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Stephen Elledge

April 12, 2024

Stephen Joseph Elledge (born August 7, 1956) is an American geneticist. He is the current Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital.[3][4] His research is focused on the genetic and molecular mechanisms of eukaryotic response to DNA damage and is known as the discoverer of the DNA damage response (DDR).

Stephen Joseph Elledge[1]
Born (1956-08-07) August 7, 1956 (age 67)[2]
Paris, Illinois[2]
NationalityAmerican
EducationUniversity of Illinois Urbana-Champaign (BSc)
Massachusetts Institute of Technology (PhD)
Known forCell cycle research
DNA repair research
SpouseMitzi Kuroda
AwardsNAS Award in Molecular Biology
Breakthrough Prize in Life Sciences
Genetics Society of America Medal
Dickson Prize
Canada Gairdner International Award
Albert Lasker Award for Basic Medical Research
Gruber Prize in Genetics
Scientific career
FieldsGenetics
Molecular biology
InstitutionsHarvard University
Brigham and Women's Hospital
Baylor College of Medicine
Howard Hughes Medical Institute
Stanford University
ThesisIdentification and characterization of genes involved in mutagenesis in Escherichia coli (1983)
Doctoral advisorGraham C. Walker

Early life and education edit

Elledge was born in Paris, Illinois in 1956.[2] He also grew in up, graduating from Paris High School in 1974. He has been interested in chemistry since childhood, thanks to a chemistry set his grandmother gave him.[5]

He entered the University of Illinois Urbana-Champaign, majoring in chemistry and hoping to become an organic chemist.[6] Elledge initially ignored life science subjects, until he attended biology and genetics courses on exchange to the University of Southampton, England, during his third (or junior) year. He took biochemistry courses after returning to Illinois,[7] which prompted him to study PhD in biology at the Massachusetts Institute of Technology (MIT) after obtaining his BSc in 1978.[8] Elledge graduated from MIT in 1983.[2]

Career edit

Elledge started his career as a postdoctoral fellow at Stanford University in 1984 in Ronald W. Davis's group.[8] In 1989, he moved to the Baylor College of Medicine as an assistant professor in biochemistry,[9] He was promoted to associate professor in 1993 and full professor in 1995.[2]

In 2003, Elledge joined the Department of Genetics of Harvard Medical School.[10][11]

Currently, Elledge is the Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital.[3][12] He also sits on the Board of Advisory Scientists of the Whitehead Institute[13] and the advisory board of Molecular Cell.[14]

Elledge has been an investigator at the Howard Hughes Medical Institute since 1993.[15]

Research edit

Elledge's research spans multiple areas, including cell cycle, DNA repair, and detection of virus from blood.

He began studying DNA repair during his years at Stanford University as a postdoctoral fellow. Elledge accidentally[16] discovered the RNR2 gene and protein in yeast, which belongs to the family of ribonucleotide reductase, and found that its expression increases when DNA is damaged.[17] The human counterparts of RNR2, or homologs, are RRM2 and RRM2B.[18]

Over the next decade, he continued the search for genes and proteins involved in the DNA damage response pathway in yeasts and humans. Examples include DUN1,[19] MEC1, and TEL1 in yeasts,[20] (respective human homologs are CHEK2, ATR, and ATM) and CHEK1[21] and CHEK2[22] in humans.

In cell cycle research, his group published two important papers on cell cycle checkpoints in 1993. In parallel and independently from Bert Vogelstein's group, he discovered and characterized p21, a cyclin-dependent kinase inhibitor protein that blocks G1/S transition.[23] He also showed that the Rb protein physically associates with PP1a from mitosis until mid-G1 phase in yeasts.[24] After moving to the Baylor College of Medicine, Elledge reported his identification of CDK2, a protein whose activation allows cells to transit from the G1 phase into the S phase of the cell cycle.[25]

Elledge's group also discovered the F-box protein structural motif, and found that it recognizes specific protein sequences and tags the proteins with ubiquitin for degradation.[26] He correctly predicted the central role of F-Box in protein degradation due to the large number of proteins having this motif.[27]

In 2015, Elledge's group developed VirScan, a platform that detects viral infection in patients from a small amount of blood.[28][29][30]

In recent years, Elledge has continued to expand his research area. For instance, his group reported a computational model that predicted the likelihood of regions on the chromosome to be abnormally amplified.[31][32]

During the COVID-19 pandemic, Elledge estimated that United States has lost a total of 2.5 million years of life.[33][34][35][36]

Personal life edit

Elledge was married to Mitzi Kuroda,[37] herself a professor at the Department of Genetics at Harvard Medical School.[38] They both moved from Baylor College of Medicine to Harvard Medical School in 2003.[39]

Awards edit

References edit

  1. ^ a b . Gairdner Foundation. Archived from the original on May 28, 2022. Retrieved May 28, 2022.
  2. ^ a b c d e . Science History Institute. August 18, 1995. Archived from the original on March 15, 2023. Retrieved March 15, 2023.
  3. ^ a b . Harvard Medical School. February 10, 2023. Archived from the original on March 21, 2023. Retrieved March 21, 2023.
  4. ^ . Harvard Medical School. Archived from the original on March 17, 2023. Retrieved March 17, 2023.
  5. ^ Loughlin, Sue (December 23, 2016). . Tribune-Star. Archived from the original on March 16, 2023. Retrieved March 16, 2023.
  6. ^ Nadis, Steve. . Discover. Archived from the original on December 12, 2016. Retrieved December 16, 2016.
  7. ^ Howard, Joy. . Brigham Health. No. Summer 2017. Brigham and Women’s Hospital. Archived from the original on March 25, 2023. Retrieved March 25, 2023.
  8. ^ a b Brownlee, Christen (2004). "Biography of Stephen J. Elledge". Proceedings of the National Academy of Sciences. 101 (10): 3336–3337. doi:10.1073/pnas.0400868101. PMC 373462. PMID 14993590.
  9. ^ Rogers, Kara (August 3, 2022). "Stephen J. Elledge". Encyclopædia Britannica. Retrieved March 23, 2023.{{cite web}}: CS1 maint: date and year (link)
  10. ^ Azvolinsky, Anna (September 30, 2017). . The Scientist. No. October 2017. Archived from the original on July 26, 2020. Retrieved July 26, 2020.
  11. ^ Peterson, Doug (November 1, 2013). . College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign. Archived from the original on August 9, 2022. Retrieved August 9, 2022.
  12. ^ . Brigham and Women's Hospital. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  13. ^ . Whitehead Institute. Archived from the original on March 27, 2023. Retrieved March 27, 2023.
  14. ^ . Molecular Cell. Archived from the original on March 27, 2023. Retrieved March 27, 2023.
  15. ^ . Howard Hughes Medical Institute. Archived from the original on March 15, 2023. Retrieved March 15, 2023.
  16. ^ Elledge, Stephen J. (2015). "Accidents and Damage Control". Cell. 162 (6): 1196–1200. doi:10.1016/j.cell.2015.08.042. PMID 26359977.
  17. ^ Elledge, S. J.; Davis, R. W. (1987). "Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability". Molecular and Cellular Biology. 7 (8): 2783–2793. doi:10.1128/mcb.7.8.2783-2793.1987. PMC 367895. PMID 3313004.
  18. ^ "RNR2 ribonucleotide-diphosphate reductase subunit RNR2 [ Saccharomyces cerevisiae S288C ]". National Center for Biotechnology Information. March 10, 2023. Archived from the original on March 29, 2023. Retrieved March 29, 2023.
  19. ^ Zhou, Zheng; Elledge, Stephen J. (1993). "DUN1 encodes a protein kinase that controls the DNA damage response in yeast". Cell. 75 (6): 1119–1127. doi:10.1016/0092-8674(93)90321-g. PMID 8261511. S2CID 6606697. Retrieved April 3, 2023.
  20. ^ Sanchez, Yolanda; Desany, Brian A.; Jones, William J.; Liu, Qinghua; Wang, Bin; Elledge, Stephen J. (1996). "Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways". Science. 271 (5247): 357–360. Bibcode:1996Sci...271..357S. doi:10.1126/science.271.5247.357. PMID 8553072. S2CID 21223989. Retrieved April 3, 2023.
  21. ^ Sanchez, Yolanda; Wong, Calvin; Thoma, Richard S.; Richman, Ron; Wu, Zhiqi; Piwnica-Worms, Helen; Elledge, Stephen J. (1997). "Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25". Science. 277 (5331): 1497–1501. doi:10.1126/science.277.5331.1497. PMID 9278511. Retrieved April 3, 2023.
  22. ^ Matsuoka, Shuhei; Huang, Mingxia; Elledge, Stephen J. (1998). "Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase". Science. 282 (5395): 1893–1897. Bibcode:1998Sci...282.1893M. doi:10.1126/science.282.5395.1893. PMID 9836640. Retrieved April 3, 2023.
  23. ^ Harper, J. Wade; Adami, Guy R.; Wei, Nan; Keyomarsi, Khandan; Elledge, Stephen J. (1993). (PDF). Cell. 75 (4): 805–816. doi:10.1016/0092-8674(93)90499-g. PMID 8242751. S2CID 13614794. Archived from the original (PDF) on April 1, 2023. Retrieved April 1, 2023.
  24. ^ Durfee, Tim; Becherer, Kathleen; Chen, Phang-Lang; Yeh, Shiou-Hwei; Yang, Yanzhu; Kilburn, April E.; Lee, Wen-Hwa; Elledge, Stephen J. (1993). (PDF). Genes & Development. 7 (9): 555–569. doi:10.1101/gad.7.4.555. PMID 8384581. S2CID 23631016. Archived from the original (PDF) on April 1, 2023. Retrieved April 1, 2023.
  25. ^ Elledge, S.J.; Spottswood, M.R. (1991). "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1". EMBO Journal. 10 (9): 2653–2659. doi:10.1002/j.1460-2075.1991.tb07808.x. PMC 452966. PMID 1714386.
  26. ^ Bai, Chang; Sen, Partha; Hofmann, Kay; Ma, Lei; Goebl, Mark; Harper, J. Wade; Elledge, Stephen J. (1996). "SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box". Cell. 86 (2): 263–274. doi:10.1016/s0092-8674(00)80098-7. PMID 8706131.
  27. ^ Kipreos, Edward T.; Pagano, Michele (2000). "The F-box protein family". Genome Biology. 1 (5): reviews3002.1. doi:10.1186/gb-2000-1-5-reviews3002. PMC 138887. PMID 11178263.
  28. ^ Xu, George J.; Kula, Tomasz; Xu, Qikai; Li, Mamie Z.; Vernon, Suzanne D.; Ndung’u, Thumbi; Ruxrungtham, Kiat; Sanchez, Jorge; Brander, Christian; Chung, Raymond T.; O’Connor, Kevin C.; Walker, Bruce; Larman, H. Benjamin; Elledge, Stephen J. (2015). "Comprehensive serological profiling of human populations using a synthetic human virome". Science. 348 (6299): aaa0698. doi:10.1126/science.aaa0698. PMC 4844011. PMID 26045439.
  29. ^ Abbas, Anzar. . HHMI Bulletin. Vol. 28, no. 3. Howard Hughes Medical Institute. Archived from the original on April 3, 2023. Retrieved April 5, 2023.
  30. ^ Bridger, Haley (June 4, 2015). . Harvard Medical School. Archived from the original on April 5, 2023. Retrieved April 5, 2023.
  31. ^ Davoli, Teresa; Xu, Andrew Wei; Mengwasser, Kristen E.; Sack, Laura M.; Yoon, John C.; Park, Peter J.; Elledge, Stephen J. (2013). "Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome". Cell. 155 (4): 948–962. doi:10.1016/j.cell.2013.10.011. PMC 3891052. PMID 24183448.
  32. ^ Null (January 30, 2017). . Proceedings of the National Academy of Sciences. Archived from the original on April 6, 2023. Retrieved April 6, 2023.
  33. ^ Elledge, Stephen J. (October 27, 2020). "2.5 Million Person-Years of Life Have Been Lost Due to COVID-19 in the United States". medRxiv 10.1101/2020.10.18.20214783.
  34. ^ Weintraub, Karen (October 20, 2020). . USA Today. Archived from the original on March 25, 2023. Retrieved March 23, 2023.
  35. ^ Deese, Kaelan (October 21, 2020). . The Hill. Archived from the original on March 25, 2023. Retrieved March 23, 2023.
  36. ^ Wu, Katherine J. (October 21, 2020). . The New York Times. Archived from the original on December 31, 2022. Retrieved December 31, 2022.
  37. ^ a b . Gruber Foundation. Archived from the original on March 17, 2023. Retrieved March 17, 2023.
  38. ^ Department of Genetics, Harvard Medical School. November 2021. Archived from the original on March 17, 2023. Retrieved March 17, 2023.
  39. ^ "Movers". Nature. 423 (6938): 464. 2003. Bibcode:2003Natur.423..464.. doi:10.1038/nj6938-464a.
  40. ^ . Memorial Sloan Kettering Cancer Center. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  41. ^ . National Academy of Sciences. Archived from the original on March 18, 2023. Retrieved March 18, 2023.
  42. ^ . National Academy of Sciences. Archived from the original on March 18, 2023. Retrieved March 18, 2023.
  43. ^ . American Academy of Arts and Sciences. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  44. ^ . Hans Sigrist Foundation. October 15, 2021. Archived from the original on March 14, 2023. Retrieved March 14, 2023.
  45. ^ Haber, James E. (2005). . Genetics. 169 (2): 506–507. doi:10.1093/genetics/169.2.506. PMC 1449134. PMID 15731513. Archived from the original on March 18, 2023. Retrieved March 18, 2023.
  46. ^ a b . American Association for Cancer Research. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  47. ^ National Academy of Medicine. Archived from the original on March 20, 2023. Retrieved March 20, 2023.
  48. ^ . Dickson Prize in Medicine. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  49. ^ . Brandeis University. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  50. ^ . Lasker Award. Archived from the original on March 19, 2023. Retrieved March 19, 2023.
  51. ^ . Breakthrough Prize. Archived from the original on March 17, 2023. Retrieved March 17, 2023.
  52. ^ . University of Illinois Alumni Association. June 22, 2017. Archived from the original on March 23, 2023. Retrieved March 23, 2023.
  53. ^ . American Association for the Advancement of Science. Archived from the original on March 20, 2023. Retrieved March 20, 2023.

External links edit

  • His academic home page
  • His Howard Hughes Medical Institute bio
  • Elledge Lab Page

April 12, 2024
stephen, elledge, stephen, joseph, elledge, born, august, 1956, american, geneticist, current, gregor, mendel, professor, genetics, medicine, department, genetics, harvard, medical, school, division, genetics, brigham, women, hospital, research, focused, genet. Stephen Joseph Elledge born August 7 1956 is an American geneticist He is the current Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women s Hospital 3 4 His research is focused on the genetic and molecular mechanisms of eukaryotic response to DNA damage and is known as the discoverer of the DNA damage response DDR Stephen Joseph Elledge 1 Born 1956 08 07 August 7 1956 age 67 2 Paris Illinois 2 NationalityAmericanEducationUniversity of Illinois Urbana Champaign BSc Massachusetts Institute of Technology PhD Known forCell cycle research DNA repair researchSpouseMitzi KurodaAwardsNAS Award in Molecular Biology Breakthrough Prize in Life Sciences Genetics Society of America Medal Dickson Prize Canada Gairdner International Award Albert Lasker Award for Basic Medical Research Gruber Prize in GeneticsScientific careerFieldsGenetics Molecular biologyInstitutionsHarvard University Brigham and Women s Hospital Baylor College of Medicine Howard Hughes Medical Institute Stanford UniversityThesisIdentification and characterization of genes involved in mutagenesis inEscherichia coli 1983 Doctoral advisorGraham C Walker Contents 1 Early life and education 2 Career 3 Research 4 Personal life 5 Awards 6 References 7 External linksEarly life and education editElledge was born in Paris Illinois in 1956 2 He also grew in up graduating from Paris High School in 1974 He has been interested in chemistry since childhood thanks to a chemistry set his grandmother gave him 5 He entered the University of Illinois Urbana Champaign majoring in chemistry and hoping to become an organic chemist 6 Elledge initially ignored life science subjects until he attended biology and genetics courses on exchange to the University of Southampton England during his third or junior year He took biochemistry courses after returning to Illinois 7 which prompted him to study PhD in biology at the Massachusetts Institute of Technology MIT after obtaining his BSc in 1978 8 Elledge graduated from MIT in 1983 2 Career editElledge started his career as a postdoctoral fellow at Stanford University in 1984 in Ronald W Davis s group 8 In 1989 he moved to the Baylor College of Medicine as an assistant professor in biochemistry 9 He was promoted to associate professor in 1993 and full professor in 1995 2 In 2003 Elledge joined the Department of Genetics of Harvard Medical School 10 11 Currently Elledge is the Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women s Hospital 3 12 He also sits on the Board of Advisory Scientists of the Whitehead Institute 13 and the advisory board of Molecular Cell 14 Elledge has been an investigator at the Howard Hughes Medical Institute since 1993 15 Research editElledge s research spans multiple areas including cell cycle DNA repair and detection of virus from blood He began studying DNA repair during his years at Stanford University as a postdoctoral fellow Elledge accidentally 16 discovered the RNR2 gene and protein in yeast which belongs to the family of ribonucleotide reductase and found that its expression increases when DNA is damaged 17 The human counterparts of RNR2 or homologs are RRM2 and RRM2B 18 Over the next decade he continued the search for genes and proteins involved in the DNA damage response pathway in yeasts and humans Examples include DUN1 19 MEC1 and TEL1 in yeasts 20 respective human homologs are CHEK2 ATR and ATM and CHEK1 21 and CHEK2 22 in humans In cell cycle research his group published two important papers on cell cycle checkpoints in 1993 In parallel and independently from Bert Vogelstein s group he discovered and characterized p21 a cyclin dependent kinase inhibitor protein that blocks G1 S transition 23 He also showed that the Rb protein physically associates with PP1a from mitosis until mid G1 phase in yeasts 24 After moving to the Baylor College of Medicine Elledge reported his identification of CDK2 a protein whose activation allows cells to transit from the G1 phase into the S phase of the cell cycle 25 Elledge s group also discovered the F box protein structural motif and found that it recognizes specific protein sequences and tags the proteins with ubiquitin for degradation 26 He correctly predicted the central role of F Box in protein degradation due to the large number of proteins having this motif 27 In 2015 Elledge s group developed VirScan a platform that detects viral infection in patients from a small amount of blood 28 29 30 In recent years Elledge has continued to expand his research area For instance his group reported a computational model that predicted the likelihood of regions on the chromosome to be abnormally amplified 31 32 During the COVID 19 pandemic Elledge estimated that United States has lost a total of 2 5 million years of life 33 34 35 36 Personal life editElledge was married to Mitzi Kuroda 37 herself a professor at the Department of Genetics at Harvard Medical School 38 They both moved from Baylor College of Medicine to Harvard Medical School in 2003 39 Awards editPaul Marks Prize for Cancer Research 2001 40 National Academy of Sciences Award in Molecular Biology 2002 41 Member of the National Academy of Sciences 2003 42 Member of the American Academy of Arts and Sciences 2003 43 Hans Sigrist Prize 2005 44 Genetics Society of America Medal 2005 45 Fellow of the American Academy of Microbiology 2005 46 Member of the Institute of Medicine now National Academy of Medicine 2006 47 Dickson Prize 2010 48 Lewis S Rosenstiel Award 2012 49 Canada Gairdner International Award 2013 1 Fellow of the American Association for Cancer Research Academy 2014 46 Albert Lasker Award for Basic Medical Research 2015 50 Breakthrough Prize in Life Sciences 2016 51 Gruber Prize in Genetics 2017 37 Alumni Award University of Illinois Alumni Association 2017 52 Fellow of the American Association for the Advancement of Science 2018 53 References edit a b Stephen Joseph Elledge Gairdner Foundation Archived from the original on May 28 2022 Retrieved May 28 2022 a b c d e Oral history interview with Stephen J Elledge Science History Institute August 18 1995 Archived from the original on March 15 2023 Retrieved March 15 2023 a b Stephen J Elledge Ph D Harvard Medical School February 10 2023 Archived from the original on March 21 2023 Retrieved March 21 2023 People Harvard Medical School Archived from the original on March 17 2023 Retrieved March 17 2023 Loughlin Sue December 23 2016 Wabash Valley native honored for pioneering research Tribune Star Archived from the original on March 16 2023 Retrieved March 16 2023 Nadis Steve A Drop of Blood a History of Viruses Discover Archived from the original on December 12 2016 Retrieved December 16 2016 Howard Joy Stephen J Elledge PhD Brigham Health No Summer 2017 Brigham and Women s Hospital Archived from the original on March 25 2023 Retrieved March 25 2023 a b Brownlee Christen 2004 Biography of Stephen J Elledge Proceedings of the National Academy of Sciences 101 10 3336 3337 doi 10 1073 pnas 0400868101 PMC 373462 PMID 14993590 Rogers Kara August 3 2022 Stephen J Elledge Encyclopaedia Britannica Retrieved March 23 2023 a href Template Cite web html title Template Cite web cite web a CS1 maint date and year link Azvolinsky Anna September 30 2017 Damage Patroller The Scientist No October 2017 Archived from the original on July 26 2020 Retrieved July 26 2020 Peterson Doug November 1 2013 A Molecular Pathfinder College of Liberal Arts amp Sciences University of Illinois Urbana Champaign Archived from the original on August 9 2022 Retrieved August 9 2022 Genetics Researchers amp Staff Brigham and Women s Hospital Archived from the original on March 19 2023 Retrieved March 19 2023 Board of Advisory Scientists Whitehead Institute Archived from the original on March 27 2023 Retrieved March 27 2023 Advisory board Molecular Cell Archived from the original on March 27 2023 Retrieved March 27 2023 Stephen J Elledge PhD Howard Hughes Medical Institute Archived from the original on March 15 2023 Retrieved March 15 2023 Elledge Stephen J 2015 Accidents and Damage Control Cell 162 6 1196 1200 doi 10 1016 j cell 2015 08 042 PMID 26359977 Elledge S J Davis R W 1987 Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae DNA damage inducible gene required for mitotic viability Molecular and Cellular Biology 7 8 2783 2793 doi 10 1128 mcb 7 8 2783 2793 1987 PMC 367895 PMID 3313004 RNR2 ribonucleotide diphosphate reductase subunit RNR2 Saccharomyces cerevisiae S288C National Center for Biotechnology Information March 10 2023 Archived from the original on March 29 2023 Retrieved March 29 2023 Zhou Zheng Elledge Stephen J 1993 DUN1 encodes a protein kinase that controls the DNA damage response in yeast Cell 75 6 1119 1127 doi 10 1016 0092 8674 93 90321 g PMID 8261511 S2CID 6606697 Retrieved April 3 2023 Sanchez Yolanda Desany Brian A Jones William J Liu Qinghua Wang Bin Elledge Stephen J 1996 Regulation of RAD53 by the ATM like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways Science 271 5247 357 360 Bibcode 1996Sci 271 357S doi 10 1126 science 271 5247 357 PMID 8553072 S2CID 21223989 Retrieved April 3 2023 Sanchez Yolanda Wong Calvin Thoma Richard S Richman Ron Wu Zhiqi Piwnica Worms Helen Elledge Stephen J 1997 Conservation of the Chk1 Checkpoint Pathway in Mammals Linkage of DNA Damage to Cdk Regulation Through Cdc25 Science 277 5331 1497 1501 doi 10 1126 science 277 5331 1497 PMID 9278511 Retrieved April 3 2023 Matsuoka Shuhei Huang Mingxia Elledge Stephen J 1998 Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase Science 282 5395 1893 1897 Bibcode 1998Sci 282 1893M doi 10 1126 science 282 5395 1893 PMID 9836640 Retrieved April 3 2023 Harper J Wade Adami Guy R Wei Nan Keyomarsi Khandan Elledge Stephen J 1993 The p21 Cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin dependent kinases PDF Cell 75 4 805 816 doi 10 1016 0092 8674 93 90499 g PMID 8242751 S2CID 13614794 Archived from the original PDF on April 1 2023 Retrieved April 1 2023 Durfee Tim Becherer Kathleen Chen Phang Lang Yeh Shiou Hwei Yang Yanzhu Kilburn April E Lee Wen Hwa Elledge Stephen J 1993 The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit PDF Genes amp Development 7 9 555 569 doi 10 1101 gad 7 4 555 PMID 8384581 S2CID 23631016 Archived from the original PDF on April 1 2023 Retrieved April 1 2023 Elledge S J Spottswood M R 1991 A new human p34 protein kinase CDK2 identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae is a homolog of Xenopus Eg1 EMBO Journal 10 9 2653 2659 doi 10 1002 j 1460 2075 1991 tb07808 x PMC 452966 PMID 1714386 Bai Chang Sen Partha Hofmann Kay Ma Lei Goebl Mark Harper J Wade Elledge Stephen J 1996 SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif the F Box Cell 86 2 263 274 doi 10 1016 s0092 8674 00 80098 7 PMID 8706131 Kipreos Edward T Pagano Michele 2000 The F box protein family Genome Biology 1 5 reviews3002 1 doi 10 1186 gb 2000 1 5 reviews3002 PMC 138887 PMID 11178263 Xu George J Kula Tomasz Xu Qikai Li Mamie Z Vernon Suzanne D Ndung u Thumbi Ruxrungtham Kiat Sanchez Jorge Brander Christian Chung Raymond T O Connor Kevin C Walker Bruce Larman H Benjamin Elledge Stephen J 2015 Comprehensive serological profiling of human populations using a synthetic human virome Science 348 6299 aaa0698 doi 10 1126 science aaa0698 PMC 4844011 PMID 26045439 Abbas Anzar A Test Tells the Tale HHMI Bulletin Vol 28 no 3 Howard Hughes Medical Institute Archived from the original on April 3 2023 Retrieved April 5 2023 Bridger Haley June 4 2015 Viral History in a Drop of Blood Harvard Medical School Archived from the original on April 5 2023 Retrieved April 5 2023 Davoli Teresa Xu Andrew Wei Mengwasser Kristen E Sack Laura M Yoon John C Park Peter J Elledge Stephen J 2013 Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome Cell 155 4 948 962 doi 10 1016 j cell 2013 10 011 PMC 3891052 PMID 24183448 Null January 30 2017 Interview with 2017 Breakthrough Prize winner Steve Elledge Proceedings of the National Academy of Sciences Archived from the original on April 6 2023 Retrieved April 6 2023 Elledge Stephen J October 27 2020 2 5 Million Person Years of Life Have Been Lost Due to COVID 19 in the United States medRxiv 10 1101 2020 10 18 20214783 Weintraub Karen October 20 2020 The shocking impact of COVID 19 Americans young and old have lost 2 5 million years of life Harvard researcher says USA Today Archived from the original on March 25 2023 Retrieved March 23 2023 Deese Kaelan October 21 2020 Harvard researcher estimates COVID 19 has cost US 2 5 million years of life The Hill Archived from the original on March 25 2023 Retrieved March 23 2023 Wu Katherine J October 21 2020 The Coronavirus Has Claimed 2 5 Million Years of Potential Life in the U S Study Finds The New York Times Archived from the original on December 31 2022 Retrieved December 31 2022 a b Stephen Elledge Gruber Foundation Archived from the original on March 17 2023 Retrieved March 17 2023 Mitzi I Kuroda Ph D Department of Genetics Harvard Medical School November 2021 Archived from the original on March 17 2023 Retrieved March 17 2023 Movers Nature 423 6938 464 2003 Bibcode 2003Natur 423 464 doi 10 1038 nj6938 464a 2001 Prize Winners Memorial Sloan Kettering Cancer Center Archived from the original on March 19 2023 Retrieved March 19 2023 NAS Award in Molecular Biology National Academy of Sciences Archived from the original on March 18 2023 Retrieved March 18 2023 Stephen J Elledge National Academy of Sciences Archived from the original on March 18 2023 Retrieved March 18 2023 Stephen Elledge American Academy of Arts and Sciences Archived from the original on March 19 2023 Retrieved March 19 2023 Hans Sigrist Prize Winners Hans Sigrist Foundation October 15 2021 Archived from the original on March 14 2023 Retrieved March 14 2023 Haber James E 2005 The 2005 Genetics Society of America Medal Genetics 169 2 506 507 doi 10 1093 genetics 169 2 506 PMC 1449134 PMID 15731513 Archived from the original on March 18 2023 Retrieved March 18 2023 a b Stephen J Elledge PhD American Association for Cancer Research Archived from the original on March 19 2023 Retrieved March 19 2023 Stephen J Elledge Ph D National Academy of Medicine Archived from the original on March 20 2023 Retrieved March 20 2023 2010 Dickson Prize Winner Dickson Prize in Medicine Archived from the original on March 19 2023 Retrieved March 19 2023 Past Winners Brandeis University Archived from the original on March 19 2023 Retrieved March 19 2023 2015 Albert Lasker Basic Medical Research Award Lasker Award Archived from the original on March 19 2023 Retrieved March 19 2023 Stephen J Elledge Breakthrough Prize Archived from the original on March 17 2023 Retrieved March 17 2023 2017 Alumni Award recipient Stephen Elledge 78 LAS University of Illinois Alumni Association June 22 2017 Archived from the original on March 23 2023 Retrieved March 23 2023 Elected Fellows American Association for the Advancement of Science Archived from the original on March 20 2023 Retrieved March 20 2023 External links editHis academic home page His Howard Hughes Medical Institute bio Elledge Lab Page Retrieved from https en wikipedia org w index php title Stephen Elledge amp oldid 1209339999, wikipedia, wiki, book, books, library,

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