fbpx
Wikipedia

CC chemokine receptors

December 07, 2023

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

CCR1
Identifiers
SymbolCCR1
NCBI gene1230
HGNC1602
OMIM601159
RefSeqNM_001295
UniProtP32246
Other data
LocusChr. 3 p21
Search for
StructuresSwiss-model
DomainsInterPro
CCR2
Identifiers
SymbolCCR2
NCBI gene1231
HGNC1603
OMIM601268
PDB1KAD
RefSeqNM_000647
UniProtP41597
Other data
LocusChr. 3 p21
Search for
StructuresSwiss-model
DomainsInterPro
CCR3
Identifiers
SymbolCCR3
NCBI gene1232
HGNC1604
OMIM601268
RefSeqNM_001837
UniProtP51677
Other data
LocusChr. 3 p21
Search for
StructuresSwiss-model
DomainsInterPro
CCR4
Identifiers
SymbolCCR4
NCBI gene1233
HGNC1605
OMIM604836
RefSeqNM_005508
UniProtP51679
Other data
LocusChr. 3 p24
Search for
StructuresSwiss-model
DomainsInterPro
CCR5
Identifiers
SymbolCCR5
NCBI gene1234
HGNC1606
OMIM601373
PDB1ND8
RefSeqNM_000579
UniProtP51681
Other data
LocusChr. 3 p21
Search for
StructuresSwiss-model
DomainsInterPro
CCR6
Identifiers
SymbolCCR6
NCBI gene1235
HGNC1607
OMIM601835
RefSeqNM_004367
UniProtP51684
Other data
LocusChr. 6 q27
Search for
StructuresSwiss-model
DomainsInterPro
CCR7
Identifiers
SymbolCCR7
NCBI gene1236
HGNC1608
OMIM600242
RefSeqNM_001838
UniProtP32248
Other data
LocusChr. 17 q12-q21.2
Search for
StructuresSwiss-model
DomainsInterPro
CCR8
Identifiers
SymbolCCR8
NCBI gene1237
HGNC1609
OMIM601834
RefSeqNM_005201
UniProtP51685
Other data
LocusChr. 3 p22
Search for
StructuresSwiss-model
DomainsInterPro
CCR9
Identifiers
SymbolCCR9
NCBI gene10803
HGNC1610
OMIM604738
RefSeqNM_031200
UniProtP51686
Other data
LocusChr. 3 p21
Search for
StructuresSwiss-model
DomainsInterPro
CCR10
Identifiers
SymbolCCR10
NCBI gene2826
HGNC4474
OMIM600240
RefSeqNM_016602
UniProtP46092
Other data
LocusChr. 17 17q21.1-q21
Search for
StructuresSwiss-model
DomainsInterPro

Mechanism edit

The CC chemokine receptors all work by activating the G protein Gi.[1]

Types edit

Overview table edit

CCR1 edit

CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory/inducible (see inducible gene) CC chemokines (including CCL4, CCL5, CCL6, CCL14, CCL15, CCL16 and CCL23).[2][3][4] In humans, this receptor can be found on peripheral blood lymphocytes and monocytes. There is some suggestion that this chemokine receptor is restricted to memory T-cells within the lymphocyte pool. This receptor is also designated cluster of differentiation marker CD191.

CCR2 edit

CCR2 can interact with CCL2, CCL8 and CCL16 and has been identified on the surface of monocytes, activated memory T cells, B cells, and basophils in humans, and also in peritoneal macrophages in mice.[4][5] CCR2 is also designated CD192.

CCR3 edit

CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and CCL5 that attract eosinophils, and CCL28 that attracts B and T lymphocytes to mucosal tissues.[3][6][7][8][9] It is most highly expressed in both eosinophils and basophils, but can also be found in Th1 and Th2 cells and airway epithelial cells. Thus CCR3 plays a role in allergic reactions. CCR3 is also known as CD193.

CCR4 edit

CCR4 is expressed on Th2 T lymphocytes and is up-regulated by T cell receptor activation. However, some reports suggest a role for this receptor also in trafficking of dendritic cells. The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor.[10][11]

CCR5 edit

CCR5 is expressed on several cell types including peripheral blood-derived dendritic cells, CD34+ hematopoietic progenitor cells and certain activated/memory Th1 lymphocytes. This receptor is well defined as a major coreceptor implicated in susceptibility to HIV-1 infection and disease. This receptor has several CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14 and CCL16.[4][5][12][13]

CCR6 edit

CCR6, a receptor for CCL20, is expressed on unactivated memory T-cells and some dendritic cells. CCR6 is also expressed on Th17 cells.[14] CCR6 is down-regulated in activated T-cells.[15]

CCR7 edit

CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes and dendritic cells to and across high endothelial venules and positioning those cells correctly in T cell zones of secondary lymphoid organs. Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC).[16]

CCR8 edit

CCR8 is associated with Th2 lymphocytes and is therefore found predominantly in the thymus (in humans) although some expression can be found in the brain, spleen, lymph node, and monocytes at the nucleotide level. The ligands for this receptor are CCL1 and CCL16[17]

CCR9 edit

CCR9 was previously called orphan receptor GPR 9-6 and is very highly expressed in thymus (on both immature and mature T-cells) while low in lymph nodes and spleen. CCR9 is also abundant in the gut, with its expression associated with T cells of the intestine. The specific ligand of this receptor is CCL25[18] To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is a scavenger receptor not a true (signaling) chemokine receptor.

CCR10 edit

CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2.[8][19][20][21] CCR10 has been implicated in inflammation of the skin, and has been shown to recruit regulatory T cells (Tregs) to mucosal layers.

CCR11 edit

This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and CCL25) and its structural similarity to chemokine receptors. However, due to the inability of this molecule (also known as CCRL1 and CCX CKR) to generate a signal following ligand interaction, it has been suggested that it is a scavenger receptor for chemokines and not a bona fide chemokine receptor. Thus CCRL1 should not be called CCR11 under the guidelines of the IUIS/WHO Subcommittee on Chemokine Nomenclature.

References edit

  1. ^ senselab
  2. ^ Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA (February 2004). "The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling". Journal of Immunology. 172 (3): 1872–81. doi:10.4049/jimmunol.172.3.1872. PMID 14734772.
  3. ^ a b Youn BS, Zhang SM, Lee EK, Park DH, Broxmeyer HE, Murphy PM, et al. (December 1997). "Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3". Journal of Immunology. 159 (11): 5201–5. doi:10.4049/jimmunol.159.11.5201. PMID 9548457. S2CID 20622216.
  4. ^ a b c Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, et al. (August 2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology. 13 (8): 1021–9. doi:10.1093/intimm/13.8.1021. PMID 11470772.
  5. ^ a b Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (April 2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood. 97 (7): 1920–4. doi:10.1182/blood.v97.7.1920. PMID 11264152.
  6. ^ Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, et al. (September 1999). "Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3". The Journal of Biological Chemistry. 274 (39): 27975–80. doi:10.1074/jbc.274.39.27975. PMID 10488147.
  7. ^ Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, et al. (March 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
  8. ^ a b Pan J, Kunkel EJ, Gosslar U, Lazarus N, Langdon P, Broadwell K, et al. (September 2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". Journal of Immunology. 165 (6): 2943–9. doi:10.4049/jimmunol.165.6.2943. PMID 10975800.
  9. ^ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, et al. (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". Journal of Leukocyte Biology. 62 (5): 667–75. doi:10.1002/jlb.62.5.667. PMID 9365122. S2CID 12197497.
  10. ^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". The Journal of Biological Chemistry. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
  11. ^ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, et al. (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". The Journal of Biological Chemistry. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
  12. ^ Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, et al. (February 1998). "Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication". The Journal of Biological Chemistry. 273 (8): 4289–92. doi:10.1074/jbc.273.8.4289. PMID 9468473.
  13. ^ Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, et al. (September 1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist". Blood. 94 (6): 1899–905. doi:10.1182/blood.V94.6.1899. PMID 10477718.
  14. ^ Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, et al. (June 2007). "Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells". Nature Immunology. 8 (6): 639–46. doi:10.1038/ni1467. PMID 17486092. S2CID 21824460.
  15. ^ Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, et al. (June 1997). "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC". The Journal of Biological Chemistry. 272 (23): 14893–8. doi:10.1074/jbc.272.23.14893. PMID 9169459.
  16. ^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, et al. (May 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". The Journal of Biological Chemistry. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
  17. ^ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". The Journal of Biological Chemistry. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
  18. ^ Zaballos A, Gutiérrez J, Varona R, Ardavín C, Márquez G (May 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". Journal of Immunology. 162 (10): 5671–5. doi:10.4049/jimmunol.162.10.5671. PMID 10229797. S2CID 21522407.
  19. ^ Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ (March 2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". Journal of Immunology. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
  20. ^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
  21. ^ Wang W, Soto H, Oldham ER, Buchanan ME, Homey B, Catron D, et al. (July 2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". The Journal of Biological Chemistry. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.

External links edit

  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-11-25.

December 07, 2023
chemokine, receptors, beta, chemokine, receptors, integral, membrane, proteins, that, specifically, bind, respond, cytokines, chemokine, family, they, represent, subfamily, chemokine, receptors, large, family, protein, linked, receptors, that, known, seven, tr. CC chemokine receptors or beta chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family They represent one subfamily of chemokine receptors a large family of G protein linked receptors that are known as seven transmembrane 7 TM proteins since they span the cell membrane seven times To date ten true members of the CC chemokine receptor subfamily have been described These are named CCR1 to CCR10 according to the IUIS WHO Subcommittee on Chemokine Nomenclature CCR1IdentifiersSymbolCCR1NCBI gene1230HGNC1602OMIM601159RefSeqNM 001295UniProtP32246Other dataLocusChr 3 p21Search forStructuresSwiss modelDomainsInterProCCR2IdentifiersSymbolCCR2NCBI gene1231HGNC1603OMIM601268PDB1KADRefSeqNM 000647UniProtP41597Other dataLocusChr 3 p21Search forStructuresSwiss modelDomainsInterProCCR3IdentifiersSymbolCCR3NCBI gene1232HGNC1604OMIM601268RefSeqNM 001837UniProtP51677Other dataLocusChr 3 p21Search forStructuresSwiss modelDomainsInterProCCR4IdentifiersSymbolCCR4NCBI gene1233HGNC1605OMIM604836RefSeqNM 005508UniProtP51679Other dataLocusChr 3 p24Search forStructuresSwiss modelDomainsInterProCCR5IdentifiersSymbolCCR5NCBI gene1234HGNC1606OMIM601373PDB1ND8RefSeqNM 000579UniProtP51681Other dataLocusChr 3 p21Search forStructuresSwiss modelDomainsInterProCCR6IdentifiersSymbolCCR6NCBI gene1235HGNC1607OMIM601835RefSeqNM 004367UniProtP51684Other dataLocusChr 6 q27Search forStructuresSwiss modelDomainsInterProCCR7IdentifiersSymbolCCR7NCBI gene1236HGNC1608OMIM600242RefSeqNM 001838UniProtP32248Other dataLocusChr 17 q12 q21 2Search forStructuresSwiss modelDomainsInterProCCR8IdentifiersSymbolCCR8NCBI gene1237HGNC1609OMIM601834RefSeqNM 005201UniProtP51685Other dataLocusChr 3 p22Search forStructuresSwiss modelDomainsInterProCCR9IdentifiersSymbolCCR9NCBI gene10803HGNC1610OMIM604738RefSeqNM 031200UniProtP51686Other dataLocusChr 3 p21Search forStructuresSwiss modelDomainsInterProCCR10IdentifiersSymbolCCR10NCBI gene2826HGNC4474OMIM600240RefSeqNM 016602UniProtP46092Other dataLocusChr 17 17q21 1 q21Search forStructuresSwiss modelDomainsInterPro Contents 1 Mechanism 2 Types 2 1 Overview table 2 2 CCR1 2 3 CCR2 2 4 CCR3 2 5 CCR4 2 6 CCR5 2 7 CCR6 2 8 CCR7 2 9 CCR8 2 10 CCR9 2 11 CCR10 2 12 CCR11 3 References 4 External linksMechanism editThe CC chemokine receptors all work by activating the G protein Gi 1 Types editOverview table edit Receptor LigandsCCR1 CCL4 CCL5 CCL6 CCL14 CCL15 CCL16 CCL23CCR2 CCL2 CCL8 CCL16CCR3 CCL11 CCL26 CCL7 CCL13 CCL15 CCL24 CCL5 CCL28 CCL18CCR4 CCL3 CCL5 CCL17 CCL22CCR5 CCL3 CCL4 CCL5 CCL8 CCL11 CCL13 CCL14 CCL16CCR6 CCL20CCR7 CCL19 CCL21CCR8 CCL1 CCL16CCR9 CCL25CCR10 CCL27 CCL28CCR11 CCL19 CCL21 CCL25CCR1 edit CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory inducible see inducible gene CC chemokines including CCL4 CCL5 CCL6 CCL14 CCL15 CCL16 and CCL23 2 3 4 In humans this receptor can be found on peripheral blood lymphocytes and monocytes There is some suggestion that this chemokine receptor is restricted to memory T cells within the lymphocyte pool This receptor is also designated cluster of differentiation marker CD191 CCR2 edit CCR2 can interact with CCL2 CCL8 and CCL16 and has been identified on the surface of monocytes activated memory T cells B cells and basophils in humans and also in peritoneal macrophages in mice 4 5 CCR2 is also designated CD192 CCR3 edit CCR3 is a receptor for multiple inflammatory inducible CC chemokines including CCL11 CCL26 CCL7 CCL13 CCL15 CCL24 and CCL5 that attract eosinophils and CCL28 that attracts B and T lymphocytes to mucosal tissues 3 6 7 8 9 It is most highly expressed in both eosinophils and basophils but can also be found in Th1 and Th2 cells and airway epithelial cells Thus CCR3 plays a role in allergic reactions CCR3 is also known as CD193 CCR4 edit CCR4 is expressed on Th2 T lymphocytes and is up regulated by T cell receptor activation However some reports suggest a role for this receptor also in trafficking of dendritic cells The CC chemokines CCL3 CCL5 CCL17 and CCL22 signal through this receptor 10 11 CCR5 edit CCR5 is expressed on several cell types including peripheral blood derived dendritic cells CD34 hematopoietic progenitor cells and certain activated memory Th1 lymphocytes This receptor is well defined as a major coreceptor implicated in susceptibility to HIV 1 infection and disease This receptor has several CC chemokine ligands including CCL2 CCL3 CCL4 CCL5 CCL11 CCL13 CCL14 and CCL16 4 5 12 13 CCR6 edit CCR6 a receptor for CCL20 is expressed on unactivated memory T cells and some dendritic cells CCR6 is also expressed on Th17 cells 14 CCR6 is down regulated in activated T cells 15 CCR7 edit CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes and dendritic cells to and across high endothelial venules and positioning those cells correctly in T cell zones of secondary lymphoid organs Its ligands include the related chemokines CCL19 and CCL21 previously called ELC and SLC 16 CCR8 edit CCR8 is associated with Th2 lymphocytes and is therefore found predominantly in the thymus in humans although some expression can be found in the brain spleen lymph node and monocytes at the nucleotide level The ligands for this receptor are CCL1 and CCL16 17 CCR9 edit CCR9 was previously called orphan receptor GPR 9 6 and is very highly expressed in thymus on both immature and mature T cells while low in lymph nodes and spleen CCR9 is also abundant in the gut with its expression associated with T cells of the intestine The specific ligand of this receptor is CCL25 18 To note the chemokine binding protein D6 had previously been named CCR9 but this molecule is a scavenger receptor not a true signaling chemokine receptor CCR10 edit CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2 8 19 20 21 CCR10 has been implicated in inflammation of the skin and has been shown to recruit regulatory T cells Tregs to mucosal layers CCR11 edit This molecule was originally designated CCR11 due to its ability to bind several CC chemokines including CCL19 CCL21 and CCL25 and its structural similarity to chemokine receptors However due to the inability of this molecule also known as CCRL1 and CCX CKR to generate a signal following ligand interaction it has been suggested that it is a scavenger receptor for chemokines and not a bona fide chemokine receptor Thus CCRL1 should not be called CCR11 under the guidelines of the IUIS WHO Subcommittee on Chemokine Nomenclature References edit senselab Ma B Zhu Z Homer RJ Gerard C Strieter R Elias JA February 2004 The C10 CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL 13 induced inflammation and remodeling Journal of Immunology 172 3 1872 81 doi 10 4049 jimmunol 172 3 1872 PMID 14734772 a b Youn BS Zhang SM Lee EK Park DH Broxmeyer HE Murphy PM et al December 1997 Molecular cloning of leukotactin 1 a novel human beta chemokine a chemoattractant for neutrophils monocytes and lymphocytes and a potent agonist at CC chemokine receptors 1 and 3 Journal of Immunology 159 11 5201 5 doi 10 4049 jimmunol 159 11 5201 PMID 9548457 S2CID 20622216 a b c Nomiyama H Hieshima K Nakayama T Sakaguchi T Fujisawa R Tanase S et al August 2001 Human CC chemokine liver expressed chemokine CCL16 is a functional ligand for CCR1 CCR2 and CCR5 and constitutively expressed by hepatocytes International Immunology 13 8 1021 9 doi 10 1093 intimm 13 8 1021 PMID 11470772 a b Ogilvie P Bardi G Clark Lewis I Baggiolini M Uguccioni M April 2001 Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5 Blood 97 7 1920 4 doi 10 1182 blood v97 7 1920 PMID 11264152 Kitaura M Suzuki N Imai T Takagi S Suzuki R Nakajima T et al September 1999 Molecular cloning of a novel human CC chemokine Eotaxin 3 that is a functional ligand of CC chemokine receptor 3 The Journal of Biological Chemistry 274 39 27975 80 doi 10 1074 jbc 274 39 27975 PMID 10488147 Kitaura M Nakajima T Imai T Harada S Combadiere C Tiffany HL et al March 1996 Molecular cloning of human eotaxin an eosinophil selective CC chemokine and identification of a specific eosinophil eotaxin receptor CC chemokine receptor 3 The Journal of Biological Chemistry 271 13 7725 30 doi 10 1074 jbc 271 13 7725 PMID 8631813 a b Pan J Kunkel EJ Gosslar U Lazarus N Langdon P Broadwell K et al September 2000 A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues Journal of Immunology 165 6 2943 9 doi 10 4049 jimmunol 165 6 2943 PMID 10975800 White JR Imburgia C Dul E Appelbaum E O Donnell K O Shannessy DJ et al November 1997 Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils Journal of Leukocyte Biology 62 5 667 75 doi 10 1002 jlb 62 5 667 PMID 9365122 S2CID 12197497 Imai T Baba M Nishimura M Kakizaki M Takagi S Yoshie O June 1997 The T cell directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 The Journal of Biological Chemistry 272 23 15036 42 doi 10 1074 jbc 272 23 15036 PMID 9169480 Imai T Chantry D Raport CJ Wood CL Nishimura M Godiska R et al January 1998 Macrophage derived chemokine is a functional ligand for the CC chemokine receptor 4 The Journal of Biological Chemistry 273 3 1764 8 doi 10 1074 jbc 273 3 1764 PMID 9430724 Gong W Howard OM Turpin JA Grimm MC Ueda H Gray PW et al February 1998 Monocyte chemotactic protein 2 activates CCR5 and blocks CD4 CCR5 mediated HIV 1 entry replication The Journal of Biological Chemistry 273 8 4289 92 doi 10 1074 jbc 273 8 4289 PMID 9468473 Blanpain C Migeotte I Lee B Vakili J Doranz BJ Govaerts C et al September 1999 CCR5 binds multiple CC chemokines MCP 3 acts as a natural antagonist Blood 94 6 1899 905 doi 10 1182 blood V94 6 1899 PMID 10477718 Acosta Rodriguez EV Rivino L Geginat J Jarrossay D Gattorno M Lanzavecchia A et al June 2007 Surface phenotype and antigenic specificity of human interleukin 17 producing T helper memory cells Nature Immunology 8 6 639 46 doi 10 1038 ni1467 PMID 17486092 S2CID 21824460 Baba M Imai T Nishimura M Kakizaki M Takagi S Hieshima K et al June 1997 Identification of CCR6 the specific receptor for a novel lymphocyte directed CC chemokine LARC The Journal of Biological Chemistry 272 23 14893 8 doi 10 1074 jbc 272 23 14893 PMID 9169459 Yoshida R Imai T Hieshima K Kusuda J Baba M Kitaura M et al May 1997 Molecular cloning of a novel human CC chemokine EBI1 ligand chemokine that is a specific functional ligand for EBI1 CCR7 The Journal of Biological Chemistry 272 21 13803 9 doi 10 1074 jbc 272 21 13803 PMID 9153236 Roos RS Loetscher M Legler DF Clark Lewis I Baggiolini M Moser B July 1997 Identification of CCR8 the receptor for the human CC chemokine I 309 The Journal of Biological Chemistry 272 28 17251 4 doi 10 1074 jbc 272 28 17251 PMID 9211859 Zaballos A Gutierrez J Varona R Ardavin C Marquez G May 1999 Cutting edge identification of the orphan chemokine receptor GPR 9 6 as CCR9 the receptor for the chemokine TECK Journal of Immunology 162 10 5671 5 doi 10 4049 jimmunol 162 10 5671 PMID 10229797 S2CID 21522407 Gosling J Dairaghi DJ Wang Y Hanley M Talbot D Miao Z Schall TJ March 2000 Cutting edge identification of a novel chemokine receptor that binds dendritic cell and T cell active chemokines including ELC SLC and TECK Journal of Immunology 164 6 2851 6 doi 10 4049 jimmunol 164 6 2851 PMID 10706668 Homey B Wang W Soto H Buchanan ME Wiesenborn A Catron D et al April 2000 Cutting edge the orphan chemokine receptor G protein coupled receptor 2 GPR 2 CCR10 binds the skin associated chemokine CCL27 CTACK ALP ILC Journal of Immunology 164 7 3465 70 doi 10 4049 jimmunol 164 7 3465 PMID 10725697 Wang W Soto H Oldham ER Buchanan ME Homey B Catron D et al July 2000 Identification of a novel chemokine CCL28 which binds CCR10 GPR2 The Journal of Biological Chemistry 275 29 22313 23 doi 10 1074 jbc M001461200 PMID 10781587 External links edit Chemokine Receptors IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2008 11 25 Retrieved from https en wikipedia org w index php title CC chemokine receptors amp oldid 1188115072, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.