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Tourette syndrome

January 01, 1970

"Tourette" redirects here. For other uses, see Tourette (disambiguation).

Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence. It is characterized by multiple movement (motor) tics and at least one vocal (phonic) tic. Common tics are blinking, coughing, throat clearing, sniffing, and facial movements. These are typically preceded by an unwanted urge or sensation in the affected muscles known as a premonitory urge, can sometimes be suppressed temporarily, and characteristically change in location, strength, and frequency. Tourette's is at the more severe end of a spectrum of tic disorders. The tics often go unnoticed by casual observers.

Tourette syndrome
Other namesTourette's syndrome, Tourette's disorder, Gilles de la Tourette syndrome (GTS), combined vocal and multiple motor tic disorder [de la Tourette]
Georges Gilles de la Tourette (1857–1904),
namesake of Tourette syndrome
SpecialtyPediatrics, neurology, psychiatry[1]
SymptomsTics[2]
Usual onsetTypically in childhood[2]
DurationLong term[3]
CausesGenetic with environmental influence[3]
Diagnostic methodBased on history and symptoms[2]
MedicationUsually none, occasionally neuroleptics and noradrenergics[2]
Prognosis80% will experience improvement to disappearance of tics beginning in late teens[3]
FrequencyAbout 1% of children and adolescents[4]
Between 0.3% and 1.0% of general population[5]

Tourette's was once regarded as a rare and bizarre syndrome and has popularly been associated with coprolalia (the utterance of obscene words or socially inappropriate and derogatory remarks). It is no longer considered rare; about 1% of school-age children and adolescents are estimated to have Tourette's,[2] though coprolalia occurs only in a minority. There are no specific tests for diagnosing Tourette's; it is not always correctly identified, because most cases are mild, and the severity of tics decreases for most children as they pass through adolescence. Therefore, many go undiagnosed or may never seek medical attention. Extreme Tourette's in adulthood, though sensationalized in the media, is rare, but for a small minority, severely debilitating tics can persist into adulthood. Tourette's does not affect intelligence or life expectancy.

There is no cure for Tourette's and no single most effective medication. In most cases, medication for tics is not necessary, and behavioral therapies are the first-line treatment. Education is an important part of any treatment plan, and explanation alone often provides sufficient reassurance that no other treatment is necessary.[2] Other conditions, such as attention deficit hyperactivity disorder (ADHD) and obsessive–compulsive disorder (OCD), are more likely to be present among those who are referred to specialty clinics than they are among the broader population of persons with Tourette's. These co-occurring conditions often cause more impairment to the individual than the tics; hence it is important to correctly distinguish co-occurring conditions and treat them.

Tourette syndrome was named by French neurologist Jean-Martin Charcot for his intern, Georges Gilles de la Tourette, who published in 1885 an account of nine patients with a "convulsive tic disorder". While the exact cause is unknown, it is believed to involve a combination of genetic and environmental factors. The mechanism appears to involve dysfunction in neural circuits between the basal ganglia and related structures in the brain.

Classification

Most published research on Tourette syndrome originates in the United States; in international TS research and clinical practice, the Diagnostic and Statistical Manual of Mental Disorders (DSM) is preferred over the World Health Organization (WHO) classification,[5][7][8] which is criticized in the 2021 European Clinical Guidelines.[1]

In the fifth version of the DSM (DSM-5), published in 2013, Tourette syndrome is classified as a motor disorder (a disorder of the nervous system that causes abnormal and involuntary movements). It is listed in the neurodevelopmental disorder category.[9] Tourette's is at the more severe end of the spectrum of tic disorders; its diagnosis requires multiple motor tics and at least one vocal tic to be present for more than a year. Tics are sudden, repetitive, nonrhythmic movements that involve discrete muscle groups,[10] while vocal (phonic) tics involve laryngeal, pharyngeal, oral, nasal or respiratory muscles to produce sounds.[11][12] The tics must not be explained by other medical conditions or substance use.[13]

Other tic disorders include persistent (chronic) motor or vocal tics, in which one type of tic (motor or vocal, but not both) has been present for more than a year; and provisional tic disorder, in which motor or vocal tics have been present for less than one year.[14][15] The fifth edition of the DSM replaced what had been called transient tic disorder with provisional tic disorder, recognizing that "transient" can only be defined in retrospect.[7][16][17] Some experts believe that TS and persistent (chronic) motor or vocal tic disorder should be considered the same condition, because vocal tics are also motor tics in the sense that they are muscular contractions of nasal or respiratory muscles.[5][6][15]

Tourette syndrome is defined only slightly differently by the WHO;[4][8] in its ICD-11, the International Statistical Classification of Diseases and Related Health Problems, Tourette syndrome is classified as a disease of the nervous system and a neurodevelopmental disorder,[18][19] and only one motor tic and one or more vocal tics are required for diagnosis.[20] Older versions of the ICD called it "combined vocal and multiple motor tic disorder [de la Tourette]".[21]

Genetic studies indicate that tic disorders cover a spectrum that is not recognized by the clear-cut distinctions in the current diagnostic framework.[13] Since 2008, studies have suggested that Tourette's is not a unitary condition with a distinct mechanism, as described in the existing classification systems. Instead, the studies suggest that subtypes should be recognized to distinguish "pure TS" from TS that is accompanied by attention deficit hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD) or other disorders, similar to the way that subtypes have been established for other conditions, such as type 1 and type 2 diabetes.[4][13][20] Elucidation of these subtypes awaits fuller understanding of the genetic and other causes of tic disorders.[7]

Characteristics

Tics

Examples of tics

Tics are movements or sounds that take place "intermittently and unpredictably out of a background of normal motor activity",[22] having the appearance of "normal behaviors gone wrong".[23] The tics associated with Tourette's wax and wane; they change in number, frequency, severity, anatomical location, and complexity;[5] each person experiences a unique pattern of fluctuation in their severity and frequency. Tics may also occur in "bouts of bouts", which also vary among people.[24] The variation in tic severity may occur over hours, days, or weeks.[14] Tics may increase when someone is experiencing stress, fatigue, anxiety, or illness,[13][25] or when engaged in relaxing activities like watching TV. They sometimes decrease when an individual is engrossed in or focused on an activity like playing a musical instrument.[13][26]

In contrast to the abnormal movements associated with other movement disorders, the tics of Tourette's are nonrhythmic, often preceded by an unwanted urge, and temporarily suppressible.[24][27] Over time, about 90% of individuals with Tourette's feel an urge preceding the tic,[14] similar to the urge to sneeze or scratch an itch. The urges and sensations that precede the expression of a tic are referred to as premonitory sensory phenomena or premonitory urges. People describe the urge to express the tic as a buildup of tension, pressure, or energy[28][29] which they ultimately choose consciously to release, as if they "had to do it"[30] to relieve the sensation[28] or until it feels "just right".[30][31] The urge may cause a distressing sensation in the part of the body associated with the resulting tic; the tic is a response that relieves the urge in the anatomical location of the tic.[2][24] Examples of this urge are the feeling of having something in one's throat, leading to a tic to clear one's throat, or a localized discomfort in the shoulders leading to shrugging the shoulders. The actual tic may be felt as relieving this tension or sensation, similar to scratching an itch or blinking to relieve an uncomfortable feeling in the eye.[2][22] Some people with Tourette's may not be aware of the premonitory urge associated with tics. Children may be less aware of it than are adults,[14] but their awareness tends to increase with maturity;[22] by the age of ten, most children recognize the premonitory urge.[26]

Premonitory urges which precede the tic make suppression of the impending tic possible.[24] Because of the urges that precede them, tics are described as semi-voluntary or "unvoluntary",[2][22] rather than specifically involuntary; they may be experienced as a voluntary, suppressible response to the unwanted premonitory urge.[24][26] The ability to suppress tics varies among individuals, and may be more developed in adults than children.[32] People with tics are sometimes able to suppress them for limited periods of time, but doing so often results in tension or mental exhaustion.[2][33] People with Tourette's may seek a secluded spot to release the suppressed urge, or there may be a marked increase in tics after a period of suppression at school or work.[14][23] Children may suppress tics while in the doctor's office, so they may need to be observed when not aware of being watched.[34]

Complex tics related to speech include coprolalia, echolalia and palilalia. Coprolalia is the spontaneous utterance of socially objectionable or taboo words or phrases. Although it is the most publicized symptom of Tourette's, only about 10% of people with Tourette's exhibit it, and it is not required for a diagnosis.[2][35] Echolalia (repeating the words of others) and palilalia (repeating one's own words) occur in a minority of cases.[36] Complex motor tics include copropraxia (obscene or forbidden gestures, or inappropriate touching), echopraxia (repetition or imitation of another person's actions) and palipraxia (repeating one's own movements).[32]

Onset and progression

There is no typical case of Tourette syndrome,[37] but the age of onset and the severity of symptoms follow a fairly reliable course. Although onset may occur anytime before eighteen years, the typical age of onset of tics is from five to seven, and is usually before adolescence.[2] A 1998 study from the Yale Child Study Center showed that tic severity increased with age until it reached its highest point between ages eight and twelve.[38] Severity declines steadily for most children as they pass through adolescence, when half to two-thirds of children see a dramatic decrease in tics.[39]

In people with TS, the first tics to appear usually affect the head, face, and shoulders, and include blinking, facial movements, sniffing and throat clearing.[14] Vocal tics often appear months or years after motor tics but can appear first.[7][15] Among people who experience more severe tics, complex tics may develop, including "arm straightening, touching, tapping, jumping, hopping and twirling".[14] There are different movements in contrasting disorders (for example, the autism spectrum disorders), such as self-stimulation and stereotypies.[40]

The severity of symptoms varies widely among people with Tourette's, and many cases may be undetected.[2][4][15][36] Most cases are mild and almost unnoticeable;[41][42] many people with TS may not realize they have tics. Because tics are more commonly expressed in private, Tourette syndrome may go unrecognized,[43] and casual observers might not notice tics.[35][44][45] Most studies of TS involve males, who have a higher prevalence of TS than females, and gender-based differences are not well studied; a 2021 review suggested that the characteristics and progression for females, particularly in adulthood, may differ and better studies are needed.[46]

Most adults with TS have mild symptoms and do not seek medical attention.[2] While tics subside for the majority after adolescence, some of the "most severe and debilitating forms of tic disorder are encountered" in adults.[47] In some cases, what appear to be adult-onset tics can be childhood tics re-surfacing.[47]

Co-occurring conditions

 
André Malraux (center) was a French Minister of Culture, author and adventurer who may have had Tourette syndrome.[48][49][50]

Because people with milder symptoms are unlikely to be referred to specialty clinics, studies of Tourette's have an inherent bias towards more severe cases.[51][52] When symptoms are severe enough to warrant referral to clinics, ADHD and OCD are often also found.[2] In specialty clinics, 30% of those with TS also have mood or anxiety disorders or disruptive behaviors.[14][53] In the absence of ADHD, tic disorders do not appear to be associated with disruptive behavior or functional impairment,[54] while impairment in school, family, or peer relations is greater in those who have more comorbid conditions.[23][55] When ADHD is present along with tics, the occurrence of conduct disorder and oppositional defiant disorder increases.[14] Aggressive behaviors and angry outbursts in people with TS are not well understood; they are not associated with severe tics, but are connected with the presence of ADHD.[56] ADHD may also contribute to higher rates of anxiety, and aggression and anger control problems are more likely when both OCD and ADHD co-occur with Tourette's.[47]

Compulsions that resemble tics are present in some individuals with OCD; "tic-related OCD" is hypothesized to be a subgroup of OCD, distinguished from non-tic related OCD by the type and nature of obsessions and compulsions.[57] Compared to the more typical compulsions of OCD without tics that relate to contamination, tic-related OCD presents with more "counting, aggressive thoughts, symmetry and touching" compulsions.[14] Compulsions associated with OCD without tics are usually related to obsessions and anxiety, while those in tic-related OCD are more likely to be a response to a premonitory urge.[14][58] There are increased rates of anxiety and depression in those adults with TS who also have OCD.[47]

Among individuals with TS studied in clinics, between 2.9% and 20% had autism spectrum disorders,[59] but one study indicates that a high association of autism and TS may be partly due to difficulties distinguishing between tics and tic-like behaviors or OCD symptoms seen in people with autism.[60]

Not all people with Tourette's have ADHD or OCD or other comorbid conditions, and estimates of the rate of pure TS or TS-only vary from 15% to 57%;[a] in clinical populations, a high percentage of those under care do have ADHD.[31][61] Children and adolescents with pure TS are not significantly different from their peers without TS on ratings of aggressive behaviors or conduct disorders, or on measures of social adaptation.[4] Similarly, adults with pure TS do not appear to have the social difficulties present in those with TS plus ADHD.[4]

Among those with an older age of onset, more substance abuse and mood disorders are found, and there may be self-injurious tics. Adults who have severe, often treatment-resistant tics are more likely to also have mood disorders and OCD.[47] Coprolalia is more likely in people with severe tics plus multiple comorbid conditions.[32]

Neuropsychological function

There are no major impairments in neuropsychological function among people with Tourette's, but conditions that occur along with tics can cause variation in neurocognitive function. A better understanding of comorbid conditions is needed to untangle any neuropsychological differences between TS-only individuals and those with comorbid conditions.[55]

Only slight impairments are found in intellectual ability, attentional ability, and nonverbal memory—but ADHD, other comorbid disorders, or tic severity could account for these differences. In contrast with earlier findings, visual motor integration and visuoconstructive skills are not found to be impaired, while comorbid conditions may have a small effect on motor skills. Comorbid conditions and severity of tics may account for variable results in verbal fluency, which can be slightly impaired. There might be slight impairment in social cognition, but not in the ability to plan or make decisions.[55] Children with TS-only do not show cognitive deficits. They are faster than average for their age on timed tests of motor coordination, and constant tic suppression may lead to an advantage in switching between tasks because of increased inhibitory control.[4][63]

Learning disabilities may be present, but whether they are due to tics or comorbid conditions is controversial; older studies that reported higher rates of learning disability did not control well for the presence of comorbid conditions.[64] There are often difficulties with handwriting, and disabilities in written expression and math are reported in those with TS plus other conditions.[64]

Causes

Main article: Causes and origins of Tourette syndrome

The exact cause of Tourette's is unknown, but it is well established that both genetic and environmental factors are involved.[13][14][65] Genetic epidemiology studies have shown that Tourette's is highly heritable,[66] and 10 to 100 times more likely to be found among close family members than in the general population.[67] The exact mode of inheritance is not known; no single gene has been identified,[5] and hundreds of genes are likely involved.[51][66][67] Genome-wide association studies were published in 2013[2] and 2015[14] in which no finding reached a threshold for significance;[2] a 2019 meta-analysis found only a single genome-wide significant locus on chromosome 13, but that result was not found in broader samples.[68] Twin studies show that 50 to 77% of identical twins share a TS diagnosis, while only 10 to 23% of fraternal twins do.[13] But not everyone who inherits the genetic vulnerability will show symptoms.[69][70] A few rare highly penetrant genetic mutations have been found that explain only a small number of cases in single families (the SLITRK1, HDC, and CNTNAP2 genes).[71]

Psychosocial or other non-genetic factors—while not causing Tourette's—can affect the severity of TS in vulnerable individuals and influence the expression of the inherited genes.[4][37][65][67] Pre-natal and peri-natal events increase the risk that a tic disorder or comorbid OCD will be expressed in those with the genetic vulnerability. These include paternal age; forceps delivery; stress or severe nausea during pregnancy; and use of tobacco, caffeine, alcohol,[4][20] and cannabis during pregnancy.[2] Babies who are born premature with low birthweight, or who have low Apgar scores, are also at increased risk; in premature twins, the lower birthweight twin is more likely to develop TS.[4]

Autoimmune processes may affect the onset of tics or exacerbate them. Both OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post-streptococcal autoimmune process.[72] Its potential effect is described by the controversial[72] hypothesis called PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections), which proposes five criteria for diagnosis in children.[73][74] PANDAS and the newer pediatric acute-onset neuropsychiatric syndrome (PANS) hypotheses are the focus of clinical and laboratory research, but remain unproven.[73] There is also a broader hypothesis that links immune-system abnormalities and immune dysregulation with TS.[14][72]

Some forms of OCD may be genetically linked to Tourette's,[31] although the genetic factors in OCD with and without tics may differ.[13] The genetic relationship of ADHD to Tourette syndrome, however, has not been fully established.[53][63][75] A genetic link between autism and Tourette's has not been established as of 2017.[47]

Mechanism

 
The basal ganglia and thalamus are implicated in Tourette syndrome.

The exact mechanism affecting the inherited vulnerability to Tourette's is not well established.[13] Tics are believed to result from dysfunction in cortical and subcortical brain regions: the thalamus, basal ganglia and frontal cortex.[76] Neuroanatomic models suggest failures in circuits connecting the brain's cortex and subcortex;[37] imaging techniques implicate the frontal cortex and basal ganglia.[51] In the 2010s, neuroimaging and postmortem brain studies, as well as animal and genetic studies,[55][77] made progress towards better understanding the neurobiological mechanisms leading to Tourette's.[55] These studies support the basal ganglia model, in which neurons in the striatum are activated and inhibit outputs from the basal ganglia.[56]

Cortico-striato-thalamo-cortical (CSTC) circuits, or neural pathways, provide inputs to the basal ganglia from the cortex. These circuits connect the basal ganglia with other areas of the brain to transfer information that regulates planning and control of movements, behavior, decision-making, and learning.[55] Behavior is regulated by cross-connections that "allow the integration of information" from these circuits.[55] Involuntary movements may result from impairments in these CSTC circuits,[55] including the sensorimotor, limbic, language and decision making pathways. Abnormalities in these circuits may be responsible for tics and premonitory urges.[78]

The caudate nuclei may be smaller in subjects with tics compared to those without tics, supporting the hypothesis of pathology in CSTC circuits in Tourette's.[55] The ability to suppress tics depends on brain circuits that "regulate response inhibition and cognitive control of motor behavior".[77] Children with TS are found to have a larger prefrontal cortex, which may be the result of an adaptation to help regulate tics.[77] It is likely that tics decrease with age as the capacity of the frontal cortex increases.[77] Cortico-basal ganglia (CBG) circuits may also be impaired, contributing to "sensory, limbic and executive" features.[14] The release of dopamine in the basal ganglia is higher in people with Tourette's, implicating biochemical changes from "overactive and dysregulated dopaminergic transmissions".[65]

Histamine and the H3 receptor may play a role in the alterations of neural circuitry.[14][79][80][81] A reduced level of histamine in the H3 receptor may result in an increase in other neurotransmitters, causing tics.[82] Postmortem studies have also implicated "dysregulation of neuroinflammatory processes".[13]

Diagnosis

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5),[b] Tourette's may be diagnosed when a person exhibits both multiple motor tics and one or more vocal tics over a period of one year. The motor and vocal tics need not be concurrent. The onset must have occurred before the age of 18 and cannot be attributed to the effects of another condition or substance (such as cocaine).[9] Hence, other medical conditions that include tics or tic-like movements—for example, autism or other causes of tics—must be ruled out.[84]

Patients referred for a tic disorder are assessed based on their family history of tics, vulnerability to ADHD, obsessive–compulsive symptoms, and a number of other chronic medical, psychiatric and neurological conditions.[85][86] In individuals with a typical onset and a family history of tics or OCD, a basic physical and neurological examination may be sufficient.[87] There are no specific medical or screening tests that can be used to diagnose Tourette's;[31] the diagnosis is usually made based on observation of the individual's symptoms and family history,[35] and after ruling out secondary causes of tic disorders (tourettism).[88]

Delayed diagnosis often occurs because professionals mistakenly believe that TS is rare, always involves coprolalia, or must be severely impairing.[89] The DSM has recognized since 2000 that many individuals with Tourette's do not have significant impairment;[7][84][90] diagnosis does not require the presence of coprolalia or a comorbid condition, such as ADHD or OCD.[35][89] Tourette's may be misdiagnosed because of the wide expression of severity, ranging from mild (in the majority of cases) or moderate, to severe (the rare but more widely recognized and publicized cases).[38] About 20% of people with Tourette syndrome do not realize that they have tics.[37]

Tics that appear early in the course of TS are often confused with allergies, asthma, vision problems, and other conditions. Pediatricians, allergists and ophthalmologists are among the first to see or identify a child as having tics,[5][36][91] although the majority of tics are first identified by the child's parents.[89] Coughing, blinking, and tics that mimic unrelated conditions such as asthma are commonly misdiagnosed.[35] In the UK, there is an average delay of three years between symptom onset and diagnosis.[4]

Differential diagnosis

Main screening and assessment tools[92][93]

Tics that may appear to mimic those of Tourette's—but are associated with disorders other than Tourette's—are known as tourettism[94] and are ruled out in the differential diagnosis for Tourette syndrome.[87] The abnormal movements associated with choreas, dystonias, myoclonus, and dyskinesias are distinct from the tics of Tourette's in that they are more rhythmic, not suppressible, and not preceded by an unwanted urge.[24][27] Developmental and autism spectrum disorders may manifest tics, other stereotyped movements,[95] and stereotypic movement disorder.[96][97] The stereotyped movements associated with autism typically have an earlier age of onset; are more symmetrical, rhythmical and bilateral; and involve the extremities (for example, flapping the hands).[40]

If another condition might better explain the tics, tests may be done; for example, if there is diagnostic confusion between tics and seizure activity, an EEG may be ordered. An MRI can rule out brain abnormalities, but such brain imaging studies are not usually warranted.[85] Measuring thyroid-stimulating hormone blood levels can rule out hypothyroidism, which can be a cause of tics. If there is a family history of liver disease, serum copper and ceruloplasmin levels can rule out Wilson's disease.[87] The typical age of onset of TS is before adolescence.[2] In teenagers and adults with an abrupt onset of tics and other behavioral symptoms, a urine drug screen for stimulants might be requested.[87]

Increasing episodes of tic-like behavior among teenagers (predominantly adolescent girls) were reported in several countries during the COVID-19 pandemic.[20][91] Researchers linked their occurrence to followers of certain TikTok or YouTube artists.[5][91] Described in 2006 as psychogenic,[96] abrupt-onset movements resembling tics are referred to as a functional movement disorder[98] or functional tic-like movements.[91][d] Functional tic-like movements can be difficult to distinguish from tics that have an organic (rather than psychological) cause.[98][100] They may occur alone or co-exist in individuals with tic disorders.[98][102] These tics are inconsistent with the classic tics of TS in several ways:[103] the premonitory urge (present in 90% of those with tics disorders[99]) is absent in functional tic-like movements; the suppressibility seen in tic disorders is lacking;[98][99][100][101] there is no family or childhood history of tics and there is a female predominance in functional tics,[91] with a later-than-typical age of first presentation;[98][99][100] onset is more abrupt than typical with movements that are more suggestible;[99] and there is less co-occurring OCD or ADHD and more co-occurring disorders.[100] Functional tics are "not fully stereotypical",[101] do not respond to medications, do not demonstrate the classic waxing and waning pattern of Tourettic tics,[98] and do not progress in the typical fashion, in which tics often first appear in the face and gradually move to limbs.[100]

Other conditions that may manifest tics include Sydenham's chorea; idiopathic dystonia; and genetic conditions such as Huntington's disease, neuroacanthocytosis, pantothenate kinase-associated neurodegeneration, Duchenne muscular dystrophy, Wilson's disease, and tuberous sclerosis. Other possibilities include chromosomal disorders such as Down syndrome, Klinefelter syndrome, XYY syndrome and fragile X syndrome. Acquired causes of tics include drug-induced tics, head trauma, encephalitis, stroke, and carbon monoxide poisoning.[87][94] The extreme self-injurious behaviors of Lesch-Nyhan syndrome may be confused with Tourette syndrome or stereotypies, but self-injury is rare in TS even in cases of violent tics.[40] Most of these conditions are rarer than tic disorders and a thorough history and examination may be enough to rule them out without medical or screening tests.[2][37][94]

Screening for other conditions

Although not all those with Tourette's have comorbid conditions, most presenting for clinical care exhibit symptoms of other conditions along with their tics.[63] ADHD and OCD are the most common, but autism spectrum disorders or anxiety, mood, personality, oppositional defiant, and conduct disorders may also be present.[11] Learning disabilities and sleep disorders may be present;[35] higher rates of sleep disturbance and migraine than in the general population are reported.[104][105] A thorough evaluation for comorbidity is called for when symptoms and impairment warrant,[86][87] and careful assessment of people with TS includes comprehensive screening for these conditions.[11][67]

Comorbid conditions such as OCD and ADHD can be more impairing than tics, and cause greater impact on overall functioning.[6][37] Disruptive behaviors, impaired functioning, or cognitive impairment in individuals with comorbid Tourette's and ADHD may be accounted for by the ADHD, highlighting the importance of identifying comorbid conditions.[14][31][35][106] Children and adolescents with TS who have learning difficulties are candidates for psychoeducational testing, particularly if the child also has ADHD.[85][86]

Management

Main article: Management of Tourette syndrome

There is no cure for Tourette's.[107] There is no single most effective medication,[2] and no one medication effectively treats all symptoms. Most medications prescribed for tics have not been approved for that use, and no medication is without the risk of significant adverse effects.[6][35][108] Treatment is focused on identifying the most troubling or impairing symptoms and helping the individual manage them.[35] Because comorbid conditions are often a larger source of impairment than tics,[20] they are a priority in treatment.[109] The management of Tourette's is individualized and involves shared decision-making between the clinician, patient, family and caregivers.[109][110] Practice guidelines for the treatment of tics were published by the American Academy of Neurology in 2019.[109]

Education, reassurance and psychobehavioral therapy are often sufficient for the majority of cases.[2][35][111] In particular, psychoeducation targeting the patient and their family and surrounding community is a key management strategy.[112][113] Watchful waiting "is an acceptable approach" for those who are not functionally impaired.[109] Symptom management may include behavioral, psychological and pharmacological therapies. Pharmacological intervention is reserved for more severe symptoms, while psychotherapy or cognitive behavioral therapy (CBT) may ameliorate depression and social isolation, and improve family support.[35] The decision to use behavioral or pharmacological treatment is "usually made after the educational and supportive interventions have been in place for a period of months, and it is clear that the tic symptoms are persistently severe and are themselves a source of impairment in terms of self-esteem, relationships with the family or peers, or school performance".[93]

Psychoeducation and social support

Further information: Management of Tourette syndrome § Psychoeducation and social support

Knowledge, education and understanding are uppermost in management plans for tic disorders,[35] and psychoeducation is the first step.[114][115] A child's parents are typically the first to notice their tics;[89] they may feel worried, imagine that they are somehow responsible, or feel burdened by misinformation about Tourette's.[114] Effectively educating parents about the diagnosis and providing social support can ease their anxiety. This support can also lower the chance that their child will be unnecessarily medicated[116] or experience an exacerbation of tics due to their parents' emotional state.[11]

People with Tourette's may suffer socially if their tics are viewed as "bizarre". If a child has disabling tics, or tics that interfere with social or academic functioning, supportive psychotherapy or school accommodations can be helpful.[88] Even children with milder tics may be angry, depressed or have low self-esteem as a result of increased teasing, bullying, rejection by peers or social stigmatization, and this can lead to social withdrawal. Some children feel empowered by presenting a peer awareness program to their classmates.[67][110][117] It can be helpful to educate teachers and school staff about typical tics, how they fluctuate during the day, how they impact the child, and how to distinguish tics from naughty behavior. By learning to identify tics, adults can refrain from asking or expecting a child to stop ticcing,[33][117] because "tic suppression can be exhausting, unpleasant, and attention-demanding and can result in a subsequent rebound bout of tics".[33]

Adults with TS may withdraw socially to avoid stigmatization and discrimination because of their tics.[118] Depending on their country's healthcare system, they may receive social services or help from support groups.[119]

Behavioral

Further information: Management of Tourette syndrome § Behavioral

Behavioral therapies using habit reversal training (HRT) and exposure and response prevention (ERP) are first-line interventions in the management of Tourette syndrome,[20][115] and have been shown to be effective.[13] Because tics are somewhat suppressible, when people with TS are aware of the premonitory urge that precedes a tic, they can be trained to develop a response to the urge that competes with the tic.[14][120] Comprehensive behavioral intervention for tics (CBIT) is based on HRT, the best researched behavioral therapy for tics.[120] TS experts debate whether increasing a child's awareness of tics with HRT/CBIT (as opposed to ignoring tics) can lead to more tics later in life.[120]

When disruptive behaviors related to comorbid conditions exist, anger control training and parent management training can be effective.[4][121][122] CBT is a useful treatment when OCD is present.[14] Relaxation techniques, such as exercise, yoga and meditation may be useful in relieving the stress that can aggravate tics. Beyond HRT, the majority of behavioral interventions for Tourette's (for example, relaxation training and biofeedback) have not been systematically evaluated and are not empirically supported.[123]

Medication

Further information: Management of Tourette syndrome § Medication
 
Clonidine is one of the medications typically tried first when medication is needed for Tourette's.[124]

Children with tics typically present when their tics are most severe, but because the condition waxes and wanes, medication is not started immediately or changed often.[37] Tics may subside with education, reassurance and a supportive environment.[2][67] When medication is used, the goal is not to eliminate symptoms. Instead, the lowest dose that manages symptoms without adverse effects is used, because adverse effects may be more disturbing than the symptoms being treated with medication.[37]

The classes of medication with proven efficacy in treating tics—typical and atypical neuroleptics—can have long-term and short-term adverse effects.[67] Some antihypertensive agents are also used to treat tics; studies show variable efficacy but a lower side effect profile than the neuroleptics.[13][124] The antihypertensives clonidine and guanfacine are typically tried first in children; they can also help with ADHD symptoms,[67][124] but there is less evidence that they are effective for adults.[2] The neuroleptics risperidone and aripiprazole are tried when antihypertensives are not effective,[6][67] and are generally tried first for adults.[2] Because of lower side effects, aripiprazole is preferred over other antipsychotics.[125] The most effective medication for tics is haloperidol, but it has a higher risk of side effects.[67] Methylphenidate can be used to treat ADHD that co-occurs with tics, and can be used in combination with clonidine.[14][67] Selective serotonin reuptake inhibitors are used to manage anxiety and OCD.[14]

Other

Further information: Management of Tourette syndrome § Other

Complementary and alternative medicine approaches, such as dietary modification, neurofeedback and allergy testing and control have popular appeal, but they have no proven benefit in the management of Tourette syndrome.[126][127] Despite this lack of evidence, up to two-thirds of parents, caregivers and individuals with TS use dietary approaches and alternative treatments and do not always inform their physicians.[25][110]

There is low confidence that tics are reduced with tetrahydrocannabinol,[6] and insufficient evidence for other cannabis-based medications in the treatment of Tourette's.[109][128] There is no good evidence supporting the use of acupuncture or transcranial magnetic stimulation; neither is there evidence supporting intravenous immunoglobulin, plasma exchange, or antibiotics for the treatment of PANDAS.[4]

Deep brain stimulation (DBS) has become a valid option for individuals with severe symptoms that do not respond to conventional therapy and management,[65] although it is an experimental treatment.[129] Selecting candidates who may benefit from DBS is challenging, and the appropriate lower age range for surgery is unclear;[11] it is potentially useful in less than 3% of individuals.[1] The ideal brain location to target has not been identified as of 2019.[109][130]

Pregnancy

A quarter of women report that their tics increase before menstruation; however, studies have not shown consistent evidence of a change in frequency or severity of tics related to pregnancy[131][132] or hormonal levels.[133] Overall, symptoms in women respond better to haloperidol than they do for men.[131]

Most women find they can withdraw from medication during pregnancy without much trouble.[134] When needed, medications are used at the lowest doses possible.[133] During pregnancy, neuroleptic medications are avoided when possible because of the risk of pregnancy complications.[132] When needed, olanzapine, risperidone and quetiapine are most often used as they have not been shown to cause fetal abnormalities.[132] One report found that haloperidol could be used during pregnancy,[134] to minimize the side effects in the mother, including low blood pressure, and anticholinergic effects,[135] although it may cross the placenta.[132]

If severe tics might interfere with administration of local anesthesia, other anesthesia options are considered.[132] Neuroleptics in low doses may not affect the breastfed infant, but most medications are avoided.[132] Clonidine and amphetamines may be present in breast milk.[133]

Prognosis

 
Tim Howard, described in 2019 by a staff writer for the Los Angeles Times as the "greatest goalkeeper in U.S. soccer history",[136] attributes his success in the sport to his Tourette's.[137]

Tourette syndrome is a spectrum disorder—its severity ranges from mild to severe.[88] Symptoms typically subside as children pass through adolescence.[65] In a group of ten children at the average age of highest tic severity (around ten or eleven), almost four will see complete remission by adulthood. Another four will have minimal or mild tics in adulthood, but not complete remission. The remaining two will have moderate or severe tics as adults, but only rarely will their symptoms in adulthood be more severe than in childhood.[39]

Regardless of symptom severity, individuals with Tourette's have a normal life span.[138] Symptoms may be lifelong and chronic for some, but the condition is not degenerative or life-threatening.[138] Intelligence among those with pure TS follows a normal curve, although there may be small differences in intelligence in those with comorbid conditions.[20][64] The severity of tics early in life does not predict their severity in later life.[35] There is no reliable means of predicting the course of symptoms for a particular individual,[104] but the prognosis is generally favorable.[104] By the age of fourteen to sixteen, when the highest tic severity has typically passed, a more reliable prognosis might be made.[118]

Tics may be at their highest severity when they are diagnosed, and often improve as an individual's family and friends come to better understand the condition.[14][39] Studies report that almost eight out of ten children with Tourette's experience a reduction in the severity of their tics by adulthood,[14][39] and some adults who still have tics may not be aware that they have them. A study that used video to record tics in adults found that nine out of ten adults still had tics, and half of the adults who considered themselves tic-free displayed evidence of mild tics.[14][139]

Quality of life

People with Tourette's are affected by the consequences of tics and by the efforts to suppress them.[140] Head and eye tics can interfere with reading or lead to headaches, and forceful tics can lead to repetitive strain injury.[141] Severe tics can lead to pain or injuries; as an example, a rare cervical disc herniation was reported from a neck tic.[47][67] Some people may learn to camouflage socially inappropriate tics or channel the energy of their tics into a functional endeavor.[36]

A supportive family and environment generally give those with Tourette's the skills to manage the disorder.[140][142][143] Outcomes in adulthood are associated more with the perceived significance of having tics as a child than with the actual severity of the tics. A person who was misunderstood, punished or teased at home or at school is likely to fare worse than a child who enjoyed an understanding environment.[36] The long-lasting effects of bullying and teasing can influence self-esteem, self-confidence, and even employment choices and opportunities.[140][144] Comorbid ADHD can severely affect the child's well-being in all realms, and extend into adulthood.[140]

Factors impacting quality of life change over time, given the natural fluctuating course of tic disorders, the development of coping strategies, and a person's age. As ADHD symptoms improve with maturity, adults report less negative impact in their occupational lives than do children in their educational lives.[140] Tics have a greater impact on adults' psychosocial function, including financial burdens, than they do on children.[118] Adults are more likely to report a reduced quality of life due to depression or anxiety;[140] depression contributes a greater burden than tics to adults' quality of life compared to children.[118] As coping strategies become more effective with age, the impact of OCD symptoms seems to diminish.[140]

Epidemiology

Tourette syndrome is a common but underdiagnosed condition[5] that reaches across all social, racial and ethnic groups.[4][31][35][145] It is three to four times more frequent in males than in females.[61] Observed prevalence rates are higher among children than adults because tics tend to remit or subside with maturity and a diagnosis may no longer be warranted for many adults.[38] Up to 1% of the overall population experiences tic disorders, including chronic tics and transient (provisional or unspecified) tics in childhood.[54] Chronic tics affect 5% of children and transient tics affect up to 20%.[61][122]

Many individuals with tics do not know they have tics,[20] or do not seek a diagnosis, so epidemiological studies of TS "reflect a strong ascertainment bias" towards those with co-occurring conditions.[51] The reported prevalence of TS varies "according to the source, age, and sex of the sample; the ascertainment procedures; and diagnostic system",[31] with a range reported between 0.15% and 3.0% for children and adolescents.[61] Sukhodolsky, et al. wrote in 2017 that the best estimate of TS prevalence in children was 1.4%.[61] Both Robertson[41] and Stern state that the prevalence in children is 1%.[2] The prevalence of TS in the general population is estimated as 0.3% to 1.0%.[5] According to turn of the century census data, these prevalence estimates translated to half a million children in the US with TS and half a million people in the UK with TS, although symptoms in many older individuals would be almost unrecognizable.[e]

Tourette syndrome was once thought to be rare: in 1972, the US National Institutes of Health (NIH) believed there were fewer than 100 cases in the United States,[146] and a 1973 registry reported only 485 cases worldwide.[147] However, numerous studies published since 2000 have consistently demonstrated that the prevalence is much higher.[148] Recognizing that tics may often be undiagnosed and hard to detect,[f] newer studies use direct classroom observation and multiple informants (parents, teachers and trained observers), and therefore record more cases than older studies.[111][151] As the diagnostic threshold and assessment methodology have moved towards recognition of milder cases, the estimated prevalence has increased.[148]

Because of the high male prevalence of TS, there is limited data on females from which conclusion about gender-based differences can be drawn; caution may be warranted in extending conclusions to females regarding the characteristics and treatment of tics based on studies of mostly males.[46] A 2021 review stated that females may see a later peak than males in symptoms, with less remission over time, along with a higher prevalence of anxiety and mood disorders.[46]

History

Main article: History of Tourette syndrome
 
Jean-Martin Charcot was a French neurologist and professor who named Tourette syndrome for his intern, Georges Gilles de la Tourette. In A Clinical Lesson at the Salpêtrière (1887), André Brouillet portrays a medical lecture by Charcot (the central standing figure) and shows de la Tourette in the audience (seated in the first row, wearing an apron).

A French doctor, Jean Marc Gaspard Itard, reported the first case of Tourette syndrome in 1825,[152] describing the Marquise de Dampierre, an important woman of nobility in her time.[153][154] In 1884, Jean-Martin Charcot, an influential French physician, assigned his student[155] and intern Georges Gilles de la Tourette, to study patients with movement disorders at the Salpêtrière Hospital, with the goal of defining a condition distinct from hysteria and chorea.[156] In 1885, Gilles de la Tourette published an account in Study of a Nervous Affliction of nine people with "convulsive tic disorder", concluding that a new clinical category should be defined.[157][158] The eponym was bestowed by Charcot after and on behalf of Gilles de la Tourette, who later became Charcot's senior resident.[34][159]

Following the 19th-century descriptions, a psychogenic view prevailed and little progress was made in explaining or treating tics until well into the 20th century.[34] The possibility that movement disorders, including Tourette syndrome, might have an organic origin was raised when an encephalitis lethargica epidemic from 1918 to 1926 was linked to an increase in tic disorders.[34][160]

During the 1960s and 1970s, as the beneficial effects of haloperidol on tics became known, the psychoanalytic approach to Tourette syndrome was questioned.[96][161] The turning point came in 1965, when Arthur K. Shapiro—described as "the father of modern tic disorder research"[162]—used haloperidol to treat a person with Tourette's, and published a paper criticizing the psychoanalytic approach.[160] In 1975, The New York Times headlined an article with "Bizarre outbursts of Tourette's disease victims linked to chemical disorder in brain", and Shapiro said: "The bizarre symptoms of this illness are rivaled only by the bizarre treatments used to treat it."[163]

During the 1990s, a more neutral view of Tourette's emerged, in which a genetic predisposition is seen to interact with non-genetic and environmental factors.[34][164][165] The fourth revision of the DSM (DSM-IV) in 1994 added a diagnostic requirement for "marked distress or significant impairment in social, occupational, or other important areas of functioning", which led to an outcry from TS experts and researchers, who noted that many people were not even aware they had TS, nor were they distressed by their tics; clinicians and researchers resorted to using the older criteria in research and practice.[7] In 2000, the American Psychiatric Association revised its diagnostic criteria in the fourth text revision of the DSM (DSM-IV-TR) to remove the impairment requirement,[84] recognizing that clinicians often see people who have Tourette's without distress or impairment.[90]

Society and culture

Main article: Societal and cultural aspects of Tourette syndrome
 
Samuel Johnson c. 1772. Johnson is likely to have had Tourette syndrome.

Not everyone with Tourette's wants treatment or a cure, especially if that means they may lose something else in the process.[114][166] The researchers Leckman and Cohen believe that there may be latent advantages associated with an individual's genetic vulnerability to developing Tourette syndrome that may have adaptive value, such as heightened awareness and increased attention to detail and surroundings.[167][168]

Accomplished musicians, athletes, public speakers and professionals from all walks of life are found among people with Tourette's.[89][169] The athlete Tim Howard, described by the Chicago Tribune as the "rarest of creatures—an American soccer hero",[170] and by the Tourette Syndrome Association as the "most notable individual with Tourette Syndrome around the world",[171] says that his neurological makeup gave him an enhanced perception and an acute focus that contributed to his success on the field.[137]

Samuel Johnson is a historical figure who likely had Tourette syndrome, as evidenced by the writings of his friend James Boswell.[172][173] Johnson wrote A Dictionary of the English Language in 1747, and was a prolific writer, poet, and critic. There is little support[174][175] for speculation that Mozart had Tourette's:[176] the potentially coprolalic aspect of vocal tics is not transferred to writing, so Mozart's scatological writings are not relevant; the composer's available medical history is not thorough; the side effects of other conditions may be misinterpreted; and "the evidence of motor tics in Mozart's life is doubtful".[177]

Likely portrayals of TS or tic disorders in fiction predating Gilles de la Tourette's work are "Mr. Pancks" in Charles Dickens's Little Dorrit and "Nikolai Levin" in Leo Tolstoy's Anna Karenina.[178] The entertainment industry has been criticized for depicting those with Tourette syndrome as social misfits whose only tic is coprolalia, which has furthered the public's misunderstanding and stigmatization of those with Tourette's.[179][180][181] The coprolalic symptoms of Tourette's are also fodder for radio and television talk shows in the US[182] and for the British media.[183] High-profile media coverage focuses on treatments that do not have established safety or efficacy, such as deep brain stimulation, and alternative therapies involving unstudied efficacy and side effects are pursued by many parents.[184]

Research directions

Further information: History of Tourette syndrome § Research directions and controversies

Research since 1999 has advanced knowledge of Tourette's in the areas of genetics, neuroimaging, neurophysiology, and neuropathology, but questions remain about how best to classify it and how closely it is related to other movement or psychiatric disorders.[4][13][14][15] Modeled after genetic breakthroughs seen with large-scale efforts in other neurodevelopmental disorders, three groups are collaborating in research of the genetics of Tourette's:

  • The Tourette Syndrome Association International Consortium for Genetics (TSAICG)
  • Tourette International Collaborative Genetics Study (TIC Genetics)
  • European Multicentre Tics in Children Studies (EMTICS)

Compared to the progress made in gene discovery in certain neurodevelopmental or mental health disorders—autism, schizophrenia and bipolar disorder—the scale of related TS research is lagging in the United States due to funding.[185]

Notes

  1. ^ According to Dale (2017), over time, 15% of people with tics have only TS (85% of people with Tourette's will develop a co-occurring condition).[14] In a 2017 literature review, Sukhodolsky, et al. stated that 37% of individuals in clinical samples had pure TS.[61] Denckla (2006) reported that a review of patient records revealed that about 40% of people with Tourette's have TS-only.[62][63] Dure and DeWolfe (2006) reported that 57% of 656 individuals presenting with tic disorders had tics uncomplicated by other conditions.[23]
  2. ^ There were no changes in the fifth text revision of 2022, DSM-5-TR.[83]
  3. ^ The YGTSS is considered the gold standard in tic assessment.[5]
  4. ^ Movement disorders without an organic cause have been referred to over time using terms such as hysterical, psychogenic and psychogenic movement disorders;[99][100] DSM-5 classifies them under functional neurological symptom disorder/conversion disorder.[101]
  5. ^ A prevalence range of 0.1% to 1% yields an estimate of 53,000 to 530,000 school-age children with Tourette's in the United States, using 2000 census data.[54] In the United Kingdom, a prevalence estimate of 1.0% based on the 2001 census meant that about half a million people aged five or older would have Tourette's, although symptoms in older individuals would be almost unrecognizable.[42] Prevalence rates in special education populations are higher.[41]
  6. ^ The discrepancy between current and prior prevalence estimates arises from several factors: the ascertainment bias caused by samples that were drawn from clinically referred cases; assessment methods that failed to detect milder cases; and the use of different diagnostic criteria and thresholds.[148] There were few broad-based community studies published before 2000, and most older epidemiological studies were based only on individuals referred to tertiary care or specialty clinics.[51][149] People with mild symptoms may not have sought treatment and physicians may have avoided an official diagnosis of TS in children due to concerns about stigmatization.[43] Studies are vulnerable to further error because tics vary in intensity and expression, are often intermittent, and are not always recognized by clinicians, individuals with TS, family members, friends or teachers.[37][150]

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  165. ^ Cohen DJ, Leckman JF (January 1994). "Developmental psychopathology and neurobiology of Tourette's syndrome". J Am Acad Child Adolesc Psychiatry (Review). 33 (1): 2–15. doi:10.1097/00004583-199401000-00002. PMID 8138517. [Pathogenesis of tic disorders involves] interactions among genetic factors, neurobiological substrates, and environmental factors in the production of the clinical phenotypes. The genetic vulnerability factors that underlie Tourette's syndrome and other tic disorders undoubtedly influence the structure and function of the brain, in turn producing clinical symptoms. Available evidence ... also indicates that a range of epigenetic or environmental factors ... are critically involved in the pathogenesis of these disorders.
  166. ^ Leckman & Cohen (1999), p. 408.
  167. ^ Leckman & Cohen (1999), pp. 18–19, 148–151, 408.
  168. ^ Müller-Vahl (2013), p. 624; "... a few 'positive' aspects may be closely linked to TS. People with TS, for example, may have positive personality characteristics and talents such as punctuality, correctness, conscientiousness, a sense of justice, quick comprehension, good intelligence, creativity, musicality, and athletic abilities. For that reason, some people with TS even hesitate when asked whether they wish the disorder would disappear completely".
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  175. ^ Bhattacharyya KB, Rai S (2015). "Famous people with Tourette's syndrome: Dr. Samuel Johnson (yes) & Wolfgang Amadeus Mozart (may be): Victims of Tourette's syndrome?". Ann Indian Acad Neurol. 18 (2): 157–161. doi:10.4103/0972-2327.145288. PMC 4445189. PMID 26019411.
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    • Kammer T (2007). (PDF). In Bogousslavsky J, Hennerici MG (eds.). Neurological Disorders in Famous Artists - Part 2 (Historical biography). Frontiers of Neurology and Neuroscience. Vol. 22. Basel: Karger. pp. 184–192. doi:10.1159/000102880. ISBN 978-3-8055-8265-0. PMID 17495512. Archived from the original (PDF) on February 7, 2012.
    • Ashoori A, Jankovic J (November 2007). "Mozart's movements and behaviour: a case of Tourette's syndrome?". J. Neurol. Neurosurg. Psychiatry (Historical biography). 78 (11): 1171–1175. doi:10.1136/jnnp.2007.114520. PMC 2117611. PMID 17940168.
    • Sacks O (1992). "Tourette's syndrome and creativity". BMJ (Editorial comment). 305 (6868): 1515–1516. doi:10.1136/bmj.305.6868.1515. PMC 1884721. PMID 1286364.
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  180. ^ Lim Fat MJ, Sell E, Barrowman N, Doja A (2012). "Public perception of Tourette syndrome on YouTube". Journal of Child Neurology. 27 (8): 1011–1016. CiteSeerX 10.1.1.997.9069. doi:10.1177/0883073811432294. PMID 22821136. S2CID 21648806.
  181. ^ Holtgren B (January 11, 2006). "Truth about Tourette's not what you think". Cincinnati Enquirer. As medical problems go, Tourette's is, except in the most severe cases, about the most minor imaginable thing to have. ... the freak-show image, unfortunately, still prevails overwhelmingly. The blame for the warped perceptions lies overwhelmingly with the video media—the Internet, movies and TV. If you search for 'Tourette' on Google or YouTube, you'll get a gazillion hits that almost invariably show the most outrageously extreme examples of motor and vocal tics. Television, with notable exceptions such as Oprah, has sensationalized Tourette's so badly, for so long, that it seems beyond hope that most people will ever know the more prosaic truth.
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    • (Press release). Tourette Syndrome Association. May 31, 2001. Archived from the original on October 6, 2001. Retrieved December 21, 2011.
    • (Press release). Tourette Syndrome Association. Archived from the original on August 31, 2008. Retrieved December 21, 2011.
    • (Press release). Tourette Syndrome Association. Archived from the original on February 7, 2009. Retrieved December 21, 2011.
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  184. ^ Swerdlow NR (September 2005). "Tourette syndrome: current controversies and the battlefield landscape". Curr Neurol Neurosci Rep. 5 (5): 329–331. doi:10.1007/s11910-005-0054-8. PMID 16131414. S2CID 26342334.
  185. ^ Fernandez TV, State MW, Pittenger C (2018). "Tourette disorder and other tic disorders". Neurogenetics, Part I (Review). Handbook of Clinical Neurology. Vol. 147. pp. 343–354. doi:10.1016/B978-0-444-63233-3.00023-3. ISBN 978-0-444-63233-3. PMID 29325623. Regardless of whether the focus is on discovering rare or common sequence or structural genetic variation, it is clear that large collections of biomaterials (likely in the tens of thousands) that are accessible by multiple research groups will be essential for success. Three consortia are now beginning to work toward this goal (TSAICG and TIC Genetics in the United States, and EMTics in the European Union); there is active collaboration among these groups, which will also be essential for success. However, the scale of the funded collection efforts, particularly in the United States, remains quite modest compared to other neuropsychiatric disorders in which there has been success in gene discovery.

Book sources

  • Abi-Jaoude E, Kideckel D, Stephens R, et al. (2009). "Tourette syndrome: a model of integration". In Carlstedt RA (ed.). Handbook of Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine: Perspectives, Practices, and Research. New York: Springer Publishing Company. ISBN 978-0-8261-1095-4.
  • Cohen DJ, Jankovic J, Goetz CG, eds. (2001). Tourette Syndrome. Advances in Neurology. Vol. 85. Philadelphia, PA: Lippincott Williams & Wilkins. ISBN 0-7817-2405-8.
  • Kushner HI (2000). A Cursing Brain?: The Histories of Tourette Syndrome. Harvard University Press. ISBN 0-674-00386-1.
  • Leckman JF, Cohen DJ (1999). Tourette's Syndrome—Tics, Obsessions, Compulsions: Developmental Psychopathology and Clinical Care. New York: John Wiley & Sons, Inc. ISBN 978-0471160373.
  • Martino D, Leckman JF, eds. (2013). Tourette syndrome. Oxford University Press. ISBN 978-0199796267.
    • Bloch MH (2013). "Clinical course and adult outcome in Tourette syndrome". In Martino D, Leckman JF (eds.). Tourette syndrome. Oxford University Press. pp. 107–120.
    • Müller-Vahl KR (2013). "Information and social support for patients and families". In Martino D, Leckman JF (eds.). Tourette syndrome. Oxford University Press. pp. 623–635.
    • Pruitt SK, Packer LE (2013). "Tourette syndrome". In Martino D, Leckman JF (eds.). Information and support for educators. Oxford University Press. pp. 636–655.
  • Sukhodolsky DG, Gladstone TR, Kaushal SA, Piasecka JB, Leckman JF (2017). "Tics and Tourette Syndrome". In Matson JL (ed.). Handbook of Childhood Psychopathology and Developmental Disabilities Treatment. Autism and Child Psychopathology Series. Springer. pp. 241–256. doi:10.1007/978-3-319-71210-9_14. ISBN 978-3-319-71209-3.
  • Walkup JT, Mink JW, Hollenback PJ, eds. (2006). Advances in Neurology, Tourette Syndrome. Vol. 99. Philadelphia, PA: Lippincott Williams & Wilkins. ISBN 0-7817-9970-8.
  • Walusinski O (2019). Georges Gilles de la Tourette: Beyond the Eponym, a Biography. Oxford University Press. ISBN 978-0-19-063603-6.

Further reading

  • McGuire JF, Murphy TK, Piacentini J, Storch EA (2018). The Clinician's Guide to Treatment and Management of Youth with Tourette Syndrome and Tic Disorders. Academic Press. ISBN 978-0128119808.
  • Olson S (September 2004). "Neurobiology. Making sense of Tourette's". Science. 305 (5689): 1390–92. doi:10.1126/science.305.5689.1390. PMID 15353772. S2CID 177963554.

External links

 
Wikimedia Commons has media related to Tourette syndrome.

January 01, 1970
tourette, syndrome, tourette, redirects, here, other, uses, tourette, disambiguation, tourette, syndrome, abbreviated, tourette, common, neurodevelopmental, disorder, that, begins, childhood, adolescence, characterized, multiple, movement, motor, tics, least, . Tourette redirects here For other uses see Tourette disambiguation Tourette syndrome or Tourette s syndrome abbreviated as TS or Tourette s is a common neurodevelopmental disorder that begins in childhood or adolescence It is characterized by multiple movement motor tics and at least one vocal phonic tic Common tics are blinking coughing throat clearing sniffing and facial movements These are typically preceded by an unwanted urge or sensation in the affected muscles known as a premonitory urge can sometimes be suppressed temporarily and characteristically change in location strength and frequency Tourette s is at the more severe end of a spectrum of tic disorders The tics often go unnoticed by casual observers Tourette syndromeOther namesTourette s syndrome Tourette s disorder Gilles de la Tourette syndrome GTS combined vocal and multiple motor tic disorder de la Tourette Georges Gilles de la Tourette 1857 1904 namesake of Tourette syndromeSpecialtyPediatrics neurology psychiatry 1 SymptomsTics 2 Usual onsetTypically in childhood 2 DurationLong term 3 CausesGenetic with environmental influence 3 Diagnostic methodBased on history and symptoms 2 MedicationUsually none occasionally neuroleptics and noradrenergics 2 Prognosis80 will experience improvement to disappearance of tics beginning in late teens 3 FrequencyAbout 1 of children and adolescents 4 Between 0 3 and 1 0 of general population 5 Tourette s was once regarded as a rare and bizarre syndrome and has popularly been associated with coprolalia the utterance of obscene words or socially inappropriate and derogatory remarks It is no longer considered rare about 1 of school age children and adolescents are estimated to have Tourette s 2 though coprolalia occurs only in a minority There are no specific tests for diagnosing Tourette s it is not always correctly identified because most cases are mild and the severity of tics decreases for most children as they pass through adolescence Therefore many go undiagnosed or may never seek medical attention Extreme Tourette s in adulthood though sensationalized in the media is rare but for a small minority severely debilitating tics can persist into adulthood Tourette s does not affect intelligence or life expectancy There is no cure for Tourette s and no single most effective medication In most cases medication for tics is not necessary and behavioral therapies are the first line treatment Education is an important part of any treatment plan and explanation alone often provides sufficient reassurance that no other treatment is necessary 2 Other conditions such as attention deficit hyperactivity disorder ADHD and obsessive compulsive disorder OCD are more likely to be present among those who are referred to specialty clinics than they are among the broader population of persons with Tourette s These co occurring conditions often cause more impairment to the individual than the tics hence it is important to correctly distinguish co occurring conditions and treat them Tourette syndrome was named by French neurologist Jean Martin Charcot for his intern Georges Gilles de la Tourette who published in 1885 an account of nine patients with a convulsive tic disorder While the exact cause is unknown it is believed to involve a combination of genetic and environmental factors The mechanism appears to involve dysfunction in neural circuits between the basal ganglia and related structures in the brain Contents 1 Classification 2 Characteristics 2 1 Tics 2 2 Onset and progression 2 3 Co occurring conditions 2 4 Neuropsychological function 3 Causes 4 Mechanism 5 Diagnosis 5 1 Differential diagnosis 5 2 Screening for other conditions 6 Management 6 1 Psychoeducation and social support 6 2 Behavioral 6 3 Medication 6 4 Other 6 5 Pregnancy 7 Prognosis 7 1 Quality of life 8 Epidemiology 9 History 10 Society and culture 11 Research directions 12 Notes 13 References 13 1 Book sources 14 Further reading 15 External linksClassificationMost published research on Tourette syndrome originates in the United States in international TS research and clinical practice the Diagnostic and Statistical Manual of Mental Disorders DSM is preferred over the World Health Organization WHO classification 5 7 8 which is criticized in the 2021 European Clinical Guidelines 1 In the fifth version of the DSM DSM 5 published in 2013 Tourette syndrome is classified as a motor disorder a disorder of the nervous system that causes abnormal and involuntary movements It is listed in the neurodevelopmental disorder category 9 Tourette s is at the more severe end of the spectrum of tic disorders its diagnosis requires multiple motor tics and at least one vocal tic to be present for more than a year Tics are sudden repetitive nonrhythmic movements that involve discrete muscle groups 10 while vocal phonic tics involve laryngeal pharyngeal oral nasal or respiratory muscles to produce sounds 11 12 The tics must not be explained by other medical conditions or substance use 13 Other tic disorders include persistent chronic motor or vocal tics in which one type of tic motor or vocal but not both has been present for more than a year and provisional tic disorder in which motor or vocal tics have been present for less than one year 14 15 The fifth edition of the DSM replaced what had been called transient tic disorder with provisional tic disorder recognizing that transient can only be defined in retrospect 7 16 17 Some experts believe that TS and persistent chronic motor or vocal tic disorder should be considered the same condition because vocal tics are also motor tics in the sense that they are muscular contractions of nasal or respiratory muscles 5 6 15 Tourette syndrome is defined only slightly differently by the WHO 4 8 in its ICD 11 the International Statistical Classification of Diseases and Related Health Problems Tourette syndrome is classified as a disease of the nervous system and a neurodevelopmental disorder 18 19 and only one motor tic and one or more vocal tics are required for diagnosis 20 Older versions of the ICD called it combined vocal and multiple motor tic disorder de la Tourette 21 Genetic studies indicate that tic disorders cover a spectrum that is not recognized by the clear cut distinctions in the current diagnostic framework 13 Since 2008 studies have suggested that Tourette s is not a unitary condition with a distinct mechanism as described in the existing classification systems Instead the studies suggest that subtypes should be recognized to distinguish pure TS from TS that is accompanied by attention deficit hyperactivity disorder ADHD obsessive compulsive disorder OCD or other disorders similar to the way that subtypes have been established for other conditions such as type 1 and type 2 diabetes 4 13 20 Elucidation of these subtypes awaits fuller understanding of the genetic and other causes of tic disorders 7 CharacteristicsTics source source source source Examples of tics Tics are movements or sounds that take place intermittently and unpredictably out of a background of normal motor activity 22 having the appearance of normal behaviors gone wrong 23 The tics associated with Tourette s wax and wane they change in number frequency severity anatomical location and complexity 5 each person experiences a unique pattern of fluctuation in their severity and frequency Tics may also occur in bouts of bouts which also vary among people 24 The variation in tic severity may occur over hours days or weeks 14 Tics may increase when someone is experiencing stress fatigue anxiety or illness 13 25 or when engaged in relaxing activities like watching TV They sometimes decrease when an individual is engrossed in or focused on an activity like playing a musical instrument 13 26 In contrast to the abnormal movements associated with other movement disorders the tics of Tourette s are nonrhythmic often preceded by an unwanted urge and temporarily suppressible 24 27 Over time about 90 of individuals with Tourette s feel an urge preceding the tic 14 similar to the urge to sneeze or scratch an itch The urges and sensations that precede the expression of a tic are referred to as premonitory sensory phenomena or premonitory urges People describe the urge to express the tic as a buildup of tension pressure or energy 28 29 which they ultimately choose consciously to release as if they had to do it 30 to relieve the sensation 28 or until it feels just right 30 31 The urge may cause a distressing sensation in the part of the body associated with the resulting tic the tic is a response that relieves the urge in the anatomical location of the tic 2 24 Examples of this urge are the feeling of having something in one s throat leading to a tic to clear one s throat or a localized discomfort in the shoulders leading to shrugging the shoulders The actual tic may be felt as relieving this tension or sensation similar to scratching an itch or blinking to relieve an uncomfortable feeling in the eye 2 22 Some people with Tourette s may not be aware of the premonitory urge associated with tics Children may be less aware of it than are adults 14 but their awareness tends to increase with maturity 22 by the age of ten most children recognize the premonitory urge 26 Premonitory urges which precede the tic make suppression of the impending tic possible 24 Because of the urges that precede them tics are described as semi voluntary or unvoluntary 2 22 rather than specifically involuntary they may be experienced as a voluntary suppressible response to the unwanted premonitory urge 24 26 The ability to suppress tics varies among individuals and may be more developed in adults than children 32 People with tics are sometimes able to suppress them for limited periods of time but doing so often results in tension or mental exhaustion 2 33 People with Tourette s may seek a secluded spot to release the suppressed urge or there may be a marked increase in tics after a period of suppression at school or work 14 23 Children may suppress tics while in the doctor s office so they may need to be observed when not aware of being watched 34 Complex tics related to speech include coprolalia echolalia and palilalia Coprolalia is the spontaneous utterance of socially objectionable or taboo words or phrases Although it is the most publicized symptom of Tourette s only about 10 of people with Tourette s exhibit it and it is not required for a diagnosis 2 35 Echolalia repeating the words of others and palilalia repeating one s own words occur in a minority of cases 36 Complex motor tics include copropraxia obscene or forbidden gestures or inappropriate touching echopraxia repetition or imitation of another person s actions and palipraxia repeating one s own movements 32 Onset and progression There is no typical case of Tourette syndrome 37 but the age of onset and the severity of symptoms follow a fairly reliable course Although onset may occur anytime before eighteen years the typical age of onset of tics is from five to seven and is usually before adolescence 2 A 1998 study from the Yale Child Study Center showed that tic severity increased with age until it reached its highest point between ages eight and twelve 38 Severity declines steadily for most children as they pass through adolescence when half to two thirds of children see a dramatic decrease in tics 39 In people with TS the first tics to appear usually affect the head face and shoulders and include blinking facial movements sniffing and throat clearing 14 Vocal tics often appear months or years after motor tics but can appear first 7 15 Among people who experience more severe tics complex tics may develop including arm straightening touching tapping jumping hopping and twirling 14 There are different movements in contrasting disorders for example the autism spectrum disorders such as self stimulation and stereotypies 40 The severity of symptoms varies widely among people with Tourette s and many cases may be undetected 2 4 15 36 Most cases are mild and almost unnoticeable 41 42 many people with TS may not realize they have tics Because tics are more commonly expressed in private Tourette syndrome may go unrecognized 43 and casual observers might not notice tics 35 44 45 Most studies of TS involve males who have a higher prevalence of TS than females and gender based differences are not well studied a 2021 review suggested that the characteristics and progression for females particularly in adulthood may differ and better studies are needed 46 Most adults with TS have mild symptoms and do not seek medical attention 2 While tics subside for the majority after adolescence some of the most severe and debilitating forms of tic disorder are encountered in adults 47 In some cases what appear to be adult onset tics can be childhood tics re surfacing 47 Co occurring conditions nbsp Andre Malraux center was a French Minister of Culture author and adventurer who may have had Tourette syndrome 48 49 50 Because people with milder symptoms are unlikely to be referred to specialty clinics studies of Tourette s have an inherent bias towards more severe cases 51 52 When symptoms are severe enough to warrant referral to clinics ADHD and OCD are often also found 2 In specialty clinics 30 of those with TS also have mood or anxiety disorders or disruptive behaviors 14 53 In the absence of ADHD tic disorders do not appear to be associated with disruptive behavior or functional impairment 54 while impairment in school family or peer relations is greater in those who have more comorbid conditions 23 55 When ADHD is present along with tics the occurrence of conduct disorder and oppositional defiant disorder increases 14 Aggressive behaviors and angry outbursts in people with TS are not well understood they are not associated with severe tics but are connected with the presence of ADHD 56 ADHD may also contribute to higher rates of anxiety and aggression and anger control problems are more likely when both OCD and ADHD co occur with Tourette s 47 Compulsions that resemble tics are present in some individuals with OCD tic related OCD is hypothesized to be a subgroup of OCD distinguished from non tic related OCD by the type and nature of obsessions and compulsions 57 Compared to the more typical compulsions of OCD without tics that relate to contamination tic related OCD presents with more counting aggressive thoughts symmetry and touching compulsions 14 Compulsions associated with OCD without tics are usually related to obsessions and anxiety while those in tic related OCD are more likely to be a response to a premonitory urge 14 58 There are increased rates of anxiety and depression in those adults with TS who also have OCD 47 Among individuals with TS studied in clinics between 2 9 and 20 had autism spectrum disorders 59 but one study indicates that a high association of autism and TS may be partly due to difficulties distinguishing between tics and tic like behaviors or OCD symptoms seen in people with autism 60 Not all people with Tourette s have ADHD or OCD or other comorbid conditions and estimates of the rate of pure TS or TS only vary from 15 to 57 a in clinical populations a high percentage of those under care do have ADHD 31 61 Children and adolescents with pure TS are not significantly different from their peers without TS on ratings of aggressive behaviors or conduct disorders or on measures of social adaptation 4 Similarly adults with pure TS do not appear to have the social difficulties present in those with TS plus ADHD 4 Among those with an older age of onset more substance abuse and mood disorders are found and there may be self injurious tics Adults who have severe often treatment resistant tics are more likely to also have mood disorders and OCD 47 Coprolalia is more likely in people with severe tics plus multiple comorbid conditions 32 Neuropsychological function There are no major impairments in neuropsychological function among people with Tourette s but conditions that occur along with tics can cause variation in neurocognitive function A better understanding of comorbid conditions is needed to untangle any neuropsychological differences between TS only individuals and those with comorbid conditions 55 Only slight impairments are found in intellectual ability attentional ability and nonverbal memory but ADHD other comorbid disorders or tic severity could account for these differences In contrast with earlier findings visual motor integration and visuoconstructive skills are not found to be impaired while comorbid conditions may have a small effect on motor skills Comorbid conditions and severity of tics may account for variable results in verbal fluency which can be slightly impaired There might be slight impairment in social cognition but not in the ability to plan or make decisions 55 Children with TS only do not show cognitive deficits They are faster than average for their age on timed tests of motor coordination and constant tic suppression may lead to an advantage in switching between tasks because of increased inhibitory control 4 63 Learning disabilities may be present but whether they are due to tics or comorbid conditions is controversial older studies that reported higher rates of learning disability did not control well for the presence of comorbid conditions 64 There are often difficulties with handwriting and disabilities in written expression and math are reported in those with TS plus other conditions 64 CausesMain article Causes and origins of Tourette syndrome The exact cause of Tourette s is unknown but it is well established that both genetic and environmental factors are involved 13 14 65 Genetic epidemiology studies have shown that Tourette s is highly heritable 66 and 10 to 100 times more likely to be found among close family members than in the general population 67 The exact mode of inheritance is not known no single gene has been identified 5 and hundreds of genes are likely involved 51 66 67 Genome wide association studies were published in 2013 2 and 2015 14 in which no finding reached a threshold for significance 2 a 2019 meta analysis found only a single genome wide significant locus on chromosome 13 but that result was not found in broader samples 68 Twin studies show that 50 to 77 of identical twins share a TS diagnosis while only 10 to 23 of fraternal twins do 13 But not everyone who inherits the genetic vulnerability will show symptoms 69 70 A few rare highly penetrant genetic mutations have been found that explain only a small number of cases in single families the SLITRK1 HDC and CNTNAP2 genes 71 Psychosocial or other non genetic factors while not causing Tourette s can affect the severity of TS in vulnerable individuals and influence the expression of the inherited genes 4 37 65 67 Pre natal and peri natal events increase the risk that a tic disorder or comorbid OCD will be expressed in those with the genetic vulnerability These include paternal age forceps delivery stress or severe nausea during pregnancy and use of tobacco caffeine alcohol 4 20 and cannabis during pregnancy 2 Babies who are born premature with low birthweight or who have low Apgar scores are also at increased risk in premature twins the lower birthweight twin is more likely to develop TS 4 Autoimmune processes may affect the onset of tics or exacerbate them Both OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post streptococcal autoimmune process 72 Its potential effect is described by the controversial 72 hypothesis called PANDAS pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections which proposes five criteria for diagnosis in children 73 74 PANDAS and the newer pediatric acute onset neuropsychiatric syndrome PANS hypotheses are the focus of clinical and laboratory research but remain unproven 73 There is also a broader hypothesis that links immune system abnormalities and immune dysregulation with TS 14 72 Some forms of OCD may be genetically linked to Tourette s 31 although the genetic factors in OCD with and without tics may differ 13 The genetic relationship of ADHD to Tourette syndrome however has not been fully established 53 63 75 A genetic link between autism and Tourette s has not been established as of 2017 47 Mechanism nbsp The basal ganglia and thalamus are implicated in Tourette syndrome The exact mechanism affecting the inherited vulnerability to Tourette s is not well established 13 Tics are believed to result from dysfunction in cortical and subcortical brain regions the thalamus basal ganglia and frontal cortex 76 Neuroanatomic models suggest failures in circuits connecting the brain s cortex and subcortex 37 imaging techniques implicate the frontal cortex and basal ganglia 51 In the 2010s neuroimaging and postmortem brain studies as well as animal and genetic studies 55 77 made progress towards better understanding the neurobiological mechanisms leading to Tourette s 55 These studies support the basal ganglia model in which neurons in the striatum are activated and inhibit outputs from the basal ganglia 56 Cortico striato thalamo cortical CSTC circuits or neural pathways provide inputs to the basal ganglia from the cortex These circuits connect the basal ganglia with other areas of the brain to transfer information that regulates planning and control of movements behavior decision making and learning 55 Behavior is regulated by cross connections that allow the integration of information from these circuits 55 Involuntary movements may result from impairments in these CSTC circuits 55 including the sensorimotor limbic language and decision making pathways Abnormalities in these circuits may be responsible for tics and premonitory urges 78 The caudate nuclei may be smaller in subjects with tics compared to those without tics supporting the hypothesis of pathology in CSTC circuits in Tourette s 55 The ability to suppress tics depends on brain circuits that regulate response inhibition and cognitive control of motor behavior 77 Children with TS are found to have a larger prefrontal cortex which may be the result of an adaptation to help regulate tics 77 It is likely that tics decrease with age as the capacity of the frontal cortex increases 77 Cortico basal ganglia CBG circuits may also be impaired contributing to sensory limbic and executive features 14 The release of dopamine in the basal ganglia is higher in people with Tourette s implicating biochemical changes from overactive and dysregulated dopaminergic transmissions 65 Histamine and the H3 receptor may play a role in the alterations of neural circuitry 14 79 80 81 A reduced level of histamine in the H3 receptor may result in an increase in other neurotransmitters causing tics 82 Postmortem studies have also implicated dysregulation of neuroinflammatory processes 13 DiagnosisAccording to the Diagnostic and Statistical Manual of Mental Disorders DSM 5 b Tourette s may be diagnosed when a person exhibits both multiple motor tics and one or more vocal tics over a period of one year The motor and vocal tics need not be concurrent The onset must have occurred before the age of 18 and cannot be attributed to the effects of another condition or substance such as cocaine 9 Hence other medical conditions that include tics or tic like movements for example autism or other causes of tics must be ruled out 84 Patients referred for a tic disorder are assessed based on their family history of tics vulnerability to ADHD obsessive compulsive symptoms and a number of other chronic medical psychiatric and neurological conditions 85 86 In individuals with a typical onset and a family history of tics or OCD a basic physical and neurological examination may be sufficient 87 There are no specific medical or screening tests that can be used to diagnose Tourette s 31 the diagnosis is usually made based on observation of the individual s symptoms and family history 35 and after ruling out secondary causes of tic disorders tourettism 88 Delayed diagnosis often occurs because professionals mistakenly believe that TS is rare always involves coprolalia or must be severely impairing 89 The DSM has recognized since 2000 that many individuals with Tourette s do not have significant impairment 7 84 90 diagnosis does not require the presence of coprolalia or a comorbid condition such as ADHD or OCD 35 89 Tourette s may be misdiagnosed because of the wide expression of severity ranging from mild in the majority of cases or moderate to severe the rare but more widely recognized and publicized cases 38 About 20 of people with Tourette syndrome do not realize that they have tics 37 Tics that appear early in the course of TS are often confused with allergies asthma vision problems and other conditions Pediatricians allergists and ophthalmologists are among the first to see or identify a child as having tics 5 36 91 although the majority of tics are first identified by the child s parents 89 Coughing blinking and tics that mimic unrelated conditions such as asthma are commonly misdiagnosed 35 In the UK there is an average delay of three years between symptom onset and diagnosis 4 Differential diagnosis Main screening and assessment tools 92 93 Yale Global Tic Severity Scale YGTSS recommended in international guidelines to assess frequency intensity complexity distribution interference and impairment of or due to tics c Tourette Syndrome Clinical Global Impression TS CGI and Shapiro TS Severity Scale STSS for a briefer assessment of tics than YGTSSTourette s Disorder Scale TODS to assess tics and comorbiditiesPremonitory Urge for Tics Scale PUTS for individuals over age tenMotor tic Obsessions and compulsions Vocal tic Evaluation Survey MOVES to evaluate complex tics and other behaviorsAutism Tics AD HD and other Comorbities A TAC to screen for other conditions Tics that may appear to mimic those of Tourette s but are associated with disorders other than Tourette s are known as tourettism 94 and are ruled out in the differential diagnosis for Tourette syndrome 87 The abnormal movements associated with choreas dystonias myoclonus and dyskinesias are distinct from the tics of Tourette s in that they are more rhythmic not suppressible and not preceded by an unwanted urge 24 27 Developmental and autism spectrum disorders may manifest tics other stereotyped movements 95 and stereotypic movement disorder 96 97 The stereotyped movements associated with autism typically have an earlier age of onset are more symmetrical rhythmical and bilateral and involve the extremities for example flapping the hands 40 If another condition might better explain the tics tests may be done for example if there is diagnostic confusion between tics and seizure activity an EEG may be ordered An MRI can rule out brain abnormalities but such brain imaging studies are not usually warranted 85 Measuring thyroid stimulating hormone blood levels can rule out hypothyroidism which can be a cause of tics If there is a family history of liver disease serum copper and ceruloplasmin levels can rule out Wilson s disease 87 The typical age of onset of TS is before adolescence 2 In teenagers and adults with an abrupt onset of tics and other behavioral symptoms a urine drug screen for stimulants might be requested 87 Increasing episodes of tic like behavior among teenagers predominantly adolescent girls were reported in several countries during the COVID 19 pandemic 20 91 Researchers linked their occurrence to followers of certain TikTok or YouTube artists 5 91 Described in 2006 as psychogenic 96 abrupt onset movements resembling tics are referred to as a functional movement disorder 98 or functional tic like movements 91 d Functional tic like movements can be difficult to distinguish from tics that have an organic rather than psychological cause 98 100 They may occur alone or co exist in individuals with tic disorders 98 102 These tics are inconsistent with the classic tics of TS in several ways 103 the premonitory urge present in 90 of those with tics disorders 99 is absent in functional tic like movements the suppressibility seen in tic disorders is lacking 98 99 100 101 there is no family or childhood history of tics and there is a female predominance in functional tics 91 with a later than typical age of first presentation 98 99 100 onset is more abrupt than typical with movements that are more suggestible 99 and there is less co occurring OCD or ADHD and more co occurring disorders 100 Functional tics are not fully stereotypical 101 do not respond to medications do not demonstrate the classic waxing and waning pattern of Tourettic tics 98 and do not progress in the typical fashion in which tics often first appear in the face and gradually move to limbs 100 Other conditions that may manifest tics include Sydenham s chorea idiopathic dystonia and genetic conditions such as Huntington s disease neuroacanthocytosis pantothenate kinase associated neurodegeneration Duchenne muscular dystrophy Wilson s disease and tuberous sclerosis Other possibilities include chromosomal disorders such as Down syndrome Klinefelter syndrome XYY syndrome and fragile X syndrome Acquired causes of tics include drug induced tics head trauma encephalitis stroke and carbon monoxide poisoning 87 94 The extreme self injurious behaviors of Lesch Nyhan syndrome may be confused with Tourette syndrome or stereotypies but self injury is rare in TS even in cases of violent tics 40 Most of these conditions are rarer than tic disorders and a thorough history and examination may be enough to rule them out without medical or screening tests 2 37 94 Screening for other conditions Although not all those with Tourette s have comorbid conditions most presenting for clinical care exhibit symptoms of other conditions along with their tics 63 ADHD and OCD are the most common but autism spectrum disorders or anxiety mood personality oppositional defiant and conduct disorders may also be present 11 Learning disabilities and sleep disorders may be present 35 higher rates of sleep disturbance and migraine than in the general population are reported 104 105 A thorough evaluation for comorbidity is called for when symptoms and impairment warrant 86 87 and careful assessment of people with TS includes comprehensive screening for these conditions 11 67 Comorbid conditions such as OCD and ADHD can be more impairing than tics and cause greater impact on overall functioning 6 37 Disruptive behaviors impaired functioning or cognitive impairment in individuals with comorbid Tourette s and ADHD may be accounted for by the ADHD highlighting the importance of identifying comorbid conditions 14 31 35 106 Children and adolescents with TS who have learning difficulties are candidates for psychoeducational testing particularly if the child also has ADHD 85 86 ManagementMain article Management of Tourette syndrome There is no cure for Tourette s 107 There is no single most effective medication 2 and no one medication effectively treats all symptoms Most medications prescribed for tics have not been approved for that use and no medication is without the risk of significant adverse effects 6 35 108 Treatment is focused on identifying the most troubling or impairing symptoms and helping the individual manage them 35 Because comorbid conditions are often a larger source of impairment than tics 20 they are a priority in treatment 109 The management of Tourette s is individualized and involves shared decision making between the clinician patient family and caregivers 109 110 Practice guidelines for the treatment of tics were published by the American Academy of Neurology in 2019 109 Education reassurance and psychobehavioral therapy are often sufficient for the majority of cases 2 35 111 In particular psychoeducation targeting the patient and their family and surrounding community is a key management strategy 112 113 Watchful waiting is an acceptable approach for those who are not functionally impaired 109 Symptom management may include behavioral psychological and pharmacological therapies Pharmacological intervention is reserved for more severe symptoms while psychotherapy or cognitive behavioral therapy CBT may ameliorate depression and social isolation and improve family support 35 The decision to use behavioral or pharmacological treatment is usually made after the educational and supportive interventions have been in place for a period of months and it is clear that the tic symptoms are persistently severe and are themselves a source of impairment in terms of self esteem relationships with the family or peers or school performance 93 Psychoeducation and social support Further information Management of Tourette syndrome Psychoeducation and social support Knowledge education and understanding are uppermost in management plans for tic disorders 35 and psychoeducation is the first step 114 115 A child s parents are typically the first to notice their tics 89 they may feel worried imagine that they are somehow responsible or feel burdened by misinformation about Tourette s 114 Effectively educating parents about the diagnosis and providing social support can ease their anxiety This support can also lower the chance that their child will be unnecessarily medicated 116 or experience an exacerbation of tics due to their parents emotional state 11 People with Tourette s may suffer socially if their tics are viewed as bizarre If a child has disabling tics or tics that interfere with social or academic functioning supportive psychotherapy or school accommodations can be helpful 88 Even children with milder tics may be angry depressed or have low self esteem as a result of increased teasing bullying rejection by peers or social stigmatization and this can lead to social withdrawal Some children feel empowered by presenting a peer awareness program to their classmates 67 110 117 It can be helpful to educate teachers and school staff about typical tics how they fluctuate during the day how they impact the child and how to distinguish tics from naughty behavior By learning to identify tics adults can refrain from asking or expecting a child to stop ticcing 33 117 because tic suppression can be exhausting unpleasant and attention demanding and can result in a subsequent rebound bout of tics 33 Adults with TS may withdraw socially to avoid stigmatization and discrimination because of their tics 118 Depending on their country s healthcare system they may receive social services or help from support groups 119 Behavioral Further information Management of Tourette syndrome Behavioral Behavioral therapies using habit reversal training HRT and exposure and response prevention ERP are first line interventions in the management of Tourette syndrome 20 115 and have been shown to be effective 13 Because tics are somewhat suppressible when people with TS are aware of the premonitory urge that precedes a tic they can be trained to develop a response to the urge that competes with the tic 14 120 Comprehensive behavioral intervention for tics CBIT is based on HRT the best researched behavioral therapy for tics 120 TS experts debate whether increasing a child s awareness of tics with HRT CBIT as opposed to ignoring tics can lead to more tics later in life 120 When disruptive behaviors related to comorbid conditions exist anger control training and parent management training can be effective 4 121 122 CBT is a useful treatment when OCD is present 14 Relaxation techniques such as exercise yoga and meditation may be useful in relieving the stress that can aggravate tics Beyond HRT the majority of behavioral interventions for Tourette s for example relaxation training and biofeedback have not been systematically evaluated and are not empirically supported 123 Medication Further information Management of Tourette syndrome Medication nbsp Clonidine is one of the medications typically tried first when medication is needed for Tourette s 124 Children with tics typically present when their tics are most severe but because the condition waxes and wanes medication is not started immediately or changed often 37 Tics may subside with education reassurance and a supportive environment 2 67 When medication is used the goal is not to eliminate symptoms Instead the lowest dose that manages symptoms without adverse effects is used because adverse effects may be more disturbing than the symptoms being treated with medication 37 The classes of medication with proven efficacy in treating tics typical and atypical neuroleptics can have long term and short term adverse effects 67 Some antihypertensive agents are also used to treat tics studies show variable efficacy but a lower side effect profile than the neuroleptics 13 124 The antihypertensives clonidine and guanfacine are typically tried first in children they can also help with ADHD symptoms 67 124 but there is less evidence that they are effective for adults 2 The neuroleptics risperidone and aripiprazole are tried when antihypertensives are not effective 6 67 and are generally tried first for adults 2 Because of lower side effects aripiprazole is preferred over other antipsychotics 125 The most effective medication for tics is haloperidol but it has a higher risk of side effects 67 Methylphenidate can be used to treat ADHD that co occurs with tics and can be used in combination with clonidine 14 67 Selective serotonin reuptake inhibitors are used to manage anxiety and OCD 14 Other Further information Management of Tourette syndrome Other Complementary and alternative medicine approaches such as dietary modification neurofeedback and allergy testing and control have popular appeal but they have no proven benefit in the management of Tourette syndrome 126 127 Despite this lack of evidence up to two thirds of parents caregivers and individuals with TS use dietary approaches and alternative treatments and do not always inform their physicians 25 110 There is low confidence that tics are reduced with tetrahydrocannabinol 6 and insufficient evidence for other cannabis based medications in the treatment of Tourette s 109 128 There is no good evidence supporting the use of acupuncture or transcranial magnetic stimulation neither is there evidence supporting intravenous immunoglobulin plasma exchange or antibiotics for the treatment of PANDAS 4 Deep brain stimulation DBS has become a valid option for individuals with severe symptoms that do not respond to conventional therapy and management 65 although it is an experimental treatment 129 Selecting candidates who may benefit from DBS is challenging and the appropriate lower age range for surgery is unclear 11 it is potentially useful in less than 3 of individuals 1 The ideal brain location to target has not been identified as of 2019 109 130 Pregnancy A quarter of women report that their tics increase before menstruation however studies have not shown consistent evidence of a change in frequency or severity of tics related to pregnancy 131 132 or hormonal levels 133 Overall symptoms in women respond better to haloperidol than they do for men 131 Most women find they can withdraw from medication during pregnancy without much trouble 134 When needed medications are used at the lowest doses possible 133 During pregnancy neuroleptic medications are avoided when possible because of the risk of pregnancy complications 132 When needed olanzapine risperidone and quetiapine are most often used as they have not been shown to cause fetal abnormalities 132 One report found that haloperidol could be used during pregnancy 134 to minimize the side effects in the mother including low blood pressure and anticholinergic effects 135 although it may cross the placenta 132 If severe tics might interfere with administration of local anesthesia other anesthesia options are considered 132 Neuroleptics in low doses may not affect the breastfed infant but most medications are avoided 132 Clonidine and amphetamines may be present in breast milk 133 Prognosis nbsp Tim Howard described in 2019 by a staff writer for the Los Angeles Times as the greatest goalkeeper in U S soccer history 136 attributes his success in the sport to his Tourette s 137 Tourette syndrome is a spectrum disorder its severity ranges from mild to severe 88 Symptoms typically subside as children pass through adolescence 65 In a group of ten children at the average age of highest tic severity around ten or eleven almost four will see complete remission by adulthood Another four will have minimal or mild tics in adulthood but not complete remission The remaining two will have moderate or severe tics as adults but only rarely will their symptoms in adulthood be more severe than in childhood 39 Regardless of symptom severity individuals with Tourette s have a normal life span 138 Symptoms may be lifelong and chronic for some but the condition is not degenerative or life threatening 138 Intelligence among those with pure TS follows a normal curve although there may be small differences in intelligence in those with comorbid conditions 20 64 The severity of tics early in life does not predict their severity in later life 35 There is no reliable means of predicting the course of symptoms for a particular individual 104 but the prognosis is generally favorable 104 By the age of fourteen to sixteen when the highest tic severity has typically passed a more reliable prognosis might be made 118 Tics may be at their highest severity when they are diagnosed and often improve as an individual s family and friends come to better understand the condition 14 39 Studies report that almost eight out of ten children with Tourette s experience a reduction in the severity of their tics by adulthood 14 39 and some adults who still have tics may not be aware that they have them A study that used video to record tics in adults found that nine out of ten adults still had tics and half of the adults who considered themselves tic free displayed evidence of mild tics 14 139 Quality of life People with Tourette s are affected by the consequences of tics and by the efforts to suppress them 140 Head and eye tics can interfere with reading or lead to headaches and forceful tics can lead to repetitive strain injury 141 Severe tics can lead to pain or injuries as an example a rare cervical disc herniation was reported from a neck tic 47 67 Some people may learn to camouflage socially inappropriate tics or channel the energy of their tics into a functional endeavor 36 A supportive family and environment generally give those with Tourette s the skills to manage the disorder 140 142 143 Outcomes in adulthood are associated more with the perceived significance of having tics as a child than with the actual severity of the tics A person who was misunderstood punished or teased at home or at school is likely to fare worse than a child who enjoyed an understanding environment 36 The long lasting effects of bullying and teasing can influence self esteem self confidence and even employment choices and opportunities 140 144 Comorbid ADHD can severely affect the child s well being in all realms and extend into adulthood 140 Factors impacting quality of life change over time given the natural fluctuating course of tic disorders the development of coping strategies and a person s age As ADHD symptoms improve with maturity adults report less negative impact in their occupational lives than do children in their educational lives 140 Tics have a greater impact on adults psychosocial function including financial burdens than they do on children 118 Adults are more likely to report a reduced quality of life due to depression or anxiety 140 depression contributes a greater burden than tics to adults quality of life compared to children 118 As coping strategies become more effective with age the impact of OCD symptoms seems to diminish 140 EpidemiologyTourette syndrome is a common but underdiagnosed condition 5 that reaches across all social racial and ethnic groups 4 31 35 145 It is three to four times more frequent in males than in females 61 Observed prevalence rates are higher among children than adults because tics tend to remit or subside with maturity and a diagnosis may no longer be warranted for many adults 38 Up to 1 of the overall population experiences tic disorders including chronic tics and transient provisional or unspecified tics in childhood 54 Chronic tics affect 5 of children and transient tics affect up to 20 61 122 Many individuals with tics do not know they have tics 20 or do not seek a diagnosis so epidemiological studies of TS reflect a strong ascertainment bias towards those with co occurring conditions 51 The reported prevalence of TS varies according to the source age and sex of the sample the ascertainment procedures and diagnostic system 31 with a range reported between 0 15 and 3 0 for children and adolescents 61 Sukhodolsky et al wrote in 2017 that the best estimate of TS prevalence in children was 1 4 61 Both Robertson 41 and Stern state that the prevalence in children is 1 2 The prevalence of TS in the general population is estimated as 0 3 to 1 0 5 According to turn of the century census data these prevalence estimates translated to half a million children in the US with TS and half a million people in the UK with TS although symptoms in many older individuals would be almost unrecognizable e Tourette syndrome was once thought to be rare in 1972 the US National Institutes of Health NIH believed there were fewer than 100 cases in the United States 146 and a 1973 registry reported only 485 cases worldwide 147 However numerous studies published since 2000 have consistently demonstrated that the prevalence is much higher 148 Recognizing that tics may often be undiagnosed and hard to detect f newer studies use direct classroom observation and multiple informants parents teachers and trained observers and therefore record more cases than older studies 111 151 As the diagnostic threshold and assessment methodology have moved towards recognition of milder cases the estimated prevalence has increased 148 Because of the high male prevalence of TS there is limited data on females from which conclusion about gender based differences can be drawn caution may be warranted in extending conclusions to females regarding the characteristics and treatment of tics based on studies of mostly males 46 A 2021 review stated that females may see a later peak than males in symptoms with less remission over time along with a higher prevalence of anxiety and mood disorders 46 HistoryMain article History of Tourette syndrome nbsp Jean Martin Charcot was a French neurologist and professor who named Tourette syndrome for his intern Georges Gilles de la Tourette In A Clinical Lesson at the Salpetriere 1887 Andre Brouillet portrays a medical lecture by Charcot the central standing figure and shows de la Tourette in the audience seated in the first row wearing an apron A French doctor Jean Marc Gaspard Itard reported the first case of Tourette syndrome in 1825 152 describing the Marquise de Dampierre an important woman of nobility in her time 153 154 In 1884 Jean Martin Charcot an influential French physician assigned his student 155 and intern Georges Gilles de la Tourette to study patients with movement disorders at the Salpetriere Hospital with the goal of defining a condition distinct from hysteria and chorea 156 In 1885 Gilles de la Tourette published an account in Study of a Nervous Affliction of nine people with convulsive tic disorder concluding that a new clinical category should be defined 157 158 The eponym was bestowed by Charcot after and on behalf of Gilles de la Tourette who later became Charcot s senior resident 34 159 Following the 19th century descriptions a psychogenic view prevailed and little progress was made in explaining or treating tics until well into the 20th century 34 The possibility that movement disorders including Tourette syndrome might have an organic origin was raised when an encephalitis lethargica epidemic from 1918 to 1926 was linked to an increase in tic disorders 34 160 During the 1960s and 1970s as the beneficial effects of haloperidol on tics became known the psychoanalytic approach to Tourette syndrome was questioned 96 161 The turning point came in 1965 when Arthur K Shapiro described as the father of modern tic disorder research 162 used haloperidol to treat a person with Tourette s and published a paper criticizing the psychoanalytic approach 160 In 1975 The New York Times headlined an article with Bizarre outbursts of Tourette s disease victims linked to chemical disorder in brain and Shapiro said The bizarre symptoms of this illness are rivaled only by the bizarre treatments used to treat it 163 During the 1990s a more neutral view of Tourette s emerged in which a genetic predisposition is seen to interact with non genetic and environmental factors 34 164 165 The fourth revision of the DSM DSM IV in 1994 added a diagnostic requirement for marked distress or significant impairment in social occupational or other important areas of functioning which led to an outcry from TS experts and researchers who noted that many people were not even aware they had TS nor were they distressed by their tics clinicians and researchers resorted to using the older criteria in research and practice 7 In 2000 the American Psychiatric Association revised its diagnostic criteria in the fourth text revision of the DSM DSM IV TR to remove the impairment requirement 84 recognizing that clinicians often see people who have Tourette s without distress or impairment 90 Society and cultureMain article Societal and cultural aspects of Tourette syndrome nbsp Samuel Johnson c 1772 Johnson is likely to have had Tourette syndrome Not everyone with Tourette s wants treatment or a cure especially if that means they may lose something else in the process 114 166 The researchers Leckman and Cohen believe that there may be latent advantages associated with an individual s genetic vulnerability to developing Tourette syndrome that may have adaptive value such as heightened awareness and increased attention to detail and surroundings 167 168 Accomplished musicians athletes public speakers and professionals from all walks of life are found among people with Tourette s 89 169 The athlete Tim Howard described by the Chicago Tribune as the rarest of creatures an American soccer hero 170 and by the Tourette Syndrome Association as the most notable individual with Tourette Syndrome around the world 171 says that his neurological makeup gave him an enhanced perception and an acute focus that contributed to his success on the field 137 Samuel Johnson is a historical figure who likely had Tourette syndrome as evidenced by the writings of his friend James Boswell 172 173 Johnson wrote A Dictionary of the English Language in 1747 and was a prolific writer poet and critic There is little support 174 175 for speculation that Mozart had Tourette s 176 the potentially coprolalic aspect of vocal tics is not transferred to writing so Mozart s scatological writings are not relevant the composer s available medical history is not thorough the side effects of other conditions may be misinterpreted and the evidence of motor tics in Mozart s life is doubtful 177 Likely portrayals of TS or tic disorders in fiction predating Gilles de la Tourette s work are Mr Pancks in Charles Dickens s Little Dorrit and Nikolai Levin in Leo Tolstoy s Anna Karenina 178 The entertainment industry has been criticized for depicting those with Tourette syndrome as social misfits whose only tic is coprolalia which has furthered the public s misunderstanding and stigmatization of those with Tourette s 179 180 181 The coprolalic symptoms of Tourette s are also fodder for radio and television talk shows in the US 182 and for the British media 183 High profile media coverage focuses on treatments that do not have established safety or efficacy such as deep brain stimulation and alternative therapies involving unstudied efficacy and side effects are pursued by many parents 184 Research directionsFurther information History of Tourette syndrome Research directions and controversies Research since 1999 has advanced knowledge of Tourette s in the areas of genetics neuroimaging neurophysiology and neuropathology but questions remain about how best to classify it and how closely it is related to other movement or psychiatric disorders 4 13 14 15 Modeled after genetic breakthroughs seen with large scale efforts in other neurodevelopmental disorders three groups are collaborating in research of the genetics of Tourette s The Tourette Syndrome Association International Consortium for Genetics TSAICG Tourette International Collaborative Genetics Study TIC Genetics European Multicentre Tics in Children Studies EMTICS Compared to the progress made in gene discovery in certain neurodevelopmental or mental health disorders autism schizophrenia and bipolar disorder the scale of related TS research is lagging in the United States due to funding 185 Notes According to Dale 2017 over time 15 of people with tics have only TS 85 of people with Tourette s will develop a co occurring condition 14 In a 2017 literature review Sukhodolsky et al stated that 37 of individuals in clinical samples had pure TS 61 Denckla 2006 reported that a review of patient records revealed that about 40 of people with Tourette s have TS only 62 63 Dure and DeWolfe 2006 reported that 57 of 656 individuals presenting with tic disorders had tics uncomplicated by other conditions 23 There were no changes in the fifth text revision of 2022 DSM 5 TR 83 The YGTSS is considered the gold standard in tic assessment 5 Movement disorders without an organic cause have been referred to over time using terms such as hysterical psychogenic and psychogenic movement disorders 99 100 DSM 5 classifies them under functional neurological symptom disorder conversion disorder 101 A prevalence range of 0 1 to 1 yields an estimate of 53 000 to 530 000 school age children with Tourette s in the United States using 2000 census data 54 In the United Kingdom a prevalence estimate of 1 0 based on the 2001 census meant that about half a million people aged five or older would have Tourette s although symptoms in older individuals would be almost unrecognizable 42 Prevalence rates in special education populations are higher 41 The discrepancy between current and prior prevalence estimates arises from several factors the ascertainment bias caused by samples that were drawn from clinically referred cases assessment methods that failed to detect milder cases and the use of different diagnostic criteria and thresholds 148 There were few broad based community studies published before 2000 and most older epidemiological studies were based only on individuals referred to tertiary care or specialty clinics 51 149 People with mild symptoms may not have sought treatment and physicians may have avoided an official diagnosis of TS in children due to concerns about stigmatization 43 Studies are vulnerable to further error because tics vary in intensity and expression are often intermittent and are not always recognized by clinicians individuals with TS family members friends or teachers 37 150 References a b c Muller Vahl KR Szejko N Verdellen C et al July 2021 European clinical guidelines for Tourette syndrome and other tic disorders summary statement Eur Child Adolesc Psychiatry 31 3 377 382 doi 10 1007 s00787 021 01832 4 PMC 8940881 PMID 34244849 S2CID 235781456 a b c d e f g h i j k l m n o p q r s t u v w x y z aa Stern JS August 2018 Tourette s syndrome and its borderland PDF Pract Neurol 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Association Retrieved from April 7 2005 archive org version on December 30 2011 Pearce JM July 1994 Doctor Samuel Johnson the great convulsionary a victim of Gilles de la Tourette s syndrome J R Soc Med Historical biography 87 7 396 399 doi 10 1177 014107689408700709 PMC 1294650 PMID 8046726 Powell H Kushner HI 2015 Mozart at play the limitations of attributing the etiology of genius to tourette syndrome and mental illness Prog Brain Res Historical biography 216 277 291 doi 10 1016 bs pbr 2014 11 010 PMID 25684294 Bhattacharyya KB Rai S 2015 Famous people with Tourette s syndrome Dr Samuel Johnson yes amp Wolfgang Amadeus Mozart may be Victims of Tourette s syndrome Ann Indian Acad Neurol 18 2 157 161 doi 10 4103 0972 2327 145288 PMC 4445189 PMID 26019411 Simkin B 1992 Mozart s scatological disorder BMJ Historical biography 305 6868 1563 1567 doi 10 1136 bmj 305 6868 1563 PMC 1884718 PMID 1286388 Also see Simkin Benjamin Medical and musical byways of Mozartiana Fithian Press 2001 ISBN 1 56474 349 7 Review Archived December 7 2005 at the Wayback Machine Retrieved on May 14 2007 Mozart Kammer T 2007 Mozart in the neurological department who has the tic PDF In Bogousslavsky J Hennerici MG eds Neurological Disorders in Famous Artists Part 2 Historical biography Frontiers of Neurology and Neuroscience Vol 22 Basel Karger pp 184 192 doi 10 1159 000102880 ISBN 978 3 8055 8265 0 PMID 17495512 Archived from the original PDF on February 7 2012 Ashoori A Jankovic J November 2007 Mozart s movements and behaviour a case of Tourette s syndrome J Neurol Neurosurg Psychiatry Historical biography 78 11 1171 1175 doi 10 1136 jnnp 2007 114520 PMC 2117611 PMID 17940168 Sacks O 1992 Tourette s syndrome and creativity BMJ Editorial comment 305 6868 1515 1516 doi 10 1136 bmj 305 6868 1515 PMC 1884721 PMID 1286364 Voss H October 2012 The representation of movement disorders in fictional literature J Neurol Neurosurg Psychiatry Review 83 10 994 999 doi 10 1136 jnnp 2012 302716 PMID 22752692 S2CID 27902880 Calder Sprackman S Sutherland S Doja A March 2014 Tourette syndrome in film and television The Canadian Journal of Neurological Sciences 41 2 226 232 doi 10 1017 S0317167100016620 PMID 24534035 S2CID 39288755 Lim Fat MJ Sell E Barrowman N Doja A 2012 Public perception of Tourette syndrome on YouTube Journal of Child Neurology 27 8 1011 1016 CiteSeerX 10 1 1 997 9069 doi 10 1177 0883073811432294 PMID 22821136 S2CID 21648806 Holtgren B January 11 2006 Truth about Tourette s not what you think Cincinnati Enquirer As medical problems go Tourette s is except in the most severe cases about the most minor imaginable thing to have the freak show image unfortunately still prevails overwhelmingly The blame for the warped perceptions lies overwhelmingly with the video media the Internet movies and TV If you search for Tourette on Google or YouTube you ll get a gazillion hits that almost invariably show the most outrageously extreme examples of motor and vocal tics Television with notable exceptions such as Oprah has sensationalized Tourette s so badly for so long that it seems beyond hope that most people will ever know the more prosaic truth US media Oprah and Dr Laura Press release Tourette Syndrome Association May 31 2001 Archived from the original on October 6 2001 Retrieved December 21 2011 Letter of response to Dr Phil Press release Tourette Syndrome Association Archived from the original on August 31 2008 Retrieved December 21 2011 Letter of response to Garrison Keillor radio show Press release Tourette Syndrome Association Archived from the original on February 7 2009 Retrieved December 21 2011 Guldberg H May 26 2006 Stop celebrating Tourette s Spiked Archived from the original on March 14 2017 Retrieved December 26 2006 Swerdlow NR September 2005 Tourette syndrome current controversies and the battlefield landscape Curr Neurol Neurosci Rep 5 5 329 331 doi 10 1007 s11910 005 0054 8 PMID 16131414 S2CID 26342334 Fernandez TV State MW Pittenger C 2018 Tourette disorder and other tic disorders Neurogenetics Part I Review Handbook of Clinical Neurology Vol 147 pp 343 354 doi 10 1016 B978 0 444 63233 3 00023 3 ISBN 978 0 444 63233 3 PMID 29325623 Regardless of whether the focus is on discovering rare or common sequence or structural genetic variation it is clear that large collections of biomaterials likely in the tens of thousands that are accessible by multiple research groups will be essential for success Three consortia are now beginning to work toward this goal TSAICG and TIC Genetics in the United States and EMTics in the European Union there is active collaboration among these groups which will also be essential for success However the scale of the funded collection efforts particularly in the United States remains quite modest compared to other neuropsychiatric disorders in which there has been success in gene discovery Book sources Abi Jaoude E Kideckel D Stephens R et al 2009 Tourette syndrome a model of integration In Carlstedt RA ed Handbook of Integrative Clinical Psychology Psychiatry and Behavioral Medicine Perspectives Practices and Research New York Springer Publishing Company ISBN 978 0 8261 1095 4 Cohen DJ Jankovic J Goetz CG eds 2001 Tourette Syndrome Advances in Neurology Vol 85 Philadelphia PA Lippincott Williams amp Wilkins ISBN 0 7817 2405 8 Kushner HI 2000 A Cursing Brain The Histories of Tourette Syndrome Harvard University Press ISBN 0 674 00386 1 Leckman JF Cohen DJ 1999 Tourette s Syndrome Tics Obsessions Compulsions Developmental Psychopathology and Clinical Care New York John Wiley amp Sons Inc ISBN 978 0471160373 Martino D Leckman JF eds 2013 Tourette syndrome Oxford University Press ISBN 978 0199796267 Bloch MH 2013 Clinical course and adult outcome in Tourette syndrome In Martino D Leckman JF eds Tourette syndrome Oxford University Press pp 107 120 Muller Vahl KR 2013 Information and social support for patients and families In Martino D Leckman JF eds Tourette syndrome Oxford University Press pp 623 635 Pruitt SK Packer LE 2013 Tourette syndrome In Martino D Leckman JF eds Information and support for educators Oxford University Press pp 636 655 Sukhodolsky DG Gladstone TR Kaushal SA Piasecka JB Leckman JF 2017 Tics and Tourette Syndrome In Matson JL ed Handbook of Childhood Psychopathology and Developmental Disabilities Treatment Autism and Child Psychopathology Series Springer pp 241 256 doi 10 1007 978 3 319 71210 9 14 ISBN 978 3 319 71209 3 Walkup JT Mink JW Hollenback PJ eds 2006 Advances in Neurology Tourette Syndrome Vol 99 Philadelphia PA Lippincott Williams amp Wilkins ISBN 0 7817 9970 8 Walusinski O 2019 Georges Gilles de la Tourette Beyond the Eponym a Biography Oxford University Press ISBN 978 0 19 063603 6 Further readingMcGuire JF Murphy TK Piacentini J Storch EA 2018 The Clinician s Guide to Treatment and Management of Youth with Tourette Syndrome and Tic Disorders Academic Press ISBN 978 0128119808 Olson S September 2004 Neurobiology Making sense of Tourette s Science 305 5689 1390 92 doi 10 1126 science 305 5689 1390 PMID 15353772 S2CID 177963554 External links nbsp Wikimedia Commons has media related to Tourette syndrome Tourette syndrome at Curlie Retrieved from https en wikipedia org w index php title Tourette syndrome amp oldid 1220418288, wikipedia, wiki, book, books, library,

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