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Wikipedia

Miscarriage

April 20, 2023

For usage in law, see Miscarriage of justice.

Miscarriage, also known in medical terms as a spontaneous abortion and pregnancy loss, is the death of an embryo or fetus before it is able to survive independently.[1][4] Miscarriage before 6 weeks of gestation is defined by ESHRE as biochemical loss.[13][14] Once ultrasound or histological evidence shows that a pregnancy has existed, the used term is clinical miscarriage, which can be early before 12 weeks and late between 12-21 weeks.[13] Fetal death after 20 weeks of gestation is also known as a stillbirth.[15] The most common symptom of a miscarriage is vaginal bleeding with or without pain.[1] Sadness, anxiety, and guilt may occur afterwards.[3][16] Tissue and clot-like material may leave the uterus and pass through and out of the vagina.[17] Recurrent miscarriage (also referred to medically as Recurrent Spontaneous Abortion or RSA)[18] may also be considered a form of infertility.[19]

Miscarriage
Other namesspontaneous abortion, early pregnancy loss
An ultrasound showing a gestational sac containing a yolk sac but no embryo
SpecialtyObstetrics and Gynaecology, Neonatology, Pediatrics
SymptomsVaginal bleeding with or without pain[1]
ComplicationsInfection, bleeding,[2] sadness, anxiety, guilt[3]
Usual onsetBefore 20 weeks of pregnancy[4]
CausesChromosomal abnormalities,[1][5] uterine abnormalities[6]
Risk factorsBeing an older parent, previous miscarriage, exposure to tobacco smoke, obesity, diabetes, autoimmune diseases, drug or alcohol use[7][8][9]
Diagnostic methodPhysical examination, human chorionic gonadotropin, ultrasound[10]
Differential diagnosisEctopic pregnancy, implantation bleeding.[1]
PreventionPrenatal care[11]
TreatmentExpectant management, vacuum aspiration, emotional support[8][12]
Medicationmisoprostol
Frequency10–50% of pregnancies[1][7]

Risk factors for miscarriage include being an older parent, previous miscarriage, exposure to tobacco smoke, obesity, diabetes, thyroid problems, and drug or alcohol use.[7][8] About 80% of miscarriages occur in the first 12 weeks of pregnancy (the first trimester).[1] The underlying cause in about half of cases involves chromosomal abnormalities.[5][1] Diagnosis of a miscarriage may involve checking to see if the cervix is open or sealed, testing blood levels of human chorionic gonadotropin (hCG), and an ultrasound.[10] Other conditions that can produce similar symptoms include an ectopic pregnancy and implantation bleeding.[1]

Prevention is occasionally possible with good prenatal care.[11] Avoiding drugs, alcohol, infectious diseases, and radiation may decrease the risk of miscarriage.[11] No specific treatment is usually needed during the first 7 to 14 days.[8][12] Most miscarriages will complete without additional interventions.[8] Occasionally the medication misoprostol or a procedure such as vacuum aspiration is used to remove the remaining tissue.[12][20] Women who have a blood type of rhesus negative (Rh negative) may require Rho(D) immune globulin.[8] Pain medication may be beneficial.[12] Emotional support may help with processing the loss.[12]

Miscarriage is the most common complication of early pregnancy.[21] Among women who know they are pregnant, the miscarriage rate is roughly 10% to 20%, while rates among all fertilisation is around 30% to 50%.[1][7] In those under the age of 35 the risk is about 10% while it is about 45% in those over the age of 40.[1] Risk begins to increase around the age of 30.[7] About 5% of women have two miscarriages in a row.[22] Some recommend not using the term "abortion" in discussions with those experiencing a miscarriage in an effort to decrease distress.[23] In Britain, the term "miscarriage" has replaced any use of the term "spontaneous abortion" in relation to pregnancy loss and in response to complaints of insensitivity towards women who had suffered such loss.[24] An additional benefit of this change is reducing confusion among medical laymen, who may not realize that the term "spontaneous abortion" refers to a naturally-occurring medical phenomenon, and not the intentional termination of pregnancy.

Signs and symptoms

Signs of a miscarriage include vaginal spotting, abdominal pain, cramping, and fluid, blood clots, and tissue passing from the vagina.[25][26][27] Bleeding can be a symptom of miscarriage, but many women also have bleeding in early pregnancy and do not miscarry.[28] Bleeding during the first half of pregnancy may be referred to as a threatened miscarriage.[29] Of those who seek treatment for bleeding during pregnancy, about half will miscarry.[30] Miscarriage may be detected during an ultrasound exam, or through serial human chorionic gonadotropin (HCG) testing.

Risk factors

Further information: List of miscarriage risks

Miscarriage may occur for many reasons, not all of which can be identified. Risk factors are those things that increase the likelihood of having a miscarriage but do not necessarily cause a miscarriage. Up to 70 conditions,[1][5][31][32][33][34] infections,[35][36][37] medical procedures,[38][39][40] lifestyle factors,[7][8][41][42][43] occupational exposures,[11][44][45] chemical exposure,[45] and shift work are associated with increased risk for miscarriage.[46] Some of these risks include endocrine, genetic, uterine, or hormonal abnormalities, reproductive tract infections, and tissue rejection caused by an autoimmune disorder.[47]

Trimesters

First trimester

Chromosomal abnormalities found in first trimester miscarriages
Description Proportion of total
Normal 45–55%
Autosomal trisomy 22–32%
Monosomy X (45, X) 5–20%
Triploidy 6–8%
Structural abnormality of
the chromosome 		2%
Double or triple trisomy 0.7–2.0%[48]
Translocation Unknown[49]

Most clinically apparent miscarriages (two-thirds to three-quarters in various studies) occur during the first trimester.[1][35][50][51] About 30% to 40% of all fertilized eggs miscarry, often before the pregnancy is known.[1] The embryo typically dies before the pregnancy is expelled; bleeding into the decidua basalis and tissue necrosis causes uterine contractions to expel the pregnancy.[51] Early miscarriages can be due to a developmental abnormality of the placenta or other embryonic tissues. In some instances an embryo does not form but other tissues do. This has been called a "blighted ovum".[52][53][48]

Successful implantation of the zygote into the uterus is most likely eight to ten days after fertilization. If the zygote has not implanted by day ten, implantation becomes increasingly unlikely in subsequent days.[54]

A chemical pregnancy is a pregnancy that was detected by testing but ends in miscarriage before or around the time of the next expected period.[55]

Chromosomal abnormalities are found in more than half of embryos miscarried in the first 13 weeks. Half of embryonic miscarriages (25% of all miscarriages) have an aneuploidy (abnormal number of chromosomes).[56] Common chromosome abnormalities found in miscarriages include an autosomal trisomy (22–32%), monosomy X (5–20%), triploidy (6–8%), tetraploidy (2–4%), or other structural chromosomal abnormalities (2%).[51] Genetic problems are more likely to occur with older parents; this may account for the higher rates observed in older women.[57]

Luteal phase progesterone deficiency may or may not be a contributing factor to miscarriage.[58]

Second and third trimesters

Second trimester losses may be due to maternal factors such as uterine malformation, growths in the uterus (fibroids), or cervical problems.[35] These conditions also may contribute to premature birth.[50] Unlike first-trimester miscarriages, second-trimester miscarriages are less likely to be caused by a genetic abnormality; chromosomal aberrations are found in a third of cases.[51] Infection during the third trimester can cause a miscarriage.[35]

Age

Further information: Advanced maternal age

The age of the pregnant woman is a significant risk factor. Miscarriage rates increase steadily with age, with more substantial increases after age 35.[59] In those under the age of 35 the risk is about 10% while it is about 45% in those over the age of 40.[1] Risk begins to increase around the age of 30.[7] Paternal age is associated with increased risk.[60]

Obesity, eating disorders and caffeine

Not only is obesity associated with miscarriage; it can result in sub-fertility and other adverse pregnancy outcomes. Recurrent miscarriage is also related to obesity. Women with bulimia nervosa and anorexia nervosa may have a greater risk for miscarriage. Nutrient deficiencies have not been found to impact miscarriage rates but hyperemesis gravidarum sometimes precedes a miscarriage.[44]

Caffeine consumption also has been correlated to miscarriage rates, at least at higher levels of intake.[35] However, such higher rates are statistically significant only in certain circumstances.

Vitamin supplementation has generally not shown to be effective in preventing miscarriage.[61] Chinese traditional medicine has not been found to prevent miscarriage.[27]

Endocrine disorders

Disorders of the thyroid may affect pregnancy outcomes. Related to this, iodine deficiency is strongly associated with an increased risk of miscarriage.[44] The risk of miscarriage is increased in those with poorly controlled insulin-dependent diabetes mellitus.[44] Women with well-controlled diabetes have the same risk of miscarriage as those without diabetes.[62][63]

Food poisoning

Ingesting food that has been contaminated with listeriosis, toxoplasmosis, and salmonella is associated with an increased risk of miscarriage.[35][19]

Amniocentesis and chorionic villus sampling

Amniocentesis and chorionic villus sampling (CVS) are procedures conducted to assess the fetus. A sample of amniotic fluid is obtained by the insertion of a needle through the abdomen and into the uterus. Chorionic villus sampling is a similar procedure with a sample of tissue removed rather than fluid. These procedures are not associated with pregnancy loss during the second trimester but they are associated with miscarriages and birth defects in the first trimester.[40] Miscarriage caused by invasive prenatal diagnosis (chorionic villus sampling (CVS) and amniocentesis) is rare (about 1%).[39]

Surgery

The effects of surgery on pregnancy are not well-known including the effects of bariatric surgery. Abdominal and pelvic surgery are not risk factors for miscarriage. Ovarian tumours and cysts that are removed have not been found to increase the risk of miscarriage. The exception to this is the removal of the corpus luteum from the ovary. This can cause fluctuations in the hormones necessary to maintain the pregnancy.[64]

Medications

There is no significant association between antidepressant medication exposure and miscarriage.[65] The risk of miscarriage is not likely decreased by discontinuing SSRIs prior to pregnancy.[66] Some available data suggest that there is a small increased risk of miscarriage for women taking any antidepressant,[67][68] though this risk becomes less statistically significant when excluding studies of poor quality.[65][69]

Medicines that increase the risk of miscarriage include:

Immunizations

Immunizations have not been found to cause miscarriage.[71] Live vaccinations, like the MMR vaccine, can theoretically cause damage to the fetus as the live virus can cross the placenta and potentially increase the risk for miscarriage.[72][73] Therefore, the Center for Disease Control (CDC) recommends against pregnant women receiving live vaccinations.[74] However, there is no clear evidence that has shown live vaccinations to increase the risk for miscarriage or fetal abnormalities.[73]

Some live vaccinations include: MMR, varicella, certain types of the influenza vaccine, and rotavirus.[75][76]

Treatments for cancer

Ionizing radiation levels given to a woman during cancer treatment cause miscarriage. Exposure can also impact fertility. The use of chemotherapeutic drugs used to treat childhood cancer increases the risk of future miscarriage.[44]

Pre-existing diseases

Several pre-existing diseases in pregnancy can potentially increase the risk of miscarriage, including diabetes, polycystic ovary syndrome (PCOS), hypothyroidism, certain infectious diseases, and autoimmune diseases. PCOS may increase the risk of miscarriage.[35] Two studies suggested treatment with the drug metformin significantly lowers the rate of miscarriage in women with PCOS,[77][78] but the quality of these studies has been questioned.[79] Metformin treatment in pregnancy has not been shown to be safe.[80] In 2007 the Royal College of Obstetricians and Gynaecologists also recommended against use of the drug to prevent miscarriage.[79] Thrombophilias or defects in coagulation and bleeding were once thought to be a risk in miscarriage but have been subsequently questioned.[81] Severe cases of hypothyroidism increase the risk of miscarriage. The effect of milder cases of hypothyroidism on miscarriage rates has not been established. A condition called luteal phase defect (LPD) is a failure of the uterine lining to be fully prepared for pregnancy. This can keep a fertilized egg from implanting or result in miscarriage.[82]

Mycoplasma genitalium infection is associated with increased risk of preterm birth and miscarriage.[37]

Infections can increase the risk of a miscarriage: rubella (German measles), cytomegalovirus, bacterial vaginosis, HIV, chlamydia, gonorrhoea, syphilis, and malaria.[35]

Immune status

Autoimmunity is a possible cause of recurrent or late-term miscarriages. In the case of an autoimmune-induced miscarriage, the woman's body attacks the growing fetus or prevents normal pregnancy progression.[9][83] Autoimmune disease may cause abnormalities in embryos, which in turn may lead to miscarriage. As an example, Celiac disease increases the risk of miscarriage by an odds ratio of approximately 1.4.[33][34] A disruption in normal immune function can lead to the formation of antiphospholipid antibody syndrome. This will affect the ability to continue the pregnancy, and if a woman has repeated miscarriages, she can be tested for it.[45] Approximately 15% of recurrent miscarriages are related to immunologic factors.[84] The presence of anti-thyroid autoantibodies is associated with an increased risk with an odds ratio of 3.73 and 95% confidence interval 1.8–7.6.[85] Having lupus also increases the risk for miscarriage.[86] Immunohistochemical studies on decidual basalis and chorionic villi found that the imbalance of the immunological environment could be associated with recurrent pregnancy loss.[87]

Anatomical defects and trauma

Fifteen per cent of women who have experienced three or more recurring miscarriages have some anatomical defect that prevents the pregnancy from being carried for the entire term.[88] The structure of the uterus affects the ability to carry a child to term. Anatomical differences are common and can be congenital.[citation needed]

Type of uterine
structure 		Miscarriage rate
associated with defect 		References
Bicornate uterus 40–79% [31][32]
Septate or unicornate 34–88% [31]
Arcuate Unknown [31]
Didelphys 40% [31]
Fibroids Unknown [35]

In some women, cervical incompetence or cervical insufficiency occurs with the inability of the cervix to stay closed during the entire pregnancy.[36][42] It does not cause first trimester miscarriages. In the second trimester, it is associated with an increased risk of miscarriage. It is identified after a premature birth has occurred at about 16–18 weeks into the pregnancy.[88] During the second trimester, major trauma can result in a miscarriage.[34]

Smoking

See also: Smoking and pregnancy

Tobacco (cigarette) smokers have an increased risk of miscarriage.[41][42] There is an increased risk regardless of which parent smokes, though the risk is higher when the gestational mother smokes.[43]

Morning sickness

Nausea and vomiting of pregnancy (NVP, or morning sickness) is associated with a decreased risk. Several possible causes have been suggested for morning sickness but there is still no agreement.[89] NVP may represent a defense mechanism which discourages the mother's ingestion of foods that are harmful to the fetus; according to this model, a lower frequency of miscarriage would be an expected consequence of the different food choices made by women experiencing NVP.[90]

Chemicals and occupational exposure

Chemical and occupational exposures may have some effect in pregnancy outcomes.[91] A cause and effect relationship almost can never be established. Those chemicals that are implicated in increasing the risk for miscarriage are DDT, lead,[92] formaldehyde, arsenic, benzene and ethylene oxide. Video display terminals and ultrasound have not been found to have an effect on the rates of miscarriage. In dental offices where nitrous oxide is used with the absence of anesthetic gas scavenging equipment, there is a greater risk of miscarriage. For women who work with cytotoxic antineoplastic chemotherapeutic agents there is a small increased risk of miscarriage. No increased risk for cosmetologists has been found.[45]

Other

Alcohol increases the risk of miscarriage.[35] Cocaine use increases the rate of miscarriage.[41] Some infections have been associated with miscarriage. These include Ureaplasma urealyticum, Mycoplasma hominis, group B streptococci, HIV-1, and syphilis. Infections of Chlamydia trachomatis, Camphylobacter fetus, and Toxoplasma gondii have not been found to be linked to miscarriage.[51] Subclinical infections of the lining of the womb, commonly known as chronic endometritis are also associated with poor pregnancy outcomes, compared to women with treated chronic endometritis or no chronic endometritis.[93]

Diagnosis

In the case of blood loss, pain, or both, transvaginal ultrasound is performed. If a viable intrauterine pregnancy is not found with ultrasound, blood tests (serial βHCG tests) can be performed to rule out ectopic pregnancy, which is a life-threatening situation.[94][95]

If hypotension, tachycardia, and anemia are discovered, exclusion of an ectopic pregnancy is important.[95]

A miscarriage may be confirmed by an obstetric ultrasound and by the examination of the passed tissue. When looking for microscopic pathologic symptoms, one looks for the products of conception. Microscopically, these include villi, trophoblast, fetal parts, and background gestational changes in the endometrium. When chromosomal abnormalities are found in more than one miscarriage, genetic testing of both parents may be done.[96]

Ultrasound criteria

A review article in The New England Journal of Medicine based on a consensus meeting of the Society of Radiologists in Ultrasound in America (SRU) has suggested that miscarriage should be diagnosed only if any of the following criteria are met upon ultrasonography visualization:[97]

Miscarriage diagnosed Miscarriage suspected References
Crown-rump length of at least 7 mm and no heartbeat. Crown–rump length of less than 7 mm and no heartbeat. [97][98]
Mean gestational sac diameter of at least 25 mm and no embryo. Mean gestational sac diameter of 16–24 mm and no embryo. [97][98]
Absence of embryo with heartbeat at least 2 weeks after an ultrasound scan that showed a gestational sac without a yolk sac. Absence of embryo with heartbeat 7–13 days after an ultrasound scan that showed a gestational sac without a yolk sac. [97][98]
Absence of embryo with heartbeat at least 11 days after an ultrasound scan that showed a gestational sac with a yolk sac. Absence of embryo with heartbeat 7–10 days after a scan that showed a gestational sac with a yolk sac. [97][98]
Absence of embryo at least 6 weeks after last menstrual period. [97][98]
Amniotic sac seen adjacent to yolk sac, and with no visible embryo. [97][98]
Yolk sac of more than 7 mm. [97][98]
Small gestational sac compared to embryo size (less than 5 mm difference between mean sac diameter and crown-rump length). [97][98]

Classification

A threatened miscarriage is any bleeding during the first half of pregnancy.[29] At investigation it may be found that the fetus remains viable and the pregnancy continues without further problems.[medical citation needed]

An anembryonic pregnancy (also called an "empty sac" or "blighted ovum") is a condition where the gestational sac develops normally, while the embryonic part of the pregnancy is either absent or stops growing very early. This accounts for approximately half of miscarriages. All other miscarriages are classified as embryonic miscarriages, meaning that there is an embryo present in the gestational sac. Half of embryonic miscarriages have aneuploidy (an abnormal number of chromosomes).[51]

An inevitable miscarriage occurs when the cervix has already dilated,[99] but the fetus has yet to be expelled. This usually will progress to a complete miscarriage. The fetus may or may not have cardiac activity.

 
Transvaginal ultrasonography after an episode of heavy bleeding in an intrauterine pregnancy that had been confirmed by previous ultrasonography. There is some widening between the uterine walls, but no sign of any gestational sac, thus, in this case, being diagnostic of a complete miscarriage.

A complete miscarriage is when all products of conception have been expelled; these may include the trophoblast, chorionic villi, gestational sac, yolk sac, and fetal pole (embryo); or later in pregnancy the fetus, umbilical cord, placenta, amniotic fluid, and amniotic membrane. The presence of a pregnancy test that is still positive, as well as an empty uterus upon transvaginal ultrasonography, does, however, fulfil the definition of pregnancy of unknown location. Therefore, there may be a need for follow-up pregnancy tests to ensure that there is no remaining pregnancy, including ectopic pregnancy.[citation needed]

 
Transvaginal ultrasonography, with some products of conception in the cervix (to the left in the image) and remnants of a gestational sac by the fundus (to the right in the image), indicating an incomplete miscarriage

An incomplete miscarriage occurs when some products of conception have been passed, but some remains inside the uterus.[100] However, an increased distance between the uterine walls on transvaginal ultrasonography may also simply be an increased endometrial thickness and/or a polyp. The use of a Doppler ultrasound may be better in confirming the presence of significant retained products of conception in the uterine cavity.[101] In cases of uncertainty, ectopic pregnancy must be excluded using techniques like serial beta-hCG measurements.[101]

 
A 13-week fetus without cardiac activity located in the uterus (delayed or missed miscarriage)

A missed miscarriage is when the embryo or fetus has died, but a miscarriage has not yet occurred. It is also referred to as delayed miscarriage, silent miscarriage, or missed abortion.[102][103]

A septic miscarriage occurs when the tissue from a missed or incomplete miscarriage becomes infected, which carries the risk of spreading infection (septicaemia) and can be fatal.[51]

Recurrent miscarriage ("recurrent pregnancy loss" (RPL), "recurrent spontaneous abortion (RSA), or "habitual abortion") is the occurrence of multiple consecutive miscarriages; the exact number used to diagnose recurrent miscarriage varies; however two is the minimum threshold to meet the criteria.[104][51][105] If the proportion of pregnancies ending in miscarriage is 15% and assuming that miscarriages are independent events,[106] then the probability of two consecutive miscarriages is 2.25% and the probability of three consecutive miscarriages is 0.34%. The occurrence of recurrent pregnancy loss is 1%.[106] A large majority (85%) of those who have had two miscarriages will conceive and carry normally afterward.[106]

The physical symptoms of a miscarriage vary according to the length of pregnancy, though most miscarriages cause pain or cramping. The size of blood clots and pregnancy tissue that are passed become larger with longer gestations. After 13 weeks' gestation, there is a higher risk of placenta retention.[107]

Prevention

Prevention of a miscarriage can sometimes be accomplished by decreasing risk factors.[11] This may include good prenatal care, avoiding drugs and alcohol, preventing infectious diseases, and avoiding x-rays.[11] Identifying the cause of the miscarriage may help prevent future pregnancy loss, especially in cases of recurrent miscarriage. Often there is little a person can do to prevent a miscarriage.[11] Vitamin supplementation before or during pregnancy has not been found to affect the risk of miscarriage.[108] Progesterone has been shown to prevent miscarriage in women with 1) vaginal bleeding early in their current pregnancy and 2) a previous history of miscarriage.[109]

Non-modifiable risk factors

Preventing a miscarriage in subsequent pregnancies may be enhanced with assessments of:

Modifiable risk factors

Maintaining a healthy weight and good prenatal care can reduce the risk of miscarriage.[35] Some risk factors can be minimized by avoiding the following:

Management

Women who miscarry early in their pregnancy usually do not require any subsequent medical treatment but they can benefit from support and counseling.[28][112] Most early miscarriages will complete on their own; in other cases, medication treatment or aspiration of the products of conception can be used to remove remaining tissue.[113] While bed rest has been advocated to prevent miscarriage, this has not been found to be of benefit.[114][26] Those who are experiencing or who have experienced a miscarriage benefit from the use of careful medical language. Significant distress can often be managed by the ability of the clinician to clearly explain terms without suggesting that the woman or couple are somehow to blame.[115]

Evidence to support Rho(D) immune globulin after a spontaneous miscarriage is unclear.[116] In the UK, Rho(D) immune globulin is recommended in Rh-negative women after 12 weeks gestational age and before 12 weeks gestational age in those who need surgery or medication to complete the miscarriage.[117]

Methods

No treatment is necessary for a diagnosis of complete miscarriage (so long as ectopic pregnancy is ruled out). In cases of an incomplete miscarriage, empty sac, or missed abortion there are three treatment options: watchful waiting, medical management, and surgical treatment. With no treatment (watchful waiting), most miscarriages (65–80%) will pass naturally within two to six weeks.[118] This treatment avoids the possible side effects and complications of medications and surgery,[119] but increases the risk of mild bleeding, need for unplanned surgical treatment, and incomplete miscarriage. Medical treatment usually consists of using misoprostol (a prostaglandin) alone or in combination with mifepristone pre-treatment.[120] These medications help the uterus to contract and expel the remaining tissue out of the body. This works within a few days in 95% of cases.[118] Vacuum aspiration or sharp curettage can be used, with vacuum aspiration being lower-risk and more common.[118]

Delayed and incomplete miscarriage

In delayed or incomplete miscarriage, treatment depends on the amount of tissue remaining in the uterus. Treatment can include surgical removal of the tissue with vacuum aspiration or misoprostol.[121] Studies looking at the methods of anaesthesia for surgical management of incomplete miscarriage have not shown that any adaptation from normal practice is beneficial.[122]

Induced miscarriage

Further information: Self-induced abortion

An induced abortion may be performed by a qualified healthcare provider for women who cannot continue the pregnancy.[123] Self-induced abortion performed by a woman or non-medical personnel can be dangerous and is still a cause of maternal mortality in some countries. In some locales it is illegal or carries heavy social stigma.[124]

Sex

Some organizations recommend delaying sex after a miscarriage until the bleeding has stopped to decrease the risk of infection.[125] However, there is not sufficient evidence for the routine use of antibiotic to try to avoid infection in incomplete abortion.[126] Others recommend delaying attempts at pregnancy until one period has occurred to make it easier to determine the dates of a subsequent pregnancy.[125] There is no evidence that getting pregnant in that first cycle affects outcomes and an early subsequent pregnancy may actually improve outcomes.[125][127]

Support

Organizations exist that provide information and counselling to help those who have had a miscarriage.[128] Family and friends often conduct a memorial or burial service. Hospitals also can provide support and help memorialize the event. Depending on locale others desire to have a private ceremony.[128] Providing appropriate support with frequent discussions and sympathetic counselling are part of evaluation and treatment. Those who experience unexplained miscarriage can be treated with emotional support.[112][115]

Miscarriage leave

Miscarriage leave is leave of absence in relation to miscarriage. The following countries offer paid or unpaid leave to women who have had a miscarriage.

  • The Philippines – 60 days' fully paid leave for miscarriages (before 20 weeks of gestation) or emergency termination of the pregnancy (on the 20th week or after)[129] The husband of the mother gets seven days' fully paid leave up to the 4th pregnancy.[130]
  • India – six weeks' leave[131]
  • New Zealand – three days' bereavement leave for both parents[132]
  • Mauritius – two weeks' leave[133]
  • Indonesia – six weeks' leave[134]
  • Taiwan – five days, one week or four weeks, depending on how advanced the pregnancy was[135]

Outcomes

Psychological and emotional effects

 
A cemetery for miscarried fetuses, stillborn babies, and babies who have died soon after birth
See also: Miscarriage and grief and Miscarriage and mental illness

Every woman's personal experience of miscarriage is different, and women who have more than one miscarriage may react differently to each event.[136]

In Western cultures since the 1980s,[136] medical providers assume that experiencing a miscarriage "is a major loss for all pregnant women".[112] A miscarriage can result in anxiety, depression or stress for those involved.[95][137][138] It can have an effect on the whole family.[139] Many of those experiencing a miscarriage go through a grieving process.[3][140][141] "Prenatal attachment" often exists that can be seen as parental sensitivity, love and preoccupation directed toward the unborn child.[142] Serious emotional impact is usually experienced immediately after the miscarriage.[3] Some may go through the same loss when an ectopic pregnancy is terminated.[35] In some, the realization of the loss can take weeks. Providing family support to those experiencing the loss can be challenging because some find comfort in talking about the miscarriage while others may find the event painful to discuss. The father can have the same sense of loss. Expressing feelings of grief and loss can sometimes be harder for men. Some women are able to begin planning their next pregnancy after a few weeks of having the miscarriage. For others, planning another pregnancy can be difficult.[128][125] Some facilities acknowledge the loss. Parents can name and hold their infant. They may be given mementos such as photos and footprints. Some conduct a funeral or memorial service. They may express the loss by planting a tree.[143]

Some health organizations recommend that sexual activity be delayed after the miscarriage. The menstrual cycle should resume after about three to four months.[128] Women report that they were dissatisfied with the care they received from physicians and nurses.[144][needs context]

Subsequent pregnancies

Some parents want to try to have a baby very soon after the miscarriage. The decision of trying to become pregnant again can be difficult. Reasons exist that may prompt parents to consider another pregnancy. For older mothers, there may be some sense of urgency. Other parents are optimistic that future pregnancies are likely to be successful. Many are hesitant and want to know about the risk of having another or more miscarriages. Some clinicians recommend that the women have one menstrual cycle before attempting another pregnancy. This is because the date of conception may be hard to determine. Also, the first menstrual cycle after a miscarriage can be much longer or shorter than expected. Parents may be advised to wait even longer if they have experienced late miscarriage or molar pregnancy, or are undergoing tests. Some parents wait for six months based upon recommendations from their health care provider.[125]

Research shows that depression after a miscarriage or stillbirth can continue for years, even after the birth of a subsequent child. Medical professionals are advised to take previous loss of a pregnancy into account when assessing risks for postnatal depression following the birth of a subsequent infant. It is believed that supportive interventions may improve the health outcomes of both the mother and the child.[145]

The risks of having another miscarriage vary according to the cause. The risk of having another miscarriage after a molar pregnancy is very low. The risk of another miscarriage is highest after the third miscarriage. Pre-conception care is available in some locales.[125]

Later cardiovascular disease

There is a significant association between miscarriage and later development of coronary artery disease, but not of cerebrovascular disease.[146][34]

Epidemiology

Among women who know they are pregnant, the miscarriage rate is roughly 10% to 20%, while rates among all fertilized zygotes are around 30% to 50%.[1][7][51][112] A 2012 review found the risk of miscarriage between 5 and 20 weeks from 11% to 22%.[147] Up to the 13th week of pregnancy, the risk of miscarriage each week was around 2%, dropping to 1% in week 14 and reducing slowly between 14 and 20 weeks.[147]

The precise rate is not known because a large number of miscarriages occur before pregnancies become established and before the woman is aware she is pregnant.[147] Additionally, those with bleeding in early pregnancy may seek medical care more often than those not experiencing bleeding.[147] Although some studies attempt to account for this by recruiting women who are planning pregnancies and testing for very early pregnancy, they still are not representative of the wider population.[147]

The prevalence of miscarriage increases with the age of both parents.[147][148][149] In a Danish register-based study where the prevalence of miscarriage was 11%, the prevalence rose from 9% at 22 years of age to 84% by 48 years of age.[150][needs update] Another, later study in 2013 found that when either parent was over the age of 40, the rate of known miscarriages doubled.[51]

In 2010, 50,000 inpatient admissions for miscarriage occurred in the UK.[16]

Terminology

Most affected women and family members refer to miscarriage as the loss of a baby, rather than an embryo or fetus, and healthcare providers are expected to respect and use the language that the person chooses.[115] Clinical terms can suggest blame, increase distress, and even cause anger. Terms that are known to cause distress in those experiencing miscarriage include:

  • abortion (including spontaneous abortion) rather than miscarriage,
  • habitual aborter rather than a woman experiencing recurrent pregnancy loss,
  • products of conception rather than baby,
  • blighted ovum rather than early pregnancy loss or delayed miscarriage,
  • cervical incompetence rather than cervical weakness, and
  • evacuation of retained products of conception (ERPC) rather than surgical management of miscarriage.[115]

Pregnancy loss is a broad term that is used for miscarriage, ectopic and molar pregnancies.[115] The term fetal death applies variably in different countries and contexts, sometimes incorporating weight, and gestational age from 16 weeks in Norway, 20 weeks in the US and Australia, 24 weeks in the UK to 26 weeks in Italy and Spain.[151][152][153] A fetus that died before birth after this gestational age may be referred to as a stillbirth.[151] Under UK law, all stillbirths should be registered,[154] although this does not apply to miscarriages.

History

The medical terminology applied to experiences during early pregnancy has changed over time.[155] Before the 1980s, health professionals used the phrase spontaneous abortion for a miscarriage and induced abortion for a termination of the pregnancy.[155][156] In the late 1980s and 1990s, doctors became more conscious of their language in relation to early pregnancy loss. Some medical authors advocated change to use of miscarriage instead of spontaneous abortion because they argued this would be more respectful and help ease a distressing experience.[157][158] The change was being recommended by some in the profession in Britain in the late 1990s.[158] In 2005 the European Society for Human Reproduction and Embryology (ESHRE) published a paper aiming to facilitate a revision of nomenclature used to describe early pregnancy events.[102]

Society and culture

Society's reactions to miscarriage have changed over time.[136] In the early 20th century, the focus was on the mother's physical health and the difficulties and disabilities that miscarriage could produce.[136] Other reactions, such as the expense of medical treatments and relief at ending an unwanted pregnancy, were also heard.[136] In the 1940s and 1950s, people were more likely to express relief, not because the miscarriage ended an unwanted or mistimed pregnancy, but because people believed that miscarriages were primarily caused by birth defects, and miscarrying meant that the family would not raise a child with disabilities.[136] The dominant attitude in the mid-century was that a miscarriage, although temporarily distressing, was a blessing in disguise for the family, and that another pregnancy and a healthier baby would soon follow, especially if women trusted physicians and reduced their anxieties.[136] Media articles were illustrated with pictures of babies, and magazine articles about miscarriage ended by introducing the healthy baby—usually a boy—that had shortly followed it.[136]

Beginning in the 1980s, miscarriage in the US was primarily framed in terms of the individual woman's personal emotional reaction, and especially her grief over a tragic outcome.[136] The subject was portrayed in the media with images of an empty crib or an isolated, grieving woman, and stories about miscarriage were published in general-interest media outlets, not just women's magazines or health magazines.[136] Family members were encouraged to grieve, to memorialize their losses through funerals and other rituals, and to think of themselves as being parents.[136] This shift to recognizing these emotional responses was partly due to medical and political successes, which created an expectation that pregnancies are typically planned and safe, and to women's demands that their emotional reactions no longer be dismissed by the medical establishments.[136] It also reinforces the anti-abortion movement’s belief that human life begins at conception or early in pregnancy, and that motherhood is a desirable life goal.[136] The modern one-size-fits-all model of grief does not fit every woman's experience, and an expectation to perform grief creates unnecessary burdens for some women.[136] The reframing of miscarriage as a private emotional experience brought less awareness of miscarriage and a sense of silence around the subject, especially compared to the public discussion of miscarriage during campaigns for access to birth control during the early 20th century, or the public campaigns to prevent miscarriages, stillbirths, and infant deaths by reducing industrial pollution during the 1970s.[136][159]

In places where induced abortion is illegal or carries social stigma, suspicion may surround miscarriage, complicating an already sensitive issue.

In the 1960s, the use of the word miscarriage in Britain (instead of spontaneous abortion) occurred after changes in legislation.

Developments in ultrasound technology (in the early 1980s) allowed them to identify earlier miscarriages.[155]

According to French statutes, an infant born before the age of viability, determined to be 28 weeks, is not registered as a 'child'. If birth occurs after this, the infant is granted a certificate that allows women who have given birth to a stillborn child, to have a symbolic record of that child. This certificate can include a registered and given name to allow a funeral and acknowledgement of the event.[160][161][162]

Other animals

Miscarriage occurs in all animals that experience pregnancy, though in such contexts it is more commonly referred to as a spontaneous abortion (the two terms are synonymous). There are a variety of known risk factors in non-human animals. For example, in sheep, miscarriage may be caused by crowding through doors, or being chased by dogs.[163] In cows, spontaneous abortion may be caused by contagious disease, such as brucellosis or Campylobacter, but often can be controlled by vaccination.[164] In many species of sharks and rays, stress induced miscarriage occurs frequently on capture.[165]

Other diseases are also known to make animals susceptible to miscarriage. Spontaneous abortion occurs in pregnant prairie voles when their mate is removed and they are exposed to a new male,[166] an example of the Bruce effect, although this effect is seen less in wild populations than in the laboratory.[167] Female mice who had spontaneous abortions showed a sharp rise in the amount of time spent with unfamiliar males preceding the abortion than those who did not.[168]

See also

Citations

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General and cited references

  • Hoffman, Barbara; J. Whitridge Williams (2012). Williams Gynecology (2nd ed.). New York: McGraw-Hill Medical. ISBN 978-0071716727.

External links

 
Wikiquote has quotations related to Miscarriage.

April 20, 2023
miscarriage, usage, justice, also, known, medical, terms, spontaneous, abortion, pregnancy, loss, death, embryo, fetus, before, able, survive, independently, before, weeks, gestation, defined, eshre, biochemical, loss, once, ultrasound, histological, evidence,. For usage in law see Miscarriage of justice Miscarriage also known in medical terms as a spontaneous abortion and pregnancy loss is the death of an embryo or fetus before it is able to survive independently 1 4 Miscarriage before 6 weeks of gestation is defined by ESHRE as biochemical loss 13 14 Once ultrasound or histological evidence shows that a pregnancy has existed the used term is clinical miscarriage which can be early before 12 weeks and late between 12 21 weeks 13 Fetal death after 20 weeks of gestation is also known as a stillbirth 15 The most common symptom of a miscarriage is vaginal bleeding with or without pain 1 Sadness anxiety and guilt may occur afterwards 3 16 Tissue and clot like material may leave the uterus and pass through and out of the vagina 17 Recurrent miscarriage also referred to medically as Recurrent Spontaneous Abortion or RSA 18 may also be considered a form of infertility 19 MiscarriageOther namesspontaneous abortion early pregnancy lossAn ultrasound showing a gestational sac containing a yolk sac but no embryoSpecialtyObstetrics and Gynaecology Neonatology PediatricsSymptomsVaginal bleeding with or without pain 1 ComplicationsInfection bleeding 2 sadness anxiety guilt 3 Usual onsetBefore 20 weeks of pregnancy 4 CausesChromosomal abnormalities 1 5 uterine abnormalities 6 Risk factorsBeing an older parent previous miscarriage exposure to tobacco smoke obesity diabetes autoimmune diseases drug or alcohol use 7 8 9 Diagnostic methodPhysical examination human chorionic gonadotropin ultrasound 10 Differential diagnosisEctopic pregnancy implantation bleeding 1 PreventionPrenatal care 11 TreatmentExpectant management vacuum aspiration emotional support 8 12 MedicationmisoprostolFrequency10 50 of pregnancies 1 7 Risk factors for miscarriage include being an older parent previous miscarriage exposure to tobacco smoke obesity diabetes thyroid problems and drug or alcohol use 7 8 About 80 of miscarriages occur in the first 12 weeks of pregnancy the first trimester 1 The underlying cause in about half of cases involves chromosomal abnormalities 5 1 Diagnosis of a miscarriage may involve checking to see if the cervix is open or sealed testing blood levels of human chorionic gonadotropin hCG and an ultrasound 10 Other conditions that can produce similar symptoms include an ectopic pregnancy and implantation bleeding 1 Prevention is occasionally possible with good prenatal care 11 Avoiding drugs alcohol infectious diseases and radiation may decrease the risk of miscarriage 11 No specific treatment is usually needed during the first 7 to 14 days 8 12 Most miscarriages will complete without additional interventions 8 Occasionally the medication misoprostol or a procedure such as vacuum aspiration is used to remove the remaining tissue 12 20 Women who have a blood type of rhesus negative Rh negative may require Rho D immune globulin 8 Pain medication may be beneficial 12 Emotional support may help with processing the loss 12 Miscarriage is the most common complication of early pregnancy 21 Among women who know they are pregnant the miscarriage rate is roughly 10 to 20 while rates among all fertilisation is around 30 to 50 1 7 In those under the age of 35 the risk is about 10 while it is about 45 in those over the age of 40 1 Risk begins to increase around the age of 30 7 About 5 of women have two miscarriages in a row 22 Some recommend not using the term abortion in discussions with those experiencing a miscarriage in an effort to decrease distress 23 In Britain the term miscarriage has replaced any use of the term spontaneous abortion in relation to pregnancy loss and in response to complaints of insensitivity towards women who had suffered such loss 24 An additional benefit of this change is reducing confusion among medical laymen who may not realize that the term spontaneous abortion refers to a naturally occurring medical phenomenon and not the intentional termination of pregnancy Contents 1 Signs and symptoms 2 Risk factors 2 1 Trimesters 2 1 1 First trimester 2 1 2 Second and third trimesters 2 2 Age 2 3 Obesity eating disorders and caffeine 2 4 Endocrine disorders 2 5 Food poisoning 2 6 Amniocentesis and chorionic villus sampling 2 7 Surgery 2 8 Medications 2 9 Immunizations 2 10 Treatments for cancer 2 11 Pre existing diseases 2 12 Immune status 2 13 Anatomical defects and trauma 2 14 Smoking 2 15 Morning sickness 2 16 Chemicals and occupational exposure 2 17 Other 3 Diagnosis 3 1 Ultrasound criteria 3 2 Classification 4 Prevention 4 1 Non modifiable risk factors 4 2 Modifiable risk factors 5 Management 5 1 Methods 5 2 Delayed and incomplete miscarriage 5 3 Induced miscarriage 5 4 Sex 5 5 Support 5 6 Miscarriage leave 6 Outcomes 6 1 Psychological and emotional effects 6 2 Subsequent pregnancies 6 3 Later cardiovascular disease 7 Epidemiology 8 Terminology 9 History 10 Society and culture 11 Other animals 12 See also 13 Citations 14 General and cited references 15 External linksSigns and symptoms EditSigns of a miscarriage include vaginal spotting abdominal pain cramping and fluid blood clots and tissue passing from the vagina 25 26 27 Bleeding can be a symptom of miscarriage but many women also have bleeding in early pregnancy and do not miscarry 28 Bleeding during the first half of pregnancy may be referred to as a threatened miscarriage 29 Of those who seek treatment for bleeding during pregnancy about half will miscarry 30 Miscarriage may be detected during an ultrasound exam or through serial human chorionic gonadotropin HCG testing Risk factors EditFurther information List of miscarriage risks Miscarriage may occur for many reasons not all of which can be identified Risk factors are those things that increase the likelihood of having a miscarriage but do not necessarily cause a miscarriage Up to 70 conditions 1 5 31 32 33 34 infections 35 36 37 medical procedures 38 39 40 lifestyle factors 7 8 41 42 43 occupational exposures 11 44 45 chemical exposure 45 and shift work are associated with increased risk for miscarriage 46 Some of these risks include endocrine genetic uterine or hormonal abnormalities reproductive tract infections and tissue rejection caused by an autoimmune disorder 47 Trimesters Edit First trimester Edit Chromosomal abnormalities found in first trimester miscarriages Description Proportion of totalNormal 45 55 Autosomal trisomy 22 32 Monosomy X 45 X 5 20 Triploidy 6 8 Structural abnormality ofthe chromosome 2 Double or triple trisomy 0 7 2 0 48 Translocation Unknown 49 Most clinically apparent miscarriages two thirds to three quarters in various studies occur during the first trimester 1 35 50 51 About 30 to 40 of all fertilized eggs miscarry often before the pregnancy is known 1 The embryo typically dies before the pregnancy is expelled bleeding into the decidua basalis and tissue necrosis causes uterine contractions to expel the pregnancy 51 Early miscarriages can be due to a developmental abnormality of the placenta or other embryonic tissues In some instances an embryo does not form but other tissues do This has been called a blighted ovum 52 53 48 Successful implantation of the zygote into the uterus is most likely eight to ten days after fertilization If the zygote has not implanted by day ten implantation becomes increasingly unlikely in subsequent days 54 A chemical pregnancy is a pregnancy that was detected by testing but ends in miscarriage before or around the time of the next expected period 55 Chromosomal abnormalities are found in more than half of embryos miscarried in the first 13 weeks Half of embryonic miscarriages 25 of all miscarriages have an aneuploidy abnormal number of chromosomes 56 Common chromosome abnormalities found in miscarriages include an autosomal trisomy 22 32 monosomy X 5 20 triploidy 6 8 tetraploidy 2 4 or other structural chromosomal abnormalities 2 51 Genetic problems are more likely to occur with older parents this may account for the higher rates observed in older women 57 Luteal phase progesterone deficiency may or may not be a contributing factor to miscarriage 58 Second and third trimesters Edit Second trimester losses may be due to maternal factors such as uterine malformation growths in the uterus fibroids or cervical problems 35 These conditions also may contribute to premature birth 50 Unlike first trimester miscarriages second trimester miscarriages are less likely to be caused by a genetic abnormality chromosomal aberrations are found in a third of cases 51 Infection during the third trimester can cause a miscarriage 35 Age Edit Further information Advanced maternal age The age of the pregnant woman is a significant risk factor Miscarriage rates increase steadily with age with more substantial increases after age 35 59 In those under the age of 35 the risk is about 10 while it is about 45 in those over the age of 40 1 Risk begins to increase around the age of 30 7 Paternal age is associated with increased risk 60 Obesity eating disorders and caffeine Edit Not only is obesity associated with miscarriage it can result in sub fertility and other adverse pregnancy outcomes Recurrent miscarriage is also related to obesity Women with bulimia nervosa and anorexia nervosa may have a greater risk for miscarriage Nutrient deficiencies have not been found to impact miscarriage rates but hyperemesis gravidarum sometimes precedes a miscarriage 44 Caffeine consumption also has been correlated to miscarriage rates at least at higher levels of intake 35 However such higher rates are statistically significant only in certain circumstances Vitamin supplementation has generally not shown to be effective in preventing miscarriage 61 Chinese traditional medicine has not been found to prevent miscarriage 27 Endocrine disorders Edit Disorders of the thyroid may affect pregnancy outcomes Related to this iodine deficiency is strongly associated with an increased risk of miscarriage 44 The risk of miscarriage is increased in those with poorly controlled insulin dependent diabetes mellitus 44 Women with well controlled diabetes have the same risk of miscarriage as those without diabetes 62 63 Food poisoning Edit Ingesting food that has been contaminated with listeriosis toxoplasmosis and salmonella is associated with an increased risk of miscarriage 35 19 Amniocentesis and chorionic villus sampling Edit Amniocentesis and chorionic villus sampling CVS are procedures conducted to assess the fetus A sample of amniotic fluid is obtained by the insertion of a needle through the abdomen and into the uterus Chorionic villus sampling is a similar procedure with a sample of tissue removed rather than fluid These procedures are not associated with pregnancy loss during the second trimester but they are associated with miscarriages and birth defects in the first trimester 40 Miscarriage caused by invasive prenatal diagnosis chorionic villus sampling CVS and amniocentesis is rare about 1 39 Surgery Edit The effects of surgery on pregnancy are not well known including the effects of bariatric surgery Abdominal and pelvic surgery are not risk factors for miscarriage Ovarian tumours and cysts that are removed have not been found to increase the risk of miscarriage The exception to this is the removal of the corpus luteum from the ovary This can cause fluctuations in the hormones necessary to maintain the pregnancy 64 Medications Edit There is no significant association between antidepressant medication exposure and miscarriage 65 The risk of miscarriage is not likely decreased by discontinuing SSRIs prior to pregnancy 66 Some available data suggest that there is a small increased risk of miscarriage for women taking any antidepressant 67 68 though this risk becomes less statistically significant when excluding studies of poor quality 65 69 Medicines that increase the risk of miscarriage include retinoids nonsteroidal anti inflammatory drugs NSAIDs such as ibuprofen misoprostol methotrexate 35 statins 70 Immunizations Edit Immunizations have not been found to cause miscarriage 71 Live vaccinations like the MMR vaccine can theoretically cause damage to the fetus as the live virus can cross the placenta and potentially increase the risk for miscarriage 72 73 Therefore the Center for Disease Control CDC recommends against pregnant women receiving live vaccinations 74 However there is no clear evidence that has shown live vaccinations to increase the risk for miscarriage or fetal abnormalities 73 Some live vaccinations include MMR varicella certain types of the influenza vaccine and rotavirus 75 76 Treatments for cancer Edit Ionizing radiation levels given to a woman during cancer treatment cause miscarriage Exposure can also impact fertility The use of chemotherapeutic drugs used to treat childhood cancer increases the risk of future miscarriage 44 Pre existing diseases Edit Several pre existing diseases in pregnancy can potentially increase the risk of miscarriage including diabetes polycystic ovary syndrome PCOS hypothyroidism certain infectious diseases and autoimmune diseases PCOS may increase the risk of miscarriage 35 Two studies suggested treatment with the drug metformin significantly lowers the rate of miscarriage in women with PCOS 77 78 but the quality of these studies has been questioned 79 Metformin treatment in pregnancy has not been shown to be safe 80 In 2007 the Royal College of Obstetricians and Gynaecologists also recommended against use of the drug to prevent miscarriage 79 Thrombophilias or defects in coagulation and bleeding were once thought to be a risk in miscarriage but have been subsequently questioned 81 Severe cases of hypothyroidism increase the risk of miscarriage The effect of milder cases of hypothyroidism on miscarriage rates has not been established A condition called luteal phase defect LPD is a failure of the uterine lining to be fully prepared for pregnancy This can keep a fertilized egg from implanting or result in miscarriage 82 Mycoplasma genitalium infection is associated with increased risk of preterm birth and miscarriage 37 Infections can increase the risk of a miscarriage rubella German measles cytomegalovirus bacterial vaginosis HIV chlamydia gonorrhoea syphilis and malaria 35 Immune status Edit Autoimmunity is a possible cause of recurrent or late term miscarriages In the case of an autoimmune induced miscarriage the woman s body attacks the growing fetus or prevents normal pregnancy progression 9 83 Autoimmune disease may cause abnormalities in embryos which in turn may lead to miscarriage As an example Celiac disease increases the risk of miscarriage by an odds ratio of approximately 1 4 33 34 A disruption in normal immune function can lead to the formation of antiphospholipid antibody syndrome This will affect the ability to continue the pregnancy and if a woman has repeated miscarriages she can be tested for it 45 Approximately 15 of recurrent miscarriages are related to immunologic factors 84 The presence of anti thyroid autoantibodies is associated with an increased risk with an odds ratio of 3 73 and 95 confidence interval 1 8 7 6 85 Having lupus also increases the risk for miscarriage 86 Immunohistochemical studies on decidual basalis and chorionic villi found that the imbalance of the immunological environment could be associated with recurrent pregnancy loss 87 Anatomical defects and trauma Edit Fifteen per cent of women who have experienced three or more recurring miscarriages have some anatomical defect that prevents the pregnancy from being carried for the entire term 88 The structure of the uterus affects the ability to carry a child to term Anatomical differences are common and can be congenital citation needed Type of uterinestructure Miscarriage rateassociated with defect ReferencesBicornate uterus 40 79 31 32 Septate or unicornate 34 88 31 Arcuate Unknown 31 Didelphys 40 31 Fibroids Unknown 35 In some women cervical incompetence or cervical insufficiency occurs with the inability of the cervix to stay closed during the entire pregnancy 36 42 It does not cause first trimester miscarriages In the second trimester it is associated with an increased risk of miscarriage It is identified after a premature birth has occurred at about 16 18 weeks into the pregnancy 88 During the second trimester major trauma can result in a miscarriage 34 Smoking Edit See also Smoking and pregnancy Tobacco cigarette smokers have an increased risk of miscarriage 41 42 There is an increased risk regardless of which parent smokes though the risk is higher when the gestational mother smokes 43 Morning sickness Edit Nausea and vomiting of pregnancy NVP or morning sickness is associated with a decreased risk Several possible causes have been suggested for morning sickness but there is still no agreement 89 NVP may represent a defense mechanism which discourages the mother s ingestion of foods that are harmful to the fetus according to this model a lower frequency of miscarriage would be an expected consequence of the different food choices made by women experiencing NVP 90 Chemicals and occupational exposure Edit Chemical and occupational exposures may have some effect in pregnancy outcomes 91 A cause and effect relationship almost can never be established Those chemicals that are implicated in increasing the risk for miscarriage are DDT lead 92 formaldehyde arsenic benzene and ethylene oxide Video display terminals and ultrasound have not been found to have an effect on the rates of miscarriage In dental offices where nitrous oxide is used with the absence of anesthetic gas scavenging equipment there is a greater risk of miscarriage For women who work with cytotoxic antineoplastic chemotherapeutic agents there is a small increased risk of miscarriage No increased risk for cosmetologists has been found 45 Other Edit Alcohol increases the risk of miscarriage 35 Cocaine use increases the rate of miscarriage 41 Some infections have been associated with miscarriage These include Ureaplasma urealyticum Mycoplasma hominis group B streptococci HIV 1 and syphilis Infections of Chlamydia trachomatis Camphylobacter fetus and Toxoplasma gondii have not been found to be linked to miscarriage 51 Subclinical infections of the lining of the womb commonly known as chronic endometritis are also associated with poor pregnancy outcomes compared to women with treated chronic endometritis or no chronic endometritis 93 Diagnosis EditIn the case of blood loss pain or both transvaginal ultrasound is performed If a viable intrauterine pregnancy is not found with ultrasound blood tests serial bHCG tests can be performed to rule out ectopic pregnancy which is a life threatening situation 94 95 If hypotension tachycardia and anemia are discovered exclusion of an ectopic pregnancy is important 95 A miscarriage may be confirmed by an obstetric ultrasound and by the examination of the passed tissue When looking for microscopic pathologic symptoms one looks for the products of conception Microscopically these include villi trophoblast fetal parts and background gestational changes in the endometrium When chromosomal abnormalities are found in more than one miscarriage genetic testing of both parents may be done 96 Ultrasound criteria Edit A review article in The New England Journal of Medicine based on a consensus meeting of the Society of Radiologists in Ultrasound in America SRU has suggested that miscarriage should be diagnosed only if any of the following criteria are met upon ultrasonography visualization 97 Miscarriage diagnosed Miscarriage suspected ReferencesCrown rump length of at least 7 mm and no heartbeat Crown rump length of less than 7 mm and no heartbeat 97 98 Mean gestational sac diameter of at least 25 mm and no embryo Mean gestational sac diameter of 16 24 mm and no embryo 97 98 Absence of embryo with heartbeat at least 2 weeks after an ultrasound scan that showed a gestational sac without a yolk sac Absence of embryo with heartbeat 7 13 days after an ultrasound scan that showed a gestational sac without a yolk sac 97 98 Absence of embryo with heartbeat at least 11 days after an ultrasound scan that showed a gestational sac with a yolk sac Absence of embryo with heartbeat 7 10 days after a scan that showed a gestational sac with a yolk sac 97 98 Absence of embryo at least 6 weeks after last menstrual period 97 98 Amniotic sac seen adjacent to yolk sac and with no visible embryo 97 98 Yolk sac of more than 7 mm 97 98 Small gestational sac compared to embryo size less than 5 mm difference between mean sac diameter and crown rump length 97 98 Classification Edit A threatened miscarriage is any bleeding during the first half of pregnancy 29 At investigation it may be found that the fetus remains viable and the pregnancy continues without further problems medical citation needed An anembryonic pregnancy also called an empty sac or blighted ovum is a condition where the gestational sac develops normally while the embryonic part of the pregnancy is either absent or stops growing very early This accounts for approximately half of miscarriages All other miscarriages are classified as embryonic miscarriages meaning that there is an embryo present in the gestational sac Half of embryonic miscarriages have aneuploidy an abnormal number of chromosomes 51 An inevitable miscarriage occurs when the cervix has already dilated 99 but the fetus has yet to be expelled This usually will progress to a complete miscarriage The fetus may or may not have cardiac activity Transvaginal ultrasonography after an episode of heavy bleeding in an intrauterine pregnancy that had been confirmed by previous ultrasonography There is some widening between the uterine walls but no sign of any gestational sac thus in this case being diagnostic of a complete miscarriage A complete miscarriage is when all products of conception have been expelled these may include the trophoblast chorionic villi gestational sac yolk sac and fetal pole embryo or later in pregnancy the fetus umbilical cord placenta amniotic fluid and amniotic membrane The presence of a pregnancy test that is still positive as well as an empty uterus upon transvaginal ultrasonography does however fulfil the definition of pregnancy of unknown location Therefore there may be a need for follow up pregnancy tests to ensure that there is no remaining pregnancy including ectopic pregnancy citation needed Transvaginal ultrasonography with some products of conception in the cervix to the left in the image and remnants of a gestational sac by the fundus to the right in the image indicating an incomplete miscarriage An incomplete miscarriage occurs when some products of conception have been passed but some remains inside the uterus 100 However an increased distance between the uterine walls on transvaginal ultrasonography may also simply be an increased endometrial thickness and or a polyp The use of a Doppler ultrasound may be better in confirming the presence of significant retained products of conception in the uterine cavity 101 In cases of uncertainty ectopic pregnancy must be excluded using techniques like serial beta hCG measurements 101 A 13 week fetus without cardiac activity located in the uterus delayed or missed miscarriage A missed miscarriage is when the embryo or fetus has died but a miscarriage has not yet occurred It is also referred to as delayed miscarriage silent miscarriage or missed abortion 102 103 A septic miscarriage occurs when the tissue from a missed or incomplete miscarriage becomes infected which carries the risk of spreading infection septicaemia and can be fatal 51 Recurrent miscarriage recurrent pregnancy loss RPL recurrent spontaneous abortion RSA or habitual abortion is the occurrence of multiple consecutive miscarriages the exact number used to diagnose recurrent miscarriage varies however two is the minimum threshold to meet the criteria 104 51 105 If the proportion of pregnancies ending in miscarriage is 15 and assuming that miscarriages are independent events 106 then the probability of two consecutive miscarriages is 2 25 and the probability of three consecutive miscarriages is 0 34 The occurrence of recurrent pregnancy loss is 1 106 A large majority 85 of those who have had two miscarriages will conceive and carry normally afterward 106 The physical symptoms of a miscarriage vary according to the length of pregnancy though most miscarriages cause pain or cramping The size of blood clots and pregnancy tissue that are passed become larger with longer gestations After 13 weeks gestation there is a higher risk of placenta retention 107 Prevention EditPrevention of a miscarriage can sometimes be accomplished by decreasing risk factors 11 This may include good prenatal care avoiding drugs and alcohol preventing infectious diseases and avoiding x rays 11 Identifying the cause of the miscarriage may help prevent future pregnancy loss especially in cases of recurrent miscarriage Often there is little a person can do to prevent a miscarriage 11 Vitamin supplementation before or during pregnancy has not been found to affect the risk of miscarriage 108 Progesterone has been shown to prevent miscarriage in women with 1 vaginal bleeding early in their current pregnancy and 2 a previous history of miscarriage 109 Non modifiable risk factors Edit Preventing a miscarriage in subsequent pregnancies may be enhanced with assessments of Immune status 9 83 Chemical and occupational exposures 45 Anatomical defects 88 32 Pre existing or acquired disease in pregnancy 81 37 Polycystic ovary syndrome 110 77 78 80 79 Previous exposure to chemotherapy and radiation Medications 34 65 66 67 68 69 Surgical history 64 Endocrine disorders 44 111 needs update Genetic abnormalities 31 32 Modifiable risk factors Edit Maintaining a healthy weight and good prenatal care can reduce the risk of miscarriage 35 Some risk factors can be minimized by avoiding the following Smoking 41 43 35 Cocaine use 41 Alcohol 35 Poor nutrition Occupational exposure to agents that can cause miscarriage 45 Medications associated with miscarriage 71 66 35 Drug abuse 35 Management EditWomen who miscarry early in their pregnancy usually do not require any subsequent medical treatment but they can benefit from support and counseling 28 112 Most early miscarriages will complete on their own in other cases medication treatment or aspiration of the products of conception can be used to remove remaining tissue 113 While bed rest has been advocated to prevent miscarriage this has not been found to be of benefit 114 26 Those who are experiencing or who have experienced a miscarriage benefit from the use of careful medical language Significant distress can often be managed by the ability of the clinician to clearly explain terms without suggesting that the woman or couple are somehow to blame 115 Evidence to support Rho D immune globulin after a spontaneous miscarriage is unclear 116 In the UK Rho D immune globulin is recommended in Rh negative women after 12 weeks gestational age and before 12 weeks gestational age in those who need surgery or medication to complete the miscarriage 117 Methods Edit No treatment is necessary for a diagnosis of complete miscarriage so long as ectopic pregnancy is ruled out In cases of an incomplete miscarriage empty sac or missed abortion there are three treatment options watchful waiting medical management and surgical treatment With no treatment watchful waiting most miscarriages 65 80 will pass naturally within two to six weeks 118 This treatment avoids the possible side effects and complications of medications and surgery 119 but increases the risk of mild bleeding need for unplanned surgical treatment and incomplete miscarriage Medical treatment usually consists of using misoprostol a prostaglandin alone or in combination with mifepristone pre treatment 120 These medications help the uterus to contract and expel the remaining tissue out of the body This works within a few days in 95 of cases 118 Vacuum aspiration or sharp curettage can be used with vacuum aspiration being lower risk and more common 118 Delayed and incomplete miscarriage Edit In delayed or incomplete miscarriage treatment depends on the amount of tissue remaining in the uterus Treatment can include surgical removal of the tissue with vacuum aspiration or misoprostol 121 Studies looking at the methods of anaesthesia for surgical management of incomplete miscarriage have not shown that any adaptation from normal practice is beneficial 122 Induced miscarriage Edit Further information Self induced abortion An induced abortion may be performed by a qualified healthcare provider for women who cannot continue the pregnancy 123 Self induced abortion performed by a woman or non medical personnel can be dangerous and is still a cause of maternal mortality in some countries In some locales it is illegal or carries heavy social stigma 124 Sex Edit Some organizations recommend delaying sex after a miscarriage until the bleeding has stopped to decrease the risk of infection 125 However there is not sufficient evidence for the routine use of antibiotic to try to avoid infection in incomplete abortion 126 Others recommend delaying attempts at pregnancy until one period has occurred to make it easier to determine the dates of a subsequent pregnancy 125 There is no evidence that getting pregnant in that first cycle affects outcomes and an early subsequent pregnancy may actually improve outcomes 125 127 Support Edit Organizations exist that provide information and counselling to help those who have had a miscarriage 128 Family and friends often conduct a memorial or burial service Hospitals also can provide support and help memorialize the event Depending on locale others desire to have a private ceremony 128 Providing appropriate support with frequent discussions and sympathetic counselling are part of evaluation and treatment Those who experience unexplained miscarriage can be treated with emotional support 112 115 Miscarriage leave Edit Miscarriage leave is leave of absence in relation to miscarriage The following countries offer paid or unpaid leave to women who have had a miscarriage The Philippines 60 days fully paid leave for miscarriages before 20 weeks of gestation or emergency termination of the pregnancy on the 20th week or after 129 The husband of the mother gets seven days fully paid leave up to the 4th pregnancy 130 India six weeks leave 131 New Zealand three days bereavement leave for both parents 132 Mauritius two weeks leave 133 Indonesia six weeks leave 134 Taiwan five days one week or four weeks depending on how advanced the pregnancy was 135 Outcomes EditPsychological and emotional effects Edit A cemetery for miscarried fetuses stillborn babies and babies who have died soon after birth See also Miscarriage and grief and Miscarriage and mental illness Every woman s personal experience of miscarriage is different and women who have more than one miscarriage may react differently to each event 136 In Western cultures since the 1980s 136 medical providers assume that experiencing a miscarriage is a major loss for all pregnant women 112 A miscarriage can result in anxiety depression or stress for those involved 95 137 138 It can have an effect on the whole family 139 Many of those experiencing a miscarriage go through a grieving process 3 140 141 Prenatal attachment often exists that can be seen as parental sensitivity love and preoccupation directed toward the unborn child 142 Serious emotional impact is usually experienced immediately after the miscarriage 3 Some may go through the same loss when an ectopic pregnancy is terminated 35 In some the realization of the loss can take weeks Providing family support to those experiencing the loss can be challenging because some find comfort in talking about the miscarriage while others may find the event painful to discuss The father can have the same sense of loss Expressing feelings of grief and loss can sometimes be harder for men Some women are able to begin planning their next pregnancy after a few weeks of having the miscarriage For others planning another pregnancy can be difficult 128 125 Some facilities acknowledge the loss Parents can name and hold their infant They may be given mementos such as photos and footprints Some conduct a funeral or memorial service They may express the loss by planting a tree 143 Some health organizations recommend that sexual activity be delayed after the miscarriage The menstrual cycle should resume after about three to four months 128 Women report that they were dissatisfied with the care they received from physicians and nurses 144 needs context Subsequent pregnancies Edit Some parents want to try to have a baby very soon after the miscarriage The decision of trying to become pregnant again can be difficult Reasons exist that may prompt parents to consider another pregnancy For older mothers there may be some sense of urgency Other parents are optimistic that future pregnancies are likely to be successful Many are hesitant and want to know about the risk of having another or more miscarriages Some clinicians recommend that the women have one menstrual cycle before attempting another pregnancy This is because the date of conception may be hard to determine Also the first menstrual cycle after a miscarriage can be much longer or shorter than expected Parents may be advised to wait even longer if they have experienced late miscarriage or molar pregnancy or are undergoing tests Some parents wait for six months based upon recommendations from their health care provider 125 Research shows that depression after a miscarriage or stillbirth can continue for years even after the birth of a subsequent child Medical professionals are advised to take previous loss of a pregnancy into account when assessing risks for postnatal depression following the birth of a subsequent infant It is believed that supportive interventions may improve the health outcomes of both the mother and the child 145 The risks of having another miscarriage vary according to the cause The risk of having another miscarriage after a molar pregnancy is very low The risk of another miscarriage is highest after the third miscarriage Pre conception care is available in some locales 125 Later cardiovascular disease Edit There is a significant association between miscarriage and later development of coronary artery disease but not of cerebrovascular disease 146 34 Epidemiology EditAmong women who know they are pregnant the miscarriage rate is roughly 10 to 20 while rates among all fertilized zygotes are around 30 to 50 1 7 51 112 A 2012 review found the risk of miscarriage between 5 and 20 weeks from 11 to 22 147 Up to the 13th week of pregnancy the risk of miscarriage each week was around 2 dropping to 1 in week 14 and reducing slowly between 14 and 20 weeks 147 The precise rate is not known because a large number of miscarriages occur before pregnancies become established and before the woman is aware she is pregnant 147 Additionally those with bleeding in early pregnancy may seek medical care more often than those not experiencing bleeding 147 Although some studies attempt to account for this by recruiting women who are planning pregnancies and testing for very early pregnancy they still are not representative of the wider population 147 The prevalence of miscarriage increases with the age of both parents 147 148 149 In a Danish register based study where the prevalence of miscarriage was 11 the prevalence rose from 9 at 22 years of age to 84 by 48 years of age 150 needs update Another later study in 2013 found that when either parent was over the age of 40 the rate of known miscarriages doubled 51 In 2010 50 000 inpatient admissions for miscarriage occurred in the UK 16 Terminology EditMost affected women and family members refer to miscarriage as the loss of a baby rather than an embryo or fetus and healthcare providers are expected to respect and use the language that the person chooses 115 Clinical terms can suggest blame increase distress and even cause anger Terms that are known to cause distress in those experiencing miscarriage include abortion including spontaneous abortion rather than miscarriage habitual aborter rather than a woman experiencing recurrent pregnancy loss products of conception rather than baby blighted ovum rather than early pregnancy loss or delayed miscarriage cervical incompetence rather than cervical weakness and evacuation of retained products of conception ERPC rather than surgical management of miscarriage 115 Pregnancy loss is a broad term that is used for miscarriage ectopic and molar pregnancies 115 The term fetal death applies variably in different countries and contexts sometimes incorporating weight and gestational age from 16 weeks in Norway 20 weeks in the US and Australia 24 weeks in the UK to 26 weeks in Italy and Spain 151 152 153 A fetus that died before birth after this gestational age may be referred to as a stillbirth 151 Under UK law all stillbirths should be registered 154 although this does not apply to miscarriages History EditThe medical terminology applied to experiences during early pregnancy has changed over time 155 Before the 1980s health professionals used the phrase spontaneous abortion for a miscarriage and induced abortion for a termination of the pregnancy 155 156 In the late 1980s and 1990s doctors became more conscious of their language in relation to early pregnancy loss Some medical authors advocated change to use of miscarriage instead of spontaneous abortion because they argued this would be more respectful and help ease a distressing experience 157 158 The change was being recommended by some in the profession in Britain in the late 1990s 158 In 2005 the European Society for Human Reproduction and Embryology ESHRE published a paper aiming to facilitate a revision of nomenclature used to describe early pregnancy events 102 Society and culture EditSociety s reactions to miscarriage have changed over time 136 In the early 20th century the focus was on the mother s physical health and the difficulties and disabilities that miscarriage could produce 136 Other reactions such as the expense of medical treatments and relief at ending an unwanted pregnancy were also heard 136 In the 1940s and 1950s people were more likely to express relief not because the miscarriage ended an unwanted or mistimed pregnancy but because people believed that miscarriages were primarily caused by birth defects and miscarrying meant that the family would not raise a child with disabilities 136 The dominant attitude in the mid century was that a miscarriage although temporarily distressing was a blessing in disguise for the family and that another pregnancy and a healthier baby would soon follow especially if women trusted physicians and reduced their anxieties 136 Media articles were illustrated with pictures of babies and magazine articles about miscarriage ended by introducing the healthy baby usually a boy that had shortly followed it 136 Beginning in the 1980s miscarriage in the US was primarily framed in terms of the individual woman s personal emotional reaction and especially her grief over a tragic outcome 136 The subject was portrayed in the media with images of an empty crib or an isolated grieving woman and stories about miscarriage were published in general interest media outlets not just women s magazines or health magazines 136 Family members were encouraged to grieve to memorialize their losses through funerals and other rituals and to think of themselves as being parents 136 This shift to recognizing these emotional responses was partly due to medical and political successes which created an expectation that pregnancies are typically planned and safe and to women s demands that their emotional reactions no longer be dismissed by the medical establishments 136 It also reinforces the anti abortion movement s belief that human life begins at conception or early in pregnancy and that motherhood is a desirable life goal 136 The modern one size fits all model of grief does not fit every woman s experience and an expectation to perform grief creates unnecessary burdens for some women 136 The reframing of miscarriage as a private emotional experience brought less awareness of miscarriage and a sense of silence around the subject especially compared to the public discussion of miscarriage during campaigns for access to birth control during the early 20th century or the public campaigns to prevent miscarriages stillbirths and infant deaths by reducing industrial pollution during the 1970s 136 159 In places where induced abortion is illegal or carries social stigma suspicion may surround miscarriage complicating an already sensitive issue In the 1960s the use of the word miscarriage in Britain instead of spontaneous abortion occurred after changes in legislation Developments in ultrasound technology in the early 1980s allowed them to identify earlier miscarriages 155 According to French statutes an infant born before the age of viability determined to be 28 weeks is not registered as a child If birth occurs after this the infant is granted a certificate that allows women who have given birth to a stillborn child to have a symbolic record of that child This certificate can include a registered and given name to allow a funeral and acknowledgement of the event 160 161 162 Other animals EditMiscarriage occurs in all animals that experience pregnancy though in such contexts it is more commonly referred to as a spontaneous abortion the two terms are synonymous There are a variety of known risk factors in non human animals For example in sheep miscarriage may be caused by crowding through doors or being chased by dogs 163 In cows spontaneous abortion may be caused by contagious disease such as brucellosis or Campylobacter but often can be controlled by vaccination 164 In many species of sharks and rays stress induced miscarriage occurs frequently on capture 165 Other diseases are also known to make animals susceptible to miscarriage Spontaneous abortion occurs in pregnant prairie voles when their mate is removed and they are exposed to a new male 166 an example of the Bruce effect although this effect is seen less in wild populations than in the laboratory 167 Female mice who had spontaneous abortions showed a sharp rise in the amount of time spent with unfamiliar males preceding the abortion than those who did not 168 See also EditPregnancy and Infant Loss Remembrance Day Perinatal bereavement Reproductive lossCitations Edit a b c d e f g h i j k l m n o p The Johns Hopkins Manual of Gynecology and Obstetrics 4 ed Lippincott Williams amp Wilkins 2012 pp 438 439 ISBN 978 1451148015 Archived from the 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JL May 2009 Female behaviour plays a critical role in controlling murine pregnancy block Proceedings Biological Sciences 276 1662 1723 9 doi 10 1098 rspb 2008 1780 JSTOR 30245000 PMC 2660991 PMID 19324836 General and cited references EditHoffman Barbara J Whitridge Williams 2012 Williams Gynecology 2nd ed New York McGraw Hill Medical ISBN 978 0071716727 External links Edit Wikiquote has quotations related to Miscarriage Retrieved from https en wikipedia org w index php title Miscarriage amp oldid 1150722400, wikipedia, wiki, book, books, library,

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