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Wikipedia

Kopexil

Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.

Kopexil
Names
IUPAC names
2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine
2,4-Diaminopyrimidine 3-N-oxide
Other names
Aminexil
Identifiers
  • 113275-13-1 Y
  • 74638-76-9 (pyridine oxide tautomer) Y
3D model (JSmol)
  • Interactive image
ChemSpider
  • 10445922
EC Number
  • 616-121-2
  • 10197687
UNII
  • 1756681479
  • InChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2H,5H2,(H2,6,7)
    Key: SGHQFNHCCOBUKB-UHFFFAOYSA-N
  • InChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2,6,9H,5H2
    Key: YTKGAYFHUZTLCI-UHFFFAOYSA-N
  • c1cnc([n+](c1N)[O-])N
Properties
C4H6N4O
Molar mass 126.119 g·mol−1
Appearance white odorless crystals[1]
Melting point 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1]
slightly soluble[1]
Hazards
GHS labelling:
Warning
H302
P264, P270, P301+P312, P330, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)

Chemical structure

Kopexil is an N-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.

Mechanism of action

The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]

References

  1. ^ a b c MSDS for Kopexil at Kumar Organics. 2015-07-22 at the Wayback Machine March 28th 2012.
  2. ^ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
  3. ^ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).



kopexil, inci, name, diaminopyrimidine, oxide, trade, name, aminexil, chemical, compound, similar, minoxidil, minoxidil, originally, used, treat, high, blood, pressure, side, effect, increased, body, hair, both, compounds, have, been, used, therapy, alopecia, . Kopexil INCI name diaminopyrimidine oxide trade name Aminexil is a chemical compound similar to minoxidil Minoxidil was originally used to treat high blood pressure a side effect was increased body hair Both compounds have been used for therapy of alopecia 2 Kopexil is not approved for use as a drug in the United States or in Europe Kopexil NamesIUPAC names 2 3 Dihydro 3 hydroxy 2 imino 4 pyrimidinamine2 4 Diaminopyrimidine 3 N oxideOther names AminexilIdentifiersCAS Number 113275 13 1 Y74638 76 9 pyridine oxide tautomer Y3D model JSmol Interactive imageChemSpider 10445922EC Number 616 121 2PubChem CID 10197687UNII 1756681479InChI InChI 1S C4H6N4O c5 3 1 2 7 4 6 8 3 9 h1 2H 5H2 H2 6 7 Key SGHQFNHCCOBUKB UHFFFAOYSA NInChI 1S C4H6N4O c5 3 1 2 7 4 6 8 3 9 h1 2 6 9H 5H2Key YTKGAYFHUZTLCI UHFFFAOYSA NSMILES c1cnc n c1N O NPropertiesChemical formula C 4H 6N 4OMolar mass 126 119 g mol 1Appearance white odorless crystals 1 Melting point 210 to 218 C 410 to 424 F 483 to 491 K 1 Solubility in water slightly soluble 1 HazardsGHS labelling PictogramsSignal word WarningHazard statements H302Precautionary statements P264 P270 P301 P312 P330 P501Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Y verify what is Y N Infobox referencesChemical structure EditKopexil is an N oxide a group of substances in which the nitrogen atom of a tertiary amine is oxidized The compound can exist in two tautomeric forms Mechanism of action EditThe exact mechanism of action of kopexil is unknown There is no proof of therapeutic effect for kopexil against alopecia 3 References Edit a b c MSDS for Kopexil at Kumar Organics Archived 2015 07 22 at the Wayback Machine March 28th 2012 Trueb RM de Viragh PA Status of scalp hair and therapy of alopecia in men in Switzerland PMID 11256223 Wolfgang Raab Haarerkrankungen in der dermatologischen Praxis p 82 at Google Books German This antihypertensive related article is a stub You can help Wikipedia by expanding it vte This dermatologic drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Kopexil amp oldid 1105215209, wikipedia, wiki, book, books, library,

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