^ abcGRCh38: Ensembl release 89: ENSG00000011485 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000003099 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Sep 1995). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics. 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404.
^"Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit".
^Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC125685. PMID 11689443.
^Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
^Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
^Chatterjee A, Wang L, Armstrong DL, Rossie S (Feb 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". The Journal of Biological Chemistry. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC2823530. PMID 19948726.
Further readingedit
Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PT (Sep 1994). "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus". The EMBO Journal. 13 (18): 4278–90. doi:10.1002/j.1460-2075.1994.tb06748.x. PMC395355. PMID 7925273.
Skinner J, Sinclair C, Romeo C, Armstrong D, Charbonneau H, Rossie S (Sep 1997). "Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5". The Journal of Biological Chemistry. 272 (36): 22464–71. doi:10.1074/jbc.272.36.22464. PMID 9278397.
Shah BH, Catt KJ (Dec 2006). "Protein phosphatase 5 as a negative key regulator of Raf-1 activation". Trends in Endocrinology and Metabolism. 17 (10): 382–4. doi:10.1016/j.tem.2006.10.013. PMID 17084641. S2CID 45060016.
Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters. 312 (1): 95–9. doi:10.1016/0014-5793(92)81418-L. PMID 1330687. S2CID 34940651.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Xu X, Lagercrantz J, Zickert P, Bajalica-Lagercrantz S, Zetterberg A (Jan 1996). "Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene". Biochemical and Biophysical Research Communications. 218 (2): 514–7. doi:10.1006/bbrc.1996.0092. PMID 8561788.
Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (Jun 1997). "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin". The Journal of Biological Chemistry. 272 (26): 16224–30. doi:10.1074/jbc.272.26.16224. PMID 9195923.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
Das AK, Cohen PW, Barford D (Mar 1998). "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions". The EMBO Journal. 17 (5): 1192–9. doi:10.1093/emboj/17.5.1192. PMC1170467. PMID 9482716.
Russell LC, Whitt SR, Chen MS, Chinkers M (Jul 1999). "Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90". The Journal of Biological Chemistry. 274 (29): 20060–3. doi:10.1074/jbc.274.29.20060. PMID 10400612.
Lubert EJ, Hong Y, Sarge KD (Oct 2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". The Journal of Biological Chemistry. 276 (42): 38582–7. doi:10.1074/jbc.M106906200. PMID 11504734.
Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC125685. PMID 11689443.
Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S (Oct 2009). "Protein phosphatase 5 protects neurons against amyloid-beta toxicity". Journal of Neurochemistry. 111 (2): 391–402. doi:10.1111/j.1471-4159.2009.06337.x. PMC3044491. PMID 19686245.
Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL (Mar 2006). "Rac GTPase signaling through the PP5 protein phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 103 (13): 5202–6. Bibcode:2006PNAS..103.5202G. doi:10.1073/pnas.0600080103. PMC1458818. PMID 16549782.
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". Neuroscience. 115 (3): 829–37. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421. S2CID 26118803.
Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE (Mar 2003). "Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression". The Journal of Biological Chemistry. 278 (11): 9747–53. doi:10.1074/jbc.M210993200. PMID 12519780.
Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
January 01, 1970
ppp5c, serine, threonine, protein, phosphatase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1a17, 1s95, 1wao, 2bug, 3h60, 3h61, 3h62, 3h63, 3h64, 3h66, 3h67, 3h68, 3h69, 4zx2, 4zvzidentifiersaliases, ppp5. Serine threonine protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene 5 6 PPP5CAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZX2 4ZVZIdentifiersAliasesPPP5C PP5 PPP5 PPT protein phosphatase 5 catalytic subunitExternal IDsOMIM 600658 MGI 102666 HomoloGene 4550 GeneCards PPP5CGene location Human Chr Chromosome 19 human 1 Band19q13 32Start46 347 087 bp 1 End46 392 981 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 A2 7 9 15 cMStart16 738 565 bp 2 End16 761 849 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubeganglionic eminenceanterior pituitarystromal cell of endometriumright adrenal glandleft adrenal glandgastric mucosaright lobe of thyroid glandbody of stomachtransverse colonTop expressed inyolk sacsuperior frontal gyruscerebellar cortexsomitelipneural tubeprimitive streakstomachright ventriclesubmandibular glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionphosphoprotein phosphatase activity heat shock protein binding microtubule binding ADP binding protein serine threonine phosphatase activity signal transducer activity metal ion binding protein binding RNA binding identical protein binding G protein alpha subunit binding hydrolase activity ATP binding lipid binding Hsp90 protein bindingCellular componentperikaryon membrane intracellular membrane bounded organelle plasma membrane neuronal cell body proximal dendrite neuron projection nucleus cell periphery nucleoplasm cytoplasm cytosolBiological processnegative regulation of protein phosphorylation positive regulation of glucocorticoid receptor signaling pathway protein heterooligomerization protein dephosphorylation negative regulation of cell death cellular response to cadmium ion transcription DNA templated MAPK cascade cellular response to DNA damage stimulus response to morphine response to lead ion protein complex oligomerization positive regulation of I kappaB kinase NF kappaB signaling cellular response to hydrogen peroxide negative regulation of neuron death DNA repair mitotic cell cycleSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez553619060EnsemblENSG00000011485ENSMUSG00000003099UniProtP53041Q60676RefSeq mRNA NM 006247NM 001204284NM 011155RefSeq protein NP 001191213NP 006238NP 035285Location UCSC Chr 19 46 35 46 39 MbChr 7 16 74 16 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editPPP5C has been shown to interact with ASK1 7 CRY2 8 GNA12 9 and Rac1 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000011485 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000003099 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yong WH Ueki K Chou D Reeves SA von Deimling A Gusella JF Mohrenweiser HW Buckler AJ Louis DN Sep 1995 Cloning of a highly conserved human protein serine threonine phosphatase gene from the glioma candidate region on chromosome 19q13 3 Genomics 29 2 533 6 doi 10 1006 geno 1995 9972 PMID 8666404 Entrez Gene PPP5C Protein phosphatase 5 catalytic subunit Morita K Saitoh M Tobiume K Matsuura H Enomoto S Nishitoh H Ichijo H Nov 2001 Negative feedback regulation of ASK1 by protein phosphatase 5 PP5 in response to oxidative stress The EMBO Journal 20 21 6028 36 doi 10 1093 emboj 20 21 6028 PMC 125685 PMID 11689443 Zhao S Sancar A Nov 1997 Human blue light photoreceptor hCRY2 specifically interacts with protein serine threonine phosphatase 5 and modulates its activity Photochemistry and Photobiology 66 5 727 31 doi 10 1111 j 1751 1097 1997 tb03214 x PMID 9383998 S2CID 32804361 Yamaguchi Y Katoh H Mori K Negishi M Aug 2002 Galpha 12 and Galpha 13 interact with Ser Thr protein phosphatase type 5 and stimulate its phosphatase activity Current Biology 12 15 1353 8 doi 10 1016 S0960 9822 02 01034 5 PMID 12176367 S2CID 11485795 Chatterjee A Wang L Armstrong DL Rossie S Feb 2010 Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro The Journal of Biological Chemistry 285 6 3872 82 doi 10 1074 jbc M109 088427 PMC 2823530 PMID 19948726 Further reading editChen MX McPartlin AE Brown L Chen YH Barker HM Cohen PT Sep 1994 A novel human protein serine threonine phosphatase which possesses four tetratricopeptide repeat motifs and localizes to the nucleus The EMBO Journal 13 18 4278 90 doi 10 1002 j 1460 2075 1994 tb06748 x PMC 395355 PMID 7925273 Skinner J Sinclair C Romeo C Armstrong D Charbonneau H Rossie S Sep 1997 Purification of a fatty acid stimulated protein serine threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5 The Journal of Biological Chemistry 272 36 22464 71 doi 10 1074 jbc 272 36 22464 PMID 9278397 Shah BH Catt KJ Dec 2006 Protein phosphatase 5 as a negative key regulator of Raf 1 activation Trends in Endocrinology and Metabolism 17 10 382 4 doi 10 1016 j tem 2006 10 013 PMID 17084641 S2CID 45060016 Goedert M Cohen ES Jakes R Cohen P Nov 1992 p42 MAP kinase phosphorylation sites in microtubule associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer s disease corrected FEBS Letters 312 1 95 9 doi 10 1016 0014 5793 92 81418 L PMID 1330687 S2CID 34940651 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Xu X Lagercrantz J Zickert P Bajalica Lagercrantz S Zetterberg A Jan 1996 Chromosomal localization and 5 sequence of the human protein serine threonine phosphatase 5 gene Biochemical and Biophysical Research Communications 218 2 514 7 doi 10 1006 bbrc 1996 0092 PMID 8561788 Silverstein AM Galigniana MD Chen MS Owens Grillo JK Chinkers M Pratt WB Jun 1997 Protein phosphatase 5 is a major component of glucocorticoid receptor hsp90 complexes with properties of an FK506 binding immunophilin The Journal of Biological Chemistry 272 26 16224 30 doi 10 1074 jbc 272 26 16224 PMID 9195923 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Zhao S Sancar A Nov 1997 Human blue light photoreceptor hCRY2 specifically interacts with protein serine threonine phosphatase 5 and modulates its activity Photochemistry and Photobiology 66 5 727 31 doi 10 1111 j 1751 1097 1997 tb03214 x PMID 9383998 S2CID 32804361 Ollendorff V Donoghue DJ Dec 1997 The serine threonine phosphatase PP5 interacts with CDC16 and CDC27 two tetratricopeptide repeat containing subunits of the anaphase promoting complex The Journal of Biological Chemistry 272 51 32011 8 doi 10 1074 jbc 272 51 32011 PMID 9405394 Das AK Cohen PW Barford D Mar 1998 The structure of the tetratricopeptide repeats of protein phosphatase 5 implications for TPR mediated protein protein interactions The EMBO Journal 17 5 1192 9 doi 10 1093 emboj 17 5 1192 PMC 1170467 PMID 9482716 Russell LC Whitt SR Chen MS Chinkers M Jul 1999 Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90 The Journal of Biological Chemistry 274 29 20060 3 doi 10 1074 jbc 274 29 20060 PMID 10400612 Lubert EJ Hong Y Sarge KD Oct 2001 Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A evidence for a heterotrimeric form of protein phosphatase 5 The Journal of Biological Chemistry 276 42 38582 7 doi 10 1074 jbc M106906200 PMID 11504734 Morita K Saitoh M Tobiume K Matsuura H Enomoto S Nishitoh H Ichijo H Nov 2001 Negative feedback regulation of ASK1 by protein phosphatase 5 PP5 in response to oxidative stress The EMBO Journal 20 21 6028 36 doi 10 1093 emboj 20 21 6028 PMC 125685 PMID 11689443 Sanchez Ortiz E Hahm BK Armstrong DL Rossie S Oct 2009 Protein phosphatase 5 protects neurons against amyloid beta toxicity Journal of Neurochemistry 111 2 391 402 doi 10 1111 j 1471 4159 2009 06337 x PMC 3044491 PMID 19686245 Yamaguchi Y Katoh H Mori K Negishi M Aug 2002 Galpha 12 and Galpha 13 interact with Ser Thr protein phosphatase type 5 and stimulate its phosphatase activity Current Biology 12 15 1353 8 doi 10 1016 S0960 9822 02 01034 5 PMID 12176367 S2CID 11485795 Gentile S Darden T Erxleben C Romeo C Russo A Martin N Rossie S Armstrong DL Mar 2006 Rac GTPase signaling through the PP5 protein phosphatase Proceedings of the National Academy of Sciences of the United States of America 103 13 5202 6 Bibcode 2006PNAS 103 5202G doi 10 1073 pnas 0600080103 PMC 1458818 PMID 16549782 Liu F Zaidi T Iqbal K Grundke Iqbal I Gong CX 2003 Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5 Neuroscience 115 3 829 37 doi 10 1016 S0306 4522 02 00510 9 PMID 12435421 S2CID 26118803 Urban G Golden T Aragon IV Cowsert L Cooper SR Dean NM Honkanen RE Mar 2003 Identification of a functional link for the p53 tumor suppressor protein in dexamethasone induced growth suppression The Journal of Biological Chemistry 278 11 9747 53 doi 10 1074 jbc M210993200 PMID 12519780 Tomsig JL Snyder SL Creutz CE Mar 2003 Identification of targets for calcium signaling through the copine family of proteins Characterization of a coiled coil copine binding motif The Journal of Biological Chemistry 278 12 10048 54 doi 10 1074 jbc M212632200 PMID 12522145 Matsuda A Suzuki Y Honda G Muramatsu S Matsuzaki O Nagano Y Doi T Shimotohno K Harada T Nishida E Hayashi H Sugano S May 2003 Large scale identification and characterization of human genes that activate NF kappaB and MAPK signaling pathways Oncogene 22 21 3307 18 doi 10 1038 sj onc 1206406 PMID 12761501 S2CID 38880905 Retrieved from https en wikipedia org w index php title PPP5C amp oldid 1190648830, wikipedia, wiki, book, books, library,
