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Amgen

December 04, 2023

Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California.[3][4] One of the world's largest independent biotechnology companies, Amgen's Thousand Oaks staff in 2022 numbered approximately 5,000[5] (8.5% of total city employment)[6] and included hundreds of scientists, making Amgen the largest employer in Ventura County.[7][8] As of 2022, Amgen has approximately 24,000 staff in total.[9]

Amgen Inc.
Headquarters in Thousand Oaks, California
FormerlyApplied Molecular Genetics (1980–1983)
TypePublic
ISINUS0311621009
IndustryBiotechnology
FoundedApril 8, 1980; 43 years ago (1980-04-08)
HeadquartersThousand Oaks, California, U.S.
Key people
Robert A. Bradway
(Chairman, President & CEO)
ProductsAimovig, Aranesp, Blincyto, Epogen, Kineret, Enbrel, Kyprolis, Neulasta, Neupogen, Nplate, Parsabiv, Prolia, Repatha, Sensipar/Mimpara, Vectibix, Xgeva
Revenue US$26.32 billion (2022)
US$9.57 billion (2022)
US$6.55 billion (2022)
Total assets US$65.12 billion (2022)
Total equity US$3.66 billion (2022)
Number of employees
c. 25,200 (December 2022)
Websiteamgen.com
Footnotes / references
[1][2]

In 2019, the company's largest selling products were Enbrel (etanercept),[10] a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases, and Neulasta (pegfilgrastim), an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy.[11] Other marketed products include Evenity (romosozumab-aqqg), Otezla (apremilast), Prolia (denosumab), Repatha (evolocumab), and Lumakras (sotorasib).

History edit

 
AMGen corporate logo, 1983
 
Argentine president Mauricio Macri meets with heads of Amgen, in 2018.

Amgen was established in Thousand Oaks in 1980.[12][7] The name "AMGen" is a portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with its initial public offering). The company's first chief executive officer, from 1980, was co-founder George B. Rathmann, followed by Gordon M. Binder in 1988,[13] followed by Kevin W. Sharer in 2000.[14] Robert A. Bradway became Amgen's president and chief executive officer in May 2012 following Sharer's retirement.[15] Amgen sponsored the Tour of California from 2011 to 2017.[16]

Timeline edit

  • 1980: Founded in Thousand Oaks, California, as Applied Molecular Genetics, Amgen was backed by a small group of venture capitalists. Its focus in early days was on recombinant DNA technology and recombinant human insulin.[17] William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Norman Davidson, Leroy Hood, Arnold Berk, John Carbon, Robert Schimke, Arno Motulsky, Marvin H. Caruthers, and Dave Gibson.[18] In October, Amgen named George Rathmann its first president and chief executive officer.[17]
  • 1983: On June 17, Amgen went public, selling two million common shares and raising nearly $40 million.[19][20][21] That same year, after more than two years of work, an Amgen research team led by Fu-Kuen Lin had a breakthrough in finding and cloning the erythropoietin gene, a protein created in the kidney that stimulates red blood cell production. Lin's team created what would become Epogen (epoetin alfa).[22][23]
  • 1984: In June, Amgen and Kirin formed a joint venture giving Kirin the rights to Epogen in Japan.[24]
  • 1985: Amgen researcher Larry Souza and his team cloned granulocyte colony-stimulating factor (G-CSF), leading to the development of Neupogen (filgrastim).[23][25][26]
  • 1988: In October, Gordon Binder was named CEO, succeeding George Rathmann.[27]
  • 1989: Amgen received approval for the first recombinant human erythropoetin product, Epogen (epoetin alfa).[28][29]
  • 1991: In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.[30] A 2002 meta-analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38%, reduced the risk of documented infection by 49%, and reduced the risk of infection-related mortality by 40%.[31]
  • 1993: In March, Amgen opened a new manufacturing facility in Puerto Rico, which later became the company's flagship manufacturing site.[32]
  • 1994: Amgen became the fifth company to receive the U.S. Department of Commerce's National Medal of Technology and Innovation, in recognition of its work developing medicines to improve quality of life for kidney and cancer patients.[33] Also around this time, Amgen researcher Steve Elliott and his team added more sugar molecules to erythropoietin, causing it to remain in the body longer. This led to the development of Aranesp (darbepoetin alfa).[34]
  • 1998: In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha).[28] A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors "are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints."[35] A more recent study demonstrated that compared to traditional disease-modifying anti-rheumatic drugs, treatment with etanercept improved survival, reduced cardiovascular events and reduced the incidence of hematological cancers.[36]
  • 2000: In May, Kevin Sharer became Amgen's third CEO, following Gordon Binder's retirement.[37]
  • 2001: Aranesp received FDA approval in September.[38]
  • 2002: At the beginning of the year, the FDA approved Neulasta.[39] In July, Amgen acquired Immunex, the developer of Enbrel (etanercept).[40]
  • 2004: Sensipar (cinacalcet) was approved by the FDA.[41][42] Also, Amgen acquired Tularik, another biotechnology company, expanding the company's research and development pipeline.[43][44]
  • 2006: In April, Amgen acquired Abgenix, the developer of Vectibix (panitumumab), a treatment developed for certain patients with metastatic colorectal cancer.[45] Vectibix was approved by the FDA in September 2006.[46]
  • 2008: In August, Nplate (romiplostim) was approved by the FDA.[47][48]
  • 2010: On June 6, 2010, Amgen received FDA approval for Prolia, a protein drug for the treatment of post-menopausal osteoporosis.[49] In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%.[50] In November 2010 the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors.[51] The clinical trials primarily enrolled patients with breast or prostate cancer.
  • 2011: Amgen acquired a manufacturing facility near Dublin, Ireland, in March.[52] In May, Amgen acquired BioVex,[53] developer of Imlygic (talimogene laherparepvec).[54] In December, Amgen and Watson Pharmaceuticals announced a collaboration to develop and commercialize several biosimilar medicines worldwide.[55]
  • 2012: Illegal marketing practices. The Los Angeles Times reported on December 18, 2012, that Amgen pleaded guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related whistleblower complaints. Federal prosecutors accused the company of pursuing profits while putting patients at risk.[56] Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices".[57] One of the drugs mentioned in the lawsuit had sales of $492 million in the third quarter of 2012, down 17% from the same quarter the previous year due to "reimbursement problems and label changes".[58]
  • 2013: Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years. The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated $500 million[59] but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending.[60][61] Amgen acquired Micromet, a company focused on BiTE technology, in March.[62] In May, Kevin Sharer retired, and Robert Bradway, formerly Amgen's president and chief operating officer, became CEO.[63] In June, Amgen acquired Turkish company Mustafa Nevzat Pharmaceuticals, expanding Amgen's presence in Turkey and nearby areas.[64] In July, Amgen acquired KAI Pharmaceuticals, developer of Parsabiv (etelcalcetide).[65][66] Amgen acquired Iceland-based deCODE Genetics in December.[67] Amgen also opened an affiliate in China.[68][69]
  • 2013: In October, Amgen acquired Onyx Pharmaceuticals, developer of Kyprolis (carfilzomib).[70]
  • 2014: In November the company announced it was halting all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without.[71] Later in the same week, the company in conjunction with AstraZeneca reported positive results for brodalumab in a Phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis.[72]
  • 2014: In November, construction was completed on Amgen's next-generation biomanufacturing facility in Singapore.[73] Blincyto (blinatumomab) was approved by the FDA in December.[74][75]
  • 2015: In March, the company announced it would license its Phase II candidate drug AMG 714 to developer Celimmune who plan to develop the anti-IL-15 monoclonal antibody for treatment against diet nonresponsive celiac disease and refractory celiac disease.[76]
  • 2015: Repatha (evolocumab) was approved by the FDA in August.[77] In September the company announced it would acquire Dezima Pharma for more than $1.55 billion.[78] The same day the company announced a collaboration with Xencor on 6 early stage immuno-oncology and inflammation programmes. As part of the deal Amgen will pay $45 million upfront, with the deal being worth up to another $1.7 billion.[79][80] In October, the FDA approved Imlygic.[81]
  • 2016: In September, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[82] Also in September, the FDA approved Amjevita (adalimumab-atto).[83]
  • 2017: Cash returned to shareholders totalled a record $6.5 billion through dividends and share repurchases.[84] The FDA approved Parsabiv in February[85] and Mvasi (bevacizumab-awwb) in September.[86] In October, the Amgen Foundation pledged $3 million to Khan Academy to support the development of free online biology lessons.[87][88]
  • 2018: Amgen was ranked 123 on the Fortune 500 list of the largest United States corporations by revenue.[89] In May, Aimovig (erenumab-aooe) was approved by the FDA.[90] Amgen began constructing a next-generation biomanufacturing plant at its West Greenwich, Rhode Island, campus in July.[91]
  • 2019: In January, Evenity (romosozumab) received approval in Japan,[92][93] followed by FDA approval in April.[94] In June, Kanjinti (trastuzumab-anns) was approved by the FDA.[95] Amgen announced it would acquire Nuevolution AB for 1.61 billion Swedish crowns ($166.8 million) to enhance its drug discovery capabilities.[96] In August the company announced it would acquire the Otezla drug programme from Celgene for $13.4 billion, as part of Celgene and Bristol-Myers Squibbs merger deal.[97][98] In October, Amgen announced it would be acquiring a 20.5% stake in the Beijing-based BeiGene for $2.7 billion.[99] In November, Amgen awarded a $2 million grant to the CDC Foundation to launch the latter's EmPOWERED Health Program, promoting patient engagement in decision making for their cancer treatment.[100] In December, the FDA approved Avsola (infliximab-axxq).[101]
  • 2020: In January, the Amgen Foundation and Harvard University debuted LabXchange, a free online science education platform.[102][103] Amgen and the Amgen Foundation announced a commitment of up to $12.5 million to support COVID-19 relief efforts in March.[104] In April, Amgen established Amgen K.K. as the company's wholly-owned affiliate in Japan.[105][106] Amgen announced in July that the United States Court of Appeals for the Federal Circuit had upheld the validity of two Amgen patents that described and claimed Enbrel and methods for making it. The appellate court affirmed an August 2019 decision by the United States District Court for the District of New Jersey and rejected Sandoz's attempt to invalidate the patents on Enbrel.[107] Also in July, Amgen granted an additional $3 million Khan Academy to support educational equity and science learning.[108][109] Amgen joined the Dow Jones Industrial Average on August 24, 2020.[110] In September, Amgen and Eli Lilly and Company announced a global manufacturing collaboration for COVID-19 antibody therapies.[111] On December 10, Amgen announced that it joined OneTen, a coalition of large employers that aims to hire and advance one million black Americans over the next ten years.[112] Later that month, the FDA approved Riabni (rituximab-arrx), a biosimilar to Rituxan.[113]
  • 2021: In March, the company announced it would acquire Five Prime Therapeutics and its lead candidate, bemarituzumab, for $1.9 billion[114][115] and Rodeo Therapeutics for up to $720 million.[116] The FDA approved Amgen's Lumakras in May for treatment of patients with KRAS-G12C-mutated non-small cell lung cancer.[117] In June, Amgen and Kyowa Kirin announced joint plans to develop and commercialize a treatment for atopic dermatitis.[118] In July, Amgen acquired Teneobio for $900 million. In October, Amgen and Neumora Therapeutics announced a research and development collaboration focused on novel precision therapies for certain brain diseases.[119][120] Amgen began construction on a new biomanufacturing plant in New Albany, Ohio, in November.[121] In December, the FDA approved Amgen and AstraZeneca's Tezspire (tezepelumab) for severe asthma.[122] The FDA also approved Amgen's Otezla for adults with plaque psoriasis of any severity level.[123]
  • 2022: In January, Amgen announced a research collaboration with Generate Biomedicines across multiple modalities and several therapeutic areas for up to $1.9 billion.[124][125] The company also launched a multi-target collaboration with Arrakis Therapeutics to identify novel targeted RNA degrader therapeutics.[126][127] The next month, Amgen entered a multi-year collaboration with Plexium to discover novel targeted protein degradation therapies.[128][129] Also in February, Amgen issued its first green bond to fund various environmentally friendly initiatives across the company.[130][131] The company broke ground on a new manufacturing facility in Holly Springs, North Carolina, in March.[132][133] In August, the company agreed to acquire ChemoCentryx for $3.7 billion in an all-cash deal. ChemoCentryx is the maker of Tavneos—a drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody-associated vasculitis—which was approved last year.[134] In December, the company announced it would acquire Horizon Therapeutics for $27.8 billion ($116.50 in cash for each Horizon share, a 20% premium) expanding its rare disease treatments.[135]
  • 2023: Amgen completed the acquisition of Horizon Therapeutics in October 2023.[136]

Acquisition history edit

The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):
  • Amgen (Founded 1983 as Applied Molecular Genetics)
    • Synergen Inc (Acq 1994)
    • Kinetix Pharmaceuticals Inc (Acq 2000)
    • Immunex Corporation (Acq 2002)
    • Tularik Inc (Acq 2004)
    • Abgenix Inc (Acq 2006)
    • Avidia Inc (Acq 2006)
    • Alantos Pharmaceuticals (Acq 2007)
    • Ilypsa Inc (Acq 2007)
    • BioVex Group Inc (Acq 2011)
    • Micromet Inc (Acq 2012)
    • Mustafa Nevzat İlaç (Acq 2012)
    • KAI Pharmaceuticals (Acq 2012)
    • deCODE genetics (Acq 2012)
    • Onyx Pharmaceuticals (Acq 2013)
    • NextCODE genetics (Spun off 2013)
    • Dezima Pharma (Acq 2015)
    • Catherex (Acq 2015)
    • Nuevolution AB (Acq 2019)
    • Otezla (apremilast) (Acq 2019)[137]
    • Five Prime Therapeutics (Acq 2021)[138]
    • Rodeo Therapeutics Corporation (Acq 2021)[139]
    • Teneobio (Acq 2021)
    • ChemoCentryx (Acq 2022)[140]
    • Horizon Therapeutics (Acq 2023)
      • Vidara Therapeutics International (Acq 2014)
      • Hyperion Therapeutics (Acq 2015)
      • Crealta Holdings (Acq 2015)
      • Raptor Pharmaceutical (Acq 2016)
      • River Vision Development Corp. (Acq 2017)
      • Viela Bio Inc (Acq 2021)

Products edit

Amgen's approved drugs or therapeutic biologicals include:

Products developed and then sold off edit

Pipeline and clinical trials edit

As of August 2022, Amgen had 17 clinical programs underway in Phase III, eight in Phase II, and 19 in Phase I.[145]

In September 2019, FDA granted fast track designation to sotorasib for the treatment of metastatic non-small-cell lung carcinoma (NSCLC) with the KRAS G12C mutation.[146]

In August 2020, Amgen, Takeda, and AbbVie, as part of a COVID-19 research and development (R&D) alliance, announced the first patients enrolled in the I-SPY COVID clinical trial. The trial evaluated the efficacy of Otezla and two other medicines in severely ill, hospitalized COVID-19 patients who required high-flow oxygen.[147]

In October 2020, Amgen announced positive topline Phase 2 results from the CodeBreaK 100 clinical study, evaluating sotorasib in 126 patients with KRAS G12C-mutant advanced NSCLC who had failed three or fewer prior lines of anti-cancer therapies (including immunotherapy and/or chemotherapy).[148] Amgen, the Global Coalition for Adaptive Research, and Eisai Co., Ltd. also announced enrollment of the first patient in a study testing multiple interventions for the treatment of patients hospitalized with COVID-19.[149][150]

In November 2020, Amgen, Takeda, and UCB, as part of the COVID R&D alliance, announced the first patient enrolled in another trial evaluating Otezla and two other drugs as treatments for COVID-19.[151] Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv mecarbil and AMG 594.[152] Amgen and AstraZeneca announced positive topline results from a Phase 3 trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations in patients with severe asthma.[153]

In December 2020, the FDA granted breakthrough therapy designation to sotorasib for advanced or metastatic non-small cell lung cancer patients with KRAS G12C mutation.[154]

In May 2021, sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation.[155] Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe[156] and Japan.[157]

In September 2022, data from a late-stage study showed the company's cancer pill Lumakras beating out chemotherapy. This was the first approved drug in the set of treatments that target KRAS, among the most common generic mutations found in cancers but one where researchers have struggled for years to design drugs to treat. The drug was approved in 2021 with a list price of $17,900 per month.[158]

Carbon footprint edit

Amgen reported Total CO2e emissions (Direct + Indirect) for the twelve months ending 31 December 2020 at 243 Kt (-6 /-2.4% y-o-y)[159] and aims to reach net zero emissions by 2027.[160]

Amgen's annual Total CO2e Emissions - Location-Based Scope 1 + Scope 2 (in kilotonnes)[159]
Dec 2014 Dec 2015 Dec 2016 Dec 2017 Dec 2018 Dec 2019 Dec 2020
354 369 292 279 264 249 243

Public-private engagement edit

Amgen engages with the public and private sectors in a variety of settings including to promote research and development, academic funding, event sponsorship, philanthropy, and political lobbying.

Academia edit

Events and conferences edit

Health care edit

Media edit

Medical societies edit

Political lobbying edit

Professional associations edit

Research and development edit

See also edit

References edit

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December 04, 2023
amgen, this, article, rely, excessively, sources, closely, associated, with, subject, potentially, preventing, article, from, being, verifiable, neutral, please, help, improve, replacing, them, with, more, appropriate, citations, reliable, independent, third, . This article may rely excessively on sources too closely associated with the subject potentially preventing the article from being verifiable and neutral Please help improve it by replacing them with more appropriate citations to reliable independent third party sources August 2020 Learn how and when to remove this template message Amgen Inc formerly Applied Molecular Genetics Inc is an American multinational biopharmaceutical company headquartered in Thousand Oaks California 3 4 One of the world s largest independent biotechnology companies Amgen s Thousand Oaks staff in 2022 numbered approximately 5 000 5 8 5 of total city employment 6 and included hundreds of scientists making Amgen the largest employer in Ventura County 7 8 As of 2022 Amgen has approximately 24 000 staff in total 9 Amgen Inc Headquarters in Thousand Oaks CaliforniaFormerlyApplied Molecular Genetics 1980 1983 TypePublicTraded asNasdaq AMGNNasdaq 100 componentDJIA componentS amp P 100 componentS amp P 500 componentISINUS0311621009IndustryBiotechnologyFoundedApril 8 1980 43 years ago 1980 04 08 HeadquartersThousand Oaks California U S Key peopleRobert A Bradway Chairman President amp CEO ProductsAimovig Aranesp Blincyto Epogen Kineret Enbrel Kyprolis Neulasta Neupogen Nplate Parsabiv Prolia Repatha Sensipar Mimpara Vectibix XgevaRevenueUS 26 32 billion 2022 Operating incomeUS 9 57 billion 2022 Net incomeUS 6 55 billion 2022 Total assetsUS 65 12 billion 2022 Total equityUS 3 66 billion 2022 Number of employeesc 25 200 December 2022 Websiteamgen wbr comFootnotes references 1 2 In 2019 the company s largest selling products were Enbrel etanercept 10 a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases and Neulasta pegfilgrastim an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy 11 Other marketed products include Evenity romosozumab aqqg Otezla apremilast Prolia denosumab Repatha evolocumab and Lumakras sotorasib Contents 1 History 2 Timeline 2 1 Acquisition history 3 Products 3 1 Products developed and then sold off 4 Pipeline and clinical trials 5 Carbon footprint 6 Public private engagement 6 1 Academia 6 2 Events and conferences 6 3 Health care 6 4 Media 6 5 Medical societies 6 6 Political lobbying 6 7 Professional associations 6 8 Research and development 7 See also 8 References 9 External linksHistory edit nbsp AMGen corporate logo 1983 nbsp Argentine president Mauricio Macri meets with heads of Amgen in 2018 Amgen was established in Thousand Oaks in 1980 12 7 The name AMGen is a portmanteau of the company s original name Applied Molecular Genetics which became the official name of the company in 1983 three years after incorporation and coincident with its initial public offering The company s first chief executive officer from 1980 was co founder George B Rathmann followed by Gordon M Binder in 1988 13 followed by Kevin W Sharer in 2000 14 Robert A Bradway became Amgen s president and chief executive officer in May 2012 following Sharer s retirement 15 Amgen sponsored the Tour of California from 2011 to 2017 16 Timeline edit1980 Founded in Thousand Oaks California as Applied Molecular Genetics Amgen was backed by a small group of venture capitalists Its focus in early days was on recombinant DNA technology and recombinant human insulin 17 William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Norman Davidson Leroy Hood Arnold Berk John Carbon Robert Schimke Arno Motulsky Marvin H Caruthers and Dave Gibson 18 In October Amgen named George Rathmann its first president and chief executive officer 17 1983 On June 17 Amgen went public selling two million common shares and raising nearly 40 million 19 20 21 That same year after more than two years of work an Amgen research team led by Fu Kuen Lin had a breakthrough in finding and cloning the erythropoietin gene a protein created in the kidney that stimulates red blood cell production Lin s team created what would become Epogen epoetin alfa 22 23 1984 In June Amgen and Kirin formed a joint venture giving Kirin the rights to Epogen in Japan 24 1985 Amgen researcher Larry Souza and his team cloned granulocyte colony stimulating factor G CSF leading to the development of Neupogen filgrastim 23 25 26 1988 In October Gordon Binder was named CEO succeeding George Rathmann 27 1989 Amgen received approval for the first recombinant human erythropoetin product Epogen epoetin alfa 28 29 1991 In February 1991 Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy 30 A 2002 meta analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38 reduced the risk of documented infection by 49 and reduced the risk of infection related mortality by 40 31 1993 In March Amgen opened a new manufacturing facility in Puerto Rico which later became the company s flagship manufacturing site 32 1994 Amgen became the fifth company to receive the U S Department of Commerce s National Medal of Technology and Innovation in recognition of its work developing medicines to improve quality of life for kidney and cancer patients 33 Also around this time Amgen researcher Steve Elliott and his team added more sugar molecules to erythropoietin causing it to remain in the body longer This led to the development of Aranesp darbepoetin alfa 34 1998 In November 1998 Immunex a future acquisition of Amgen received approval for Enbrel etanercept the first rheumatoid arthritis drug targeting tumor necrosis factor alpha TNF alpha 28 A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs improving control of symptoms improving physical function and slowing radiographic changes in joints 35 A more recent study demonstrated that compared to traditional disease modifying anti rheumatic drugs treatment with etanercept improved survival reduced cardiovascular events and reduced the incidence of hematological cancers 36 2000 In May Kevin Sharer became Amgen s third CEO following Gordon Binder s retirement 37 2001 Aranesp received FDA approval in September 38 2002 At the beginning of the year the FDA approved Neulasta 39 In July Amgen acquired Immunex the developer of Enbrel etanercept 40 2004 Sensipar cinacalcet was approved by the FDA 41 42 Also Amgen acquired Tularik another biotechnology company expanding the company s research and development pipeline 43 44 2006 In April Amgen acquired Abgenix the developer of Vectibix panitumumab a treatment developed for certain patients with metastatic colorectal cancer 45 Vectibix was approved by the FDA in September 2006 46 2008 In August Nplate romiplostim was approved by the FDA 47 48 2010 On June 6 2010 Amgen received FDA approval for Prolia a protein drug for the treatment of post menopausal osteoporosis 49 In clinical trials Prolia reduced the rate of vertebral fractures by 61 and the risk of hip fractures by 40 50 In November 2010 the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors 51 The clinical trials primarily enrolled patients with breast or prostate cancer 2011 Amgen acquired a manufacturing facility near Dublin Ireland in March 52 In May Amgen acquired BioVex 53 developer of Imlygic talimogene laherparepvec 54 In December Amgen and Watson Pharmaceuticals announced a collaboration to develop and commercialize several biosimilar medicines worldwide 55 2012 Illegal marketing practices The Los Angeles Times reported on December 18 2012 that Amgen pleaded guilty and agreed to pay 150 million in criminal penalty and 612 million to resolve 11 related whistleblower complaints Federal prosecutors accused the company of pursuing profits while putting patients at risk 56 Larry Husten a contributor at Forbes com elaborates on AMGEN s illegal marketing practices in this case namely that the government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices 57 One of the drugs mentioned in the lawsuit had sales of 492 million in the third quarter of 2012 down 17 from the same quarter the previous year due to reimbursement problems and label changes 58 2013 Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated 500 million 59 but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending 60 61 Amgen acquired Micromet a company focused on BiTE technology in March 62 In May Kevin Sharer retired and Robert Bradway formerly Amgen s president and chief operating officer became CEO 63 In June Amgen acquired Turkish company Mustafa Nevzat Pharmaceuticals expanding Amgen s presence in Turkey and nearby areas 64 In July Amgen acquired KAI Pharmaceuticals developer of Parsabiv etelcalcetide 65 66 Amgen acquired Iceland based deCODE Genetics in December 67 Amgen also opened an affiliate in China 68 69 2013 In October Amgen acquired Onyx Pharmaceuticals developer of Kyprolis carfilzomib 70 2014 In November the company announced it was halting all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy than those without 71 Later in the same week the company in conjunction with AstraZeneca reported positive results for brodalumab in a Phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis 72 2014 In November construction was completed on Amgen s next generation biomanufacturing facility in Singapore 73 Blincyto blinatumomab was approved by the FDA in December 74 75 2015 In March the company announced it would license its Phase II candidate drug AMG 714 to developer Celimmune who plan to develop the anti IL 15 monoclonal antibody for treatment against diet nonresponsive celiac disease and refractory celiac disease 76 2015 Repatha evolocumab was approved by the FDA in August 77 In September the company announced it would acquire Dezima Pharma for more than 1 55 billion 78 The same day the company announced a collaboration with Xencor on 6 early stage immuno oncology and inflammation programmes As part of the deal Amgen will pay 45 million upfront with the deal being worth up to another 1 7 billion 79 80 In October the FDA approved Imlygic 81 2016 In September the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T cell engager compound BI 836909 now AMG 420 for use in the treatment of multiple myeloma 82 Also in September the FDA approved Amjevita adalimumab atto 83 2017 Cash returned to shareholders totalled a record 6 5 billion through dividends and share repurchases 84 The FDA approved Parsabiv in February 85 and Mvasi bevacizumab awwb in September 86 In October the Amgen Foundation pledged 3 million to Khan Academy to support the development of free online biology lessons 87 88 2018 Amgen was ranked 123 on the Fortune 500 list of the largest United States corporations by revenue 89 In May Aimovig erenumab aooe was approved by the FDA 90 Amgen began constructing a next generation biomanufacturing plant at its West Greenwich Rhode Island campus in July 91 2019 In January Evenity romosozumab received approval in Japan 92 93 followed by FDA approval in April 94 In June Kanjinti trastuzumab anns was approved by the FDA 95 Amgen announced it would acquire Nuevolution AB for 1 61 billion Swedish crowns 166 8 million to enhance its drug discovery capabilities 96 In August the company announced it would acquire the Otezla drug programme from Celgene for 13 4 billion as part of Celgene and Bristol Myers Squibbs merger deal 97 98 In October Amgen announced it would be acquiring a 20 5 stake in the Beijing based BeiGene for 2 7 billion 99 In November Amgen awarded a 2 million grant to the CDC Foundation to launch the latter s EmPOWERED Health Program promoting patient engagement in decision making for their cancer treatment 100 In December the FDA approved Avsola infliximab axxq 101 2020 In January the Amgen Foundation and Harvard University debuted LabXchange a free online science education platform 102 103 Amgen and the Amgen Foundation announced a commitment of up to 12 5 million to support COVID 19 relief efforts in March 104 In April Amgen established Amgen K K as the company s wholly owned affiliate in Japan 105 106 Amgen announced in July that the United States Court of Appeals for the Federal Circuit had upheld the validity of two Amgen patents that described and claimed Enbrel and methods for making it The appellate court affirmed an August 2019 decision by the United States District Court for the District of New Jersey and rejected Sandoz s attempt to invalidate the patents on Enbrel 107 Also in July Amgen granted an additional 3 million Khan Academy to support educational equity and science learning 108 109 Amgen joined the Dow Jones Industrial Average on August 24 2020 110 In September Amgen and Eli Lilly and Company announced a global manufacturing collaboration for COVID 19 antibody therapies 111 On December 10 Amgen announced that it joined OneTen a coalition of large employers that aims to hire and advance one million black Americans over the next ten years 112 Later that month the FDA approved Riabni rituximab arrx a biosimilar to Rituxan 113 2021 In March the company announced it would acquire Five Prime Therapeutics and its lead candidate bemarituzumab for 1 9 billion 114 115 and Rodeo Therapeutics for up to 720 million 116 The FDA approved Amgen s Lumakras in May for treatment of patients with KRAS G12C mutated non small cell lung cancer 117 In June Amgen and Kyowa Kirin announced joint plans to develop and commercialize a treatment for atopic dermatitis 118 In July Amgen acquired Teneobio for 900 million In October Amgen and Neumora Therapeutics announced a research and development collaboration focused on novel precision therapies for certain brain diseases 119 120 Amgen began construction on a new biomanufacturing plant in New Albany Ohio in November 121 In December the FDA approved Amgen and AstraZeneca s Tezspire tezepelumab for severe asthma 122 The FDA also approved Amgen s Otezla for adults with plaque psoriasis of any severity level 123 2022 In January Amgen announced a research collaboration with Generate Biomedicines across multiple modalities and several therapeutic areas for up to 1 9 billion 124 125 The company also launched a multi target collaboration with Arrakis Therapeutics to identify novel targeted RNA degrader therapeutics 126 127 The next month Amgen entered a multi year collaboration with Plexium to discover novel targeted protein degradation therapies 128 129 Also in February Amgen issued its first green bond to fund various environmentally friendly initiatives across the company 130 131 The company broke ground on a new manufacturing facility in Holly Springs North Carolina in March 132 133 In August the company agreed to acquire ChemoCentryx for 3 7 billion in an all cash deal ChemoCentryx is the maker of Tavneos a drug treatment for rare diseases called anti neutrophil cytoplasmic autoantibody associated vasculitis which was approved last year 134 In December the company announced it would acquire Horizon Therapeutics for 27 8 billion 116 50 in cash for each Horizon share a 20 premium expanding its rare disease treatments 135 2023 Amgen completed the acquisition of Horizon Therapeutics in October 2023 136 Acquisition history edit The following is an illustration of the company s major mergers and acquisitions and historical predecessors this is not a comprehensive list Amgen Founded 1983 as Applied Molecular Genetics Synergen Inc Acq 1994 Kinetix Pharmaceuticals Inc Acq 2000 Immunex Corporation Acq 2002 Tularik Inc Acq 2004 Abgenix Inc Acq 2006 Avidia Inc Acq 2006 Alantos Pharmaceuticals Acq 2007 Ilypsa Inc Acq 2007 BioVex Group Inc Acq 2011 Micromet Inc Acq 2012 Mustafa Nevzat Ilac Acq 2012 KAI Pharmaceuticals Acq 2012 deCODE genetics Acq 2012 Onyx Pharmaceuticals Acq 2013 NextCODE genetics Spun off 2013 Dezima Pharma Acq 2015 Catherex Acq 2015 Nuevolution AB Acq 2019 Otezla apremilast Acq 2019 137 Five Prime Therapeutics Acq 2021 138 Rodeo Therapeutics Corporation Acq 2021 139 Teneobio Acq 2021 ChemoCentryx Acq 2022 140 Horizon Therapeutics Acq 2023 Vidara Therapeutics International Acq 2014 Hyperion Therapeutics Acq 2015 Crealta Holdings Acq 2015 Raptor Pharmaceutical Acq 2016 River Vision Development Corp Acq 2017 Viela Bio Inc Acq 2021 Products editAmgen s approved drugs or therapeutic biologicals include Aimovig erenumab aooe for migraine headaches Amjevita adalimumab 83 Aranesp darbepoetin alfa for anemia Blincyto blinatumomab for the treatment of acute lymphoblastic leukemia 141 Corlanor ivabradine Enbrel etanercept for various forms of arthritis Epogen erythropoietin for anemia Evenity romosozumab aqqg for osteoporosis Imlygic talimogene laherparepvec for local treatment of unresectable cutaneous subcutaneous and nodal lesions in melanoma recurrent after initial surgery Kanjinti trastuzumab anns 95 Kyprolis carfilzomib Lumakras sotorasib 117 Mvasi bevacizumab awwb 86 Neulasta pegfilgrastim for neutropenia Neupogen granulocyte colony stimulating factor for neutropenia Nplate romiplostim for chronic immune thrombocytopenic purpura Otezla apremilast 142 Parsabiv etelcalcetide Prolia denosumab for postmenopausal osteoporosis Repatha evolocumab Riabni rituximab arrx 113 Sensipar Mimpara cinacalcet for primary and secondary hyperparathyroidism a mineral metabolism complication common in patients with kidney failure Tezspire tezepelumab ekko 122 Vectibix panitumumab for colon cancer Xgeva denosumab for the prevention of skeletal related events pathological fracture radiation to bone spinal cord compression or surgery to bone in adults with bone metastases from solid tumors Products developed and then sold off edit Kepivance palifermin for oral mucositis sold to Biovitrium now Swedish Orphan Biovitrum in December 2008 143 StemGen ancestim for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells 144 sold to Biovitrium now Swedish Orphan Biovitrum in December 2008 143 Kineret anakinra for rheumatoid arthritis exclusively licensed to Biovitrium now Swedish Orphan Biovitrum in December 2008 143 Pipeline and clinical trials editAs of August 2022 Amgen had 17 clinical programs underway in Phase III eight in Phase II and 19 in Phase I 145 In September 2019 FDA granted fast track designation to sotorasib for the treatment of metastatic non small cell lung carcinoma NSCLC with the KRAS G12C mutation 146 In August 2020 Amgen Takeda and AbbVie as part of a COVID 19 research and development R amp D alliance announced the first patients enrolled in the I SPY COVID clinical trial The trial evaluated the efficacy of Otezla and two other medicines in severely ill hospitalized COVID 19 patients who required high flow oxygen 147 In October 2020 Amgen announced positive topline Phase 2 results from the CodeBreaK 100 clinical study evaluating sotorasib in 126 patients with KRAS G12C mutant advanced NSCLC who had failed three or fewer prior lines of anti cancer therapies including immunotherapy and or chemotherapy 148 Amgen the Global Coalition for Adaptive Research and Eisai Co Ltd also announced enrollment of the first patient in a study testing multiple interventions for the treatment of patients hospitalized with COVID 19 149 150 In November 2020 Amgen Takeda and UCB as part of the COVID R amp D alliance announced the first patient enrolled in another trial evaluating Otezla and two other drugs as treatments for COVID 19 151 Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv mecarbil and AMG 594 152 Amgen and AstraZeneca announced positive topline results from a Phase 3 trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations in patients with severe asthma 153 In December 2020 the FDA granted breakthrough therapy designation to sotorasib for advanced or metastatic non small cell lung cancer patients with KRAS G12C mutation 154 In May 2021 sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy this was the first approved targeted therapy for tumors with any KRAS mutation 155 Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe 156 and Japan 157 In September 2022 data from a late stage study showed the company s cancer pill Lumakras beating out chemotherapy This was the first approved drug in the set of treatments that target KRAS among the most common generic mutations found in cancers but one where researchers have struggled for years to design drugs to treat The drug was approved in 2021 with a list price of 17 900 per month 158 Carbon footprint editAmgen reported Total CO2e emissions Direct Indirect for the twelve months ending 31 December 2020 at 243 Kt 6 2 4 y o y 159 and aims to reach net zero emissions by 2027 160 Amgen s annual Total CO2e Emissions Location Based Scope 1 Scope 2 in kilotonnes 159 Dec 2014 Dec 2015 Dec 2016 Dec 2017 Dec 2018 Dec 2019 Dec 2020354 369 292 279 264 249 243Public private engagement editAmgen engages with the public and private sectors in a variety of settings including to promote research and development academic funding event sponsorship philanthropy and political lobbying Academia edit Institute for Advanced Study Donor to various IAS campaigns including the IAS Park City Mathematics Institute PCMI the Regional Initiative in Science and Education RISE and the Opportunity Equation OE 161 LA Promise Fund Sponsor of the Amgen Biotech Experience Los Angeles ABE LA 162 University of Toronto Donor to U of T s Boundless campaign 163 University of Washington Donor 164 Events and conferences edit Alberta Kidney Days Virtual series sponsor 165 BC Kidney Days Sponsor 166 Mentoring in IBD Sponsor 167 Princess Margaret Cancer Centre PMCC Conference Sponsor 168 Health care edit Kingston General Hospital Donor 169 Princess Margaret Cancer Centre Donor to the Princess Margaret Cancer Foundation 170 Providence Health Care Donor 171 Scarborough Health Network Donor to the SHN Foundation 172 SickKids Donor to the SickKids Foundation 173 Sinai Health System Donor to the Sinai Health Foundation 174 St Michael s Hospital Donor 175 Sunnybrook Health Sciences Centre Donor to the Sunnybrook Foundation 176 Unity Health Toronto Donor 175 University Health Network Donor to the UHN Foundation 177 Women s College Hospital Donor 178 Media edit National Geographic Society Donor 179 Medical societies edit American Society of Hematology Corporate funder 180 Arthritis Society Canada Partner 181 Canadian Society of Hospital Pharmacists Donor to the CSHP Foundation 182 Canadian Society of Nephrology Corporate partner 183 Endocrine Society Corporate liaison board member 184 European Society of Cardiology Sponsor for the EORP registry programme 185 Federation of Medical Women in Canada Sponsor 186 Political lobbying edit Alliance for a Stronger FDA Member 187 Alliance for Aging Research Donor 188 BIOTECanada Member 189 Bipartisan Policy Center Donor 190 The Business Council Member represented by Amgen chairman and CEO Robert A Bradway 191 CDC Foundation Funding partner 192 Centre for Commercialization of Regenerative Medicine CCRM Industry partner 193 Council on Foreign Relations Affiliate 194 European Federation of Pharmaceutical Industries and Associations EFPIA Member 195 Foundation for the National Institutes of Health FNIH Donor 196 Global Health Progress Partner 197 GHP is a multinational resource hub hosted by the International Federation of Pharmaceutical Manufacturers amp Associations IFPMA Health Products Stewardship Association Member 198 Innovative Medicines Canada Member company 199 International Federation of Pharmaceutical Manufacturers amp Associations IFPMA Member 200 Life Sciences British Columbia Sponsor 201 Mayor s Fund for Los Angeles Disaster relief grant provider 202 National Health Council Member 203 Personalized Medicine Coalition Member 204 Pharmaceutical Advertising Advisory Board PAAB Client 205 PAAB maintains a collaborative relationship with Health Canada Pharmaceutical Research and Manufacturers of America PhRMA Member 206 Reagan Udall Foundation for the Food and Drug Administration Donor 207 Research America Member 208 Professional associations edit British Columbia Pharmacy Association Sponsor 209 Canadian Association of Gastroenterology Corporate sponsor 210 Canadian Association of Radiologists Corporate partner 211 Canadian Rheumatology Association Corporate sponsor 212 Canadian Urological Association Corporate sponsor 213 Colorectal Cancer Canada Sponsor 214 Ontario Medical Association Donor 215 Research and development edit Alberta Kidney Disease Network Grant provider 216 Can SOLVE CKD Network Funding partner 217 Urban Institute Donor 218 See also edit nbsp California portal nbsp Companies portalKirin Amgen v Hoechst Marion Roussel a UK patent case decided by the House of Lords Amgen Inc v Harris a United States Supreme Court case on employment law EvolocumabReferences edit About Amgen Fact Sheet amgen com Retrieved 9 March 2020 US SEC 2022 Form 10 K Amgen Inc U S Securities and Exchange Commission February 9 2023 Amgen History official site page accessed January 2 2016 Ronald Vogel Pharmaceutical Economics and Public Policy CRC Press 2007 ISBN 9781439801345 P 208 Biasotti Tony 9 April 2022 In Thousand Oaks biotech execs discuss industry s rising tide lament area s lack of housing Pacific Coast Business Times Retrieved 19 September 2022 Annual Comprehensive Financial Report City of Thousand Oaks California 30 June 2021 p 156 Retrieved 19 September 2022 a b Baker Pam 2002 Thousand Oaks Westlake Village A Contemporary Portrait Community Communications Inc p 37 ISBN 978 1581920611 Biotech giant Amgen has big plans for new plant Moorpark Acorn 16 February 2018 Talhelm Matt 7 March 2022 Amgen to offer workers an average salary of 119 510 at new facility WRAL TechWire Retrieved 20 September 2022 Blankenship Kyle 27 July 2020 The top 20 drugs by global sales in 2019 Fierce Pharma Retrieved 12 July 2022 Hagen Tony 4 February 2021 Amgen Profits Get a Ride on Biosimilar Growth The Center For Biosimilars Retrieved 12 July 2022 Bidwell Carol A 1989 The Conejo Valley Old and New Frontiers Windsor Publications p 128 ISBN 978 0897812993 Amgen Form 10 K Annual Report Filing Date Mar 24 1998 secdatabase com Retrieved Jan 8 2013 Amgen Form 10 K405 Filing Date Mar 7 2000 secdatabase com Retrieved Jan 8 2013 Amgen Form 8 K Current Report Filing Date May 24 2012 secdatabase com Retrieved Jan 8 2013 Amgen Tour of California amgentourofcalifornia com Archived from the original on 2020 02 04 Retrieved 2020 02 07 a b Walsh Robin 27 October 2010 A history of Amgen pharmaphorum com Retrieved 10 August 2022 Amgen A biotechnology success story From drug development to the mass market Archived from the original on 2014 10 24 Retrieved 2016 09 12 Small Company Initial Public Offerings June 1983 Inc com 1 September 1983 Retrieved 10 August 2022 Ward Nicholas 21 April 2019 Amgen This Beaten Down Blue Chip Is Priced To Own TheStreet Retrieved 10 August 2022 Timmerman Luke 13 May 2002 Shrewd science Biotech giant Amgen s success reflects its savvy corporate style The Seattle Times Retrieved 10 August 2022 Bate James 2 June 1989 Biotech Detective Scores Coup Amgen scientist spent years searching for the key to producing EPO Los Angeles Times Retrieved 10 August 2022 a b Kim Rachel 2019 Economics and management in the biopharmaceutical industry in the USA evolution and strategic change London Routledge pp 2002 2003 ISBN 9781351012690 Retrieved 10 August 2022 Kirin and Amgen Hormone Venture The New York Times Reuters 15 June 1984 Retrieved 10 August 2022 Murphy Barbara 20 May 1997 Souza to Run Research at Biotech King Amgen Los Angeles Times Retrieved 10 August 2022 Bendall Linda J Bradstock Kenneth F August 2014 G CSF From granulopoietic stimulant to bone marrow stem cell mobilizing agent Cytokine amp Growth Factor Reviews 25 4 355 367 doi 10 1016 j cytogfr 2014 07 011 PMID 25131807 Gordon M Binder chief executive of Amgen Los Angeles Times 17 October 1995 Retrieved 10 August 2022 a b Drugs FDA FDA Approved Drug Products Amgen and its erythropoietin drugs The Washington Post 19 July 2012 Retrieved 20 September 2022 Drugs FDA FDA Approved Drug Products Lyman GH Kuderer NM Djulbegovic B April 2002 Prophylactic granulocyte colony stimulating factor in patients receiving dose intensive cancer chemotherapy a meta analysis Am J Med 112 5 406 11 doi 10 1016 s0002 9343 02 01036 7 PMID 11904116 Spencer Dina 26 Sep 2019 5 Top Pharma Manufacturers in Puerto Rico PharmaBoardroom Retrieved 10 August 2022 Nathans Aaron 16 September 1994 Amgen Phone Entrepreneur Win Medal of Technology Los Angeles Times Retrieved 10 August 2022 A Biotech Wonder Grows Up Forbes 3 Sep 2001 Retrieved 10 August 2022 Chen YF Jobanputra P Barton P et al November 2006 A systematic review of the effectiveness of adalimumab etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost effectiveness Health Technol Assess 10 42 iii iv xi xiii 1 229 doi 10 3310 hta10420 PMID 17049139 Morgan CL Emery P Porter D et al January 2014 Treatment of rheumatoid arthritis with etanercept with reference to disease modifying anti rheumatic drugs long term safety and survival using prospective observational data Rheumatology Oxford 53 1 186 94 doi 10 1093 rheumatology ket333 PMID 24140761 Hemp Paul 1 July 2004 A Time for Growth An Interview with Amgen CEO Kevin Sharer Harvard Business Review Retrieved 10 August 2022 Pollack Andrew 19 September 2001 F D A Approves New Version of Amgen Drug The New York Times Retrieved 10 August 2022 FDA approves Amgen s new generation filgrastim product Neulasta www thepharmaletter com 2 Nov 2002 Retrieved 10 August 2022 Pollack Andrew 17 July 2002 Amgen Reports Its Takeover Of Immunex The New York Times Retrieved 10 August 2022 New FDA Approvals Relias Media 1 May 2004 Retrieved 10 August 2022 Drug Approval Package Sensipar Cinacalcet HCI NDA 021688 U S Food and Drug Administration Retrieved 10 August 2022 Gellene Denise 30 March 2004 Amgen to Buy Rival Tularik Los Angeles Times Retrieved 10 August 2022 Amgen buys remaining 79 of Tularik for 1 3B to boost R amp D pipeline The Pharma Letter 4 April 2004 Retrieved 10 August 2022 Pollack Andrew 15 December 2005 Amgen to Buy Abgenix Getting Complete Control of New Colon Cancer Drug The New York Times Retrieved 10 August 2022 Giusti Ruthann M Shastri Kaushikkumar A Cohen Martin H Keegan Patricia Pazdur Richard May 2007 FDA drug approval summary panitumumab Vectibix The Oncologist 12 5 577 583 doi 10 1634 theoncologist 12 5 577 ISSN 1083 7159 PMID 17522246 S2CID 9376408 Retrieved 10 August 2022 Heavey Susan 22 August 2008 U S FDA approves Amgen s blood platelet booster Reuters Retrieved 10 August 2022 Jamali Faranak Lemery Steven Ayalew Kassa Robottom Suzanne Robie Suh Kathy Rieves Dwaine Pazdur Richard July 2009 Romiplostim for the treatment of chronic immune idiopathic thrombocytopenic purpura Oncology Williston Park N Y 23 8 704 709 ISSN 0890 9091 PMID 19711585 Retrieved 10 August 2022 Drugs FDA FDA Approved Drug Products www accessdata fda gov PDF FDA approves Xgeva to help prevent cancer related bone injury Food and Drug Administration Amgen to buy Pfizer plant The Irish Times 11 March 2011 Retrieved 10 August 2022 Timmerman Luke 24 January 2011 Xconomy Amgen to Acquire BioVex for Up To 1B to Obtain Cancer Killing Virus Therapy Xconomy Retrieved 10 August 2022 Dangi Garimella Surabhi 28 October 2015 Cost Questions Will Follow the Approval of Amgen s Oncolytic Viral Treatment Imlygic AJMC Retrieved 10 August 2022 Pollack Andrew 20 December 2011 Amgen Plans to Team Up With Watson on Generics The New York Times Retrieved 10 August 2022 Terhune Chad 18 December 2012 Amgen pleads guilty to improper marketing of anemia drug Aranesp Los Angeles Times Retrieved 2 February 2013 Husten Larry Amgen Pleads Guilty To Misbranding Anemia Drug Aranesp Forbes Retrieved 2 February 2013 Article gt Amgen s Aranesp fails in heart trial Singapore plant planned 17 January 2013 Lipton Eric 19 January 2013 Fiscal Footnote Big Senate Gift to Drug Maker New York Times Retrieved 2 February 2013 Jon Entine New York Times Mum After Congressional Budget Office Rebukes Bungled Amgen Medicare Investigation Huffington Post 26 February 2013 CBO analysis shows keeping oral drugs out of ESRD bundle could save money Nephrology News amp Issues Archived from the original on 2013 06 05 Amgen to buy Micromet for 1 2 billion Reuters 26 January 2012 Retrieved 10 August 2022 Amgen appoints CEO Robert Bradway to chair of board PMLive 17 December 2012 Retrieved 10 August 2022 Writer GEN Staff 25 April 2012 Amgen Ponies Up 700M for Turkey s Mustafa Nevzat GEN Genetic Engineering and Biotechnology News Retrieved 10 August 2022 Amgen to Pick Up Peptide Drug Firm KAI Pharmaceuticals for 315M GEN Genetic Engineering and Biotechnology News 10 April 2012 Taylor Phil 8 February 2017 Amgen s chronic kidney disease drug Parsabiv cleared in US PMLive Retrieved 11 August 2022 Amgen Buys deCODE Genetics for 415M GEN Genetic Engineering and Biotechnology News 10 December 2012 Becker Zoey 27 June 2022 Amgen partners with Fosun to bring Otezla Parsabiv to patients in China Fierce Pharma Philippidis Alex 1 November 2019 Amgen Expands China Presence Cancer R amp D with 2 7B BeiGene Collaboration GEN Genetic Engineering and Biotechnology News Retrieved 11 August 2022 Wright Rob 27 Aug 2018 Amgen s Acquisition Of Onyx Pharmaceuticals Through The Eyes Of Tony Coles Life Science Leader Retrieved 11 August 2022 GEN News Highlights Amgen Halts Rilotumumab Trials in Advanced Gastric Cancer GEN 24 November 2014 GEN News Highlights Brodalumab s No Turkey in Phase III Amgen and AstraZeneca GEN Brennan Zachary 21 November 2014 Amgen launches 200m biomanufacturing facility in Singapore BioPharma Reporter Retrieved 11 August 2022 Przepiorka Donna Ko Chia Wen Deisseroth Albert Yancey Carolyn L Candau Chacon Reyes Chiu Haw Jyh Gehrke Brenda J Gomez Broughton Candace Kane Robert C Kirshner Susan Mehrotra Nitin Ricks Tiffany K Schmiel Deborah Song Pengfei Zhao Ping Zhou Qing Farrell Ann T Pazdur Richard 15 September 2015 FDA Approval Blinatumomab Clinical Cancer Research 21 18 4035 4039 doi 10 1158 1078 0432 CCR 15 0612 ISSN 1557 3265 PMID 26374073 S2CID 207687724 Retrieved 11 August 2022 FDA Approves Blinatumomab to Treat Rare Form of Acute Lymphoblastic Leukemia The ASCO Post 15 December 2014 Retrieved 11 August 2022 GEN News Highlights Celimmune Licenses Amgen s AMG 714 for Celiac Disease GEN Kolata Gina 27 August 2015 F D A Approves Repatha a Second Drug for Cholesterol in a Potent New Class The New York Times Retrieved 11 August 2022 For Up to 1 55B Amgen Acquires Dezima Pharma GEN 16 September 2015 Amgen bets up to 1 7B on Xencor s antibody technology FierceBiotech 16 September 2015 Amgen Xencor to Partner on Cancer Immunotherapy Inflammation Drugs GEN 16 September 2015 Tontonoz Matthew T VEC is First FDA Approved Oncolytic Virus Therapy Cancer Research Institute Retrieved 11 August 2022 Amgen Buys Rights to Myeloma BiTE Immunotherapy from Boehringer Ingelheim GEN News Highlights GEN September 2016 a b Staton Tracy 23 September 2016 Amgen s Humira biosim Amjevita passes FDA milestone on long road to market Fierce Pharma Retrieved 11 August 2022 Amgen Reports Fourth Quarter And Full Year 2017 Financial Results www amgen com Retrieved 2018 05 14 Bell Jacob 8 February 2017 Amgen secures FDA approval for hormone drug BioPharma Dive Retrieved 11 August 2022 a b FDA approves bevacizumab biosimilar Mvasi GaBI Online 22 September 2017 Retrieved 11 August 2022 Vuocolo Alex 23 June 2020 Khan Academy Founder Says 3M Grant Will Help Tackle Inequities in Virtual Education Cheddar News Retrieved 11 August 2022 D Angelo Alexa 29 October 2017 Amgen Foundation awards Khan Academy 3 million to support development of biology Ventura County Star Retrieved 11 August 2022 Fortune 500 company by revenue 2018 cial www fortune com Archived from the original on 2020 03 29 Retrieved 2019 03 18 Raedler Lisa A 15 April 2019 Aimovig Erenumab aooe First CGRP Receptor Antagonist Approved for the Prevention of Migraine in Adults American Health amp Drug Benefits 12 Retrieved 11 August 2022 Amgen s New Bio manufacturing Plant Rhode Island US Pharmaceutical Technology 10 August 2018 Retrieved 11 August 2022 Evenity gets first ever approval in Japan The Pharma Letter 9 January 2019 Retrieved 11 August 2022 Taylor Phil 9 January 2019 Amgen gets first OK for Evenity in Japan as FDA panel looms Fierce Biotech Retrieved 11 August 2022 Liu Angus 10 April 2019 Amgen bone drug Evenity finally wins its FDA green light but there s a catch Fierce Pharma Retrieved 11 August 2022 a b FDA Approves Amgen s Trastuzumab Biosimilar Kanjinti The Center For Biosimilars 13 June 2019 Retrieved 11 August 2022 Amgen to buy Copenhagen based Nuevolution for 167 million Reuters 22 May 2019 via uk reuters com Amgen to Acquire Otezla for 13 4 Billion in Cash or Approximately 11 2 Billion Net of Anticipated Future Cash Tax Benefits Amgen to buy Celgene psoriasis drug Otezla for 13 4 billion Reuters 26 August 2019 Amgen acquires stake in BeiGene to grow cancer drug business to China 31 October 2019 CDC Foundation Active Programs October 1 2020 September 30 2021 CDC Foundation 2021 12 09 Archived from the original on 2022 01 15 Retrieved 2022 08 06 FDA approves Avsola fourth Remicade biosimilar www healio com 6 Dec 2019 Retrieved 11 August 2022 Kelly Rhea 24 January 2020 Amgen and Harvard Launch Free Online Science Ed Platform Campus Technology Campus Technology Retrieved 11 August 2022 Kahn Natalie L Wang Andy Z 8 April 2020 Harvard s LabXChange Provides Platform for Remote Scientific Learning During Pandemic News The Harvard Crimson The Harvard Crimson Retrieved 11 August 2022 Amgen AT amp T Others Announce Commitments for COVID 19 Response Philanthropy News Digest 25 March 2020 Retrieved 20 September 2022 BRIEF Amgen Establishes Wholly Owned Affiliate In Japan Reuters 1 April 2020 Retrieved 11 August 2022 Liu Angus 23 January 2020 Amgen wades deeper into Asia with full control of an Astellas Japanese JV Fierce Pharma Retrieved 11 August 2022 Amgen defeats Novartis appeal over arthritis drug Enbrel s patents Reuters 1 July 2020 Retrieved 11 August 2022 Amgen Foundation awards 3 million to Khan Academy Philanthropy News Digest 24 July 2020 Retrieved 20 September 2022 Molina Brett 30 July 2020 Q amp A Khan Academy CEO Sal Khan on the new school year and virtual learning USA Today Retrieved 20 September 2022 Stevens Pippa 24 August 2020 Salesforce Amgen and Honeywell added to Dow in major shake up to the average CNBC Retrieved 11 August 2022 Blankenship Kyle 17 September 2020 Eli Lilly Amgen join forces to scale production of COVID 19 antibody cocktails Fierce Pharma Retrieved 11 August 2022 Manfredi Lucas 18 January 2021 CEOs are driving an initiative to hire train 1M Black workers over next 10 years FOXBusiness Retrieved 11 August 2022 a b FDA Approves Riabni Third Biosimilar to Rituxan Clinical Oncology News 18 December 2020 Retrieved 20 September 2022 Amgen to Acquire Five Prime Therapeutics for 1 9 Billion in Cash Amgen bets on 1 9 billion Five Prime deal to grow in Asia Pacific oncology market Reuters 4 March 2021 In Second Acquisition this Month Amgen Buys Rodeo for 721 Million a b ASCO Post Staff June 25 2021 FDA Approves Sotorasib for KRAS G12C Mutated NSCLC ASCO Post Retrieved March 4 2022 Idrus Amirah Al 1 June 2021 Amgen reunites with longtime partner Kyowa Kirin in 400M dermatitis deal Fierce Biotech Retrieved 20 September 2022 Taylor Nick Paul 7 October 2021 Meet Neumora Arch s 500M Amgen partnered play for the targeted future of neuroscience R amp D Fierce Biotech Retrieved 20 September 2022 Amgen to invest 100 million in SoftBank backed Neumora Reuters 7 October 2021 Retrieved 20 September 2022 Amgen breaks ground on new biomanufacturing facility in Ohio US NS Healthcare 8 November 2021 Retrieved 20 September 2022 a b Dunleavy Kevin 20 December 2021 Amgen AstraZeneca score FDA nod for blockbuster hopeful asthma drug Tezspire Fierce Pharma Retrieved 20 September 2022 U S FDA approves expanded use of Amgen s psoriasis drug Reuters 20 December 2021 Retrieved 20 September 2022 Armstrong Annalee 6 January 2022 Amgen chooses Generate in 1 9B biobucks deal to churn out up to 10 multispecific drugs Fierce Biotech Retrieved 23 September 2022 Philippidis Alex 6 January 2022 Amgen Generate Launch Up to 1 9B Protein Therapeutics Collaboration GEN Genetic Engineering and Biotechnology News Retrieved 23 September 2022 Armstrong Annalee 11 January 2022 JPM 2022 Amgen teams up with Arrakis to destroy disease causing RNA in 75M research deal Fierce Biotech Retrieved 23 September 2022 Pagliarulo Ned 11 January 2022 Amgen partners with Arrakis to develop drugs aimed at RNA BioPharma Dive Retrieved 23 September 2022 Shasteen Hayley 3 February 2022 Amgen and Plexium Ink 500M Targeted Protein Degradation Therapies Pact BioSpace Retrieved 23 September 2022 LaHucik Kyle 3 February 2022 Amgen enters hot protein degradation field with 500M biobucks deal with Plexium Fierce Biotech Retrieved 23 September 2022 Pequeno IV Antonio 23 February 2022 Amgen Issues Green Bond San Fernando Valley Business Journal Retrieved 23 September 2022 Mutua David Caleb 29 March 2022 Amgen Mulls More Green Bonds After Robust Interest in Debut www bloomberg com Retrieved 23 September 2022 Parker Jason 7 March 2022 Amgen expects new Holly Springs plant to be a permanent home WRAL TechWire Retrieved 11 July 2023 Sterling John 11 March 2022 Amgen Breaks Ground on NC Biomanufacturing Facility GEN Genetic Engineering and Biotechnology News Retrieved 23 September 2022 Walker Joseph 4 August 2022 Amgen to Buy ChemoCentryx for 3 7 Billion The Wall Street Journal Archived from the original on 4 August 2022 Mishra Manas Satija Bhanvi 12 December 2022 Amgen dives deeper into rare disease drugs with 27 8 BLN Horizon deal Reuters Amgen completes 27 8 billion Horizon deal Reuters 6 October 2023 Erman Michael Mishra Manas 26 August 2019 Amgen to buy Celgene psoriasis drug Otezla for 13 4 billion Reuters Retrieved 23 September 2022 Adams Ben 4 March 2021 Prime time for Five Prime as Amgen snaps up this once moribund biotech for 1 9B and its phoenix from the flames cancer asset Fierce Biotech Retrieved 23 September 2022 Idrus Amirah Al 30 March 2021 Amgen saddles up with Rodeo for a 55M trek into regenerative medicine Fierce Biotech Retrieved 23 September 2022 Philippidis Alex 5 August 2022 Amgen to Acquire ChemoCentryx for 3 7B Bolstering Autoimmune Portfolio GEN Genetic Engineering and Biotechnology News Retrieved 23 September 2022 Food and Drug Administration December 3 2014 FDA Press release Blinatumomab Jeffries Fleur 28 March 2022 Amgen shares new Otezla data at American Academy of Dermatology congress 2022 PMLive Retrieved 11 August 2022 a b c Amgen press office Biovitrum Closes Product Acquisition Deal with Amgen Archived July 3 2012 at the Wayback Machine Stemgen ancestim sobi com Archived from the original on 2013 12 30 Retrieved 2013 12 30 Amgen Pipeline Amgen Pipeline Retrieved 16 August 2022 Lisa Astor September 9 2019 FDA Grants AMG 510 Fast Track Designation for KRAS G12C NSCLC targetedonc com Retrieved November 16 2019 Liu Angus 3 August 2020 AbbVie Amgen and Takeda test anti inflammatory drugs in joint COVID 19 study Fierce Pharma Helwick Caroline 1 Feb 2021 Phase II CodeBreak 100 Validates Early Benefit for KRAS Inhibitor in NSCLC The ASCO Post Retrieved 16 August 2022 Biotech Stock Roundup GILD s Veklury Approved NVAX Provides Vaccine Update amp More Yahoo Finance 28 Oct 2020 Retrieved 16 August 2022 Ross Casey 10 November 2020 Drug companies deliver a vote of confidence in adaptive trial for Covid 19 STAT Retrieved 16 August 2022 Beasley Deena 30 November 2020 COVID R amp D Alliance launches trial of Amgen UCB Takeda drugs Reuters Retrieved 16 August 2022 Gardner Jonathan 23 Nov 2020 Amgen cuts Cytokinetics loose after heart drug disappointment BioPharma Dive Retrieved 16 August 2022 Dembeck Lauren 18 October 2021 NAVIGATOR Trial Outcomes for Tezepelumab Use in Severe Uncontrolled Asthma Pulmonology Advisor Retrieved 16 August 2022 Taylor Nick Paul 8 December 2020 Amgen plans 2020 filing for FDA approval of KRAS drug sotorasib Fierce Biotech Retrieved 16 August 2022 ASCO Post Staff June 25 2021 FDA Approves Sotorasib for KRAS G12C Mutated NSCLC ascopost com Retrieved March 4 2022 Kristi Rosa January 10 2022 Sotorasib Approved in Europe for KRAS G12C Mutated Advanced NSCLC www onclive com Retrieved March 4 2022 Audrey Sternberg January 20 2022 Sotorasib Earns Approval in Japan for KRAS G12C NSCLC cancernetwork com Retrieved March 4 2022 Walker Joseph 2022 09 12 New Cancer Drug Beats Chemotherapy in Study Wall Street Journal ISSN 0099 9660 Retrieved 2022 09 12 a b Amgen s ESG Datasheet for 2020Q4 PDF Alt URL Amgen s Sustainability Report for 2020Q4 PDF Archived from the original PDF on July 17 2021 Alt URL Simonyi Charles Dijkgraaf Robbert 2013 Report for the Academic Year 2012 2013 PDF Institute for Advanced Study Archived PDF from the original on 2022 08 02 Retrieved 2022 08 02 Amgen Biotech Experience ABE LA LA Promise Fund 2022 02 23 Archived from the original on 2022 08 06 Retrieved 2022 08 06 Donor Listing University of Toronto Archived from the original on 2021 04 23 Retrieved 2022 08 06 Honor Roll of Donors PDF University of Washington Amazon Web Services 2020 Archived PDF from the original on 2022 06 10 Retrieved 2022 08 05 BUKSA Strategic Conference Services 2021 Virtual Series Sponsor Profile Amgen Alberta Kidney Days Virtual Series Archived from the original on 2022 08 02 Retrieved 2022 08 02 Compassion in kidney care from patients to providers PDF BC Renal Agency 2013 Archived PDF from the original on 2022 01 08 Retrieved 2022 08 02 Sponsors Mentoring in IBD 2022 Archived from the original on 2022 04 19 Retrieved 2022 08 02 The 8th Princess Margaret Hospital Conference Developments in Cancer Management FDocuments India 2020 07 17 Archived from the original on 2022 06 20 Retrieved 2022 08 05 Recognizing your contribution Kingston University Hospital Foundation 2019 12 31 Archived from the original on 2022 08 03 Retrieved 2022 08 04 Fukakusa Janice Yamashita Miyo 2021 Annual Report PDF Princess Margaret Cancer Centre Archived PDF from the original on 2021 11 20 Retrieved 2022 08 05 Donor List Providence Health Care Archived from the original on 2022 02 08 Retrieved 2022 08 05 Our Donors Scarborough Health Network Foundation 2021 Archived from the original on 2022 08 05 Retrieved 2022 08 05 2020 21 SickKids Annual Report SickKids Foundation 2021 Archived from the original on 2022 06 20 Retrieved 2022 08 05 Donor List Cumulative Sinai Health Annual Report 2021 03 31 Archived from the original on 2022 08 06 Retrieved 2022 08 06 a b St Michael s Foundation 2020 21 Annual Report FlippingBook 2021 Archived from the original on 2022 08 05 Retrieved 2022 08 05 Our donors Your Impact Sunnybrook Foundation 2022 Archived from the original on 2022 08 06 Retrieved 2022 08 06 Hanson Tennys Kothari Raj 2020 21 Report to Our Donors UHN Foundation Archived from the original on 2022 05 07 Retrieved 2022 08 06 Donor Listings Women s College Hospital Foundation Archived from the original on 2022 08 05 Retrieved 2022 08 05 The Power of Philanthropy PDF National Geographic Society Archived PDF from the original on 2022 05 10 Retrieved 2022 08 04 Corporate Support American Society of Hematology 2022 Archived from the original on 2022 06 10 Retrieved 2022 08 02 Partners Arthritis Society 2022 Archived from the original on 2022 05 14 Retrieved 2022 08 02 2019 Donors to the CSHP Foundation by Giving Level Canadian Society of Hospital Pharmacists Archived from the original on 2022 04 19 Retrieved 2022 08 04 Our Partners CSN SCN 2022 Archived from the original on 2022 01 08 Retrieved 2022 08 02 Corporate Liaison Board Endocrine Society 2022 Archived from the original on 2022 06 10 Retrieved 2022 08 02 Why sponsor the EURObservational Registry Programme European Society of Cardiology 2022 Archived from the original on 2022 06 15 Retrieved 2022 08 03 AGM 2010 The Many Faces of Medical Women PDF Federation of Medical Women in Canada 2010 Archived PDF from the original on 2022 03 06 Retrieved 2022 08 03 List of Members Alliance for a Stronger FDA 2022 03 04 Archived from the original on 2022 07 08 Retrieved 2022 08 02 How We re Funded Advocacy amp Support Alliance for Aging Research 2022 Archived from the original on 2022 07 15 Retrieved 2022 08 02 Member Listings BIOTECanada 2021 12 23 Archived from the original on 2022 08 02 Retrieved 2022 08 02 Grumet Jason 2016 Dialogue Issue III The Annual Report Issue 2015 2016 PDF Bipartisan Policy Center Archived PDF from the original on 2022 07 07 Retrieved 2022 08 02 Active Members The Business Council 2022 Archived from the original on 2022 07 13 Retrieved 2022 07 02 CDC Foundation Active Programs CDC Foundation 2021 12 09 Archived from the original on 2022 01 15 Retrieved 2022 08 02 Industry Network CCRM 2019 04 10 Archived from the original on 2022 08 02 Retrieved 2022 08 02 Corporate Members Council on Foreign Relations Retrieved 2022 08 02 Membership European Federation of Pharmaceutical Industries and Associations 2022 Archived from the original on 2022 07 01 Retrieved 2022 08 02 2020 Donors FNIH 2020 Annual Report Archived from the original on 2022 03 16 Retrieved 2022 08 03 Explore Our Collaborations Global Health Progress 2022 Archived from the original on 2022 04 03 Retrieved 2022 08 04 Members Health Products Stewardship Association 2022 Archived from the original on 2022 04 27 Retrieved 2022 08 04 Member Companies Innovative Medicines Canada 2021 Archived from the original on 2022 05 31 Retrieved 2022 08 04 Companies IFPMA Archived from the original on 2022 07 01 Retrieved 2022 08 04 Our Sponsors Life Sciences British Columbia 2021 01 06 Archived from the original on 2022 04 25 Retrieved 2022 08 04 Higgins Connie 2020 04 28 Amgen Foundation commits 2M to Ventura and Los Angeles Counties COVID 19 response PDF Amgen Archived PDF from the original on 2022 07 06 Retrieved 2022 08 04 Our Members National Health Council 2022 Archived from the original on 2022 04 06 Retrieved 2022 08 05 Current Members Personalized Medicine Coalition 2021 Archived from the original on 2021 08 15 Retrieved 2022 08 05 Pharmaceutique Pharmaceutical Advertising Advisory Board Conseil Consultatif de Publicite PAAB About www paab ca Retrieved 2022 08 05 About Pharmaceutical Research and Manufacturers of America Archived from the original on 2022 08 05 Retrieved 2022 08 05 Winckler Susan C Woodcock Janet 2021 07 01 Annual Report 2020 PDF Reagan Udall Foundation Archived PDF from the original on 2022 07 12 Retrieved 2022 08 05 Member Organizations Research America 2022 Archived from the original on 2022 04 06 Retrieved 2022 08 05 Our Sponsors and Prizes BC Pharmacy Association 2022 Archived from the original on 2022 05 23 Retrieved 2022 08 02 Current Sponsors Canadian Association of Gastroenterology 2022 Archived from the original on 2022 04 21 Retrieved 2022 08 02 Corporate Partners CAR Canadian Association of Radiologists 2022 Archived from the original on 2022 07 19 Retrieved 2022 08 02 Corporate Sponsors CRA Canadian Rheumatology Association 2017 11 18 Archived from the original on 2022 03 01 Retrieved 2022 08 02 Home CUA Meeting 2022 2021 Archived from the original on 2022 05 16 Retrieved 2022 08 02 Our Partnerships Colorectal Cancer Canada 2021 Archived from the original on 2022 05 16 Retrieved 2022 08 02 Your impact Ontario Medical Association 2022 Archived from the original on 2022 08 05 Retrieved 2022 08 05 Hemmelgarn Brenda R Clement Fiona Manns Braden J Klarenbach Scott James Matthew T Ravani Pietro Pannu Neesh Ahmed Sofia B MacRae Jennifer Scott Douglas Nairne Jindal Kailash 2009 10 19 Overview of the Alberta Kidney Disease Network BMC Nephrology 10 1 30 doi 10 1186 1471 2369 10 30 ISSN 1471 2369 PMC 2770500 PMID 19840369 Funding Partners Can SOLVE CKD Network 2022 Archived from the original on 2022 08 02 Retrieved 2022 08 02 Wartell Sarah Rosen 2020 Annual Report PDF Urban Institute Archived PDF from the original on 2022 06 30 Retrieved 2022 08 05 External links edit nbsp Wikimedia Commons has media related to Amgen Official website Business data for Amgen GoogleSEC filingsYahoo Retrieved from https en wikipedia org w index php title Amgen amp oldid 1185467571, wikipedia, wiki, book, books, library,

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