Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24gene.[1] This gene is located on human chromosome 7.[2]
Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[4]
Referencesedit
^ abPatel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC2196270. PMID 9104803.
^Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
^White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. doi:10.1002/jlb.62.5.667. PMID 9365122. S2CID 12197497.
^Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209. S2CID 205404242.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
ccl24, chemokine, motif, ligand, also, known, myeloid, progenitor, inhibitory, factor, mpif, eosinophil, chemotactic, protein, eotaxin, protein, that, humans, encoded, gene, this, gene, located, human, chromosome, chemokine, motif, ligand, 24identifierssymbola. Chemokine C C motif ligand 24 CCL24 also known as myeloid progenitor inhibitory factor 2 MPIF 2 or eosinophil chemotactic protein 2 eotaxin 2 is a protein that in humans is encoded by the CCL24 gene 1 This gene is located on human chromosome 7 2 chemokine C C motif ligand 24IdentifiersSymbolCCL24Alt symbolsSCYA24 Ckb 6 MPIF 2 eotaxin 2NCBI gene6369HGNC10623OMIM602495PDB1EIGRefSeqNM 002991UniProtO00175Other dataLocusChr 7 q11 23Search forStructuresSwiss modelDomainsInterProFunction editCCL24 is a small cytokine belonging to the CC chemokine family CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils 3 This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils 1 Clinical significance editElevated levels of eotaxin 2 has been seen in patients with aspirin exacerbated respiratory disease AERD such as asthma People with lower plasma levels of eotaxin 2 have not been showing tendency to develop aspirin inducible asthma 4 References edit a b Patel VP Kreider BL Li Y Li H Leung K Salcedo T Nardelli B Pippalla V Gentz S Thotakura R Parmelee D Gentz R Garotta G April 1997 Molecular and functional characterization of two novel human C C chemokines as inhibitors of two distinct classes of myeloid progenitors J Exp Med 185 7 1163 72 doi 10 1084 jem 185 7 1163 PMC 2196270 PMID 9104803 Hillier LW Fulton RS Fulton LA et al July 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 White JR Imburgia C Dul E Appelbaum E O Donnell K O Shannessy DJ Brawner M Fornwald J Adamou J Elshourbagy NA Kaiser K Foley JJ Schmidt DB Johanson K Macphee C Moores K McNulty D Scott GF Schleimer RP Sarau HM November 1997 Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils J Leukoc Biol 62 5 667 75 doi 10 1002 jlb 62 5 667 PMID 9365122 S2CID 12197497 Palikhe NS Kim SH Cho BY Ye YM Choi GS Park HS October 2009 Genetic variability in CRTH2 polymorphism increases eotaxin 2 levels in patients with aspirin exacerbated respiratory disease Allergy 65 3 338 346 doi 10 1111 j 1398 9995 2009 02158 x PMID 19796209 S2CID 205404242 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CCL24 amp oldid 1184186308, wikipedia, wiki, book, books, library,
