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Wikipedia

Surgisphere

January 07, 2023

Surgisphere is an American healthcare analytics company established in 2008 by Sapan Desai. Originally a textbook marketing company, it came under scrutiny in May 2020 after it provided large datasets of COVID-19 patients that were subsequently found to be unreliable. The questionable data were used in studies published in The Lancet and The New England Journal of Medicine in May 2020, suggesting that COVID-19 patients on hydroxychloroquine had a "significantly higher risk of death". In light of these studies, the World Health Organization decided to temporarily halt global trials of the drug hydroxychloroquine to treat COVID-19. After the studies were retracted, the WHO trials were resumed and then discontinued shortly after.

Surgisphere
TypePrivate
IndustryHealthcare analytics
Founded2008[1]
Headquarters
Palatine, Illinois
,
US[2]
Key people
Sapan Desai (CEO and founder)
Number of employees
11
Websitesurgisphere.com[dead link]

History

Surgisphere was established in 2008[1] by Sapan Desai, then a medical resident, to market medical textbooks to medical students. Fake five-star reviews on Amazon from accounts impersonating actual physicians were found.[3] Desai became a vascular surgeon and worked at Northwest Community Hospital.[4][5][6]

Surgisphere had three subsidiaries: Surgical Outcomes Collaborative, Vascular Outcomes and Quartz Clinical.[5] From 2010 to 2013 it published an online medical journal, the Journal of Surgical Radiology.[2][5] It ceased publication despite having claimed to accrue 50,000 subscribers because Desai "ran out of time".[3]

In June 2020 Desai's spokesperson said Surgisphere had 11 employees and had been compiling a global hospital records database since 2008.[7] In its promotional material and press releases, Surgisphere claimed to have a cloud-based healthcare data analytics platform and to be "leveraging... its global research network and advanced machine learning" using decision tree analysis.[8]

After the retractions of two studies in June 2020, company social media accounts were deleted,[9] and on 15 June 2020, the company website was taken offline.[10]

COVID-19 misconduct

Further information: Chloroquine and hydroxychloroquine during the COVID-19 pandemic § WHO trial

Diagnostic tool

Starting in March 2020, Surgisphere promoted a "rapid diagnostic tool" for COVID-19, which it said was in use by over 1000 hospitals.[11][12] The African Federation for Emergency Medicine (AFEM) had promoted the COVID-19 Severity Scoring Tool for use in 26 countries and some institutions had started validation studies. On 5 June 2020, following the scandal about the Lancet and NEJM articles, AFEM recommended that the tool no longer be used.[13]

Ivermectin preprint

In April 2020, Desai et al. published a paper based on purported Surgisphere data which suggested ivermectin reduced COVID-19 mortality.[14] It was described as a "retrospective matched-control study of coronavirus patients using a real-time hospitalization database". It was published as a preprint but was retracted at the end of May.[15][16][17] Several Latin American government health organizations recommended ivermectin as a COVID-19 treatment based, in part, on this preprint; these recommendations were later denounced by the Pan American Health Organization.[17][18]

Lancet and NEJM articles

Surgisphere provided dubious data used for studies of COVID-19 that were published in The Lancet[19] and The New England Journal of Medicine (NEJM) in May 2020.[20][21] The Lancet study claimed that the dataset of hospital records showed that patients taking hydroxychloroquine were more likely to die in hospital, and prompted the World Health Organization to halt global trials of the drug to treat COVID-19.[4][14][22] The NEJM study claimed that hospital data records showed that COVID-19 patients were not harmed by treatment with ACE inhibitors and angiotensin-receptor blockers.[20][23][24]

The dataset from the alleged 1200 hospitals had many errors, including the listing of an Asian hospital as being in Australia, and no indications of how Surgisphere could collect the data, and was widely criticised.[25][26][27][4] As a result, on 28 May over 200 researchers and doctors from various countries published "An open letter to Richard Horton, editor-in-chief of The Lancet, regarding Mehra et al", stating "Both the numbers of cases and deaths, and the detailed data collection, seem unlikely."[28] Science Magazine said critics had "pointed out many red flags in the Lancet paper, including the astonishing number of patients involved and details about their demographics and prescribed dosing that seem implausible."[14][20] One of the signatories, Adrian Hernandez of the Duke Clinical Research Institute, said "the biggest thing that raised a red flag was that there was such a large database across more than 600 hospitals, and no one had really known about its existence".[29]

On 3 June 2020, The Lancet and the NEJM released online "expressions of concern" about the published studies,[30][31] and on 4 June the Lancet paper was retracted by Mehra, Ruschitzka, and Amit Patel, all authors except Desai. In their retraction, the three wrote Surgisphere had not transferred "the full dataset, client contracts, and the full ISO audit report to their servers for analysis as such transfer would violate client agreements and confidentiality requirements", preventing reviewers from conducting an independent and private peer review. The three authors said:

"We can never forget the responsibility we have as researchers to scrupulously ensure that we rely on data sources that adhere to our high standards. Based on this development, we can no longer vouch for the veracity of the primary data sources. Due to this unfortunate development, the authors request that the paper be retracted."[32]

On 4 June, The Lancet retracted the study,[33][34] as did the NEJM.[35][16][36] In the meantime, on 3 June, the WHO resumed its hydroxychloroquine drug trials.[37]

On 6 June 2020, NHS Scotland told the Financial Times that they had "no current or past contractual arrangement" with Surgisphere, nor was the company an approved supplier, nor had it ever had access to data, despite Surgisphere stating it had "collaborated" with the NHS. Surgisphere's website had a picture of Queen Elizabeth University Hospital, an NHS hospital in Glasgow.[38]

On 7 June 2020, fellow author Amit Patel's position with the University of Utah was terminated over the journal retractions. Patel is Desai's brother-in-law.[39]

Richard Horton, editor-in-chief of The Lancet, called the paper "a fabrication" and "a monumental fraud". Eric Rubin, editor-in-chief of NEJM, said "We shouldn’t have published this".[40]

General legitimacy

A July 2020 article in New York Times described an employee extracting data manually to create a spreadsheet for Surgisphere's QuartzClinical. She was "surprised" by claims of a massive data store, stating she knew of only a single hospital that had signed a contract with the company; the May 1 paper in NEJM claimed to use data from 169 hospitals across the globe, and the May 22 paper in The Lancet.[41]

A parallel investigation by the British newspaper The Guardian revealed that several of Surgisphere's employees had little or no scientific background; one employee appeared to be a science fiction author while another, listed as a marketing executive, was an adult model. The Guardian also found that Surgisphere's LinkedIn page has fewer than 100 followers and in late May 2020 listed only six employees. It also found that the company had almost no online presence and that its Twitter account had made no posts from October 2017 to March 2020.[20]

Elisabeth Bik et al. analyzed one of Desai's early first author papers and found apparent evidence of image manipulation.[42][43]

References

  1. ^ a b "Surgisphere Corp". Bloomberg. Retrieved 11 June 2020.
  2. ^ a b Offord, Catherine (30 May 2020). . The Scientist. Archived from the original on 3 June 2020. Retrieved 3 June 2020.
  3. ^ a b Catherine Offord (2020-05-30). "Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere". The Scientist Magazine®. Retrieved 2020-06-08.
  4. ^ a b c Davey, Melissa (28 May 2020). "Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid-19". Guardian. Retrieved 3 June 2020.
  5. ^ a b c Todaro, James (29 May 2020). "A Study Out of Thin Air". MedicineUncensored. Retrieved 3 June 2020. Dr. Desai appears to be the founder of Surgisphere, which was formed in 2007. A PubMed search for “Sapan Desai” shows 39 medical publications in the last five years. With the exception of the two very recent COVID-19 papers, the Surgisphere database does not appear to have been used in any of the other 37 publications. Why would the founder of Surgisphere have access to one of the largest repositories of real-time patient data, but not use it until publishing on COVID-19? If we ignore the image of multiple shell corporations enshrouding a hastily organized Surgisphere Corporation and stick to analyzing the COVID-19 data from the Lancet study, the findings are even less reassuring.
  6. ^ "Dr Sapan Desai, United States of America". World Hospital Congress. Iceberg events. Retrieved 3 June 2020. Sapan Desai, MD, PhD, MBA is President and Chief Executive Officer of the Surgisphere Corporation, a medical education and healthcare data analytics company with hundreds of clients around the world. He has held multiple physician leadership roles in clinical practice, including serving as the Vice Chairman for Research at Southern Illinois University, Director of Quality at Memorial Medical Center, and Director of Performance Improvement at Northwest Community Hospital. Dr. Desai is a certified lean six sigma master black belt, and a certified professional in healthcare quality. He is the recipient of the international grand prize in healthcare quality by the International Hospital Federation in 2015.
  7. ^ Servick, Kelly; Enserink, Martin (2020-06-05). "The pandemic's first major research scandal erupts". Science. Vol. 368, no. 6495. pp. 1041–1042. doi:10.1126/science.368.6495.1041. ISSN 0036-8075. PMID 32499418. Retrieved 2020-07-07.
  8. ^ Zaidisays, Al (2020-05-27). "Surgisphere's COVID-19 Tools are Deadly Fraud". Retrieved 2020-07-07.
  9. ^ Hopkins, Jared S.; Gold, Russell (11 June 2020). "The Big-Data Mystery Behind Retracted Covid-19 Studies of Hydroxychloroquine, Other Drugs". Wall Street Journal. Retrieved 17 June 2020.
  10. ^ Owermohle, Sarah (16 June 2020). "Hydroxychloroquine is out". Politico. Retrieved 17 June 2020.
  11. ^ Offord, Catherine (30 May 2020). "Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere". The Scientist Magazine®. Retrieved 3 June 2020. James Watson, a senior scientist at the Mahidol Oxford Tropical Medicine Research Unit in Thailand, says he has doubts that any research organization would have been able to obtain such detailed records for so many people in Africa so quickly. He outlined this and concerns about multiple other aspects of the study in the open letter, which includes 17 signatories based at institutions in Africa.
  12. ^ James Watson [@jwato_watson] (27 May 2020). "As you might expect, it's a different story... conclusion: a prediction tool that is basically just linear regression and estimates age-dependent mortality that conflicts with a very large and reliable (we know where the data came from!) study. Wonderful AI/ML companies..!(6/n)" (Tweet) – via Twitter.
  13. ^ Offord, Catherine (7 June 2020). "Surgisphere Fallout Hits African Nonprofit's COVID-19 Efforts". The Scientist Magazine. Retrieved 19 June 2020.
  14. ^ a b c Servick, Kelly; Enserink, Martin (2 June 2020). "A mysterious company's coronavirus papers in top medical journals may be unraveling". Science. AAAS. Retrieved June 3, 2020.
  15. ^ Lowe, Derek (11 May 2020). "What's Up With Ivermectin?". science.com. Retrieved 4 June 2020.
  16. ^ a b Piller, Charles; Servick, Kelly (4 June 2020). "Two elite medical journals retract coronavirus papers over data integrity questions". Science. Retrieved 5 June 2020.
  17. ^ a b "Surgisphere Sows Confusion About Another Unproven COVID-19 Drug". The Scientist Magazine®. 2020-06-16. Retrieved 2020-07-09.
  18. ^ "Lancet, NEJM Retract Surgisphere Studies on COVID-19 Patients". The Scientist Magazine®. Retrieved 2021-07-23.
  19. ^ Mehra, MR; Desai, SS; Ruschitzka, F; Patel, AN (May 2020). "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis". Lancet. doi:10.1016/S0140-6736(20)31180-6. PMC 7255293. PMID 32450107. Lay source (Retracted, see  [1])
  20. ^ a b c d Davey, Melissa; Kirchgaessner, Stephanie; Boseley, Sarah (3 June 2020). "Governments and WHO changed Covid-19 policy based on suspect data from tiny US company". Guardian. Retrieved 3 June 2020.
  21. ^ Piller, Charles (2020-06-08). "Who's to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal". Science | AAAS. Retrieved 2021-07-23.
  22. ^ "Was the Surgisphere case a one-off, or does it highlight the bigger systemic problem of research fraud?". Transparency International UK. Retrieved 2021-07-23.
  23. ^ "Could the Surgisphere Retractions Debacle Happen Again?". Medscape. Retrieved 2021-07-23.
  24. ^ "Surgisphere Data Used in Two COVID Studies Called Into Question". www.medpagetoday.com. 2020-06-03. Retrieved 2021-07-23.
  25. ^ Mehra, M. R.; Desai, S. S.; Ruschitzka, F.; Patel, A. N. (2020). "PubPeer - Hydroxychloroquine or chloroquine with or without a macrolid..." Lancet. doi:10.1016/s0140-6736(20)31180-6. ISSN 0140-6736. PMC 7255293. PMID 32450107. Retrieved 3 June 2020.
  26. ^ Gelman, Andrew (24 May 2020). "Doubts about that article claiming that hydroxychloroquine/chloroquine is killing people « Statistical Modeling, Causal Inference, and Social Science". statmodeling.stat.columbia.edu. Retrieved 3 June 2020.
  27. ^ Gelman, Andrew (25 May 2020). "Hydroxychloroquine update: Statistical Modeling, Causal Inference, and Social Science". statmodeling.stat.columbia.edu. Retrieved 3 June 2020.
  28. ^ James Watson On The Behalf Of 201 Signatories (2020). "An open letter to Mehra et al and The Lancet". Zenodo. doi:10.5281/zenodo.3871094. Retrieved 5 June 2020.
  29. ^ Roni Caryn Rabin (29 May 2020). "Scientists Question Validity of Major Hydroxychloroquine Study". The New York Times. Retrieved 3 June 2020. The experts who wrote The Lancet also criticized the study’s methodology and the authors’ refusal to identify any of the hospitals that contributed patient data, or to name the countries where they were located. The company that owns the database is Surgisphere, based in Chicago.
  30. ^ The Lancet Editors (3 June 2020). "Expression of concern: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis". The Lancet. 395 (10240): e102. doi:10.1016/S0140-6736(20)31290-3. PMC 7269709. PMID 32504543. {{cite journal}}: |last1= has generic name (help)
  31. ^ Rubin M.D, Ph.D, Eric J. (2 June 2020). "Expression of Concern: Mehra MR et al. Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19". New England Journal of Medicine. 382 (25): 2464. doi:10.1056/NEJMe2020822. PMC 7269012. PMID 32484612. S2CID 219174075.
  32. ^ Mehra MR, Ruschitzka F, Patel AN (June 2020). "Retraction: "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"". Lancet. 395 (10240): 1820. doi:10.1016/S0140-6736(20)31324-6. PMC 7274621. PMID 32511943.
  33. ^ Mehra, Mandeep R.; Ruschitzka, Frank; Patel, Amit N. (4 June 2020). "Retraction: "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"". The Lancet. 395 (10240): 1820. doi:10.1016/S0140-6736(20)31324-6. PMC 7274621. PMID 32511943.
  34. ^ Boseley, Sarah; Davey, Melissa (4 June 2020). "Covid-19: Lancet retracts paper that halted hydroxychloroquine trials". The Guardian. Retrieved 4 June 2020.
  35. ^ Mehra, Mandeep R.; Desai, Sapan S.; Kuy, Sreyram; Henry, Timothy D.; Patel, Amit N. (4 June 2020). "Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621". The New England Journal of Medicine. 382 (26): 2582. doi:10.1056/NEJMc2021225. PMC 7274164. PMID 32501665.
  36. ^ Hopkins, Jared S.; Gold, Russell (4 June 2020). "Hydroxychloroquine Studies Tied to Data Firm Surgisphere Retracted". The Wall Street Journal. Retrieved 5 June 2020.
  37. ^ Mancini, Donato Paolo; Kuchler, Hannah (3 June 2020). "WHO restarts drug trial as doubts grow over clinical data". Financial Times. Retrieved 5 June 2020.
  38. ^ Mure Dickie; Donato Paolo Mancini; Hannah Kuchler (6 June 2020). "Edinburgh disavows Surgisphere claims of co-operation with NHS Scotland". Financial Times. Retrieved 8 June 2020.
  39. ^ Matthew Herper; Kate Sheridan (7 June 2020). "Researcher has faculty appointment terminated after Lancet retraction". STAT. Retrieved 8 June 2020. The University of Utah has “mutually agreed” to terminate the faculty appointment of Amit Patel, who was among the authors of two retracted papers on Covid-19 and who appears to have played a key role in involving a little-known company that has ignited a firestorm of controversy.
  40. ^ Roni Caryn Rabin (14 June 2020). "The Pandemic Claims New Victims: Prestigious Medical Journals". The New York Times. Retrieved 18 June 2020.
  41. ^ Ellen Gabler; Roni Caryn Rabin (27 July 2020). "The Doctor Behind the Disputed Covid Data". The New York Times. Retrieved 27 July 2020.
  42. ^ The Surgisphere Founder and the Melba Toast figure, Science Integrity Digest, June 6, 2020.
  43. ^ Davey, Melissa; Kirchgaessner, Stephanie (2020-06-10). "Surgisphere: mass audit of papers linked to firm behind hydroxychloroquine Lancet study scandal". the Guardian. Retrieved 2020-06-10.

External links

  • LinkedIn Page
  • Sapan Desai interview about the studies on TRT World
  • Surgisphere scandal: Lancet still doesn’t get it by Andrew Gelman

January 07, 2023
surgisphere, american, healthcare, analytics, company, established, 2008, sapan, desai, originally, textbook, marketing, company, came, under, scrutiny, 2020, after, provided, large, datasets, covid, patients, that, were, subsequently, found, unreliable, quest. Surgisphere is an American healthcare analytics company established in 2008 by Sapan Desai Originally a textbook marketing company it came under scrutiny in May 2020 after it provided large datasets of COVID 19 patients that were subsequently found to be unreliable The questionable data were used in studies published in The Lancet and The New England Journal of Medicine in May 2020 suggesting that COVID 19 patients on hydroxychloroquine had a significantly higher risk of death In light of these studies the World Health Organization decided to temporarily halt global trials of the drug hydroxychloroquine to treat COVID 19 After the studies were retracted the WHO trials were resumed and then discontinued shortly after SurgisphereTypePrivateIndustryHealthcare analyticsFounded2008 1 HeadquartersPalatine Illinois US 2 Key peopleSapan Desai CEO and founder Number of employees11Websitesurgisphere wbr com dead link Contents 1 History 2 COVID 19 misconduct 2 1 Diagnostic tool 2 2 Ivermectin preprint 2 3 Lancet and NEJM articles 3 General legitimacy 4 References 5 External linksHistory EditSurgisphere was established in 2008 1 by Sapan Desai then a medical resident to market medical textbooks to medical students Fake five star reviews on Amazon from accounts impersonating actual physicians were found 3 Desai became a vascular surgeon and worked at Northwest Community Hospital 4 5 6 Surgisphere had three subsidiaries Surgical Outcomes Collaborative Vascular Outcomes and Quartz Clinical 5 From 2010 to 2013 it published an online medical journal the Journal of Surgical Radiology 2 5 It ceased publication despite having claimed to accrue 50 000 subscribers because Desai ran out of time 3 In June 2020 Desai s spokesperson said Surgisphere had 11 employees and had been compiling a global hospital records database since 2008 7 In its promotional material and press releases Surgisphere claimed to have a cloud based healthcare data analytics platform and to be leveraging its global research network and advanced machine learning using decision tree analysis 8 After the retractions of two studies in June 2020 company social media accounts were deleted 9 and on 15 June 2020 the company website was taken offline 10 COVID 19 misconduct EditFurther information Chloroquine and hydroxychloroquine during the COVID 19 pandemic WHO trial Diagnostic tool Edit Starting in March 2020 Surgisphere promoted a rapid diagnostic tool for COVID 19 which it said was in use by over 1000 hospitals 11 12 The African Federation for Emergency Medicine AFEM had promoted the COVID 19 Severity Scoring Tool for use in 26 countries and some institutions had started validation studies On 5 June 2020 following the scandal about the Lancet and NEJM articles AFEM recommended that the tool no longer be used 13 Ivermectin preprint Edit In April 2020 Desai et al published a paper based on purported Surgisphere data which suggested ivermectin reduced COVID 19 mortality 14 It was described as a retrospective matched control study of coronavirus patients using a real time hospitalization database It was published as a preprint but was retracted at the end of May 15 16 17 Several Latin American government health organizations recommended ivermectin as a COVID 19 treatment based in part on this preprint these recommendations were later denounced by the Pan American Health Organization 17 18 Lancet and NEJM articles Edit Surgisphere provided dubious data used for studies of COVID 19 that were published in The Lancet 19 and The New England Journal of Medicine NEJM in May 2020 20 21 The Lancet study claimed that the dataset of hospital records showed that patients taking hydroxychloroquine were more likely to die in hospital and prompted the World Health Organization to halt global trials of the drug to treat COVID 19 4 14 22 The NEJM study claimed that hospital data records showed that COVID 19 patients were not harmed by treatment with ACE inhibitors and angiotensin receptor blockers 20 23 24 The dataset from the alleged 1200 hospitals had many errors including the listing of an Asian hospital as being in Australia and no indications of how Surgisphere could collect the data and was widely criticised 25 26 27 4 As a result on 28 May over 200 researchers and doctors from various countries published An open letter to Richard Horton editor in chief of The Lancet regarding Mehra et al stating Both the numbers of cases and deaths and the detailed data collection seem unlikely 28 Science Magazine said critics had pointed out many red flags in the Lancet paper including the astonishing number of patients involved and details about their demographics and prescribed dosing that seem implausible 14 20 One of the signatories Adrian Hernandez of the Duke Clinical Research Institute said the biggest thing that raised a red flag was that there was such a large database across more than 600 hospitals and no one had really known about its existence 29 On 3 June 2020 The Lancet and the NEJM released online expressions of concern about the published studies 30 31 and on 4 June the Lancet paper was retracted by Mehra Ruschitzka and Amit Patel all authors except Desai In their retraction the three wrote Surgisphere had not transferred the full dataset client contracts and the full ISO audit report to their servers for analysis as such transfer would violate client agreements and confidentiality requirements preventing reviewers from conducting an independent and private peer review The three authors said We can never forget the responsibility we have as researchers to scrupulously ensure that we rely on data sources that adhere to our high standards Based on this development we can no longer vouch for the veracity of the primary data sources Due to this unfortunate development the authors request that the paper be retracted 32 On 4 June The Lancet retracted the study 33 34 as did the NEJM 35 16 36 In the meantime on 3 June the WHO resumed its hydroxychloroquine drug trials 37 On 6 June 2020 NHS Scotland told the Financial Times that they had no current or past contractual arrangement with Surgisphere nor was the company an approved supplier nor had it ever had access to data despite Surgisphere stating it had collaborated with the NHS Surgisphere s website had a picture of Queen Elizabeth University Hospital an NHS hospital in Glasgow 38 On 7 June 2020 fellow author Amit Patel s position with the University of Utah was terminated over the journal retractions Patel is Desai s brother in law 39 Richard Horton editor in chief of The Lancet called the paper a fabrication and a monumental fraud Eric Rubin editor in chief of NEJM said We shouldn t have published this 40 General legitimacy EditA July 2020 article in New York Times described an employee extracting data manually to create a spreadsheet for Surgisphere s QuartzClinical She was surprised by claims of a massive data store stating she knew of only a single hospital that had signed a contract with the company the May 1 paper in NEJM claimed to use data from 169 hospitals across the globe and the May 22 paper in The Lancet 41 A parallel investigation by the British newspaper The Guardian revealed that several of Surgisphere s employees had little or no scientific background one employee appeared to be a science fiction author while another listed as a marketing executive was an adult model The Guardian also found that Surgisphere s LinkedIn page has fewer than 100 followers and in late May 2020 listed only six employees It also found that the company had almost no online presence and that its Twitter account had made no posts from October 2017 to March 2020 20 Elisabeth Bik et al analyzed one of Desai s early first author papers and found apparent evidence of image manipulation 42 43 References Edit a b Surgisphere Corp Bloomberg Retrieved 11 June 2020 a b Offord Catherine 30 May 2020 Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere The Scientist Archived from the original on 3 June 2020 Retrieved 3 June 2020 a b Catherine Offord 2020 05 30 Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere The Scientist Magazine Retrieved 2020 06 08 a b c Davey Melissa 28 May 2020 Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid 19 Guardian Retrieved 3 June 2020 a b c Todaro James 29 May 2020 A Study Out of Thin Air MedicineUncensored Retrieved 3 June 2020 Dr Desai appears to be the founder of Surgisphere which was formed in 2007 A PubMed search for Sapan Desai shows 39 medical publications in the last five years With the exception of the two very recent COVID 19 papers the Surgisphere database does not appear to have been used in any of the other 37 publications Why would the founder of Surgisphere have access to one of the largest repositories of real time patient data but not use it until publishing on COVID 19 If we ignore the image of multiple shell corporations enshrouding a hastily organized Surgisphere Corporation and stick to analyzing the COVID 19 data from the Lancet study the findings are even less reassuring Dr Sapan Desai United States of America World Hospital Congress Iceberg events Retrieved 3 June 2020 Sapan Desai MD PhD MBA is President and Chief Executive Officer of the Surgisphere Corporation a medical education and healthcare data analytics company with hundreds of clients around the world He has held multiple physician leadership roles in clinical practice including serving as the Vice Chairman for Research at Southern Illinois University Director of Quality at Memorial Medical Center and Director of Performance Improvement at Northwest Community Hospital Dr Desai is a certified lean six sigma master black belt and a certified professional in healthcare quality He is the recipient of the international grand prize in healthcare quality by the International Hospital Federation in 2015 Servick Kelly Enserink Martin 2020 06 05 The pandemic s first major research scandal erupts Science Vol 368 no 6495 pp 1041 1042 doi 10 1126 science 368 6495 1041 ISSN 0036 8075 PMID 32499418 Retrieved 2020 07 07 Zaidisays Al 2020 05 27 Surgisphere s COVID 19 Tools are Deadly Fraud Retrieved 2020 07 07 Hopkins Jared S Gold Russell 11 June 2020 The Big Data Mystery Behind Retracted Covid 19 Studies of Hydroxychloroquine Other Drugs Wall Street Journal Retrieved 17 June 2020 Owermohle Sarah 16 June 2020 Hydroxychloroquine is out Politico Retrieved 17 June 2020 Offord Catherine 30 May 2020 Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere The Scientist Magazine Retrieved 3 June 2020 James Watson a senior scientist at the Mahidol Oxford Tropical Medicine Research Unit in Thailand says he has doubts that any research organization would have been able to obtain such detailed records for so many people in Africa so quickly He outlined this and concerns about multiple other aspects of the study in the open letter which includes 17 signatories based at institutions in Africa James Watson jwato watson 27 May 2020 As you might expect it s a different story conclusion a prediction tool that is basically just linear regression and estimates age dependent mortality that conflicts with a very large and reliable we know where the data came from study Wonderful AI ML companies 6 n Tweet via Twitter Offord Catherine 7 June 2020 Surgisphere Fallout Hits African Nonprofit s COVID 19 Efforts The Scientist Magazine Retrieved 19 June 2020 a b c Servick Kelly Enserink Martin 2 June 2020 A mysterious company s coronavirus papers in top medical journals may be unraveling Science AAAS Retrieved June 3 2020 Lowe Derek 11 May 2020 What s Up With Ivermectin science com Retrieved 4 June 2020 a b Piller Charles Servick Kelly 4 June 2020 Two elite medical journals retract coronavirus papers over data integrity questions Science Retrieved 5 June 2020 a b Surgisphere Sows Confusion About Another Unproven COVID 19 Drug The Scientist Magazine 2020 06 16 Retrieved 2020 07 09 Lancet NEJM Retract Surgisphere Studies on COVID 19 Patients The Scientist Magazine Retrieved 2021 07 23 Mehra MR Desai SS Ruschitzka F Patel AN May 2020 Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID 19 a multinational registry analysis Lancet doi 10 1016 S0140 6736 20 31180 6 PMC 7255293 PMID 32450107 Lay source Retracted see 1 a b c d Davey Melissa Kirchgaessner Stephanie Boseley Sarah 3 June 2020 Governments and WHO changed Covid 19 policy based on suspect data from tiny US company Guardian Retrieved 3 June 2020 Piller Charles 2020 06 08 Who s to blame These three scientists are at the heart of the Surgisphere COVID 19 scandal Science AAAS Retrieved 2021 07 23 Was the Surgisphere case a one off or does it highlight the bigger systemic problem of research fraud Transparency International UK Retrieved 2021 07 23 Could the Surgisphere Retractions Debacle Happen Again Medscape Retrieved 2021 07 23 Surgisphere Data Used in Two COVID Studies Called Into Question www medpagetoday com 2020 06 03 Retrieved 2021 07 23 Mehra M R Desai S S Ruschitzka F Patel A N 2020 PubPeer Hydroxychloroquine or chloroquine with or without a macrolid Lancet doi 10 1016 s0140 6736 20 31180 6 ISSN 0140 6736 PMC 7255293 PMID 32450107 Retrieved 3 June 2020 Gelman Andrew 24 May 2020 Doubts about that article claiming that hydroxychloroquine chloroquine is killing people Statistical Modeling Causal Inference and Social Science statmodeling stat columbia edu Retrieved 3 June 2020 Gelman Andrew 25 May 2020 Hydroxychloroquine update Statistical Modeling Causal Inference and Social Science statmodeling stat columbia edu Retrieved 3 June 2020 James Watson On The Behalf Of 201 Signatories 2020 An open letter to Mehra et al and The Lancet Zenodo doi 10 5281 zenodo 3871094 Retrieved 5 June 2020 Roni Caryn Rabin 29 May 2020 Scientists Question Validity of Major Hydroxychloroquine Study The New York Times Retrieved 3 June 2020 The experts who wrote The Lancet also criticized the study s methodology and the authors refusal to identify any of the hospitals that contributed patient data or to name the countries where they were located The company that owns the database is Surgisphere based in Chicago The Lancet Editors 3 June 2020 Expression of concern Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID 19 a multinational registry analysis The Lancet 395 10240 e102 doi 10 1016 S0140 6736 20 31290 3 PMC 7269709 PMID 32504543 a href Template Cite journal html title Template Cite journal cite journal a last1 has generic name help Rubin M D Ph D Eric J 2 June 2020 Expression of Concern Mehra MR et al Cardiovascular Disease Drug Therapy and Mortality in Covid 19 New England Journal of Medicine 382 25 2464 doi 10 1056 NEJMe2020822 PMC 7269012 PMID 32484612 S2CID 219174075 Mehra MR Ruschitzka F Patel AN June 2020 Retraction Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID 19 a multinational registry analysis Lancet 395 10240 1820 doi 10 1016 S0140 6736 20 31324 6 PMC 7274621 PMID 32511943 Mehra Mandeep R Ruschitzka Frank Patel Amit N 4 June 2020 Retraction Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID 19 a multinational registry analysis The Lancet 395 10240 1820 doi 10 1016 S0140 6736 20 31324 6 PMC 7274621 PMID 32511943 Boseley Sarah Davey Melissa 4 June 2020 Covid 19 Lancet retracts paper that halted hydroxychloroquine trials The Guardian Retrieved 4 June 2020 Mehra Mandeep R Desai Sapan S Kuy Sreyram Henry Timothy D Patel Amit N 4 June 2020 Retraction Cardiovascular Disease Drug Therapy and Mortality in Covid 19 N Engl J Med DOI 10 1056 NEJMoa2007621 The New England Journal of Medicine 382 26 2582 doi 10 1056 NEJMc2021225 PMC 7274164 PMID 32501665 Hopkins Jared S Gold Russell 4 June 2020 Hydroxychloroquine Studies Tied to Data Firm Surgisphere Retracted The Wall Street Journal Retrieved 5 June 2020 Mancini Donato Paolo Kuchler Hannah 3 June 2020 WHO restarts drug trial as doubts grow over clinical data Financial Times Retrieved 5 June 2020 Mure Dickie Donato Paolo Mancini Hannah Kuchler 6 June 2020 Edinburgh disavows Surgisphere claims of co operation with NHS Scotland Financial Times Retrieved 8 June 2020 Matthew Herper Kate Sheridan 7 June 2020 Researcher has faculty appointment terminated after Lancet retraction STAT Retrieved 8 June 2020 The University of Utah has mutually agreed to terminate the faculty appointment of Amit Patel who was among the authors of two retracted papers on Covid 19 and who appears to have played a key role in involving a little known company that has ignited a firestorm of controversy Roni Caryn Rabin 14 June 2020 The Pandemic Claims New Victims Prestigious Medical Journals The New York Times Retrieved 18 June 2020 Ellen Gabler Roni Caryn Rabin 27 July 2020 The Doctor Behind the Disputed Covid Data The New York Times Retrieved 27 July 2020 The Surgisphere Founder and the Melba Toast figure Science Integrity Digest June 6 2020 Davey Melissa Kirchgaessner Stephanie 2020 06 10 Surgisphere mass audit of papers linked to firm behind hydroxychloroquine Lancet study scandal the Guardian Retrieved 2020 06 10 External links EditLinkedIn Page Sapan Desai interview about the studies on TRT World Surgisphere scandal Lancet still doesn t get it by Andrew Gelman Retrieved from https en wikipedia org w index php title Surgisphere amp oldid 1113743235, wikipedia, wiki, book, books, library,

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