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Sergiu P. Pașca

January 01, 1970

Sergiu P. Pașca (born January 30, 1982) is a Romanian-American scientist and physician at Stanford University in California. He is known for creating and developing stem cell-based models of the human brain and applying organoids and assembloids to gain insights into neuropsychiatric disease.

Sergiu P. Pașca
Pașca in 2018
Born(1982-01-30)January 30, 1982
Cluj-Napoca, Romania
Nationality (legal)American & Romanian
Alma materIuliu Hațieganu University of Medicine and Pharmacy
Scientific career
FieldsNeuroscience, Biology, Stem Cell
InstitutionsStanford University
Academic advisorsRicardo Dolmetsch
Websitewww.pascalab.org

Pașca is the Kenneth T. Norris Endowed Professor of Psychiatry and Behavioral Sciences at Stanford University[1] and the Bonnie Uytengsu and Family Founding Director of Stanford Brain Organogenesis,[2] a neuroscientist and stem cell biologist. He is part of the Stanford Neurosciences Institute, Stanford Bio-X and a fellow of the ChEM-H Institute at Stanford.[1] Pașca was listed among New York Times Visionaries in Medicine and Sciences, he is the recipient of the 2018 Vilcek Award for Creative Biomedical Promise from the Vlicek Foundation,[3] and the 2022 IBRO-Kemali Neuroscience Prize,[4] and he holds a Doctor Honoris Causa.[5] In 2022, he gave a TED talk on reverse engineering the human brain in the laboratory[6] and in 2023 he became a Knight of the Order of Merit.[7]

Early life and education edit

Pașca was born in Cluj-Napoca, in the region of Transylvania. He was raised in nearby Aiud during the last years of communism.[8] Pașca showed early on an interest in chemistry. He set up his first science lab at the age of 11, in the basement of his parents’ house.[9] In the final year of high school, he won a prize in the national chemistry Olympiad, earning a scholarship to attend the university of his choice in Romania. In 2001, Pașca enrolled in the Iuliu Hațieganu University of Medicine and Pharmacy at Cluj-Napoca.[1] As a medical student, he worked with Professor Maria Dronca to explore biochemical defects in autism spectrum disorders. At the same time, he studied electrophysiology at the Max Planck Institute for Brain Research in Frankfurt in Germany under Dr Danko Nikolic. After obtaining his M.D. in 2007, Pașca went to Stanford University in early 2009 as a postdoctoral fellow with Professor Ricardo Dolmetsch. At Stanford, he developed methods to derive neurons from induced pluripotent stem cells (iPSC) and used these neural cultures to identify cellular phenotypes associated with brain disorders, including Timothy syndrome and Dravet syndrome.[10][11][12][13]

In 2014, he was recruited as a tenure-track Assistant Professor at Stanford University and opened his own laboratory.[14] He became a tenured Associate Professor in 2020 and full Professor in 2022. He was soon after named an Endowed Professor at Stanford University.[1]

In 2023, he received a Doctor Honoris Causa (D.H.C.) from Iuliu Hatieganu Medical School in Cluj-Napoca, Romania.

His personal trajectory was described in a Quanta profile[15] by the American journalist Claudia Dreyfus.

Pașca has two children.

Research edit

Pașca’s laboratory at Stanford University explores the biological mechanisms of brain disorders using cellular models of the human brain.[14] Pașca developed some of the early in-a-dish models of disease by deriving neurons from skin cells taken from patients with genetic forms of autism and other neurodevelopmental disorders.[16][17] These patient neurons helped uncover the cellular defects of genetic mutations and demonstrated the promise of this novel technology.

Neural organoids

In his laboratory, Pașca introduced the use of instructive signals to develop lab-grown self-assembling three-dimensional (3D) structures called regionalized neural spheroids or organoids.[18] This method was listed among the Key Advances in hiPSC Disease Modeling of the Last Decade by the journal Cell Stem Cell,[19] and Organoids were named Methods of the Year in 2017 by Nature Methods.[20] These 3D brain tissue resemble specific regions of the nervous system[21][22] and his laboratory has maintained these cultures for over 800 days in vitro to show maturation of cells, including astrocytes, into postnatal stages. His work on astrocytes was inspired by the late Stanford neurobiologist Ben Barres.

Assembloids

Pașca has demonstrated that brain-region specific organoids can be fused to form brain assembloids and employed this preparation to study the cross-talk between cells in the developing human brain and to mimic human brain circuits in a dish.[23] This work was listed among the Top Research Advances of 2017 by the National Institutes of Health.[24] His lab has subsequently developed cortico-striatal[25] and cortico-spinal-muscle assembloids.[26]

Transplantation of organoids

In 2022, his group demonstrated the successful integration of human cortical organoids into the developing rat cerebral cortex. Human neurons displayed advanced maturation in vivo, responded to whisker stimulation and were capable of influencing the behavior of the rat in a reward task.[27]

This work was extensively covered by the press.[28][29][30][31][32] Pașca discussed the ethical implications of his work with the ethicist Insoo Hyun in a video material[33] filmed at the Boston Science Museum.

Stanford Brain Organogenesis

In 2019, Pașca founded the Stanford Brain Organogenesis Program, which is a university wide effort to leverage technologies developed at Stanford to advance our understanding of human brain development and circuit assembly. The program includes Karl Deisseroth, Zhenan Bao, Bianxiao Cui, Michael Lin, Sarah Heilshorn and Hank Greely . Pașca serves as the Bonnie Uytengsu and Family Director. The program is also broadly sharing organoid and assembloids technologies through a free, hands-on course course that brings student from all over the world.[34]

Teaching and public engagement

At Stanford, Pașca teaches neural development and principles of drug discovery in neuroscience. Pașca is also the co-director of the CSHL Workshop on autism spectrum disorders.[35]

In 2022, he gave a TED talk[36] at the Vancouver event describing the potential of human cellular models to understand disease. 

Honors edit

Pașca is a Chan Zuckerberg Initiative Ben Barres Investigator and a CZ BioHub Investigator. He was a New York Stem Cell Foundation Roberston Stem Cell Investigator. His researched activity gained him several awards:

  • Knight of the Order of Merit, The Chancery of Orders (2023)[7]
  • Sumitomo/Sunovion Prize, International College of Neuropsychopharmacology (2023)[37]
  • Doctor Honoris Causa (D.H.C.), Hatieganu Medical School (2023)[5]
  • IBRO Dargut and Milena Kemali International Prize for Basic and Clinical Neurosciences (2022)[38]
  • Judson Daland Prize for Outstanding Achievement in Clinical Investigation, American Society of Philosophy (2021)[39]
  • Joseph Altman Award in Developmental Neuroscience (2021)[40]
  • Schizophrenia Basic Research Award (2021)[41]
  • C.J. Herrick Award in Neuroanatomy (2020)
  • A.E.Bennett Award, Society of Biological Psychiatry (2018)[42]
  • Daniel H. Efron Award, American College of Neuropsychopharmacology (2018)[43]
  • Günter Blobel Award, American Society of Cell Biology (2018)[44]
  • New York Times Visionaries in Science and Medicine (2018)[45]
  • Vilcek Award for Creative Biomedical Promise (2018)[46]
  • Jordi Folch-Pi Award, American Society for Neurochemistry (2017)[47]
  • NARSAD Independent Investigator Award (2017)[48]
  • NIMH Director's BRAINS Award (2015)
  • MQ Fellow Award for Transforming Mental Health (2014)[49]
  • Sammy Kuo Award (2012)[50]
  • IBRO Outstanding Research Fellow (2009)

In Romania, he was recognized as the Best Romanian student studying abroad in 2012.[51]

References edit

  1. ^ a b c d "Sergiu P. Pașca's Profile | Stanford Profiles". Profiles.stanford.edu. Retrieved 2018-06-07.
  2. ^ "Stanford Brain Organogenesis Program". 8 October 2018.
  3. ^ Lisa M. Krieger (February 1, 2018). "Stanford scientist wins award for immigrant scientists". The Mercury News. Retrieved January 13, 2018.
  4. ^ admin (2021-09-20). "IBRO-Kemali Prize Awarded to Dr. Sergiu P. Pasca". IBRO. Retrieved 2023-10-23.
  5. ^ a b "Sergiu Pașca a primit titlul de Doctor Honoris Causa al UMF Cluj. Fostul student al universității, un lider internațional în neuroștiințe: "E important ca tinerii să se pregătească în străinătate și să se întoarcă în țară"". monitorulcj.ro (in Romanian). 2023-04-29. Retrieved 2023-10-23.
  6. ^ "Sergiu P. Pasca: How we're reverse engineering the human brain in the lab". 24 August 2022.
  7. ^ a b "Stanford University researcher Sergiu Pasca decorated by President Klaus Iohannis". Stiri pe surse. 2023-03-28. Retrieved 2023-10-23.
  8. ^ "The Vilcek Foundation - Sergiu P. Pașca". www.vilcek.org. Retrieved 7 June 2018.
  9. ^ "Rising Star: Sergiu Pașca, scientist at play | Spectrum | Autism Research News". Spectrum | Autism Research News. 19 February 2015. Retrieved 7 June 2018.
  10. ^ Krey, Jocelyn F.; Pașca, Sergiu P.; Shcheglovitov, Aleksandr; et al. (2013). "Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons". Nature Neuroscience. 16 (2): 201–209. doi:10.1038/nn.3307. ISSN 1546-1726. PMC 3568452. PMID 23313911.
  11. ^ Paşca, Sergiu P.; Portmann, Thomas; Voineagu, Irina; et al. (27 November 2011). "Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome". Nature Medicine. 17 (12): 1657–1662. doi:10.1038/nm.2576. ISSN 1546-170X. PMC 3517299. PMID 22120178.
  12. ^ Sun, Yishan; Paşca, Sergiu P; Portmann, Thomas; et al. (26 July 2016). "A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients". eLife. 5. doi:10.7554/eLife.13073. ISSN 2050-084X. PMC 4961470. PMID 27458797.
  13. ^ Tian, Yuan; Voineagu, Irina; Paşca, Sergiu P.; et al. (2014). "Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome". Genome Medicine. 6 (10): 75. doi:10.1186/s13073-014-0075-5. ISSN 1756-994X. PMC 4213483. PMID 25360157.
  14. ^ a b "Pașca Lab @ Stanford University - Home". Pascalab.org. 2018-05-24. Retrieved 2018-06-07.
  15. ^ Dreifus, Claudia (October 12, 2022). "Human Brains Are Hard to Study. He Grows Useful Substitutes". Quanta Magazine.
  16. ^ Paşca, Sergiu P.; Panagiotakos, Georgia; Dolmetsch, Ricardo E. (2014). "Generating human neurons in vitro and using them to understand neuropsychiatric disease". Annual Review of Neuroscience. 37: 479–501. doi:10.1146/annurev-neuro-062012-170328. ISSN 1545-4126. PMID 25002278.
  17. ^ "The Vilcek Foundation - Sergiu P. Pașca". Vilcek.org. Retrieved 2018-06-07.
  18. ^ Pașca, Sergiu P. (2018). "The rise of three-dimensional human brain cultures". Nature. 553 (7689): 437–445. Bibcode:2018Natur.553..437P. doi:10.1038/nature25032. ISSN 1476-4687. PMID 29364288. S2CID 205262820.
  19. ^ Passier, Robert; Orlova, Valeria; Mummery, Christine (March 2016). "Complex Tissue and Disease Modeling using hiPSCs". Cell Stem Cell. 18 (3): 309–321. doi:10.1016/j.stem.2016.02.011. PMID 26942851.
  20. ^ "Method of the Year 2017: Organoids". Nature Methods. 15: 1. 3 January 2018. doi:10.1038/nmeth.4575.
  21. ^ Paşca, Anca M.; Sloan, Steven A.; Clarke, Laura E.; et al. (2015). "Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture". Nature Methods. 12 (7): 671–678. doi:10.1038/nmeth.3415. ISSN 1548-7105. PMC 4489980. PMID 26005811.
  22. ^ Sloan, Steven A.; Darmanis, Spyros; Huber, Nina; et al. (16 August 2017). "Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells". Neuron. 95 (4): 779–790.e6. doi:10.1016/j.neuron.2017.07.035. ISSN 1097-4199. PMC 5890820. PMID 28817799.
  23. ^ Birey, Fikri; Andersen, Jimena; Makinson, Christopher D.; et al. (2017). "Assembly of functionally integrated human forebrain spheroids". Nature. 545 (7652): 54–59. Bibcode:2017Natur.545...54B. doi:10.1038/nature22330. ISSN 1476-4687. PMC 5805137. PMID 28445465.
  24. ^ "2017 Research Highlights — Insights from the Lab". National Institutes of Health (NIH). 15 December 2017. Retrieved 7 June 2018.
  25. ^ Miura, Yuki; Li, Min-Yin; Birey, Fikri; Ikeda, Kazuya; Revah, Omer; Thete, Mayuri Vijay; Park, Jin-Young; Puno, Alyssa; Lee, Samuel H.; Porteus, Matthew H.; Pașca, Sergiu P. (December 2020). "Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells". Nature Biotechnology. 38 (12): 1421–1430. doi:10.1038/s41587-020-00763-w. ISSN 1546-1696. PMC 9042317.
  26. ^ Andersen, Jimena; Revah, Omer; Miura, Yuki; Thom, Nicholas; Amin, Neal D.; Kelley, Kevin W.; Singh, Mandeep; Chen, Xiaoyu; Thete, Mayuri Vijay; Walczak, Elisabeth M.; Vogel, Hannes; Fan, H. Christina; Paşca, Sergiu P. (2020-12-23). "Generation of Functional Human 3D Cortico-Motor Assembloids". Cell. 183 (7): 1913–1929.e26. doi:10.1016/j.cell.2020.11.017. ISSN 0092-8674. PMC 8711252.
  27. ^ Revah, Omer; Gore, Felicity; Kelley, Kevin W.; Andersen, Jimena; Sakai, Noriaki; Chen, Xiaoyu; Li, Min-Yin; Birey, Fikri; Yang, Xiao; Saw, Nay L.; Baker, Samuel W.; Amin, Neal D.; Kulkarni, Shravanti; Mudipalli, Rachana; Cui, Bianxiao (2022-10-13). "Maturation and circuit integration of transplanted human cortical organoids". Nature. 610 (7931): 319–326. Bibcode:2022Natur.610..319R. doi:10.1038/s41586-022-05277-w. ISSN 0028-0836. PMC 9556304. PMID 36224417.
  28. ^ Zimmer, Carl (2022-10-12). "Human Brain Cells Grow in Rats, and Feel What the Rats Feel". The New York Times. ISSN 0362-4331. Retrieved 2023-11-01.
  29. ^ Cookson, Clive (2022-10-12). "Human-to-rat brain tissue implant boosts psychiatric disease research". Financial Times. Retrieved 2023-11-01.
  30. ^ Sample, Ian; editor, Ian Sample Science (2022-10-12). "Human neurons transplanted into rats to help study brain disorders". The Guardian. ISSN 0261-3077. Retrieved 2023-11-01. {{cite news}}: |last2= has generic name (help)
  31. ^ "What happens when human brain tissue is implanted into rats". The Economist. ISSN 0013-0613. Retrieved 2023-11-01.
  32. ^ "Un organoïde cérébral humain implanté dans un cerveau de rat". Le Monde.fr (in French). 2022-10-31. Retrieved 2023-11-01.
  33. ^ Using Human Brain Cells in Rats to Understand Psychiatric Disorders with Dr. Sergiu Pasca, retrieved 2023-11-01
  34. ^ "Stanford Brain Organogenesis Workshop". Stanford Brain Organogenesis. Retrieved 2023-11-17.
  35. ^ "Workshop on Autism Spectrum Disorders | CSHL". meetings.cshl.edu. Retrieved 2022-04-14.
  36. ^ Pasca, Sergiu P. (2022-08-24), Sergiu P. Pasca: How we're reverse engineering the human brain in the lab, retrieved 2023-11-17
  37. ^ "Brain Health Research Awards". cinp.org. Retrieved 2023-11-17.
  38. ^ "IBRO-Kemali Prize Awarded to Dr. Sergiu P. Pasca". IBRO. 2021-09-20. Retrieved 2022-05-15.
  39. ^ "2021 Judson Daland Prize". American Philosophical Society. Retrieved 2022-05-15.
  40. ^ "Announcement of the Awardee of the 2021 Joseph Altman Award in Developmental Neuroscience". The Japan Neuroscience Society. Retrieved 2022-05-15.
  41. ^ "2021 Basic Research Award | Schizophrenia International Research Society". Retrieved 2022-05-15.
  42. ^ "A.E. Bennett Basic Research Award | Society of Biological Psychiatry". Retrieved 2022-05-15.
  43. ^ "Daniel H. Efron Research Previous Award Winners". ACNP. Retrieved 2022-05-15.
  44. ^ "Neuroscientist and Stem Cell Biologist Sergiu Pasca to Receive ASCB Early Career Life Scientist Award". ASCB. 2018-10-17. Retrieved 2022-05-15.
  45. ^ Weintraub, Karen (2018-05-24). "Using Medicine and Science to Improve the Quality of Life". The New York Times. ISSN 0362-4331. Retrieved 2022-05-15.
  46. ^ "Sergiu P. Pasca". Vilcek Foundation. Retrieved 2022-05-15.
  47. ^ "American Society for Neurochemistry - Recipients of the Jordi Folch-Pi Award". www.asneurochem.org. Retrieved 2022-05-15.
  48. ^ "Sergiu P. Pasca, M.D." Brain & Behavior Research Foundation. 2017-07-18. Retrieved 2022-05-15.
  49. ^ "Identifying cellular mechanisms of disease and novel therapeutic targets in neurons derived from patients with schizophrenia | MQ Mental Health Research". www.mqmentalhealth.org. 2020-10-28. Retrieved 2022-05-15.
  50. ^ University, © Stanford; Stanford; California 94305 (2017-07-03). "Sammy Kuo Award Winners". Wu Tsai Neurosciences Institute. Retrieved 2022-05-15.{{cite web}}: CS1 maint: numeric names: authors list (link)
  51. ^ Craciun, Oana (14 January 2013). "EXCLUSIV Sergiu Pașca, studentul român al anului 2012 din străinătate: "Ar fi trebuit să plec la studii mai devreme"". Adevărul (in Romanian). Retrieved 13 March 2016.

January 01, 1970
sergiu, pașca, born, january, 1982, romanian, american, scientist, physician, stanford, university, california, known, creating, developing, stem, cell, based, models, human, brain, applying, organoids, assembloids, gain, insights, into, neuropsychiatric, dise. Sergiu P Pașca born January 30 1982 is a Romanian American scientist and physician at Stanford University in California He is known for creating and developing stem cell based models of the human brain and applying organoids and assembloids to gain insights into neuropsychiatric disease Sergiu P PașcaPașca in 2018Born 1982 01 30 January 30 1982Cluj Napoca RomaniaNationality legal American amp RomanianAlma materIuliu Hațieganu University of Medicine and PharmacyScientific careerFieldsNeuroscience Biology Stem CellInstitutionsStanford UniversityAcademic advisorsRicardo DolmetschWebsitewww wbr pascalab wbr org Pașca is the Kenneth T Norris Endowed Professor of Psychiatry and Behavioral Sciences at Stanford University 1 and the Bonnie Uytengsu and Family Founding Director of Stanford Brain Organogenesis 2 a neuroscientist and stem cell biologist He is part of the Stanford Neurosciences Institute Stanford Bio X and a fellow of the ChEM H Institute at Stanford 1 Pașca was listed among New York Times Visionaries in Medicine and Sciences he is the recipient of the 2018 Vilcek Award for Creative Biomedical Promise from the Vlicek Foundation 3 and the 2022 IBRO Kemali Neuroscience Prize 4 and he holds a Doctor Honoris Causa 5 In 2022 he gave a TED talk on reverse engineering the human brain in the laboratory 6 and in 2023 he became a Knight of the Order of Merit 7 Contents 1 Early life and education 2 Research 3 Honors 4 ReferencesEarly life and education editPașca was born in Cluj Napoca in the region of Transylvania He was raised in nearby Aiud during the last years of communism 8 Pașca showed early on an interest in chemistry He set up his first science lab at the age of 11 in the basement of his parents house 9 In the final year of high school he won a prize in the national chemistry Olympiad earning a scholarship to attend the university of his choice in Romania In 2001 Pașca enrolled in the Iuliu Hațieganu University of Medicine and Pharmacy at Cluj Napoca 1 As a medical student he worked with Professor Maria Dronca to explore biochemical defects in autism spectrum disorders At the same time he studied electrophysiology at the Max Planck Institute for Brain Research in Frankfurt in Germany under Dr Danko Nikolic After obtaining his M D in 2007 Pașca went to Stanford University in early 2009 as a postdoctoral fellow with Professor Ricardo Dolmetsch At Stanford he developed methods to derive neurons from induced pluripotent stem cells iPSC and used these neural cultures to identify cellular phenotypes associated with brain disorders including Timothy syndrome and Dravet syndrome 10 11 12 13 In 2014 he was recruited as a tenure track Assistant Professor at Stanford University and opened his own laboratory 14 He became a tenured Associate Professor in 2020 and full Professor in 2022 He was soon after named an Endowed Professor at Stanford University 1 In 2023 he received a Doctor Honoris Causa D H C from Iuliu Hatieganu Medical School in Cluj Napoca Romania His personal trajectory was described in a Quanta profile 15 by the American journalist Claudia Dreyfus Pașca has two children Research editPașca s laboratory at Stanford University explores the biological mechanisms of brain disorders using cellular models of the human brain 14 Pașca developed some of the early in a dish models of disease by deriving neurons from skin cells taken from patients with genetic forms of autism and other neurodevelopmental disorders 16 17 These patient neurons helped uncover the cellular defects of genetic mutations and demonstrated the promise of this novel technology Neural organoidsIn his laboratory Pașca introduced the use of instructive signals to develop lab grown self assembling three dimensional 3D structures called regionalized neural spheroids or organoids 18 This method was listed among the Key Advances in hiPSC Disease Modeling of the Last Decade by the journal Cell Stem Cell 19 and Organoids were named Methods of the Year in 2017 by Nature Methods 20 These 3D brain tissue resemble specific regions of the nervous system 21 22 and his laboratory has maintained these cultures for over 800 days in vitro to show maturation of cells including astrocytes into postnatal stages His work on astrocytes was inspired by the late Stanford neurobiologist Ben Barres AssembloidsPașca has demonstrated that brain region specific organoids can be fused to form brain assembloids and employed this preparation to study the cross talk between cells in the developing human brain and to mimic human brain circuits in a dish 23 This work was listed among the Top Research Advances of 2017 by the National Institutes of Health 24 His lab has subsequently developed cortico striatal 25 and cortico spinal muscle assembloids 26 Transplantation of organoidsIn 2022 his group demonstrated the successful integration of human cortical organoids into the developing rat cerebral cortex Human neurons displayed advanced maturation in vivo responded to whisker stimulation and were capable of influencing the behavior of the rat in a reward task 27 This work was extensively covered by the press 28 29 30 31 32 Pașca discussed the ethical implications of his work with the ethicist Insoo Hyun in a video material 33 filmed at the Boston Science Museum Stanford Brain OrganogenesisIn 2019 Pașca founded the Stanford Brain Organogenesis Program which is a university wide effort to leverage technologies developed at Stanford to advance our understanding of human brain development and circuit assembly The program includes Karl Deisseroth Zhenan Bao Bianxiao Cui Michael Lin Sarah Heilshorn and Hank Greely Pașca serves as the Bonnie Uytengsu and Family Director The program is also broadly sharing organoid and assembloids technologies through a free hands on course course that brings student from all over the world 34 Teaching and public engagementAt Stanford Pașca teaches neural development and principles of drug discovery in neuroscience Pașca is also the co director of the CSHL Workshop on autism spectrum disorders 35 In 2022 he gave a TED talk 36 at the Vancouver event describing the potential of human cellular models to understand disease Honors editPașca is a Chan Zuckerberg Initiative Ben Barres Investigator and a CZ BioHub Investigator He was a New York Stem Cell Foundation Roberston Stem Cell Investigator His researched activity gained him several awards Knight of the Order of Merit The Chancery of Orders 2023 7 Sumitomo Sunovion Prize International College of Neuropsychopharmacology 2023 37 Doctor Honoris Causa D H C Hatieganu Medical School 2023 5 IBRO Dargut and Milena Kemali International Prize for Basic and Clinical Neurosciences 2022 38 Judson Daland Prize for Outstanding Achievement in Clinical Investigation American Society of Philosophy 2021 39 Joseph Altman Award in Developmental Neuroscience 2021 40 Schizophrenia Basic Research Award 2021 41 C J Herrick Award in Neuroanatomy 2020 A E Bennett Award Society of Biological Psychiatry 2018 42 Daniel H Efron Award American College of Neuropsychopharmacology 2018 43 Gunter Blobel Award American Society of Cell Biology 2018 44 New York Times Visionaries in Science and Medicine 2018 45 Vilcek Award for Creative Biomedical Promise 2018 46 Jordi Folch Pi Award American Society for Neurochemistry 2017 47 NARSAD Independent Investigator Award 2017 48 NIMH Director s BRAINS Award 2015 MQ Fellow Award for Transforming Mental Health 2014 49 Sammy Kuo Award 2012 50 IBRO Outstanding Research Fellow 2009 In Romania he was recognized as the Best Romanian student studying abroad in 2012 51 References edit a b c d Sergiu P Pașca s Profile Stanford Profiles Profiles stanford edu Retrieved 2018 06 07 Stanford Brain Organogenesis Program 8 October 2018 Lisa M Krieger February 1 2018 Stanford scientist wins award for immigrant scientists The Mercury News Retrieved January 13 2018 admin 2021 09 20 IBRO Kemali Prize Awarded to Dr Sergiu P Pasca IBRO Retrieved 2023 10 23 a b Sergiu Pașca a primit titlul de Doctor Honoris Causa al UMF Cluj Fostul student al universității un lider internațional in neuroștiințe E important ca tinerii să se pregătească in străinătate și să se intoarcă in țară monitorulcj ro in Romanian 2023 04 29 Retrieved 2023 10 23 Sergiu P Pasca How we re reverse engineering the human brain in the lab 24 August 2022 a b Stanford University researcher Sergiu Pasca decorated by President Klaus Iohannis Stiri pe surse 2023 03 28 Retrieved 2023 10 23 The Vilcek Foundation Sergiu P Pașca www vilcek org Retrieved 7 June 2018 Rising Star Sergiu Pașca scientist at play Spectrum Autism Research News Spectrum Autism Research News 19 February 2015 Retrieved 7 June 2018 Krey Jocelyn F Pașca Sergiu P Shcheglovitov Aleksandr et al 2013 Timothy syndrome is associated with activity dependent dendritic retraction in rodent and human neurons Nature Neuroscience 16 2 201 209 doi 10 1038 nn 3307 ISSN 1546 1726 PMC 3568452 PMID 23313911 Pasca Sergiu P Portmann Thomas Voineagu Irina et al 27 November 2011 Using iPSC derived neurons to uncover cellular phenotypes associated with Timothy syndrome Nature Medicine 17 12 1657 1662 doi 10 1038 nm 2576 ISSN 1546 170X PMC 3517299 PMID 22120178 Sun Yishan Pasca Sergiu P Portmann Thomas et al 26 July 2016 A deleterious Nav1 1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients eLife 5 doi 10 7554 eLife 13073 ISSN 2050 084X PMC 4961470 PMID 27458797 Tian Yuan Voineagu Irina Pasca Sergiu P et al 2014 Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome Genome Medicine 6 10 75 doi 10 1186 s13073 014 0075 5 ISSN 1756 994X PMC 4213483 PMID 25360157 a b Pașca Lab Stanford University Home Pascalab org 2018 05 24 Retrieved 2018 06 07 Dreifus Claudia October 12 2022 Human Brains Are Hard to Study He Grows Useful Substitutes Quanta Magazine Pasca Sergiu P Panagiotakos Georgia Dolmetsch Ricardo E 2014 Generating human neurons in vitro and using them to understand neuropsychiatric disease Annual Review of Neuroscience 37 479 501 doi 10 1146 annurev neuro 062012 170328 ISSN 1545 4126 PMID 25002278 The Vilcek Foundation Sergiu P Pașca Vilcek org Retrieved 2018 06 07 Pașca Sergiu P 2018 The rise of three dimensional human brain cultures Nature 553 7689 437 445 Bibcode 2018Natur 553 437P doi 10 1038 nature25032 ISSN 1476 4687 PMID 29364288 S2CID 205262820 Passier Robert Orlova Valeria Mummery Christine March 2016 Complex Tissue and Disease Modeling using hiPSCs Cell Stem Cell 18 3 309 321 doi 10 1016 j stem 2016 02 011 PMID 26942851 Method of the Year 2017 Organoids Nature Methods 15 1 3 January 2018 doi 10 1038 nmeth 4575 Pasca Anca M Sloan Steven A Clarke Laura E et al 2015 Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture Nature Methods 12 7 671 678 doi 10 1038 nmeth 3415 ISSN 1548 7105 PMC 4489980 PMID 26005811 Sloan Steven A Darmanis Spyros Huber Nina et al 16 August 2017 Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells Neuron 95 4 779 790 e6 doi 10 1016 j neuron 2017 07 035 ISSN 1097 4199 PMC 5890820 PMID 28817799 Birey Fikri Andersen Jimena Makinson Christopher D et al 2017 Assembly of functionally integrated human forebrain spheroids Nature 545 7652 54 59 Bibcode 2017Natur 545 54B doi 10 1038 nature22330 ISSN 1476 4687 PMC 5805137 PMID 28445465 2017 Research Highlights Insights from the Lab National Institutes of Health NIH 15 December 2017 Retrieved 7 June 2018 Miura Yuki Li Min Yin Birey Fikri Ikeda Kazuya Revah Omer Thete Mayuri Vijay Park Jin Young Puno Alyssa Lee Samuel H Porteus Matthew H Pașca Sergiu P December 2020 Generation of human striatal organoids and cortico striatal assembloids from human pluripotent stem cells Nature Biotechnology 38 12 1421 1430 doi 10 1038 s41587 020 00763 w ISSN 1546 1696 PMC 9042317 Andersen Jimena Revah Omer Miura Yuki Thom Nicholas Amin Neal D Kelley Kevin W Singh Mandeep Chen Xiaoyu Thete Mayuri Vijay Walczak Elisabeth M Vogel Hannes Fan H Christina Pasca Sergiu P 2020 12 23 Generation of Functional Human 3D Cortico Motor Assembloids Cell 183 7 1913 1929 e26 doi 10 1016 j cell 2020 11 017 ISSN 0092 8674 PMC 8711252 Revah Omer Gore Felicity Kelley Kevin W Andersen Jimena Sakai Noriaki Chen Xiaoyu Li Min Yin Birey Fikri Yang Xiao Saw Nay L Baker Samuel W Amin Neal D Kulkarni Shravanti Mudipalli Rachana Cui Bianxiao 2022 10 13 Maturation and circuit integration of transplanted human cortical organoids Nature 610 7931 319 326 Bibcode 2022Natur 610 319R doi 10 1038 s41586 022 05277 w ISSN 0028 0836 PMC 9556304 PMID 36224417 Zimmer Carl 2022 10 12 Human Brain Cells Grow in Rats and Feel What the Rats Feel The New York Times ISSN 0362 4331 Retrieved 2023 11 01 Cookson Clive 2022 10 12 Human to rat brain tissue implant boosts psychiatric disease research Financial Times Retrieved 2023 11 01 Sample Ian editor Ian Sample Science 2022 10 12 Human neurons transplanted into rats to help study brain disorders The Guardian ISSN 0261 3077 Retrieved 2023 11 01 a href Template Cite news html title Template Cite news cite news a last2 has generic name help What happens when human brain tissue is implanted into rats The Economist ISSN 0013 0613 Retrieved 2023 11 01 Un organoide cerebral humain implante dans un cerveau de rat Le Monde fr in French 2022 10 31 Retrieved 2023 11 01 Using Human Brain Cells in Rats to Understand Psychiatric Disorders with Dr Sergiu Pasca retrieved 2023 11 01 Stanford Brain Organogenesis Workshop Stanford Brain Organogenesis Retrieved 2023 11 17 Workshop on Autism Spectrum Disorders CSHL meetings cshl edu Retrieved 2022 04 14 Pasca Sergiu P 2022 08 24 Sergiu P Pasca How we re reverse engineering the human brain in the lab retrieved 2023 11 17 Brain Health Research Awards cinp org Retrieved 2023 11 17 IBRO Kemali Prize Awarded to Dr Sergiu P Pasca IBRO 2021 09 20 Retrieved 2022 05 15 2021 Judson Daland Prize American Philosophical Society Retrieved 2022 05 15 Announcement of the Awardee of the 2021 Joseph Altman Award in Developmental Neuroscience The Japan Neuroscience Society Retrieved 2022 05 15 2021 Basic Research Award Schizophrenia International Research Society Retrieved 2022 05 15 A E Bennett Basic Research Award Society of Biological Psychiatry Retrieved 2022 05 15 Daniel H Efron Research Previous Award Winners ACNP Retrieved 2022 05 15 Neuroscientist and Stem Cell Biologist Sergiu Pasca to Receive ASCB Early Career Life Scientist Award ASCB 2018 10 17 Retrieved 2022 05 15 Weintraub Karen 2018 05 24 Using Medicine and Science to Improve the Quality of Life The New York Times ISSN 0362 4331 Retrieved 2022 05 15 Sergiu P Pasca Vilcek Foundation Retrieved 2022 05 15 American Society for Neurochemistry Recipients of the Jordi Folch Pi Award www asneurochem org Retrieved 2022 05 15 Sergiu P Pasca M D Brain amp Behavior Research Foundation 2017 07 18 Retrieved 2022 05 15 Identifying cellular mechanisms of disease and novel therapeutic targets in neurons derived from patients with schizophrenia MQ Mental Health Research www mqmentalhealth org 2020 10 28 Retrieved 2022 05 15 University c Stanford Stanford California 94305 2017 07 03 Sammy Kuo Award Winners Wu Tsai Neurosciences Institute Retrieved 2022 05 15 a href Template Cite web html title Template Cite web cite web a CS1 maint numeric names authors list link Craciun Oana 14 January 2013 EXCLUSIV Sergiu Pașca studentul roman al anului 2012 din străinătate Ar fi trebuit să plec la studii mai devreme Adevărul in Romanian Retrieved 13 March 2016 Retrieved from https en wikipedia org w index php title Sergiu P Pașca amp oldid 1223380800, wikipedia, wiki, book, books, library,

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