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Ergotism

January 26, 2023

Ergotism (pron. /ˈɜːrɡətˌɪzəm/ UR-gət-iz-əm) is the effect of long-term[citation needed] ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus—from the Latin clava "club" or clavus "nail" and -ceps for "head", i.e. the purple club-headed fungus—that infects rye and other cereals, and more recently by the action of a number of ergoline-based drugs. It is also known as ergotoxicosis, ergot poisoning, and Saint Anthony's fire.

Ergotism
Other namesSaint Anthony's fire, ergotoxicosis
Advanced ergotism with gangrene
SpecialtyEmergency medicine 
Symptoms
TypesConvulsive, gangrenous
CausesLong-term ergot poisoning

Signs and symptoms

The symptoms can be roughly divided into convulsive symptoms and gangrenous symptoms.[citation needed]

Convulsive

 
Convulsive symptoms of ergotism

Convulsive symptoms include painful seizures and spasms, diarrhea, paresthesias, itching, mental effects including mania or psychosis, headaches, nausea and vomiting. Usually the gastrointestinal effects precede central nervous system effects.[citation needed]

Gangrenous

The dry gangrene is a result of vasoconstriction induced by the ergotamine-ergocristine alkaloids of the fungus.[citation needed] It affects the more poorly vascularized distal structures, such as the fingers and toes. Symptoms include desquamation or peeling, weak peripheral pulses, loss of peripheral sensation, edema and ultimately the death and loss of affected tissues. Vasoconstriction is treated with vasodilators.[1]

Causes

 
Claviceps purpurea fungal sclerotia growing on barley

Historically, eating grain products, particularly rye, contaminated with the fungus Claviceps purpurea was the cause of ergotism.[citation needed]

The toxic ergoline derivatives are found in ergot-based drugs (such as methylergometrine, ergotamine or, previously, ergotoxine). The deleterious side effects occur either under high dose or when moderate doses interact with potentiators such as erythromycin.[citation needed]

The alkaloids can pass through lactation from mother to child, causing ergotism in infants.[citation needed]

Identification of agent

 
Ergot in barley

Dark-purple or black grain kernels, known as ergot bodies, can be identifiable in the heads of cereal or grass just before harvest. In most plants the ergot bodies are larger than normal grain kernels, but can be smaller if the grain is a type of wheat.[citation needed]

Prevention

Removal of ergot bodies is done by placing the yield in a brine solution; the ergot bodies float, while the healthy grains sink.[2] Infested fields must be deep-ploughed; ergot cannot germinate if buried more than one inch (2.5 cm) in soil[citation needed] and therefore will not release its spores into the air. Rotating crops using non-susceptible plants helps reduce infestations, since ergot spores live only one year.[citation needed] Crop rotation and deep tillage, such as deep mold-board ploughing, are important components in managing ergot, as many cereal crops in the 21st century are sown with a "no-till" practice (new crops are sown directly into the stubble from the previous crop to reduce soil erosion).[3] Wild and escaped grasses and pastures can be mown before they flower to help limit the spread of ergot.

Chemical controls can also be used but are not considered economical, especially in commercial operations, and germination of ergot spores can still occur under favourable conditions even with the use of such controls.

History

 
Detail from the painting Temptation of St Anthony by Matthias Grünewald, showing a patient with advanced ergotism

Epidemics of the disease were identified throughout history, though the references in classical writings are inconclusive. Rye, the main vector (route) for transmitting ergotism, was not grown much around the Mediterranean. When Fuchs separated references to ergotism from erysipelas and other conditions in 1834, he found the earliest reference to ergotism in the Annales Xantenses for the year 857: "a great plague of swollen blisters consumed the people by a loathsome rot, so that their limbs were loosened and fell off before death".[citation needed]

In the Middle Ages the gangrenous poisoning was known as "holy fire" or "Saint Anthony's fire", named after monks of the Order of St. Anthony, who were particularly successful at treating this ailment. According to Snorri Sturluson, in his Heimskringla, King Magnus II of Norway, son of King Harald Sigurtharson, who was the half-brother of Saint King Olaf Haraldsson, died from ergotism shortly after the Battle of Hastings. The 12th-century chronicler Geoffroy du Breuil of Vigeois recorded the mysterious outbreaks in the Limousin region of France, where the gangrenous form of ergotism was associated with the local Saint Martial. Likewise, an outbreak in Paris around 1129 was reported to be cured by the relics of Saint Genevieve, a miracle commemorated in the 26 November "Feast of the Burning Ones".[4]

The blight, named cockspur[5] owing to the appearance of infected grains, was identified and named by Denis Dodart, who reported the relation between ergotized rye and bread poisoning in a letter to the French Royal Academy of Sciences in 1676 (John Ray mentioned ergot for the first time in English the next year). "Ergotism", in this modern sense, was first recorded in 1853.[citation needed]

Notable epidemics of ergotism occurred into the 19th century. Fewer outbreaks have occurred since then owing to rye being carefully monitored in developed countries. However, a severe outbreak of something akin to ergot poisoning occurred in the French village of Pont-Saint-Esprit in 1951, resulting in five deaths.[6] The outbreak and the diagnostic confusion surrounding it are vividly described in John Grant Fuller's book The Day of St Anthony's Fire.[7]

There is evidence[8] of ergot poisoning serving a ritual purpose in the ritual killing of certain bog bodies.[9]

When milled, the ergot is reduced to a red powder,[10] obvious in lighter grasses but easy to miss in dark rye flour. In less wealthy countries, ergotism still occurs; an outbreak in Ethiopia occurred in mid-2001 from contaminated barley. Whenever there is a combination of moist weather, cool temperatures, delayed harvest in lowland crops and rye consumption, an outbreak is possible.

Poisonings due to consumption of seeds treated with mercury compounds are sometimes misidentified as ergotism.[11][12] Simon Cotton of the Chemistry Department of Uppingham School, UK, said that there have been numerous cases of mass-poisoning due to consumption of mercury-treated seeds.[13]

Salem witchcraft accusations

The convulsive symptoms from ergot-tainted rye may have been the source of accusations of bewitchment that spurred the Salem witch trials. This medical explanation for the theory of "bewitchment" was first propounded by Linnda R. Caporael in 1976 in an article in Science.[14] In her article, Caporael argues that the convulsive symptoms, such as crawling sensations in the skin, tingling in the fingers, vertigo, tinnitus aurium, headaches, disturbances in sensation, hallucination, painful muscular contractions, vomiting, and diarrhea, as well as psychological symptoms, such as mania, melancholia, psychosis, and delirium, were all symptoms reported in the Salem witchcraft records. Caporael also states that there was an abundance of rye in the region, as well as climate conditions that could support the tainting of rye.[15] In 1982, historian Mary Matossian raised Caporael's theory in an article in American Scientist, in which she argued that symptoms of "bewitchment" resemble the ones exhibited in those affected by ergot poisoning.[16]

The hypothesis that ergotism could explain cases of bewitchment has been subject to debate and has been criticized by several scholars. Within a year of Caporael's article, historians Spanos and Gottlieb argued against the idea in the same journal. In Spanos and Gottlieb's rebuttal to Caporael's article, they concluded that there are several flaws in the explanation. For example, they argued that, if the food supply were contaminated, the symptoms would have occurred by household, not individual. However, historian Leon Harrier said that even if supplies were properly cooked, residents with stomach ulcers had a risk of absorbing the toxin through the stomach lining, offering a direct route to the bloodstream. Being chemically similar to lysergic acid diethylamide (LSD), ergot would not survive in the acidic environment of a typical human's stomach, especially in properly cooked food. But if some but not all residents were malnourished and had bleeding stomach ulcers, only they could be affected by ingesting contaminated grains, leaving the majority unaffected, explaining why ergotism was not previously recognized. Harrier argued that the numbers could have been larger, possibly including the entire town, but due to the trials on bewitchment and heresy, and the fear of being accused and subsequently executed, few could come forward who had legitimate medical conditions.[citation needed]

Spanos and Gottlieb also state that ergot poisoning has additional symptoms not associated with the events in Salem and that the proportion of children affected was less than in a typical ergotism epidemic.[17] Anthropologist H. Sidky noted that ergotism had been known for centuries before the Salem witch trials and argued that its symptoms would have been recognizable during the time of the Salem witch trials.[18]

In 2003 it was pointed out that ergots produced by different strains of Claviceps purpurea, and those growing in different soils, may produce different ergot alkaloid compositions. This may explain the different manifestations of ergotism in different outbreaks. For example, an alkaloid present in high concentrations in ergots from Europe east of the Rhine may have caused convulsive ergotism, while ergot from the west caused epidemics of gangrenous ergotism.[19]

See also

References

  1. ^ Piquemal R, Emmerich J, Guilmot JL, Fiessinger JN (June 1998). "Successful treatment of ergotism with Iloprost—a case report". Angiology. 49 (6): 493–497. doi:10.1177/000331979804900612. PMID 9631897. S2CID 6348648.
  2. ^ Wegulo, Stephen N.; Carlson, Michael P. (2011). "Ergot of Small Grain Cereals and Grasses and Its Health Effects on Humans and Livestock" (PDF). University of Nebraska–Lincoln Extension.
  3. ^ "American Phytopathological Society". American Phytopathological Society.
  4. ^ Missale Parisiense (Paris: Jean Dupré, 1481), fol. 241r, accessed via Gallica, [1].
  5. ^ "cockspur". Oxford English Dictionary (Online ed.). Oxford University Press. (Subscription or participating institution membership required.)
  6. ^ Richards, Ira S. (2008). Principles and Practice of Toxicology in Public Health. Sudbury, MA: Jones & Bartlett. p. 64. ISBN 978-0-7637-3823-5.
  7. ^ Fuller, John (1969). The Day of St Anthony's Fire. London: Hutchinson. ISBN 0-09-095460-2.
  8. ^ Taylor, Timothy (2003), The Buried Soul: How Humans Invented Death, Fourth Estate.[page needed]
  9. ^ Stødkilde-Jørgensen, Hans; Jacobsen, Niels Otto; Warncke, Esbern; Heinemeier, Jan (March 2008). "The intestines of a more than 2000 years old peat-bog man: microscopy, magnetic resonance imaging and 14C-dating". Journal of Archaeological Science. 35 (3): 530–534. doi:10.1016/j.jas.2007.05.010.
  10. ^ Cadwick, Ian. "Bread, Madness and Christianity". Scripturient Blog Commentary. 9 Nov. 2013. Web. 30 Nov. 2014.
  11. ^ Ott, Jonathan (1993), Pharmacotheon: Entheogenic Drugs, their Plant Sources and History, Kennewick, WA: Natural Products, p. 145.
  12. ^ Hofmann, Albert (1980), "1: How LSD Originated", LSD: My Problem Child, New York, NY: McGraw-Hill, p. 6, archived from the original on 2016-05-22.
  13. ^ Cotton, Simon (October 2003), "Dimethylmercury and Mercury Poisoning", Molecule of the Month, UK: School of Chemistry, University of Bristol, More horrifying than this were epidemics of poisoning, caused by people eating treated seed grains. There was a serious epidemic in Iraq in 1956 and again in 1960, whilst use of seed wheat (which had been treated with a mixture of C2H5HgCl and C6H5HgOCOCH3) for food, caused the poisoning of about 100 people in West Pakistan in 1961. Another outbreak happened in Guatemala in 1965. Most serious was the disaster in Iraq in 1971–2, when according to official figures 459 died. Grain had been treated with methyl mercury compounds as a fungicide and should have been planted. Instead it was sold for milling and made into bread. It had been dyed red as a warning and also had warning labels in English and Spanish that no one could understand..
  14. ^ Caporael, Linnda R. (April 1976). "Ergotism: The Satan Loose in Salem". Science. 192 (4234): 21–26. Bibcode:1976Sci...192...21C. doi:10.1126/science.769159. PMID 769159.
  15. ^ Caporael, Linnda R. (April 1976). "Ergotism: The Satan Loose in Salem". Science. 192 (4234): 21–26. Bibcode:1976Sci...192...21C. doi:10.1126/science.769159. PMID 769159.
  16. ^ Matossian, Mary (July–August 1982). "Ergot and the Salem Witchcraft Affair". American Scientist. 70 (4): 355–357. Bibcode:1982AmSci..70..355M. PMID 6756230.
  17. ^ Spanos, Nicholas; Gottlieb, John 'Jack' (December 1976). "Ergotism and the Salem Village Witch Trials". Science. 194 (4272): 1390–1394. Bibcode:1976Sci...194.1390S. doi:10.1126/science.795029. PMID 795029. S2CID 41615273.
  18. ^ Sidky, H. (1997). Witchcraft, Lycanthropy, Drugs and Disease: An Anthropological Study of the European Witch Hunts. Peter Lang. ISBN 0-8204-3354-3.[page needed]
  19. ^ Eadie M. J. (July 2003). "Convulsive ergotism: epidemics of the serotonin syndrome?". Lancet Neurology. 2 (7): 429–434. doi:10.1016/S1474-4422(03)00439-3. PMID 12849122. S2CID 12158282.

External links

  •   Media related to Ergotism at Wikimedia Commons

January 26, 2023
ergotism, pron, ɜːr, gət, effect, long, term, citation, needed, ergot, poisoning, traditionally, ingestion, alkaloids, produced, claviceps, purpurea, fungus, from, latin, clava, club, clavus, nail, ceps, head, purple, club, headed, fungus, that, infects, other. Ergotism pron ˈ ɜːr ɡ e t ˌ ɪ z e m UR get iz em is the effect of long term citation needed ergot poisoning traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus from the Latin clava club or clavus nail and ceps for head i e the purple club headed fungus that infects rye and other cereals and more recently by the action of a number of ergoline based drugs It is also known as ergotoxicosis ergot poisoning and Saint Anthony s fire ErgotismOther namesSaint Anthony s fire ergotoxicosisAdvanced ergotism with gangreneSpecialtyEmergency medicine SymptomsConvulsive ergotism spasms diarrhea paresthesias mania psychosis headaches nausea vomiting Gangrenous ergotism desquamation weak peripheral pulses loss of peripheral sensation edemaTypesConvulsive gangrenousCausesLong term ergot poisoning Contents 1 Signs and symptoms 1 1 Convulsive 1 2 Gangrenous 2 Causes 2 1 Identification of agent 3 Prevention 4 History 4 1 Salem witchcraft accusations 5 See also 6 References 7 External linksSigns and symptoms EditThe symptoms can be roughly divided into convulsive symptoms and gangrenous symptoms citation needed Convulsive Edit Convulsive symptoms of ergotism Convulsive symptoms include painful seizures and spasms diarrhea paresthesias itching mental effects including mania or psychosis headaches nausea and vomiting Usually the gastrointestinal effects precede central nervous system effects citation needed Gangrenous Edit The dry gangrene is a result of vasoconstriction induced by the ergotamine ergocristine alkaloids of the fungus citation needed It affects the more poorly vascularized distal structures such as the fingers and toes Symptoms include desquamation or peeling weak peripheral pulses loss of peripheral sensation edema and ultimately the death and loss of affected tissues Vasoconstriction is treated with vasodilators 1 Causes Edit Claviceps purpurea fungal sclerotia growing on barley Historically eating grain products particularly rye contaminated with the fungus Claviceps purpurea was the cause of ergotism citation needed The toxic ergoline derivatives are found in ergot based drugs such as methylergometrine ergotamine or previously ergotoxine The deleterious side effects occur either under high dose or when moderate doses interact with potentiators such as erythromycin citation needed The alkaloids can pass through lactation from mother to child causing ergotism in infants citation needed Identification of agent Edit Ergot in barley Dark purple or black grain kernels known as ergot bodies can be identifiable in the heads of cereal or grass just before harvest In most plants the ergot bodies are larger than normal grain kernels but can be smaller if the grain is a type of wheat citation needed Prevention EditRemoval of ergot bodies is done by placing the yield in a brine solution the ergot bodies float while the healthy grains sink 2 Infested fields must be deep ploughed ergot cannot germinate if buried more than one inch 2 5 cm in soil citation needed and therefore will not release its spores into the air Rotating crops using non susceptible plants helps reduce infestations since ergot spores live only one year citation needed Crop rotation and deep tillage such as deep mold board ploughing are important components in managing ergot as many cereal crops in the 21st century are sown with a no till practice new crops are sown directly into the stubble from the previous crop to reduce soil erosion 3 Wild and escaped grasses and pastures can be mown before they flower to help limit the spread of ergot Chemical controls can also be used but are not considered economical especially in commercial operations and germination of ergot spores can still occur under favourable conditions even with the use of such controls History Edit Detail from the painting Temptation of St Anthony by Matthias Grunewald showing a patient with advanced ergotism Epidemics of the disease were identified throughout history though the references in classical writings are inconclusive Rye the main vector route for transmitting ergotism was not grown much around the Mediterranean When Fuchs separated references to ergotism from erysipelas and other conditions in 1834 he found the earliest reference to ergotism in the Annales Xantenses for the year 857 a great plague of swollen blisters consumed the people by a loathsome rot so that their limbs were loosened and fell off before death citation needed In the Middle Ages the gangrenous poisoning was known as holy fire or Saint Anthony s fire named after monks of the Order of St Anthony who were particularly successful at treating this ailment According to Snorri Sturluson in his Heimskringla King Magnus II of Norway son of King Harald Sigurtharson who was the half brother of Saint King Olaf Haraldsson died from ergotism shortly after the Battle of Hastings The 12th century chronicler Geoffroy du Breuil of Vigeois recorded the mysterious outbreaks in the Limousin region of France where the gangrenous form of ergotism was associated with the local Saint Martial Likewise an outbreak in Paris around 1129 was reported to be cured by the relics of Saint Genevieve a miracle commemorated in the 26 November Feast of the Burning Ones 4 The blight named cockspur 5 owing to the appearance of infected grains was identified and named by Denis Dodart who reported the relation between ergotized rye and bread poisoning in a letter to the French Royal Academy of Sciences in 1676 John Ray mentioned ergot for the first time in English the next year Ergotism in this modern sense was first recorded in 1853 citation needed Notable epidemics of ergotism occurred into the 19th century Fewer outbreaks have occurred since then owing to rye being carefully monitored in developed countries However a severe outbreak of something akin to ergot poisoning occurred in the French village of Pont Saint Esprit in 1951 resulting in five deaths 6 The outbreak and the diagnostic confusion surrounding it are vividly described in John Grant Fuller s book The Day of St Anthony s Fire 7 There is evidence 8 of ergot poisoning serving a ritual purpose in the ritual killing of certain bog bodies 9 When milled the ergot is reduced to a red powder 10 obvious in lighter grasses but easy to miss in dark rye flour In less wealthy countries ergotism still occurs an outbreak in Ethiopia occurred in mid 2001 from contaminated barley Whenever there is a combination of moist weather cool temperatures delayed harvest in lowland crops and rye consumption an outbreak is possible Poisonings due to consumption of seeds treated with mercury compounds are sometimes misidentified as ergotism 11 12 Simon Cotton of the Chemistry Department of Uppingham School UK said that there have been numerous cases of mass poisoning due to consumption of mercury treated seeds 13 Salem witchcraft accusations Edit The convulsive symptoms from ergot tainted rye may have been the source of accusations of bewitchment that spurred the Salem witch trials This medical explanation for the theory of bewitchment was first propounded by Linnda R Caporael in 1976 in an article in Science 14 In her article Caporael argues that the convulsive symptoms such as crawling sensations in the skin tingling in the fingers vertigo tinnitus aurium headaches disturbances in sensation hallucination painful muscular contractions vomiting and diarrhea as well as psychological symptoms such as mania melancholia psychosis and delirium were all symptoms reported in the Salem witchcraft records Caporael also states that there was an abundance of rye in the region as well as climate conditions that could support the tainting of rye 15 In 1982 historian Mary Matossian raised Caporael s theory in an article in American Scientist in which she argued that symptoms of bewitchment resemble the ones exhibited in those affected by ergot poisoning 16 The hypothesis that ergotism could explain cases of bewitchment has been subject to debate and has been criticized by several scholars Within a year of Caporael s article historians Spanos and Gottlieb argued against the idea in the same journal In Spanos and Gottlieb s rebuttal to Caporael s article they concluded that there are several flaws in the explanation For example they argued that if the food supply were contaminated the symptoms would have occurred by household not individual However historian Leon Harrier said that even if supplies were properly cooked residents with stomach ulcers had a risk of absorbing the toxin through the stomach lining offering a direct route to the bloodstream Being chemically similar to lysergic acid diethylamide LSD ergot would not survive in the acidic environment of a typical human s stomach especially in properly cooked food But if some but not all residents were malnourished and had bleeding stomach ulcers only they could be affected by ingesting contaminated grains leaving the majority unaffected explaining why ergotism was not previously recognized Harrier argued that the numbers could have been larger possibly including the entire town but due to the trials on bewitchment and heresy and the fear of being accused and subsequently executed few could come forward who had legitimate medical conditions citation needed Spanos and Gottlieb also state that ergot poisoning has additional symptoms not associated with the events in Salem and that the proportion of children affected was less than in a typical ergotism epidemic 17 Anthropologist H Sidky noted that ergotism had been known for centuries before the Salem witch trials and argued that its symptoms would have been recognizable during the time of the Salem witch trials 18 In 2003 it was pointed out that ergots produced by different strains of Claviceps purpurea and those growing in different soils may produce different ergot alkaloid compositions This may explain the different manifestations of ergotism in different outbreaks For example an alkaloid present in high concentrations in ergots from Europe east of the Rhine may have caused convulsive ergotism while ergot from the west caused epidemics of gangrenous ergotism 19 See also EditDancing plague of 1518 Great Fear of 1789References Edit Piquemal R Emmerich J Guilmot JL Fiessinger JN June 1998 Successful treatment of ergotism with Iloprost a case report Angiology 49 6 493 497 doi 10 1177 000331979804900612 PMID 9631897 S2CID 6348648 Wegulo Stephen N Carlson Michael P 2011 Ergot of Small Grain Cereals and Grasses and Its Health Effects on Humans and Livestock PDF University of Nebraska Lincoln Extension American Phytopathological Society American Phytopathological Society Missale Parisiense Paris Jean Dupre 1481 fol 241r accessed via Gallica 1 cockspur Oxford English Dictionary Online ed Oxford University Press Subscription or participating institution membership required Richards Ira S 2008 Principles and Practice of Toxicology in Public Health Sudbury MA Jones amp Bartlett p 64 ISBN 978 0 7637 3823 5 Fuller John 1969 The Day of St Anthony s Fire London Hutchinson ISBN 0 09 095460 2 Taylor Timothy 2003 The Buried Soul How Humans Invented Death Fourth Estate page needed Stodkilde Jorgensen Hans Jacobsen Niels Otto Warncke Esbern Heinemeier Jan March 2008 The intestines of a more than 2000 years old peat bog man microscopy magnetic resonance imaging and 14C dating Journal of Archaeological Science 35 3 530 534 doi 10 1016 j jas 2007 05 010 Cadwick Ian Bread Madness and Christianity Scripturient Blog Commentary 9 Nov 2013 Web 30 Nov 2014 Ott Jonathan 1993 Pharmacotheon Entheogenic Drugs their Plant Sources and History Kennewick WA Natural Products p 145 Hofmann Albert 1980 1 How LSD Originated LSD My Problem Child New York NY McGraw Hill p 6 archived from the original on 2016 05 22 Cotton Simon October 2003 Dimethylmercury and Mercury Poisoning Molecule of the Month UK School of Chemistry University of Bristol More horrifying than this were epidemics of poisoning caused by people eating treated seed grains There was a serious epidemic in Iraq in 1956 and again in 1960 whilst use of seed wheat which had been treated with a mixture of C2H5HgCl and C6H5HgOCOCH3 for food caused the poisoning of about 100 people in West Pakistan in 1961 Another outbreak happened in Guatemala in 1965 Most serious was the disaster in Iraq in 1971 2 when according to official figures 459 died Grain had been treated with methyl mercury compounds as a fungicide and should have been planted Instead it was sold for milling and made into bread It had been dyed red as a warning and also had warning labels in English and Spanish that no one could understand Caporael Linnda R April 1976 Ergotism The Satan Loose in Salem Science 192 4234 21 26 Bibcode 1976Sci 192 21C doi 10 1126 science 769159 PMID 769159 Caporael Linnda R April 1976 Ergotism The Satan Loose in Salem Science 192 4234 21 26 Bibcode 1976Sci 192 21C doi 10 1126 science 769159 PMID 769159 Matossian Mary July August 1982 Ergot and the Salem Witchcraft Affair American Scientist 70 4 355 357 Bibcode 1982AmSci 70 355M PMID 6756230 Spanos Nicholas Gottlieb John Jack December 1976 Ergotism and the Salem Village Witch Trials Science 194 4272 1390 1394 Bibcode 1976Sci 194 1390S doi 10 1126 science 795029 PMID 795029 S2CID 41615273 Sidky H 1997 Witchcraft Lycanthropy Drugs and Disease An Anthropological Study of the European Witch Hunts Peter Lang ISBN 0 8204 3354 3 page needed Eadie M J July 2003 Convulsive ergotism epidemics of the serotonin syndrome Lancet Neurology 2 7 429 434 doi 10 1016 S1474 4422 03 00439 3 PMID 12849122 S2CID 12158282 External links Edit Media related to Ergotism at Wikimedia Commons Retrieved from https en wikipedia org w index php title Ergotism amp oldid 1132992079, wikipedia, wiki, book, books, library,

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