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BioNTech

February 16, 2024

BioNTech SE (/biːˈɒntɛk/ bee-ON-tek; or /baɪˈɒntɛk/ bye-ON-tek[2] short for Biopharmaceutical New Technologies) is a German biotechnology company based in Mainz that develops and manufactures active immunotherapies for patient-specific approaches to the treatment of diseases. It develops pharmaceutical candidates based on messenger ribonucleic acid (mRNA) for use as individualized cancer immunotherapies, as vaccines against infectious diseases and as protein replacement therapies for rare diseases, and also engineered cell therapy, novel antibodies and small molecule immunomodulators as treatment options for cancer.

BioNTech SE
Headquarters in Mainz
Company typePublic
Nasdaq: BNTX
ISINUS09075V1026
IndustryBiotechnology
Founded2008; 16 years ago (2008)
Founders
Headquarters
Mainz
,
Germany
Number of locations
8 (2022)
Area served
Worldwide
Key people
ProductsBNT162b2
ServicesImmunotherapy
Revenue €17.3 billion (2022)
€12.6 billion (2022)
€9.43 billion (2022)
Total assets €23.3 billion (2022)
Total equity €20.1 billion (2022)
Number of employees
 4,530 (2022)
Websitebiontech.com
Footnotes / references
Biontech FY 2022 report[1]

The company has developed an mRNA-based human therapeutic for intravenous administration to bring individualized mRNA-based cancer immunotherapy to clinical trials and to establish its own manufacturing process.[3]

In 2020, BioNTech, partnering with Pfizer for testing and logistics, developed the RNA vaccine BNT162b2 for preventing COVID-19 infections, which at the time offered a 91% efficacy[4] in preventing confirmed COVID-19 occurring at least 7 days after the second dose of vaccine.[5] On 2 December 2020, temporary HMR authorization was granted by the United Kingdom government for BNT162b2 vaccinations within the United Kingdom.[6][7] It was the first mRNA vaccine ever authorized. Some days later the vaccine also received an emergency approval in the United States,[8] Canada[9] and Switzerland.[10] On 21 December 2020, the European Commission approved BioNTech/Pfizer's coronavirus vaccine in accordance with the positive recommendation of the European Medicines Agency (EMA).[11]

History edit

Foundation (2008–2013) edit

BioNTech was founded in 2008 based on research by Uğur Şahin, Özlem Türeci,[12] and Christoph Huber,[13] with a seed investment of €150 million from MIG Capital and AT Impf.[14] The company's activities focus on the development and production of technologies and drugs for individualized cancer immunotherapy.[3] Andreas and Thomas Strüngmann, Michael Motschmann, and Helmut Jeggle were cofounders.[15] In 2009, the acquisition of EUFETS and JPT Peptide Technologies took place.[16][17] Hungarian biochemist Katalin Karikó, whose work on mRNA whilst working at the University of Pennsylvania underpinned the development of Pfizer–BioNTech COVID-19 vaccine[18] (and who later shared the 2023 Nobel Prize in Physiology or Medicine,[19]) joined BioNTech as a senior vice president in 2013.[20]

Expansion (2014–2019) edit

Between 2014 and 2018, many research results on mRNA mechanisms were published by BioNTech.[21] Collaborations and commercialization programs were concluded with various companies and scientific institutions starting in 2015.[22] During this period, BioNTech filed several patent applications and developed a multi-layered strategy to protect its intellectual property in the various technology platforms and their application in the treatment of cancer and other serious diseases.[citation needed]

In August 2018, the company entered into a multi-year research and development (R&D) collaboration with the US company Pfizer, Inc. to develop mRNA-based vaccines for prevention of influenza. Under the terms of the agreement, following BioNTech's completion of a first-in-human clinical study, Pfizer would assume sole responsibility for further clinical development and commercialization of mRNA-based flu vaccines.[23]

In January 2019, Sanofi invested €80 million in BioNTech and extended the mRNA cancer research collaboration between the two companies; Sanofi previously paid US$60 million upfront for the rights to five discovery-stage immunotherapies of BioNTech in 2015.[24] In July 2019, Fidelity Management & Research Company led a Series B investment round totalling $325 million, with additional investments from Redmile Group, Invus, Mirae Asset Financial Group, Platinum Asset Management, Jebsen Capital, Steam Athena Capital, BioVeda China Fund and the Struengmann Family Office.[25][26] In September 2019, BioNTech received a capital contribution of US$55 million from the Bill & Melinda Gates Foundation, with the option of doubling that investment amount at a later date.[27]

Nasdaq IPO (2019) to COVID-19 edit

Since 10 October 2019, BioNTech, with its newly founded North American headquarters in Cambridge, Massachusetts, has been publicly traded as American Depository Shares (ADS) on the NASDAQ Global Select Market under the ticker symbol, BNTX.[28] BioNTech was able to generate total gross proceeds of 150 million dollars from the IPO.[29]

In 2021, BioNTech announced it would open its Asia headquarters in Singapore, and also open a vaccine manufacturing plant there, with support from the Singapore Economic Development Board.[30] The Singapore factory is expected to be operational by 2023 and produce hundreds of millions of doses of mRNA vaccines per year.[31] A collaboration with Fosun Pharma is planned to add a facility in China to produce a billion doses per year for China, Macau, Hong Kong, and Taiwan, though as of August 2021, the PRC had not approved any foreign-developed COVID-19 vaccines.[31] In July 2023,  BioNTech acquired the British startup Instadeep for £562 million ($682 million) in order to expand its activities in the area of artificial intelligence for drug discovery, design and development.[32][33]

Corporate affairs edit

Locations edit

 
 
Mainz
 
Idar-Oberstein
 
Martinsried
 
Neuried
 
Berlin
 
Marburg
class=notpageimage|
Locations of BioNTech in Germany. The other two are in the United States.

BioNTech's founding place and global headquarters is Mainz, Germany, where the COVID-19 vaccine was created. The company runs multiple sites in the country. Further research locations are in San Diego and Cambridge, Massachusetts, the latter of which also serves as the North American headquarters.
Additionally the company owns GMP-certified production facilities in Idar-Oberstein, Martinsried, Neuried, Bavaria, and Berlin. In November 2020, the company acquired facilities from Novartis in Marburg to ramp up its vaccine production.[34][35]

Financing edit

In December 2019, BioNTech received a €50 million loan, to finance the development of its patient-specific immunotherapies for the treatment of cancer and other serious diseases, from the European Investment Bank (EIB) as part of the European Commission Investment Plan for Europe.[36]

The EIB then signed a €100 million loan in June 2020, after an accelerated approval (two months for a process that usually takes more than a year). This financing helped BioNTech's vaccine trials and manufacturing. The EIB loan is part of the InnovFin Corporate Research Equity programme and the European Fund for Strategic Investments. This programme supports "innovative and higher-risk projects" backed by the European Investment Bank with a guarantee from the European Union budget.[37][38][39][40] On 17 March 2020, BioNTech received a $135 million investment from Fosun Pharma in exchange for 1.58 million shares in BioNTech and the future development and marketing rights of the mRNA vaccine BNT162b2 in China.[41] In June 2020, BioNTech received €250 million from Temasek Holdings (Singapore) via the purchase of ordinary shares and 4 years convertible notes, but also from other investors through a private placement of mandatory convertible bonds.[42] On 15 September 2020, the German Federal Ministry of Education and Research (BMBF) awarded a €375 million grant to BioNTech, to accelerate the development of the COVID-19 vaccine.[43]

Business activities edit

Vaccine development edit

See also: Pfizer–BioNTech COVID-19 vaccine and COVID-19 vaccine § Clinical trials started in 2020
 
Pfizer–BioNTech COVID-19 vaccine

"Project Lightspeed", the project to develop a novel mRNA technology for a COVID-19 vaccine, began in mid-January 2020 just days after the SARS-Cov-2 genetic sequence was first made public.[44] The company is partnered on this project with Pfizer[45] and Fosun.[46][47]

The production of the vaccine was followed by clinical trials, the success of which was a prerequisite for the commencement of marketing. On 9 November 2020, BioNTech and Pfizer announced that 43,500 people in 6 countries had received a test vaccine against COVID-19 with more than 90 percent effectiveness. On the basis of successful testing, they asked for the right to distribute vaccines in the United States, as well as in the European Union, the United Kingdom and Japan.[48]

Vaccine distribution timeline edit

In July 2020, BioNTech and pharmaceutical corporation Pfizer signed contracts to supply 120 million doses for Japan, 100 million doses for the United States at $19.50, and 40 million doses for the United Kingdom, if proven effective, safe, and licensed.[49][50][51][52] On 5 August 2020, Canada pre-ordered 20 million doses of the vaccine.[53] In September 2020, Germany privately ordered 30 million doses, outside the collective EU purchasing scheme.[54] On 5 November 2020, Australia pre-ordered 10 million doses.[55] On 9 November 2020, BioNTech-Pfizer released a positive interim analysis of a Phase III clinical trial in the United States. On 10 November 2020, BioNTech and Pfizer applied for an emergency use authorization (EUA) with the FDA, which was reviewed by mid-December.[56][57] The FDA released a document explaining that an EUA is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic."[58] On 11 November 2020, the European Union pre-ordered 300 million doses, at an initial price of €12 per dose. Under the agreement, the vaccine-producing pair, BioNTech and Pfizer are subject to a tightened legal obligation to bring all the experience they have gained to the EMA for review.[59][60] Belgium's budget state secretary Eva De Bleeker accidentally revealed the vaccine purchase price-per-dose agreed by the EU with various companies, with Oxford-AstraZeneca at €1.78; Johnson & Johnson at $8.50, Sanofi-GSK at €7.56, CureVac at €10, and Moderna at $18.[61] In the same month, Israel ordered 8 million doses at $23.50 a dose.[62][63] In the same month BioNTech-Pfizer submitted an EUA application in Canada.[64] On 2 December 2020, the United Kingdom granted conditional temporary authorization (under Regulation 174 of the Human Medicines Regulations 2012) for BNT162b2,[6] becoming the first country to approve an mRNA vaccine and the first Western country to approve a COVID-19 vaccine for national use.[7][65] In the same month, BNT162b2 was revealed to also be under evaluation for EUA status in several other countries.[66] On 15 December 2020, Fosun Pharma agreed a deal to deliver 100 million doses of the BioNTech-Pfizer vaccine to China,[67] with Hong Kong securing 7.5 million doses. On 21 December 2020, the European Medicines Agency (EMA) authorised a one-year conditional use of the BioNTech-Pfizer vaccine in the European Union. Emer Cooke, Director of the EMA, stated that the benefits of the vaccine far outweigh the potential risks.[68] On 26 December 2020, following the authorisation, initial mass vaccination against coronavirus commenced in Hungary and Slovakia.[69]

On 8 January 2021, the European Union ordered an additional 200 million doses of the vaccine, with an option for 100 million more.[70] On 25 June 2021, the US Food and Drug Administration (FDA) added a warning about the risk of rare heart inflammation (myocarditis) to the specifications of both Pfizer/BioNTech and Moderna vaccines. As of that date, there were already 138 million US citizens who had been vaccinated twice with one of the mRNA-based vaccines, according to the US Centers for Disease Control and Prevention (CDC).[71][72]

Cancer immunotherapy edit

In early 2023 BioNTech started a series of clinical trials in the United Kingdom for mRNA based immunotherapies targeting several types of cancer.[73] In November 2023, in an interview to German broadcaster ZDF, BioNTech CEO Uğur Şahin said the company expects a mRNA-based therapeutic cancer vaccine approval by 2030.[74]

Sponsorship edit

BioNTech, together with Pfizer, co-sponsored the Academy Awards ceremony in March 2022 as main sponsors.[75]

In the sponsorship, the pharmaceutical duo stated that the widespread use of their vaccines and booster shots has helped prevent Covid19 diseases and protect lives, and the film industry has partnered to promote vaccines, mask use and other prevention strategies. BioNTech's spectacular marketing promotional success in the 2022 Oscars' sponsorship was its ability to appear ahead of its huge pharma partner Pfizer in the promotional duo's ubiquitous roster. This was a significant achievement because by this time 'BioNTech' had been removed from the name of the vaccine in almost every language in the world, and their joint product was mostly referred to simply as 'Pfizer'.[76]

See also edit

References edit

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49°59′16″N 8°16′17″E / 49.9878°N 8.2713°E / 49.9878; 8.2713

February 16, 2024
biontech, short, biopharmaceutical, technologies, german, biotechnology, company, based, mainz, that, develops, manufactures, active, immunotherapies, patient, specific, approaches, treatment, diseases, develops, pharmaceutical, candidates, based, messenger, r. BioNTech SE b iː ˈ ɒ n t ɛ k bee ON tek or b aɪ ˈ ɒ n t ɛ k bye ON tek 2 short for Biopharmaceutical New Technologies is a German biotechnology company based in Mainz that develops and manufactures active immunotherapies for patient specific approaches to the treatment of diseases It develops pharmaceutical candidates based on messenger ribonucleic acid mRNA for use as individualized cancer immunotherapies as vaccines against infectious diseases and as protein replacement therapies for rare diseases and also engineered cell therapy novel antibodies and small molecule immunomodulators as treatment options for cancer BioNTech SEHeadquarters in MainzCompany typePublicTraded asNasdaq BNTXISINUS09075V1026IndustryBiotechnologyFounded2008 16 years ago 2008 FoundersUgur SahinOzlem TureciChristoph HuberAndreas StrungmannThomas StrungmannMichael MotschmannHelmut JeggleHeadquartersMainz GermanyNumber of locations8 2022 Area servedWorldwideKey peopleUgur Sahin CEO Ozlem Tureci CMO Sean Marett CBO CCO Sierk Poetting CF COO Ryan Richardson CSO ProductsBNT162b2ServicesImmunotherapyRevenue 17 3 billion 2022 Operating income 12 6 billion 2022 Net income 9 43 billion 2022 Total assets 23 3 billion 2022 Total equity 20 1 billion 2022 Number of employees4 530 2022 Websitebiontech wbr comFootnotes referencesBiontech FY 2022 report 1 The company has developed an mRNA based human therapeutic for intravenous administration to bring individualized mRNA based cancer immunotherapy to clinical trials and to establish its own manufacturing process 3 In 2020 BioNTech partnering with Pfizer for testing and logistics developed the RNA vaccine BNT162b2 for preventing COVID 19 infections which at the time offered a 91 efficacy 4 in preventing confirmed COVID 19 occurring at least 7 days after the second dose of vaccine 5 On 2 December 2020 temporary HMR authorization was granted by the United Kingdom government for BNT162b2 vaccinations within the United Kingdom 6 7 It was the first mRNA vaccine ever authorized Some days later the vaccine also received an emergency approval in the United States 8 Canada 9 and Switzerland 10 On 21 December 2020 the European Commission approved BioNTech Pfizer s coronavirus vaccine in accordance with the positive recommendation of the European Medicines Agency EMA 11 Contents 1 History 1 1 Foundation 2008 2013 1 2 Expansion 2014 2019 1 3 Nasdaq IPO 2019 to COVID 19 2 Corporate affairs 2 1 Locations 2 2 Financing 3 Business activities 3 1 Vaccine development 3 2 Vaccine distribution timeline 3 3 Cancer immunotherapy 4 Sponsorship 5 See also 6 References 7 External linksHistory editFoundation 2008 2013 edit BioNTech was founded in 2008 based on research by Ugur Sahin Ozlem Tureci 12 and Christoph Huber 13 with a seed investment of 150 million from MIG Capital and AT Impf 14 The company s activities focus on the development and production of technologies and drugs for individualized cancer immunotherapy 3 Andreas and Thomas Strungmann Michael Motschmann and Helmut Jeggle were cofounders 15 In 2009 the acquisition of EUFETS and JPT Peptide Technologies took place 16 17 Hungarian biochemist Katalin Kariko whose work on mRNA whilst working at the University of Pennsylvania underpinned the development of Pfizer BioNTech COVID 19 vaccine 18 and who later shared the 2023 Nobel Prize in Physiology or Medicine 19 joined BioNTech as a senior vice president in 2013 20 Expansion 2014 2019 edit Between 2014 and 2018 many research results on mRNA mechanisms were published by BioNTech 21 Collaborations and commercialization programs were concluded with various companies and scientific institutions starting in 2015 22 During this period BioNTech filed several patent applications and developed a multi layered strategy to protect its intellectual property in the various technology platforms and their application in the treatment of cancer and other serious diseases citation needed In August 2018 the company entered into a multi year research and development R amp D collaboration with the US company Pfizer Inc to develop mRNA based vaccines for prevention of influenza Under the terms of the agreement following BioNTech s completion of a first in human clinical study Pfizer would assume sole responsibility for further clinical development and commercialization of mRNA based flu vaccines 23 In January 2019 Sanofi invested 80 million in BioNTech and extended the mRNA cancer research collaboration between the two companies Sanofi previously paid US 60 million upfront for the rights to five discovery stage immunotherapies of BioNTech in 2015 24 In July 2019 Fidelity Management amp Research Company led a Series B investment round totalling 325 million with additional investments from Redmile Group Invus Mirae Asset Financial Group Platinum Asset Management Jebsen Capital Steam Athena Capital BioVeda China Fund and the Struengmann Family Office 25 26 In September 2019 BioNTech received a capital contribution of US 55 million from the Bill amp Melinda Gates Foundation with the option of doubling that investment amount at a later date 27 Nasdaq IPO 2019 to COVID 19 edit Since 10 October 2019 BioNTech with its newly founded North American headquarters in Cambridge Massachusetts has been publicly traded as American Depository Shares ADS on the NASDAQ Global Select Market under the ticker symbol BNTX 28 BioNTech was able to generate total gross proceeds of 150 million dollars from the IPO 29 In 2021 BioNTech announced it would open its Asia headquarters in Singapore and also open a vaccine manufacturing plant there with support from the Singapore Economic Development Board 30 The Singapore factory is expected to be operational by 2023 and produce hundreds of millions of doses of mRNA vaccines per year 31 A collaboration with Fosun Pharma is planned to add a facility in China to produce a billion doses per year for China Macau Hong Kong and Taiwan though as of August 2021 the PRC had not approved any foreign developed COVID 19 vaccines 31 In July 2023 BioNTech acquired the British startup Instadeep for 562 million 682 million in order to expand its activities in the area of artificial intelligence for drug discovery design and development 32 33 Corporate affairs editLocations edit nbsp nbsp Mainz nbsp Idar Oberstein nbsp Martinsried nbsp Neuried nbsp Berlin nbsp Marburgclass notpageimage Locations of BioNTech in Germany The other two are in the United States BioNTech s founding place and global headquarters is Mainz Germany where the COVID 19 vaccine was created The company runs multiple sites in the country Further research locations are in San Diego and Cambridge Massachusetts the latter of which also serves as the North American headquarters Additionally the company owns GMP certified production facilities in Idar Oberstein Martinsried Neuried Bavaria and Berlin In November 2020 the company acquired facilities from Novartis in Marburg to ramp up its vaccine production 34 35 Financing edit In December 2019 BioNTech received a 50 million loan to finance the development of its patient specific immunotherapies for the treatment of cancer and other serious diseases from the European Investment Bank EIB as part of the European Commission Investment Plan for Europe 36 The EIB then signed a 100 million loan in June 2020 after an accelerated approval two months for a process that usually takes more than a year This financing helped BioNTech s vaccine trials and manufacturing The EIB loan is part of the InnovFin Corporate Research Equity programme and the European Fund for Strategic Investments This programme supports innovative and higher risk projects backed by the European Investment Bank with a guarantee from the European Union budget 37 38 39 40 On 17 March 2020 BioNTech received a 135 million investment from Fosun Pharma in exchange for 1 58 million shares in BioNTech and the future development and marketing rights of the mRNA vaccine BNT162b2 in China 41 In June 2020 BioNTech received 250 million from Temasek Holdings Singapore via the purchase of ordinary shares and 4 years convertible notes but also from other investors through a private placement of mandatory convertible bonds 42 On 15 September 2020 the German Federal Ministry of Education and Research BMBF awarded a 375 million grant to BioNTech to accelerate the development of the COVID 19 vaccine 43 Business activities editVaccine development edit See also Pfizer BioNTech COVID 19 vaccine and COVID 19 vaccine Clinical trials started in 2020 nbsp Pfizer BioNTech COVID 19 vaccine Project Lightspeed the project to develop a novel mRNA technology for a COVID 19 vaccine began in mid January 2020 just days after the SARS Cov 2 genetic sequence was first made public 44 The company is partnered on this project with Pfizer 45 and Fosun 46 47 The production of the vaccine was followed by clinical trials the success of which was a prerequisite for the commencement of marketing On 9 November 2020 BioNTech and Pfizer announced that 43 500 people in 6 countries had received a test vaccine against COVID 19 with more than 90 percent effectiveness On the basis of successful testing they asked for the right to distribute vaccines in the United States as well as in the European Union the United Kingdom and Japan 48 Vaccine distribution timeline edit In July 2020 BioNTech and pharmaceutical corporation Pfizer signed contracts to supply 120 million doses for Japan 100 million doses for the United States at 19 50 and 40 million doses for the United Kingdom if proven effective safe and licensed 49 50 51 52 On 5 August 2020 Canada pre ordered 20 million doses of the vaccine 53 In September 2020 Germany privately ordered 30 million doses outside the collective EU purchasing scheme 54 On 5 November 2020 Australia pre ordered 10 million doses 55 On 9 November 2020 BioNTech Pfizer released a positive interim analysis of a Phase III clinical trial in the United States On 10 November 2020 BioNTech and Pfizer applied for an emergency use authorization EUA with the FDA which was reviewed by mid December 56 57 The FDA released a document explaining that an EUA is a mechanism to facilitate the availability and use of medical countermeasures including vaccines during public health emergencies such as the current COVID 19 pandemic 58 On 11 November 2020 the European Union pre ordered 300 million doses at an initial price of 12 per dose Under the agreement the vaccine producing pair BioNTech and Pfizer are subject to a tightened legal obligation to bring all the experience they have gained to the EMA for review 59 60 Belgium s budget state secretary Eva De Bleeker accidentally revealed the vaccine purchase price per dose agreed by the EU with various companies with Oxford AstraZeneca at 1 78 Johnson amp Johnson at 8 50 Sanofi GSK at 7 56 CureVac at 10 and Moderna at 18 61 In the same month Israel ordered 8 million doses at 23 50 a dose 62 63 In the same month BioNTech Pfizer submitted an EUA application in Canada 64 On 2 December 2020 the United Kingdom granted conditional temporary authorization under Regulation 174 of the Human Medicines Regulations 2012 for BNT162b2 6 becoming the first country to approve an mRNA vaccine and the first Western country to approve a COVID 19 vaccine for national use 7 65 In the same month BNT162b2 was revealed to also be under evaluation for EUA status in several other countries 66 On 15 December 2020 Fosun Pharma agreed a deal to deliver 100 million doses of the BioNTech Pfizer vaccine to China 67 with Hong Kong securing 7 5 million doses On 21 December 2020 the European Medicines Agency EMA authorised a one year conditional use of the BioNTech Pfizer vaccine in the European Union Emer Cooke Director of the EMA stated that the benefits of the vaccine far outweigh the potential risks 68 On 26 December 2020 following the authorisation initial mass vaccination against coronavirus commenced in Hungary and Slovakia 69 On 8 January 2021 the European Union ordered an additional 200 million doses of the vaccine with an option for 100 million more 70 On 25 June 2021 the US Food and Drug Administration FDA added a warning about the risk of rare heart inflammation myocarditis to the specifications of both Pfizer BioNTech and Moderna vaccines As of that date there were already 138 million US citizens who had been vaccinated twice with one of the mRNA based vaccines according to the US Centers for Disease Control and Prevention CDC 71 72 Cancer immunotherapy edit In early 2023 BioNTech started a series of clinical trials in the United Kingdom for mRNA based immunotherapies targeting several types of cancer 73 In November 2023 in an interview to German broadcaster ZDF BioNTech CEO Ugur Sahin said the company expects a mRNA based therapeutic cancer vaccine approval by 2030 74 Sponsorship editBioNTech together with Pfizer co sponsored the Academy Awards ceremony in March 2022 as main sponsors 75 In the sponsorship the pharmaceutical duo stated that the widespread use of their vaccines and booster shots has helped prevent Covid19 diseases and protect lives and the film industry has partnered to promote vaccines mask use and other prevention strategies BioNTech s spectacular marketing promotional success in the 2022 Oscars sponsorship was its ability to appear ahead of its huge pharma partner Pfizer in the promotional duo s ubiquitous roster This was a significant achievement because by this time BioNTech had been removed from the name of the vaccine in almost every language in the world and their joint product was mostly referred to simply as Pfizer 76 See also editBBV152 CureVac Moderna COVID 19 vaccine Novavax COVID 19 vaccine Oxford AstraZeneca COVID 19 vaccine Sputnik V COVID 19 vaccine V451 vaccineReferences edit BioNTech 2022 Annual Report Form 20 F U S Securities and Exchange Commission 27 March 2023 Retrieved 24 June 2023 BioNTech CEO on vaccine progress with Pfizer YouTube Retrieved 14 June 2021 via YouTube a b BioNTech SE 9 September 2019 Form F 1 U S Securities and Exchange Commission archived from the original on 14 February 2021 retrieved 23 September 2020 Commissioner Office of the 23 August 2021 FDA Approves First COVID 19 Vaccine FDA Retrieved 3 November 2021 Vaccines and Related Biological Products Advisory Committee Meeting December 10 2020 FDA Briefing Document Pfizer BioNTech COVID 19 Vaccine Report Retrieved 4 July 2021 a b Conditions of Authorisation for Pfizer BioNTech COVID 19 vaccine PDF Government of the United Kingdom 2 December 2020 Retrieved 2 December 2020 a b UK medicines regulator gives approval for first UK COVID 19 vaccine Government of the United Kingdom 2 December 2020 Retrieved 2 December 2020 Pfizer BioNTech COVID 19 Vaccine Frequently Asked Questions retrieved 22 December 2020 Pfizer BioNTech COVID 19 vaccine What you should know 9 December 2020 retrieved 22 December 2020 Swissmedic grants authorisation for the first COVID 19 vaccine in Switzerland retrieved 22 December 2020 Commission approves BioNTech Pfizer vaccine Politico 21 December 2020 Retrieved 22 December 2020 BioNTech s founders scientist couple in global spotlight France 24 13 November 2020 Retrieved 22 December 2020 Prof Christopher Huber Biontech Biography Biontech Retrieved 5 August 2021 SEC Filing BioNTech investors biontech de p 130 Retrieved 28 December 2020 BioNTech s founders scientist couple in global spotlight France 24 13 November 2020 Retrieved 7 December 2020 Eufets Becomes BioNTech Innovative Manufacturing Services BioNTech IMFS 18 September 2017 retrieved 11 November 2020 TheraCode to Acquire JPT Peptide Technologies GenomeWeb 11 May 2009 Retrieved 7 December 2020 The story of mRNA From a loose idea to a tool that may help curb Covid STAT 10 November 2020 Retrieved 19 June 2021 Mole Beth 2 October 2023 After being demoted and forced to retire mRNA researcher wins Nobel Ars Technica Retrieved 3 October 2023 Magyar kutato hanyatatott sorsu szabadalma is kellett a most bejelentett vakcinahoz Hungarian researcher he also had to have a patent with a significant implication for the vaccine just announced forbes hu in Hungarian 9 November 2020 Archived from the original on 26 January 2021 Retrieved 22 December 2020 Kranz Lena M Diken Mustafa Haas Heinrich Kreiter Sebastian Loquai Carmen 16 June 2016 Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy Nature vol 534 no 7607 pp 396 401 Bibcode 2016Natur 534 396K doi 10 1038 nature18300 ISSN 1476 4687 PMID 27281205 S2CID 38112227 retrieved 11 November 2020 Taylor Nick Paul 21 September 2016 Genentech lays 310M wager on BioNTech s mRNA cancer vaccine platform FierceBiotech Retrieved 7 December 2020 Maas Sylke Woolford John Alatovic Jasmina 16 August 2018 BioNTech Signs Collaboration Agreement with Pfizer to Develop mRNA based Vaccines for Prevention of Influenza BioNTech Archived from the original on 8 December 2021 Retrieved 28 December 2022 Sanofi invests 80M in BioNTech as cancer mRNA hits clinic Fierce Pharma 4 January 2019 Retrieved 4 November 2021 Taylor Nick Paul 9 July 2019 BioNTech raises 325M series B round to advance cancer pipeline Fierce Biotech Archived from the original on 28 December 2022 Retrieved 28 December 2022 Keown Callum Saigol Lina 8 December 2020 Here are 5 things to know about BioNTech and the married couple behind the COVID 19 vaccine developed with Pfizer MarketWatch Archived from the original on 29 December 2022 Retrieved 29 December 2022 BioNTech Announces New Collaboration to Develop HIV and Tuberculosis Programs BioNTech 4 September 2019 Retrieved 27 December 2020 BioNTech SE NASDAQ retrieved 12 November 2020 Spalding Rebecca Franklin Joshua 9 October 2019 Germany s BioNTech raises 150 million in smaller than planned U S IPO amid market volatility Reuters Retrieved 7 December 2020 BioNTech to produce vaccines in Singapore its new regional headquarters 10 May 2021 www cnbc com accessed 16 October 2022 a b BioNTech to build mRNA vaccine manufacturing site in Singapore 10 May 2021 www metro us accessed 16 October 2022 BioNTech Completes Acquisition of InstaDeep Yahoo Finance Press release 31 July 2023 Retrieved 1 August 2023 Burger Ludwig Jain Pratik Leo Leroy 10 January 2023 Germany s BioNTech buys British AI startup InstaDeep Reuters BioNTech locations biontech de accessed 16 October 2022 BioNTech buys German site from Novartis to boost vaccine output Reuters 17 September 2020 European Investment Bank provides funding of 50 million to BioNTech as part of the Investment Plan for Europe European Commission 17 December 2019 Retrieved 21 November 2020 BioNTech moves to head of pack for COVID 19 vaccine with EU finance European Investment Bank Retrieved 30 June 2021 EU forks out 50 million to clean Internet Network Security 2004 3 3 March 2004 doi 10 1016 s1353 4858 04 00047 9 ISSN 1353 4858 BioNTech moves to head of pack for COVID 19 vaccine with EU finance European Investment Bank Retrieved 3 February 2021 Investment Plan for Europe European Investment Bank to provide BioNTech with up to 100 million in debt financing for COVID 19 vaccine development and manufacturing European Commission 11 June 2020 Retrieved 21 November 2020 Burger Ludwig 15 March 2020 BioNTech in China alliance with Fosun over coronavirus vaccine candidate Reuters Retrieved 22 July 2021 Burger Ludwig 29 June 2020 Temasek led investor group in 250 million vaccine bet on Germany s BioNTech Reuters Frankfurt Retrieved 2 August 2020 SE BioNTech 15 September 2020 BioNTech to Receive up to 375M in Funding from German Federal Ministry of Education and Research to Support COVID 19 Vaccine Program BNT162 GlobeNewswire News Room Retrieved 3 February 2021 Aiming to address the global coronavirus pandemic Project Lightspeed BioNTech 2020 Retrieved 13 December 2020 Lovelace Jr Berkeley 27 July 2020 Pfizer and BioNTech began late stage human trial for coronavirus vaccine Monday CNBC Retrieved 2 August 2020 BioNTech in China alliance with Fosun over coronavirus vaccine candidate Reuters Frankfurt 15 March 2020 Retrieved 2 August 2020 Burger Ludwig 22 April 2020 Germany approves trials of COVID 19 vaccine candidate Reuters Berlin Retrieved 2 August 2020 Covid vaccine First milestone vaccine offers 90 protection BBC News 9 November 2020 Retrieved 22 December 2020 Shakil Ismail Mishra Manas 31 July 2020 Pfizer BioNTech to supply 120 million doses of coronavirus vaccine to Japan Reuters Bengaluru Retrieved 3 August 2020 Erman Michael Banerjee Ankur 22 July 2020 U S to pay Pfizer BioNTech 1 95 billion for COVID 19 vaccine Reuters Retrieved 2 August 2020 Gallagher James 20 July 2020 Coronavirus vaccine UK government signs deals for 90 million doses BBC News Retrieved 2 August 2020 Smout Alistair 20 July 2020 Britain secures 90 million possible COVID 19 vaccine doses from Pfizer BioNTech Valneva Reuters London Retrieved 2 August 2020 SE BioNTech 5 August 2020 Pfizer and BioNTech to Supply Canada with their BNT162 mRNA Based Vaccine Candidate GlobeNewswire News Room Retrieved 3 February 2021 Fortuna Gerardo 8 January 2021 Commission takes evasive action over Germany s vaccine side deal euractiv com Retrieved 3 February 2021 Australia Secures a further 50 Million Doses of COVID 19 Vaccine Prime Minister of Australia www pm gov au Retrieved 3 February 2021 Coronavirus COVID 19 Update FDA Announces Advisory Committee Meeting to Discuss COVID 19 Vaccine Candidate U S Food and Drug Administration FDA Press release Retrieved 20 November 2020 nbsp This article incorporates text from this source which is in the public domain Helen Branswell 20 November 2020 Pfizer BioNTech submit formal application to FDA to authorize Covid 19 vaccine STAT Retrieved 25 November 2020 Emergency Use Authorization for Vaccines Explained U S Food and Drug Administration 20 November 2020 Retrieved 20 November 2020 nbsp This article incorporates text from this source which is in the public domain Coronavirus EU buys 300m doses of BioNTech Pfizer vaccine BBC News United Kingdom 11 November 2020 Retrieved 12 November 2020 Az Europai Gyogyszerugynokseg forgalmazasra ajanlja a Pfizer BioNTech vakcinat koronavirus gov hu in Hungarian 21 December 2020 Retrieved 22 December 2020 Belgian secretary of state accidentally reveals EU vaccine prices Politico 17 December 2020 Retrieved 22 December 2020 Israel receives initial shipment of Pfizer coronavirus vaccine CNBC 9 December 2020 Retrieved 3 February 2021 Dyer Owen 29 January 2021 Covid 19 Countries are learning what others paid for vaccines BMJ 372 n281 doi 10 1136 bmj n281 ISSN 1756 1833 PMID 33514535 Katie Dangerfield 20 November 2020 Pfizer files for emergency use of coronavirus vaccine in U S what about in Canada Global News Retrieved 25 November 2020 Roberts Michelle 2 December 2020 Covid Pfizer vaccine approved for use next week in UK BBC Retrieved 2 December 2020 Benjamin Mueller 2 December 2020 U K Approves Pfizer coronavirus vaccine a first in the West The New York Times Retrieved 2 December 2020 Fosun Pharma to buy 100 million doses of BioNTech s COVID 19 vaccine for mainland China Reuters 16 December 2020 Retrieved 3 February 2021 EMA recommends first COVID 19 vaccine for authorisation in the EU European Medicines Agency 21 December 2020 Retrieved 9 February 2021 Binnie Anita Komuves Benoit Van Overstraeten Isla 27 December 2020 Window of hope Europe begins to launch COVID 19 vaccinations Reuters Retrieved 27 December 2020 a href Template Cite news html title Template Cite news cite news a CS1 maint multiple names authors list link Welle www dw com Deutsche 8 January 2021 COVID vaccine EU orders 300 million more BioNTech Pfizer doses Deutsche Welle Retrieved 3 February 2021 Commissioner Office of the 25 June 2021 Coronavirus COVID 19 Update June 25 2021 FDA Retrieved 30 June 2021 FDA adds warning about rare heart inflammation to Pfizer Moderna COVID shots Reuters 26 June 2021 Retrieved 30 June 2021 UK BioNTech test mRNA against cancer Nature Biotechnology 41 2 162 15 February 2023 doi 10 1038 s41587 023 01693 z PMID 36792707 S2CID 256875318 Krebs Impfstoffe Biontech plant Therapieansatz vor 2030 ZDFheute in German Retrieved 26 November 2023 Pfizer und BioNTech bei der Oscar Verleihung Pfizer and BioNTech at the Oscars ePharmaINSIDER 6 April 2022 Retrieved 27 May 2022 Adams Ben 28 March 2022 Pfizer and BioNTech go to Hollywood with splashy Oscars sponsorship Fierce Pharma Retrieved 27 May 2022 External links edit nbsp Wikimedia Commons has media related to BioNTech nbsp Scholia has a profile for BioNTech Q30256699 Official website nbsp Business data for BioNTech BloombergGoogleReutersSEC filingsYahoo 49 59 16 N 8 16 17 E 49 9878 N 8 2713 E 49 9878 8 2713 Retrieved from https en wikipedia org w index php title BioNTech amp oldid 1207409472, wikipedia, wiki, book, books, library,

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