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Wikipedia

James J. Collins

January 01, 1970

For other people named James Collins, see James Collins (disambiguation).

James Joseph Collins (born June 26, 1965) is an American biomedical engineer and bioengineer who serves as the Termeer Professor of Medical Engineering & Science at the Massachusetts Institute of Technology (MIT), where he is also a director at the MIT Abdul Latif Jameel Clinic for Machine Learning in Health.

James J. Collins
Born (1965-06-26) June 26, 1965 (age 58)
New York City, U.S.
EducationCollege of the Holy Cross (BA)
Balliol College, Oxford (DPhil)
Known forSynthetic biology; discovery of halicin and abaucin
Spouse
Mary McNaughton Collins
​
​
(m. 1990)​
AwardsMacArthur Fellowship (2003)
NIH Director's Pioneer Award (2007)
Lagrange Prize (2010)
HFSP Nakasone Award (2015)
Gabbay Award (2017)
Dickson Prize in Medicine (2020)
Max Delbruck Prize (2020)
Feynman Prize (2023)
Clarivate Citation Laureate (2023)
Scientific career
FieldsBiological engineering
Biomedical engineering
Systems biology
Synthetic biology
InstitutionsMassachusetts Institute of Technology
Harvard University
Boston University
Wyss Institute
Broad Institute
ThesisJoint Mechanics: Modeling of the Lower Limb (1990)
Doctoral advisorJohn O’Connor

Collins conducted research showing that artificial intelligence (AI) approaches can be used to discover novel antibiotics, such as halicin and abaucin. He serves as the Director of the Antibiotics-AI Project at MIT, which is supported by The Audacious Project, and is a member of the Harvard–MIT Program in Health Sciences and Technology. He is also a core faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard University and a member of the Broad Institute.[1]

Collins is one of the founders of the field of synthetic biology, and his work on synthetic gene circuits and programmable cells has led to the development of new classes of diagnostics and therapeutics, which have influenced research in detecting and treating infections caused by emerging pathogens such as Ebola, Zika, SARS-CoV-2, and antibiotic-resistant bacteria. He is also a researcher in systems biology, having made discoveries regarding the actions of antibiotics and the emergence of antibiotic resistance.[2]

Collins is a member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Sciences for his contributions to synthetic biology and engineered gene networks. In 2023, he was awarded a Clarivate Citation for research most likely to receive a Nobel Prize.

Early life and education edit

Collins was born on June 26, 1965, in The Bronx, then moved to Bellerose, New York.[3] His father was an aviation engineer who worked on projects for NASA and the military. At age 10, Collins moved to New Hampshire with his family after finishing elementary school,[4] growing up in Nashua.[5] He first developed an interest in medical engineering when one of his grandfathers became blind and the other suffered multiple strokes.[6]

Collins originally intended to study electrical engineering as an undergraduate and was accepted to the Massachusetts Institute of Technology (MIT) and the Rensselaer Polytechnic Institute (RPI). He decided instead to attend the College of the Holy Cross, finding the atmosphere at the college more friendly. Collins later recalled, "I fell in love with the place. I wanted to work hard and get a strong education, but I also wanted to enjoy myself. I wanted to get a broad experience, and I felt I could get that at Holy Cross".[2]

At Holy Cross, Collins was a class officer and a member of the track and cross country teams, where he was a 4:17 miler.[7] He also wrote for the school newspaper and taught as part of the Confraternity of Christian Doctrine (CCD). As an undergraduate, he had been awarded a President's Volunteer Service Award and was designated as a Fenwick Scholar in 1986, one of the college's highest honors.[8] Collins graduated from Holy Cross in 1987 as class valedictorian, receiving a Bachelor of Arts (B.A.) in physics, summa cum laude.[2] His undergraduate thesis was titled "Functional Neuromuscular Stimulation: An Analysis of the Biomechanical and Neuromuscular Foundations of Walking".[9]

After graduating, Collins was awarded a Rhodes Scholarship to study medical engineering at Balliol College, Oxford, where he earned a Doctor of Philosophy (D.Phil.) in 1990.[10] His dissertation was titled "Joint Mechanics: Modelling of the Lower Limb" and was supervised by John J. O'Connor.[11]

Career edit

Collins returned to the United States to join the faculty of Boston University. There, he established a laboratory and became the university's William F. Warren Distinguished Professor, a University Professor, a professor of biomedical engineering, a professor of medicine, and co-director of the Center for BioDynamics and Director of the Center of Synthetic Biology. In 2008, Collins was named as a Howard Hughes Medical Institute investigator, becoming the first investigator from Boston University.[5]

In 2014, Collins moved to become a professor at the Massachusetts Institute of Technology.[12] Currently, Collins is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT. Collins is also a core founding faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University and a member of the Broad Institute. Collins is also faculty lead for life sciences at the MIT Jameel Clinic since 2018.[13][14]

Collins has been involved with a number of start-up companies, and his inventions and technologies have been licensed by over 25 biotech and medical device companies. Collins is the scientific co-founder of several biotech companies and non-profit organizations.

In 2010, Collins was appointed by President Barack Obama to be a member of the Presidential Commission for the Study of Bioethical Issues.[15]

Work edit

Synthetic biology edit

Collins' work on synthetic gene circuits launched the field of synthetic biology.[16] He was the first (along with Michael Elowitz and Stanislas Leibler) to show that one can harness the biophysical properties of nucleic acids and proteins to create biological circuits, which can be used to rewire and reprogram living cells.

In a paper published in Nature,[17] Collins designed and constructed a genetic toggle switch – a synthetic, bistable gene regulatory network – in E. coli. The toggle switch forms a synthetic, addressable cellular memory unit with broad implications for biophysics, biomedicine and biotechnology. In the same issue of Nature, Elowitz and Leibler showed that one can build a synthetic genetic oscillator (called the repressilator) in E. coli.[18] Collins’ Nature paper on the genetic toggle switch[17] and Elowitz's and Leibler's Nature paper[18] on the repressilator are considered landmark pieces, ones that marks the beginnings of synthetic biology.[16]

Building on this work, Collins showed that synthetic gene networks can be used as regulatory modules and interfaced with a microbe's genetic circuitry to create programmable cells for a variety applications,[19] e.g., synthetic probiotics to serve as living diagnostics and living therapeutics to detect, treat and prevent infections such as cholera and C. difficile.[20][21] He also designed and constructed engineered riboregulators (RNA switches) for sensing and control,[22][23][24][25][26][27] microbial kill switches and genetic counters for biocontainment,[28][29][30] synthetic bacteriophage to combat resistant bacterial infections,[31][32] genetic switchboards for metabolic engineering,[33] and tunable genetic switches for gene and cell therapy.[34][35][36] Recently, Collins developed freeze-dried, cell-free synthetic gene circuits, an innovative platform that forms the basis for inexpensive, paper-based diagnostic tests for emerging pathogens (e.g., Zika, Ebola, SARS-CoV-2, antibiotic-resistant bacteria),[37][38][39][40] wearable biosensors,[41] and portable biomolecular manufacturing (e.g., to produce vaccine antigens) in the developing world.[42]

In the context of synthetic biology and regenerative medicine, Collins collaborated with Derrick Rossi and George Q. Daley on a study using synthetic mRNA technology for biomedical applications. The team showed that synthetic mRNA could be used for highly efficient stem cell reprogramming and redifferentiation. This work was published in Cell Stem Cell in 2010,[43] and Rossi used this synthetic biology technology platform to found Moderna.[44]

Collins has also used synthetic biology approaches (computational and experimental) to identify and address significant biological physics questions regarding the regulation of gene expression and cell dynamics. Collins, for example, has utilized synthetic gene networks to study the effects of positive feedback in genetic modules,[45][46] the role and origin of stochastic fluctuations in eukaryotic gene expression,[47] and the phenotypic consequences of gene expression noise and its effects on cell fate and microbial survival strategies in stressful environments.[48] Importantly, Collins has also demonstrated how synthetic gene circuits can be used to test, validate and improve qualitative and quantitative models of gene regulation,[49] and shown that biophysical theory and experiment can be coupled in bottom-up approaches to gain biological insights into the intricate processes of gene regulation.[50]

Antibiotics and antibiotic resistance edit

Collins is also one of the leading researchers in systems biology through the use of experimental-computational biophysical techniques to reverse engineer and analyze endogenous gene regulatory networks.[51] Collins and collaborators showed that reverse-engineered gene networks can be used to identify drug targets, biological mediators and disease biomarkers.[52]

Collins and collaborators discovered, using systems biology approaches, that all classes of bactericidal antibiotics induce a common oxidative damage cellular death pathway.[53] This finding indicates that targeting bacterials systems that remediate oxidative damage, including the SOS DNA damage response, is a viable means of enhancing the effectiveness of all major classes of antibiotics and limiting the emergence of antibiotic resistance. This work established a mechanistic relationship between bacterial metabolism and antibiotic efficacy, which was further developed and validated by Collins and his team in a series of follow-on studies.[54]

Collins showed that certain metabolites could be used to enable bactericidal antibiotics to eradicate persistent, tolerant infections.[55] Additionally, Collins and co-workers discovered that sublethal levels of antibiotics activate mutagenesis by stimulating the production of reactive oxygen species, leading to multidrug resistance.[56] Collins and colleagues, using their systems approaches, also discovered a population-based resistance mechanism constituting a form of kin selection whereby a small number of resistant bacterial mutants, in the face of antibiotic stress, can, at some cost to themselves, provide protection to other more vulnerable, cells, enhancing the survival capacity of the overall population in stressful environments.[57]

In 2020, Collins was part of the team—with fellow MIT Jameel Clinic faculty lead Professor Regina Barzilay—that announced the discovery through deep learning of halicin, the first new antibiotic compound for 30 years, which kills over 35 powerful bacteria, including antimicrobial-resistant tuberculosis, the superbug C. difficile, and two of the World Health Organization's top-three most deadly bacteria.[58] In 2020, Collins, Barzilay and the MIT Jameel Clinic were also awarded funding through The Audacious Project to create the Antibiotics-AI Project and expand on the discovery of halicin in using AI to respond to the antibiotic resistance crisis through the development of new classes of antibiotics.[59]

Nonlinear dynamics in biological systems edit

Collins also pioneered the development and use of nonlinear dynamical approaches to study, mimic and improve biological function,[60] expanding our ability to understand and harness the physics of living systems. Collins, for example, proposed that input noise could be used to enhance sensory function and motor control in humans.[61][62] He and collaborators showed that touch sensation and balance control in young and older adults, patients with stroke, and patients with diabetic neuropathy could be improved with the application of sub-sensory mechanical noise,[63] e.g., via vibrating insoles.[64] This work has led to the creation of a new class of medical devices to address complications resulting from diabetic neuropathy, restore brain function following stroke, and improve elderly balance.

Awards edit

Collins' scientific accomplishments have been recognized by numerous awards, including the Dickson Prize in Medicine, the Sanofi-Institut Pasteur Award, the HFSP Nakasone Award, the Max Delbruck Prize, the Gabbay Award, the , the , the , the Lagrange Prize from the CRT Foundation in Italy, the BMES Robert A. Pritzker Award, the Promega Biotechnology Research Award, and being selected for Technology Review's inaugural TR100 100 young innovators who will shape the future of technology[65] – and the Scientific American 50 – the top 50 outstanding leaders in science and technology.[66]

Collins is a Fellow of the American Physical Society, the Institute of Physics, and the American Institute for Medical and Biological Engineering. In 2003, he received a MacArthur Foundation "Genius Award",[67] becoming the first bioengineer to receive this honor.[68] Collins' award citation noted, "Throughout his research, Collins demonstrates a proclivity for identifying abstract principles that underlie complex biological phenomena and for using these concepts to solve concrete, practical problems.". He was also honored as a Medical All-Star by the Boston Red Sox, and threw out the at a Red Sox game in Fenway Park. In 2016, Collins was named an Allen Distinguished Investigator by the Paul G. Allen Frontiers Group.[69] Collins is an elected member of all three U.S. national academies – the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. He is also an elected fellow of the American Academy of Arts and Sciences, as well as a charter fellow of the National Academy of Inventors.

Collins has received teaching awards at Boston University, including the Biomedical Engineering Teacher of the Year Award, the College of Engineering Professor of the Year Award, and the Metcalf Cup and Prize for Excellence in Teaching, which is the highest teaching honor awarded by Boston University.[70]

In 2023, Collins was named a Clarivate Citation Laureate along with Michael Elowitz and Stanislas Leibler "for pioneering work on synthetic gene circuits, which launched the field of synthetic biology".[71]

Personal life edit

Collins' wife is Mary McNaughton Collins; they met while undergraduates at Holy Cross and married in 1990. She is a professor at Harvard Medical School and a physician at Massachusetts General Hospital.[2] They have two children: Katie, a Marshall Scholar at the University of Cambridge, and Danny, a Rachel Carson Scholar at Duke University.[72][73]

References edit

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  36. ^ Cho JH, Okuma A, Sofjan K, Lee S, Collins JJ, Wong WW (2021). "Engineering advanced logic and distributed computing in human CAR immune cells". Nat Commun. 12 (1): 792. Bibcode:2021NatCo..12..792C. doi:10.1038/s41467-021-21078-7. PMC 7862674. PMID 33542232.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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  55. ^ Allison KR, Brynildsen MP, Collins JJ (2011). "Metabolite-enabled eradication of bacterial persisters by aminoglycosides". Nature. 473 (7346): 216–20. Bibcode:2011Natur.473..216A. doi:10.1038/nature10069. PMC 3145328. PMID 21562562.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  56. ^ Kohanski, MA; DePristo MA; Collins JJ. (2010). "Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis". Molecular Cell. 37 (3): 311–320. doi:10.1016/j.molcel.2010.01.003. PMC 2840266. PMID 20159551.
  57. ^ Lee, HH; Molla MN; Cantor CR; Collins JJ. (2010). "Bacterial charity work leads to population-wide resistance". Nature. 467 (7311): 82–85. Bibcode:2010Natur.467...82L. doi:10.1038/nature09354. PMC 2936489. PMID 20811456.
  58. ^ Stokes, Jonathan M.; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M.; MacNair, Craig R.; French, Shawn; Carfrae, Lindsey A.; Bloom-Ackermann, Zohar; Tran, Victoria M. (February 20, 2020). "A Deep Learning Approach to Antibiotic Discovery". Cell. 180 (4): 688–702.e13. doi:10.1016/j.cell.2020.01.021. ISSN 1097-4172. PMC 8349178. PMID 32084340.
  59. ^ "Jim Collins receives funding to harness AI for drug discovery". MIT News | Massachusetts Institute of Technology. April 23, 2020. Retrieved November 13, 2020.
  60. ^ Collins JJ (1994). "Random walking during quiet standing". Phys Rev Lett. 73 (5): 764–767. Bibcode:1994PhRvL..73..764C. doi:10.1103/PhysRevLett.73.764. PMID 10057531.
  61. ^ Collins JJ, Chow CC, Imhoff TT (1995). "Stochastic resonance without tuning". Nature. 376 (6537): 236–8. Bibcode:1995Natur.376..236C. doi:10.1038/376236a0. PMID 7617033. S2CID 4314968.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  62. ^ Collins JJ, Imhoff TT, Grigg P (1996). "Noise-enhanced information transmission in rat SA1 cutaneous mechanoreceptors via aperiodic stochastic resonance". J Neurophysiol. 76 (1): 642–5. doi:10.1152/jn.1996.76.1.642. PMID 8836253.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  63. ^ Collins JJ, Imhoff TT, Grigg P (1996). "Noise-enhanced tactile sensation". Nature. 383 (6603): 770. Bibcode:1996Natur.383..770C. doi:10.1038/383770a0. PMID 8893000. S2CID 3660648.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  64. ^ Priplata, A; Niemi J; Harry J; Lipsitz LA; Collins JJ (October 4, 2003). "Vibrating insoles and balance control in elderly people". The Lancet. 362 (9390): 1123–1124. doi:10.1016/S0140-6736(03)14470-4. PMID 14550702. S2CID 33216209.
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  66. ^ "Scientific American 50: SA 50 Winners and Contributors". Scientific American. November 21, 2005. Retrieved April 15, 2007.
  67. ^ . John D. and Catherine T. MacArthur Foundation. Archived from the original on October 16, 2007. Retrieved April 15, 2007.
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  69. ^ Shaner, Karen (April 13, 2016). "James Collins appointed 2016 Allen Distinguished Investigator". MIT News. Massachusetts Institute of Technology. Retrieved December 19, 2023.
  70. ^ Brick, Tricia (Spring 2006). . Bostonia. pp. 20–25. Archived from the original on October 19, 2012. Retrieved June 12, 2009.
  71. ^ "James J. Collins named a Citation Laureate". Harvard-MIT Health Sciences and Technology. September 22, 2023. Retrieved December 19, 2023.
  72. ^ "Healthcare and Life Sciences: James Collins". Irish America. October 5, 2022. Retrieved December 19, 2023.
  73. ^ "Duke Senior Launches Himself Towards Big Regwards". Duke Today. October 19, 2023. Retrieved February 3, 2024.

Additional references edit

External links edit

  • Collins Lab @ MIT

January 01, 1970
james, collins, other, people, named, james, collins, james, collins, disambiguation, james, joseph, collins, born, june, 1965, american, biomedical, engineer, bioengineer, serves, termeer, professor, medical, engineering, science, massachusetts, institute, te. For other people named James Collins see James Collins disambiguation James Joseph Collins born June 26 1965 is an American biomedical engineer and bioengineer who serves as the Termeer Professor of Medical Engineering amp Science at the Massachusetts Institute of Technology MIT where he is also a director at the MIT Abdul Latif Jameel Clinic for Machine Learning in Health James J CollinsBorn 1965 06 26 June 26 1965 age 58 New York City U S EducationCollege of the Holy Cross BA Balliol College Oxford DPhil Known forSynthetic biology discovery of halicin and abaucinSpouseMary McNaughton Collins m 1990 wbr AwardsMacArthur Fellowship 2003 NIH Director s Pioneer Award 2007 Lagrange Prize 2010 HFSP Nakasone Award 2015 Gabbay Award 2017 Dickson Prize in Medicine 2020 Max Delbruck Prize 2020 Feynman Prize 2023 Clarivate Citation Laureate 2023 Scientific careerFieldsBiological engineeringBiomedical engineeringSystems biologySynthetic biologyInstitutionsMassachusetts Institute of TechnologyHarvard UniversityBoston UniversityWyss InstituteBroad InstituteThesisJoint Mechanics Modeling of the Lower Limb 1990 Doctoral advisorJohn O Connor Collins conducted research showing that artificial intelligence AI approaches can be used to discover novel antibiotics such as halicin and abaucin He serves as the Director of the Antibiotics AI Project at MIT which is supported by The Audacious Project and is a member of the Harvard MIT Program in Health Sciences and Technology He is also a core faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard University and a member of the Broad Institute 1 Collins is one of the founders of the field of synthetic biology and his work on synthetic gene circuits and programmable cells has led to the development of new classes of diagnostics and therapeutics which have influenced research in detecting and treating infections caused by emerging pathogens such as Ebola Zika SARS CoV 2 and antibiotic resistant bacteria He is also a researcher in systems biology having made discoveries regarding the actions of antibiotics and the emergence of antibiotic resistance 2 Collins is a member of the National Academy of Engineering the National Academy of Medicine and the National Academy of Sciences for his contributions to synthetic biology and engineered gene networks In 2023 he was awarded a Clarivate Citation for research most likely to receive a Nobel Prize Contents 1 Early life and education 2 Career 3 Work 3 1 Synthetic biology 3 2 Antibiotics and antibiotic resistance 3 3 Nonlinear dynamics in biological systems 4 Awards 5 Personal life 6 References 6 1 Additional references 7 External linksEarly life and education editCollins was born on June 26 1965 in The Bronx then moved to Bellerose New York 3 His father was an aviation engineer who worked on projects for NASA and the military At age 10 Collins moved to New Hampshire with his family after finishing elementary school 4 growing up in Nashua 5 He first developed an interest in medical engineering when one of his grandfathers became blind and the other suffered multiple strokes 6 Collins originally intended to study electrical engineering as an undergraduate and was accepted to the Massachusetts Institute of Technology MIT and the Rensselaer Polytechnic Institute RPI He decided instead to attend the College of the Holy Cross finding the atmosphere at the college more friendly Collins later recalled I fell in love with the place I wanted to work hard and get a strong education but I also wanted to enjoy myself I wanted to get a broad experience and I felt I could get that at Holy Cross 2 At Holy Cross Collins was a class officer and a member of the track and cross country teams where he was a 4 17 miler 7 He also wrote for the school newspaper and taught as part of the Confraternity of Christian Doctrine CCD As an undergraduate he had been awarded a President s Volunteer Service Award and was designated as a Fenwick Scholar in 1986 one of the college s highest honors 8 Collins graduated from Holy Cross in 1987 as class valedictorian receiving a Bachelor of Arts B A in physics summa cum laude 2 His undergraduate thesis was titled Functional Neuromuscular Stimulation An Analysis of the Biomechanical and Neuromuscular Foundations of Walking 9 After graduating Collins was awarded a Rhodes Scholarship to study medical engineering at Balliol College Oxford where he earned a Doctor of Philosophy D Phil in 1990 10 His dissertation was titled Joint Mechanics Modelling of the Lower Limb and was supervised by John J O Connor 11 Career editCollins returned to the United States to join the faculty of Boston University There he established a laboratory and became the university s William F Warren Distinguished Professor a University Professor a professor of biomedical engineering a professor of medicine and co director of the Center for BioDynamics and Director of the Center of Synthetic Biology In 2008 Collins was named as a Howard Hughes Medical Institute investigator becoming the first investigator from Boston University 5 In 2014 Collins moved to become a professor at the Massachusetts Institute of Technology 12 Currently Collins is the Termeer Professor of Medical Engineering amp Science and Professor of Biological Engineering at MIT Collins is also a core founding faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University and a member of the Broad Institute Collins is also faculty lead for life sciences at the MIT Jameel Clinic since 2018 13 14 Collins has been involved with a number of start up companies and his inventions and technologies have been licensed by over 25 biotech and medical device companies Collins is the scientific co founder of several biotech companies and non profit organizations In 2010 Collins was appointed by President Barack Obama to be a member of the Presidential Commission for the Study of Bioethical Issues 15 Work editThis section may contain an excessive number of citations Please help remove low quality or irrelevant citations July 2023 Learn how and when to remove this message Synthetic biology edit Collins work on synthetic gene circuits launched the field of synthetic biology 16 He was the first along with Michael Elowitz and Stanislas Leibler to show that one can harness the biophysical properties of nucleic acids and proteins to create biological circuits which can be used to rewire and reprogram living cells In a paper published in Nature 17 Collins designed and constructed a genetic toggle switch a synthetic bistable gene regulatory network in E coli The toggle switch forms a synthetic addressable cellular memory unit with broad implications for biophysics biomedicine and biotechnology In the same issue of Nature Elowitz and Leibler showed that one can build a synthetic genetic oscillator called the repressilator in E coli 18 Collins Nature paper on the genetic toggle switch 17 and Elowitz s and Leibler s Nature paper 18 on the repressilator are considered landmark pieces ones that marks the beginnings of synthetic biology 16 Building on this work Collins showed that synthetic gene networks can be used as regulatory modules and interfaced with a microbe s genetic circuitry to create programmable cells for a variety applications 19 e g synthetic probiotics to serve as living diagnostics and living therapeutics to detect treat and prevent infections such as cholera and C difficile 20 21 He also designed and constructed engineered riboregulators RNA switches for sensing and control 22 23 24 25 26 27 microbial kill switches and genetic counters for biocontainment 28 29 30 synthetic bacteriophage to combat resistant bacterial infections 31 32 genetic switchboards for metabolic engineering 33 and tunable genetic switches for gene and cell therapy 34 35 36 Recently Collins developed freeze dried cell free synthetic gene circuits an innovative platform that forms the basis for inexpensive paper based diagnostic tests for emerging pathogens e g Zika Ebola SARS CoV 2 antibiotic resistant bacteria 37 38 39 40 wearable biosensors 41 and portable biomolecular manufacturing e g to produce vaccine antigens in the developing world 42 In the context of synthetic biology and regenerative medicine Collins collaborated with Derrick Rossi and George Q Daley on a study using synthetic mRNA technology for biomedical applications The team showed that synthetic mRNA could be used for highly efficient stem cell reprogramming and redifferentiation This work was published in Cell Stem Cell in 2010 43 and Rossi used this synthetic biology technology platform to found Moderna 44 Collins has also used synthetic biology approaches computational and experimental to identify and address significant biological physics questions regarding the regulation of gene expression and cell dynamics Collins for example has utilized synthetic gene networks to study the effects of positive feedback in genetic modules 45 46 the role and origin of stochastic fluctuations in eukaryotic gene expression 47 and the phenotypic consequences of gene expression noise and its effects on cell fate and microbial survival strategies in stressful environments 48 Importantly Collins has also demonstrated how synthetic gene circuits can be used to test validate and improve qualitative and quantitative models of gene regulation 49 and shown that biophysical theory and experiment can be coupled in bottom up approaches to gain biological insights into the intricate processes of gene regulation 50 Antibiotics and antibiotic resistance edit Collins is also one of the leading researchers in systems biology through the use of experimental computational biophysical techniques to reverse engineer and analyze endogenous gene regulatory networks 51 Collins and collaborators showed that reverse engineered gene networks can be used to identify drug targets biological mediators and disease biomarkers 52 Collins and collaborators discovered using systems biology approaches that all classes of bactericidal antibiotics induce a common oxidative damage cellular death pathway 53 This finding indicates that targeting bacterials systems that remediate oxidative damage including the SOS DNA damage response is a viable means of enhancing the effectiveness of all major classes of antibiotics and limiting the emergence of antibiotic resistance This work established a mechanistic relationship between bacterial metabolism and antibiotic efficacy which was further developed and validated by Collins and his team in a series of follow on studies 54 Collins showed that certain metabolites could be used to enable bactericidal antibiotics to eradicate persistent tolerant infections 55 Additionally Collins and co workers discovered that sublethal levels of antibiotics activate mutagenesis by stimulating the production of reactive oxygen species leading to multidrug resistance 56 Collins and colleagues using their systems approaches also discovered a population based resistance mechanism constituting a form of kin selection whereby a small number of resistant bacterial mutants in the face of antibiotic stress can at some cost to themselves provide protection to other more vulnerable cells enhancing the survival capacity of the overall population in stressful environments 57 In 2020 Collins was part of the team with fellow MIT Jameel Clinic faculty lead Professor Regina Barzilay that announced the discovery through deep learning of halicin the first new antibiotic compound for 30 years which kills over 35 powerful bacteria including antimicrobial resistant tuberculosis the superbug C difficile and two of the World Health Organization s top three most deadly bacteria 58 In 2020 Collins Barzilay and the MIT Jameel Clinic were also awarded funding through The Audacious Project to create the Antibiotics AI Project and expand on the discovery of halicin in using AI to respond to the antibiotic resistance crisis through the development of new classes of antibiotics 59 Nonlinear dynamics in biological systems edit Collins also pioneered the development and use of nonlinear dynamical approaches to study mimic and improve biological function 60 expanding our ability to understand and harness the physics of living systems Collins for example proposed that input noise could be used to enhance sensory function and motor control in humans 61 62 He and collaborators showed that touch sensation and balance control in young and older adults patients with stroke and patients with diabetic neuropathy could be improved with the application of sub sensory mechanical noise 63 e g via vibrating insoles 64 This work has led to the creation of a new class of medical devices to address complications resulting from diabetic neuropathy restore brain function following stroke and improve elderly balance Awards editCollins scientific accomplishments have been recognized by numerous awards including the Dickson Prize in Medicine the Sanofi Institut Pasteur Award the HFSP Nakasone Award the Max Delbruck Prize the Gabbay Award the NIH Director s Pioneer Award the Ellison Medical Foundation Senior Scholar Award in Aging the inaugural Anthony J Drexel Exceptional Achievement Award the Lagrange Prize from the CRT Foundation in Italy the BMES Robert A Pritzker Award the Promega Biotechnology Research Award and being selected for Technology Review s inaugural TR100 100 young innovators who will shape the future of technology 65 and the Scientific American 50 the top 50 outstanding leaders in science and technology 66 Collins is a Fellow of the American Physical Society the Institute of Physics and the American Institute for Medical and Biological Engineering In 2003 he received a MacArthur Foundation Genius Award 67 becoming the first bioengineer to receive this honor 68 Collins award citation noted Throughout his research Collins demonstrates a proclivity for identifying abstract principles that underlie complex biological phenomena and for using these concepts to solve concrete practical problems He was also honored as a Medical All Star by the Boston Red Sox and threw out the first pitch at a Red Sox game in Fenway Park In 2016 Collins was named an Allen Distinguished Investigator by the Paul G Allen Frontiers Group 69 Collins is an elected member of all three U S national academies the National Academy of Sciences the National Academy of Engineering and the National Academy of Medicine He is also an elected fellow of the American Academy of Arts and Sciences as well as a charter fellow of the National Academy of Inventors Collins has received teaching awards at Boston University including the Biomedical Engineering Teacher of the Year Award the College of Engineering Professor of the Year Award and the Metcalf Cup and Prize for Excellence in Teaching which is the highest teaching honor awarded by Boston University 70 In 2023 Collins was named a Clarivate Citation Laureate along with Michael Elowitz and Stanislas Leibler for pioneering work on synthetic gene circuits which launched the field of synthetic biology 71 Personal life editCollins wife is Mary McNaughton Collins they met while undergraduates at Holy Cross and married in 1990 She is a professor at Harvard Medical School and a physician at Massachusetts General Hospital 2 They have two children Katie a Marshall Scholar at the University of Cambridge and Danny a Rachel Carson Scholar at Duke University 72 73 References edit Saunders Fenella February 6 2023 Synthesizing Engineering and Biology American Scientist Sigma Xi Retrieved December 19 2023 a b c d Reardon Michael Winter 2007 The Profile James J Collins Jr 87 Holy Cross Magazine Vol 41 no 1 College of the Holy Cross p 80 Archived from the original on August 22 2016 Retrieved April 15 2007 Khan Firdos Alam May 8 2014 Biotechnology in Medical Sciences CRC Press ISBN 978 1 4822 2367 5 James Collins Ph D AIMBE College of Fellows Class of 2000 American Institute for Medical and Biological Engineering Retrieved December 19 2023 via Xconomy a b Baker Billy November 24 2008 Dream gig grants him freedom to explore The Boston Globe p 16 Retrieved December 20 2023 Trafton Anne November 14 2015 Reprogramming biology Biological engineer James Collins designs genetic circuits with novel functions MIT News Massachusetts Institute of Technology Retrieved December 19 2023 Zaman Muhammed April 20 2020 Biography of Resistance Harper ISBN 978 0062862976 Brady 2012 p 184 Past Fenwick Scholars Projects and Advisors College of the Holy Cross Retrieved December 19 2023 Dickson Prize in Medicine awarded to Balliol alumnus Balliol College Oxford University of Oxford October 28 2020 Retrieved September 4 2023 Dissertations Thesis Joint mechanics modelling of the lower limb Oxford Libraries Information System University of Oxford Retrieved December 19 2023 Collins honored by Sigma Xi Marnett steps down as dean www asbmb org Retrieved December 20 2023 Regina Barzilay James Collins and Phil Sharp join leadership of new effort on machine learning in health MIT News Massachusetts Institute of Technology October 3 2018 Retrieved November 13 2020 People J Clinic Archived from the original on November 30 2021 Retrieved November 13 2020 Jim J Collins Ph D Catalio Capital Management www cataliocapital com Retrieved December 19 2023 a b Editorial Ten years of synergy Nature 463 269 270 21 January 2010 doi 10 1038 463269b a b Gardner TS Cantor CR Collins JJ January 20 2000 Construction of a genetic toggle switch in Escherichia coli Nature 403 6767 339 342 Bibcode 2000Natur 403 339G doi 10 1038 35002131 PMID 10659857 S2CID 345059 a b Elowitz MB Leibler S 2000 A synthetic oscillatory network of transcriptional regulators Nature 403 6767 335 8 Bibcode 2000Natur 403 335E doi 10 1038 35002125 PMID 10659856 S2CID 41632754 Kobayashi H Kaern M Araki M Chung K Gardner TS Cantor CR et al 2004 Programmable cells interfacing natural and engineered gene networks Proc Natl Acad Sci U S A 101 22 8414 9 Bibcode 2004PNAS 101 8414K doi 10 1073 pnas 0402940101 PMC 420408 PMID 15159530 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Mao N Cubillos Ruiz A Cameron DE Collins JJ 2018 Probiotic strains detect and suppress cholera in mice Sci Transl Med 10 445 doi 10 1126 scitranslmed aao2586 PMC 7821980 PMID 29899022 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Cubillos Ruiz A Alcantar MA Donghia NM Cardenas P Avila Pacheco J Collins JJ 2022 An engineered live biotherapeutic for the prevention of antibiotic induced dysbiosis Nat Biomed Eng 6 7 910 921 doi 10 1038 s41551 022 00871 9 PMID 35411114 S2CID 248100868 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Isaacs FJ Dwyer DJ Ding C Pervouchine DD Cantor CR Collins JJ 2004 Engineered riboregulators enable post transcriptional control of gene expression Nat Biotechnol 22 7 823 4 2004 doi 10 1038 nbt986 PMID 15208640 S2CID 7289450 Green AA Silver PA Collins JJ Yin P 2014 Toehold switches de novo designed regulators of gene expression Cell 159 4 925 39 doi 10 1016 j cell 2014 10 002 PMC 4265554 PMID 25417166 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Green AA Kim J Ma D Silver PA Collins JJ Yin P 2017 Complex cellular logic computation using ribocomputing devices Nature 548 7665 117 121 Bibcode 2017Natur 548 117G doi 10 1038 nature23271 PMC 6078203 PMID 28746304 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Angenent Mari NM Garruss AS Soenksen LR Church G Collins JJ 2020 A deep learning approach to programmable RNA switches Nat Commun 11 1 5057 Bibcode 2020NatCo 11 5057A doi 10 1038 s41467 020 18677 1 PMC 7541447 PMID 33028812 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Zhao EM Mao AS de Puig H Zhang K Tippens ND Tan X et al 2022 RNA responsive elements for eukaryotic translational control Nat Biotechnol 40 4 539 545 doi 10 1038 s41587 021 01068 2 PMID 34711989 S2CID 240153815 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Gayet RV Ilia K Razavi S Tippens ND Lalwani MA Zhang K et al 2023 Autocatalytic base editing for RNA responsive translational control Nat Commun 14 1 1339 Bibcode 2023NatCo 14 1339G doi 10 1038 s41467 023 36851 z PMC 10008589 PMID 36906659 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Friedland AE Lu TK Wang X Shi D Church G Collins JJ 2009 Synthetic gene networks that count Science 324 5931 1199 202 Bibcode 2009Sci 324 1199F doi 10 1126 science 1172005 PMC 2690711 PMID 19478183 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Callura JM Dwyer DJ Isaacs FJ Cantor CR Collins JJ 2010 Tracking tuning and terminating microbial physiology using synthetic riboregulators Proc Natl Acad Sci U S A 107 36 15898 903 Bibcode 2010PNAS 10715898C doi 10 1073 pnas 1009747107 PMC 2936621 PMID 20713708 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Chan CT Lee JW Cameron DE Bashor CJ Collins JJ 2016 Deadman and Passcode microbial kill switches for bacterial containment Nat Chem Biol 12 2 82 6 doi 10 1038 nchembio 1979 PMC 4718764 PMID 26641934 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Lu TK Collins JJ 2007 Dispersing biofilms with engineered enzymatic bacteriophage Proc Natl Acad Sci U S A 104 27 11197 202 Bibcode 2007PNAS 10411197L doi 10 1073 pnas 0704624104 PMC 1899193 PMID 17592147 Lu TK Collins JJ 2009 Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy Proc Natl Acad Sci U S A 106 12 4629 34 Bibcode 2009PNAS 106 4629L doi 10 1073 pnas 0800442106 PMC 2649960 PMID 19255432 Callura JM Cantor CR Collins JJ 2012 Genetic switchboard for synthetic biology applications Proc Natl Acad Sci U S A 109 15 5850 5 Bibcode 2012PNAS 109 5850C doi 10 1073 pnas 1203808109 PMC 3326468 PMID 22454498 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Deans TL Cantor CR Collins JJ 2007 A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells Cell 130 2 363 72 doi 10 1016 j cell 2007 05 045 PMID 17662949 S2CID 7960766 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Cho JH Collins JJ Wong WW 2018 Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses Cell 173 6 1426 1438 e11 doi 10 1016 j cell 2018 03 038 PMC 5984158 PMID 29706540 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Cho JH Okuma A Sofjan K Lee S Collins JJ Wong WW 2021 Engineering advanced logic and distributed computing in human CAR immune cells Nat Commun 12 1 792 Bibcode 2021NatCo 12 792C doi 10 1038 s41467 021 21078 7 PMC 7862674 PMID 33542232 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Pardee K Green AA Ferrante T Cameron DE DaleyKeyser A Yin P et al 2014 Paper based synthetic gene networks Cell 159 4 940 54 doi 10 1016 j cell 2014 10 004 PMC 4243060 PMID 25417167 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Pardee K Green AA Takahashi MK Braff D Lambert G Lee JW et al 2016 Rapid Low Cost Detection of Zika Virus Using Programmable Biomolecular Components Cell 165 5 1255 1266 doi 10 1016 j cell 2016 04 059 hdl 1721 1 109241 PMID 27160350 S2CID 3278532 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link de Puig H Lee RA Najjar D Tan X Soeknsen LR Angenent Mari NM et al 2021 Minimally instrumented SHERLOCK miSHERLOCK for CRISPR based point of care diagnosis of SARS CoV 2 and emerging variants Sci Adv 7 32 Bibcode 2021SciA 7 2944D doi 10 1126 sciadv abh2944 PMC 8346217 PMID 34362739 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Karlikow M da Silva SJR Guo Y Cicek S Krokovsky L Homme P et al 2022 Field validation of the performance of paper based tests for the detection of the Zika and chikungunya viruses in serum samples Nat Biomed Eng 6 3 246 256 doi 10 1038 s41551 022 00850 0 PMC 8940623 PMID 35256758 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Nguyen PQ Soenksen LR Donghia NM Angenent Mari NM de Puig H Huang A et al 2021 Wearable materials with embedded synthetic biology sensors for biomolecule detection Nat Biotechnol 39 11 1366 1374 doi 10 1038 s41587 021 00950 3 hdl 1721 1 131278 PMID 34183860 S2CID 235673261 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Pardee K Slomovic S Nguyen PQ Lee JW Donghia N Burrill D et al 2016 Portable On Demand Biomolecular Manufacturing Cell 167 1 248 259 e12 doi 10 1016 j cell 2016 09 013 hdl 1721 1 111574 PMID 27662092 S2CID 8481521 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Warren L Manos PD Ahfeldt T Loh YH Li H Lau F et al 2010 Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 7 5 618 30 doi 10 1016 j stem 2010 08 012 PMC 3656821 PMID 20888316 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Kutz Erin October 4 2010 ModeRNA Stealth Startup Backed By Flagship Unveils New Way to Make Stem Cells Xconomy Inc Hasty J Pradines J Dolnik M Collins JJ 2000 Noise based switches and amplifiers for gene expression Proc Natl Acad Sci U S A 97 5 2075 80 arXiv physics 0003105 Bibcode 2000PNAS 97 2075H doi 10 1073 pnas 040411297 PMC 15756 PMID 10681449 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Isaacs FJ Hasty J Cantor CR Collins JJ 2003 Prediction and measurement of an autoregulatory genetic module Proc Natl Acad Sci U S A 100 13 7714 9 Bibcode 2003PNAS 100 7714I doi 10 1073 pnas 1332628100 PMC 164653 PMID 12808135 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Blake WJ KAErn M Cantor CR Collins JJ 2003 Noise in eukaryotic gene expression Nature 422 6932 633 7 Bibcode 2003Natur 422 633B doi 10 1038 nature01546 PMID 12687005 S2CID 4347106 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Blake WJ Balazsi G Kohanski MA Isaacs FJ Murphy KF Kuang Y et al 2006 Phenotypic consequences of promoter mediated transcriptional noise Mol Cell 24 6 853 65 doi 10 1016 j molcel 2006 11 003 PMID 17189188 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Ellis T Wang X Collins JJ 2009 Diversity based model guided construction of synthetic gene networks with predicted functions Nat Biotechnol 27 5 465 71 doi 10 1038 nbt 1536 PMC 2680460 PMID 19377462 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Guido NJ Wang X Adalsteinsson D McMillen D Hasty J Cantor CR et al 2006 A bottom up approach to gene regulation Nature 439 7078 856 60 Bibcode 2006Natur 439 856G doi 10 1038 nature04473 PMID 16482159 S2CID 4418558 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Yeung MK Tegner J Collins JJ 2002 Reverse engineering gene networks using singular value decomposition and robust regression Proc Natl Acad Sci U S A 99 9 6163 8 Bibcode 2002PNAS 99 6163Y doi 10 1073 pnas 092576199 PMC 122920 PMID 11983907 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Gardner TS di Bernardo D Lorenz D Collins JJ July 4 2003 Inferring genetic networks and identifying compound of action via expression profiling Science 301 5629 102 105 doi 10 1126 science 1081900 PMID 12843395 S2CID 8356492 Kohanski MA Dwyer DJ Hayete B Lawrence CA Collins JJ 2007 A common mechanism of cellular death induced by bactericidal antibiotics Cell 130 5 797 810 doi 10 1016 j cell 2007 06 049 PMID 17803904 S2CID 1103795 Kohanski MA Dwyer DJ Wierzbowski J Cottarel G Collins JJ 2008 Mistranslation of membrane proteins and two component system activation trigger antibiotic mediated cell death Cell 135 4 679 90 doi 10 1016 j cell 2008 09 038 PMC 2684502 PMID 19013277 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Allison KR Brynildsen MP Collins JJ 2011 Metabolite enabled eradication of bacterial persisters by aminoglycosides Nature 473 7346 216 20 Bibcode 2011Natur 473 216A doi 10 1038 nature10069 PMC 3145328 PMID 21562562 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Kohanski MA DePristo MA Collins JJ 2010 Sublethal antibiotic treatment leads to multidrug resistance via radical induced mutagenesis Molecular Cell 37 3 311 320 doi 10 1016 j molcel 2010 01 003 PMC 2840266 PMID 20159551 Lee HH Molla MN Cantor CR Collins JJ 2010 Bacterial charity work leads to population wide resistance Nature 467 7311 82 85 Bibcode 2010Natur 467 82L doi 10 1038 nature09354 PMC 2936489 PMID 20811456 Stokes Jonathan M Yang Kevin Swanson Kyle Jin Wengong Cubillos Ruiz Andres Donghia Nina M MacNair Craig R French Shawn Carfrae Lindsey A Bloom Ackermann Zohar Tran Victoria M February 20 2020 A Deep Learning Approach to Antibiotic Discovery Cell 180 4 688 702 e13 doi 10 1016 j cell 2020 01 021 ISSN 1097 4172 PMC 8349178 PMID 32084340 Jim Collins receives funding to harness AI for drug discovery MIT News Massachusetts Institute of Technology April 23 2020 Retrieved November 13 2020 Collins JJ 1994 Random walking during quiet standing Phys Rev Lett 73 5 764 767 Bibcode 1994PhRvL 73 764C doi 10 1103 PhysRevLett 73 764 PMID 10057531 Collins JJ Chow CC Imhoff TT 1995 Stochastic resonance without tuning Nature 376 6537 236 8 Bibcode 1995Natur 376 236C doi 10 1038 376236a0 PMID 7617033 S2CID 4314968 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Collins JJ Imhoff TT Grigg P 1996 Noise enhanced information transmission in rat SA1 cutaneous mechanoreceptors via aperiodic stochastic resonance J Neurophysiol 76 1 642 5 doi 10 1152 jn 1996 76 1 642 PMID 8836253 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Collins JJ Imhoff TT Grigg P 1996 Noise enhanced tactile sensation Nature 383 6603 770 Bibcode 1996Natur 383 770C doi 10 1038 383770a0 PMID 8893000 S2CID 3660648 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Priplata A Niemi J Harry J Lipsitz LA Collins JJ October 4 2003 Vibrating insoles and balance control in elderly people The Lancet 362 9390 1123 1124 doi 10 1016 S0140 6736 03 14470 4 PMID 14550702 S2CID 33216209 1999 Young Innovator James Collins Technology Review November December 1999 Retrieved April 15 2007 Scientific American 50 SA 50 Winners and Contributors Scientific American November 21 2005 Retrieved April 15 2007 MacArthur Fellows October 2003 John D and Catherine T MacArthur Foundation Archived from the original on October 16 2007 Retrieved April 15 2007 Tucker Ian May 21 2011 James Collins A spoonful of sugar helps the medicine go down The Guardian ISSN 0261 3077 Retrieved April 22 2024 Shaner Karen April 13 2016 James Collins appointed 2016 Allen Distinguished Investigator MIT News Massachusetts Institute of Technology Retrieved December 19 2023 Brick Tricia Spring 2006 Genius at Work Bostonia pp 20 25 Archived from the original on October 19 2012 Retrieved June 12 2009 James J Collins named a Citation Laureate Harvard MIT Health Sciences and Technology September 22 2023 Retrieved December 19 2023 Healthcare and Life Sciences James Collins Irish America October 5 2022 Retrieved December 19 2023 Duke Senior Launches Himself Towards Big Regwards Duke Today October 19 2023 Retrieved February 3 2024 Additional references edit Brady Diane 2012 Fraternity Spiegel amp Grau published January 3 2012 ISBN 978 0385524742 External links editCollins Lab MIT Jim Collins faculty webpage the Wyss Institute Harvard University Retrieved from https en wikipedia org w index php title James J Collins amp oldid 1220759212, wikipedia, wiki, book, books, library,

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