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Richard Sykes (microbiologist)

January 01, 1970

Sir Richard Brook Sykes FRS FMedSci HonFREng (born 7 August 1942) is a British microbiologist, the chair of the Royal Institution, the UK Stem Cell Foundation, and the trustees at King Edward VII's Hospital, and chancellor of Brunel University. As of June 2021, he is chair of the UK's Vaccine Taskforce, where he is responsible for overseeing the delivery of the COVID-19 vaccination programme, including preparations for booster programmes and encouraging vaccine innovation in the UK.

Sir
Richard Sykes
FRS FMedSci HonFREng
Born
Richard Brook Sykes

(1942-08-07) 7 August 1942 (age 81)
Huddersfield, West Yorkshire, England
Education
Alma mater
Known for
Awards
Scientific career
Fields
Institutions
Chair of the Vaccine Taskforce
Assumed office
2021

In 1972, after gaining a first class bachelor's degree and a doctorate, both in microbiology, Sykes was appointed head of the Antibiotic Resistance Unit at Glaxo, where he helped develop the antibiotic ceftazidime. Subsequently, he was recruited by the Squibb Institute, in the United States, where he then developed aztreonam, the first clinically effective monobactam, a term he coined in 1981 to describe a new group of monocyclic β-lactams produced by bacteria. He oversaw the merger of Glaxo with Wellcome, to form Glaxo-Wellcome in 1995 and became its chair two years later. He then oversaw the Glaxo Wellcome and SmithKline Beecham merger and held its chair until 2001.

His other appointments have included being rector of Imperial College from 2001 to 2008, chairman of NHS London from December 2008 to July 2010, vice-chairman of Lonza Group until 2013, and chairman of Imperial College Healthcare from 2012 to 2018.

Early life and education edit

Richard Sykes was born in the outskirts of Huddersfield, in West Yorkshire, on 7 August 1942[1] to Eric Sykes and his wife Muriel Mary Sykes.[2][3] He attended Royds Hall Grammar school.[4] Prior to his A-levels and completing school, he took up a job as a technician in a pathology laboratory.[5] After leaving secondary school he attended Paddington Technical College and Chelsea College, and gained a place at Queen Elizabeth College where he was awarded a first class BSc degree in microbiology.[2] He received his doctorate in 1972 with a thesis on β-lactamases of Pseudomonas aeruginosa, from the University of Bristol, where he worked with Mark Richmond.[2][6] In 1973, together, they reported the first β-lactamase classification scheme.[7]

Glaxo and Squibb edit

 
GlaxoSmithKline Headquarters

In 1972, Sykes was appointed head of the Antibiotic Resistance Unit at Glaxo.[2][8] There, he helped develop the antibiotic ceftazidime.[9] In 1977 he left Glaxo and was recruited to the United States by the Squibb Institute for Medical Research, where he worked under George B. Mackaness, the Australian immunologist who played an important part in getting the first ACE inhibitor, captopril, licensed.[2][10] In 1979 Squibb appointed Sykes to lead research into monocyclic β-lactam antibiotics.[2][9] There, he isolated product SQ26.180 from Chromobacterium violaceum, a bacteria discovered at Pine Barrens.[11] By modifying the amide side chain and including a ceftazidime side chain, he produced aztreonam, the first monocyclic β-lactam antibiotic.[12][13] In 1981 he coined this new group of antibiotics "monobactam".[9][12] Its potential as a usefulness was published the following year.[14] It could treat gram-negative infections such as gonorrhoea and became the first monobactam to be licensed for clinical use.[9][12]

From 1983 to 1986 he was vice-president of infectious and metabolic diseases at Squibb.[2] He returned to Glaxo in 1987 and succeeded David Jack, almost 30 years after Glaxo acquired Allen & Hanburys.[15] The Harvard Business Review noted that at Glaxo, when a group of antibiotics failed in the last stages of clinical trial, Sykes praised the teams that had worked on them and encouraged them to move on.[8] In 1993 he received his DSc.[2]

In 1994, during his time at Glaxo, he was part of the group that founded the Jenner Institute for research into vaccines.[16][17][18] In 1995 he oversaw the merger of Glaxo with Wellcome, to form Glaxo-Wellcome.[15][19] In 1997, he became chair of Glaxo-Wellcome.[20] In 2000 he oversaw the Glaxo Wellcome and SmithKline Beecham merger and held its chair until 2001.[20][21][22] The merger resulted in the marketing of several new drugs.[21] According to Sykes at the time, "the industry would be transformed by understanding the human genome".[21]

Royal Institution and others edit

Sykes was elected a Fellow of the Royal Society (FRS) in 1997.[23][24] In 1994 he became a trustee of the Natural History Museum, London,[2] and in 1997 he was appointed senior independent director of Rio Tinto plc, a position he held until 2008.[25]

He was a member of the National Committee of Inquiry into Higher Education that published an influential report in 1997.[clarification needed][26]

Later career edit

Imperial edit

In January 2001, he was appointed rector of Imperial College London and completed his tenure in 2008.[27][28][29] At Imperial, he was involved in several controversial debates including on issues such as increasing tuition fees, which he favoured.[30] He criticised secondary schools for the quality of the science taught there, and opposed teaching grants being awarded on a per capita basis.[28][31] In 2002 he proposed to merge Imperial College with University College London.[32][33] The strength of opposition meant that it did not go through.[28] He supported the lifting of the £3,000 cap on tuition fees and instead allowing the universities to set their own fees.[32][34]

UK Stem Cell Foundation edit

Sykes chairs the UK Stem Cell Foundation.[25] It was established in 2005.[35][36][37]

Other roles edit

From 2003 to 2005 he was trustee of the Royal Botanic Gardens, Kew.[2] From 2007 to 2011 he was senior independent director and non-executive deputy chairman of Eurasian Natural Resources Corporation.[25][38] In September 2008, he was appointed chair of NHS London, but resigned in May 2010 over the decision of the Cameron Ministry to halt former health minister Ara Darzi's planned reorganisation of health care in London.[39][40]

Between 2010 and 2012 he was on the advisory board of the Virgin Group.[25] Until 2013, he was vice-chair at the Swiss life sciences company Lonza AG.[25][41] He was appointed chairman of the Royal Institution in 2010 and Imperial College Healthcare in 2012.[2] He was appointed Chancellor of Brunel University in 2013.[42] In 2020, Sykes stepped down as chairman of the NetScientific Group after serving it for nine years.[43]

Vaccine Taskforce edit

In 2020 he led an independent review of the workings of the Vaccine Taskforce.[44][45] On 14 June 2021, Sykes was appointed chair of the Vaccine Taskforce, where he will be responsible for overseeing the delivery of the UK's COVID-19 vaccination programme, including preparations for booster programmes and encouraging vaccine innovation in the UK.[44]

Other activities edit

Sykes was chairman of the advisory panel of the think-tank Reform.[46] He is a member of the Advisory Council for the Campaign for Science and Engineering.[47] He is chair of the Trustees at King Edward VII's Hospital.[48]

Awards and honours edit

Sykes was knighted in the 1994 New Year Honours.[2][49]

He holds honorary degrees from several universities including Birmingham, Brunel, Cranfield, Edinburgh, Hertfordshire, Huddersfield, Hull, Leeds, Leicester, Madrid, Newcastle, Nottingham, Sheffield Hallam, Sheffield, Strathclyde, Surrey, Warwick and Westminster. Sykes was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 1998.[50]

In 2009 he received the British Society for Antimicrobial Chemotherapy's Garrod Medal and delivered its accompanying lecture.[51] It was titled "The evolution of antimicrobial resistance: a Darwinian perspective" and was published in the Journal of Antimicrobial Chemotherapy in 2010.[52]

Selected publications edit

Articles edit

  • Richmond, M.H.; Sykes, R.B. (1973). "The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role". Advances in Microbial Physiology Volume 9. Advances in Microbial Physiology. Vol. 9. pp. 31–88. doi:10.1016/S0065-2911(08)60376-8. ISBN 978-0-12-027709-4. PMID 4581138. (Co-author)
  • Sykes, R. B.; Cimarusti, C. M.; Bonner, D. P.; Bush, K.; Floyd, D. M.; Georgopapadakou, N. H.; Koster, W. H.; Liu, W. C.; Parker, W. L.; Principe, P. A.; Rathnum, M. L.; Slusarchyk, W. A.; Trejo, W. H.; Wells, J. S. (1981). "Monocyclic β-lactam antibiotics produced by bacteria". Nature. 291 (5815): 489–91. Bibcode:1981Natur.291..489S. doi:10.1038/291489a0. PMID 7015152. S2CID 4303108. (Co-author)
  • Bush, K.; Freudenberger, J. S.; Sykes, R. B. (1982). "Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria". Antimicrobial Agents and Chemotherapy. 22 (3): 414–20. doi:10.1128/AAC.22.3.414. PMC 183759. PMID 6982680. (Co-author)
  • Sykes, R. B.; Bonner, D. P.; Bush, K.; Georgopapadakou, N. H. (January 1982). "Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria". Antimicrobial Agents and Chemotherapy. 21 (1): 85–92. doi:10.1128/AAC.21.1.85. ISSN 0066-4804. PMC 181833. PMID 6979307. (Co-author)
  • Sykes, R. (2001). "Penicillin: from discovery to product" (PDF). Bulletin of the World Health Organization. 79 (8): 778–779. ISSN 0042-9686. PMC 2566502. PMID 11545336. S2CID 33582904.
  • Sykes, R. (1999). "The 1998 Radcliffe Lecture. Medicines, Morals and Money: the high ground and the bottom line". Business Ethics: A European Review. 8 (2): 79–87. doi:10.1111/1467-8608.00132. ISSN 1467-8608. PMID 11657843.
  • Sykes, R. (1 September 2010). "The 2009 Garrod Lecture: The evolution of antimicrobial resistance: a Darwinian perspective". Journal of Antimicrobial Chemotherapy. 65 (9): 1842–1852. doi:10.1093/jac/dkq217. PMID 20573657.

Books edit

  • New Medicines: The Practice of Medicine and Public Policy. The Nuffield Trust. 2000. ISBN 978-0-1170-2676-6.

Reports edit

  • UK Vaccine Taskforce 2020 Achievements and Future Strategy (PDF). Gov.UK. December 2020.

References edit

  1. ^ Connon, Heather (20 June 2004). "Imperial boss measures up money men". The Guardian. Retrieved 7 August 2023.
  2. ^ a b c d e f g h i j k l Who's Who 2018 (170th ed.). London: Bloomsbury Publishing. 2018. p. 2380. ISBN 978-1-472-93501-4.
  3. ^ Wong, John (6 July 2015) Citation by professor John Wong. National University of Singapore. Honorary degree of science recipient
  4. ^ Fletcher, Winston (2003). "1. Sir Richard Sykes FRS". Beating the 24/7: How Business Leaders Achieve a Successful Work/Life Balance. Chichester: John Wiley & Sons. pp. 31–40. ISBN 0-470-84762-X.
  5. ^ Lawrence, Rebecca N. (15 June 2002). "Sir Richard Sykes contemplates the future of the pharma industry. Interview by Rebecca N Lawrence". Drug Discovery Today. 7 (12): 645–648. doi:10.1016/s1359-6446(02)02305-x. ISSN 1359-6446. PMID 12110238.
  6. ^ Sykes, Richard (September 2010). "The 2009 Garrod lecture: the evolution of antimicrobial resistance: a Darwinian perspective". The Journal of Antimicrobial Chemotherapy. 65 (9): 1842–1852. doi:10.1093/jac/dkq217. ISSN 1460-2091. PMID 20573657.
  7. ^ Cooksey, Robert C. (1998). "13. Mechanisms of resistance to antibacterial agents". In Bittar, Edward (ed.). Microbiology. Greenwich, Connecticut: Elsevier. p. 207. ISBN 1-55938-814-5.
  8. ^ a b Goffee, Rob; Jones, Gareth (March 2007). "Leading clever people". Harvard Business Review. 85 (3): 72–79, 142. ISSN 0017-8012. PMID 17348171.
  9. ^ a b c d Greenwood, David (2008). "4. Wonder drugs". Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. Oxford: Oxford University Press. p. 134. ISBN 978-0-19-953484-5.
  10. ^ Carter, P. B. (2014). "George Bellamy Mackaness. 20 August 1922 — 4 March 2007". Biographical Memoirs of Fellows of the Royal Society. 60: 294. doi:10.1098/RSBM.2014.0017. S2CID 71237348.
  11. ^ Sacharow, Fredda (13 June 1982). . The New York Times. Archived from the original on 3 December 2021. Retrieved 2 December 2021.
  12. ^ a b c Stromgaard, Kristian; Krogsgaard-Larsen, Povl; Madsen, Ulf (2009). Textbook of Drug Design and Discovery. CRC Press. p. 429. ISBN 978-1-4200-6322-6.
  13. ^ Sneader, Walter (2005). "23. Antibiotic analogues". Drug Discovery: A History. Chichester, West Sussex: Wiley. p. 337. ISBN 978-0-471-89979-2.
  14. ^ Fisher, Jed (2012). "2. B-Lactams resistant to hydrolysis by the b-lactamases". In Bryan, L. (ed.). Antimicrobial Drug Resistance. Orlando: Academic press. p. 51. ISBN 978-0-12-138120-2.
  15. ^ a b Ravenscraft, David J.; Long, William F. (2007). "Paths to creating value in pharmaceutical mergers". In Kaplan, Steven N. (ed.). Mergers and Productivity. University of Chicago Press. pp. 306–310. ISBN 978-0-226-42431-6.
  16. ^ MRC Annual Report. Medical Research Council. 1994. p. 26.
  17. ^ "The Vaccine Taskforce: objectives and membership of steering group" (PDF). GOV.UK. Retrieved 30 November 2021.
  18. ^ Dickson, David (1 December 1998). "Research trio to develop new vaccines". Nature Medicine. 4 (12): 1349. doi:10.1038/3927. ISSN 1546-170X. PMID 9846561. S2CID 33610131.
  19. ^ Brier, Jennifer (2009). Infectious Ideas: U.S. Political Responses to the AIDS Crisis. University of North Carolina Press. p. 193. ISBN 978-0-8078-3314-8.
  20. ^ a b Gay, Hannah; Scientific (Firm), World (2013). The Silwood Circle: A History of Ecology and the Making of Scientific Careers in Late Twentieth-Century Britain. World Scientific. p. 183. ISBN 978-1-84816-991-3.
  21. ^ a b c Rugman, Alan M. (2005). The Regional Multinationals: MNEs and 'Global' Strategic Management. Cambridge: Cambridge University Press. p. 123. ISBN 0-521-84265-4.
  22. ^ Fuller, Steve (2009). "1. Introduction: the place of intellectual life". The Sociology of Intellectual Life: The Career of the Mind in and Around Academy. Los Angeles: SAGE. p. 15. ISBN 978-1-4129-2838-0.
  23. ^ "Richard Sykes | Royal Society". royalsociety.org. Retrieved 30 November 2021.
  24. ^ "Library and Archive Catalogue EC/1997/33 Sir Richard Brook". London: The Royal Society.
  25. ^ a b c d e "Sir Richard Sykes (1942–)". www.rigb.org.
  26. ^ . Education England. Archived from the original on 11 February 2015. Retrieved 10 February 2015.
  27. ^ Heaman, Elsbeth (2003). "14. Science and strategy; the merger with Imperial College". St Mary's: The History of a London Teaching Hospital. Montreal: Liverpool University Press. p. 417. ISBN 0-85323-968-1.
  28. ^ a b c "Richard Sykes" (PDF). Imperial College London. London: Imperial College. Retrieved 9 November 2021.
  29. ^ Evatt, M. A. C.; Brodhurst, E. K. (2002). Sharing Experience in Engineering Design (SEED 2002). John Wiley & Sons. ISBN 978-1-86058-397-1.
  30. ^ "A Rector to remember". Imperial Matters: Alumni Magazine (32): 10–13. 2008.
  31. ^ Gay, Hannah (2007). "15. The expanding college, 1985-2001...Part 1: Governance and the medical school mergers". History Of Imperial College London, 1907–2007, The: Higher Education And Research In Science, Technology And Medicine. London: Imperial College Press. p. 604. ISBN 978-1-86094-708-7.
  32. ^ a b Harte, Negley; North, John; Brewis, Georgina (21 May 2018). The World of UCL. UCL Press. ISBN 9781787352933.
  33. ^ "Opposition ends Imperial and UCL merger dream". The Guardian. 18 November 2002. Retrieved 13 April 2021.
  34. ^ The future sustainability of the higher education sector: international aspects, eighth report of session 2006–07, Vol. 2: Oral and written evidence. The Stationery Office. 2007. p. 43. ISBN 978-0-215-03600-1.
  35. ^ Devaney, Sarah (2013). Stem Cell Research and the Collaborative Regulation of Innovation. Abingdon, Oxford: Routledge. p. 39. ISBN 978-0-415-52130-7.
  36. ^ "House of Commons Hansard Debates for 7 Mar 2005 (pt 29)". publications.parliament.uk. Parliament.co.uk. Retrieved 30 November 2021.
  37. ^ Furcht, Leo; Hoffman, William (2011). The Stem Cell Dilemma: The Scientific Breakthroughs, Ethical Concerns, Political Tensions, and Hope Surrounding Stem Cell Research (in Dutch). Simon and Schuster. p. 230. ISBN 978-1-62872-181-2.
  38. ^ Bawden, Tom (10 June 2011). "Sir Richard Sykes: voted out, but not down". The Guardian. Retrieved 2 December 2021.
  39. ^ Randeep Ramesh (26 May 2010). "NHS London chief Richard Sykes resigns in care review row". The Guardian. Retrieved 27 May 2010.
  40. ^ Wise, Jacqui (5 June 2010). "BMJ News" (PDF). British Medical Journal. 340: 1216–1217.
  41. ^ ENRC Management 28 May 2011 at the Wayback Machine
  42. ^ Sir Richard Sykes appointed Chancellor of Brunel University 14 May 2014 at the Wayback Machine
  43. ^ . NetScientific. 31 March 2020. Archived from the original on 9 November 2021. Retrieved 9 November 2021.
  44. ^ a b . GOV.UK. Archived from the original on 13 September 2021. Retrieved 25 October 2021.
  45. ^ . Medscape. Archived from the original on 16 January 2021. Retrieved 12 November 2021.
  46. ^ "Tax cuts, yes, but first reform public services. Daily Telegraph 3 September 2006".
  47. ^ . Archived from the original on 28 August 2010. Retrieved 11 February 2011.
  48. ^ . King Edward VII's Hospital. Archived from the original on 16 May 2022. Retrieved 25 October 2021.
  49. ^ Sir Richard Sykes DSc – 1994 3 March 2016 at the Wayback Machine
  50. ^ Fellow Sir Richard Sykes FRS FMedSci – website of the Academy of Medical Sciences
  51. ^ "Garrod Lecture & Medal". The British Society for Antimicrobial Chemotherapy. 2021. from the original on 2 November 2021. Retrieved 2 November 2021.
  52. ^ Sykes, R. (1 September 2010). "The 2009 Garrod Lecture: The evolution of antimicrobial resistance: a Darwinian perspective". Journal of Antimicrobial Chemotherapy. 65 (9): 1842–1852. doi:10.1093/jac/dkq217. PMID 20573657.

External links edit

  • Richard Sykes's publications indexed by the Scopus bibliographic database. (subscription required)
Academic offices
Preceded by Rector of Imperial College London
2000–2008 		Succeeded by
Preceded by Chancellor of Brunel University
2013–present 		Succeeded by
Incumbent

January 01, 1970
richard, sykes, microbiologist, richard, brook, sykes, fmedsci, honfreng, born, august, 1942, british, microbiologist, chair, royal, institution, stem, cell, foundation, trustees, king, edward, hospital, chancellor, brunel, university, june, 2021, chair, vacci. Sir Richard Brook Sykes FRS FMedSci HonFREng born 7 August 1942 is a British microbiologist the chair of the Royal Institution the UK Stem Cell Foundation and the trustees at King Edward VII s Hospital and chancellor of Brunel University As of June 2021 he is chair of the UK s Vaccine Taskforce where he is responsible for overseeing the delivery of the COVID 19 vaccination programme including preparations for booster programmes and encouraging vaccine innovation in the UK SirRichard SykesFRS FMedSci HonFREngBornRichard Brook Sykes 1942 08 07 7 August 1942 age 81 Huddersfield West Yorkshire EnglandEducationRoyds Hall Grammar school Paddington Technical College Chelsea College Queen Elizabeth College University of BristolAlma materQueen Elizabeth College BSc University of Bristol PhD Brunel University DSc Known forMonobactam 1981 Formation of Glaxo Wellcome 1995 Formation of GlaxoSmithKline 2000 Rector of Imperial College 2001 2008 Chair of Royal Institution 2010 AwardsKnight Bachelor 1994 Garrod Lecture and Medal 2009 Scientific careerFieldsMicrobiology AntibioticsInstitutionsImperial College London Imperial College Healthcare GlaxoSmithKline Squibb Institute for Medical Research Natural History Museum London Royal Botanic Gardens Kew NHS London Brunel University Eurasian Natural Resources Corporation Reform think tankChair of the Vaccine TaskforceIncumbentAssumed office 2021 In 1972 after gaining a first class bachelor s degree and a doctorate both in microbiology Sykes was appointed head of the Antibiotic Resistance Unit at Glaxo where he helped develop the antibiotic ceftazidime Subsequently he was recruited by the Squibb Institute in the United States where he then developed aztreonam the first clinically effective monobactam a term he coined in 1981 to describe a new group of monocyclic b lactams produced by bacteria He oversaw the merger of Glaxo with Wellcome to form Glaxo Wellcome in 1995 and became its chair two years later He then oversaw the Glaxo Wellcome and SmithKline Beecham merger and held its chair until 2001 His other appointments have included being rector of Imperial College from 2001 to 2008 chairman of NHS London from December 2008 to July 2010 vice chairman of Lonza Group until 2013 and chairman of Imperial College Healthcare from 2012 to 2018 Contents 1 Early life and education 2 Glaxo and Squibb 3 Royal Institution and others 4 Later career 4 1 Imperial 4 2 UK Stem Cell Foundation 4 3 Other roles 4 4 Vaccine Taskforce 5 Other activities 6 Awards and honours 7 Selected publications 7 1 Articles 7 2 Books 7 3 Reports 8 References 9 External linksEarly life and education editRichard Sykes was born in the outskirts of Huddersfield in West Yorkshire on 7 August 1942 1 to Eric Sykes and his wife Muriel Mary Sykes 2 3 He attended Royds Hall Grammar school 4 Prior to his A levels and completing school he took up a job as a technician in a pathology laboratory 5 After leaving secondary school he attended Paddington Technical College and Chelsea College and gained a place at Queen Elizabeth College where he was awarded a first class BSc degree in microbiology 2 He received his doctorate in 1972 with a thesis on b lactamases of Pseudomonas aeruginosa from the University of Bristol where he worked with Mark Richmond 2 6 In 1973 together they reported the first b lactamase classification scheme 7 Glaxo and Squibb edit nbsp GlaxoSmithKline Headquarters In 1972 Sykes was appointed head of the Antibiotic Resistance Unit at Glaxo 2 8 There he helped develop the antibiotic ceftazidime 9 In 1977 he left Glaxo and was recruited to the United States by the Squibb Institute for Medical Research where he worked under George B Mackaness the Australian immunologist who played an important part in getting the first ACE inhibitor captopril licensed 2 10 In 1979 Squibb appointed Sykes to lead research into monocyclic b lactam antibiotics 2 9 There he isolated product SQ26 180 from Chromobacterium violaceum a bacteria discovered at Pine Barrens 11 By modifying the amide side chain and including a ceftazidime side chain he produced aztreonam the first monocyclic b lactam antibiotic 12 13 In 1981 he coined this new group of antibiotics monobactam 9 12 Its potential as a usefulness was published the following year 14 It could treat gram negative infections such as gonorrhoea and became the first monobactam to be licensed for clinical use 9 12 From 1983 to 1986 he was vice president of infectious and metabolic diseases at Squibb 2 He returned to Glaxo in 1987 and succeeded David Jack almost 30 years after Glaxo acquired Allen amp Hanburys 15 The Harvard Business Review noted that at Glaxo when a group of antibiotics failed in the last stages of clinical trial Sykes praised the teams that had worked on them and encouraged them to move on 8 In 1993 he received his DSc 2 In 1994 during his time at Glaxo he was part of the group that founded the Jenner Institute for research into vaccines 16 17 18 In 1995 he oversaw the merger of Glaxo with Wellcome to form Glaxo Wellcome 15 19 In 1997 he became chair of Glaxo Wellcome 20 In 2000 he oversaw the Glaxo Wellcome and SmithKline Beecham merger and held its chair until 2001 20 21 22 The merger resulted in the marketing of several new drugs 21 According to Sykes at the time the industry would be transformed by understanding the human genome 21 Royal Institution and others editSykes was elected a Fellow of the Royal Society FRS in 1997 23 24 In 1994 he became a trustee of the Natural History Museum London 2 and in 1997 he was appointed senior independent director of Rio Tinto plc a position he held until 2008 25 He was a member of the National Committee of Inquiry into Higher Education that published an influential report in 1997 clarification needed 26 Later career editImperial edit In January 2001 he was appointed rector of Imperial College London and completed his tenure in 2008 27 28 29 At Imperial he was involved in several controversial debates including on issues such as increasing tuition fees which he favoured 30 He criticised secondary schools for the quality of the science taught there and opposed teaching grants being awarded on a per capita basis 28 31 In 2002 he proposed to merge Imperial College with University College London 32 33 The strength of opposition meant that it did not go through 28 He supported the lifting of the 3 000 cap on tuition fees and instead allowing the universities to set their own fees 32 34 UK Stem Cell Foundation edit Sykes chairs the UK Stem Cell Foundation 25 It was established in 2005 35 36 37 Other roles edit From 2003 to 2005 he was trustee of the Royal Botanic Gardens Kew 2 From 2007 to 2011 he was senior independent director and non executive deputy chairman of Eurasian Natural Resources Corporation 25 38 In September 2008 he was appointed chair of NHS London but resigned in May 2010 over the decision of the Cameron Ministry to halt former health minister Ara Darzi s planned reorganisation of health care in London 39 40 Between 2010 and 2012 he was on the advisory board of the Virgin Group 25 Until 2013 he was vice chair at the Swiss life sciences company Lonza AG 25 41 He was appointed chairman of the Royal Institution in 2010 and Imperial College Healthcare in 2012 2 He was appointed Chancellor of Brunel University in 2013 42 In 2020 Sykes stepped down as chairman of the NetScientific Group after serving it for nine years 43 Vaccine Taskforce edit In 2020 he led an independent review of the workings of the Vaccine Taskforce 44 45 On 14 June 2021 Sykes was appointed chair of the Vaccine Taskforce where he will be responsible for overseeing the delivery of the UK s COVID 19 vaccination programme including preparations for booster programmes and encouraging vaccine innovation in the UK 44 Other activities editSykes was chairman of the advisory panel of the think tank Reform 46 He is a member of the Advisory Council for the Campaign for Science and Engineering 47 He is chair of the Trustees at King Edward VII s Hospital 48 Awards and honours editSykes was knighted in the 1994 New Year Honours 2 49 He holds honorary degrees from several universities including Birmingham Brunel Cranfield Edinburgh Hertfordshire Huddersfield Hull Leeds Leicester Madrid Newcastle Nottingham Sheffield Hallam Sheffield Strathclyde Surrey Warwick and Westminster Sykes was elected a Fellow of the Academy of Medical Sciences FMedSci in 1998 50 In 2009 he received the British Society for Antimicrobial Chemotherapy s Garrod Medal and delivered its accompanying lecture 51 It was titled The evolution of antimicrobial resistance a Darwinian perspective and was published in the Journal of Antimicrobial Chemotherapy in 2010 52 Selected publications editArticles edit Richmond M H Sykes R B 1973 The b Lactamases of Gram Negative Bacteria and their Possible Physiological Role Advances in Microbial Physiology Volume 9 Advances in Microbial Physiology Vol 9 pp 31 88 doi 10 1016 S0065 2911 08 60376 8 ISBN 978 0 12 027709 4 PMID 4581138 Co author Sykes R B Cimarusti C M Bonner D P Bush K Floyd D M Georgopapadakou N H Koster W H Liu W C Parker W L Principe P A Rathnum M L Slusarchyk W A Trejo W H Wells J S 1981 Monocyclic b lactam antibiotics produced by bacteria Nature 291 5815 489 91 Bibcode 1981Natur 291 489S doi 10 1038 291489a0 PMID 7015152 S2CID 4303108 Co author Bush K Freudenberger J S Sykes R B 1982 Interaction of azthreonam and related monobactams with beta lactamases from gram negative bacteria Antimicrobial Agents and Chemotherapy 22 3 414 20 doi 10 1128 AAC 22 3 414 PMC 183759 PMID 6982680 Co author Sykes R B Bonner D P Bush K Georgopapadakou N H January 1982 Azthreonam SQ 26 776 a synthetic monobactam specifically active against aerobic gram negative bacteria Antimicrobial Agents and Chemotherapy 21 1 85 92 doi 10 1128 AAC 21 1 85 ISSN 0066 4804 PMC 181833 PMID 6979307 Co author Sykes R 2001 Penicillin from discovery to product PDF Bulletin of the World Health Organization 79 8 778 779 ISSN 0042 9686 PMC 2566502 PMID 11545336 S2CID 33582904 Sykes R 1999 The 1998 Radcliffe Lecture Medicines Morals and Money the high ground and the bottom line Business Ethics A European Review 8 2 79 87 doi 10 1111 1467 8608 00132 ISSN 1467 8608 PMID 11657843 Sykes R 1 September 2010 The 2009 Garrod Lecture The evolution of antimicrobial resistance a Darwinian perspective Journal of Antimicrobial Chemotherapy 65 9 1842 1852 doi 10 1093 jac dkq217 PMID 20573657 Books edit New Medicines The Practice of Medicine and Public Policy The Nuffield Trust 2000 ISBN 978 0 1170 2676 6 Reports edit UK Vaccine Taskforce 2020 Achievements and Future Strategy PDF Gov UK December 2020 References edit Connon Heather 20 June 2004 Imperial boss measures up money men The Guardian Retrieved 7 August 2023 a b c d e f g h i j k l Who s Who 2018 170th ed London Bloomsbury Publishing 2018 p 2380 ISBN 978 1 472 93501 4 Wong John 6 July 2015 Citation by professor John Wong National University of Singapore Honorary degree of science recipient Fletcher Winston 2003 1 Sir Richard Sykes FRS Beating the 24 7 How Business Leaders Achieve a Successful Work Life Balance Chichester John Wiley amp Sons pp 31 40 ISBN 0 470 84762 X Lawrence Rebecca N 15 June 2002 Sir Richard Sykes contemplates the future of the pharma industry Interview by Rebecca N Lawrence Drug Discovery Today 7 12 645 648 doi 10 1016 s1359 6446 02 02305 x ISSN 1359 6446 PMID 12110238 Sykes Richard September 2010 The 2009 Garrod lecture the evolution of antimicrobial resistance a Darwinian perspective The Journal of Antimicrobial Chemotherapy 65 9 1842 1852 doi 10 1093 jac dkq217 ISSN 1460 2091 PMID 20573657 Cooksey Robert C 1998 13 Mechanisms of resistance to antibacterial agents In Bittar Edward ed Microbiology Greenwich Connecticut Elsevier p 207 ISBN 1 55938 814 5 a b Goffee Rob Jones Gareth March 2007 Leading clever people Harvard Business Review 85 3 72 79 142 ISSN 0017 8012 PMID 17348171 a b c d Greenwood David 2008 4 Wonder drugs Antimicrobial Drugs Chronicle of a Twentieth Century Medical Triumph Oxford Oxford University Press p 134 ISBN 978 0 19 953484 5 Carter P B 2014 George Bellamy Mackaness 20 August 1922 4 March 2007 Biographical Memoirs of Fellows of the Royal Society 60 294 doi 10 1098 RSBM 2014 0017 S2CID 71237348 Sacharow Fredda 13 June 1982 Swamp yields a new antibiotic The New York Times Archived from the original on 3 December 2021 Retrieved 2 December 2021 a b c Stromgaard Kristian Krogsgaard Larsen Povl Madsen Ulf 2009 Textbook of Drug Design and Discovery CRC Press p 429 ISBN 978 1 4200 6322 6 Sneader Walter 2005 23 Antibiotic analogues Drug Discovery A History Chichester West Sussex Wiley p 337 ISBN 978 0 471 89979 2 Fisher Jed 2012 2 B Lactams resistant to hydrolysis by the b lactamases In Bryan L ed Antimicrobial Drug Resistance Orlando Academic press p 51 ISBN 978 0 12 138120 2 a b Ravenscraft David J Long William F 2007 Paths to creating value in pharmaceutical mergers In Kaplan Steven N ed Mergers and Productivity University of Chicago Press pp 306 310 ISBN 978 0 226 42431 6 MRC Annual Report Medical Research Council 1994 p 26 The Vaccine Taskforce objectives and membership of steering group PDF GOV UK Retrieved 30 November 2021 Dickson David 1 December 1998 Research trio to develop new vaccines Nature Medicine 4 12 1349 doi 10 1038 3927 ISSN 1546 170X PMID 9846561 S2CID 33610131 Brier Jennifer 2009 Infectious Ideas U S Political Responses to the AIDS Crisis University of North Carolina Press p 193 ISBN 978 0 8078 3314 8 a b Gay Hannah Scientific Firm World 2013 The Silwood Circle A History of Ecology and the Making of Scientific Careers in Late Twentieth Century Britain World Scientific p 183 ISBN 978 1 84816 991 3 a b c Rugman Alan M 2005 The Regional Multinationals MNEs and Global Strategic Management Cambridge Cambridge University Press p 123 ISBN 0 521 84265 4 Fuller Steve 2009 1 Introduction the place of intellectual life The Sociology of Intellectual Life The Career of the Mind in and Around Academy Los Angeles SAGE p 15 ISBN 978 1 4129 2838 0 Richard Sykes Royal Society royalsociety org Retrieved 30 November 2021 Library and Archive Catalogue EC 1997 33 Sir Richard Brook London The Royal Society a b c d e Sir Richard Sykes 1942 www rigb org Higher Education in the learning society Main Report Education England Archived from the original on 11 February 2015 Retrieved 10 February 2015 Heaman Elsbeth 2003 14 Science and strategy the merger with Imperial College St Mary s The History of a London Teaching Hospital Montreal Liverpool University Press p 417 ISBN 0 85323 968 1 a b c Richard Sykes PDF Imperial College London London Imperial College Retrieved 9 November 2021 Evatt M A C Brodhurst E K 2002 Sharing Experience in Engineering Design SEED 2002 John Wiley amp Sons ISBN 978 1 86058 397 1 A Rector to remember Imperial Matters Alumni Magazine 32 10 13 2008 Gay Hannah 2007 15 The expanding college 1985 2001 Part 1 Governance and the medical school mergers History Of Imperial College London 1907 2007 The Higher Education And Research In Science Technology And Medicine London Imperial College Press p 604 ISBN 978 1 86094 708 7 a b Harte Negley North John Brewis Georgina 21 May 2018 The World of UCL UCL Press ISBN 9781787352933 Opposition ends Imperial and UCL merger dream The Guardian 18 November 2002 Retrieved 13 April 2021 The future sustainability of the higher education sector international aspects eighth report of session 2006 07 Vol 2 Oral and written evidence The Stationery Office 2007 p 43 ISBN 978 0 215 03600 1 Devaney Sarah 2013 Stem Cell Research and the Collaborative Regulation of Innovation Abingdon Oxford Routledge p 39 ISBN 978 0 415 52130 7 House of Commons Hansard Debates for 7 Mar 2005 pt 29 publications parliament uk Parliament co uk Retrieved 30 November 2021 Furcht Leo Hoffman William 2011 The Stem Cell Dilemma The Scientific Breakthroughs Ethical Concerns Political Tensions and Hope Surrounding Stem Cell Research in Dutch Simon and Schuster p 230 ISBN 978 1 62872 181 2 Bawden Tom 10 June 2011 Sir Richard Sykes voted out but not down The Guardian Retrieved 2 December 2021 Randeep Ramesh 26 May 2010 NHS London chief Richard Sykes resigns in care review row The Guardian Retrieved 27 May 2010 Wise Jacqui 5 June 2010 BMJ News PDF British Medical Journal 340 1216 1217 ENRC Management Archived 28 May 2011 at the Wayback Machine Sir Richard Sykes appointed Chancellor of Brunel University Archived 14 May 2014 at the Wayback Machine Board Changes NetScientific 31 March 2020 Archived from the original on 9 November 2021 Retrieved 9 November 2021 a b Sir Richard Sykes appointed chair of Vaccine Taskforce GOV UK Archived from the original on 13 September 2021 Retrieved 25 October 2021 UK COVID 19 Update Nurse Gives Historic Jab Oxford Vaccine Phase 3 Results Medscape Archived from the original on 16 January 2021 Retrieved 12 November 2021 Tax cuts yes but first reform public services Daily Telegraph 3 September 2006 Advisory Council of the Campaign for Science and Engineering Archived from the original on 28 August 2010 Retrieved 11 February 2011 Our Team King Edward VII s Hospital Archived from the original on 16 May 2022 Retrieved 25 October 2021 Sir Richard Sykes DSc 1994 Archived 3 March 2016 at the Wayback Machine Fellow Sir Richard Sykes FRS FMedSci website of the Academy of Medical Sciences Garrod Lecture amp Medal The British Society for Antimicrobial Chemotherapy 2021 Archived from the original on 2 November 2021 Retrieved 2 November 2021 Sykes R 1 September 2010 The 2009 Garrod Lecture The evolution of antimicrobial resistance a Darwinian perspective Journal of Antimicrobial Chemotherapy 65 9 1842 1852 doi 10 1093 jac dkq217 PMID 20573657 External links editRichard Sykes s publications indexed by the Scopus bibliographic database subscription required Academic offices Preceded byRonald Oxburgh Rector of Imperial College London2000 2008 Succeeded byRoy Anderson Preceded byJohn Wakeham Baron Wakeham Chancellor of Brunel University2013 present Succeeded byIncumbent Retrieved from https en wikipedia org w index php title Richard Sykes microbiologist amp oldid 1215401498, wikipedia, wiki, book, books, library,

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