Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.[7]
CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression.
^ abcGRCh38: Ensembl release 89: ENSG00000183813 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047898 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi:10.1074/jbc.270.33.19495. PMID 7642634.
^Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.
^Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
^Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
^ abFDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017
External links
Human CCR4 genome location and CCR4 gene details page in the UCSC Genome Browser.
ccr4, chemokine, receptor, type, protein, that, humans, encoded, gene, also, recently, been, designated, cd194, cluster, differentiation, identifiersaliases, cd194, ckr4, cmkbr4, chemr13, hgcn, 14099, motif, chemokine, receptor, 4external, idsomim, 604836, 107. C C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene 5 6 7 CCR4 has also recently been designated CD194 cluster of differentiation 194 CCR4IdentifiersAliasesCCR4 CC CKR 4 CD194 CKR4 CMKBR4 ChemR13 HGCN 14099 K5 5 C C motif chemokine receptor 4External IDsOMIM 604836 MGI 107824 HomoloGene 21135 GeneCards CCR4Gene location Human Chr Chromosome 3 human 1 Band3p22 3Start32 951 644 bp 1 End32 956 349 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 F3 9 64 49 cMStart114 319 384 bp 2 End114 333 984 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inappendixlymph nodegallbladdermonocytebloodbone marrow cellsrectumspleenright lungupper lobe of left lungTop expressed inthymusmorulayolk saclipmeningesspermatidzone of skinjejunumspleendigastric muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionC C chemokine receptor activity G protein coupled receptor activity chemokine receptor activity signal transducer activity protein binding chemokine binding C C chemokine bindingCellular componentintegral component of membrane plasma membrane integral component of plasma membrane external side of plasma membrane membrane neuronal cell body intracellular anatomical structureBiological processpositive regulation of cytosolic calcium ion concentration chemotaxis chemokine mediated signaling pathway inflammatory response neuron migration homeostasis of number of cells immune response signal transduction tolerance induction response to bacterium response to antibiotic response to radiation positive regulation of positive chemotaxis G protein coupled receptor signaling pathway calcium mediated signaling cell chemotaxisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez123312773EnsemblENSG00000183813ENSMUSG00000047898UniProtP51679P51680RefSeq mRNA NM 005508NM 009916RefSeq protein NP 005499NP 034046Location UCSC Chr 3 32 95 32 96 MbChr 9 114 32 114 33 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene belongs to the G protein coupled receptor family It is a receptor for the following CC chemokines CCL2 MCP 1 CCL4 MIP 1 CCL5 RANTES CCL17 TARC 8 CCL22 Macrophage derived chemokine 9 Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes The chemokines also play fundamental roles in the development homeostasis and function of the immune system and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis 7 CCR4 is a cell surface protein and should not be confused with the unrelated carbon catabolite repression negative on TATA less CCR4 Not a nuclear protein complex that regulates gene expression Contents 1 Clinical significance 1 1 As a drug target 2 References 3 External linksClinical significance EditCCR4 is often expressed on leukemic cells in cutaneous T cell lymphoma CTCL 10 As a drug target Edit Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL 10 References Edit a b c GRCh38 Ensembl release 89 ENSG00000183813 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000047898 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Power CA Meyer A Nemeth K Bacon KB Hoogewerf AJ Proudfoot AE Wells TN Sep 1995 Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line J Biol Chem 270 33 19495 500 doi 10 1074 jbc 270 33 19495 PMID 7642634 Samson M Soularue P Vassart G Parmentier M Feb 1997 The genes encoding the human CC chemokine receptors CC CKR1 to CC CKR5 CMKBR1 CMKBR5 are clustered in the p21 3 p24 region of chromosome 3 Genomics 36 3 522 6 doi 10 1006 geno 1996 0498 PMID 8884276 a b Entrez Gene CCR4 chemokine C C motif receptor 4 Imai T Baba M Nishimura M Kakizaki M Takagi S Yoshie O June 1997 The T cell directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 J Biol Chem 272 23 15036 42 doi 10 1074 jbc 272 23 15036 PMID 9169480 Imai T Chantry D Raport CJ Wood CL Nishimura M Godiska R Yoshie O Gray PW January 1998 Macrophage derived chemokine is a functional ligand for the CC chemokine receptor 4 J Biol Chem 273 3 1764 8 doi 10 1074 jbc 273 3 1764 PMID 9430724 a b FDA grants priority review to mogamulizumab for cutaneous T cell lymphoma Nov 2017External links EditHuman CCR4 genome location and CCR4 gene details page in the UCSC Genome Browser CCR4 receptor at the US National Library of Medicine Medical Subject Headings MeSH Chemokine Receptors CCR4 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology This article incorporates text from the United States National Library of Medicine which is in the public domain This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CCR4 amp oldid 1099503780, wikipedia, wiki, book, books, library,
