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Stephen Hsu

October 16, 2023

Stephen Dao Hui Hsu (born 1966) is an American physicist, who has previously worked as a tech executive and a university administrator.

Stephen Hsu
Born
Stephen Dao Hui Hsu

1966 (age 56–57)
Ames, Iowa, U.S.
Alma materCalifornia Institute of Technology
University of California, Berkeley
Scientific career
FieldsPhysics
InstitutionsHarvard University
Yale University
University of Oregon
Michigan State University
ThesisTopics in particle physics and cosmology (1991)
Stephen Hsu
Simplified Chinese徐道辉
Traditional Chinese徐道輝
Hanyu PinyinXú Dào Huī

Early life and education Edit

Hsu was born and raised in Ames, Iowa.[1] His father Cheng Ting Hsu (1923–1996), who was born in Wenling, Zhejiang, in what was then the Republic of China, was a professor of aerospace engineering at Iowa State University in Ames from 1958 to 1989.[2] Stephen Hsu's mother was also originally from China, and Hsu had a grandfather who served as a general in the National Revolutionary Army of the Chinese Kuomintang government.[1] At age 12, Hsu took his first college course, in computer science, and he took physics and mathematics courses at Iowa State while attending Ames High School.[3][4][5]

Hsu received a B.S. from the California Institute of Technology (Caltech) in 1986 at age 19, and a Ph.D. from the University of California, Berkeley in 1991. After his doctorate, he was a Harvard Junior Fellow and Superconducting Super Collider Fellow from 1991 to 1994.

 
Richard Feynman and Stephen Hsu (age 19). 1986 Caltech graduation.

Career Edit

In 1995, he became an assistant professor at Yale University before moving to the University of Oregon in 1998, where he became a full professor of theoretical physics and director of the Institute of Theoretical Science. Hsu's research has focused on a number of areas in particle physics and cosmology, including phase transitions in the early universe, the ground state of quark matter at high density,[6] black holes[7] and quantum information,[8] minimum length from quantum gravity,[9] dark energy,[10] and quantum foundations.[11]

In July 2012, Michigan State University named him vice president for research and graduate studies. At the time, Inside Higher Ed and Lansing State Journal described the appointment as controversial, due to Hsu's comments endorsing research into using genetic modification to increase human intelligence, and his blog posts describing human race categorization as biologically valid.[12][13]

On June 10, 2020, the MSU graduate student union began calling for Hsu to be removed from the administrative position. The MSU student association also called for his removal, and multiple petitions were circulated, including a counter-petition.[14][15] As of June 17, petitions for removal had 700 and 470 signatures, while the counter petition had over 970 signatures.[16] On June 19, 2020 MSU president Samuel L. Stanley announced that Hsu had resigned as vice president, returning to a tenured faculty position.[16][14] Hsu made it clear that it was Stanley who requested his resignation, and that he did not agree with Stanley's decision.[17]

Technology work Edit

In 2000, Hsu went on leave from the University of Oregon to create Safeweb, an anonymizer service.[18][1] In 2003, Symantec acquired SafeWeb for its SSL VPN technology (rack-mounted security hardware appliance).[19]

Hsu is a founder of Genomic Prediction, a company that develops technology for advanced genetic testing.[20][21]

Hsu also has an interest in psychometrics[22] and human genetic variation, which he writes about in his blog and in other publications.[23][24][25][26]

In 2017, Hsu and five collaborators published a paper in Genetics on the use of lasso to construct genomic predictors of complex human traits (height, bone density, cognitive ability), using data from the UK Biobank. Their genotype height predictor estimated adult height within an accuracy of roughly one inch.[27]

In 2018 his research group used the method on the same dataset to build genomic predictors for complex diseases such as hypothyroidism, (resistive) hypertension, type 1 and 2 diabetes, breast cancer, prostate cancer, testicular cancer, gallstones, glaucoma, gout, atrial fibrillation, high cholesterol, asthma, basal cell carcinoma, malignant melanoma, and heart attack. Outliers in risk score (e.g., 99th percentile) were shown, in out-of-sample validation tests, to have up to ten times the risk of ordinary individuals for the specific conditions.[28][29] The predictors use as input information dozens to thousands of common SNPs measured for each individual.[21]

He serves as scientific adviser to BGI (formerly Beijing Genomics Institute), and as a member of its Cognitive Genomics Lab.[30]

References Edit

  1. ^ a b c Kopytoff, Verne (September 4, 2001). "CEO says Safeweb plan will help open China". San Francisco Chronicle. from the original on July 20, 2003. Retrieved June 28, 2020.
  2. ^ Hsu, Steve (April 1, 2008). "Hsu scholarship at Caltech". Information Processing. Retrieved June 28, 2020.
  3. ^ Hsu, Steve (November 9, 2010). "School daze". Information Processing. Blogspot. Retrieved June 28, 2020.
  4. ^ Hsu, Stephen (December 7, 2014). "Feynman Lectures: Epilogue". Michigan State University. Retrieved June 28, 2020.
  5. ^ Hsu, Steve (August 26, 2012). "Back in the MACT". Information Processing. Blogspot. Retrieved June 28, 2020.
  6. ^ Evans, Nick; Hormuzdiar, James; Hsu, Stephen D.H.; Schwetz, Myck (2000). "On the QCD ground state at high density". Nuclear Physics B. 581 (1–2): 391–408. arXiv:hep-ph/9910313. Bibcode:2000NuPhB.581..391E. doi:10.1016/S0550-3213(00)00253-4. S2CID 14766144.
  7. ^ Hsu, Stephen D.H. (2003). "Quantum production of black holes". Physics Letters B. 555 (1–2): 92–98. arXiv:hep-ph/0203154. Bibcode:2003PhLB..555...92H. doi:10.1016/S0370-2693(03)00012-1. S2CID 5793284.
  8. ^ Hsu, Stephen D. H.; Reeb, David (2009). "Black holes, information, and decoherence". Physical Review D. 79 (12): 124037. arXiv:0903.2258. Bibcode:2009PhRvD..79l4037H. doi:10.1103/PhysRevD.79.124037. S2CID 119189621.
  9. ^ Calmet, Xavier; Graesser, Michael; Hsu, Stephen D. H. (2004). "Minimum Length from Quantum Mechanics and Classical General Relativity". Physical Review Letters. 93 (21): 211101. arXiv:hep-th/0405033. Bibcode:2004PhRvL..93u1101C. doi:10.1103/PhysRevLett.93.211101. PMID 15600988. S2CID 6699522.
  10. ^ Hsu, Stephen D.H. (2004). "Entropy bounds and dark energy". Physics Letters B. 594 (1–2): 13–16. arXiv:hep-th/0403052. Bibcode:2004PhLB..594...13H. doi:10.1016/j.physletb.2004.05.020. S2CID 14447957.
  11. ^ Hsu, Stephen D.H (2015). "The measure problem in no-collapse (many worlds) quantum mechanics". arXiv:1511.08881 [quant-ph].
  12. ^ Miller, Matthew (October 7, 2012). "From 2012: New MSU VP for research has start-up experience, but controversial views concern some". Lansing State Journal. Retrieved June 18, 2020. The concerns HoSang laid out in his letter went beyond the BGI project. They were equally about positions Hsu had taken in his blog years earlier: that race is "clearly" a valid biological concept, that whether there are more-than-superficial differences between groups (in areas such as cognitive ability, personality and athletic prowess) is an open question.
  13. ^ Flaherty, Colleen (May 29, 2013). "Quest for 'Genius Babies'?". Inside Higher Ed. Retrieved June 28, 2020.
  14. ^ a b Guzman, Wendy (19 June 2020). "Michigan State VP of Research Stephen Hsu resigns". The State News. Retrieved 20 June 2020.
  15. ^ Lyons, Craig (15 June 2020). "Petition seeks removal of MSU VP of research over controversial comments, research". Lansing State Journal. USA Today. Retrieved 20 June 2020.
  16. ^ a b "MSU VP of Research resigns after calls to be removed". WLNS.com. No. 20 June 2020. Nexstar. Retrieved 21 June 2020.
  17. ^ "Resignation". infoproc.blogspot.com. Retrieved 19 June 2020.
  18. ^ "Punching Holes In Internet Walls". The New York Times. 2001-04-26. Retrieved 2020-05-19.
  19. ^ "Symantec purchases SSL VPN maker SafeWeb". Retrieved 2020-06-21.
  20. ^ "Modern genetics will improve health and usher in "designer" children". The Economist. 2019-11-07. Retrieved 2020-04-23.
  21. ^ a b "Polygenic Risk Scores and Genomic Prediction: Q&A with Stephen Hsu". genengnews.com. 2019-04-01. Retrieved 2020-05-13.
  22. ^ Clynes, Tom (2016-10-06). "Where Nobel winners get their start". Nature. 538 (7624): 152. Bibcode:2016Natur.538..152C. doi:10.1038/nature.2016.20757. PMID 27734890. S2CID 4466329.
  23. ^ "Nautilus Magazine: Super-Intelligent Humans". nautil.us. 2014-10-16. Retrieved 2015-12-23.
  24. ^ "Nautilus Magazine: Smart Machines". nautil.us. 2015-09-03. Retrieved 2015-12-23.
  25. ^ Hsu, Stephen D. H. (2014). "Genetic Architecture of Intelligence". arXiv:1408.3421 [q-bio.GN].
  26. ^ "Intelligence.org: Hsu on Cognitive Genomics". intelligence.org. 2013-08-31. Retrieved 2015-12-23.
  27. ^ Lello, Louis; Avery, Steven G.; Tellier, Laurent; Vazquez, Ana; Campos, Gustavo de los; Hsu, Stephen D. H. (2017-09-18). "Accurate Genomic Prediction Of Human Height". Genetics. 210 (2): 477–497. arXiv:1709.06489. Bibcode:2017arXiv170906489L. bioRxiv 10.1101/190124. doi:10.1534/genetics.118.301267. PMC 6216598. PMID 30150289.
  28. ^ Hsu, Stephen D. H.; Tellier, Laurent CAM; Yong, Soke Yuen; Raben, Timothy; Lello, Louis (2018-12-27). "Genomic Prediction of Complex Disease Risk". bioRxiv 10.1101/506600.
  29. ^ "AI and the Genetic Revolution". Harvard Business Review. 2019-05-08. ISSN 0017-8012. Retrieved 2019-05-20.
  30. ^ Yong, Ed (May 16, 2013). "Chinese project probes the genetics of genius". Nature News. 497 (7449): 297–299. Bibcode:2013Natur.497..297Y. doi:10.1038/497297a. PMID 23676731.

External links Edit

  • Faculty page
  • Blog
  • Podcast
  • Genomic Prediction

October 16, 2023
stephen, stephen, born, 1966, american, physicist, previously, worked, tech, executive, university, administrator, bornstephen, hsu1966, ames, iowa, alma, matercalifornia, institute, technologyuniversity, california, berkeleyscientific, careerfieldsphysicsinst. Stephen Dao Hui Hsu born 1966 is an American physicist who has previously worked as a tech executive and a university administrator Stephen HsuBornStephen Dao Hui Hsu1966 age 56 57 Ames Iowa U S Alma materCalifornia Institute of TechnologyUniversity of California BerkeleyScientific careerFieldsPhysicsInstitutionsHarvard University Yale University University of Oregon Michigan State UniversityThesisTopics in particle physics and cosmology 1991 Stephen HsuSimplified Chinese徐道辉Traditional Chinese徐道輝Hanyu PinyinXu Dao Hui Contents 1 Early life and education 2 Career 3 Technology work 4 References 5 External linksEarly life and education EditHsu was born and raised in Ames Iowa 1 His father Cheng Ting Hsu 1923 1996 who was born in Wenling Zhejiang in what was then the Republic of China was a professor of aerospace engineering at Iowa State University in Ames from 1958 to 1989 2 Stephen Hsu s mother was also originally from China and Hsu had a grandfather who served as a general in the National Revolutionary Army of the Chinese Kuomintang government 1 At age 12 Hsu took his first college course in computer science and he took physics and mathematics courses at Iowa State while attending Ames High School 3 4 5 Hsu received a B S from the California Institute of Technology Caltech in 1986 at age 19 and a Ph D from the University of California Berkeley in 1991 After his doctorate he was a Harvard Junior Fellow and Superconducting Super Collider Fellow from 1991 to 1994 nbsp Richard Feynman and Stephen Hsu age 19 1986 Caltech graduation Career EditIn 1995 he became an assistant professor at Yale University before moving to the University of Oregon in 1998 where he became a full professor of theoretical physics and director of the Institute of Theoretical Science Hsu s research has focused on a number of areas in particle physics and cosmology including phase transitions in the early universe the ground state of quark matter at high density 6 black holes 7 and quantum information 8 minimum length from quantum gravity 9 dark energy 10 and quantum foundations 11 In July 2012 Michigan State University named him vice president for research and graduate studies At the time Inside Higher Ed and Lansing State Journal described the appointment as controversial due to Hsu s comments endorsing research into using genetic modification to increase human intelligence and his blog posts describing human race categorization as biologically valid 12 13 On June 10 2020 the MSU graduate student union began calling for Hsu to be removed from the administrative position The MSU student association also called for his removal and multiple petitions were circulated including a counter petition 14 15 As of June 17 petitions for removal had 700 and 470 signatures while the counter petition had over 970 signatures 16 On June 19 2020 MSU president Samuel L Stanley announced that Hsu had resigned as vice president returning to a tenured faculty position 16 14 Hsu made it clear that it was Stanley who requested his resignation and that he did not agree with Stanley s decision 17 Technology work EditIn 2000 Hsu went on leave from the University of Oregon to create Safeweb an anonymizer service 18 1 In 2003 Symantec acquired SafeWeb for its SSL VPN technology rack mounted security hardware appliance 19 Hsu is a founder of Genomic Prediction a company that develops technology for advanced genetic testing 20 21 Hsu also has an interest in psychometrics 22 and human genetic variation which he writes about in his blog and in other publications 23 24 25 26 In 2017 Hsu and five collaborators published a paper in Genetics on the use of lasso to construct genomic predictors of complex human traits height bone density cognitive ability using data from the UK Biobank Their genotype height predictor estimated adult height within an accuracy of roughly one inch 27 In 2018 his research group used the method on the same dataset to build genomic predictors for complex diseases such as hypothyroidism resistive hypertension type 1 and 2 diabetes breast cancer prostate cancer testicular cancer gallstones glaucoma gout atrial fibrillation high cholesterol asthma basal cell carcinoma malignant melanoma and heart attack Outliers in risk score e g 99th percentile were shown in out of sample validation tests to have up to ten times the risk of ordinary individuals for the specific conditions 28 29 The predictors use as input information dozens to thousands of common SNPs measured for each individual 21 He serves as scientific adviser to BGI formerly Beijing Genomics Institute and as a member of its Cognitive Genomics Lab 30 References Edit a b c Kopytoff Verne September 4 2001 CEO says Safeweb plan will help open China San Francisco Chronicle Archived from the original on July 20 2003 Retrieved June 28 2020 Hsu Steve April 1 2008 Hsu scholarship at Caltech Information Processing Retrieved June 28 2020 Hsu Steve November 9 2010 School daze Information Processing Blogspot Retrieved June 28 2020 Hsu Stephen December 7 2014 Feynman Lectures Epilogue Michigan State University Retrieved June 28 2020 Hsu Steve August 26 2012 Back in the MACT Information Processing Blogspot Retrieved June 28 2020 Evans Nick Hormuzdiar James Hsu Stephen D H Schwetz Myck 2000 On the QCD ground state at high density Nuclear Physics B 581 1 2 391 408 arXiv hep ph 9910313 Bibcode 2000NuPhB 581 391E doi 10 1016 S0550 3213 00 00253 4 S2CID 14766144 Hsu Stephen D H 2003 Quantum production of black holes Physics Letters B 555 1 2 92 98 arXiv hep ph 0203154 Bibcode 2003PhLB 555 92H doi 10 1016 S0370 2693 03 00012 1 S2CID 5793284 Hsu Stephen D H Reeb David 2009 Black holes information and decoherence Physical Review D 79 12 124037 arXiv 0903 2258 Bibcode 2009PhRvD 79l4037H doi 10 1103 PhysRevD 79 124037 S2CID 119189621 Calmet Xavier Graesser Michael Hsu Stephen D H 2004 Minimum Length from Quantum Mechanics and Classical General Relativity Physical Review Letters 93 21 211101 arXiv hep th 0405033 Bibcode 2004PhRvL 93u1101C doi 10 1103 PhysRevLett 93 211101 PMID 15600988 S2CID 6699522 Hsu Stephen D H 2004 Entropy bounds and dark energy Physics Letters B 594 1 2 13 16 arXiv hep th 0403052 Bibcode 2004PhLB 594 13H doi 10 1016 j physletb 2004 05 020 S2CID 14447957 Hsu Stephen D H 2015 The measure problem in no collapse many worlds quantum mechanics arXiv 1511 08881 quant ph Miller Matthew October 7 2012 From 2012 New MSU VP for research has start up experience but controversial views concern some Lansing State Journal Retrieved June 18 2020 The concerns HoSang laid out in his letter went beyond the BGI project They were equally about positions Hsu had taken in his blog years earlier that race is clearly a valid biological concept that whether there are more than superficial differences between groups in areas such as cognitive ability personality and athletic prowess is an open question Flaherty Colleen May 29 2013 Quest for Genius Babies Inside Higher Ed Retrieved June 28 2020 a b Guzman Wendy 19 June 2020 Michigan State VP of Research Stephen Hsu resigns The State News Retrieved 20 June 2020 Lyons Craig 15 June 2020 Petition seeks removal of MSU VP of research over controversial comments research Lansing State Journal USA Today Retrieved 20 June 2020 a b MSU VP of Research resigns after calls to be removed WLNS com No 20 June 2020 Nexstar Retrieved 21 June 2020 Resignation infoproc blogspot com Retrieved 19 June 2020 Punching Holes In Internet Walls The New York Times 2001 04 26 Retrieved 2020 05 19 Symantec purchases SSL VPN maker SafeWeb Retrieved 2020 06 21 Modern genetics will improve health and usher in designer children The Economist 2019 11 07 Retrieved 2020 04 23 a b Polygenic Risk Scores and Genomic Prediction Q amp A with Stephen Hsu genengnews com 2019 04 01 Retrieved 2020 05 13 Clynes Tom 2016 10 06 Where Nobel winners get their start Nature 538 7624 152 Bibcode 2016Natur 538 152C doi 10 1038 nature 2016 20757 PMID 27734890 S2CID 4466329 Nautilus Magazine Super Intelligent Humans nautil us 2014 10 16 Retrieved 2015 12 23 Nautilus Magazine Smart Machines nautil us 2015 09 03 Retrieved 2015 12 23 Hsu Stephen D H 2014 Genetic Architecture of Intelligence arXiv 1408 3421 q bio GN Intelligence org Hsu on Cognitive Genomics intelligence org 2013 08 31 Retrieved 2015 12 23 Lello Louis Avery Steven G Tellier Laurent Vazquez Ana Campos Gustavo de los Hsu Stephen D H 2017 09 18 Accurate Genomic Prediction Of Human Height Genetics 210 2 477 497 arXiv 1709 06489 Bibcode 2017arXiv170906489L bioRxiv 10 1101 190124 doi 10 1534 genetics 118 301267 PMC 6216598 PMID 30150289 Hsu Stephen D H Tellier Laurent CAM Yong Soke Yuen Raben Timothy Lello Louis 2018 12 27 Genomic Prediction of Complex Disease Risk bioRxiv 10 1101 506600 AI and the Genetic Revolution Harvard Business Review 2019 05 08 ISSN 0017 8012 Retrieved 2019 05 20 Yong Ed May 16 2013 Chinese project probes the genetics of genius Nature News 497 7449 297 299 Bibcode 2013Natur 497 297Y doi 10 1038 497297a PMID 23676731 External links EditFaculty page Blog Podcast Genomic Prediction Retrieved from https en wikipedia org w index php title Stephen Hsu amp oldid 1150257380, wikipedia, wiki, book, books, library,

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