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Peter Doherty (immunologist)

April 10, 2024

Peter Charles Doherty AC FRS FMedSci (born 15 October 1940)[3] is an Australian immunologist and Nobel laureate.[4] He received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine jointly with Rolf M. Zinkernagel[5] in 1996 and was named Australian of the Year in 1997.[6] In the Australia Day Honours of 1997, he was named a Companion of the Order of Australia for his work with Zinkernagel.[7] He is also a National Trust Australian Living Treasure.[8] In 2009 as part of the Q150 celebrations, Doherty's immune system research was announced as one of the Q150 Icons of Queensland for its role as an iconic "innovation and invention".[9]

Peter Doherty

AC FRS FMedSci
Born
Peter Charles Doherty

15 October 1940 (1940-10-15) (age 83)[3]
Brisbane, Queensland, Australia
NationalityAustralian
Alma mater
Known forMajor histocompatibility complex
AwardsPaul Ehrlich and Ludwig Darmstaedter Prize (1983)
Nobel Prize in Physiology or Medicine (1996)
Australian of the Year (1997)
Leeuwenhoek Lecture (1999)[1]
Scientific career
FieldsMedicine
Immunology
InstitutionsJohn Curtin School of Medical Research
Australian National University
ThesisStudies in the experimental pathology of louping-ill encephalitis (1970)
Doctoral advisorG. L. Montgomery
J. T. Stamp[2]

Early life and education edit

Peter Charles Doherty was born in the Brisbane suburb of Sherwood on 15 October 1940, to Eric Charles Doherty and Linda Doherty (née Byford).[10][11] He grew up in Oxley,[12] and attended Indooroopilly State High School (which now has a lecture theatre named after him).

After receiving his bachelor's degree in veterinary science in 1962 from the University of Queensland, he was a rural veterinary officer for the Queensland Department of Agriculture and Stock before taking up laboratory-based work at the Department's Animal Research Institute.[13] There he met microbiology graduate Penelope Stephens and they were married in 1965.[13] Doherty received his master's degree in veterinary science in 1966 from the University of Queensland.[14]

He obtained his PhD in pathology [15] in 1970 from the University of Edinburgh, Scotland,[2] then returned to Australia to continue his research at the John Curtin School of Medical Research within the Australian National University in Canberra.

Research and career edit

Doherty's research focuses[16][17] on the immune system and his Nobel Prize work described how the body's immune cells protect against viruses. He and Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognise their target antigens in combination with major histocompatibility complex (MHC) proteins.[18]

Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot reproduce. Zinkernagel and Doherty discovered that, in order for killer T cells to recognise infected cells, they had to recognise two molecules on the surface of the cell – not only the virus antigen, but also a molecule of the major histocompatibility complex (MHC). This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too.[19]

Awards and honours edit

Doherty was elected a Fellow of the Royal Society (FRS) in 1987.[1] In 1997, he received the Golden Plate Award of the American Academy of Achievement.[20] He is the patron of the eponymous Peter Doherty Institute for Infection and Immunity (Doherty Institute), a joint venture between the University of Melbourne and Melbourne Health. It houses a group of infection and immunology experts, including Director Professor Sharon Lewin, who are charged with leading the battle against infectious diseases in humans. This became operational in 2014.[21] He became an Honorary Fellow of the Academy of Medical Sciences (FMedSci) in 2015.[22] In the same year he was elected Fellow of the Australian Academy of Health and Medical Sciences (FAHMS).[23] In April 2017 he was inducted as a Fellow of the Royal Society of Victoria (FRSV).[24]

John Monash Science School,[25] Moreton Bay Boys College,[26] and Murrumba State Secondary College[27] each have a house named after him.

Non academic publications edit

  • Doherty, Peter (2022). Empire, war, tennis and me. [S.l.]: MELBOURNE UNIV PRESS. ISBN 978-0-522-87856-1. OCLC 1302578051.
  • Doherty, Peter (2021). An insider's plague year. Carlton, Vic. ISBN 978-0-522-87751-9. OCLC 1258120542.{{cite book}}: CS1 maint: location missing publisher (link)
  • Doherty, P. C. (2018). The incidental tourist : on the road with a globetrotting Nobel Prize winner. Carlton, Victoria. ISBN 978-0-522-87172-2. OCLC 1048246796.{{cite book}}: CS1 maint: location missing publisher (link)
  • Doherty, P. C. (2015). The knowledge wars. Carlton, Vic. ISBN 978-0-522-86285-0. OCLC 908193218.{{cite book}}: CS1 maint: location missing publisher (link)[28]
  • Doherty, P. C. (2013). Pandemics : what everyone needs to know. Oxford. ISBN 978-0-19-989811-4. OCLC 851695304.{{cite book}}: CS1 maint: location missing publisher (link)
  • Doherty, Peter (2012). Sentinel chickens : what birds can tell us about our health and our world. Carlton, Vic.: Melbourne University Publishing. ISBN 978-0-522-86110-5. OCLC 781878873.
  • Doherty, Peter Charles (2007). A light history of hot air. Carlton, Vic.: Melbourne University Press. ISBN 978-0-522-85407-7. OCLC 225591871.
  • Doherty, P. C. (2006). The beginner's guide to winning the Nobel prize : a life in science. New York: Columbia University Press. ISBN 978-0-231-13896-3. OCLC 232160284.

Personal life edit

As of 2021, Peter Doherty and his wife Penny live in Melbourne.[29] They have two sons, Michael, a neurologist working in the United States,[30] and James, a Melbourne-based barrister,[13] and six grandchildren.[31] He gained a renewed level of fame in 2020 during the COVID-19 pandemic when he accidentally tweeted the phrase 'Dan Murphy opening hours' instead of performing a web search for it.[32][33]

Doherty currently[when?] spends three months of the year conducting research at St. Jude Children's Research Hospital in Memphis, Tennessee, where he is a faculty member at the University of Tennessee Health Science Center through the College of Medicine.[34] For the other 9 months of the year, he works in the Department of Microbiology and Immunology at the University of Melbourne, Victoria.

References edit

  1. ^ a b "Peter Doherty". royalsociety.org. from the original on 12 June 2018. Retrieved 12 June 2018.
  2. ^ a b Doherty, Peter Charles (1970). Studies in the experimental pathology of louping-ill encephalitis (PhD thesis). hdl:1842/17153. EThOS 699841.  
  3. ^ a b Anon (2017). "Doherty, Prof. Peter Charles". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.13865. (Subscription or UK public library membership required.)
  4. ^ "Laureate Professor Peter Doherty AC". University of Queensland. 2 November 2015. from the original on 2 November 2018. Retrieved 2 November 2018.
  5. ^ "Peter Doherty - Nobel Prize Inspiration Initiative". Nobel Prize Inspiration Initiative. from the original on 28 September 2013. Retrieved 26 September 2013.
  6. ^ Lewis, Wendy (2010). Australians of the Year. Pier 9 Press. ISBN 978-1-74196-809-5.
  7. ^ "It's an Honour - Honours - Search Australian Honours". www.itsanhonour.gov.au. from the original on 29 January 2019. Retrieved 30 July 2009.
  8. ^ "Peter C. Doherty, PhD". from the original on 5 September 2015. Retrieved 30 August 2015.
  9. ^ Bligh, Anna (10 June 2009). . Queensland Government. Archived from the original on 24 May 2017. Retrieved 24 May 2017.
  10. ^ "Births". The Courier-Mail. 21 October 1940. p. 6, col. 1. Retrieved 2 September 2021.
  11. ^ "Peter C. Doherty - Biographical". from the original on 22 December 2016. Retrieved 7 March 2017.
  12. ^ . New Scientist. 23 November 1996. Archived from the original on 23 October 2020.
  13. ^ a b c Collis, Brad. "Survival of the Cells". Innovation Intelligence. Archived from the original on 2 September 2021. Retrieved 2 September 2021.
  14. ^ "Laureate Professor Peter Doherty AC". University of Queensland. 2 November 2015. from the original on 2 November 2018. Retrieved 4 November 2018.
  15. ^ . Archived from the original on 25 September 2020.
  16. ^ Peter Doherty publications indexed by Google Scholar  
  17. ^ Peter Doherty publications indexed by the Scopus bibliographic database. (subscription required)
  18. ^ Hawkes, Nigel (8 October 1996). "Immunity scientists win Nobel prize". The Times (London). p. 13.
  19. ^ "The Nobel Prize in Physiology or Medicine 1996". from the original on 25 October 2018. Retrieved 25 October 2018.
  20. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  21. ^ "Peter Doherty Institute, University of Melbourne". from the original on 6 July 2014. Retrieved 8 July 2014.
  22. ^ "Report of the Annual Fellows' Meeting 2015 - The Academy of Medical Sciences". www.acmedsci.ac.uk. from the original on 4 March 2016. Retrieved 7 January 2016.
  23. ^ "Fellowship | AAHMS – Australian Academy of Health and Medical Sciences". www.aahms.org. from the original on 26 June 2018. Retrieved 26 June 2018.
  24. ^ "Elected Fellows of the Royal Society of Victoria - The Royal Society of Victoria". The Royal Society of Victoria. from the original on 7 July 2017. Retrieved 27 June 2018.
  25. ^ "House Programs". www.jmss.vic.edu.au. from the original on 26 June 2018. Retrieved 26 June 2018.
  26. ^ "Moreton Bay Boys' College School House Program". Moreton Bay Boys' College. from the original on 26 June 2018. Retrieved 26 June 2018.
  27. ^ "Murrumba State Secondary College". murrumbassc.eq.edu.au. 15 September 2011. Retrieved 28 January 2019.
  28. ^ Alberici, Emma (25 August 2015), Interview: Peter Doherty, Nobel Prize Winner for Medicine in 1996, Australian Broadcasting Corporation, retrieved 27 August 2022
  29. ^ Willis, Olivia (13 July 2021). . ABC News. Archived from the original on 13 July 2021.
  30. ^ Walker, Jamie (4 April 2020). "Coronavirus is just as lethal as Spanish flu, Nobel laureate Peter Doherty warns". The Australian. Archived from the original on 4 September 2021.
  31. ^ Durkin, Patrick (8 May 2020). "'I'm 79, I won the Nobel Prize and I don't give a s---'". Australian Financial Review. Archived from the original on 10 May 2020.
  32. ^ Doherty, Peter [@ProfPCDoherty] (27 April 2020). "Dan Murphy opening hours" (Tweet). Retrieved 9 January 2024 – via Twitter.
  33. ^ McGowan, Michael (27 April 2020). "Nobel prize-winning immunologist accidentally asks Twitter when he'll be able to get a drink". The Guardian. Retrieved 9 January 2024.
  34. ^ . Archived from the original on 2 April 2015.

External links edit

 
Wikimedia Commons has media related to Peter C. Doherty.
  • Nobel Prize biographical information (including his Nobel Lecture on "Cell Mediated Immunity in Virus Infections")
  • Appearances on C-SPAN
  • from This Week in Science 5 September 2005 broadcast
  • , by Margaret Wertheim, Cosmos magazine, October 2006
  • Peter Doherty delivers the opening address at the 2009 Melbourne Festival of Ideas on ABC Fora (video)
  • Peter Doherty addresses the Vic Skeptics – Scepticism, Denial and Ignorance: There is a Difference on YouTube (video)

  This article incorporates text by Royal Society available under the CC BY 4.0 license.

April 10, 2024
peter, doherty, immunologist, peter, charles, doherty, fmedsci, born, october, 1940, australian, immunologist, nobel, laureate, received, albert, lasker, award, basic, medical, research, 1995, nobel, prize, physiology, medicine, jointly, with, rolf, zinkernage. Peter Charles Doherty AC FRS FMedSci born 15 October 1940 3 is an Australian immunologist and Nobel laureate 4 He received the Albert Lasker Award for Basic Medical Research in 1995 the Nobel Prize in Physiology or Medicine jointly with Rolf M Zinkernagel 5 in 1996 and was named Australian of the Year in 1997 6 In the Australia Day Honours of 1997 he was named a Companion of the Order of Australia for his work with Zinkernagel 7 He is also a National Trust Australian Living Treasure 8 In 2009 as part of the Q150 celebrations Doherty s immune system research was announced as one of the Q150 Icons of Queensland for its role as an iconic innovation and invention 9 Peter DohertyAC FRS FMedSciBornPeter Charles Doherty15 October 1940 1940 10 15 age 83 3 Brisbane Queensland AustraliaNationalityAustralianAlma materUniversity of Queensland BVSc MVSc DVSc University of Edinburgh PhD Known forMajor histocompatibility complexAwardsPaul Ehrlich and Ludwig Darmstaedter Prize 1983 Nobel Prize in Physiology or Medicine 1996 Australian of the Year 1997 Leeuwenhoek Lecture 1999 1 Scientific careerFieldsMedicineImmunologyInstitutionsJohn Curtin School of Medical ResearchAustralian National UniversityThesisStudies in the experimental pathology of louping ill encephalitis 1970 Doctoral advisorG L Montgomery J T Stamp 2 Contents 1 Early life and education 2 Research and career 3 Awards and honours 4 Non academic publications 5 Personal life 6 References 7 External linksEarly life and education editPeter Charles Doherty was born in the Brisbane suburb of Sherwood on 15 October 1940 to Eric Charles Doherty and Linda Doherty nee Byford 10 11 He grew up in Oxley 12 and attended Indooroopilly State High School which now has a lecture theatre named after him After receiving his bachelor s degree in veterinary science in 1962 from the University of Queensland he was a rural veterinary officer for the Queensland Department of Agriculture and Stock before taking up laboratory based work at the Department s Animal Research Institute 13 There he met microbiology graduate Penelope Stephens and they were married in 1965 13 Doherty received his master s degree in veterinary science in 1966 from the University of Queensland 14 He obtained his PhD in pathology 15 in 1970 from the University of Edinburgh Scotland 2 then returned to Australia to continue his research at the John Curtin School of Medical Research within the Australian National University in Canberra Research and career editDoherty s research focuses 16 17 on the immune system and his Nobel Prize work described how the body s immune cells protect against viruses He and Rolf Zinkernagel the co recipient of the 1996 Nobel Prize in Physiology or Medicine discovered how T cells recognise their target antigens in combination with major histocompatibility complex MHC proteins 18 Viruses infect host cells and reproduce inside them Killer T cells destroy those infected cells so that the viruses cannot reproduce Zinkernagel and Doherty discovered that in order for killer T cells to recognise infected cells they had to recognise two molecules on the surface of the cell not only the virus antigen but also a molecule of the major histocompatibility complex MHC This recognition was done by a T cell receptor on the surface of the T cell The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too 19 Awards and honours editDoherty was elected a Fellow of the Royal Society FRS in 1987 1 In 1997 he received the Golden Plate Award of the American Academy of Achievement 20 He is the patron of the eponymous Peter Doherty Institute for Infection and Immunity Doherty Institute a joint venture between the University of Melbourne and Melbourne Health It houses a group of infection and immunology experts including Director Professor Sharon Lewin who are charged with leading the battle against infectious diseases in humans This became operational in 2014 21 He became an Honorary Fellow of the Academy of Medical Sciences FMedSci in 2015 22 In the same year he was elected Fellow of the Australian Academy of Health and Medical Sciences FAHMS 23 In April 2017 he was inducted as a Fellow of the Royal Society of Victoria FRSV 24 John Monash Science School 25 Moreton Bay Boys College 26 and Murrumba State Secondary College 27 each have a house named after him Non academic publications editDoherty Peter 2022 Empire war tennis and me S l MELBOURNE UNIV PRESS ISBN 978 0 522 87856 1 OCLC 1302578051 Doherty Peter 2021 An insider s plague year Carlton Vic ISBN 978 0 522 87751 9 OCLC 1258120542 a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link Doherty P C 2018 The incidental tourist on the road with a globetrotting Nobel Prize winner Carlton Victoria ISBN 978 0 522 87172 2 OCLC 1048246796 a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link Doherty P C 2015 The knowledge wars Carlton Vic ISBN 978 0 522 86285 0 OCLC 908193218 a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link 28 Doherty P C 2013 Pandemics what everyone needs to know Oxford ISBN 978 0 19 989811 4 OCLC 851695304 a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link Doherty Peter 2012 Sentinel chickens what birds can tell us about our health and our world Carlton Vic Melbourne University Publishing ISBN 978 0 522 86110 5 OCLC 781878873 Doherty Peter Charles 2007 A light history of hot air Carlton Vic Melbourne University Press ISBN 978 0 522 85407 7 OCLC 225591871 Doherty P C 2006 The beginner s guide to winning the Nobel prize a life in science New York Columbia University Press ISBN 978 0 231 13896 3 OCLC 232160284 Personal life editAs of 2021 update Peter Doherty and his wife Penny live in Melbourne 29 They have two sons Michael a neurologist working in the United States 30 and James a Melbourne based barrister 13 and six grandchildren 31 He gained a renewed level of fame in 2020 during the COVID 19 pandemic when he accidentally tweeted the phrase Dan Murphy opening hours instead of performing a web search for it 32 33 Doherty currently when spends three months of the year conducting research at St Jude Children s Research Hospital in Memphis Tennessee where he is a faculty member at the University of Tennessee Health Science Center through the College of Medicine 34 For the other 9 months of the year he works in the Department of Microbiology and Immunology at the University of Melbourne Victoria References edit a b Peter Doherty royalsociety org Archived from the original on 12 June 2018 Retrieved 12 June 2018 a b Doherty Peter Charles 1970 Studies in the experimental pathology of louping ill encephalitis PhD thesis hdl 1842 17153 EThOS 699841 nbsp a b Anon 2017 Doherty Prof Peter Charles Who s Who online Oxford University Press ed Oxford A amp C Black doi 10 1093 ww 9780199540884 013 13865 Subscription or UK public library membership required Laureate Professor Peter Doherty AC University of Queensland 2 November 2015 Archived from the original on 2 November 2018 Retrieved 2 November 2018 Peter Doherty Nobel Prize Inspiration Initiative Nobel Prize Inspiration Initiative Archived from the original on 28 September 2013 Retrieved 26 September 2013 Lewis Wendy 2010 Australians of the Year Pier 9 Press ISBN 978 1 74196 809 5 It s an Honour Honours Search Australian Honours www itsanhonour gov au Archived from the original on 29 January 2019 Retrieved 30 July 2009 Peter C Doherty PhD Archived from the original on 5 September 2015 Retrieved 30 August 2015 Bligh Anna 10 June 2009 PREMIER UNVEILS QUEENSLAND S 150 ICONS Queensland Government Archived from the original on 24 May 2017 Retrieved 24 May 2017 Births The Courier Mail 21 October 1940 p 6 col 1 Retrieved 2 September 2021 Peter C Doherty Biographical Archived from the original on 22 December 2016 Retrieved 7 March 2017 Antipodes Science Peter Doherty downloaded New Scientist 23 November 1996 Archived from the original on 23 October 2020 a b c Collis Brad Survival of the Cells Innovation Intelligence Archived from the original on 2 September 2021 Retrieved 2 September 2021 Laureate Professor Peter Doherty AC University of Queensland 2 November 2015 Archived from the original on 2 November 2018 Retrieved 4 November 2018 The American Association of Immunologists Peter C Doherty Archived from the original on 25 September 2020 Peter Doherty publications indexed by Google Scholar nbsp Peter Doherty publications indexed by the Scopus bibliographic database subscription required Hawkes Nigel 8 October 1996 Immunity scientists win Nobel prize The Times London p 13 The Nobel Prize in Physiology or Medicine 1996 Archived from the original on 25 October 2018 Retrieved 25 October 2018 Golden Plate Awardees of the American Academy of Achievement www achievement org American Academy of Achievement Peter Doherty Institute University of Melbourne Archived from the original on 6 July 2014 Retrieved 8 July 2014 Report of the Annual Fellows Meeting 2015 The Academy of Medical Sciences www acmedsci ac uk Archived from the original on 4 March 2016 Retrieved 7 January 2016 Fellowship AAHMS Australian Academy of Health and Medical Sciences www aahms org Archived from the original on 26 June 2018 Retrieved 26 June 2018 Elected Fellows of the Royal Society of Victoria The Royal Society of Victoria The Royal Society of Victoria Archived from the original on 7 July 2017 Retrieved 27 June 2018 House Programs www jmss vic edu au Archived from the original on 26 June 2018 Retrieved 26 June 2018 Moreton Bay Boys College School House Program Moreton Bay Boys College Archived from the original on 26 June 2018 Retrieved 26 June 2018 Murrumba State Secondary College murrumbassc eq edu au 15 September 2011 Retrieved 28 January 2019 Alberici Emma 25 August 2015 Interview Peter Doherty Nobel Prize Winner for Medicine in 1996 Australian Broadcasting Corporation retrieved 27 August 2022 Willis Olivia 13 July 2021 Nobel prize winner Peter Doherty on navigating COVID 19 and life in lockdown ABC News Archived from the original on 13 July 2021 Walker Jamie 4 April 2020 Coronavirus is just as lethal as Spanish flu Nobel laureate Peter Doherty warns The Australian Archived from the original on 4 September 2021 Durkin Patrick 8 May 2020 I m 79 I won the Nobel Prize and I don t give a s Australian Financial Review Archived from the original on 10 May 2020 Doherty Peter ProfPCDoherty 27 April 2020 Dan Murphy opening hours Tweet Retrieved 9 January 2024 via Twitter McGowan Michael 27 April 2020 Nobel prize winning immunologist accidentally asks Twitter when he ll be able to get a drink The Guardian Retrieved 9 January 2024 UTHSC people search Archived from the original on 2 April 2015 External links edit nbsp Wikimedia Commons has media related to Peter C Doherty Nobel Prize biographical information including his Nobel Lecture on Cell Mediated Immunity in Virus Infections Appearances on C SPAN Radio Interview from This Week in Science 5 September 2005 broadcast Winning a Nobel easy as wrestling a pig by Margaret Wertheim Cosmos magazine October 2006 Peter Doherty delivers the opening address at the 2009 Melbourne Festival of Ideas on ABC Fora video Peter Doherty addresses the Vic Skeptics Scepticism Denial and Ignorance There is a Difference on YouTube video nbsp This article incorporates text by Royal Society available under the CC BY 4 0 license Retrieved from https en wikipedia org w index php title Peter Doherty immunologist amp oldid 1194501408, wikipedia, wiki, book, books, library,

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