The MGI resource was first published online in 1994[5] and is a collection of data, tools, and analyses created and tailored for use in the laboratory mouse, a widely used model organism. It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice.[6] The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which researchers can mine to advance their research. A dedicated community of mouse researchers, worldwide enhances and contributes to the knowledge as well. This is an indispensable tool for any researcher using the mouse as a model organism for their research, and for researchers interested in genes that share homology with the mouse genes. Various mouse research support resources including animal collections and free colony management software are also available at the MGI site.[7]
The Mouse Genome Database collects and curates comprehensive phenotype and functional annotations for mousegenes and alleles.[8] This is an NHGRI-funded project which contributes to the Mouse Genome Informatics database.
Mouse gene expression databaseedit
The Gene Expression Database is a community resource of mouse developmental expression information.[9]
Historyedit
The Mouse Genome Informatics homepage as it appeared in 1994
MGI evolved from a project funded by the National Center for Human Genome Research in 1989 to combine the databases of several Jackson Laboratory scientists and create a tool for visualizing data on the mouse genome.[10] The result of that project, led by Joseph H. Nadeau, Larry E. Mobraaten, and Janan T. Eppig, was called the "Encyclopedia of the Mouse Genome" and distributed via floppy disk semi-annually to around 300 scientists around the world.[10] In 1992, that group joined with the team responsible for developing the "Genomic Database for Mouse", led by Muriel T. Davisson and Thomas H. Roderick, to start the "Mouse Genome Informatics" project.[10] That project resulted in the first online release of the "Mouse Genome Database" in 1994.[10]
^"MGI-MGI Current Funding Support". jax.org. Retrieved 2 June 2015.
^Shaw D (May 2004). "Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype". Current Protocols in Bioinformatics. Chapter 1: Unit 1.7. doi:10.1002/0471250953.bi0107s05. ISBN0471250953. PMC5147750. PMID 18428715.
^Qi D, Blake JA, Kadin JA, Richardson JE, Ringwald M, Eppig JT, Bult CJ (8–11 August 2005). Data integration in the mouse genome informatics (MGI) database. Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE. pp. 37–8. doi:10.1109/CSBW.2005.48. ISBN0-7695-2442-7.
^"MGI-About the Mouse Genome Informatics database resource". jax.org. Retrieved 2 June 2015.
^ abLaw, M; Shaw, DR (2018). Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse. Methods in Molecular Biology. Vol. 1757. pp. 141–161. doi:10.1007/978-1-4939-7737-6_7. ISBN978-1-4939-7736-9. PMID 29761459.
^Mouse Nomenclature Home Page, retrieved 28 August 2016
^Ivica Letunic. . openhelix.com. Archived from the original on 26 December 2017. Retrieved 2 June 2015.
^Blake, Judith A.; Bult, Carol J.; Kadin, James A.; Richardson, Joel E.; Eppig, Janan T.; The Mouse Genome Database Group (Jan 2011). "The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics". Nucleic Acids Res. England. 39 (Database issue): D842-8. doi:10.1093/nar/gkq1008. PMC3013640. PMID 21051359.
^Finger, Jacqueline H; Smith Constance M; Hayamizu Terry F; McCright Ingeborg J; Eppig Janan T; Kadin James A; Richardson Joel E; Ringwald Martin (Jan 2011). "The mouse Gene Expression Database (GXD): 2011 update". Nucleic Acids Res. England. 39 (Database issue): D835-41. doi:10.1093/nar/gkq1132. PMC3013713. PMID 21062809.
^ abcdEppig JT, Richardson JE, Kadin JA, Ringwald M, Blake JA, Bult CJ (August 2015). "Mouse Genome Informatics (MGI): reflecting on 25 years". Mamm Genome. 26 (7–8): 272–84. doi:10.1007/s00335-015-9589-4. PMC4534491. PMID 26238262.
External linksedit
Bult, Carol J.; Blake, Judith A.; Smith, Cynthia L.; Kadin, James A.; Richardson, Joel E.; Mouse Genome Database Group (2019-01-08). "Mouse Genome Database (MGD) 2019". Nucleic Acids Research. 47 (D1): D801–D806. doi:10.1093/nar/gky1056. ISSN 1362-4962. PMC6323923. PMID 30407599.
Smith, Constance M.; Hayamizu, Terry F.; Finger, Jacqueline H.; Bello, Susan M.; McCright, Ingeborg J.; Xu, Jingxia; Baldarelli, Richard M.; Beal, Jonathan S.; Campbell, Jeffrey; Corbani, Lori E.; Frost, Pete J. (2019-01-08). "The mouse Gene Expression Database (GXD): 2019 update". Nucleic Acids Research. 47 (D1): D774–D779. doi:10.1093/nar/gky922. ISSN 1362-4962. PMC6324054. PMID 30335138.
mouse, genome, informatics, free, online, database, bioinformatics, resource, hosted, jackson, laboratory, with, funding, national, human, genome, research, institute, nhgri, national, cancer, institute, eunice, kennedy, shriver, national, institute, child, he. Mouse Genome Informatics MGI is a free online database and bioinformatics resource hosted by The Jackson Laboratory with funding by the National Human Genome Research Institute NHGRI the National Cancer Institute NCI and the Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD 1 MGI provides access to data on the genetics genomics and biology of the laboratory mouse to facilitate the study of human health and disease 2 3 The database integrates multiple projects with the two largest contributions coming from the Mouse Genome Database and Mouse Gene Expression Database GXD 4 As of 2018 update MGI contains data curated from over 230 000 publications 5 The MGI resource was first published online in 1994 5 and is a collection of data tools and analyses created and tailored for use in the laboratory mouse a widely used model organism It is the authoritative source of official names for mouse genes alleles and strains which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice 6 The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which researchers can mine to advance their research A dedicated community of mouse researchers worldwide enhances and contributes to the knowledge as well This is an indispensable tool for any researcher using the mouse as a model organism for their research and for researchers interested in genes that share homology with the mouse genes Various mouse research support resources including animal collections and free colony management software are also available at the MGI site 7 Contents 1 Mouse Genome Database 2 Mouse gene expression database 3 History 4 See also 5 References 6 External linksMouse Genome Database editThe Mouse Genome Database collects and curates comprehensive phenotype and functional annotations for mouse genes and alleles 8 This is an NHGRI funded project which contributes to the Mouse Genome Informatics database Mouse gene expression database editThe Gene Expression Database is a community resource of mouse developmental expression information 9 History edit nbsp The Mouse Genome Informatics homepage as it appeared in 1994MGI evolved from a project funded by the National Center for Human Genome Research in 1989 to combine the databases of several Jackson Laboratory scientists and create a tool for visualizing data on the mouse genome 10 The result of that project led by Joseph H Nadeau Larry E Mobraaten and Janan T Eppig was called the Encyclopedia of the Mouse Genome and distributed via floppy disk semi annually to around 300 scientists around the world 10 In 1992 that group joined with the team responsible for developing the Genomic Database for Mouse led by Muriel T Davisson and Thomas H Roderick to start the Mouse Genome Informatics project 10 That project resulted in the first online release of the Mouse Genome Database in 1994 10 See also editFlyBase Rat Genome Database Saccharomyces Genome Database WormBase Xenbase Zebrafish Information NetworkReferences edit MGI MGI Current Funding Support jax org Retrieved 2 June 2015 Shaw D May 2004 Searching the Mouse Genome Informatics MGI resources for information on mouse biology from genotype to phenotype Current Protocols in Bioinformatics Chapter 1 Unit 1 7 doi 10 1002 0471250953 bi0107s05 ISBN 0471250953 PMC 5147750 PMID 18428715 Qi D Blake JA Kadin JA Richardson JE Ringwald M Eppig JT Bult CJ 8 11 August 2005 Data integration in the mouse genome informatics MGI database Computational Systems Bioinformatics Conference 2005 Workshops and Poster Abstracts IEEE pp 37 8 doi 10 1109 CSBW 2005 48 ISBN 0 7695 2442 7 MGI About the Mouse Genome Informatics database resource jax org Retrieved 2 June 2015 a b Law M Shaw DR 2018 Mouse Genome Informatics MGI Is the International Resource for Information on the Laboratory Mouse Methods in Molecular Biology Vol 1757 pp 141 161 doi 10 1007 978 1 4939 7737 6 7 ISBN 978 1 4939 7736 9 PMID 29761459 Mouse Nomenclature Home Page retrieved 28 August 2016 Ivica Letunic OpenHelix Mouse Genome Informatics MGI openhelix com Archived from the original on 26 December 2017 Retrieved 2 June 2015 Blake Judith A Bult Carol J Kadin James A Richardson Joel E Eppig Janan T The Mouse Genome Database Group Jan 2011 The Mouse Genome Database MGD premier model organism resource for mammalian genomics and genetics Nucleic Acids Res England 39 Database issue D842 8 doi 10 1093 nar gkq1008 PMC 3013640 PMID 21051359 Finger Jacqueline H Smith Constance M Hayamizu Terry F McCright Ingeborg J Eppig Janan T Kadin James A Richardson Joel E Ringwald Martin Jan 2011 The mouse Gene Expression Database GXD 2011 update Nucleic Acids Res England 39 Database issue D835 41 doi 10 1093 nar gkq1132 PMC 3013713 PMID 21062809 a b c d Eppig JT Richardson JE Kadin JA Ringwald M Blake JA Bult CJ August 2015 Mouse Genome Informatics MGI reflecting on 25 years Mamm Genome 26 7 8 272 84 doi 10 1007 s00335 015 9589 4 PMC 4534491 PMID 26238262 External links editBult Carol J Blake Judith A Smith Cynthia L Kadin James A Richardson Joel E Mouse Genome Database Group 2019 01 08 Mouse Genome Database MGD 2019 Nucleic Acids Research 47 D1 D801 D806 doi 10 1093 nar gky1056 ISSN 1362 4962 PMC 6323923 PMID 30407599 nbsp Wikidata has the property nbsp Mouse Genome Informatics ID P671 see uses Mouse Genome Informatics home page Smith Constance M Hayamizu Terry F Finger Jacqueline H Bello Susan M McCright Ingeborg J Xu Jingxia Baldarelli Richard M Beal Jonathan S Campbell Jeffrey Corbani Lori E Frost Pete J 2019 01 08 The mouse Gene Expression Database GXD 2019 update Nucleic Acids Research 47 D1 D774 D779 doi 10 1093 nar gky922 ISSN 1362 4962 PMC 6324054 PMID 30335138 Mouse Genome Informatics Publications Tutorial from the Open Door workshop permanent dead link Gene eXpression Database GXD Retrieved from https en wikipedia org w index php title Mouse Genome Informatics amp oldid 1126496724, wikipedia, wiki, book, books, library,
