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Euphorbia peplus

Euphorbia peplus (petty spurge,[1][2] radium weed,[2] cancer weed,[2] or milkweed),[2] is a species of Euphorbia, native to most of Europe, northern Africa and western Asia, where it typically grows in cultivated arable land, gardens and other disturbed land.[1][3][4]

Euphorbia peplus
Scientific classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Malpighiales
Family: Euphorbiaceae
Genus: Euphorbia
Species:
E. peplus
Binomial name
Euphorbia peplus

Outside of its native range it is very widely naturalised and often invasive, including in Australia, New Zealand, North America and other countries in temperate and sub-tropical regions.[1]

Description edit

It is an annual plant growing to 5–30 cm (2–12 in) tall (most plants growing as weeds of cultivation tend towards the smaller end), with smooth hairless stems. The leaves are stalked, oval-acute, 1–3 cm (0.4–1.2 in) long, with untoothed margin. It has green flowers in three-rayed umbels. The glands typically of Euphorbia are kidney-shaped, and have long thin horns.[4]

var. minima has stems low, ascending, branchy, leaves roundish, seeds smaller 1-1.4 mm (vs. 1.3-1.6 mm of var. peplus),[5] predominantly countries on the north edge of the Mediterranean (PoWo Map)

 
Euphorbia peplus cyathium

Medicinal uses edit

The plant's sap is toxic to rapidly replicating human tissue, and has long been used as a traditional remedy for common skin lesions.[6] The active ingredient in the sap is a diterpene ester called ingenol mebutate.

A pharmaceutical-grade ingenol mebutate gel has approval from the US Food and Drug Administration for treatment of actinic keratosis.[6][7][8]

In Germany, recent studies have linked Euphorbia peplus with the virtual elimination of squamous cell skin cancer.[9]

References edit

  1. ^ a b c "Euphorbia peplus". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 2 January 2018.
  2. ^ a b c d Hazel Dempster; Bronwen Keighery; Greg Keighery; Rod Randall; Bob Dixon; Bill Betts; Margo O'Byrne; Diane Matthews. (PDF). Archived from the original (PDF) on 2009-10-25.
  3. ^ Flora Europaea: Euphorbia peplus
  4. ^ a b Blamey, M. & Grey-Wilson, C. (1989). Flora of Britain and Northern Europe. ISBN 0-340-40170-2
  5. ^ Davis. Flora of Turkey and the East Aegean Islands, vol. 7.
  6. ^ a b Siller G, Gebauer K, Welburn P, Katsamas J, Ogbourne SM (2009). "PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study". Australasian Journal of Dermatology. 50 (1): 16–22. doi:10.1111/j.1440-0960.2008.00497.x. PMID 19178487. S2CID 19308099.
  7. ^ Lebwohl, M, et al. "Ingenol Mebutate Gel for Actinic Keratosis." N Engl J Med 366;11, March 15, 2012.
  8. ^ . eMedicine. Yahoo! Finance. January 25, 2012. Archived from the original on February 10, 2012.
  9. ^ Braun, S.A.; Homey, B.; Gerber, P.A. (October 2014). "Erfolgreiche Behandlung eines Morbus Bowen mit Ingenolmebutat". Der Hautarzt (in German). 65 (10): 848–850. doi:10.1007/s00105-014-3509-5. ISSN 0017-8470. PMID 25217087.

External links edit

euphorbia, peplus, confused, with, euphorbia, peplis, purple, spurge, relatively, rare, plant, coastal, sand, shingle, petty, spurge, radium, weed, cancer, weed, milkweed, species, euphorbia, native, most, europe, northern, africa, western, asia, where, typica. Not to be confused with Euphorbia peplis Purple spurge a relatively rare plant of coastal sand and shingle Euphorbia peplus petty spurge 1 2 radium weed 2 cancer weed 2 or milkweed 2 is a species of Euphorbia native to most of Europe northern Africa and western Asia where it typically grows in cultivated arable land gardens and other disturbed land 1 3 4 Euphorbia peplus Scientific classification Kingdom Plantae Clade Tracheophytes Clade Angiosperms Clade Eudicots Clade Rosids Order Malpighiales Family Euphorbiaceae Genus Euphorbia Species E peplus Binomial name Euphorbia peplusL Outside of its native range it is very widely naturalised and often invasive including in Australia New Zealand North America and other countries in temperate and sub tropical regions 1 Contents 1 Description 2 Medicinal uses 3 References 4 External linksDescription editIt is an annual plant growing to 5 30 cm 2 12 in tall most plants growing as weeds of cultivation tend towards the smaller end with smooth hairless stems The leaves are stalked oval acute 1 3 cm 0 4 1 2 in long with untoothed margin It has green flowers in three rayed umbels The glands typically of Euphorbia are kidney shaped and have long thin horns 4 var minima has stems low ascending branchy leaves roundish seeds smaller 1 1 4 mm vs 1 3 1 6 mm of var peplus 5 predominantly countries on the north edge of the Mediterranean PoWo Map nbsp Euphorbia peplus cyathiumMedicinal uses editThe plant s sap is toxic to rapidly replicating human tissue and has long been used as a traditional remedy for common skin lesions 6 The active ingredient in the sap is a diterpene ester called ingenol mebutate A pharmaceutical grade ingenol mebutate gel has approval from the US Food and Drug Administration for treatment of actinic keratosis 6 7 8 In Germany recent studies have linked Euphorbia peplus with the virtual elimination of squamous cell skin cancer 9 References edit a b c Euphorbia peplus Germplasm Resources Information Network Agricultural Research Service United States Department of Agriculture Retrieved 2 January 2018 a b c d Hazel Dempster Bronwen Keighery Greg Keighery Rod Randall Bob Dixon Bill Betts Margo O Byrne Diane Matthews Euphorbia terracina Workshop Proceedings 2000 PDF Archived from the original PDF on 2009 10 25 Flora Europaea Euphorbia peplus a b Blamey M amp Grey Wilson C 1989 Flora of Britain and Northern Europe ISBN 0 340 40170 2 Davis Flora of Turkey and the East Aegean Islands vol 7 a b Siller G Gebauer K Welburn P Katsamas J Ogbourne SM 2009 PEP005 ingenol mebutate gel a novel agent for the treatment of actinic keratosis results of a randomized double blind vehicle controlled multicentre phase IIa study Australasian Journal of Dermatology 50 1 16 22 doi 10 1111 j 1440 0960 2008 00497 x PMID 19178487 S2CID 19308099 Lebwohl M et al Ingenol Mebutate Gel for Actinic Keratosis N Engl J Med 366 11 March 15 2012 FDA Approves Picato ingenol mebutate Gel the First and Only Topical Actinic Keratosis AK Therapy With 2 or 3 Consecutive Days of Once Daily Dosing eMedicine Yahoo Finance January 25 2012 Archived from the original on February 10 2012 Braun S A Homey B Gerber P A October 2014 Erfolgreiche Behandlung eines Morbus Bowen mit Ingenolmebutat Der Hautarzt in German 65 10 848 850 doi 10 1007 s00105 014 3509 5 ISSN 0017 8470 PMID 25217087 External links edit nbsp Wikimedia Commons has media related to Euphorbia peplus Euphorbia peplus in the CalPhotos photo database University of California Berkeley Retrieved from https en wikipedia org w index php title Euphorbia peplus amp oldid 1192665843, wikipedia, wiki, book, books, library,

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