oncologist 11 9 961 5 doi 10 1634 theoncologist 11 9 961 PMID 17030634 Access to medicine PDF Archived from the original PDF on 7 February 2014 Human Rights Campaign Profile Buyers Guide entry for GlaxoSmithKline Archived 13 May 2016 at the Wayback Machine Accessed 16 May 2014 Global alliance to eliminate Lymphatic Filariasis Ifpma org Archived from the original on 27 December 2008 Private and Public Partners Unite to Combat 10 Neglected Tropical Diseases by 2020 Bill amp Melinda Gates Foundation 30 January 2012 Archived from the original on 14 March 2013 Retrieved 30 May 2013 Research based pharma pledges on neglected tropical diseases The Pharma Letter 31 January 2012 Global programme to eliminate lymphatic filariasis progress report 2014 PDF World Health Organization 18 September 2015 p 490 Sarah Boseley Drug giant GlaxoSmithKline pledges cheap medicine for world s poor The Guardian 13 February 2009 UNITAID 16 February 2009 UNITAID Statement on GSK Patent Pool For Neglected Diseases Archived 27 May 2014 at the Wayback Machine Tido von Schoen Angerer Letter to the editor The Guardian 16 February 2009 GlaxoSmithKline unit joins patent pool for AIDS drugs Reuters Reuters 27 February 2013 Medicines Patent Pool ViiV Healthcare Sign Licence for the Most Recent HIV Medicine to Have Received Regulatory Approval Medicines Patent Pool Ben Goldacre Bad Pharma Fourth Estate 2013 2012 p 387 Palmer Eric 17 January 2018 GSK cutting jobs in sub Saharan Africa will rely on distributors Fierce Pharma Retrieved 10 January 2023 GSK stops Nairobi production as high costs and low sales eat into revenue The East African 15 October 2022 Retrieved 9 March 2023 a b c d United States v Glaxo Group Ltd 410 U S 52 1973 a b c d e LaHatte Gabrielle 2011 Reverse Payments When the Federal Trade Commission can Attack the Validity of Underlying Patents Case Western Reserve Journal of Law Technology amp the Internet 2 37 73 Retrieved 19 June 2015 Leslie Christopher R 2011 Antitrust Law and Intellectual Property Rights Cases and Materials Oxford University Press pp 574 75 ISBN 9780195337198 United States v Glaxo Group Ltd at 62 63 Jacobson Jonathan M 2007 Antitrust Law Developments American Bar Association p 1162 ISBN 9781590318676 Oliver Thring Consider squash and cordial The Guardian 7 September 2010 We have Frank and Vernon to thank for Ribena Archived 18 April 2015 at the Wayback Machine The Bristol Post 17 September 2013 Linus Gregoriadis Makers of Ribena lose fight over anti decay claims The Daily Telegraph 18 January 2001 Eames David 28 March 2007 Judge orders Ribena to fess up The New Zealand Herald Tony Jaques When an Icon Stumbles The Ribena Issue Mismanaged Archived 4 March 2016 at the Wayback Machine Corporate Communications An International Journal 13 4 2008 pp 394 406 Michael Regester Judy Larkin Risk Issues and Crisis Management in Public Relations Kogan Page Publishers 2008 p 67ff GlaxoSmithKline to Plead Guilty amp Pay 750 Million to Resolve Criminal and Civil Liability Regarding Manufacturing Deficiencies at Puerto Rico Plant U S Department of Justice 26 October 2010 a b Harris Gardiner Wilson Duff 26 October 2010 Glaxo to Pay 750 Million for Sale of Bad Products The New York Times The MPA investigates reports of narcolepsy in patients vaccinated with Pandemrix The Swedish Medical Products Agency 18 August 2010 Retrieved 19 August 2010 Report from an epidemiological study in Sweden on vaccination with Pandemrix and narcolepsy Swedish medical product agency 30 June 2011 THL Pandemrixilla ja narkolepsialla on selva yhteys Mtv3 fi Retrieved 8 September 2018 Terveyden ja hyvinvoinnin laitos THL Terveyden ja hyvinvoinnin laitos Archived from the original on 5 September 2012 Retrieved 8 September 2018 Narkolepsia ja sikainfluenssarokote THL Terveyden ja hyvinvoinnin laitos Archived from the original on 17 May 2013 Retrieved 8 September 2018 Statistikdatabas for dodsorsaker den oppna delen av dodsorsaksregistret in Swedish Socialstyrelsen Retrieved 24 March 2020 diagnoskod J09 J10 och J11 DH funds private prescriptions for drug denied to NHS patients Health Service Journal 20 July 2015 Retrieved 20 July 2015 Max Baucus Chuck Grassley Finance Committee Letter to the FDA Regarding Avandia United States Senate Finance Committee 12 July 2010 Jim Edwards Inside GSK s CASSPER Ghostwriting Program CBS News 21 August 2009 GSK to stop paying doctors in major marketing overhaul Archived 28 October 2014 at the Wayback Machine Thomson Reuters 17 December 2013 The Intimidation of Dr John Buse and the Diabetes Drug Avandia Committee on Finance United States Senate November 2007 pp 2 4 Max Baucus Chuck Grassley Finance Committee Letter to the FDA Regarding Avandia United States Senate Finance Committee 12 July 2010 for internal concerns p 2 and attachment E pp 20 35 for ghostwriting p 3 and attachment H pp 58 109 for the ghostwriting attachment I p 110ff for cover letter to Circulation attachment I p 143 for the ghostwritten article attachment I pp 152 158 Haffner SM Greenberg AS Weston WM et al August 2002 Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus Circulation 106 6 679 84 doi 10 1161 01 CIR 0000025403 20953 23 PMID 12163427 a b Nissen SE April 2010 The rise and fall of rosiglitazone European Heart Journal 31 7 773 776 doi 10 1093 eurheartj ehq016 PMID 20154334 see table 1 for timeline a b Home PD Pocock SJ Beck Nielsen H et al June 2009 Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes RECORD a multicentre randomised open label trial Lancet 373 9681 2125 35 doi 10 1016 S0140 6736 09 60953 3 PMID 19501900 S2CID 25939495 Home PD Pocock SJ Beck Nielsen H et al September 2005 Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes RECORD study design and protocol Diabetologia 48 9 1726 35 doi 10 1007 s00125 005 1869 1 PMID 16025252 RECORD Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes Full Text View ClinicalTrials gov 21 March 2017 Retrieved 12 March 2020 Nissen SE Wolski K 2007 Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes New England Journal of Medicine 356 24 2457 71 doi 10 1056 NEJMoa072761 PMID 17517853 Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that had borderline significance Saul Stephanie 30 January 2008 Doctor Accused of Leak to Drug Maker The New York Times Retrieved 12 March 2020 Harris Gardiner 22 February 2010 A Face Off on the Safety of a Drug for Diabetes The New York Times Retrieved 12 March 2020 a b Staff report on GlaxoSmithKline and the diabetes drug Avandia Committee on Finance United States Senate January 2010 Grassley Baucus Release Committee Report on Avandia The United States Senate Committee on Finance 20 February 2010 Andrew Clark Glaxo s handling of Avandia concerns damned by US Senate committee The Guardian 22 February 2010 David Graham Assessment of the cardiovascular risks and health benefits of rosiglitazone Office of Surveillance and Epidemiology Food and Drug Administration 30 July 2007 FDA Adds Boxed Warning for Heart related Risks to Anti Diabetes Drug Avandia Agency says drug to remain on market while safety assessment continues Food and Drug Administration 14 November 2007 a b FDA Drug Safety Communication FDA requires removal of some prescribing and dispensing restrictions for rosiglitazone containing diabetes medicines Food and Drug Administration 25 November 2013 Avandia Prescribing information Food and Drug Administration Thomas F Luscher Ulf Landmesser Frank Ruschitzka 23 April 2010 Standing firm the European Heart Journal scientific controversies and the industry European Heart Journal 31 10 1157 1158 doi 10 1093 eurheartj ehq127 Nissen SE April 2010 The rise and fall of rosiglitazone Eur Heart J 31 7 773 6 doi 10 1093 eurheartj ehq016 PMID 20154334 Slaoui M 2010 The rise and fall of rosiglitazone reply Eur Heart J 31 10 1282 4 doi 10 1093 eurheartj ehq118 PMID 20499440 Komajda M McMurray JJ Beck Nielsen H Gomis R Hanefeld M Pocock SJ Curtis PS Jones NP Home PD 2010 Heart failure events with rosiglitazone in type 2 diabetes data from the RECORD clinical trial Eur Heart J 31 7 824 31 doi 10 1093 eurheartj ehp604 PMC 2848325 PMID 20118174 Nissen Steven E Wolski Kathy July 2010 Rosiglitazone RevisitedAn Updated Meta analysis of Risk for Myocardial Infarction and Cardiovascular Mortality Archives of Internal Medicine 170 14 1191 1202 doi 10 1001 archinternmed 2010 207 PMID 20656674 That study was limited by low event rates which resulted in insufficient statistical power to confirm or refute evidence of an increased risk for ischemic myocardial events European Medicines Agency recommends suspension of Avandia Avandamet and Avaglim European Medicines Agency 23 September 2010 McHaffey Kenneth W et al 2013 Results of a reevaluation of cardiovascular outcomes in the RECORD trial American Heart Journal 166 2 240 249 doi 10 1016 j ahj 2013 05 004 PMID 23895806 FDA requires removal of certain restrictions on the diabetes drug Avandia Food and Drug Administration 25 November 2013 Readjudication of the Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycemia in Diabetes Trial RECORD Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee Food and Drug Administration 5 6 June 2013 Steven Nissen Steven Nissen The Hidden Agenda Behind The FDA s New Avandia Hearings Forbes 23 May 2013 The FDA Responds To Steve Nissen s Criticism Of Upcoming Avandia Meeting Forbes 23 May 2013 a b W Kondro B Sibbald March 2004 Drug company experts advised staff to withhold data about SSRI use in children Canadian Medical Association Journal 170 5 783 doi 10 1503 cmaj 1040213 PMC 343848 PMID 14993169 Goldacre 2013 p 58 Samson Kurt December 2008 Senate probe seeks industry payment data on individual academic researchers Annals of Neurology 64 6 A7 9 doi 10 1002 ana 21271 PMID 19107985 S2CID 12019559 Letter showing authorship of Study 239 Drug Industry Document Archive University of California San Francisco Isabel Heck Controversial Paxil paper still under fire 13 years later The Brown Daily Herald 2 April 2014 Jureidini Jon N McHenry Leemon B Mansfield Peter R 2008 Clinical trials and drug promotion Selective reporting of study 329 International Journal of Risk amp Safety in Medicine 20 1 2 73 81 doi 10 3233 JRS 2008 0426 Company hid suicide link BBC News 29 January 2007 Secrets of the Drug Trials BBC Panorama 29 January 2007 Goldacre 2013 pp 296 297 Keller Martin et al July 2001 Efficacy of paroxetine in the treatment of adolescent major depression a randomized controlled trial PDF Journal of the American Academy of Child and Adolescent Psychiatry 40 7 762 772 doi 10 1097 00004583 200107000 00010 PMID 11437014 Alison Bass 2008 Side Effects A Prosecutor a Whistleblower and a Bestselling Antidepressant on Trial Algonquin Books of Chapel Hill Angell Marcia 15 January 2009 Drug Companies amp Doctors A Story of Corruption The New York Review of Books Vol 56 no 1 Judge Paxil ads can t say it isn t habit forming Associated Press 20 August 2002 Drug and Device Law 14 December 2006 The FDA s Amicus Briefs on Preemption Ronald D White for the Los Angeles Times 21 August 2002 U S Opposes Order to Pull Paxil TV Ads a b WHO Expert Committee on Drug Dependence Thirty third Report World Health Organization 2003 pp 20 25 Alice Yan Toh Han Shih 16 July 2013 Shanghai travel agent s revenue surge led to arrests in GSK bribery case South China Morning Post GlaxoSmithKline executives face China bribery probe BBC News 11 July 2013 Rupert Neate and Angela Monaghan GlaxoSmithKline admits some staff in China involved in bribery The Guardian 22 July 2013 Rupert Neate GSK s China crisis chief executive Andrew Witty speaks as it happened The Guardian 24 July 2013 Philips Tom 26 July 2013 Chinese police allege Glaxo sales reps trained to offer sexual bribes The Daily Telegraph Archived from the original on 11 January 2022 Bradsher Keith Buckley Chris 19 September 2014 China Fines GlaxoSmithKline Nearly 500 Million in Bribery Case The New York Times Malcolm Moore Denise Roland China fines Glaxo 297m for bribery Mark Reilly sentenced The Daily Telegraph 19 September 2014 Bradshaw Julia 12 February 2016 Watchdog fines GSK 37m for paying to keep generic drugs out of UK market The Daily Telegraph Archived from the original on 11 January 2022 Hooper John Stewart Heather 27 May 2004 Over 4 000 doctors face charges in Italian drugs scandal The Guardian Retrieved 31 August 2022 Burgermeister J 2004 German prosecutors probe again into bribes by drug companies BMJ 328 7452 1333 doi 10 1136 bmj 328 7452 1333 a PMC 420312 PMID 15178593 Glaxo probed over doctor freebies BBC News 12 March 2002 Retrieved 31 August 2022 GlaxoSmithKline Annual Report 2008 PDF p 177 Retrieved 8 October 2015 GlaxoSmithKline to Settle Tax Dispute With U S Reuters 12 September 2006 IRS Accepts Settlement Offer in Largest Transfer Pricing Dispute IRS 11 September 2006 Kollewe Julia 28 May 2014 GlaxoSmithKline faces criminal investigation by Serious Fraud Office The Guardian Ridley Kirstin 23 July 2014 UK fraud office liaising with China on GSK bribery case Reuters Retrieved 31 August 2022 GlaxoSmithKline faces bribery claims in Syria The Telegraph Reuters 12 August 2014 Retrieved 31 August 2022 Davies Rob 6 October 2020 GSK tells UK staff turn off Covid test and trace app while at work TheGuardian com Retrieved 6 October 2020 External links EditOfficial website Business data for GSK plc BloombergGoogleReutersSEC filingsYahoo GSK plc companies grouped at OpenCorporates Retrieved from https en wikipedia org w index php title GSK plc amp oldid 1151680475, wikipedia, wiki, book, books, library,

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