It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor.[2] It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation in certain cancer patients.[3]
Referencesedit
^Amgen press office. Biovitrum Closes Product Acquisition Deal with Amgen July 3, 2012, at the Wayback Machine
^da Silva MG, Pimentel P, Carvalhais A, et al. (2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683–91. doi:10.1038/sj.bmt.1704602. PMID 15322567.
^. Archived from the original on 2016-07-29. Retrieved 2013-12-30.
ancestim, recombinant, methionyl, human, stem, cell, factor, branded, amgen, stemgen, developed, amgen, sold, biovitrium, swedish, orphan, biovitrum, december, 2008, clinical, dataahfs, drugs, cominternational, drug, namesroutes, ofadministrations, injection, . Ancestim is a recombinant methionyl human stem cell factor branded by Amgen as StemGen It was developed by Amgen and sold to Biovitrium now Swedish Orphan Biovitrum in December 2008 1 AncestimClinical dataAHFS Drugs comInternational Drug NamesRoutes ofadministrations c injection only premedication with H1 and H2 antihistamines and beta receptor agonists for bronchodilationATC codeL03AA12 WHO Pharmacokinetic dataElimination half life2 5 hExcretionrenal 90 IdentifiersCAS Number163545 26 4 NChemSpidernoneUNIIPYB4Q6JG41KEGGD02937 Y N Y what is this verify It is a 166 amino acid protein produced by E coli bacteria into which a gene has been inserted for soluble human stem cell factor 2 It has a monomeric molecular weight of approximately 18 500 daltons and normally exists as a noncovalently associated dimer The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis except for the addition of an N terminal methionine retained after expression in E coli Because Ancestim is produced in E coli it is nonglycosylated Ancestim is supplied as a sterile white preservative free lyophilised powder for reconstitution and administration as a subcutaneous SC injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation in certain cancer patients 3 References edit Amgen press office Biovitrum Closes Product Acquisition Deal with Amgen Archived July 3 2012 at the Wayback Machine da Silva MG Pimentel P Carvalhais A et al 2004 Ancestim recombinant human stem cell factor SCF in association with filgrastim does not enhance chemotherapy and or growth factor induced peripheral blood progenitor cell PBPC mobilization in patients with a prior insufficient PBPC collection Bone Marrow Transplant 34 8 683 91 doi 10 1038 sj bmt 1704602 PMID 15322567 Sobi s StemGen page Archived from the original on 2016 07 29 Retrieved 2013 12 30 nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Ancestim amp oldid 1171078718, wikipedia, wiki, book, books, library,
