Transsexual

"Transsexuality" redirects here. Not to be confused with transgender sexuality.

Transsexual people experience a gender identity that is inconsistent with their assigned sex, and desire to permanently transition to the sex or gender with which they identify, usually seeking medical assistance (including sex reassignment therapies, such as hormone replacement therapy and sex reassignment surgery) to help them align their body with their identified sex or gender.

Transsexual woman July Schultz displaying her palm with the letters "XY" written on it at an outdoor demonstration.^[1]

The term transsexual is a subset of transgender,^[2][3] but some transsexual people reject the label of transgender.^{[4][5][6][7]: 8, 34, 120–121} A medical diagnosis of gender dysphoria can be made if a person experiences marked and persistent incongruence between their gender identity and their assigned sex.^[8]

Understanding of transsexual people has changed very quickly in the 21st century. Many 20th century medical beliefs and practices around transsexual people are now considered deeply outdated. Transsexual people were once classified as mentally ill and subject to extensive gatekeeping by the medical establishment, and remain so in much of the developing world.^{[9][10][11][12]}

Terminology

See also: Transgender § Terminology

Transsexual has had different meanings throughout time. In modern usage, it refers to "a person who desires to or who has modified their body to transition from one gender or sex to another through the use of medical technologies such as hormones or surgeries." Within the transgender community, the term is a subject of debate, and it is sometimes considered an antiquated or pejorative term. The more widely preferred terms are transgender or the abbreviated form trans. However, due to its historical usage, continued usage in the medical community, and continued self-identification with the term by some people, transsexual remains in the modern vernacular.^{[13]: 742–744}

In understanding the subject, it is noted that there is a difference between gender and sex. Gender is defined as a "set of social, cultural, and linguistic norms that can be attributed to someone's identity, expression, or role as masculine, feminine, androgynous, or nonbinary." Sex is defined as being "assigned at birth by medical professionals based on the appearance of genitalia, and related assumptions about chromosomal makeup, gender identity, expressions, and roles emerge over the life span, sometimes changing over time."^{[13]: 277–278}

Origins

Norman Haire reported that in 1921 Dora Richter of Germany began a surgical transition, under the care of Magnus Hirschfeld, which ended in 1930 with a successful genital reassignment surgery (GRS).^[14] In 1930, Hirschfeld supervised the second genital reassignment surgery to be reported in detail in a peer-reviewed journal, that of Lili Elbe of Denmark. In 1923, Hirschfeld introduced the (German) term "Transsexualismus",^[15] after which David Oliver Cauldwell introduced "transsexualism" and "transsexual" to English in 1949 and 1950.^[16][17]

Cauldwell appears to be the first to use the term to refer to those who desired a change of physiological sex.^[18] In 1969, Harry Benjamin claimed to have been the first to use the term "transsexual" in a public lecture, which he gave in December 1953.^[19] Benjamin went on to popularize the term in his 1966 book, The Transsexual Phenomenon, in which he described transsexual people on a scale (later called the "Benjamin scale") of three levels of intensity: "Transsexual (nonsurgical)", "Transsexual (moderate intensity)", and "Transsexual (high intensity)".^[20][21][22]

Relationship to transgender

The term transgender was coined by John Oliven in 1965.^[2] By the 1990s, transsexual had come to be considered a subset of the umbrella term transgender.^[23][2][3] The term transgender is now more common, and many transgender people prefer the designation transgender and reject transsexual.^[24][25][26] Some people who pursue medical assistance (for example, sex reassignment surgery) to change their sexual characteristics to match their gender identity prefer the designation transsexual and reject transgender.^[24][25][26] One perspective offered by transsexual people who reject a transgender label for that of transsexed is that, for people who have gone through sexual reassignment surgery, their anatomical sex has been altered, whilst their gender remains constant.^[27][28][29]

Historically, one reason some people preferred transsexual to transgender is that the medical community in the 1950s through the 1980s encouraged a distinction between the terms that would only allow the former access to medical treatment.^[30] Other self-identified transsexual people state that those who do not seek sex reassignment surgery (SRS) are fundamentally different from those who do, and that the two have different concerns,^[22] but this view is controversial, and others argue that merely having some medical procedures does not have such far-reaching consequences as to put those who have them and those who have not (e.g. because they cannot afford them) into such distinctive categories. Some have objected to the term transsexual on the basis that it describes a condition related to gender identity rather than sexuality.^{[31][better source needed]} For example, Christine Jorgensen, the first person widely known in the United States for having had sex reassignment surgery (in this case, male-to-female), rejected transsexual and instead identified herself in newsprint as trans-gender, on this basis.^[32][33]

A common argument in opposition to the term transsexual is that it over-medicalizes the trans experience, and/or focuses too much on diagnosis.^{[13]: 742–744} The term transgender emerged in part in an attempt to break the "medical monopoly" on transitioning that transsexual implied.^[34]

GLAAD's media reference guide offers the following distinction on the use of transsexual:^[35]

An older term that originated in the medical and psychological communities. As the gay and lesbian community rejected homosexual and replaced it with gay and lesbian, the transgender community rejected transsexual and replaced it with transgender. Some people within the trans community may still call themselves transsexual. Do not use transsexual to describe a person unless it is a word they use to describe themself. If the subject of your news article uses the word transsexual to describe themself, use it as an adjective: transsexual woman or transsexual man.

Terminological variance

The word transsexual is most often used as an adjective rather than a noun – a "transsexual person" rather than simply "a transsexual".^{[citation needed]} As of 2018^[update], use of the noun form (e.g. referring to people as transsexuals) was often deprecated by those in the transsexual community.^[36] Like other trans people, transsexual people prefer to be referred to by the gender pronouns and terms associated with their gender identity. For example, a trans man is a person who was assigned the female sex at birth on the basis of his genitals, but despite that assignment, identifies as a man and is transitioning or has transitioned to a male gender role; in the case of a transsexual man, he furthermore has or will have a masculine body. Transsexual people are sometimes referred to with directional terms, such as "female-to-male" for a transsexual man, abbreviated to "F2M", "FTM", and "F to M", or "male-to-female" for a transsexual woman, abbreviated "M2F", "MTF" and "M to F".

Individuals who have undergone and completed sex reassignment surgery are sometimes referred to as transsexed individuals;^[37] however, the term transsexed is not to be confused with the term transsexual, which can also refer to individuals who have not yet undergone SRS, and whose anatomical sex (still) does not match their psychological sense of personal gender identity.

A rarer, alternate spelling for transsexual has been transexual, with a single S. This variation is British in origin. This spelling was used by The Transexual Menace, an activist group, for example.^[13]: 738 This spelling has been used by some activists in an attempt to remove "pathologizing implications" from their use of the word.^[7]: 25 Another rare variation, a synonym for transsexual, is transsex.^[38]

The terms gender dysphoria and gender identity disorder were not used until the 1970s,^[39] when Laub and Fisk published several works on transsexualism using these terms.^[40][41] "Transsexualism" was replaced in the DSM-IV by "gender identity disorder in adolescents and adults".

Male-to-female transsexualism has sometimes been called "Harry Benjamin's syndrome" after the endocrinologist who pioneered the study of dysphoria.^[42] As the present-day medical study of gender variance is much broader than Benjamin's early description, there is greater understanding of its aspects,^[43] and use of the term Harry Benjamin's syndrome has been criticized for delegitimizing gender-variant people with different experiences.^{[44][page needed][45][page needed]}

Sexual orientation

Main article: Androphilia and gynephilia

See also: Transgender § Sexual orientation of transgender people

Since the middle of the 20th century, homosexual transsexual and related terms were used to label individuals' sexual orientation based on their birth sex.^[46] Many sources criticize this choice of wording as confusing, "heterosexist",^[47] "archaic",^{[48][failed verification]} and demeaning because it labels people by sex assigned at birth instead of their gender identity.^{[49][page needed]} Sexologist John Bancroft also recently expressed regret for having used this terminology, which was standard when he used it, to refer to transsexual women.^[50] He says that he now tries to choose his words more sensitively.^[50] Sexologist Charles Allen Moser is likewise critical of the terminology.^[51] Sociomedical scientist Rebecca Jordan-Young challenges researchers like Simon LeVay, J. Michael Bailey, and Martin Lalumiere, who she says "have completely failed to appreciate the implications of alternative ways of framing sexual orientation."^{[52][page needed]}

The terms androphilia and gynephilia to describe a person's sexual orientation without reference to their gender identity were proposed and popularized by psychologist Ron Langevin in the 1980s.^{[53][page needed]} The similar specifiers attracted to men, attracted to women, attracted to both or attracted to neither were used in the DSM-IV.^[54]

Many transsexual people choose the language of how they refer to their sexual orientation based on their gender identity, not their birth assigned sex.^[43]

Surgical status

Several terms are in common use, especially within the community itself relating to the surgical or operative status of someone who is transsexual, depending on whether they have already had sex reassignment surgery (SRS), have not had SRS but still intend to, or do not intend to have SRS. They are, post-op, pre-op, and non-op, respectively.^[55]

Pre-operative

A pre-operative transsexual person, or simply pre-op for short, is someone who intends to have SRS at some point, but has not yet had it.^[55][56]

Post-operative

A post-operative transsexual person, or post-op for short, is someone who has had SRS.^[55]

Non-operative

A non-operative transsexual person, or non-op, is someone who has not had SRS, and does not intend to have it in the future. There can be various reasons for this, from personal to financial.^[55] Having SRS is not a requirement of being transsexual. Evolutionary biologist and trans woman Julia Serano criticizes the societal preoccupation with SRS as phallocentric, objectifying of transsexuals, and an invasion of privacy.^{[57]: 229–231}

Historical understanding

This section is transcluded from Transgender. (edit | history)

Transgender people are known to have existed since ancient times. A wide range of societies had traditional third gender roles, or otherwise accepted trans people in some form.^[58] However, a precise history is difficult because the modern concept of being transgender, and gender in general, did not develop until the mid-1900s. Historical understandings are thus inherently filtered through modern principles, and were largely viewed through a medical lens until the late 1900s.^[59]The Hippocratic Corpus (interpreting the writing of Herodotus) describes the "disease of the Scythians" (regarding the Enaree), which it attributes to impotency due to riding on a horse without stirrups. This reference was well discussed by medical writings of the 1500s–1700s. Pierre Petit writing in 1596 viewed the "Scythian disease" as natural variation, but by the 1700s writers viewed it as a "melancholy", or "hysterical" psychiatric disease. By the early 1800s, being transgender separate from Hippocrates' idea of it was claimed to be widely known, but remained poorly documented. Both trans women and trans men were cited in European insane asylums of the early 1800s. One of the earliest recorded transgender people in America was Thomas(ine) Hall, a seventeenth century colonial servant.^[60] The most complete account of the time came from the life of the Chevalier d'Éon (1728–1810), a French diplomat. As cross-dressing became more widespread in the late 1800s, discussion of transgender people increased greatly and writers attempted to explain the origins of being transgender. Much study came out of Germany, and was exported to other Western audiences. Cross-dressing was seen in a pragmatic light until the late 1800s; it had previously served a satirical or disguising purpose. But in the latter half of the 1800s, cross-dressing and being transgender became viewed as an increasing societal danger.^[61]

William A. Hammond wrote an 1882 account of transgender Pueblo "shamans" [sic] (mujerados), comparing them to the Scythian disease. Other writers of the late 1700s and 1800s (including Hammond's associates in the American Neurological Association) had noted the widespread nature of transgender cultural practices among native peoples. Explanations varied, but authors generally did not ascribe native transgender practices to psychiatric causes, instead condemning the practices in a religious and moral sense. Native groups provided much study on the subject, and perhaps the majority of all study until after WWII.^[61]

Critical studies first began to emerge in the late 1800s in Germany, with the works of Magnus Hirschfeld. Hirschfeld coined the term "transvestite" in 1910 as the scope of transgender study grew. His work would lead to the 1919 founding of the Institut für Sexualwissenschaft in Berlin. Though Hirscheld's legacy is disputed, he revolutionized the field of study. The Institut was destroyed when the Nazis seized power in 1933, and its research was infamously burned in the May 1933 Nazi book burnings.^[62] Transgender issues went largely out of the public eye until after World War II. Even when they re-emerged, they reflected a forensic psychology approach, unlike the more sexological that had been employed in the lost German research.^[61][63]

20th century medical understanding

Although there are records of sex reassignment surgery (SRS) going back to the 2nd century, the first modern types of such practice first appeared in the 20th century.^[64][65] In this context, Harry Benjamin suggested that moderate intensity male to female transsexual people may benefit from estrogen medication as a "substitute for or preliminary to operation."^[20] In Benjamin's view, people may have had sex reassignment surgery even though they do not meet the definition of transsexual,^{[citation needed]} while others do not desire SRS although they fit his definition of a "true transsexual".^{[citation needed]} "Transsexuality" was included for the first time in the DSM-III in 1980 and again in the DSM-III-R in 1987, where it was located under Disorders Usually First Evident in Infancy, Childhood or Adolescence.

Beyond Benjamin's work, which focused on male-to-female (MTF) transsexual people, there are cases of the female to male transsexual, for whom genital surgery may not be practical. Benjamin gave certifying letters to his MTF transsexual patients that stated "Their anatomical sex, that is to say, the body, is male. Their psychological sex, that is to say, the mind, is female." Starting in 1968 Benjamin abandoned his early terminology and adopted that of "gender identity."^[43]

Medical diagnosis

Transsexualism is no longer classified as a mental disorder in the International Statistical Classification of Diseases and Related Health Problems (ICD). The World Professional Association for Transgender Health (WPATH) and many transsexual people had recommended this removal,^{[66][67]: 743} arguing that at least some mental health professionals are being insensitive by labelling transsexualism as a "disease" rather than as an inborn trait, as many transsexuals believe it to be.^[68] Now, instead, it is classified as a sexual health condition; this classification continues to enable healthcare systems to provide healthcare needs related to gender.^{[10][failed verification]} The eleventh edition was released in June 2018. The previous version, ICD-10, had incorporated transsexualism, dual role transvestism, and gender identity disorder of childhood into its gender identity disorder category. It defined transsexualism as "[a] desire to live and be accepted as a member of the opposite sex, usually accompanied by a sense of discomfort with, or inappropriateness of, one's anatomic sex, and a wish to have surgery and hormonal treatment to make one's body as congruent as possible with one's preferred sex." ICD-11 renamed Transexualism as Gender incongruence of adolescence or adulthood (HA60), and Gender identity disorder of childhood was renamed Gender incongruence of childhood (HA61).

HA60 of the ICD-11 reads:^[8]

Gender Incongruence of Adolescence and Adulthood is characterised by a marked and persistent incongruence between an individual's experienced gender and the assigned sex, which often leads to a desire to 'transition', in order to live and be accepted as a person of the experienced gender, through hormonal treatment, surgery or other health care services to make the individual's body align, as much as desired and to the extent possible, with the experienced gender. The diagnosis cannot be assigned prior the onset of puberty. [HA61 applies before puberty] Gender variant behaviour and preferences alone are not a basis for assigning the diagnosis.

^{[failed verification]} Historically, transsexualism has also been included in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM). With the DSM-5, transsexualism was removed as a diagnosis, and a diagnosis of gender dysphoria was created in its place.^[69] This change was made to reflect the consensus view by members of the APA that the desire for gender affirming surgery is not, in and of itself, a disorder and that transsexual people should not be stigmatized unnecessarily.^{[9][failed verification]} By including a diagnosis for gender dysphoria, transsexual people are still able to access medical care through the process of transition.

The current diagnosis for transsexual people who present themselves for medical treatment is gender dysphoria (leaving out those who have sexual identity disorders without gender concerns).^[69] According to the Standards of care formulated by WPATH, formerly the Harry Benjamin International Gender Dysphoria Association, this diagnostic label is often necessary to obtain sex reassignment therapy with health insurance coverage, and the designation of gender identity disorders as mental disorders is not a license for stigmatization or for the deprivation of gender patients' civil rights.^[11][70]

Causes, studies, and theories

Causes

This section is transcluded from Causes of gender incongruence. (edit | history)

Studies conducted on twins suggest that there are likely genetic causes of gender incongruence, although the precise genes involved are not known or fully understood.^[71][72]

Biological factors

Genetics

A 2008 study compared the genes of 112 trans women who were mostly already undergoing hormone treatment, with 258 cisgender male controls. Trans women were more likely than cisgender males to have a longer version of a receptor gene (longer repetitions of the gene) for the sex hormone androgen, which reduced its effectiveness at binding testosterone.^[73] The androgen receptor (NR3C4) is activated by the binding of testosterone or dihydrotestosterone, where it plays a critical role in the forming of primary and secondary male sex characteristics. The research weakly suggests reduced androgen and androgen signaling contributes to trans women's identity. The authors say that a decrease in testosterone levels in the brain during development might prevent complete masculinization of trans women's brains, thereby causing a more feminized brain and a female gender identity.^[73][74]

A variant genotype for the CYP17 gene, which acts on the sex hormones pregnenolone and progesterone, has been found to be linked to transsexuality in trans men but not in trans women. Most notably, transmasculine subjects not only had the variant genotype more frequently, but had an allele distribution equivalent to cisgender male controls, unlike the cisgender female controls. The paper concluded that the loss of a female-specific CYP17 T -34C allele distribution pattern is associated with transmasculinity.^[75]

Gender incongruence among twins

In 2013, a twin study combined a survey of pairs of twins where one or both had undergone, or had plans and medical approval to undergo, gender transition, with a literature review of published reports of transgender twins. The study found that one third of identical twin pairs in the sample were both transgender: 13 of 39 (33%) monozygotic or identical pairs of assigned males and 8 of 35 (22.8%) pairs of assigned females. Among dizygotic or genetically non-identical twin pairs, there was only 1 of 38 (2.6%) pairs where both twins were trans.^[76] The significant percentage of identical twin pairs in which both twins are trans and the virtual absence of dizygotic twins (raised in the same family at the same time) in which both were trans would provide evidence that transgender identity is significantly influenced by genetics if both sets were raised in different families.^[76]

Brain structure

General

Transgender brain studies, especially those on trans women attracted to women (gynephilic), and those on trans men attracted to men (androphilic), are limited, as they include only a small number of tested individuals.^[77] Several studies have found a correlation between gender identity and brain structure.^[78][79] A first-of-its-kind study by Zhou et al. (1995) found that in the bed nucleus of the stria terminalis (BSTc), a region of the brain known for sex and anxiety responses (and which is affected by prenatal androgens),^[80] cadavers of six trans women had female-normal BSTc size, similar to the study's cadavers of cisgender women. While the trans women had undergone hormone therapy, and all but one had undergone sex reassignment surgery, this was accounted for by including cadavers of non-trans female and male controls who, for a variety of medical reasons, had experienced hormone reversal. The controls still had sizes typical for their sex. No relationship to sexual orientation was found.^[81]

In a follow-up study, Kruijver et al. (2000) looked at the number of neurons in BSTc instead of volumes. They found the same results as Zhou et al. (1995), but with even more dramatic differences. One transfeminine subject who had never received hormone therapy was also included, and nonetheless matched up with the female neuron counts.^[82]

In 2002, a follow-up study by Chung et al. found that significant sexual dimorphism in BSTc did not establish until adulthood. Chung et al. theorized that changes in fetal hormone levels produce changes in BSTc synaptic density, neuronal activity, or neurochemical content which later lead to size and neuron count changes in BSTc, or alternatively, that the size of BSTc is affected by the generation of a gender identity inconsistent with one's assigned sex.^[83]

It has been suggested that the BSTc differences may be a result of hormone replacement therapy. It has also been suggested that because pedophilic offenders have also been found to have a reduced BSTc, a feminine BSTc may be a marker for paraphilias rather than transgender identity.^[77]

In a review of the evidence in 2006, Gooren considered the earlier research as supporting the concept of gender incongruence as a sexual differentiation disorder of the sexually dimorphic brain.^[84] Dick Swaab (2004) concurred.^[85]

In 2008, Garcia-Falgueras & Swaab discovered that the interstitial nucleus of the anterior hypothalamus (INAH-3), part of the hypothalamic uncinate nucleus, had properties similar to the BSTc with respect to sexual dimorphism and gender incongruence. The same method of controlling for hormone usage was used as in Zhou et al. (1995) and Kruijver et al. (2000). The differences were even more pronounced than with BSTc; control males averaged 1.9 times the volume and 2.3 times the neurons as control females, yet regardless of hormone exposure, trans women were within the female range and the trans men within the male range.^[86]

A 2009 MRI study by Luders et al. found that among 24 trans women not treated with hormone therapy, regional gray matter concentrations were more similar to those of cisgender men than of cisgender women, but there was a significantly greater volume of gray matter in the right putamen compared to cisgender men. Like earlier studies, researchers concluded that transgender identity was associated with a distinct cerebral pattern.^[87] MRI scanning allows easier study of larger brain structures, but independent nuclei are not visible due to lack of contrast between different neurological tissue types, hence other studies on e.g. BSTc were done by dissecting brains post-mortem.

Rametti et al. (2011) studied 18 trans men who had not undergone hormone therapy using diffusion tensor imaging (DTI), an MRI technique which allows visualizing white matter, the structure of which is sexually dimorphic. Rametti et al. discovered that the trans men's white matter, compared to 19 cisgender gynephilic females, showed higher fractional anisotropy values in posterior part of the right SLF, the forceps minor and corticospinal tract". Compared to 24 cisgender males, they showed only lower FA values in the corticospinal tract. The white matter patterns in trans men were found to be shifted in the direction of non-trans males.^[88]

Hulshoff Pol et al. (2006) studied gross brain volume in 8 trans men and in 6 trans women undergoing hormone therapy. They found that hormones altered the sizes of the hypothalamus in a gender-consistent manner: treatment with masculinizing hormones shifted the hypothalamus towards the male direction in the same way as in male controls, and treatment with feminizing hormones shifted the hypothalamus towards the female direction in the same way as female controls. They concluded: "The findings suggest that, throughout life, gonadal hormones remain essential for maintaining aspects of sex-specific differences in the human brain."^[89]

A 2011 review published in Frontiers in Neuroendocrinology found that "Female INAH3 and BSTc have been found in MtF transsexual persons. The only female-to-male (FtM) transsexual person available to us for study so far had a BSTc and INAH3 with clear male characteristics. (...) These sex reversals were found not to be influenced by circulating hormone levels in adulthood, and seem thus to have arisen during development" and that "All observations that support the neurobiological theory about the origin of transsexuality, i.e. that it is the sizes, the neuron numbers, and the functions and connectivity of brain structures, not the sex of their sexual organs, birth certificates or passports, that match their gender identities".^[90]

A 2015 review reported that two studies found a pattern of white matter microstructure differences away from a transgender person's birth sex, and toward their desired sex. In one of these studies, sexual orientation had no effect on the diffusivity measured.^[91]

A 2016 review agreed with the other reviews^[which?] when considering androphilic trans women and gynephilic trans men. It reported that hormone treatment may have large effects on the brain, and that cortical thickness, which is generally thicker in cisgender women's brains than in cisgender men's brains, may also be thicker in trans women's brains, but is present in a different location to cisgender women's brains.^[77] It also stated that for both trans women and trans men, "cross-sex hormone treatment affects the gross morphology as well as the white matter microstructure of the brain. Changes are to be expected when hormones reach the brain in pharmacological doses. Consequently, one cannot take hormone-treated transsexual brain patterns as evidence of the transsexual brain phenotype because the treatment alters brain morphology and obscures the pre-treatment brain pattern."^[77]

A 2019 review in Neuropsychopharmacology found that among transgender individuals meeting diagnostic criteria for gender dysphoria, "cortical thickness, gray matter volume, white matter microstructure, structural connectivity, and corpus callosum shape have been found to be more similar to cisgender control subjects of the same preferred gender compared with those of the same natal sex."^[92]

A 2020 paper^[93] tried to investigate and differentiate between the two competing hypotheses of a neurodevelopmental cortical hypothesis that suggests the existence of different brain phenotypes vs a functional-based hypothesis in relation to regions involved in the own body perception.^[93] Trans men, trans women, and cisgender women all had decreased connectivity compared with cisgender men in superior parietal regions, as part of the salience (SN) and the executive control (ECN) networks.^[93] Trans men also had weaker connectivity compared with cisgender men between intra-SN regions and weaker inter-network connectivity between regions of the SN, the default mode network (DMN), the ECN and the sensorimotor network.^[93] Trans women had lower small-worldness, modularity and clustering coefficient than cisgender men.^[93]

A 2021 review of brain studies published in the Archives of Sexual Behavior found that "although the majority of neuroanatomical, neurophysiological, and neurometabolic features" in transgender people "resemble those of their natal sex rather than those of their experienced gender", for trans women they found feminine and demasculinized traits, and vice versa for trans men. They stated that due to limitations and conflicting results in the studies that had been done, they could not draw general conclusions or identify-specific features that consistently differed between cisgender and transgender people. The review also found differences when comparing cisgender homosexual and heterosexual people, with the same limitations applying.^[94]

Androphilic vs. gynephilic trans women

A 2016 review reported that early-onset androphilic transgender women have a brain structure similar to cisgender women's and unlike cisgender men's, but that they have their own brain phenotype.^[77] It also reported that gynephilic trans women differ from both cisgender female and male controls in non-dimorphic brain areas.^[77] The available research indicates that the brain structure of androphilic trans women with early-onset gender dysphoria is closer to that of cisgender women than that of cisgender men.^[77] It also reports that gynephilic trans women differ from both cisgender female and male controls in non-dimorphic brain areas.^[77] Cortical thickness, which is generally thicker in cisgender women's brains than in cisgender men's brains, may also be thicker in trans women's brains, but is present in a different location to cisgender women's brains.^[77] For trans men, research indicates that those with early-onset gender dysphoria and who are gynephilic have brains that generally correspond to their assigned sex, but that they have their own phenotype with respect to cortical thickness, subcortical structures, and white matter microstructure, especially in the right hemisphere.^[77] Hormone therapy can also affect transgender people's brain structure; it can cause transgender women's brains to become closer to those of cisgender women, and morphological changes observed in the brains of trans men might be due to the anabolic effects of testosterone.^[77]

While MRI taken on gynephilic trans women have likewise shown differences in the brain from non-trans people, no feminization of the brain's structure has been identified.^[77] Neuroscientists Ivanka Savic and Stefan Arver at the Karolinska Institute used MRI to compare 24 gynephilic trans women with 24 cisgender female and 24 cisgender male controls. None of the study participants were undergoing hormone therapy. The researchers found sex-typical differentiation between the trans women and cisgender females, and the cisgender males; but the gynephilic trans women "displayed also singular features and differed from both control groups by having reduced thalamus and putamen volumes and elevated GM volumes in the right insular and inferior frontal cortex and an area covering the right angular gyrus".^[95]

The researchers concluded that:

Contrary to the primary hypothesis, no sex-atypical features with signs of 'feminization' were detected in the transsexual group ... The present study does not support the dogma that [male-to-female transsexuals] have atypical sex dimorphism in the brain but confirms the previously reported sex differences. The observed differences between MtF-TR and controls raise the question as to whether gender dysphoria may be associated with changes in multiple structures and involve a network (rather than a single nodal area).

Berglund et al. (2008) tested the response of gynephilic trans women to two steroids hypothesized to be sex pheromones: the progestin-like 4,16-androstadien-3-one (AND) and the estrogen-like 1,3,5(10),16-tetraen-3-ol (EST). Despite the difference in sexual orientation, the trans women's hypothalamic networks activated in response to the AND pheromone, like the androphilic cis female control groups. Both groups experienced amygdala activation in response to EST. Gynephilic cis male control groups experienced hypothalamic activation in response to EST. However, the trans women also experienced limited hypothalamic activation to EST. The researchers concluded that in terms of pheromone activation, trans women occupy an intermediate position with predominantly female features.^[96] The transfeminine subjects had not undergone any hormonal treatment at the time of the study, according to their own declaration beforehand, and confirmed by repeated tests of hormonal levels.^[96]

Gynephilic trans men

Fewer brain structure studies have been performed on transgender men than on transgender women.^[77] A team of neuroscientists, led by Nawata in Japan, used a technique called single-photon emission computed tomography (SPECT) to compare the regional cerebral blood flow (rCBF) of 11 gynephilic trans men with that of 9 androphilic cis females. Although the study did not include a sample of cisgender males so that a conclusion of "male shift" could be made, the study did reveal that the gynephilic trans men showed significant decrease in blood flow in the left anterior cingulate cortex and a significant increase in the right insula, two brain regions known to respond during sexual arousal.^[97]

A 2016 review reported that the brain structure of early-onset gynephilic trans men generally corresponds to their assigned sex, but that they have their own phenotype with respect to cortical thickness, subcortical structures, and white matter microstructure, especially in the right hemisphere.^[77] Morphological increments observed in the brains of trans men might be due to the anabolic effects of testosterone.^[77]

Prenatal androgen exposure

Prenatal androgen exposure, the lack thereof, or low sensitivity to prenatal androgens are commonly cited as mechanisms to explain the above discoveries. To test this, studies have examined the differences between trans and cisgender individuals in digit ratio (a generally accepted marker for prenatal androgen exposure). A meta-analysis concluded that the effect sizes for this association were small or nonexistent.^[98]

In people with XX chromosomes, congenital adrenal hyperplasia (CAH) results in heightened exposure to prenatal androgens, resulting in masculinization of the genitalia. Individuals with CAH are typically subjected to medical interventions including prenatal hormone treatment^[99] and postnatal genital reconstructive surgeries.^[100] Such treatments are sometimes criticized by intersex rights organizations as non-consensual, invasive, and unnecessary interventions. Individuals with CAH are usually assigned female and tend to develop similar cognitive abilities to the typical females, including spatial ability, verbal ability, language lateralization, handedness and aggression. Research has shown that people with CAH and XX chromosomes will be more likely to experience same-sex attraction,^[99] and at least 5.2% of these individuals develop serious gender dysphoria.^[101]

In males with 5-alpha-reductase deficiency, conversion of testosterone to dihydrotestosterone is disrupted, decreasing the masculinization of genitalia. Individuals with this condition are typically assigned female and raised as girls due to their feminine appearance at a young age. However, more than half of males with this condition raised as females come to identify as male later in life. Scientists speculate that the definition of masculine characteristics during puberty and the increased social status afforded to men are two possible motivations for a female-to-male transition.^[101]

Onset

According to the DSM-5, gender dysphoria in those assigned male at birth tends to follow one of two broad trajectories: early-onset or late-onset. Early-onset gender dysphoria is behaviorally visible in childhood. Sometimes gender dysphoria will stop for a while in this group, and they will identify as gay or homosexual for a period of time, followed by recurrence of gender dysphoria. This group is usually androphilic in adulthood. Late-onset gender dysphoria does not include visible signs in early childhood, but some report having had wishes to be the opposite sex in childhood that they did not report to others. Trans women who experience late-onset gender dysphoria are more likely be attracted to women and may identify as lesbians or bisexual. It is common for people assigned male at birth who have late-onset gender dysphoria to experience sexual excitement from cross-dressing. In those assigned female at birth, early-onset gender dysphoria is the most common course. This group is usually sexually attracted to women. Trans men who experience late-onset gender dysphoria will usually be sexually attracted to men and may identify as gay.^[102]

Blanchard's typology

Further information: Blanchard's transsexualism typology

In the 1980s and 1990s, sexologist Ray Blanchard developed a taxonomy of male-to-female transsexualism^[103] built upon the work of his colleague Kurt Freund,^[104] which argues that trans women have one of two primary causes of gender dysphoria.^{[105][106][107]} Blanchard theorized that "homosexual transsexuals" (a taxonomic category referring to trans women attracted to men) are attracted to men and develop gender dysphoria typically during childhood, and characterizes them as displaying overt and obvious femininity since childhood; he characterizes "non-homosexual transsexuals" (trans women who are sexually attracted to women) as developing gender dysphoria primarily due to autogynephilia (sexual arousal by the thought or image of themselves as a woman^[103]), and as attracted to women, attracted to both women and men (Blanchard calls this "pseudo-bisexuality", believing attraction to males to be not genuine, but part of the performance of an autogynephilic sexual fantasy), or asexual.

Blanchard's theory has received support from J. Michael Bailey, Anne Lawrence, and James Cantor. Blanchard argued that there are significant differences between the two groups, including sexuality, age of transition, ethnicity, IQ, fetishism, and quality of adjustment.^{[108][109][103][110]} However, the theory has been criticized in papers from Veale, Nuttbrock, Moser, and others who argue that it is poorly representative of trans women and non-instructive, and that the experiments behind it are poorly controlled and/or contradicted by other data.^{[111][112][113]} A 2009 study by Charles Moser of 29 cisgender women in the healthcare field based on Blanchard's methods for identifying autogynephilia found that 93% of respondents qualified as autogynephiles based on their own responses.^[114]

See also

• Genetic diagnosis of intersex
• Feminine essence concept of transsexuality
• Intersex and LGBT
• Sexual identity

References

1. Darmanin, Jules (12 July 2017). "Les retrouvailles très émouvantes entre Chelsea Manning et une femme qui l'a inspirée". Buzzfeed News (in French). Retrieved 27 November 2020. Dans un entretien par téléphone avec BuzzFeed News, elle développe: «Ça se passait dans un contexte particulier, juste après une chirurgie de réassignation que j'ai été faire en Thaïlande. Il se trouve que j'avais déjà été interviewée par des médias, et que j'avais une image qui passait plutôt bien.» À travers les lettres XY marquées sur sa main, July voulait «clairement expliciter [sa] situation en tant que transsexuelle.
2. Bevan, Thomas E. (2015). The psychobiology of transsexualism and transgenderism : a new view based on scientific evidence. Santa Barbara, California. p. 42. ISBN 978-1-4408-3126-3. OCLC 881721443. The term transsexual was introduced by Cauldwell (1949) and popularized by Harry Benjamin (1966) ... . The term transgender was coined by John Oliven (1965) and popularized by various transgender people who pioneered the concept and practice of transgenderism. It is sometimes said that Virginia Prince (1976) popularized the term, but history shows that many transgender people advocated the use of this term much more than Prince. The adjective transgendered should not be used ... . Transsexuals constitute a subset of transgender people.{{cite book}}: CS1 maint: location missing publisher (link)
3. Alegria, Christine Aramburu (22 March 2011). "Transgender identity and health care: Implications for psychosocial and physical evaluation". Journal of the American Academy of Nurse Practitioners. Wiley. 23 (4): 175–182. doi:10.1111/j.1745-7599.2010.00595.x. ISSN 1041-2972. PMID 21489011. S2CID 205909330. Transgender, Umbrella term for persons who do not conform to gender norms in their identity and/or behavior (Meyerowitz, 2002). Transsexual, Subset of transgenderism; persons who feel discordance between natal sex and identity (Meyerowitz, 2002).
4. Stryker, Susan; Whittle, Stephen (2006). The Transgender Studies Reader. New York: Routledge. pp. 1–17. ISBN 0-415-94708-1. OCLC 62782200.
5. Winters, Kelley; Karasic, Dan (2008). Gender Madness in American Psychiatry: Essays From the Struggle for Dignity. Dillon, CO: GID Reform Advocates. p. 198. ISBN 978-1-4392-2388-8. OCLC 367582287. Some Transsexual individuals also identify with the broader transgender community; others do not.
6. . Gender Centre. March 2014. Archived from the original on 4 March 2016. Retrieved 5 July 2016. Transsexualism is often included within the broader term 'transgender', which is generally considered an umbrella term for people who do not conform to typically accepted gender roles for the sex they were assigned at birth. The term 'transgender' is a word employed by activists to encompass as many groups of gender diverse people as possible. However, many of these groups individually don't identify with the term. Many health clinics and services set up to serve gender variant communities employ the term, however most of the people using these services again don't identify with this term. The rejection of this political category by those that it is designed to cover clearly illustrates the difference between self-identification and categories that are imposed by observers to understand other people.
7. Valentine, David (30 August 2007). Imagining Transgender. Duke University Press. doi:10.2307/j.ctv125jv36. ISBN 978-0-8223-9021-3.
8. "ICD-11 for Mortality and Morbidity Statistics". icd.who.int. Retrieved 27 October 2022.
9. (PDF). American Psychiatric Publishing. 2013. Archived from the original (PDF) on 11 June 2013. Retrieved 4 July 2021.
10. Kacala, Alexander (18 June 2018). . Hornet. Archived from the original on 19 June 2018. Retrieved 19 June 2018.
11. "World Professional Association for Transgender Health". WPATH. 25 September 2011. from the original on 22 August 2011. Retrieved 23 February 2012.
12. "Gatekeeping". TransHub. Retrieved 27 October 2022.
13. Encyclopedia of Sex and Sexuality: Understanding Biology, Psychology, and Culture. Heather L. Armstrong. Santa Barbara, California: Greenwood Publishing Group. 2021. ISBN 978-1-61069-875-7. OCLC 1161996063.{{cite book}}: CS1 maint: others (link)
14. Haire, Norman (1934). . Archived from the original on 20 November 2007 – via Transgenderzone.com.
15. Hirschfeld, Magnus; "Die intersexuelle Konstitution" in Jahrbuch für sexuelle Zwischenstufen 1923.
16. Cauldwell, David Oliver (1949). . Sexology: Sex Science Magazine. 16. Archived from the original on 30 September 2011.. See also the neo-Latin term "psychopathia transexualis".
17. Cauldwell, David O. (1950). . Big blue book. Haldeman-Julius Publications. Archived from the original on 19 June 2010.
18. Meyerowitz, Joanne J. (2002). How sex changed : a history of transsexuality in the United States. Cambridge, Mass.: Harvard University Press. pp. 43–44. ISBN 978-0-6740-1379-7.
19. Benjamin, H. (1969). "Introduction". In Green, R.; Money, J. (eds.). Transsexualism and Sex Reassignment. Baltimore: Johns Hopkins.
20. Benjamin 1966, p. 23
21. Schaefer, L.C.; Wheeler, C.C (1983). The non-surgical true Transsexual: a theoretical rationale. Harry Benjamin International Gender Dysphoria Association VIII International Symposium. Bordeaux, France.
22. Gaughan, Sharon (19 August 2006). "What About Non-op Transsexuals? A No-op Notion". TS-SI. from the original on 20 December 2008. Retrieved 30 September 2008.
23. Frye, Phyllis Randolph; Currah, Paisley; Juang, Richard M.; Minter, Shannon (2006). Transgender rights. Minneapolis. ISBN 0-8166-4311-3. OCLC 68221085.{{cite book}}: CS1 maint: location missing publisher (link)
24. Polly, Ryan; Nicole, Julie (2011). "Understanding the Transsexual Patient". Advanced Emergency Nursing Journal. Ovid Technologies (Wolters Kluwer Health). 33 (1): 55–64. doi:10.1097/tme.0b013e3182080ef4. ISSN 1931-4485. PMID 21317698. S2CID 2481961. The use of terminology by transsexual individuals to self-identify varies. As aforementioned, many transsexual individuals prefer the term transgender, or simply trans, as it is more inclusive and carries fewer stigmas. There are some transsexual individuals[,] however, who reject the term transgender; these individuals view transsexualism as a treatable congenital condition. Following medical and/or surgical transition, they live within the binary as either a man or a woman and may not disclose their transition history.
25. Swenson, A (2014). "Medical Care of the Transgender Patient". Family Medicine. While some transsexual people still prefer to use the term to describe themselves, many transgender people prefer the term transgender to transsexual.
26. . GLAAD Media Reference Guide. n.d. Archived from the original on 23 February 2022.
27. McGuinness, S; Alghrani, A (2008). "Gender and parenthood: the case for realignment". Medical Law Review. 16 (2): 261–83. doi:10.1093/medlaw/fwn010. hdl:1983/a58f6bfe-0d1a-45e5-99f8-b0c0ee37eaab. PMID 18441087.
28. Whittle, S (2002). Respect and Equality: Transsexual and Transgender Rights. London: Cavendish. p. 7. ISBN 9781859417430.
29. Harris, Alex (2012). "Non-binary Gender Concepts and the Evolving Legal Treatment of UK Transsexed Individuals: A Practical Consideration of the Possibilities of Butler". Journal of International Women's Studies. 13 (6): 57–71. from the original on 20 September 2015. Retrieved 8 September 2015.
30. Denny, Dallas (2006). "Chapter 9: Transgender Communities of the United States in the Late Twentieth Century". In Currah, Paisley (ed.). Transgender Rights.
31. (PDF). Boston, Mass.: Fenway Health. January 2010. p. 15. Archived from the original (PDF) on 19 October 2013.
32. Parker, Jerry (18 October 1979). "Christine Recalls Life as Boy from the Bronx". Newsday/Winnipeg Free Press. from the original on 25 April 2012. Retrieved 28 May 2012. If you understand trans-genders," she says, (the word she prefers to transsexuals), "then you understand that gender doesn't have to do with bed partners, it has to do with identity.
33. "News From California: 'Transgender'". Appeal-Democrat/Associate Press. 11 May 1982. pp. A–10. from the original on 12 April 2012. Retrieved 28 May 2012. she describes people who have had such operations' "transgender" rather than transsexual. "Sexuality is who you sleep with, but gender is who you are," she explained
34. Transgender identities: Towards a social analysis of gender diversity. Sally Hines, Tam Sanger. New York: Routledge. March 2010. p. 43. ISBN 978-0-415-99930-4. OCLC 1076752703.{{cite book}}: CS1 maint: others (link)
35. "GLAAD Media Reference Guide - Transgender Terms". GLAAD. 22 February 2022. Retrieved 30 April 2022.
36. "transsexual, adj. and n.". Oxford English Dictionary (3rd ed.). Oxford University Press. March 2018. (Subscription or participating institution membership required.)
37. Harris, Alex. "Non-binary Gender Concepts and the Evolving Legal Treatment of UK Transsexed Individuals: A Practical Consideration of the Possibilities of Butler". Journal of International Women's Studies. 13 (6). from the original on 25 February 2014. Retrieved 4 July 2021.
38. Currah, Paisley; Juang, Richard M.; Minter, Shannon Price (18 August 2006). Transgender Rights. U of Minnesota Press. ISBN 978-1-4529-4258-2.
39. Pauly, Ira B. (28 May 1993). "Terminology and Classification of Gender Identity Disorders". Journal of Psychology & Human Sexuality. 5 (4): 1–12. doi:10.1300/J056v05n04_01. ISSN 0890-7064. S2CID 142954603. Archived from the original on 11 January 2013. Retrieved 26 February 2007.
40. Laub, D. R .; N. Fisk (April 1974). "A rehabilitation program for gender dysphoria syndrome by surgical sex change". Plastic and Reconstructive Surgery. 53 (4): 388–403. doi:10.1097/00006534-197404000-00003. PMID 4592953. S2CID 42739374.
41. Fisk, N. (1974). Laub, D.; Gandy P. (eds.). "Gender Dysphoria Syndrome". Proceedings of the Second Interdisciplinary Symposium on Gender Dysphoria Syndrome: 7–14.
42. Aggrawal, Anil (2008). Forensic and Medico-legal Aspects of Sexual Crimes and Unusual Sexual Practices.
43. Ekins, Richard; King, Dave (2006). The Transgender Phenomenon. London: SAGE. ISBN 978-0-7619-7164-1.
44. Labonté, Richard; Schimel, Lawrence (2009). Second Person Queer: Who You are (so Far). Arsenal Pulp Press. ISBN 978-1-55152-245-6.
45. Bornstein, Kate; Bergman, S. Bear (2010). Gender Outlaws: The Next Generation. Basic Books. ISBN 9781580053082. OCLC 526069032.
46. Blanchard, Ray (1989). "The classification and labeling of nonhomosexual gender dysphorias". Archives of Sexual Behavior. Springer Science and Business Media LLC. 18 (4): 315–334. doi:10.1007/bf01541951. ISSN 0004-0002. PMID 2673136. S2CID 43151898.
47. Bagemihl, Bruce (1997). "Surrogate Phonology and Transsexual Faggotry: A linguistic analogy for uncoupling sexual orientation from gender identity". In Livia, Anna; Hall, Kira (eds.). Queerly Phrased: Language, Gender, and Sexuality. New York: Oxford University Press. p. 380. ISBN 978-0-19-535577-2. OCLC 252561680.
48. Wahng SJ (2004). Double Cross: Transmasculinity Asian American Gendering in Trappings of Transhood. in Aldama AJ (ed.) Violence and the Body: Race, Gender, and the State. Indiana University Press. ISBN 0-253-34171-X
49. Leiblum, Sandra Risa; Rosen, Raymond (2000). Principles and practice of sex therapy (3rd ed.). New York: Guilford Press. ISBN 1-57230-574-6. OCLC 43845675.
50. Bancroft, John (2008). "Lust or Identity?". Archives of Sexual Behavior. 37 (3): 426–428. doi:10.1007/s10508-008-9317-1. PMID 18431640. S2CID 33178427.
51. Moser, Charles (July 2010). "Blanchard's Autogynephilia Theory: A Critique". Journal of Homosexuality (6 ed.). 57 (6): 790–809. doi:10.1080/00918369.2010.486241. PMID 20582803. S2CID 8765340.
52. Jordan-Young, Rebecca M. (2010). Brain storm : the flaws in the science of sex differences. Cambridge, Mass.: Harvard University Press. ISBN 978-0-674-05879-8. OCLC 680017826.
53. Langevin, Ron (1983). Sexual strands : understanding and treating sexual anomalies in men. Hillsdale, N.J.: L. Erlbaum Associates. ISBN 0-89859-205-4. OCLC 8113505.
54. "Sexual and Gender Identity Disorders". (4th ed.). American Psychiatric Association. 1994. p. 534. ISBN 0-89042-061-0. OCLC 29953039. Archived from the original on 11 February 2007. Retrieved 12 June 2022. For sexually mature individuals, the following specifiers may be noted based on the individual's sexual orientation: Sexually Attracted to Males, Sexually Attracted to Females, Sexually Attracted to Both, and Sexually Attracted to Neither
55. Girshick, Lori B. (15 September 2009). Transgender Voices: Beyond Women and Men. Hanover: University Press of New England. p. 16. ISBN 978-1-58465-838-2. OCLC 929272452. from the original on 16 March 2017. Retrieved 15 March 2017.
56. Partridge, Eric (2006). The New Partridge Dictionary of Slang and Unconventional English: J-Z. Taylor & Francis. p. 1540. ISBN 978-0-415-25938-5. OCLC 180087865. from the original on 16 March 2017. Retrieved 15 March 2017.
57. Cite error: The named reference :02whip was invoked but never defined (see the help page).
58. "The Trans History You Weren't Taught in Schools". YES! Magazine. from the original on 23 January 2022. Retrieved 23 January 2022.
59. Janssen, Diederik F. (21 April 2020). "Transgenderism Before Gender: Nosology from the Sixteenth Through Mid-Twentieth Century". Archives of Sexual Behavior. 49 (5): 1415–1425. doi:10.1007/s10508-020-01715-w. ISSN 0004-0002. PMID 32319033. S2CID 216073926.
60. Hickman, H.; Porfilio, B.J. (2012). The New Politics of the Textbook: Problematizing the Portrayal of Marginalized Groups in Textbooks. Constructing Knowledge: Curriculum Studies in Action. SensePublishers. p. 235. ISBN 978-94-6091-912-1. from the original on 10 January 2023. Retrieved 10 January 2023.
61. Janssen, Diederik F. (21 April 2020). "Transgenderism Before Gender: Nosology from the Sixteenth Through Mid-Twentieth Century". Archives of Sexual Behavior. 49 (5): 1415–1425. doi:10.1007/s10508-020-01715-w. ISSN 0004-0002. PMID 32319033. S2CID 216073926.
62. "Holocaust Memorial Day Trust | 6 May 1933: Looting of the Institute of Sexology". from the original on 7 March 2022. Retrieved 20 March 2022.
63. "Queer Science: The Use and Abuse of Research into Homosexuality". The Washington Post. from the original on 13 December 2017. Retrieved 17 November 2022.
64. Smith, Shannon; Han, Justin (1 April 2019). "The trans-formation of gender confirming surgery: a brief history". The Journal of Urology. 201 (4S): e244. doi:10.1097/01.JU.0000555394.71572.8e. S2CID 149966616.
65. Goldberg, Abbie E.; Beemyn, Genny, eds. (2021). "Ancient and Medieval Times". The SAGE Encyclopedia of Trans Studies. SAGE Publishing. p. 32. doi:10.4135/9781544393858.n188. ISBN 9781544393810. S2CID 242422061.
66. (PDF). WPATH. 31 May 2013. Archived from the original (PDF) on 14 August 2015. Retrieved 21 March 2015.
67. Encyclopedia of sex and sexuality : understanding biology, psychology, and culture. Heather L. Armstrong. Santa Barbara, California. 2021. ISBN 978-1-61069-875-7. OCLC 1161996063.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
68. Green, Jamison (May 2004). Becoming a Visible Man. Vanderbilt University Press. p. 79. ISBN 978-0-8265-1457-8.
69. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. American Psychiatric Publishing. ISBN 978-0-89042-554-1.
70. (PDF). Archived from the original (PDF) on 3 March 2012. Retrieved 23 February 2012.
71. Heylens G, De Cuypere G, Zucker KJ, Schelfaut C, Elaut E, Vanden Bossche H, et al. (March 2012). "Gender identity disorder in twins: a review of the case report literature". The Journal of Sexual Medicine. 9 (3): 751–7. doi:10.1111/j.1743-6109.2011.02567.x. PMID 22146048. Of 23 monozygotic female and male twins, nine (39.1%) were concordant for GID; in contrast, none of the 21 same‐sex dizygotic female and male twins were concordant for GID, a statistically significant difference (P = 0.005)... These findings suggest a role for genetic factors in the development of GID.
72. Diamond M (2013). "Transsexuality Among Twins: Identity Concordance, Transition, Rearing, and Orientation". International Journal of Transgender Health. 14 (1): 24–38. doi:10.1080/15532739.2013.750222. S2CID 144330783. Combining data from the present survey with those from past-published reports, 20% of all male and female monozygotic twin pairs were found concordant for transsexual identity... The responses of our twins relative to their rearing, along with our findings regarding some of their experiences during childhood and adolescence show their identity was much more influenced by their genetics than their rearing.
73. Hare L, Bernard P, Sánchez FJ, Baird PN, Vilain E, Kennedy T, Harley VR (January 2009). "Androgen receptor repeat length polymorphism associated with male-to-female transsexualism". Biological Psychiatry. 65 (1): 93–6. doi:10.1016/j.biopsych.2008.08.033. PMC 3402034. PMID 18962445.
74. "Transsexual study reveals genetic link". abc.net.au. 27 October 2008.
75. Bentz EK, Hefler LA, Kaufmann U, Huber JC, Kolbus A, Tempfer CB (July 2008). "A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism". Fertility and Sterility. 90 (1): 56–9. doi:10.1016/j.fertnstert.2007.05.056. PMID 17765230.
76. Diamond M (2013). "Transsexuality Among Twins: Identity Concordance, Transition, Rearing, and Orientation". International Journal of Transgender Health. 14 (1): 24–38. doi:10.1080/15532739.2013.750222. S2CID 144330783. Combining data from the present survey with those from past-published reports, 20% of all male and female monozygotic twin pairs were found concordant for transsexual identity... The responses of our twins relative to their rearing, along with our findings regarding some of their experiences during childhood and adolescence show their identity was much more influenced by their genetics than their rearing.
77. Guillamon A, Junque C, Gómez-Gil E (October 2016). "A Review of the Status of Brain Structure Research in Transsexualism". Archives of Sexual Behavior. 45 (7): 1615–48. doi:10.1007/s10508-016-0768-5. PMC 4987404. PMID 27255307.
78. Cite error: The named reference :3 was invoked but never defined (see the help page).
79. For a survey, see Swaab DF, Castellanos-Cruz L, Bao AM (2016). "The Human Brain and Gender: Sexual Differentiation of Our Brains.". In Schreiber G (ed.). Transsexuality in Theology and Neuroscience. Findings, Controversies, and Perspectives. Berlin and Boston: Walter de Gruyter. pp. 23–42. ISBN 978-3-11-044080-5.
80. Carlson NR (2010). Psychology: The Science of Behavior (7th ed.). Pearson Education. p. 418.
81. Zhou JN, Hofman MA, Gooren LJ, Swaab DF (November 1995). "A sex difference in the human brain and its relation to transsexuality". Nature. 378 (6552): 68–70. Bibcode:1995Natur.378...68Z. doi:10.1038/378068a0. hdl:20.500.11755/9da6a0a1-f622-44f3-ac4f-fec297a7c6c2. PMID 7477289. S2CID 4344570.
82. Kruijver FP, Zhou JN, Pool CW, Hofman MA, Gooren LJ, Swaab DF (May 2000). "Male-to-female transsexuals have female neuron numbers in a limbic nucleus". The Journal of Clinical Endocrinology and Metabolism. 85 (5): 2034–41. doi:10.1210/jcem.85.5.6564. PMID 10843193.
83. Chung WC, De Vries GJ, Swaab DF (February 2002). "Sexual differentiation of the bed nucleus of the stria terminalis in humans may extend into adulthood". The Journal of Neuroscience. 22 (3): 1027–33. doi:10.1523/jneurosci.22-03-01027.2002. PMC 6758506. PMID 11826131.
84. Gooren L (November 2006). "The biology of human psychosexual differentiation". Hormones and Behavior. 50 (4): 589–601. doi:10.1016/j.yhbeh.2006.06.011. PMID 16870186. S2CID 21060826.
85. Swaab DF (December 2004). "Sexual differentiation of the human brain: relevance for gender identity, transsexualism and sexual orientation". Gynecological Endocrinology. 19 (6): 301–12. doi:10.1080/09513590400018231. PMID 15724806. S2CID 1410435.
86. Garcia-Falgueras A, Swaab DF (December 2008). "A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity". Brain. 131 (Pt 12): 3132–46. doi:10.1093/brain/awn276. PMID 18980961.
87. Luders E, Sánchez FJ, Gaser C, Toga AW, Narr KL, Hamilton LS, Vilain E (July 2009). "Regional gray matter variation in male-to-female transsexualism". NeuroImage. 46 (4): 904–7. doi:10.1016/j.neuroimage.2009.03.048. PMC 2754583. PMID 19341803.
88. Rametti G, Carrillo B, Gómez-Gil E, Junque C, Segovia S, Gomez Á, Guillamon A (February 2011). "White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study". Journal of Psychiatric Research. 45 (2): 199–204. doi:10.1016/j.jpsychires.2010.05.006. PMID 20562024.
89. Pol HE, Cohen-Kettenis PT, Van Haren NE, Peper JS, Brans RG, Cahn W, Schnack HG, Gooren LJ, Kahn RS (2006). "Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure". European Journal of Endocrinology. 155: S107–S114. doi:10.1530/eje.1.02248.
90. Bao, Ai-Min; Swaab, Dick (18 February 2011). "Sexual differentiation of the human brain: relation to gender identity, sexual orientation and neuropsychiatric disorders". Frontiers in Neuroendocrinology. 32 (2): 214–226. doi:10.1016/j.yfrne.2011.02.007. PMID 21334362. S2CID 8735185.
91. Smith, Elke Stefanie; Junger, Jessica; Derntl, Birgit; Habel, Ute (1 December 2015). "The transsexual brain – A review of findings on the neural basis of transsexualism". Neuroscience & Biobehavioral Reviews. 59: 251–266. doi:10.1016/j.neubiorev.2015.09.008. ISSN 0149-7634. PMID 26429593. S2CID 23913935. Retrieved 4 October 2021.
92. Nguyen, Hillary B.; Loughead, James; Lipner, Emily; Hantsoo, Liisa; Kornfield, Sara L.; Epperson, C. Neill (January 2019). "What has sex got to do with it? The role of hormones in the transgender brain". Neuropsychopharmacology. 44 (1): 22–37. doi:10.1038/s41386-018-0140-7. ISSN 1740-634X. PMC 6235900. PMID 30082887.
93. Uribe, Carme; Junque, Carme; Gómez-Gil, Esther; Abos, Alexandra; Mueller, Sven C.; Guillamon, Antonio (1 May 2020). "Brain network interactions in transgender individuals with gender incongruence". NeuroImage. 211: 116613. doi:10.1016/j.neuroimage.2020.116613. ISSN 1053-8119. PMID 32057995. S2CID 211068133.
94. Frigerio, Alberto; Ballerini, Lucia; Valdes-Hernandez, Maria (2021). "Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature". Archives of Sexual Behavior. 50 (8): 3329–3352. doi:10.1007/s10508-021-02005-9. hdl:20.500.11820/7258d49f-d222-4094-a40f-dc564d163ea7. PMC 8604863. PMID 33956296. S2CID 233870640. Results suggest that, although the majority of neuroanatomical, neurophysiological, and neurometabolic features in transgenders resemble those of their natal sex rather than those of their experienced gender,...in the gender identity investigation, in MtF it was possible to find traits which are "feminine and demasculinized" and in FtM it was possible to find traits which are "masculine and defeminized" (Kreukels & Guillamon, 2016)....Due to conflicting results, it was, however, not possible to identify specific brain features which consistently differ between cisgender and transgender nor between heterosexual and homosexual groups. Very small brain changes, to date undetectable using the current neuroimaging tools, may affect behavior. The small number of studies, the small sample size of each study, the heterogeneity of investigations, the lack of negative results reported by some studies, and the fact that some studies did not report the sexual orientation of the individuals that composed their sample did not allow drawing general conclusions. Moreover, as the samples of the publications involved are not representative of the population analyzed, caution should be taken in the interpretation of the results of this review.
95. Savic I, Arver S (November 2011). "Sex dimorphism of the brain in male-to-female transsexuals". Cerebral Cortex. 21 (11): 2525–33. doi:10.1093/cercor/bhr032. PMID 21467211.
96. Berglund H, Lindström P, Dhejne-Helmy C, Savic I (August 2008). "Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids". Cerebral Cortex. 18 (8): 1900–8. doi:10.1093/cercor/bhm216. PMID 18056697.
97. Nawata H, Ogomori K, Tanaka M, Nishimura R, Urashima H, Yano R, et al. (April 2010). "Regional cerebral blood flow changes in female to male gender identity disorder". Psychiatry and Clinical Neurosciences. 64 (2): 157–61. doi:10.1111/j.1440-1819.2009.02059.x. PMID 20132527.
98. Voracek M, Kaden A, Kossmeier M, Pietschnig J, Tran US (April 2018). "Meta-Analysis Shows Associations of Digit Ratio (2D:4D) and Transgender Identity Are Small at Best". Endocrine Practice. 24 (4): 386–390. doi:10.4158/EP-2017-0024. PMID 29561190.
99. Dreger A, Feder EK, Tamar-Mattis A (September 2012). "Prenatal Dexamethasone for Congenital Adrenal Hyperplasia: An Ethics Canary in the Modern Medical Mine". Journal of Bioethical Inquiry. 9 (3): 277–294. doi:10.1007/s11673-012-9384-9. PMC 3416978. PMID 22904609.
100. Clayton PE, Miller WL, Oberfield SE, Ritzén EM, Sippell WG, Speiser PW (2002). "Consensus statement on 21-hydroxylase deficiency from the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society". Hormone Research. 58 (4): 188–95. doi:10.1159/000065490. PMID 12324718. S2CID 41346214.
101. Erickson-Schroth L (2013). "Update on the Biology of Transgender Identity". Journal of Gay & Lesbian Mental Health. 17 (2): 150–74. doi:10.1080/19359705.2013.753393. S2CID 216136930.
102. Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2013. pp. 451–460. ISBN 978-0-89042-554-1.
103. Blanchard R (October 1989). "The concept of autogynephilia and the typology of male gender dysphoria". The Journal of Nervous and Mental Disease. 177 (10): 616–23. doi:10.1097/00005053-198910000-00004. PMID 2794988.
104. Freund K, Steiner BW, Chan S (February 1982). "Two types of cross-gender identity". Archives of Sexual Behavior. 11 (1): 49–63. doi:10.1007/BF01541365. PMID 7073469. S2CID 42131695.
105. Bailey JM (2003). The Man Who Would Be Queen: The Science of Gender-Bending and Transsexualism. Washington, D.C.: Joseph Henry Press. p. 170. ISBN 978-0-309-08418-5. OCLC 52779246.
106. Blanchard R (August 2005). "Early history of the concept of autogynephilia". Archives of Sexual Behavior. 34 (4): 439–46. doi:10.1007/s10508-005-4343-8. PMID 16010466. S2CID 15986011.
107. Smith YL, van Goozen SH, Kuiper AJ, Cohen-Kettenis PT (December 2005). "Transsexual subtypes: clinical and theoretical significance". Psychiatry Research. 137 (3): 151–60. doi:10.1016/j.psychres.2005.01.008. PMID 16298429. S2CID 207445960.
108. Blanchard R (August 1989). "The classification and labeling of nonhomosexual gender dysphorias". Archives of Sexual Behavior. 18 (4): 315–34. doi:10.1007/BF01541951. PMID 2673136. S2CID 43151898.
109. Blanchard R (January 1988). "Nonhomosexual gender dysphoria". Journal of Sex Research. 24 (1): 188–93. doi:10.1080/00224498809551410. PMID 22375647.
110. Blanchard R (Winter 1991). "Clinical observations and systematic studies of autogynephilia". Journal of Sex & Marital Therapy. 17 (4): 235–51. doi:10.1080/00926239108404348. PMID 1815090.
111. Veale JF, Clarke DE, Lomax TC (August 2008). "Sexuality of male-to-female transsexuals". Archives of Sexual Behavior. 37 (4): 586–97. doi:10.1007/s10508-007-9306-9. PMID 18299976. S2CID 207089236.
112. Moser C (2010). "Blanchard's Autogynephilia Theory: a critique". Journal of Homosexuality. 57 (6): 790–809. doi:10.1080/00918369.2010.486241. PMID 20582803. S2CID 8765340.
113. Nuttbrock L, Bockting W, Mason M, Hwahng S, Rosenblum A, Macri M, Becker J (April 2011). "A further assessment of Blanchard's typology of homosexual versus non-homosexual or autogynephilic gender dysphoria". Archives of Sexual Behavior. 40 (2): 247–57. doi:10.1007/s10508-009-9579-2. PMC 2894986. PMID 20039113.
114. Moser C (2009). "Autogynephilia in women". Journal of Homosexuality. 56 (5): 539–47. doi:10.1080/00918360903005212. PMID 19591032. S2CID 14368724.

Focus on trans women over trans men

Historically, formal efforts by the medical community to provide transsexual healthcare were extremely focused on transsexual women, with little thought for transsexual men. Julia Serano suggests that effemimania (the idea that male femininity is more psychopathological than female masculinity) was the driving factor. She sees this as a kind of transmisogyny (hatred of trans women as an extension of sexism).^{[1]: 126–127} This effimimania conflates male homosexuality, transsexual women, and feminine gender expression, while treating them all as a disease.^[1]: 129 She points to the medical community's long love of now outdated theories such as autogynephilia.^[1]: 131

Medical assistance

Individuals make different choices regarding sex reassignment therapy, which may include hormones, minor to extensive surgery, social changes, and psychological interventions. The extent of medical intervention is a highly personal decision: there is no one-size-fits-all solution.

Hormone replacement therapy

Main article: Transgender hormone therapy

Transsexual individuals frequently opt for masculinizing or feminizing hormone replacement therapy (HRT) to modify secondary sex characteristics.

Sex reassignment therapy

Main article: Sex reassignment therapy

Sex reassignment therapy (SRT) is an umbrella term for all medical treatments related to sex reassignment of both transgender and intersex people. Sex reassignment surgery (such as orchiectomy) alters primary sex characteristics, including chest surgery such as top surgery or breast augmentation, or, in the case of trans women, a trachea shave, facial feminization surgery or permanent hair removal.

To obtain sex reassignment therapy, transsexual people are generally required to undergo a psychological evaluation and receive a diagnosis of gender identity disorder in accordance with the Standards of Care (SOC) as published by the World Professional Association for Transgender Health.^[2] This assessment is usually accompanied by counseling on issues of adjustment to the desired gender role, effects and risks of medical treatments, and sometimes also by psychological therapy. The SOC are intended as guidelines, not inflexible rules, and are intended to ensure that clients are properly informed and in sound psychological health, and to discourage people from transitioning based on unrealistic expectations.

Gender roles and transitioning

After an initial psychological evaluation, trans men and trans women may begin medical treatment, starting with hormone replacement therapy^[3][4] or hormone blockers. In these cases, people who change their gender are usually required to live as members of their target gender for at least one year prior to genital surgery, gaining real-life experience, which is sometimes called the "real-life test" (RLT).^[3] Transsexual individuals may undergo some, all, or none of the medical procedures available, depending on personal feelings, health, income, and other considerations. Some people posit that transsexualism is a physical condition, not a psychological issue, and assert that sex reassignment therapy should be given on request. (Brown 103)

Like other trans people, transsexual people may refer to themselves as trans men or trans women. Transsexual people desire to establish a permanent gender role as a member of the gender with which they identify, and many transsexual people pursue medical interventions as part of the process of expressing their gender. The entire process of switching from one physical sex and social gender presentation to another is often referred to as transitioning, and usually takes several years. Transsexual people who transition usually change their social gender roles, legal names and legal sex designation.^{[citation needed]}

Not all transsexual people undergo a physical transition. Some have obstacles or concerns preventing them from doing so, such as the expense of surgery, the risk of medical complications, or medical conditions which make the use of hormones or surgery dangerous. Others may not identify strongly with another binary gender role. Still others may find balance at a midpoint during the process, regardless of whether or not they are binary-identified. Many transsexual people, including binary-identified transsexual people, do not undergo genital surgery, because they are comfortable with their own genitals, or because they are concerned about nerve damage and the potential loss of sexual pleasure, including orgasm. This is especially so in the case of trans men, many of whom are dissatisfied with the current state of phalloplasty, which is typically very expensive, not covered by health insurance, and commonly does not achieve desired results. For example, not only does phalloplasty not result in a completely natural erection, it may not allow for an erection at all, and its results commonly lack penile sexual sensitivity; in other cases, however, phalloplasty results are satisfying for trans men. By contrast, metoidioplasty, which is more popular, is significantly less expensive and has far better sexual results.^[5][6][7]

Transsexual people can be heterosexual, gay, lesbian, or bisexual; many choose the language of how they refer to their sexual orientation based on their gender identity, not their birth assigned sex.^[8]

Psychological treatment

Psychological techniques that attempt to alter gender identity to one considered appropriate for the person's assigned sex, aka conversion therapy, are ineffective. The widely recognized Standards of Care note that sometimes the only reasonable and effective course of treatment for transsexual people is to go through sex reassignment therapy.^[3][9]

The need for treatment of transsexual people is emphasized by the high rate of mental health problems, including depression, anxiety, and various addictions, as well as a higher suicide rate among untreated transsexual people than in the general population.^[10] These problems are alleviated by a change of gender role and/or physical characteristics.^[11]

Many transgender and transsexual activists, and many caregivers, note that these problems are not usually related to the gender identity issues themselves, but the social and cultural responses to gender-variant individuals. Some transsexual people reject the counseling that is recommended by the Standards of Care^[3] because they do not consider their gender identity to be a cause of psychological problems.

Brown and Rounsley noted that "some transsexual people acquiesce to legal and medical expectations in order to gain rights granted through the medical/psychological hierarchy." Legal needs, such as a change of sex on legal documents, and medical needs, such as sex reassignment surgery, are usually difficult to obtain without a doctor or therapist's approval. Because of this, some transsexual people feel coerced into affirming outdated concepts of gender to overcome simple legal and medical hurdles.^[12]

Regrets and detransitions

See also: Detransition

People who undergo sex reassignment surgery can develop regret for the procedure later in life, largely predicted by a lack of support from family or peers, with data from the 1990s suggesting a rate of 3.8%.^[13][14] In a 2001 study of 232 MTF patients who underwent GRS, none of the patients reported complete regret and only 6% reported partial or occasional regrets.^[15] A 2009 review of Medline literature suggests the total rate of patients expressing feelings of doubt or regret is estimated to be as high as 8%.^[16]

A 2010 meta-study, based on 28 previous long-term studies of transsexual men and women, found that the overall psychological functioning of transsexual people after transition was similar to that of the general population and significantly better than that of untreated transsexual people.^[17]

Prevalence

See also: Transgender § Population figures and prevalence

Estimates of the prevalence of transsexual people are highly dependent on the specific case definitions used in the studies, with prevalence rates varying by orders of magnitude.^[18] In the United States, the Diagnostic and Statistical Manual of Mental Disorders (DSM-V 2013) gives the following estimates: "For natal adult males [MTF], prevalence ranges from 0.005% to 0.014%, and for natal females [FTM], from 0.002% to 0.003%." It states, however, that these are likely underestimates since the figures are based on referrals to specialty clinics.^[19]

The Amsterdam Gender Dysphoria Clinic over four decades has treated roughly 95% of Dutch transsexual clients, and it suggests (1997) a prevalence of 1:10,000 among assigned males and 1:30,000 among assigned females.^[20]

Olyslager and Conway presented a paper^[21] at the WPATH 20th International Symposium (2007) arguing that the data from their own and other studies actually imply much higher prevalence, with minimum lower bounds of 1:4,500 male-to-female transsexual people and 1:8,000 female-to-male transsexual people for a number of countries worldwide. They estimate the number of post-op women in the US to be 32,000 and obtain a figure of 1:2500 male-to-female transsexual people. They further compare the annual instances of sex reassignment surgery (SRS) and male birth in the U.S. to obtain a figure of 1:1000 MTF transsexual people and suggest a prevalence of 1:500 extrapolated from the rising rates of SRS in the US and a "common sense" estimate of the number of undiagnosed transsexual people. Olyslager and Conway also argue that the US population of assigned males having already undergone reassignment surgery by the top three US SRS surgeons alone is enough to account for the entire transsexual population implied by the 1:10,000 prevalence number, yet this excludes all other US SRS surgeons, surgeons in countries such as Thailand, Canada, and others, and the high proportion of transsexual people who have not yet sought treatment, suggesting that a prevalence of 1:10,000 is too low.

A 2008 study of the number of New Zealand passport holders who changed the sex on their passport estimated that 1:3,639 birth-assigned males and 1:22,714 birth-assigned females were transsexual.^[22]

A 2008 presentation at the LGBT Health Summit in Bristol, UK,^[23] showed that the prevalence of transsexual people in the UK was increasing (14% per year) and that the mean age of transition was rising.

Though no direct studies on the prevalence of gender identity disorder (GID) have been done, a variety of clinical papers published in the past 20 years provide estimates ranging from 1:7,400 to 1:42,000 in assigned males and 1:30,040 to 1:104,000 in assigned females.^[24]

In 2015, the National Center for Transgender Equality conducted a National Transgender Discrimination Survey. Of the 27,715 transgender and genderqueer people who took the survey, 35% identified as "non-binary", 33% identified as transgender women, 29% identified as transgender men, and 3% said that "crossdresser" best described their gender identity.^[25][26]

A 2016 systematic review and meta-analysis of "how various definitions of transgender affect prevalence estimates" in 27 studies found a meta-prevalence (mP) estimates per 100,000 population of 9.2 (95% CI = 4.9–13.6), equal to 1:11,000 for surgical or hormonal gender affirmation therapy and 6.8 (95% CI = 4.6–9.1), equal to 1:15,000 for transgender-related medical condition diagnoses. Of studies assessing self-reported transgender identity, prevalence was 355 (95% CI = 144–566), equal to 1 in 282. However, a single outlier study would have influenced the result to 871 (95% CI = 519–1,224), equal to 1 in 115; this study was removed. "Significant heterogeneity was observed in most analyses."^[18]

Country	Publication	Year	Incidence in males	Incidence in females
US	DSM-IV	1994	1:30,000	1:100,000
Netherlands	The Journal of Clinical Endocrinology & Metabolism	1997	1:10,000	1:30,000
US	International Journal of Transgenderism	2007	1:4,500	1:8,000
New Zealand	Australian and New Zealand Journal of Psychiatry	2008	1:3,639	1:22,714
US	The Journal of Sexual Medicine	2016	1:11,000	1:15,000

Society and culture

A number of Native American and First Nations cultures have traditional social and ceremonial roles for individuals who do not fit into the usual roles for males and females in that culture. These roles can vary widely between tribes, because gender roles, when they exist at all, also vary considerably among different Native cultures. However, a modern, pan-Indian status known as Two-Spirit has emerged among LGBT Natives in recent years.^[27]

Legal and social aspects

See also: Legal aspects of transsexualism

 

Poland's Anna Grodzka^[28] is the first transsexual MP in the history of Europe to have had sex reassignment surgery.^[29]

Laws regarding changes to the legal status of transsexual people are different from country to country. Some jurisdictions allow an individual to change their name, and sometimes, their legal gender, to reflect their gender identity. Within the US, some states allow amendments or complete replacement of the original birth certificates.^[30] Some states seal earlier records against all but court orders in order to protect the transsexual person's privacy.

In many places, it is not possible to change birth records or other legal designations of sex, although changes are occurring. Estelle Asmodelle's book documented her struggle to change the Australian birth certificate and passport laws, although there are other individuals who have been instrumental in changing laws and thus attaining more acceptance for transsexual people in general.

Medical treatment for transsexual and transgender people is available in most Western countries. However, transsexual and transgender people challenge the "normative" gender roles of many cultures and often face considerable hatred and prejudice. The film Boys Don't Cry chronicles the case of Brandon Teena, a transsexual man who was raped and murdered after his status was discovered. In 1999 Brandon was memoralised in the first Transgender Day of Remembrance.^[31] The Transgender Day of Rembrance is observed annually on November 20 by members of the transgender community and LGBT+ organisations across the world.^[32][33]

Jurisdictions allowing changes to birth records generally allow trans people to marry members of the opposite sex to their gender identity and to adopt children. Jurisdictions which prohibit same sex marriage often require pre-transition marriages to be ended before they will issue an amended birth certificate.^[34]

Health-practitioner manuals, professional journalistic style guides, and LGBT advocacy groups advise the adoption by others of the name and pronouns identified by the person in question, including present references to the transgender or transsexual person's past.^[35][36][37] Family members and friends who may be confused about pronoun usage or the definitions of sex are commonly instructed in proper pronoun usage, either by the transsexual person or by professionals or other persons familiar with pronoun usage as it relates to transsexual people. Sometimes transsexual people have to correct their friends and family members many times before they begin to use the transsexual person's desired pronouns consistently. According to Julia Serano, deliberate mis-gendering of transsexual people is "an arrogant attempt to belittle and humiliate trans people."^[38]

Both "transsexualism" and "gender identity disorders not resulting from physical impairments" are specifically excluded from coverage under the Americans with Disabilities Act Section 12211.^[39] Gender dysphoria is not excluded.^[40]

Employment issues

Openly transsexual people can have difficulty maintaining employment. Most find it necessary to remain employed during transition in order to cover the costs of living and transition. However, employment discrimination against trans people is rampant and many of them are fired when they come out or are involuntarily outed at work.^[41] Transsexual people must decide whether to transition on-the-job, or to find a new job when they make their social transition. Other stresses that transsexual people face in the workplace are being fearful of coworkers negatively responding to their transition, and losing job experience under a previous name—even deciding which rest room to use can prove challenging.^[42] Finding employment can be especially challenging for those in mid-transition.

Laws regarding name and gender changes in many countries make it difficult for transsexual people to conceal their trans status from their employers.^[43] Because the Harry Benjamin Standards of Care requires one-year of real life experience prior to SRS, some feel this creates a Catch-22 situation which makes it difficult for trans people to remain employed or obtain SRS.

In many countries, laws provide protection from workplace discrimination based on gender identity or gender expression, including masculine women and feminine men. An increasing number of companies are including "gender identity and expression" in their non-discrimination policies.^[30][44] Often these laws and policies do not cover all situations and are not strictly enforced. California's anti-discrimination laws protect transsexual persons in the workplace and specifically prohibit employers from terminating or refusing to hire a person based on their gender identity. The European Union provides employment protection as part of gender discrimination protections following the European Court of Justice decisions in P v S and Cornwall County Council.^[45]

In the United States National Transgender Discrimination Survey, 44% of respondents reported not getting a job they applied for because of being transgender.^[26] 36% of trans women reported losing a job due to discrimination compared to 19% of trans men.^[26] 54% of trans women and 50% of trans men report having been harassed in the workplace.^[26] Transgender people who have been fired due to bias are more than 34 times likely than members of the general population to attempt suicide.^[26]

Stealth

Many transsexual men and women choose to live completely as members of their gender without disclosing details of their birth-assigned sex. This approach is sometimes called stealth.^[46] Stealth transsexuals choose not to disclose their past for numerous reasons, including fear of discrimination and fear of physical violence.^[26]: 63 There are examples of people having been denied medical treatment upon discovery of their trans status, whether it was revealed by the patient or inadvertently discovered by the doctors.^[47]

In the media

 

Nina Poon, a transsexual model who has appeared in Kenneth Cole ads, at the 2010 Tribeca Film Festival

See also: Media portrayals of transgender people

Before transsexual people were depicted in popular movies and television shows, Aleshia Brevard—a transsexual woman whose surgery took place in 1962^[48]: 3—was actively working as an actress^[48]: 141 and model^[48]: 200 in Hollywood and New York throughout the 1960s and 1970s. Aleshia never portrayed a transsexual person, though she appeared in eight Hollywood-produced films, on most of the popular variety shows of the day, including The Dean Martin Show, and was a regular on The Red Skelton Show and One Life to Live before returning to university to teach drama and acting.^{[48][49][user-generated source]}

In pageantry

Since 2004, with the goal of crowning the top transsexual of the world, a beauty pageant by the name of The World's Most Beautiful Transsexual Contest was held in Las Vegas, Nevada. The pageant accepted pre-operation and post-operation trans women, but required proof of their gender at birth. The winner of the 2004 pageant was a woman named Mimi Marks.^[50]

Jenna Talackova, the 23-year-old woman who forced Donald Trump and his Miss Universe Canada pageant to end its ban on transgender contestants, competed in the pageant on May 19, 2012, in Toronto.^[51] On January 12, 2013, Kylan Arianna Wenzel was the first transgender woman allowed to compete in a Miss Universe Organization pageant since Donald Trump changed the rules to allow women like Wenzel to enter officially. Wenzel was the first transgender woman to compete in a Miss Universe Organization pageant since officials disqualified 23-year-old Miss Canada Jenna Talackova the previous year after learning she was transgender.^[52][53]

See also

•  Transgender portal
•  Human sexuality portal

• List of transgender-related topics
• List of transgender-rights organizations
• List of LGBT-related organizations
• List of transgender people
• Transgender

References

1. Serano, Julia (2016). Whipping girl : a transsexual woman on sexism and the scapegoating of femininity (2 ed.). Berkeley, CA. pp. 233–245. ISBN 978-1-58005-622-9. OCLC 920728057.{{cite book}}: CS1 maint: location missing publisher (link)
2. Cite error: The named reference WPATH web was invoked but never defined (see the help page).
3. Cite error: The named reference WPATHSOCs was invoked but never defined (see the help page).
4. Gooren, LJ; Giltay, EJ; Bunck, MC (2008). "Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience". J Clin Endocrinol Metab. 93 (1): 19–25. doi:10.1210/jc.2007-1809. PMID 17986639.
5. Teich, Nicholas (2012). Transgender 101: A Simple Guide to a Complex Issue. Columbia University Press. p. 55. ISBN 978-0231504270. from the original on 20 September 2015. Retrieved 20 August 2015. Historically, many transmen who have had phalloplasty have not been satisfied with the results. Doctors continue to make improvements to this surgery, but many surgeons in the United States choose not to perform it because of the high risk of complications (severe scarring or fistulas for example), the significant risk of never regaining sensation in the penis or donor sites, and the chance that the result will not be aesthetically pleasing. However, some transmen are satisfied with their results and would choose to do it again if given the choice.
6. Stryker, Susan; Whittle, Stephen (2013). The Transgender Studies Reader. Routledge. p. 353. ISBN 978-1135398842. from the original on 10 September 2015. Retrieved 20 August 2015. In addition, phalloplasty 'cannot produce an organ rich in the sexual feeling of the natural one.'
7. Carroll, Janell (2015). Sexuality Now: Embracing Diversity. Routledge. p. 132. ISBN 978-1305446038. from the original on 20 September 2015. Retrieved 20 August 2015. Penises made from phalloplasty cannot achieve a natural erection, so penile implants of some kind are usually used (we will discuss these implants in more detail in Chapter 14). Overall, metoidioplasty is a simpler procedure than phalloplasty, which explains its popularity. It also has fewer complications, takes less time, and is less expensive (e.g., a metoidioplasty takes about 1 to 2 hours and can cost around $15,000 to 20,000, whereas, a phalloplasty can take about 8 hours can cost more than $65,000).
8. Cite error: The named reference ekins2006 was invoked but never defined (see the help page).
9. Moore, Eva; Wisniewski, Amy; Dobs, Adrian (2003). . The Journal of Clinical Endocrinology & Metabolism. 88 (8): 3467–3473. doi:10.1210/jc.2002-021967. PMID 12915619. Archived from the original on 16 February 2007. Retrieved 4 July 2021.
10. . 18 August 2000. Archived from the original on 18 August 2000.
11. De Cuypere, Greta (2006). "Long-term follow-up: psychosocial outcome of Belgian transsexuals after sex reassignment surgery". Sexologies. 15 (2): 126–133. doi:10.1016/j.sexol.2006.04.002. ...the suicide attempt rate dropped significantly from 29.3% to 5.1%
12. Brown, Mildred L. (2003). True selves : understanding transsexualism-- for families, friends, coworkers, and helping professionals. Chloe Ann Rounsley (1 paperback ed.). San Francisco: Jossey-Bass. p. 107. ISBN 0-7879-6702-5. OCLC 51437864.
13. Landén, M; Wålinder, J; Hambert, G; Lundström, B. (April 1998). "Factors predictive of regret in sex reassignment". Acta Psychiatr Scand. 97 (4): 284–9. doi:10.1111/j.1600-0447.1998.tb10001.x. PMID 9570489. S2CID 19652697.
14. Stark, Jill (31 May 2009). "I will never be able to have sex again. Ever". The Age. from the original on 9 April 2010.
15. Lawrence, A. A. (August 2003). "Factors associated with satisfaction or regret following male-to-female sex reassignment surgery". Archives of Sexual Behavior. 32 (4): 299–315. doi:10.1023/A:1024086814364. PMID 12856892. S2CID 9960176.
16. Baranyi, A; Piber, D; Rothenhäusler, HB. (2009). "Male-to-female transsexualism. Sex reassignment surgery from a biopsychosocial perspective". Wien Med Wochenschr. 159 (21–22): 548–57. doi:10.1007/s10354-009-0693-5. PMID 19997841.
17. Murad, Mohammad; Elamin, Mohomed; Garcia, Magaly; Mullan, Rebecca; Murad, Ayman; Erwin, Patricia; Montori, Victor (2010). "Hormonal therapy and sex reassignment: a systematic review and meta-analysis of quality of life and psychosocial outcomes". Clinical Endocrinology. 72 (2): 214–231. doi:10.1111/j.1365-2265.2009.03625.x. PMID 19473181. S2CID 19590739.
18. Collin, Lindsay; Reisner, Sari L; Tangpricha, Vin; Goodman, Michael (1 April 2016). "Prevalence of Transgender Depends on the "Case" Definition: A Systematic Review". The Journal of Sexual Medicine. 13 (4): 613–626. doi:10.1016/j.jsxm.2016.02.001. PMC 4823815. PMID 27045261. Retrieved 4 July 2021.
19. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Washington, D.C.: American Psychiatric Association. 2013. p. 454. ISBN 978-0890425541.
20. van Kesteren, Paul J. M; Asscheman, Henk; Megens, Jos A. J; Gooren, Louis J. G (1997). "Mortality and morbidity in transsexual subjects treated with cross-sex hormones". J. Clin. Endocrinol. 47 (3): 337–343. doi:10.1046/j.1365-2265.1997.2601068.x. PMID 9373456. S2CID 12126434.
21. Olyslager, Femke; Conway, Lynn (2007). On the Calculation of the Prevalence of Transsexualism (PDF) (Report). (PDF) from the original on 27 February 2008. Retrieved 11 December 2007.
22. Veale, Jaimie F. (October 2008). (PDF). Australian and New Zealand Journal of Psychiatry. 42 (10): 887–889. doi:10.1080/00048670802345490. PMID 18777233. S2CID 205398433. Archived from the original (PDF) on 28 March 2012. Retrieved 27 July 2011.
23. Reed, Bernard; Rhodes, Stephenne (2008). . Archived from the original on 9 March 2009.
24. Kaplan, Ami B. (31 March 2010). "The Prevalence of Transgenderism". Transgender Mental Health. from the original on 23 August 2010. Retrieved 12 June 2022.
25. (PDF). National Center for Transgender Equality. 2016. Archived from the original (PDF) on 9 December 2016. Retrieved 6 March 2016.
26. Grant, Jaime M.; Mottet, Lisa A.; Tanis, Justin; Harrison, Jack; Heman, Jody L.; Keisling, Mara (2011). (PDF) (Report). National Center for Transgender Equality and National LGBTQ Task Force. Archived from the original (PDF) on 6 May 2015. Retrieved 31 May 2021.
27. Gilley, Brian Joseph (2006). Becoming two-spirit : gay identity and social acceptance in Indian country. Lincoln. ISBN 0-8032-5797-X. OCLC 75428414.{{cite book}}: CS1 maint: location missing publisher (link)
28. "Anna Grodzka". Sejm (in Polish). from the original on 26 April 2012. Retrieved 2 December 2011.
29. Świerzowski, Bogusław (10 October 2011). "Wybory 2011: Andrzej Duda (PIS) zdeklasował konkurentów w Krakowie". Info Krakow 24 (in Polish). from the original on 4 September 2015.
30. "The Transgender Law and Policy Institute: Home Page". Transgenderlaw.org. Archived from the original on 15 April 2013. Retrieved 6 July 2011.
31. Ann Smith, Gwendolyn (20 November 2012). "Transgender Day of Remembrance: Why We Remember". HuffPost. Retrieved 12 June 2022.
32. "Trans Day of Remembrance Nov 20". GLAAD. 8 November 2019. Retrieved 12 June 2022.
33. "Trans Day of Remembrance Campaign". Transgender Europe. Retrieved 12 June 2022.
34. "When Albert met Ann: 'Ridiculous' marriage laws force transgender divorce". The Age. 28 December 2014. from the original on 24 April 2017. Retrieved 23 August 2015.
35. Glicksman, Eve (April 2013). "Transgender terminology: It's complicated". Monitor on Psychology. American Psychological Association. 44 (4): 39. from the original on 25 September 2013. Retrieved 17 September 2013. Use whatever name and gender pronoun the person prefers
36. "Meeting the Health Care Needs of Lesbian, Gay, Bisexual, and Transgender (LGBT) People: The End to LGBT Invisibility" (PowerPoint Presentation). The Fenway Institute. p. 24. from the original on 20 October 2013. Retrieved 17 September 2013. Use the pronoun that matches the person's gender identity
37. (PDF). Preface: Fenway Health. January 2010. p. 2. Archived from the original (PDF) on 19 October 2013. Retrieved 17 September 2013. listen to your clients – what terms do they use to describe themselves
38. Serano, Julia (2009). Whipping Girl: A Transsexual Woman on Sexism and the Scapegoating of Femininity. Seal Press. ISBN 978-1-58005-154-5. Retrieved 31 May 2021.
39. . find US law. Archived from the original on 27 December 2011. Retrieved 6 July 2011.
40. . United States Access Board, a Federal Agency. 1 January 2009. Archived from the original on 20 July 2013. Retrieved 5 June 2013.
41. James, Andrea (4 April 2019). "Transgender employment". Transgender Map. from the original on 2 June 2022. Retrieved 12 June 2022.
42. Pepper 2008
43. Weiss, Jillian Todd (2001). "The Gender Caste System: Identity, Privacy and Heteronormativity" (PDF). Law & Sexuality. Tulane Law School. Archived from the original (PDF) on 21 June 2007. Retrieved 25 February 2007.
44. . Human Rights Campaign. 2004. Archived from the original on 31 October 2006.
45. "Judgment of the Court of 30 April 1996. - P v S and Cornwall County Council". 30 April 1996. Retrieved 12 June 2022.
46. Schilt, Kristen (2006). "Just One of the Guys?". Gender & Society. SAGE Publications. 20 (4): 465–490. doi:10.1177/0891243206288077. ISSN 0891-2432. S2CID 144778992.
47. Stryker, Susan; Whittle, Stephen (2006). The Transgender Studies Reader. CRC Press. ISBN 9780415947091. from the original on 3 February 2016. Retrieved 24 November 2009.
48. Brevard, Aleshia (19 January 2011). Woman I Was Not Born To Be: A Transsexual Journey. Philadelphia: Temple University Press. ISBN 978-1-4399-0527-2. OCLC 884015871. from the original on 26 October 2020. Retrieved 20 October 2016.
49. Aleshia Brevard at IMDb
50. Forman, Ross (27 January 2021). "Chicago Performer Mimi Marks Reflects on Her Award-Winning Career". Go Pride. from the original on 21 April 2021. Retrieved 4 July 2021.
51. Newton, Paula (21 May 2012). "Transgender Miss Universe Canada contestant falls short of title". CNN. from the original on 4 March 2016. Retrieved 29 August 2015.
52. Bennettsmith, Meredith (11 January 2013). "Transgender Miss California Contestant Set To Make History". Huffington Post. from the original on 3 February 2014. Retrieved 26 August 2014.
53. . LGBT Weekly. Archived from the original on 12 September 2015. Retrieved 29 August 2015.

Bibliography

• Benjamin, Harry (1966). The Transsexual Phenomenon. Julian Press, Incorporated Publishers. OCLC 1138665289.
• Brown, Mildred L.; Chloe Ann Rounsley (1996). True Selves: Understanding Transsexualism – For Families, Friends, Coworkers, and Helping Professionals. Jossey-Bass. ISBN 978-0-7879-6702-4. OCLC 51437864.
• Feinberg, Leslie (1999). Trans Liberation : Beyond Pink or Blue. Beacon Press. ISBN 978-0-8070-7951-5. OCLC 38732343.
• Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People (PDF) (Report). 7. World Professional Association for Transgender Health. 2012. (PDF) from the original on 11 May 2022.
• Kruijver, Frank P. M.; Zhou, Jiang-Ning; Pool, Chris W.; Hofman, Michel A.; Gooren, Louis J. G.; Swaab, Dick F. (1 May 2000). "Male-to-Female Transsexuals Have Female Neuron Numbers in a Limbic Nucleus". The Journal of Clinical Endocrinology and Metabolism. The Endocrine Society. 85 (5): 2034–41. doi:10.1210/jcem.85.5.6564. ISSN 0021-972X. PMID 10843193. from the original on 6 February 2007. Retrieved 25 February 2007.
• Rathus, Spencer A.; Jeffery S. Nevid, Lois Fichner-Rathus (2002). Human Sexuality in a World of Diversity. Allyn & Bacon. ISBN 978-0-205-40615-9. OCLC 55502508.
• Schreiber, Gerhard (2016). Transsexuality in Theology and Neuroscience. Findings, Controversies, and Perspectives (in German). Walter de Gruyter. ISBN 978-3-11-044080-5. OCLC 962412457.
• Pepper, Shanti M.; Lorah, Peggy (2008). "Career Issues and Workplace Considerations for the Transsexual Community: Bridging a Gap of Knowledge for Career Counselors and Mental Health Care Providers". The Career Development Quarterly. Wiley. 56 (4): 330–343. doi:10.1002/j.2161-0045.2008.tb00098.x. ISSN 0889-4019. ProQuest 219546491.

External links

 

Look up transsexual in Wiktionary, the free dictionary.

•  – The Official Journal of the World Professional Association for Transgender Health (formerly HBIGDA). is available, as are , including Harry Benjamin's The Transsexual Phenomenon