Chemokine receptor 6 also known as CCR6 is a CC chemokine receptorprotein which in humans is encoded by the CCR6gene.[5] CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).[5]
This protein belongs to family A of G protein-coupled receptor superfamily. The gene is expressed in lymphatic and non-lymphatic tissue as spleen, lymph nodes, pancreas, colon, appendix, small intestine. CCR6 is expressed on B-cells, immature dendritic cells (DC), T-cells (Th1, Th2, Th17, Treg), natural killer T cells (NKT cells) and neutrophils.[6] The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha). This chemokine receptor is special because it binds only one chemokine ligand CCL20 in compare to other chemokine receptors.[7] CCR6 has a key role in connection between immature DC an adaptive immunity.[8] This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.[9]
Interleukin 4 (IL-4) and interferon gamma (IFNγ) suppress expression of CCR6 in langerhans cells development and interleukin 10 (IL-10) induces the expression. It can regulate immune response in inflammatory tissue.[10]
Proinflammatory Th17 cells express CCR6 and its ligand CCL20. CCR6 influences their migration to sites of inflammation. Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T-cells (Treg). This can lead to chronic inflammation. In some models, the lack of CCR6 leads to less severe autoimmune encephalomyelitis.[11]
Clinical significanceedit
CCR6 has a function in development and metastatic spread of gastrointestinal malignancies.[7] Expression of CCR6 was found to be up-regulated in colorectal cancer.[12] Many patients with colorectal cancer have liver metastases. Colorectal carcinoma cells express CCR6 and CCL20. High level of CCL20 in liver chemoattract colorectal carcinoma cells and cause metastases in liver.[7][13] Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines.[14]
CCR6 has been associated with Crohn's disease.[15]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000112486 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040899 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abZaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (October 1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020.
^Schutyser, Evemie; Struyf, Sofie; Van Damme, Jo (October 2003). "The CC chemokine CCL20 and its receptor CCR6". Cytokine & Growth Factor Reviews. 14 (5): 409–426. doi:10.1016/s1359-6101(03)00049-2. ISSN 1359-6101. PMID 12948524.
^ abcFrick, Vilma Oliveira; Rubie, Claudia; Keilholz, Ulrich; Ghadjar, Pirus (2016-01-14). "Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview". World Journal of Gastroenterology. 22 (2): 833–841. doi:10.3748/wjg.v22.i2.833. ISSN 2219-2840. PMC4716081. PMID 26811629.
^Dieu, M. C.; Vanbervliet, B.; Vicari, A.; Bridon, J. M.; Oldham, E.; Aït-Yahia, S.; Brière, F.; Zlotnik, A.; Lebecque, S.; Caux, C. (1998-07-20). "Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites". The Journal of Experimental Medicine. 188 (2): 373–386. doi:10.1084/jem.188.2.373. ISSN 0022-1007. PMC2212459. PMID 9670049.
^Dieu-Nosjean, Marie-Caroline; Massacrier, Catherine; Vanbervliet, Béatrice; Fridman, Wolf-Herman; Caux, Christophe (2001-11-15). "IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-γ Suppress It". The Journal of Immunology. 167 (10): 5594–5602. doi:10.4049/jimmunol.167.10.5594. ISSN 0022-1767. PMID 11698430.
^Yamazaki, Tomohide; Yang, Xuexian O.; Chung, Yeonseok; Fukunaga, Atsushi; Nurieva, Roza; Pappu, Bhanu; Martin-Orozco, Natalia; Kang, Hong Soon; Ma, Li; Panopoulos, Athanasia D.; Craig, Suzanne (2008-12-15). "CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells". The Journal of Immunology. 181 (12): 8391–8401. doi:10.4049/jimmunol.181.12.8391. ISSN 0022-1767. PMC2752441. PMID 19050256.
^Rubie, Claudia; Kruse, Bianca; Frick, Vilma Oliveira; Kölsch, Kathrin; Ghadjar, Pirus; Wagner, Mathias; Grässer, Friedrich; Wagenpfeil, Stefan; Glanemann, Mathias (2014-02-21). "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells". Journal of Translational Medicine. 12: 48. doi:10.1186/1479-5876-12-48. ISSN 1479-5876. PMC3996063. PMID 24559209.
^Frick, V. O.; .Rubie, C.; Kölsch, K.; Wagner, M.; Ghadjar, P.; Graeber, S.; Glanemann, M. (September 2013). "CCR6/CCL20 Chemokine Expression Profile in Distinct Colorectal Malignancies". Scandinavian Journal of Immunology. 78 (3): 298–305. doi:10.1111/sji.12087. PMID 23790181. S2CID 45126701.
^Rubie C (Feb 2014). "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells". J Transl Med. 12: 48. doi:10.1186/1479-5876-12-48. PMC3996063. PMID 24559209.
^Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H (February 2009). "Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease". Am. J. Hum. Genet. 84 (3): 399–405. doi:10.1016/j.ajhg.2009.01.026. PMC2668006. PMID 19249008.
External linksedit
Human CCR6 genome location and CCR6 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further readingedit
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zaballos A, Varona R, Gutiérrez J, et al. (1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020.
Liao F, Lee HH, Farber JM (1997). "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27". Genomics. 40 (1): 175–80. doi:10.1006/geno.1996.4544. PMID 9070937.
Baba M, Imai T, Nishimura M, et al. (1997). "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC". J. Biol. Chem. 272 (23): 14893–8. doi:10.1074/jbc.272.23.14893. PMID 9169459.
Wagner T, Tommerup N, Wirth J, et al. (1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3". Cytogenet. Cell Genet. 76 (3–4): 172–5. doi:10.1159/000134538. PMID 9186513.
Liao F, Alderson R, Su J, et al. (1997). "STRL22 is a receptor for the CC chemokine MIP-3alpha". Biochem. Biophys. Res. Commun. 236 (1): 212–7. doi:10.1006/bbrc.1997.6936. PMID 9223454.
Power CA, Church DJ, Meyer A, et al. (1997). "Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells". J. Exp. Med. 186 (6): 825–35. doi:10.1084/jem.186.6.825. PMC2199050. PMID 9294137.
Greaves DR, Wang W, Dairaghi DJ, et al. (1997). "CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells". J. Exp. Med. 186 (6): 837–44. doi:10.1084/jem.186.6.837. PMC2199049. PMID 9294138.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yang D, Chertov O, Bykovskaia SN, et al. (1999). "Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6". Science. 286 (5439): 525–8. doi:10.1126/science.286.5439.525. PMID 10521347.
Krzysiek R, Lefevre EA, Bernard J, et al. (2000). "Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells". Blood. 96 (7): 2338–45. doi:10.1182/blood.V96.7.2338. PMID 11001880.
Douglas GC, Thirkill TL, Sideris V, et al. (2001). "Chemokine receptor expression by human syncytiotrophoblast". J. Reprod. Immunol. 49 (2): 97–114. doi:10.1016/S0165-0378(00)00083-8. PMID 11164896.
Biragyn A, Surenhu M, Yang D, et al. (2002). "Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens". J. Immunol. 167 (11): 6644–53. doi:10.4049/jimmunol.167.11.6644. PMID 11714836.
Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes". J. Immunol. 168 (1): 65–72. doi:10.4049/jimmunol.168.1.65. PMID 11751947.
Liao F, Shirakawa AK, Foley JF, et al. (2002). "Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding". J. Immunol. 168 (10): 4871–80. doi:10.4049/jimmunol.168.10.4871. PMID 11994436.
Hosokawa Y, Nakanishi T, Yamaguchi D, et al. (2002). "Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue". Clin. Exp. Immunol. 128 (3): 548–54. doi:10.1046/j.1365-2249.2002.01865.x. PMC1906256. PMID 12067311.
Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001. S2CID 37076470.
Ai LS, Liao F (2002). "Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling". Biochemistry. 41 (26): 8332–41. doi:10.1021/bi025855y. PMID 12081481.
Hoover DM, Boulegue C, Yang D, et al. (2002). "The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins". J. Biol. Chem. 277 (40): 37647–54. doi:10.1074/jbc.M203907200. PMID 12149255.
Maki W, Morales RE, Carroll VA, et al. (2002). "CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells". J. Immunol. 169 (5): 2346–53. doi:10.4049/jimmunol.169.5.2346. PMID 12193700.
chemokine, receptor, type, chemokine, receptor, also, known, ccr6, chemokine, receptor, protein, which, humans, encoded, ccr6, gene, ccr6, also, recently, been, designated, cd196, cluster, differentiation, gene, located, long, chromosome, 6q27, watson, plus, s. Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene 5 CCR6 has also recently been designated CD196 cluster of differentiation 196 The gene is located on the long arm of Chromosome 6 6q27 on the Watson plus strand It is 139 737 bases long and encodes a protein of 374 amino acids molecular weight 42 494 Da 5 CCR6IdentifiersAliasesCCR6 BN 1 C C CKR 6 CC CKR 6 CCR 6 CD196 CKR L3 CKRL3 CMKBR6 DCR2 DRY6 GPR29 GPRCY4 STRL22 C C motif chemokine receptor 6External IDsOMIM 601835 MGI 1333797 HomoloGene 3214 GeneCards CCR6Gene location Human Chr Chromosome 6 human 1 Band6q27Start167 111 807 bp 1 End167 139 141 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 A1Start8 454 875 bp 2 End8 475 973 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodeappendixspleenbloodduodenumgallbladderrectumthymusbone marrowprefrontal cortexTop expressed inspleenlymph nodebloodsubcutaneous adipose tissuespermatidthymuscarotid bodyright lung lobeseminiferous tubulesuperior frontal gyrusMore reference expression dataBioGPSn aGene ontologyMolecular functionG protein coupled receptor activity signal transducer activity chemokine receptor activity protein binding C C chemokine receptor activity C C chemokine binding signaling receptor activity chemokine bindingCellular componentintegral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure cell surface sperm midpiece sperm flagellum sperm principal piece sperm plasma membrane external side of plasma membraneBiological processpositive regulation of cytosolic calcium ion concentration positive regulation of epithelial cell migration dendritic cell chemotaxis cellular defense response humoral immune response immune response positive regulation of dendritic cell chemotaxis signal transduction calcium mediated signaling chemotaxis cell chemotaxis chemokine mediated signaling pathway leukocyte migration involved in inflammatory response isotype switching to IgA isotypes positive regulation of flagellated sperm motility involved in capacitation lymphocyte migration T cell migration thymocyte migration DN2 thymocyte differentiation DN3 thymocyte differentiation regulation of T cell migration G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez123512458EnsemblENSG00000112486ENSMUSG00000040899UniProtP51684O54689RefSeq mRNA NM 031409NM 004367NM 001394582NM 001190333NM 001190334NM 001190335NM 001190336NM 001190337NM 001190338NM 009835RefSeq protein NP 004358NP 113597NP 001177262NP 001177263NP 001177264NP 001177265NP 001177266NP 001177267NP 033965Location UCSC Chr 6 167 11 167 14 MbChr 17 8 45 8 48 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 References 4 External links 5 Further readingFunction editThis protein belongs to family A of G protein coupled receptor superfamily The gene is expressed in lymphatic and non lymphatic tissue as spleen lymph nodes pancreas colon appendix small intestine CCR6 is expressed on B cells immature dendritic cells DC T cells Th1 Th2 Th17 Treg natural killer T cells NKT cells and neutrophils 6 The ligand of this receptor is CCL20 or in the other name macrophage inflammatory protein 3 alpha MIP 3 alpha This chemokine receptor is special because it binds only one chemokine ligand CCL20 in compare to other chemokine receptors 7 CCR6 has a key role in connection between immature DC an adaptive immunity 8 This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses Alternatively spliced transcript variants that encode the same protein have been described for this gene 9 Interleukin 4 IL 4 and interferon gamma IFNg suppress expression of CCR6 in langerhans cells development and interleukin 10 IL 10 induces the expression It can regulate immune response in inflammatory tissue 10 Proinflammatory Th17 cells express CCR6 and its ligand CCL20 CCR6 influences their migration to sites of inflammation Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T cells Treg This can lead to chronic inflammation In some models the lack of CCR6 leads to less severe autoimmune encephalomyelitis 11 Clinical significance editCCR6 has a function in development and metastatic spread of gastrointestinal malignancies 7 Expression of CCR6 was found to be up regulated in colorectal cancer 12 Many patients with colorectal cancer have liver metastases Colorectal carcinoma cells express CCR6 and CCL20 High level of CCL20 in liver chemoattract colorectal carcinoma cells and cause metastases in liver 7 13 Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines 14 CCR6 has been associated with Crohn s disease 15 References edit a b c GRCh38 Ensembl release 89 ENSG00000112486 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000040899 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Zaballos A Varona R Gutierrez J Lind P Marquez G October 1996 Molecular cloning and RNA expression of two new human chemokine receptor like genes Biochem Biophys Res Commun 227 3 846 53 doi 10 1006 bbrc 1996 1595 PMID 8886020 Schutyser Evemie Struyf Sofie Van Damme Jo October 2003 The CC chemokine CCL20 and its receptor CCR6 Cytokine amp Growth Factor Reviews 14 5 409 426 doi 10 1016 s1359 6101 03 00049 2 ISSN 1359 6101 PMID 12948524 a b c Frick Vilma Oliveira Rubie Claudia Keilholz Ulrich Ghadjar Pirus 2016 01 14 Chemokine chemokine receptor pair CCL20 CCR6 in human colorectal malignancy An overview World Journal of Gastroenterology 22 2 833 841 doi 10 3748 wjg v22 i2 833 ISSN 2219 2840 PMC 4716081 PMID 26811629 Dieu M C Vanbervliet B Vicari A Bridon J M Oldham E Ait Yahia S Briere F Zlotnik A Lebecque S Caux C 1998 07 20 Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites The Journal of Experimental Medicine 188 2 373 386 doi 10 1084 jem 188 2 373 ISSN 0022 1007 PMC 2212459 PMID 9670049 Entrez Gene CCR6 chemokine C C motif receptor 6 Dieu Nosjean Marie Caroline Massacrier Catherine Vanbervliet Beatrice Fridman Wolf Herman Caux Christophe 2001 11 15 IL 10 Induces CCR6 Expression During Langerhans Cell Development While IL 4 and IFN g Suppress It The Journal of Immunology 167 10 5594 5602 doi 10 4049 jimmunol 167 10 5594 ISSN 0022 1767 PMID 11698430 Yamazaki Tomohide Yang Xuexian O Chung Yeonseok Fukunaga Atsushi Nurieva Roza Pappu Bhanu Martin Orozco Natalia Kang Hong Soon Ma Li Panopoulos Athanasia D Craig Suzanne 2008 12 15 CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells The Journal of Immunology 181 12 8391 8401 doi 10 4049 jimmunol 181 12 8391 ISSN 0022 1767 PMC 2752441 PMID 19050256 Rubie Claudia Kruse Bianca Frick Vilma Oliveira Kolsch Kathrin Ghadjar Pirus Wagner Mathias Grasser Friedrich Wagenpfeil Stefan Glanemann Mathias 2014 02 21 Chemokine receptor CCR6 expression is regulated by miR 518a 5p in colorectal cancer cells Journal of Translational Medicine 12 48 doi 10 1186 1479 5876 12 48 ISSN 1479 5876 PMC 3996063 PMID 24559209 Frick V O Rubie C Kolsch K Wagner M Ghadjar P Graeber S Glanemann M September 2013 CCR6 CCL20 Chemokine Expression Profile in Distinct Colorectal Malignancies Scandinavian Journal of Immunology 78 3 298 305 doi 10 1111 sji 12087 PMID 23790181 S2CID 45126701 Rubie C Feb 2014 Chemokine receptor CCR6 expression is regulated by miR 518a 5p in colorectal cancer cells J Transl Med 12 48 doi 10 1186 1479 5876 12 48 PMC 3996063 PMID 24559209 Wang K Zhang H Kugathasan S Annese V Bradfield JP Russell RK Sleiman PM Imielinski M Glessner J Hou C Wilson DC Walters T Kim C Frackelton EC Lionetti P Barabino A Van Limbergen J Guthery S Denson L Piccoli D Li M Dubinsky M Silverberg M Griffiths A Grant SF Satsangi J Baldassano R Hakonarson H February 2009 Diverse Genome wide Association Studies Associate the IL12 IL23 Pathway with Crohn Disease Am J Hum Genet 84 3 399 405 doi 10 1016 j ajhg 2009 01 026 PMC 2668006 PMID 19249008 External links editHuman CCR6 genome location and CCR6 gene details page in the UCSC Genome Browser Chemokine Receptors CCR6 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Zaballos A Varona R Gutierrez J et al 1996 Molecular cloning and RNA expression of two new human chemokine receptor like genes Biochem Biophys Res Commun 227 3 846 53 doi 10 1006 bbrc 1996 1595 PMID 8886020 Liao F Lee HH Farber JM 1997 Cloning of STRL22 a new human gene encoding a G protein coupled receptor related to chemokine receptors and located on chromosome 6q27 Genomics 40 1 175 80 doi 10 1006 geno 1996 4544 PMID 9070937 Baba M Imai T Nishimura M et al 1997 Identification of CCR6 the specific receptor for a novel lymphocyte directed CC chemokine LARC J Biol Chem 272 23 14893 8 doi 10 1074 jbc 272 23 14893 PMID 9169459 Wagner T Tommerup N Wirth J et al 1997 A somatic cell hybrid panel for distal 17q GDIA1 maps to 17q25 3 Cytogenet Cell Genet 76 3 4 172 5 doi 10 1159 000134538 PMID 9186513 Liao F Alderson R Su J et al 1997 STRL22 is a receptor for the CC chemokine MIP 3alpha Biochem Biophys Res Commun 236 1 212 7 doi 10 1006 bbrc 1997 6936 PMID 9223454 Power CA Church DJ Meyer A et al 1997 Cloning and characterization of a specific receptor for the novel CC chemokine MIP 3alpha from lung dendritic cells J Exp Med 186 6 825 35 doi 10 1084 jem 186 6 825 PMC 2199050 PMID 9294137 Greaves DR Wang W Dairaghi DJ et al 1997 CCR6 a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells J Exp Med 186 6 837 44 doi 10 1084 jem 186 6 837 PMC 2199049 PMID 9294138 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Yang D Chertov O Bykovskaia SN et al 1999 Beta defensins linking innate and adaptive immunity through dendritic and T cell CCR6 Science 286 5439 525 8 doi 10 1126 science 286 5439 525 PMID 10521347 Krzysiek R Lefevre EA Bernard J et al 2000 Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein 3alpha CCL20 in human B cells Blood 96 7 2338 45 doi 10 1182 blood V96 7 2338 PMID 11001880 Douglas GC Thirkill TL Sideris V et al 2001 Chemokine receptor expression by human syncytiotrophoblast J Reprod Immunol 49 2 97 114 doi 10 1016 S0165 0378 00 00083 8 PMID 11164896 Biragyn A Surenhu M Yang D et al 2002 Mediators of innate immunity that target immature but not mature dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens J Immunol 167 11 6644 53 doi 10 4049 jimmunol 167 11 6644 PMID 11714836 Ebert LM McColl SR 2002 Up regulation of CCR5 and CCR6 on distinct subpopulations of antigen activated CD4 T lymphocytes J Immunol 168 1 65 72 doi 10 4049 jimmunol 168 1 65 PMID 11751947 Liao F Shirakawa AK Foley JF et al 2002 Human B cells become highly responsive to macrophage inflammatory protein 3 alpha CC chemokine ligand 20 after cellular activation without changes in CCR6 expression or ligand binding J Immunol 168 10 4871 80 doi 10 4049 jimmunol 168 10 4871 PMID 11994436 Hosokawa Y Nakanishi T Yamaguchi D et al 2002 Macrophage inflammatory protein 3alpha CC chemokine receptor 6 interactions play an important role in CD4 T cell accumulation in periodontal diseased tissue Clin Exp Immunol 128 3 548 54 doi 10 1046 j 1365 2249 2002 01865 x PMC 1906256 PMID 12067311 Kim CH Johnston B Butcher EC 2002 Trafficking machinery of NKT cells shared and differential chemokine receptor expression among V alpha 24 V beta 11 NKT cell subsets with distinct cytokine producing capacity Blood 100 1 11 6 doi 10 1182 blood 2001 12 0196 PMID 12070001 S2CID 37076470 Ai LS Liao F 2002 Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking ligand binding and signaling Biochemistry 41 26 8332 41 doi 10 1021 bi025855y PMID 12081481 Hoover DM Boulegue C Yang D et al 2002 The structure of human macrophage inflammatory protein 3alpha CCL20 Linking antimicrobial and CC chemokine receptor 6 binding activities with human beta defensins J Biol Chem 277 40 37647 54 doi 10 1074 jbc M203907200 PMID 12149255 Maki W Morales RE Carroll VA et al 2002 CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6 transduced Jurkat T cells J Immunol 169 5 2346 53 doi 10 4049 jimmunol 169 5 2346 PMID 12193700 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title C C chemokine receptor type 6 amp oldid 1174060444, wikipedia, wiki, book, books, library,
