fbpx
Wikipedia

Brian Kobilka

February 15, 2024

Brian Kent Kobilka (born May 30, 1955)[1] is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the workings of G protein-coupled receptors. He is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine. He is also a co-founder of ConfometRx, a biotechnology company focusing on G protein-coupled receptors. He was named a member of the National Academy of Sciences in 2011.

Brian Kobilka
Born
Brian Kent Kobilka

(1955-05-30) May 30, 1955 (age 68)
Little Falls, Minnesota, United States
NationalityAmerican
Alma materUniversity of Minnesota Duluth (BS)
Yale University (MD)
AwardsNobel Prize in Chemistry (2012)
Scientific career
FieldsCrystallography
InstitutionsStanford University, Duke University
Academic advisorsRobert Lefkowitz

Early life edit

Kobilka attended St. Mary's Grade School in Little Falls, Minnesota, a part of the Roman Catholic Diocese of Saint Cloud.[2] He then graduated from Little Falls High School. He received a Bachelor’s Degree in Biology and Chemistry from the University of Minnesota Duluth, and earned his M.D., cum laude, from Yale University School of Medicine. Following the completion of his residency in internal medicine at Washington University in St. Louis School of Medicine's Barnes-Jewish Hospital. Kobilka worked in research as a postdoctoral fellow under Robert Lefkowitz at Duke University, where he started work on cloning the β2-adrenergic receptor. Kobilka moved to Stanford in 1989.[3] He was a Howard Hughes Medical Institute (HHMI) investigator from 1987 to 2003.[4]

Research edit

 
Kobilka in Stockholm 2012

Kobilka is best known for his research on the structure and activity of G protein-coupled receptors (GPCRs); in particular, work from Kobilka's laboratory determined the molecular structure of the β2-adrenergic receptor.[5][6][7][8] This work has been highly cited by other scientists because GPCRs are important targets for pharmaceutical therapeutics, but notoriously difficult to work with in X-ray crystallography.[9] Before, rhodopsin was the only G-protein coupled receptor where the structure had been determined at high resolution. The β2-adrenergic receptor structure was soon followed by the determination of the molecular structure of several other G-protein coupled receptors.[10]

Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" award from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute of Neurological Disorders and Stroke.[14] He received the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for his work on G protein-coupled receptors.[15][16] In 2017, Kobilka received the Golden Plate Award of the American Academy of Achievement.[17]

As part of Shenzhen’s 13th Five-Year Plan funding research in emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he opened the Kobilka Institute of Innovative Drug Discovery at the CUHK Shenzhen campus in Southern China.[19]

Personal life edit

Kobilka is from Little Falls in central Minnesota. Both his grandfather Felix J. Kobilka (1893–1991) and his father Franklyn A. Kobilka (1921–2004) were bakers and natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged to the Medved and Kiewel families of Prussian immigrants, who from 1888 owned the historical Kiewel brewery in Little Falls. His mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met his wife Tong Sun Thian, a Malaysian-Chinese woman,[23] at the University of Minnesota Duluth. They have two children, Jason and Megan Kobilka.[20][24]

References edit

  1. ^ "BRIAN K. KOBILKA, MD". Tsinghua University School of Medicine. Archived from the original on 2012-12-16. Retrieved 2013-01-16.
  2. ^ "Catholic scientist at Stanford shares Nobel Prize for work in chemistry". Catholic News Service. 2012-10-23. Archived from the original on 2013-02-15. Retrieved 2013-01-19.
  3. ^ Nature Reviews Drug Discovery GPCR Questionnaire Participants (2004). "The state of GPCR research in 2004 : Nature Reviews Drug Discovery". Nature Reviews Drug Discovery. Nature. 3 (7): 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092. Retrieved 2013-01-19.
  4. ^ HHMI. Archived from the original on 2014-05-02. Retrieved 2013-01-19.
  5. ^ . Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
  6. ^ Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007). "Crystal structure of the human β2-adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode:2007Natur.450..383R. doi:10.1038/nature06325. PMID 17952055. S2CID 4407117.
  7. ^ Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007). "High Resolution Crystal Structure of an Engineered Human β2-Adrenergic G protein-Coupled Receptor". Science. 318 (5854): 1258–65. Bibcode:2007Sci...318.1258C. doi:10.1126/science.1150577. PMC 2583103. PMID 17962520.
  8. ^ Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007). "GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function". Science. 318 (5854): 1266–73. Bibcode:2007Sci...318.1266R. doi:10.1126/science.1150609. PMID 17962519. S2CID 1559802.
  9. ^ ScienceWatch.com:. Archived from the original on 2010-05-08. Retrieved 2008-10-16.
  10. ^ Hanson, M. A.; Stevens, R. C. (2009). "Discovery of New GPCR Biology: One Receptor Structure at a Time". Structure. 17 (1): 8–14. doi:10.1016/j.str.2008.12.003. PMC 2813843. PMID 19141277.
  11. ^ "John J. Abel Award". ASPET. Retrieved 2013-01-24.
  12. ^ "Kobilka's work recognized in magazine award". Stanford University. 2008-01-09. Retrieved 2013-01-24.
  13. ^ . National Institute of Neurological Disorders and Stroke (NINDS). 2004-11-10. Archived from the original on 2008-10-07. Retrieved 2013-01-24.
  14. ^ . National Institute of Neurological Disorders and Stroke (NINDS). 2007-12-05. Archived from the original on 2008-10-01. Retrieved 2013-01-24.
  15. ^ Hotz, Robert Lee (October 10, 2012). "U.S. Scientists Win Chemistry Nobel". The Wall Street Journal Online. Retrieved October 10, 2012.
  16. ^ "Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Prize in chemistry". Daily News. AP. 10 October 2012. Retrieved 11 October 2012.
  17. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  18. ^ "Shenzhen Has 7 Nobel Prize Winners' Labs, 3 More Planned". That's Online. Retrieved 2021-03-15.
  19. ^ "KOBILKA INSTITUTE OF INNOVATIVE DRUG DISCOVERY | CUHK-Shenzhen". lhs.cuhk.edu.cn. Retrieved 2021-03-15.
  20. ^ a b "Franklyn A. Kobilka, 83". ECM Publishers, Inc. 2004-03-16. Archived from the original on 2012-12-09. Retrieved 2013-01-16.
  21. ^ Paul Walsh; Alejandra Matos (2012-10-11). "Little Falls bakery helps deliver a sweet reward: Nobel Prize". StarTribune. Retrieved 2013-01-16.
  22. ^ . Archived from the original on 2012-12-06. Retrieved 2012-10-10.
  23. ^ (in Chinese). 星洲日報. 2012-10-11. Archived from the original on 2012-12-19. Retrieved 2013-01-16.
  24. ^ Buchen, Lizzie (24 August 2011). "Cell signalling: It's all about the structure". Nature. 476 (7361): 387–390. Bibcode:2011Natur.476..387B. doi:10.1038/476387a. PMID 21866135.

Publications edit

  • Bokoch, Michael P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor". Nature. 463 (1): 108–112. Bibcode:2010Natur.463..108B. doi:10.1038/nature08650. OSTI 1002248. PMC 2805469. PMID 20054398.
  • Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Structure of the β2 Adrenergic Receptor—Gs Protein Complex". Nature. 477 (9): 549–555. Bibcode:2011Natur.477..549R. doi:10.1038/nature10361. OSTI 1026537. PMC 3184188. PMID 21772288.
  • Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist". Nature. 482 (2): 547–551. Bibcode:2012Natur.482..547H. doi:10.1038/nature10753. OSTI 1035713. PMC 3345277. PMID 22278061.
  • Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal structure of the µ-opioid receptor bound to a morphinan antagonist". Nature. 485 (7398): 321–326. Bibcode:2012Natur.485..321M. doi:10.1038/nature10954. OSTI 1043732. PMC 3523197. PMID 22437502.

External links edit

  • Kobilka laboratory home page
  • Brian Kobilka academic profile 2012-10-14 at the Wayback Machine
  • ConfometRx home page
  • Brian Kobilka on Nobelprize.org  

February 15, 2024
brian, kobilka, brian, kent, kobilka, born, 1955, american, physiologist, recipient, 2012, nobel, prize, chemistry, with, robert, lefkowitz, discoveries, that, reveal, workings, protein, coupled, receptors, currently, professor, department, molecular, cellular. Brian Kent Kobilka born May 30 1955 1 is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the workings of G protein coupled receptors He is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine He is also a co founder of ConfometRx a biotechnology company focusing on G protein coupled receptors He was named a member of the National Academy of Sciences in 2011 Brian KobilkaBornBrian Kent Kobilka 1955 05 30 May 30 1955 age 68 Little Falls Minnesota United StatesNationalityAmericanAlma materUniversity of Minnesota Duluth BS Yale University MD AwardsNobel Prize in Chemistry 2012 Scientific careerFieldsCrystallographyInstitutionsStanford University Duke UniversityAcademic advisorsRobert Lefkowitz Contents 1 Early life 2 Research 3 Personal life 4 References 5 Publications 6 External linksEarly life editKobilka attended St Mary s Grade School in Little Falls Minnesota a part of the Roman Catholic Diocese of Saint Cloud 2 He then graduated from Little Falls High School He received a Bachelor s Degree in Biology and Chemistry from the University of Minnesota Duluth and earned his M D cum laude from Yale University School of Medicine Following the completion of his residency in internal medicine at Washington University in St Louis School of Medicine s Barnes Jewish Hospital Kobilka worked in research as a postdoctoral fellow under Robert Lefkowitz at Duke University where he started work on cloning the b2 adrenergic receptor Kobilka moved to Stanford in 1989 3 He was a Howard Hughes Medical Institute HHMI investigator from 1987 to 2003 4 Research edit nbsp Kobilka in Stockholm 2012Kobilka is best known for his research on the structure and activity of G protein coupled receptors GPCRs in particular work from Kobilka s laboratory determined the molecular structure of the b2 adrenergic receptor 5 6 7 8 This work has been highly cited by other scientists because GPCRs are important targets for pharmaceutical therapeutics but notoriously difficult to work with in X ray crystallography 9 Before rhodopsin was the only G protein coupled receptor where the structure had been determined at high resolution The b2 adrenergic receptor structure was soon followed by the determination of the molecular structure of several other G protein coupled receptors 10 Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J Abel Award in Pharmacology 11 His GPCR structure work was named runner up for the 2007 Breakthrough of the Year award from Science 12 The work was in part supported by Kobilka s 2004 Javits Neuroscience Investigator Award 13 from the National Institute of Neurological Disorders and Stroke 14 He received the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for his work on G protein coupled receptors 15 16 In 2017 Kobilka received the Golden Plate Award of the American Academy of Achievement 17 As part of Shenzhen s 13th Five Year Plan funding research in emerging technologies and opening Nobel laureate research labs 18 in 2017 he opened the Kobilka Institute of Innovative Drug Discovery at the CUHK Shenzhen campus in Southern China 19 Personal life editKobilka is from Little Falls in central Minnesota Both his grandfather Felix J Kobilka 1893 1991 and his father Franklyn A Kobilka 1921 2004 were bakers and natives of Little Falls Minnesota 20 21 22 Kobilka s grandmother Isabelle Susan Kobilka nee Medved 1891 1980 belonged to the Medved and Kiewel families of Prussian immigrants who from 1888 owned the historical Kiewel brewery in Little Falls His mother is Betty L Kobilka nee Faust b 1930 Kobilka met his wife Tong Sun Thian a Malaysian Chinese woman 23 at the University of Minnesota Duluth They have two children Jason and Megan Kobilka 20 24 References edit BRIAN K KOBILKA MD Tsinghua University School of Medicine Archived from the original on 2012 12 16 Retrieved 2013 01 16 Catholic scientist at Stanford shares Nobel Prize for work in chemistry Catholic News Service 2012 10 23 Archived from the original on 2013 02 15 Retrieved 2013 01 19 Nature Reviews Drug Discovery GPCR Questionnaire Participants 2004 The state of GPCR research in 2004 Nature Reviews Drug Discovery Nature Reviews Drug Discovery Nature 3 7 577 626 doi 10 1038 nrd1458 PMID 15272499 S2CID 33620092 Retrieved 2013 01 19 Brian K Kobilka M D HHMI Archived from the original on 2014 05 02 Retrieved 2013 01 19 Cell Insights Could Bring Better Drugs Forbes Archived from the original on 2011 02 15 Retrieved 2013 01 23 Rasmussen SG Choi HJ Rosenbaum DM Kobilka TS Thian FS Edwards PC Burghammer M Ratnala VR Sanishvili R Fischetti RF Schertler GF Weis WI Kobilka BK 2007 Crystal structure of the human b2 adrenergic G protein coupled receptor Nature 450 7168 383 7 Bibcode 2007Natur 450 383R doi 10 1038 nature06325 PMID 17952055 S2CID 4407117 Cherezov V Rosenbaum DM Hanson MA Rasmussen SG Thian FS Kobilka TS Choi HJ Kuhn P Weis WI Kobilka BK Stevens RC 2007 High Resolution Crystal Structure of an Engineered Human b2 Adrenergic G protein Coupled Receptor Science 318 5854 1258 65 Bibcode 2007Sci 318 1258C doi 10 1126 science 1150577 PMC 2583103 PMID 17962520 Rosenbaum DM Cherezov V Hanson MA Rasmussen SG Thian FS Kobilka TS Choi HJ Yao XJ Weis WI Stevens RC Kobilka BK 2007 GPCR engineering yields high resolution structural insights into b2 adrenergic receptor function Science 318 5854 1266 73 Bibcode 2007Sci 318 1266R doi 10 1126 science 1150609 PMID 17962519 S2CID 1559802 ScienceWatch com Interview with Brian Kobilka Archived from the original on 2010 05 08 Retrieved 2008 10 16 Hanson M A Stevens R C 2009 Discovery of New GPCR Biology One Receptor Structure at a Time Structure 17 1 8 14 doi 10 1016 j str 2008 12 003 PMC 2813843 PMID 19141277 John J Abel Award ASPET Retrieved 2013 01 24 Kobilka s work recognized in magazine award Stanford University 2008 01 09 Retrieved 2013 01 24 Javits Neuroscience Investigator Award Recognizes Eight Exemplary Scientists National Institute of Neurological Disorders and Stroke NINDS 2004 11 10 Archived from the original on 2008 10 07 Retrieved 2013 01 24 The Structure of an Important Drug Target Made Crystal Clear National Institute of Neurological Disorders and Stroke NINDS 2007 12 05 Archived from the original on 2008 10 01 Retrieved 2013 01 24 Hotz Robert Lee October 10 2012 U S Scientists Win Chemistry Nobel The Wall Street Journal Online Retrieved October 10 2012 Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Prize in chemistry Daily News AP 10 October 2012 Retrieved 11 October 2012 Golden Plate Awardees of the American Academy of Achievement www achievement org American Academy of Achievement Shenzhen Has 7 Nobel Prize Winners Labs 3 More Planned That s Online Retrieved 2021 03 15 KOBILKA INSTITUTE OF INNOVATIVE DRUG DISCOVERY CUHK Shenzhen lhs cuhk edu cn Retrieved 2021 03 15 a b Franklyn A Kobilka 83 ECM Publishers Inc 2004 03 16 Archived from the original on 2012 12 09 Retrieved 2013 01 16 Paul Walsh Alejandra Matos 2012 10 11 Little Falls bakery helps deliver a sweet reward Nobel Prize StarTribune Retrieved 2013 01 16 Social Security Death Index Archived from the original on 2012 12 06 Retrieved 2012 10 10 大馬華人女婿獲諾獎 化學獎得主科比爾卡會煮豉油雞 in Chinese 星洲日報 2012 10 11 Archived from the original on 2012 12 19 Retrieved 2013 01 16 Buchen Lizzie 24 August 2011 Cell signalling It s all about the structure Nature 476 7361 387 390 Bibcode 2011Natur 476 387B doi 10 1038 476387a PMID 21866135 Publications editBokoch Michael P Zou Yaozhong Rasmussen Soren G F Kobilka Brian K et al 2010 Ligand specific regulation of the extracellular surface of a G protein coupled receptor Nature 463 1 108 112 Bibcode 2010Natur 463 108B doi 10 1038 nature08650 OSTI 1002248 PMC 2805469 PMID 20054398 Rasmussen Soren G F DeVree Brian T Zou Yaozhong Kobilka Tong Sun Kobilka Brian K et al 2011 Crystal Structure of the b2 Adrenergic Receptor Gs Protein Complex Nature 477 9 549 555 Bibcode 2011Natur 477 549R doi 10 1038 nature10361 OSTI 1026537 PMC 3184188 PMID 21772288 Haga Kazuko Kruse Andrew C Asada Hidetsugu Kobilka Brian K et al 2012 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist Nature 482 2 547 551 Bibcode 2012Natur 482 547H doi 10 1038 nature10753 OSTI 1035713 PMC 3345277 PMID 22278061 Manglik Aashish Kruse Andrew C Kobilka Tong Sun Kobilka Brian K et al 2012 Crystal structure of the µ opioid receptor bound to a morphinan antagonist Nature 485 7398 321 326 Bibcode 2012Natur 485 321M doi 10 1038 nature10954 OSTI 1043732 PMC 3523197 PMID 22437502 External links editKobilka laboratory home page Brian Kobilka academic profile Archived 2012 10 14 at the Wayback Machine ConfometRx home page Brian Kobilka on Nobelprize org nbsp AwardsPreceded byDan Shechtman Nobel Prize in Chemistry laureate2012 With Robert Lefkowitz Succeeded byMichael LevittMartin KarplusArieh Warshel Retrieved from https en wikipedia org w index php title Brian Kobilka amp oldid 1206107621, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.