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Wikipedia

GNA12

April 13, 2024

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[5][6][7]

GNA12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGNA12, NNX3, RMP, gep, G protein subunit alpha 12, HG1M1
External IDsOMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12
Orthologs
SpeciesHumanMouse
Entrez

2768

14673

Ensembl

ENSG00000146535

ENSMUSG00000000149

UniProt

Q03113

P27600

RefSeq (mRNA)

NM_001282440
NM_001282441
NM_001293092
NM_007353

NM_010302

RefSeq (protein)

NP_001269369
NP_001269370
NP_001280021
NP_031379

NP_034432

Location (UCSC)Chr 7: 2.73 – 2.84 MbChr 5: 140.74 – 140.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions and functions edit

The GNA12 gene encodes the G12 G protein alpha subunit. Together with GNA13, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits.[8] Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein-coupled receptors to intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP.[9][10]

Active GTP-bound G12 alpha subunit interacts with and activates ARHGEF1,[11] ARHGEF11,[12][13] and ARHGEF12.[14][15] These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton.[16]

GNA12 also interacts with PPP5C,[17] HSP90,[18] Resistance to inhibitors of cholinesterase-8A (Ric-8A)[19] and TEC.[15]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146535 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000149 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.
  6. ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
  7. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
  8. ^ Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. Bibcode:1991PNAS...88.5582S. doi:10.1073/pnas.88.13.5582. PMC 51921. PMID 1905812.
  9. ^ Gilman, AG (1987). "G proteins: transducers of receptor-generated signals". Annual Review of Biochemistry. 56: 615–649. doi:10.1146/annurev.bi.56.070187.003151. PMID 3113327.
  10. ^ Rodbell, M (1995). "Nobel Lecture: Signal transduction: Evolution of an idea". Bioscience Reports. 15 (3): 117–133. doi:10.1007/bf01207453. PMC 1519115. PMID 7579038. S2CID 11025853.
  11. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. S2CID 6798899.
  12. ^ Fukuhara, S; Murga, C; Zohar, M; Igishi, T; Gutkind, JS (1999-02-26). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". Journal of Biological Chemistry. 274 (9): 5868–5879. doi:10.1074/jbc.274.9.5868. PMID 10026210.
  13. ^ Rümenapp, U; Blomquist, A; Schwörer, G; Schablowski, H; Psoma, A; Jakobs, KH (1999-10-15). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Letters. 459 (3): 313–318. doi:10.1016/s0014-5793(99)01270-3. PMID 10526156. S2CID 8529412.
  14. ^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. S2CID 7300556.
  15. ^ a b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. Bibcode:2003PNAS..100..733S. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  16. ^ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523.
  17. ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
  18. ^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.
  19. ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.

External links edit

  • GNA12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: P27600 (Mouse Guanine nucleotide-binding protein subunit alpha-12 (GNA12)) at the PDBe-KB.


 

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

April 13, 2024
gna12, guanine, nucleotide, binding, protein, subunit, alpha, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1zcaidentifiersaliases, nnx3, protein, subunit, alpha, hg1m1external, idsomim, 604394, 95767, hom. Guanine nucleotide binding protein subunit alpha 12 is a protein that in humans is encoded by the GNA12 gene 5 6 7 GNA12Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1ZCAIdentifiersAliasesGNA12 NNX3 RMP gep G protein subunit alpha 12 HG1M1External IDsOMIM 604394 MGI 95767 HomoloGene 22398 GeneCards GNA12Gene location Human Chr Chromosome 7 human 1 Band7p22 3 p22 2Start2 728 105 bp 1 End2 844 308 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 79 3 cMStart140 744 163 bp 2 End140 816 186 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytestromal cell of endometriuminternal globus pallidusamygdalanucleus accumbensputamencaudate nucleussubstantia nigraright coronary arterysaphenous veinTop expressed inmyocardium of ventricleinterventricular septummolarright ventricleproximal tubulesecondary oocyteexternal carotid arteryyolk sacrenal corpuscleadrenal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding GTP binding metal ion binding protein binding guanyl nucleotide binding G protein coupled receptor binding D5 dopamine receptor binding signal transducer activity G protein beta gamma subunit complex binding GTPase activityCellular componentmembrane focal adhesion heterotrimeric G protein complex brush border membrane cytoplasm plasma membrane lateral plasma membraneBiological processcell differentiation intracellular signal transduction regulation of TOR signaling adenylate cyclase modulating G protein coupled receptor signaling pathway small GTPase mediated signal transduction embryonic digit morphogenesis blood coagulation in utero embryonic development platelet activation regulation of cell shape regulation of proteasomal ubiquitin dependent protein catabolic process signal transduction G protein coupled receptor signaling pathway regulation of fibroblast migration Rho protein signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez276814673EnsemblENSG00000146535ENSMUSG00000000149UniProtQ03113P27600RefSeq mRNA NM 001282440NM 001282441NM 001293092NM 007353NM 010302RefSeq protein NP 001269369NP 001269370NP 001280021NP 031379NP 034432Location UCSC Chr 7 2 73 2 84 MbChr 5 140 74 140 82 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions and functions 2 See also 3 References 4 External linksInteractions and functions editThe GNA12 gene encodes the G12 G protein alpha subunit Together with GNA13 these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits 8 Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein coupled receptors to intracellular signaling pathways to modulate cell functions G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle and are active when bound to GTP but inactive and associated with the G beta gamma complex when bound to GDP 9 10 Active GTP bound G12 alpha subunit interacts with and activates ARHGEF1 11 ARHGEF11 12 13 and ARHGEF12 14 15 These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton 16 GNA12 also interacts with PPP5C 17 HSP90 18 Resistance to inhibitors of cholinesterase 8A Ric 8A 19 and TEC 15 See also editG12 G13 alpha subunits G protein coupled receptor Heterotrimeric G protein Rho family of GTPasesReferences edit a b c GRCh38 Ensembl release 89 ENSG00000146535 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000000149 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chan AM Fleming TP McGovern ES Chedid M Miki T Aaronson SA February 1993 Expression cDNA cloning of a transforming gene encoding the wild type G alpha 12 gene product Molecular and Cellular Biology 13 2 762 8 doi 10 1128 mcb 13 2 762 PMC 358958 PMID 8423800 Kumar RN Shore SK Dhanasekaran N February 2006 Neoplastic transformation by the gep oncogene Galpha12 involves signaling by STAT3 Oncogene 25 6 899 906 doi 10 1038 sj onc 1209132 PMID 16247467 Entrez Gene GNA12 guanine nucleotide binding protein G protein alpha 12 Strathmann MP Simon MI 1991 G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits Proc Natl Acad Sci U S A 88 13 5582 6 Bibcode 1991PNAS 88 5582S doi 10 1073 pnas 88 13 5582 PMC 51921 PMID 1905812 Gilman AG 1987 G proteins transducers of receptor generated signals Annual Review of Biochemistry 56 615 649 doi 10 1146 annurev bi 56 070187 003151 PMID 3113327 Rodbell M 1995 Nobel Lecture Signal transduction Evolution of an idea Bioscience Reports 15 3 117 133 doi 10 1007 bf01207453 PMC 1519115 PMID 7579038 S2CID 11025853 Johnson EN Seasholtz TM Waheed AA Kreutz B Suzuki N Kozasa T Jones TL Brown JH Druey KM December 2003 RGS16 inhibits signalling through the G alpha 13 Rho axis Nature Cell Biology 5 12 1095 103 doi 10 1038 ncb1065 PMID 14634662 S2CID 6798899 Fukuhara S Murga C Zohar M Igishi T Gutkind JS 1999 02 26 A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho Journal of Biological Chemistry 274 9 5868 5879 doi 10 1074 jbc 274 9 5868 PMID 10026210 Rumenapp U Blomquist A Schworer G Schablowski H Psoma A Jakobs KH 1999 10 15 Rho specific binding and guanine nucleotide exchange catalysis by KIAA0380 a dbl family member FEBS Letters 459 3 313 318 doi 10 1016 s0014 5793 99 01270 3 PMID 10526156 S2CID 8529412 Fukuhara S Chikumi H Gutkind JS November 2000 Leukemia associated Rho guanine nucleotide exchange factor LARG links heterotrimeric G proteins of the G 12 family to Rho FEBS Letters 485 2 3 183 8 doi 10 1016 S0014 5793 00 02224 9 PMID 11094164 S2CID 7300556 a b Suzuki N Nakamura S Mano H Kozasa T January 2003 Galpha 12 activates Rho GTPase through tyrosine phosphorylated leukemia associated RhoGEF Proceedings of the National Academy of Sciences of the United States of America 100 2 733 8 Bibcode 2003PNAS 100 733S doi 10 1073 pnas 0234057100 PMC 141065 PMID 12515866 Dhanasekaran N Dermott JM 1996 Signaling by the G12 class of G proteins Cell Signal 8 4 235 45 doi 10 1016 0898 6568 96 00048 4 PMID 8842523 Yamaguchi Y Katoh H Mori K Negishi M August 2002 Galpha 12 and Galpha 13 interact with Ser Thr protein phosphatase type 5 and stimulate its phosphatase activity Current Biology 12 15 1353 8 doi 10 1016 S0960 9822 02 01034 5 PMID 12176367 S2CID 11485795 Vaiskunaite R Kozasa T Voyno Yasenetskaya TA December 2001 Interaction between the G alpha subunit of heterotrimeric G 12 protein and Hsp90 is required for G alpha 12 signaling The Journal of Biological Chemistry 276 49 46088 93 doi 10 1074 jbc M108711200 PMID 11598136 Wang L Guo D Xing B Zhang JJ Shu HB Guo L Huang XY September 2011 Resistance to inhibitors of cholinesterase 8A Ric 8A is critical for growth factor receptor induced actin cytoskeletal reorganization The Journal of Biological Chemistry 286 35 31055 61 doi 10 1074 jbc M111 253427 PMC 3162464 PMID 21771786 External links editGNA12 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Overview of all the structural information available in the PDB for UniProt P27600 Mouse Guanine nucleotide binding protein subunit alpha 12 GNA12 at the PDBe KB nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GNA12 amp oldid 1170050817, wikipedia, wiki, book, books, library,

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