It is distinct from those first discovered in the United Kingdom, South Africa, and Brazil, and is thought to pose a similar threat. The variant is more resistant to neutralizing antibodies, including those gained through vaccination, like how the South African and Brazilian variants appear to be.[3]
Under the simplified naming scheme proposed by the World Health Organization, P.3 has been labeled Theta variant, and was considered a variant of interest (VOI), but not a variant of concern.[4]
As of July 2021, Theta is no longer considered as a variant of interest by the WHO.[4]
Amino acid mutations of SARS-CoV-2 Theta variant plotted on a genome map of SARS-CoV-2 with a focus on the spike.[7]
A total of 14 amino acid replacements were observed in all samples (labeled in red below), including seven spike protein mutations. Among the spike protein mutations, four have been previously associated with lineages of concern (i.e., E484K, N501Y, D614G, and P681H) while three additional replacements were observed towards the C-terminal region of the protein (i.e., E1092K, H1101Y, and V1176F). A single amino acid replacement at the N-terminus of ORF8 (i.e., K2Q) was also found in all samples. Three other mutations were seen in 32 of the 33 samples (labeled in green) including a three-amino acid deletion at the spike protein positions 141 to 143. Lastly, five synonymous mutations (labeled in gray) were also detected in all of the cases.[8]
On February 18, 2021, the Department of Health of the Philippines confirmed the detection of two mutations of COVID-19 in Central Visayas after samples from patients were sent to undergo genome sequencing. The mutations were later named as E484K and N501Y, which were detected in 37 out of 50 samples, with both mutations co-occurrent in 29 out of these. There were no official names for the variants and the full sequence was yet to be identified.[1]
On March 12, 2021, Japan detected the variant on a traveler from the Philippines.[2]
On March 13, 2021, the Department of Health confirmed the mutations constituted a new variant, which was designated as lineage P.3. On the same day, it also confirmed its first case of lineage P.1 in the country. Although the lineages P.1 and P.3 stem from the same lineage B.1.1.28, the department said that the impact of lineage P.3 on vaccine efficacy and transmissibility is yet to be ascertained.[10]
^ abNews, CNN Philippines (February 18, 2021). "DOH confirms new COVID-19 mutations in Central Visayas". Retrieved May 2, 2021. {{cite news}}: |last= has generic name (help)
^ abNews, Kyodo (March 12, 2021). "New coronavirus variant found in traveler from Philippines: Japan". Retrieved May 2, 2021. {{cite news}}: |last= has generic name (help)
^News, Japan Times (March 12, 2021). "Japanese authorities discover a new coronavirus variant in traveler from Philippines". Retrieved May 2, 2021. {{cite news}}: |last= has generic name (help)
^ ab"Tracking SARS-CoV-2 variants". who.int. World Health Organization.{{cite web}}: CS1 maint: url-status (link)
^"Tracking SARS-CoV-2 variants". June 1, 2021. Retrieved June 1, 2021.
^"Spike Variants: Theta variant, aka B.1.128". covdb.stanford.edu. Stanford University Coronavirus Antiviral & Resistance Database. 1 July 2021. Retrieved 2021-07-05.
^Center, Philippine Genome. "PGC SARS-CoV-2 Bulletin No. 7: Detection and characterization of a new SARS-CoV-2 lineage P.3, with spike protein mutations E484K, N501Y, P681H and LGV 141–143 deletion, from samples sequenced through the intensified UP-PGC, UP-NIH and DOH biosurveillance program". Philippine Genome Center.
^News, ABS-CBN (March 13, 2021). "DOH confirms new COVID-19 variant first detected in PH, first case of Brazil variant". Retrieved May 2, 2021. {{cite news}}: |last= has generic name (help)
^News, Rappler (March 17, 2021). "England reports 2 cases of new COVID-19 variant found in Philippines". Retrieved May 2, 2021. {{cite news}}: |last= has generic name (help)
^"Covid-19: Sarawak detects variant reported in the Philippines". April 30, 2021. Retrieved April 30, 2021.
^Pei Pei, Goh (July 8, 2021). "Delta variant detected in Sarawak". Retrieved July 13, 2021. He said for the Theta variant, six cases had been detected in Kuching and seven in Kota Samarahan
^"Variants: distribution of case data, 13 August 2021". August 13, 2021. Retrieved August 13, 2021.
^"Variants in the Netherlands". rivm.nl. Retrieved July 16, 2021.{{cite web}}: CS1 maint: url-status (link)
External links
PANGO lineages: New Variant Report - Report on global distribution of lineage B.1.1.7
GISAID sequencing data base – Tracking of COVID-19 variants
January 20, 2023
sars, theta, variant, theta, variant, also, known, lineage, variants, sars, virus, that, causes, covid, variant, first, identified, philippines, february, 2021, when, mutations, concern, were, detected, central, visayas, detected, japan, march, 2021, when, tra. Theta variant also known as lineage P 3 a is one of the variants of SARS CoV 2 the virus that causes COVID 19 The variant was first identified in the Philippines on February 18 2021 when two mutations of concern were detected in Central Visayas 1 It was detected in Japan on March 12 2021 when a traveler from the Philippines arrived at Narita International Airport in Tokyo 2 It is distinct from those first discovered in the United Kingdom South Africa and Brazil and is thought to pose a similar threat The variant is more resistant to neutralizing antibodies including those gained through vaccination like how the South African and Brazilian variants appear to be 3 Under the simplified naming scheme proposed by the World Health Organization P 3 has been labeled Theta variant and was considered a variant of interest VOI but not a variant of concern 4 As of July 2021 Theta is no longer considered as a variant of interest by the WHO 4 Contents 1 Classification 1 1 Naming 1 2 Mutations 2 History 3 Statistics 4 See also 5 Notes 6 References 7 External linksClassificationNaming On March 17 2021 Public Health England PHE named Lineage P 3 VUI 21MAR 02 5 On June 1 2021 the World Health Organization WHO named lineage P 3 as Theta variant 6 Mutations Amino acid mutations of SARS CoV 2 Theta variant plotted on a genome map of SARS CoV 2 with a focus on the spike 7 A total of 14 amino acid replacements were observed in all samples labeled in red below including seven spike protein mutations Among the spike protein mutations four have been previously associated with lineages of concern i e E484K N501Y D614G and P681H while three additional replacements were observed towards the C terminal region of the protein i e E1092K H1101Y and V1176F A single amino acid replacement at the N terminus of ORF8 i e K2Q was also found in all samples Three other mutations were seen in 32 of the 33 samples labeled in green including a three amino acid deletion at the spike protein positions 141 to 143 Lastly five synonymous mutations labeled in gray were also detected in all of the cases 8 Mutation profile of Theta Variant Gene Amino acidORF1ab F924FD1554GS2433SL3201PD3681EN3928NL3930FP4715LA5692VS LGV141 143delE484KN501YG593GD614GP681HS875SE1092KH1101YV1176FORF8 K2QN R203KG204RCharacteristic mutations of Theta Variant 9 Gene Amino acidORF1a D1554GS2625FD2980NL3201PD3681EL3930FORF1b P314LL1203FA1291VS LGV141 143delE484KN501YG593GD614GP681HS875SE1092KH1101YV1176FORF8 K2QN R203KG204RHistoryOn February 18 2021 the Department of Health of the Philippines confirmed the detection of two mutations of COVID 19 in Central Visayas after samples from patients were sent to undergo genome sequencing The mutations were later named as E484K and N501Y which were detected in 37 out of 50 samples with both mutations co occurrent in 29 out of these There were no official names for the variants and the full sequence was yet to be identified 1 On March 12 2021 Japan detected the variant on a traveler from the Philippines 2 On March 13 2021 the Department of Health confirmed the mutations constituted a new variant which was designated as lineage P 3 On the same day it also confirmed its first case of lineage P 1 in the country Although the lineages P 1 and P 3 stem from the same lineage B 1 1 28 the department said that the impact of lineage P 3 on vaccine efficacy and transmissibility is yet to be ascertained 10 On March 17 2021 the United Kingdom confirmed its first two cases where Public Health England PHE termed it VUI 21MAR 02 11 On April 30 2021 Malaysia detected 8 cases of lineage P 3 in Sarawak 12 StatisticsConfirmed cases by country as of January 24 2022 Country PANGOLIN 13 outbreak info 9 Regeneron 14 Other sources Philippines 455 513 516 461 15 USA 17 20 17 Germany 11 11 11 Malaysia 10 10 10 13 16 United Kingdom 9 9 9 10 17 Japan 7 8 8 Netherlands 7 7 7 4 18 Canada 5 5 5 Australia 3 3 4 Belgium 3 3 3 China b 3 14 14 Guam 3 3 New Zealand 3 3 3 Norway 3 3 3 Singapore 3 3 3 Angola 2 2 2 South Korea 2 2 2 Sweden 2 2 2 Brazil 1 1 1 Finland 1 1 1 Total 550 620 624 488See also COVID 19 portal Medicine portal Viruses portalCOVID 19 pandemic in the Philippines Variants of SARS CoV 2 Alpha Beta Gamma Delta Epsilon Zeta Eta Iota Kappa Lambda Mu OmicronNotes Other names include VUI 21MAR 02 Lineage B 1 1 28 3 Philippine variant Cases in Hong Kong References a b News CNN Philippines February 18 2021 DOH confirms new COVID 19 mutations in Central Visayas Retrieved May 2 2021 a href Template Cite news html title Template Cite news cite news a last has generic name help a b News Kyodo March 12 2021 New coronavirus variant found in traveler from Philippines Japan Retrieved May 2 2021 a href Template Cite news html title Template Cite news cite news a last has generic name help News Japan Times March 12 2021 Japanese authorities discover a new coronavirus variant in traveler from Philippines Retrieved May 2 2021 a href Template Cite news html title Template Cite news cite news a last has generic name help a b Tracking SARS CoV 2 variants who int World Health Organization a href Template Cite web html title Template Cite web cite web a CS1 maint url status link Variants distribution of cases data gov uk Government Digital Service Tracking SARS CoV 2 variants June 1 2021 Retrieved June 1 2021 Spike Variants Theta variant aka B 1 128 covdb stanford edu Stanford University Coronavirus Antiviral amp Resistance Database 1 July 2021 Retrieved 2021 07 05 Center Philippine Genome PGC SARS CoV 2 Bulletin No 7 Detection and characterization of a new SARS CoV 2 lineage P 3 with spike protein mutations E484K N501Y P681H and LGV 141 143 deletion from samples sequenced through the intensified UP PGC UP NIH and DOH biosurveillance program Philippine Genome Center a b P 3 Lineage Report outbreak info News ABS CBN March 13 2021 DOH confirms new COVID 19 variant first detected in PH first case of Brazil variant Retrieved May 2 2021 a href Template Cite news html title Template Cite news cite news a last has generic name help News Rappler March 17 2021 England reports 2 cases of new COVID 19 variant found in Philippines Retrieved May 2 2021 a href Template Cite news html title Template Cite news cite news a last has generic name help Covid 19 Sarawak detects variant reported in the Philippines April 30 2021 Retrieved April 30 2021 PANGO lineages cov lineages org Regeneron COVID 19 Dashboard covid19dashboard regeneron com Retrieved August 27 2021 Lopez Virgil September 29 2021 DOH detects additional 339 Delta variant cases GMA News Retrieved October 1 2021 Pei Pei Goh July 8 2021 Delta variant detected in Sarawak Retrieved July 13 2021 He said for the Theta variant six cases had been detected in Kuching and seven in Kota Samarahan Variants distribution of case data 13 August 2021 August 13 2021 Retrieved August 13 2021 Variants in the Netherlands rivm nl Retrieved July 16 2021 a href Template Cite web html title Template Cite web cite web a CS1 maint url status link External linksPANGO lineages New Variant Report Report on global distribution of lineage B 1 1 7 GISAID sequencing data base Tracking of COVID 19 variants Retrieved from https en wikipedia org w index php title SARS CoV 2 Theta variant amp oldid 1127278966, wikipedia, wiki, book, books, library,
