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Robert F. Furchgott

January 01, 1970

Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems.

Robert F. Furchgott
Born
Robert Francis Furchgott

June 4, 1916 (1916-06-04)
Charleston, South Carolina, U.S.
DiedMay 19, 2009(2009-05-19) (aged 92)
Seattle, Washington, U.S.
Alma mater
Spouse(s)Lenore Mandelbaum (1941–1983; her death; 3 children)
Margaret Gallagher Roth (?–2006; her death)
AwardsNobel Prize in Physiology or Medicine in 1998
Scientific career
FieldsBiochemistry
Institutions
Signature

Early life and education edit

Furchgott was born in Charleston, South Carolina, to Arthur Furchgott (December 1884 – January 1971), a department store owner, and Pena (Sorentrue) Furchgott. He graduated with from the University of North Carolina at Chapel Hill in 1937 with a degree in chemistry and went on to earn a Ph.D in biochemistry at Northwestern University in 1940.[1]

Career edit

 
Furchgott and other 1998 Nobel Prize winners with former U.S. President Bill Clinton, November 1998

Furchgott was faculty member and professor of pharmacology at Cornell University Medical College from 1940 to 1949, at Washington University School of Medicine from 1949 to 1956, at SUNY Brooklyn from 1956 to 1989, and at the University of Miami from 1989 through the end of his career.

In 1978, Furchgott discovered a substance in endothelial cells that relaxes blood vessels, calling it endothelium-derived relaxing factor (EDRF).[2] By 1986, he had worked out EDRF's nature and mechanism of action, and determined that EDRF was in fact nitric oxide (NO), an important compound in many aspects of cardiovascular physiology. This research is important in explaining a wide variety of neuronal, cardiovascular, and general physiologic processes of central importance in human health and disease.[3]

In addition to receiving the Nobel Prize in Physiology or Medicine for the discovery of nitric oxide as a new cellular signal in 1998 with Louis Ignarro and Ferid Murad,[4][5] [6] [7][8] [9] [10] Furchgott's discovery that Nitric Oxide causes blood vessels to dilate, provided a long-sought explanation for the therapeutic effects of Nitroglycerin used to treat Angina pectoris and was later instrumental in the development of the erectile dysfunction treatment drug Viagra.[11]

In 1991, Furchgott received a Gairdner Foundation International Award for his groundbreaking discoveries.[citation needed] He also received the Albert Lasker Award for Basic Medical Research in 1996[12] and the Golden Plate Award of the American Academy of Achievement in 1999 with Ferid Murad.[13][14]

Personal life edit

Furchgott was Jewish[15] and lived most of his married and career life in Woodmere, New York on Long Island. He was married to Lenore Mandelbaum (February 1915 – April 1983)[16] from 1941 until her death at age 68. They had three daughters: Jane, Terry, and Susan. His daughter, Susan, was an artist in the San Francisco counter-culture and co-founder of the Kerista Commune.

Furchgott spent his later years with Margaret Gallagher Roth, who died March 14, 2006.[17] He served as a professor emeritus at the State University of New York Downstate Medical Center. In 2008, he moved to Seattle's Ravenna neighborhood.

Death edit

Furchgott died on May 19, 2009, in Seattle. He is survived by his three daughters, four grandchildren, and three great-grandchildren.[18]

See also edit

Further reading edit

  • Anon. (2009) "Obituary: Robert Furchgott," The Telegraph (online), May 26, 2009, see,[19] accessed 11 August 2015.
  • Raju, T N (2000), "The Nobel chronicles. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).", Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346, doi:10.1016/s0140-6736(05)73635-7, PMID 11071225, S2CID 53221905
  • Rabelink, A J (1998), "Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule", Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30, PMID 10065255
  • Laufs, U; Erdmann, E (1998), "Nitric oxide as a signal molecule in the cardiovascular system. Nobel Prize for Medicine in 1998", Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5, doi:10.1055/s-0029-1237297, PMID 9893684, S2CID 68505199
  • Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Nobel Prize 1998 in physiology or medicine. Nitrogen oxide as a signal molecule in the cardiovascular system", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8, PMID 9889673
  • Nielsen, T T; Sørensen, K E (1998), "Discovery of "endogenous nitroglycerin", NO, as cellular signal molecule", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567, PMID 9889670
  • Mitka, M (1998), "1998 Nobel Prize winners are announced: three discoverers of nitric oxide activity", JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648, doi:10.1001/jama.280.19.1648, PMID 9831980
  • Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine. Nitric oxide as a signal molecule in the cardiovascular system", Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8, PMID 9821753

References edit

  1. ^ Robert F. Furchgott at Encyclopedia Britannica
  2. ^ Furchgott, Robert F.; Zawadzki, John V. (November 1980). "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine". Nature. 288 (5789): 373–376. Bibcode:1980Natur.288..373F. doi:10.1038/288373a0. ISSN 0028-0836. PMID 6253831. S2CID 4303932.
  3. ^ "Summary: The Nobel Prize in Physiology or Medicine 1998". NobelPrize.org. Nobel Media AB 2020. Retrieved 4 January 2020.
  4. ^ Raju, T N (2000), "The Nobel chronicles. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).", Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346, doi:10.1016/s0140-6736(05)73635-7, PMID 11071225, S2CID 53221905
  5. ^ Rabelink, A J (1998), "Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule", Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30, PMID 10065255
  6. ^ Laufs, U; Erdmann, E (1998), "Nitric oxide as a signal molecule in the cardiovascular system. Nobel Prize for Medicine in 1998", Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5, doi:10.1055/s-0029-1237297, PMID 9893684, S2CID 68505199
  7. ^ Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Nobel Prize 1998 in physiology or medicine. Nitrogen oxide as a signal molecule in the cardiovascular system", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8, PMID 9889673
  8. ^ Nielsen, T T; Sørensen, K E (1998), "Discovery of "endogenous nitroglycerin", NO, as cellular signal molecule", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567, PMID 9889670
  9. ^ Mitka, M (1998), "1998 Nobel Prize winners are announced: three discoverers of nitric oxide activity", JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648, doi:10.1001/jama.280.19.1648, PMID 9831980
  10. ^ Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine. Nitric oxide as a signal molecule in the cardiovascular system", Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8, PMID 9821753
  11. ^ BBC News vom 23. Mai 2009: US „Viagra scientist“ dies at 92.
  12. ^ Furchgott, R.F. (1996), "The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide", JAMA, vol. 276, no. 14 (published Oct 9, 1996), pp. 1186–8, doi:10.1001/jama.276.14.1186, PMID 8827976
  13. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  14. ^ Robert F. Furchgott at Encyclopedia Britannica
  15. ^ "Seymour "Sy" Brody's". Fau.edu. Retrieved 2015-08-11.
  16. ^ "RootsWeb: Database Index". Ssdi.rootsweb.ancestry.com. Retrieved 2015-08-11.
  17. ^ "Paid Notice - Deaths ROTH, MARGARET - Paid Death Notice - NYTimes.com". New York Times. 2006-03-17. Retrieved 2015-08-11.
  18. ^ "SUNY Downstate Medical Center". Downstate.edu. Retrieved 2015-08-11.
  19. ^ "Robert Furchgott". Telegraph. 2009-05-26. Retrieved 2015-08-11.

External links edit

  • The Robert F. Furchgott Society 2012-05-04 at the Wayback Machine
  • Robert F. Furchgott on Nobelprize.org  
  • His laboratory's webpage 2012-06-23 at the Wayback Machine

January 01, 1970
robert, furchgott, robert, francis, furchgott, june, 1916, 2009, nobel, prize, winning, american, biochemist, contributed, discovery, nitric, oxide, transient, cellular, signal, mammalian, systems, bornrobert, francis, furchgottjune, 1916, 1916, charleston, so. Robert Francis Furchgott June 4 1916 May 19 2009 was a Nobel Prize winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems Robert F FurchgottBornRobert Francis FurchgottJune 4 1916 1916 06 04 Charleston South Carolina U S DiedMay 19 2009 2009 05 19 aged 92 Seattle Washington U S Alma materUniversity of North Carolina at Chapel HillNorthwestern UniversitySpouse s Lenore Mandelbaum 1941 1983 her death 3 children Margaret Gallagher Roth 2006 her death AwardsNobel Prize in Physiology or Medicine in 1998Scientific careerFieldsBiochemistryInstitutionsCornell University 1940 1949 Washington University in St Louis 1949 1956 SUNY Downstate Medical Center 1956 2009 University of Miami 1989 2009 Signature Contents 1 Early life and education 2 Career 3 Personal life 4 Death 5 See also 6 Further reading 7 References 8 External linksEarly life and education editFurchgott was born in Charleston South Carolina to Arthur Furchgott December 1884 January 1971 a department store owner and Pena Sorentrue Furchgott He graduated with from the University of North Carolina at Chapel Hill in 1937 with a degree in chemistry and went on to earn a Ph D in biochemistry at Northwestern University in 1940 1 Career edit nbsp Furchgott and other 1998 Nobel Prize winners with former U S President Bill Clinton November 1998 Furchgott was faculty member and professor of pharmacology at Cornell University Medical College from 1940 to 1949 at Washington University School of Medicine from 1949 to 1956 at SUNY Brooklyn from 1956 to 1989 and at the University of Miami from 1989 through the end of his career In 1978 Furchgott discovered a substance in endothelial cells that relaxes blood vessels calling it endothelium derived relaxing factor EDRF 2 By 1986 he had worked out EDRF s nature and mechanism of action and determined that EDRF was in fact nitric oxide NO an important compound in many aspects of cardiovascular physiology This research is important in explaining a wide variety of neuronal cardiovascular and general physiologic processes of central importance in human health and disease 3 In addition to receiving the Nobel Prize in Physiology or Medicine for the discovery of nitric oxide as a new cellular signal in 1998 with Louis Ignarro and Ferid Murad 4 5 6 7 8 9 10 Furchgott s discovery that Nitric Oxide causes blood vessels to dilate provided a long sought explanation for the therapeutic effects of Nitroglycerin used to treat Angina pectoris and was later instrumental in the development of the erectile dysfunction treatment drug Viagra 11 In 1991 Furchgott received a Gairdner Foundation International Award for his groundbreaking discoveries citation needed He also received the Albert Lasker Award for Basic Medical Research in 1996 12 and the Golden Plate Award of the American Academy of Achievement in 1999 with Ferid Murad 13 14 Personal life editFurchgott was Jewish 15 and lived most of his married and career life in Woodmere New York on Long Island He was married to Lenore Mandelbaum February 1915 April 1983 16 from 1941 until her death at age 68 They had three daughters Jane Terry and Susan His daughter Susan was an artist in the San Francisco counter culture and co founder of the Kerista Commune Furchgott spent his later years with Margaret Gallagher Roth who died March 14 2006 17 He served as a professor emeritus at the State University of New York Downstate Medical Center In 2008 he moved to Seattle s Ravenna neighborhood Death editFurchgott died on May 19 2009 in Seattle He is survived by his three daughters four grandchildren and three great grandchildren 18 See also editList of Jewish Nobel laureatesFurther reading editAnon 2009 Obituary Robert Furchgott The Telegraph online May 26 2009 see 19 accessed 11 August 2015 Raju T N 2000 The Nobel chronicles 1998 Robert Francis Furchgott b 1911 Louis J Ignarro b 1941 and Ferid Murad b 1936 Lancet vol 356 no 9226 published Jul 22 2000 p 346 doi 10 1016 s0140 6736 05 73635 7 PMID 11071225 S2CID 53221905 Rabelink A J 1998 Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule Nederlands Tijdschrift voor Geneeskunde vol 142 no 52 published Dec 26 1998 pp 2828 30 PMID 10065255 Laufs U Erdmann E 1998 Nitric oxide as a signal molecule in the cardiovascular system Nobel Prize for Medicine in 1998 Dtsch Med Wochenschr vol 123 no 51 52 published Dec 18 1998 pp 1562 5 doi 10 1055 s 0029 1237297 PMID 9893684 S2CID 68505199 Hansson G K Jornvall H Lindahl S G 1998 The Nobel Prize 1998 in physiology or medicine Nitrogen oxide as a signal molecule in the cardiovascular system Ugeskrift for Laeger vol 160 no 52 published Dec 21 1998 pp 7571 8 PMID 9889673 Nielsen T T Sorensen K E 1998 Discovery of endogenous nitroglycerin NO as cellular signal molecule Ugeskrift for Laeger vol 160 no 52 published Dec 21 1998 p 7567 PMID 9889670 Mitka M 1998 1998 Nobel Prize winners are announced three discoverers of nitric oxide activity JAMA vol 280 no 19 published Nov 18 1998 p 1648 doi 10 1001 jama 280 19 1648 PMID 9831980 Hansson G K Jornvall H Lindahl S G 1998 1998 Nobel Prize in physiology or medicine Nitric oxide as a signal molecule in the cardiovascular system Lakartidningen vol 95 no 43 published Oct 21 1998 pp 4703 8 PMID 9821753References edit Robert F Furchgott at Encyclopedia Britannica Furchgott Robert F Zawadzki John V November 1980 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 5789 373 376 Bibcode 1980Natur 288 373F doi 10 1038 288373a0 ISSN 0028 0836 PMID 6253831 S2CID 4303932 Summary The Nobel Prize in Physiology or Medicine 1998 NobelPrize org Nobel Media AB 2020 Retrieved 4 January 2020 Raju T N 2000 The Nobel chronicles 1998 Robert Francis Furchgott b 1911 Louis J Ignarro b 1941 and Ferid Murad b 1936 Lancet vol 356 no 9226 published Jul 22 2000 p 346 doi 10 1016 s0140 6736 05 73635 7 PMID 11071225 S2CID 53221905 Rabelink A J 1998 Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule Nederlands Tijdschrift voor Geneeskunde vol 142 no 52 published Dec 26 1998 pp 2828 30 PMID 10065255 Laufs U Erdmann E 1998 Nitric oxide as a signal molecule in the cardiovascular system Nobel Prize for Medicine in 1998 Dtsch Med Wochenschr vol 123 no 51 52 published Dec 18 1998 pp 1562 5 doi 10 1055 s 0029 1237297 PMID 9893684 S2CID 68505199 Hansson G K Jornvall H Lindahl S G 1998 The Nobel Prize 1998 in physiology or medicine Nitrogen oxide as a signal molecule in the cardiovascular system Ugeskrift for Laeger vol 160 no 52 published Dec 21 1998 pp 7571 8 PMID 9889673 Nielsen T T Sorensen K E 1998 Discovery of endogenous nitroglycerin NO as cellular signal molecule Ugeskrift for Laeger vol 160 no 52 published Dec 21 1998 p 7567 PMID 9889670 Mitka M 1998 1998 Nobel Prize winners are announced three discoverers of nitric oxide activity JAMA vol 280 no 19 published Nov 18 1998 p 1648 doi 10 1001 jama 280 19 1648 PMID 9831980 Hansson G K Jornvall H Lindahl S G 1998 1998 Nobel Prize in physiology or medicine Nitric oxide as a signal molecule in the cardiovascular system Lakartidningen vol 95 no 43 published Oct 21 1998 pp 4703 8 PMID 9821753 BBC News vom 23 Mai 2009 US Viagra scientist dies at 92 Furchgott R F 1996 The 1996 Albert Lasker Medical Research Awards The discovery of endothelium derived relaxing factor and its importance in the identification of nitric oxide JAMA vol 276 no 14 published Oct 9 1996 pp 1186 8 doi 10 1001 jama 276 14 1186 PMID 8827976 Golden Plate Awardees of the American Academy of Achievement www achievement org American Academy of Achievement Robert F Furchgott at Encyclopedia Britannica Seymour Sy Brody s Fau edu Retrieved 2015 08 11 RootsWeb Database Index Ssdi rootsweb ancestry com Retrieved 2015 08 11 Paid Notice Deaths ROTH MARGARET Paid Death Notice NYTimes com New York Times 2006 03 17 Retrieved 2015 08 11 SUNY Downstate Medical Center Downstate edu Retrieved 2015 08 11 Robert Furchgott Telegraph 2009 05 26 Retrieved 2015 08 11 External links editThe Robert F Furchgott Society Archived 2012 05 04 at the Wayback Machine Robert F Furchgott on Nobelprize org nbsp His laboratory s webpage Archived 2012 06 23 at the Wayback Machine Retrieved from https en wikipedia org w index php title Robert F Furchgott amp oldid 1175978342, wikipedia, wiki, book, books, library,

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