Sulfanegen is an experimental antidote for cyanide poisoning.[1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective.[2] Instead, alternative chemicals such as sulfanegen, the hemithioacetal cyclic dimer of 3-MP, are being evaluated that produce 3-MP in vivo to compensate for the short half-life of 3-MP itself.[3]
Sulfanegen has been shown to be effective in animal studies.[4] It is being studied as the disodiumsalt, sulfanegen sodium,[3][5] and the triethanolamine salt, sulfanegen TEA.[6] One advantage various sulfanegen formulations have over existing treatments for acute cyanide poisoning is that they might be administered by intramuscular injection or orally[1] rather than by intravenous infusion.[6]
^Nagahara, N; Li, Q; Sawada, N (2003). "Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?". Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 3 (3): 198–204. doi:10.2174/1568008033340162. PMID 12871026.
^ abBrenner, M; Kim, JG; Lee, J; Mahon, SB; Lemor, D; Ahdout, R; Boss, GR; Blackledge, W; Jann, L; Nagasawa, HT; Patterson, SE (2010). "Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity". Toxicology and Applied Pharmacology. 248 (3): 269–76. doi:10.1016/j.taap.2010.08.002. PMC3382974. PMID 20705081.
^Chan, A; Crankshaw, DL; Monteil, A; Patterson, SE; Nagasawa, HT; Briggs, JE; Kozocas, JA; Mahon, SB; Brenner, M; Pilz, RB; Bigby, TD; Boss, GR (2011). "The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning". Clinical Toxicology. 49 (5): 366–73. doi:10.3109/15563650.2011.584879. PMC3882312. PMID 21740135.
^Belani, KG; Singh, H; Beebe, DS; George, P; Patterson, SE; Nagasawa, HT; Vince, R (2012). "Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium". Anesthesia and Analgesia. 114 (5): 956–61. doi:10.1213/ANE.0b013e31824c4eb5. PMC3334426. PMID 22392971.
^ ab"New Antidote for Cyanide Found". Yahoo News. February 1, 2013.
April 11, 2024
sulfanegen, experimental, antidote, cyanide, poisoning, being, studied, prodrug, mercaptopyruvic, acid, been, studied, potential, treatment, cyanide, poisoning, half, life, short, clinically, effective, instead, alternative, chemicals, such, sulfanegen, hemith. Sulfanegen is an experimental antidote for cyanide poisoning 1 It is being studied as a prodrug for 3 mercaptopyruvic acid 3 MP 3 MP has been studied as a potential treatment for cyanide poisoning but the half life is too short for it to be clinically effective 2 Instead alternative chemicals such as sulfanegen the hemithioacetal cyclic dimer of 3 MP are being evaluated that produce 3 MP in vivo to compensate for the short half life of 3 MP itself 3 Sulfanegen NamesIUPAC name 2 5 Dihydroxy 1 4 dithiane 2 5 dicarboxylic acidIdentifiersCAS Number 80003 64 1 Na salt Y1309654 46 33D model JSmol Interactive imageChEBI CHEBI 138170ChemSpider 29395474PubChem CID 24830990UNII 14338V25RC YInChI InChI 1S C6H8O6S2 c7 3 8 5 11 1 13 6 12 2 14 5 4 9 10 h11 12H 1 2H2 H 7 8 H 9 10 Key GYZMXMSJOZUNEQ UHFFFAOYSA NInChI 1 C6H8O6S2 c7 3 8 5 11 1 13 6 12 2 14 5 4 9 10 h11 12H 1 2H2 H 7 8 H 9 10 Key GYZMXMSJOZUNEQ UHFFFAOYAOSMILES C1C SCC S1 C O O O C O O OPropertiesChemical formula C 6H 8O 6S 2Molar mass 240 24 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references Sulfanegen has been shown to be effective in animal studies 4 It is being studied as the disodium salt sulfanegen sodium 3 5 and the triethanolamine salt sulfanegen TEA 6 One advantage various sulfanegen formulations have over existing treatments for acute cyanide poisoning is that they might be administered by intramuscular injection or orally 1 rather than by intravenous infusion 6 References edit a b Scientists Discover Fast Acting Cyanide Antidote Medgadget Dec 27 2007 Retrieved 2015 07 12 Nagahara N Li Q Sawada N 2003 Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification Current Drug Targets Immune Endocrine and Metabolic Disorders 3 3 198 204 doi 10 2174 1568008033340162 PMID 12871026 a b Brenner M Kim JG Lee J Mahon SB Lemor D Ahdout R Boss GR Blackledge W Jann L Nagasawa HT Patterson SE 2010 Sulfanegen sodium treatment in a rabbit model of sub lethal cyanide toxicity Toxicology and Applied Pharmacology 248 3 269 76 doi 10 1016 j taap 2010 08 002 PMC 3382974 PMID 20705081 Chan A Crankshaw DL Monteil A Patterson SE Nagasawa HT Briggs JE Kozocas JA Mahon SB Brenner M Pilz RB Bigby TD Boss GR 2011 The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning Clinical Toxicology 49 5 366 73 doi 10 3109 15563650 2011 584879 PMC 3882312 PMID 21740135 Belani KG Singh H Beebe DS George P Patterson SE Nagasawa HT Vince R 2012 Cyanide toxicity in juvenile pigs and its reversal by a new prodrug sulfanegen sodium Anesthesia and Analgesia 114 5 956 61 doi 10 1213 ANE 0b013e31824c4eb5 PMC 3334426 PMID 22392971 a b New Antidote for Cyanide Found Yahoo News February 1 2013 Retrieved from https en wikipedia org w index php title Sulfanegen amp oldid 1053086605, wikipedia, wiki, book, books, library,
