The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access website, acting as a portal to information on the biological targets of licensed drugs and other small molecules. The Guide to PHARMACOLOGY (with GtoPdb being the standard abbreviation) is developed as a joint venture between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). This replaces and expands upon the original 2009 IUPHAR Database (standard abbreviation IUPHAR-DB). The Guide to PHARMACOLOGY aims to provide a concise overview of all pharmacological targets, accessible to all members of the scientific and clinical communities and the interested public, with links to details on a selected set of targets. The information featured includes pharmacological data, target, and gene nomenclature, as well as curated chemical information for ligands. Overviews and commentaries on each target family are included, with links to key references.
IUPHAR/BPS Guide to PHARMACOLOGY
Content
Description
An online, open-access portal to pharmacological information on all the human targets of prescription drugs
The Guide to PHARMACOLOGY was initially made available online in December 2011 with additional material released in July 2012. Maintained by a team of curators based at the University of Edinburgh, the Guide to PHARMACOLOGY is developed by an international network of contributors, including the editors of the Concise Guide to PHARMACOLOGY. As with the original IUPHAR-DB, the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), acts as the scientific advisory and editorial board for the database. Its network of over 500 specialist advisors (organized into ~90 subcommittees) contribute expertise and data. The current PI and Grant holder of the GtoPdb project is Prof. Jamie A. Davies. The development and release of the first version of the GtoPdb in 2012 were described in an editorial published in the British Journal of Pharmacology entitled 'Guide to Pharmacology.org- an update'.[2] The IUPHAR-DB is no longer being developed and all the information contained within this site is now available through the Guide to PHARMACOLOGY (IUPHAR-DB links should now re-direct).
Content and features
The target groups currently included on the Guide to PHARMACOLOGY are:
Information for each target group is subdivided into families based on classification, with a separate data page for each family. Within each page, targets are arranged into lists of tables, with each table including the protein and gene nomenclature for the target with links to gene nomenclature databases, and listing selected ligands with activity at the target, including agonists, antagonists, inhibitors and radioligands. Pharmacological data and references are given and each ligand is hyperlinked to a ligand page displaying nomenclature and a chemical structure or peptide sequence, along with synonyms and relevant database links. The Guide to PHARMACOLOGY also includes a list of all ligand molecules included on the site, subdivided into categories including small organic molecules (including mammalian metabolites, hormones and neurotransmitters), synthetic organic molecules, natural products, peptides, inorganic molecules and antibodies. A complete list of all the approved drugs included on the website is also available via the ligand list. The Guide to PHARMACOLOGY is being expanded to include clinical information on targets and ligands, in addition to educational resources. Search features on the website include quick and advanced search options, and receptor and ligand searches, including support for ligand structures using chemical structures. Other features include 'Hot topic' news items and a recent receptor-ligand pairing list.
IUPHAR Guide to IMMUNOPHARMACOLOGY
Between November 2015 and October 2018, the Wellcome Trust supported a project to develop the IUPHAR Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb), based on the GtoPdb schema. The GtoImmuPdb is an open-access resource that brings an immunological perspective to the high-quality, expert-curated pharmacological data found in the existing IUPHAR/BPS Guide to PHARMACOLOGY. Protein targets and ligands relevant to immunopharmacology have been tagged and curated into GtoImmuPdb. These have also been associated with new immunological data types such as immunological processes, cell types, and disease. GtoImmuPdb provides a knowledge base that connects immunology with pharmacology, bringing added value and supporting research and development of drugs targeted at modulating immune, inflammatory or infectious components of the disease.[3]
The Concise Guide to PHARMACOLOGY
The Guide to PHARMACOLOGY includes an online, open-access database version of the Concise Guide to PHARMACOLOGY, previously "The Guide to Receptors and Channels"[4] available in HTML, PDF and printed formats. A hard copy summary of the online database is published as The Concise Guide to Pharmacology 2017/2018[5] as a series of papers as a bi-annual supplement to the British Journal of Pharmacology.
Database links
The Guide to PHARMACOLOGY includes links to other relevant resources via target and ligand pages on both the concise and detailed view pages. Many of these resources maintain reciprocal links with the relevant Guide to PHARMACOLOGY pages.
Following funding from the Wellcome Trust, from 2012 to 2015 the Guide to PHARMACOLOGY was expanded to include the biological targets of all prescription drugs and other likely targets of future small molecule drugs. Overviews of the key features of a wide range of targets are provided on the summary view pages, with detailed view pages providing more in-depth information on the properties of a selected subset of targets. As of January 2018 the Medicines for Malaria Venture is supporting a new extension to develop the Guide to Malaria Pharmacology. The core GtoPdb continues to be supported by the British Pharmacological Society.
^Armstrong, JF; Faccenda, E; Harding, SD; Pawson, AJ; Southan, C; Sharman, JL; Campo, B; Cavanagh, DR; Alexander, SPH; Davenport, AP; Spedding, M; Davies, JA (8 January 2020). "The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY". Nucleic Acids Research. 48 (D1): D1006–D1021. doi:10.1093/nar/gkz951. PMC7145572. PMID 31691834.
^Alexander, S. P.; Benson, H. E.; Davenport, A.; Mathie, A.; McGrath, I. J.; Pawson, A. J.; Peters, J. A.; Sharman, J. L.; Spedding, M.; Harmar, A. J. (2012). "GuideToPharmacology.org - an update". British Journal of Pharmacology. 167 (4): 697–698. doi:10.1111/j.1476-5381.2012.02141.x. PMC3575771. PMID 23003568.
^Harding, SD; Faccenda, E; Southan, C; Maffia, P; Davies, JA (December 2018). "A new guide to immunopharmacology". Nature Reviews. Immunology. 18 (12): 729. doi:10.1038/s41577-018-0079-2. PMID 30327546.
^Alexander, SP; Mathie, A; Peters, JA (November 2011). "Guide to Receptors and Channels (GRAC), 5th edition". British Journal of Pharmacology. 164 Suppl 1 (Suppl 1): S1–324. doi:10.1111/j.1476-5381.2011.01649_1.x. PMC3315626. PMID 22040146.
^Alexander, SP; Kelly, E; Marrion, NV; Peters, JA; Faccenda, E; Harding, SD; Pawson, AJ; Sharman, JL; Southan, C; Buneman, OP; Cidlowski, JA; Christopoulos, A; Davenport, AP; Fabbro, D; Spedding, M; Striessnig, J; Davies, JA; CGTP, Collaborators. (December 2017). "THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview". British Journal of Pharmacology. 174 Suppl 1 (Suppl Suppl 1): S1–S16. doi:10.1111/bph.13882. PMC5650665. PMID 29055037. {{cite journal}}: |first18= has generic name (help)
External links
IUPHAR/BPS Guide to PHARMACOLOGY
2021 edition of the IUPHAR/BPS Guide to PHARMACOLOGY (published in BJP)
International Union of Basic and Clinical Pharmacology (IUPHAR)
British Journal of Pharmacology
Concise Guide to PHARMACOLOGY
Wellcome Trust
Medicines for Malaria Venture
January 20, 2023
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The IUPHAR BPS Guide to PHARMACOLOGY is an open access website acting as a portal to information on the biological targets of licensed drugs and other small molecules The Guide to PHARMACOLOGY with GtoPdb being the standard abbreviation is developed as a joint venture between the International Union of Basic and Clinical Pharmacology IUPHAR and the British Pharmacological Society BPS This replaces and expands upon the original 2009 IUPHAR Database standard abbreviation IUPHAR DB The Guide to PHARMACOLOGY aims to provide a concise overview of all pharmacological targets accessible to all members of the scientific and clinical communities and the interested public with links to details on a selected set of targets The information featured includes pharmacological data target and gene nomenclature as well as curated chemical information for ligands Overviews and commentaries on each target family are included with links to key references IUPHAR BPS Guide to PHARMACOLOGYContentDescriptionAn online open access portal to pharmacological information on all the human targets of prescription drugsData typescapturedTarget nomenclature pharmacological data ligand structuresOrganismsHuman Mouse RatContactResearch centreUniversity of Edinburgh UKPrimary citationThe IUPHAR BPS Guide to PHARMACOLOGY in 2020 extending immunopharmacology content and introducing the IUPHAR MMV Guide to MALARIA PHARMACOLOGY 1 AccessWebsitewww wbr guidetopharmacology wbr orgWeb service URLwww wbr guidetopharmacology wbr org wbr webServices wbr jspSparql endpointrdf wbr guidetopharmacology wbr org wbr sparqlMiscellaneousVersioningContent updated approx quarterly i e 2020 2 indicates year release number Curation policyManual in house Contents 1 Background and development 2 Content and features 3 IUPHAR Guide to IMMUNOPHARMACOLOGY 4 The Concise Guide to PHARMACOLOGY 5 Database links 6 Future directions 7 See also 8 References 9 External linksBackground and development EditThe Guide to PHARMACOLOGY was initially made available online in December 2011 with additional material released in July 2012 Maintained by a team of curators based at the University of Edinburgh the Guide to PHARMACOLOGY is developed by an international network of contributors including the editors of the Concise Guide to PHARMACOLOGY As with the original IUPHAR DB the International Union of Basic and Clinical Pharmacology IUPHAR Committee on Receptor Nomenclature and Drug Classification NC IUPHAR acts as the scientific advisory and editorial board for the database Its network of over 500 specialist advisors organized into 90 subcommittees contribute expertise and data The current PI and Grant holder of the GtoPdb project is Prof Jamie A Davies The development and release of the first version of the GtoPdb in 2012 were described in an editorial published in the British Journal of Pharmacology entitled Guide to Pharmacology org an update 2 The IUPHAR DB is no longer being developed and all the information contained within this site is now available through the Guide to PHARMACOLOGY IUPHAR DB links should now re direct Content and features EditThe target groups currently included on the Guide to PHARMACOLOGY are Catalytic receptors Enzymes G protein coupled receptors Ion channels Kinases Nuclear receptors Transporters Other protein targets including fatty acid binding proteins sigma receptors and adiponectin receptorsInformation for each target group is subdivided into families based on classification with a separate data page for each family Within each page targets are arranged into lists of tables with each table including the protein and gene nomenclature for the target with links to gene nomenclature databases and listing selected ligands with activity at the target including agonists antagonists inhibitors and radioligands Pharmacological data and references are given and each ligand is hyperlinked to a ligand page displaying nomenclature and a chemical structure or peptide sequence along with synonyms and relevant database links The Guide to PHARMACOLOGY also includes a list of all ligand molecules included on the site subdivided into categories including small organic molecules including mammalian metabolites hormones and neurotransmitters synthetic organic molecules natural products peptides inorganic molecules and antibodies A complete list of all the approved drugs included on the website is also available via the ligand list The Guide to PHARMACOLOGY is being expanded to include clinical information on targets and ligands in addition to educational resources Search features on the website include quick and advanced search options and receptor and ligand searches including support for ligand structures using chemical structures Other features include Hot topic news items and a recent receptor ligand pairing list IUPHAR Guide to IMMUNOPHARMACOLOGY EditBetween November 2015 and October 2018 the Wellcome Trust supported a project to develop the IUPHAR Guide to IMMUNOPHARMACOLOGY GtoImmuPdb based on the GtoPdb schema The GtoImmuPdb is an open access resource that brings an immunological perspective to the high quality expert curated pharmacological data found in the existing IUPHAR BPS Guide to PHARMACOLOGY Protein targets and ligands relevant to immunopharmacology have been tagged and curated into GtoImmuPdb These have also been associated with new immunological data types such as immunological processes cell types and disease GtoImmuPdb provides a knowledge base that connects immunology with pharmacology bringing added value and supporting research and development of drugs targeted at modulating immune inflammatory or infectious components of the disease 3 The Concise Guide to PHARMACOLOGY EditThe Guide to PHARMACOLOGY includes an online open access database version of the Concise Guide to PHARMACOLOGY previously The Guide to Receptors and Channels 4 available in HTML PDF and printed formats A hard copy summary of the online database is published as The Concise Guide to Pharmacology 2017 2018 5 as a series of papers as a bi annual supplement to the British Journal of Pharmacology Database links EditThe Guide to PHARMACOLOGY includes links to other relevant resources via target and ligand pages on both the concise and detailed view pages Many of these resources maintain reciprocal links with the relevant Guide to PHARMACOLOGY pages HUGO Gene Nomenclature Committee Mouse Genome Informatics Rat genome database Ensembl UniProt Entrez PubChem ChemSpider ChEMBL ChEBI KEGG Online Mendelian Inheritance in Man OMIM DrugBank Protein Data BankFuture directions EditFollowing funding from the Wellcome Trust from 2012 to 2015 the Guide to PHARMACOLOGY was expanded to include the biological targets of all prescription drugs and other likely targets of future small molecule drugs Overviews of the key features of a wide range of targets are provided on the summary view pages with detailed view pages providing more in depth information on the properties of a selected subset of targets As of January 2018 the Medicines for Malaria Venture is supporting a new extension to develop the Guide to Malaria Pharmacology The core GtoPdb continues to be supported by the British Pharmacological Society See also EditInternational Union of Basic and Clinical Pharmacology British Pharmacological Society Biological target British Journal of PharmacologyReferences Edit Armstrong JF Faccenda E Harding SD Pawson AJ Southan C Sharman JL Campo B Cavanagh DR Alexander SPH Davenport AP Spedding M Davies JA 8 January 2020 The IUPHAR BPS Guide to PHARMACOLOGY in 2020 extending immunopharmacology content and introducing the IUPHAR MMV Guide to MALARIA PHARMACOLOGY Nucleic Acids Research 48 D1 D1006 D1021 doi 10 1093 nar gkz951 PMC 7145572 PMID 31691834 Alexander S P Benson H E Davenport A Mathie A McGrath I J Pawson A J Peters J A Sharman J L Spedding M Harmar A J 2012 GuideToPharmacology org an update British Journal of Pharmacology 167 4 697 698 doi 10 1111 j 1476 5381 2012 02141 x PMC 3575771 PMID 23003568 Harding SD Faccenda E Southan C Maffia P Davies JA December 2018 A new guide to immunopharmacology Nature Reviews Immunology 18 12 729 doi 10 1038 s41577 018 0079 2 PMID 30327546 Alexander SP Mathie A Peters JA November 2011 Guide to Receptors and Channels GRAC 5th edition British Journal of Pharmacology 164 Suppl 1 Suppl 1 S1 324 doi 10 1111 j 1476 5381 2011 01649 1 x PMC 3315626 PMID 22040146 Alexander SP Kelly E Marrion NV Peters JA Faccenda E Harding SD Pawson AJ Sharman JL Southan C Buneman OP Cidlowski JA Christopoulos A Davenport AP Fabbro D Spedding M Striessnig J Davies JA CGTP Collaborators December 2017 THE CONCISE GUIDE TO PHARMACOLOGY 2017 18 Overview British Journal of Pharmacology 174 Suppl 1 Suppl Suppl 1 S1 S16 doi 10 1111 bph 13882 PMC 5650665 PMID 29055037 a href Template Cite journal html title Template Cite journal cite journal a first18 has generic name help External links EditIUPHAR BPS Guide to PHARMACOLOGY 2021 edition of the IUPHAR BPS Guide to PHARMACOLOGY published in BJP International Union of Basic and Clinical Pharmacology IUPHAR British Pharmacological Society BPS British Journal of Pharmacology Concise Guide to PHARMACOLOGY Wellcome Trust Medicines for Malaria Venture Retrieved from https en wikipedia org w index php title Guide to Pharmacology amp oldid 1123682485, wikipedia, wiki, book, books, library,
